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Rui Fernando Marques da Silva. Concluiu o(a) Doutoramento em Farmácia em 2001 pelo(a) Universidade de Lisboa e Doutoramento em n/a em 2001 pelo(a) Universidade de Lisboa Faculdade de Farmácia. É Professor Auxiliar no(a) Universidade de Lisboa Faculdade de Farmácia, Professor Auxiliar no(a) Universidade de Lisboa Faculdade de Farmácia, Investigador no(a) Universidade de Lisboa Instituto de Investigação do Medicamento, Professor Auxiliar no(a) Universidade de Lisboa Faculdade de Farmácia e Professor Auxiliar no(a) Universidade de Lisboa. Publicou 20 artigos em revistas especializadas. Coorientou 1 tese(s) de doutoramento. Recebeu 8 prémio(s) e/ou homenagens. Nas suas atividades profissionais interagiu com 59 colaborador(es) em coautorias de trabalhos científicos.
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Identification

Personal identification

Full name
Rui Fernando Marques da Silva

Citation names

  • Silva, Rui

Author identifiers

Ciência ID
421A-BD8B-09B3
ORCID iD
0000-0002-0118-9357
Google Scholar ID
https://scholar.google.pt/citations?user=tP-jGx4AAAAJ&hl=en
Researcher Id
G-1910-2011
Scopus Author Id
36626089100

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Italian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Slovenian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2001
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Biologia Geral e Celular
Universidade de Lisboa, Portugal
"Estudo das Vias Neurobiológicas de Lesão Cerebral Durante a Hiperbilirrubinémia Neonatal: Comportamento e Vulnerabilidade Celulares" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2010/03/04 - Current Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2001/10/06 - Current Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
1990/12/19 - 2001/11/30 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
1986/10/01 - 1990/12/19 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2002/07 - 2006/06 Membro da Assembleia de Representantes Universidade de Lisboa Faculdade de Farmácia, Portugal
1993/07/22 - 1996/03/14 Membro do Conselho Diretivo Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2022/01 - 2024/12 Análise da desregulação neuroimmune na doença de Alzheimer para uma terapia com miRNAs veiculados por exosomas
Provided by PTCRIS: PTDC/MED-NEU/2382/2021
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2020/01 - 2023/12 Instituto de Investigação do Medicamento
Provided by PTCRIS: UIDP/04138/2020
 Fundação para a Ciência e a Tecnologia, I.P.
2020/01 - 2023/12 Instituto de Investigação do Medicamento
Provided by PTCRIS: UIDB/04138/2020
 Fundação para a Ciência e a Tecnologia, I.P.
2018/08 - 2022/07 TITANIC - CYP46A1 as a new TherapeutIcTAarget in NIemann-Pick type C disease
Provided by PTCRIS: PTDC/MED-NEU/29455/2017
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2017/01 - 2021/06 ONCOLOGIA DE PRECISÃO: TERAPIAS E TECNOLOGIAS INOVADORAS
Provided by PTCRIS: SAICTPAC/0019/2015
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2017/01 - 2021/06 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
722619
 European Commission
2019/01 - 2019/12 Instituto de Investigação do Medicamento
Provided by PTCRIS: UID/DTP/04138/2019
 Fundação para a Ciência e a Tecnologia, I.P.
2015/01 - 2018/12 Instituto de Investigação do Medicamento
Provided by PTCRIS: UID/DTP/04138/2013
 Fundação para a Ciência e a Tecnologia, I.P.
2015 - 2018 Reinforcement of the Framework for Experiential Education in Healthcare in Serbia
03/SAICT/2015
Researcher
European Commission
2015 - 2018 Reinforcement of the Framework for Experiential Education in Healthcare in Serbia
561644-EPP-1-2015-1-RS-EPPKA2-CBHE-JP
 European Commission
2014/02 - 2014/09 LisbonLiving+: Innovative strategies for a healthy life and an active ageing in the Region of Lisbon
Provided by PTCRIS: 135837
135837
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2011/04 Estudo da perturbação da barreira hemato-encefálica por neurotoxinas e modulação por agentes terapêuticos num modelo humano: efeitos da bilirrubina e da endotoxina em células endoteliais de capilares cerebrais e acção protectora de ácidos biliares
Provided by PTCRIS: PTDC/SAU-FCF/68819/2006
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2011/04 Study of the blood-brain barrier disruption by neurotoxins and modulation by therapeutic agents in a human model: effects of bilirubin and endotoxin on brain microvascular endothelial cell monolayer integrity and protective role of bile acids
grant.Provided by PTCRIS: 68819
 Fundação para a Ciência e a Tecnologia, I.P.
2007/08 - 2010/12 Envolvimento da via de sinalização dos estrogéneos e de modificações epigenéticas na regulação da expressão do gene CYP46A1 no encéfalo
Provided by PTCRIS: PTDC/SAU-GMG/64176/2006
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2007/08 - 2010/12 Estrogen signaling and epigenetic modifications in the regulation of the CYP46A1 expression in the brain
64176
Provided by PTCRIS: 64176
 Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2010/12 Acções troficas dos factores neurotróficos: dependência da co-activação de receptores A2A da adenosina
Provided by PTCRIS: PTDC/SAU-NEU/64126/2006
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2010/12 À descoberta de potenciais alterações de neurodesenvolvimento em situações comuns no período neonatal, tais como na hiperbilirrubinemia e na inflamação
Provided by PTCRIS: PTDC/SAU-NEU/64385/2006
grant.Provided by PTCRIS: 64385
Researcher
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2007/07 - 2010/12 Trophic actions of neurotrophic factors: dependency of adenosine A2A receptors co-activation
grant.Provided by PTCRIS: 64126
 Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2009/07 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
Provided by PTCRIS: 82303
82303
grant.Provided by PTCRIS: 55955
Researcher
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
2005/09 - 2008/06 Lesão cerebral pela bilirrubina e impacto nas doenças neurodegenerativas - À procura de sensores, susceptilidades e moduladores
Provided by PTCRIS: POCI/SAU-MMO/55955/2004
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2005/09 - 2008/02 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis.
grant.Provided by PTCRIS: 55919
grant.Provided by PTCRIS: 82707
Researcher
Fundação para a Ciência e a Tecnologia
2005/09 - 2008/02 Mecanismos moleculares envolvidos na regulação da transcrição do gene CYP46 humano - Implicações na homeostasia do colesterol no cérebro.
Provided by PTCRIS: POCI/SAU-MMO/55919/2004
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2022/01/01 - 2024/12/31 Analyzing NeuroIMmune dysregulation in Alzheimer´s disease toward a Therapy with miRNA-loaded Exosomes
PTDC/MED-NEU/2382/2021
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/01 - 2022/07/31 CYP46A1 como um novo alvo terapêutico na Doença de Niemann-Pick de tipo C
PTDC/MED-NEU/29455/2017
Universidade Nova de Lisboa, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2021/06/30 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Instituto Politécnico de Leiria, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2011/04/30 Study of the blood-brain barrier disruption by neurotoxins and modulation by therapeutic agents in a human model: effects of bilirubin and endotoxin on brain microvascular endothelial cell monolayer integrity and protective role of bile acids
PTDC/SAU-FCF/68819/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/08/15 - 2010/12/31 Estrogen signaling and epigenetic modifications in the regulation of the CYP46A1 expression in the brain
PTDC/SAU-GMG/64176/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 Trophic actions of neurotrophic factors: dependency of adenosine A2A receptors co-activation
PTDC/SAU-NEU/64126/2006
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation
PTDC/SAU-NEU/64385/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal

University of Minnesota Twin Cities Department of Neuroscience, United States
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/15 - 2008/06/30 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
POCI/SAU-MMO/55955/2004
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/02/29 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis.
POCI/SAU-MMO/55919/2004
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1992 - 1996 Índices de fragilidade celular à toxicidade pela bilirrubina e seu contributo na prevenção das sequelas resultantes da icterícia neonatal. Investigador responsável: Profª Drª Dora Brites. Projecto PBIC/C/SAU/1570/92 – JNICT. Financiado pela Junta Nacional de Investigação Científica, de 1992 a 1996.
PBIC/C/SAU/1570/92
Researcher
Concluded
1988 - 1993 Bilirrubina. Estudo do mecanismo da sua acção tóxica no recém-nascido. Projecto 1B do Centro de Metabolismos e Genética (Centro SpL3).
Centro SpL3
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
Outputs

Publications

Book
  1. Dietary Polyphenols and Neuroprotection. {MDPI. 2022.
    10.3390/books978-3-0365-2882-3
Book chapter
  1. Silva, Rui; Pogacnik, Lea. "Polyphenols, From Neuroprotection To Safety". In Food Safety Monitoring and Healthy Living, edited by BADEA, Mihaela ; FLOROIAN, Laura ; Gaman, Laura. Brasov, Romania: Transilvania University Press, Brasov, Romania, 2019.
  2. Silva, Rui; Pogacnik, Lea. "Food natural products for neuroprotection". In Food safety and healthy living, edited by BADEA, Mihaela ; FLOROIAN, Laura, 30-36. Brasov: Editura Universitath Transilvanîa din Brasov, 2018.
    Published
  3. Palmela, I.; Correia,L.; Silva, Rui; Sasaki, H.; Kim, K.S.; Brites, D.; Brito, M.A.. "Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study.". In Ontogeny and Phylogeny of Brain Barrier Mechanisms, edited by Saunders, N.R.; Stolp, H.B.; Liddelow, S.A ., 335-345. Frontiers Research Topics, 2016.
    Published
  4. Brites, D.; Fernandes, A.; Falcão, A.S.; Brito, M.A.; Silva, Rui. "Neuronal and Glial Reactivity to Unconjugated Bilirubin: Dissecting the Molecular Mechanisms.". In Encyclopedic Reference of Neuroscience. Neuroimmunology., 1726-1730. Heidelberg, Germany: Springer, 2009.
    Published
  5. Brito, M.A.; Rosa, A.I.; Silva, Rui; Falcão, A.S.; Fernandes, A.; Brites, D.. "Oxidative stress and disruption of the nervous cell.". In Focus on Brain Research, edited by Resch, C.J., 1-33. NY, United States: Nova Science Publishers, 2007.
    Published
  6. Brito, M.A.; Silva, Rui; Brites, D.. "Cell response to hyperbilirubinemia: a journey along key molecular events". In New Trends in Brain Research, edited by Chen. F.J ., 1-38. NY: Nova Science Publishers, Inc, 2006.
    Published
  7. Silva, Rui; Brito, M.A.; Falcão, A.S.; Fernandes, A.; Gordo, C.; Brites, D.. "Nerve cell cultures as models for assessment of pollutant cytotoxicity". In Bulletin of the Transilvania University of Brasov, Series D, edited by Badea, M.; Coman, G.H.; Dima, L., 160-167. Brasov, Romania: Transilvania University Press, Brasov, Romania, 2005.
    Published
Journal article
  1. Rui F. M. Silva; Lea Pogacnik. "Neuroprotective Properties of Food-Borne Polyphenols in Neurodegenerative Diseases". Antioxidants 10 11 (2021): 1810-1810. https://doi.org/10.3390/antiox10111810.
    10.3390/antiox10111810
  2. "Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects". Pediatric Medicine 0 (2021): 0-0. http://dx.doi.org/10.21037/pm-21-37.
    10.21037/pm-21-37
  3. RFM Silva; Lea Pogacnik. "Polyphenols from Food and Natural Products: Neuroprotection and Safety". Antioxidants (2020): https://www.mdpi.com/2076-3921/9/1/61.
    10.3390/antiox9010061
  4. Lea POGACNIK; Rui F.M. SILVA. "Polifenoli – med zašcito nevronov in potencialno toksicnostjo". Acta Agriculturae Slovenica (2020): https://publons.com/publon/41321892/.
    10.14720/AAS.2020.115.2.1472
  5. Silva, R.F.M.; Pogacnik, L.. "Food, polyphenols and neuroprotection". Neural Regeneration Research 12 4 (2017): 582-583. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019063607&partnerID=MN8TOARS.
    10.4103/1673-5374.205096
  6. Garcia, G.; Nanni, S.; Figueira, I.; Ivanov, I.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; et al. "Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation". Food Chemistry 215 (2017): 274-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-84980320139&partnerID=MN8TOARS.
    10.1016/j.foodchem.2016.07.128
  7. Gama-Marques, J.; Tinoco, I.; Pedro, I.; Leote, F.; Ouakinin, R.S.S.. "Unconjugated bilirubin and acute schizophrenia: A probable correlation? | Bilirrubina no conjugada y esquizofrenia aguda: ¿una correlación probable?". Actas Espanolas de Psiquiatria 45 2 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016953363&partnerID=MN8TOARS.
  8. Gama-Marques, Joao; Tinoco, Isabel; Pedro, Isaias; Leote, Filipe; Silva, Rui; Ouakinin, Slvia. "Unconjugated bilirubin and acute schizophrenia: a probable correlation?". Actas Espanolas de Psiquiatria (2017): https://publons.com/publon/7478782/.
  9. Pogacnik, L.; Pirc, K.; Palmela, I.; Skrt, M.; Kwang, K.S.; Brites, D.; Brito, M.A.; Ulrih, N.P.; Silva, R.F.M.. "Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro". Brain Research 1651 (2016): 17-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990903127&partnerID=MN8TOARS.
    10.1016/j.brainres.2016.09.020
  10. Ribeiro, F.F.; Neves-Tomé, R.; Assaife-Lopes, N.; Santos, T.E.; Silva, R.F.M.; Brites, D.; Ribeiro, J.A.; Sousa, M.M.; Sebastião, A.M.. "Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons". Brain Structure and Function (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930903335&partnerID=MN8TOARS.
    10.1007/s00429-015-1072-1
  11. Palmela, I.; Correia, L.; Silva, R.F.M.; Sasaki, H.; Kim, K.S.; Brites, D.; Brito, M.A.. "Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: An in vitro study". Frontiers in Neuroscience 9 FEB (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924347868&partnerID=MN8TOARS.
    10.3389/fnins.2015.00080
  12. "REMOVED: Axon elongation is regulated by adenosine A 2A receptors". International Journal of Developmental Neuroscience (2015): https://publons.com/publon/7478786/.
    10.1016/J.IJDEVNEU.2015.04.229
  13. Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Gomes, C.; Fernandes, A.; Barateiro, A.; Tiribelli, C.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Adverse secondary impacts". Neurotoxicity Research 26 1 (2014): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903741375&partnerID=MN8TOARS.
    10.1007/s12640-013-9427-y
  14. Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Early beneficial effects". Neurochemical Research 38 3 (2013): 644-659. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876416140&partnerID=MN8TOARS.
    10.1007/s11064-012-0963-2
  15. Falcao, A. S.; Vaz, A. R.; Silva, S. L.; Barateiro, A.; Fernandes, A.; Silva, R. F.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin". Journal of Neurochemistry (2013): https://publons.com/publon/6440816/.
  16. Ribeiro, F. F.; Silva, R.; Fernandes, A.; Brites, D.; Ribeiro, J. A.; Sebasti, A. M.. "Adenosine A2A receptor: the mechanism behind axonal elongation in primary cortical cultures". Journal of Neurochemistry (2013): https://publons.com/publon/11733622/.
  17. Silva, S.L.; Vaz, A.R.; Diógenes, M.J.; Van Rooijen, N.; Sebastião, A.M.; Fernandes, A.; Silva, R.F.M.; et al. "Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10". Neuropharmacology 62 7 (2012): 2397-2407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859103402&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2012.02.002
  18. Palmela, I.; Cardoso, F.L.; Bernas, M.; Correia, L.; Vaz, A.R.; Silva, R.F.M.; Fernandes, A.; et al. "Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity". Current Neurovascular Research 8 2 (2011): 153-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955733304&partnerID=MN8TOARS.
    10.2174/156720211795495358
  19. Silva, S.L.; Osório, C.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Silva, R.F.M.; Brites, D.. "Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin". Journal of Neurochemistry 117 3 (2011): 412-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954420884&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07200.x
  20. Fernandes, A.; Barateiro, A.; Falcão, A.S.; Silva, S.L.-A.; Vaz, A.R.; Brito, M.A.; Marques Silva, R.F.; Brites, D.. "Astrocyte reactivity to unconjugated bilirubin requires TNF-a and IL-1ß receptor signaling pathways". GLIA 59 1 (2011): 14-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349235777&partnerID=MN8TOARS.
    10.1002/glia.21072
  21. Brites, D.; Silva, S. L.; Oliveira, A.; Vaz, A. R.; Diogenes, M. J.; van Rooijen, N.; Sebastiao, A. M.; et al. "MICROGLIA FACES FEATURING A POTENTIAL PATHOLOGICAL NEURAL/GLIAL BEHAVIOR HIGHLY COMMON IN NEONATAL LIFE". Glia (2011): https://publons.com/publon/6440797/.
  22. Silva, S.L.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation". Neurobiology of Disease 40 3 (2010): 663-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957807564&partnerID=MN8TOARS.
    10.1016/j.nbd.2010.08.010
  23. Brito, M.A.; Vaz, A.R.; Silva, S.L.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "N-methyl-D-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity". Molecular Medicine 16 9-10 (2010): 372-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956632156&partnerID=MN8TOARS.
    10.2119/molmed.2009.00152
  24. "Adenosine A2A and BDNF TrkB receptors have independent roles upon neuronal maturation". Purinergic Signalling (2010): https://publons.com/publon/7478794/.
  25. Vaz, A. R.; Silva, S. L.; Falcao, A. S.; Barateiro, A.; Fernandes, A.; Brito, M. A.; Silva, R.; Brites, D.. "BILIRUBIN IN THE BRAIN: NEUROTOXIC EFFECTS, THERAPEUTIC PROMISES AND REGIONAL VULNERABILITY". Pediatric Research (2010): https://publons.com/publon/6440754/.
    10.1203/00006450-201011001-00246
  26. Brites, D.; Fernandes, A.; Falcão, A.S.; Gordo, A.C.; Silva, R.F.M.; Brito, M.A.. "Biological risks for neurological abnormalities associated with hyperbilirubinemia". Journal of Perinatology 29 SUPPL. (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-59549101479&partnerID=MN8TOARS.
    10.1038/jp.2008.214
  27. Vaz, A. R.; Silva, Leitao S.; Barateiro, A.; Falcao, A. S.; Fernandes, A.; Silva, R. F. M.; Brito, M. A.; Brites, D.. "NITRIC OXIDE MEDIATES INFLAMMATION-INDUCED APOPTOTIC FEATURES AND NEURONAL DYSFUNCTION AT AN EARLY STAGE OF NEURODEVELOPMENT". Glia (2009): https://publons.com/publon/6440751/.
  28. Vaz, A. R.; Silva, S. Leitao; Barateiro, A.; Fernandes, A.; Falcao, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.. "Inhibition of nitric oxide production prevents apoptotic features mediated by inflammation in immature neurons". Free Radical Research (2009): https://publons.com/publon/7478756/.
  29. Falcao, A.; Fernandes, A.; Silva, S. L.; Vaz, A. R.; Brito, M. A.; Henrique, D.; Silva, R. F.; Brites, D.. "ALTERATIONS IN NEURODEVELOPMENT OCCUR BY MODERATED LEVELS OF UNCONJUGATED BILIRUBIN AND INCREASE WHEN NEURONS ARE CO-CULTURED WITH ASTROCYTES". Acta Paediatrica (2009): https://publons.com/publon/6440812/.
  30. Correia, M.; Cardoso, F. L.; Sousa, D.; Pamela, I.; Vaz, A. R.; Silva, S. L.; Falcao, A. S.; et al. "PREVENTIVE EFFECTS OF BILE ACIDS ON BILIRUBIN-INDUCED APOPTOSIS OF HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELLS". Haematologica (2009): https://publons.com/publon/6440759/.
  31. Silva, Leitao S.; Osorio, C.; Vaz, A. R.; Barateiro, A.; Falcao, A. S.; Brito, M. A.; Fernandes, A.; Silva, R. F. M.; Brites, D.. "MICROGLIA ACQUIRES A PRAGOCYTIC OR PRO-INFLAMMATORY PHENOTYPE WHEN BILIRUBIN GETS INTO THE BRAIN". Glia (2009): https://publons.com/publon/6440752/.
  32. Falcao, A.; Torrado, E.; Fernandes, A.; Abranches, E.; Bekman, E.; Brito, A.; Silva, R. F. M.; Henrique, D.; Brites, D.. "EXPLORING MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP1) EXPRESSION DURING NEURAL STEM CELL PROLIFERATION AND DIFERENTIATION, NERVE CELL MATURATION AND NEURO-GLIA INTERACTIONS". Glia (2009): https://publons.com/publon/4708396/.
  33. Brito, M.A.; Lima, S.; Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid". NeuroToxicology 29 2 (2008): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749156518&partnerID=MN8TOARS.
    10.1016/j.neuro.2007.11.002
  34. Brito, M.A.; Rosa, A.I.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells". Neurobiology of Disease 29 1 (2008): 30-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549090063&partnerID=MN8TOARS.
    10.1016/j.nbd.2007.07.023
  35. Milagre, I.; Nunes, M.J.; Gama, M.J.; Silva, R.F.; Pascussi, J.M.; Lechner, M.C.; Rodrigues, E.. "Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors". Journal of Neurochemistry 106 2 (2008): 835-849. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649087490&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05442.x
  36. Falcão, A.S.; Silva, R.F.M.; Pancadas, S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus". Journal of Neuroscience Research 85 6 (2007): 1229-1239. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248141645&partnerID=MN8TOARS.
    10.1002/jnr.21227
  37. Falcão, A.S.; Bellarosa, C.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Tiribelli, C.; Brites, D.. "Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin". Neuroscience 144 3 (2007): 878-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845899686&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.10.026
  38. Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes". European Journal of Neuroscience 25 4 (2007): 1058-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847203682&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2007.05340.x
  39. Fernandes, A.; Vaz, A.R.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin". Journal of Neuropathology and Experimental Neurology 66 9 (2007): 789-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548454884&partnerID=MN8TOARS.
    10.1097/nen.0b013e3181461c74
  40. Falcão, A.S.; Silva, R.F.M.; Fernandes, A.; Brito, M.A.; Brites, D.. "Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes". Brain Research 1149 1 (2007): 191-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247503256&partnerID=MN8TOARS.
    10.1016/j.brainres.2007.02.039
  41. Barros, D.O.; Xavier, S.M.L.; Barbosa, C.O.; Silva, R.F.; Freitas, R.L.M.; Maia, F.D.; Oliveira, A.A.; Freitas, R.M.; Takahashi, R.N.. "Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats". Neuroscience Letters 416 3 (2007): 227-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047107690&partnerID=MN8TOARS.
    10.1016/j.neulet.2007.01.057
  42. Falcaeo, Ana S.; Silva, Sandra L.; Fernandes, Adelaide; Vaz, Ana R.; Silva, Rui F. M.; Brito, Maria A.; Brites, Dora. "Astrocytes modulate neuronal injury during hyperbilirubinemia". Neuron Glia Biology (2007): https://publons.com/publon/6440803/.
  43. Brito, Maria A.; Vaz, Ana R.; Lima, Silvia; Fernandes, Adelaide; Falcao, Ana S.; Silva, Sandra L.; Silva, Rui F. M.; Brites, Dora. "Bilirubin induces oxidative stress in neurons, which is prevented by nNOS inhibition". Free Radical Research (2007): https://publons.com/publon/7478749/.
  44. Brito, Maria Alexandra; Lima, Silvia; Fernandes, Adelaide; Fulcao, Ana Sofia; Silva, Rui F. M.; Butteifield, D. Allan; Brites, Dora. "Roles of amyloid beta-peptide-associated oxidative stress and proteomics-identified brain protein oxidative modifications in the pathogenesis of Alzheimer's disease". Free Radical Biology and Medicine (2007): https://publons.com/publon/6440763/.
  45. Silva, Sandra L.; Vaz, Ana Rita; Fernandes, Adelaide; Falco, Ana S.; Brito, M. Alexandra; Silva, Rui F. M.; Brites, Dora. "Profile of early microglial activation by unconjugated bilirubin". Neuron Glia Biology (2007): https://publons.com/publon/6440820/.
  46. Vaz, Ana Rita; Silva, Sandra L.; Fernandes, Adelaide; Falcao, Ana Sofia; Silva, Rui F. M.; Brito, M. Alexandra; Brites, Dora. "Cellular mechanisms underlying dysfunction of immature neurons by hyperbilirubinemia and inflammation". Neuron Glia Biology (2007): https://publons.com/publon/6440809/.
  47. Alexandra Brito, M.; Silva, R.F.M.; Brites, D.. "Bilirubin toxicity to human erythrocytes: A review". Clinica Chimica Acta 374 1-2 (2006): 46-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749989103&partnerID=MN8TOARS.
    10.1016/j.cca.2006.06.012
  48. Gordo, A.C.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Unconjugated bilirubin activates and damages microglia". Journal of Neuroscience Research 84 1 (2006): 194-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745770001&partnerID=MN8TOARS.
    10.1002/jnr.20857
  49. Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state". Acta Neuropathologica 112 1 (2006): 95-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745401404&partnerID=MN8TOARS.
    10.1007/s00401-006-0078-4
  50. Silva, R.F.M.; Falcão, A.S.; Fernandes, A.; Gordo, A.C.; Brito, M.A.; Brites, D.. "Dissociated primary nerve cell cultures as models for assessment of neurotoxicity". Toxicology Letters 163 1 (2006): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644832098&partnerID=MN8TOARS.
    10.1016/j.toxlet.2005.09.033
  51. Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Gordo, A.C.; Gama, M.J.; Brito, M.A.; Brites, D.. "Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin". Journal of Neurochemistry 96 6 (2006): 1667-1679. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644812051&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.03680.x
  52. Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells". Neurobiology of Disease 20 2 (2005): 199-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-26944464585&partnerID=MN8TOARS.
    10.1016/j.nbd.2005.03.001
  53. Brito, MA; Rosa, AI; Fernandes, A; Falcao, AS; Silva, RFM; Brites, D. "Hyperbilirubinemia induces oxidative stress in rat brain primary neuronal cultures". Free Radical Research (2005): https://publons.com/publon/6440795/.
  54. Falcao, AS; Bellarosa, C; Fernandes, A; Brito, MA; Silva, RFM; Tiribelli, C; Brites, D. "Putative role of a decreased MRP1 expression in immature astrocytes in the susceptibility to biurubin-induced toxicity". Journal of Hepatology (2005): https://publons.com/publon/6440802/.
  55. Fernandes, A.; Silva, R.F.M.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS". Journal of Neuroimmunology 153 1-2 (2004): 64-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242679583&partnerID=MN8TOARS.
    10.1016/j.jneuroim.2004.04.007
  56. Fernandes, A; Falcao, AS; Silva, RF; Brito, MA; Brites, D. "Role of TNF-alpha and biological modifiers on cytokine production after astrocyte exposure to bilirubin: Relationship to NF-kappa B". Pediatric Research (2004): https://publons.com/publon/6440822/.
  57. Falcao, AS; Fernandes, A; Brito, MA; Silva, RF; Brites, D. "Bilirubin-induced release of cytokines and glutamate depends from neural cell type and decreases with differentiation". Pediatric Research (2004): https://publons.com/publon/6440821/.
  58. Fernandes, A; Falcao, AS; Silva, RFM; Brito, MA; Brites, D. "Interleukin-10 modulates the immune stimulant effect of bilirubin in ratastroglial cells". Glia (2003): https://publons.com/publon/6440827/.
  59. Falcao, AS; Fernandes, A; Brito, MA; Silva, RF; Brites, D. "Are interleukins new players in the pathophysiology of bilirubin encephalopathy?". Pediatric Research (2003): https://publons.com/publon/6440825/.
  60. "Bilirubin-induced senescence is exacerbated in human neonatal red blood cells". Pediatric Research (2003): https://publons.com/publon/7478757/.
  61. Fernandes, A; Falcao, AS; Silva, RF; Brito, MA; Brites, D. "Ability of glycoursodeoxycholate to prevent astrocyte injury by bilirubin may be restricted to the membrane pathway-dependent cytotoxicity". Journal of Hepatology (2003): https://publons.com/publon/6440826/.
    10.1016/S0168-8278(03)80017-X
  62. "Neonatal jaundice: A(TA)7TAA polymorphism, breast milk bglucuronidase". Pediatric Research (2003): https://publons.com/publon/7478766/.
  63. Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes". Cell Biology and Toxicology 18 3 (2002): 181-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035986194&partnerID=MN8TOARS.
    10.1023/A:1015563704551
  64. Silva, R.F.M.; Rodrigues, C.M.P.; Brites, D.. "Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin". Pediatric Research 51 4 I (2002): 535-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036202904&partnerID=MN8TOARS.
    10.1203/00006450-200204000-00022
  65. Rodrigues, C.M.P.; Solá, S.; Silva, R.F.M.; Brites, D.. "Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin". Pediatric Research 51 1 (2002): 112-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036134456&partnerID=MN8TOARS.
    10.1203/00006450-200201000-00020
  66. Silva, RF; Brito, MA; Fernandes, A; Correia, LE; Brites, D. "Bilirubin-induced TNF-alpha release and apoptosis in astrocytes is enhanced by endotoxin, even at clinically relevant concentrations". Hepatology (2002): https://publons.com/publon/6440824/.
  67. Silva, RFM; Rodrigues, CMP; Brites, D. "Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin". Pediatric Research (2002): https://publons.com/publon/7478760/.
    10.1203/00006450-200204000-00022
  68. Rodrigues, CMP; Sola, S; Silva, RFM; Brites, D. "Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin". Pediatric Research (2002): https://publons.com/publon/7478755/.
    10.1203/00006450-200201000-00020
  69. Silva, R.F.M.; Mata, L.M.; Gulbenkian, S.; Brites, D.. "Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin". Neurochemical Research 26 7 (2001): 793-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034857845&partnerID=MN8TOARS.
    10.1023/A:1011608017870
  70. Silva, R.F.M.; Rodrigues, C.M.P.; Brites, D.. "Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid". Journal of Hepatology 34 3 (2001): 402-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035072101&partnerID=MN8TOARS.
    10.1016/S0168-8278(01)00015-0
  71. "Comparative study of adverse effects of hyperbilirubinaemia on foetal and adult erythrocytes. Influence of acidosis". Journal of Hepatology (2001): https://publons.com/publon/7478792/.
    10.1016/S0168-8278(01)81540-3
  72. Brito, M.A.; Silva, R.; Tiribelli, C.; Brites, D.; Brito, MA; Silva, R; Tiribelli, C; Brites, D. "Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management". European Journal of Clinical Investigation 30 3 (2000): 239-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034015283&partnerID=MN8TOARS.
    10.1046/j.1365-2362.2000.00612.x
  73. Rodrigues, CMP; Sola, S; Silva, R; Diogenes, MJ; Brites, D. "Apoptosis induced by deoxycholic acid unconjugated bilirubin and amyloid beta-peptide reflects mitochondrial perturbation which may be inhibited by ursodeoxycholic acid". Journal of Hepatology (2000): https://publons.com/publon/7478774/.
    10.1016/S0168-8278(00)80482-1
  74. Rodrigues, CMP; Sola, S; Silva, R; Brites, D; Rodrigues, C.M.; Solá, S.; Silva, R.; Brites, D.. "Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization". Molecular Medicine 6 11 (2000): 936-946. https://publons.com/publon/7478790/.
    10.1007/BF03401828
  75. "Additive effect of chenodeoxycholic acid on toxicity of unconjugated bilirubin to brain cells". Journal of Hepatology (2000): https://publons.com/publon/7478773/.
    10.1016/S0168-8278(00)80664-9
  76. Silva, R.; Mata, L.R.; Gulbenkian, S.; Brito, M.A.; Tiribelli, C.; Brites, D.. "Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: Role of concentration and pH". Biochemical and Biophysical Research Communications 265 1 (1999): 67-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033547349&partnerID=MN8TOARS.
    10.1006/bbrc.1999.1646
  77. Brites, D.; Rodrigues, C.M.P.; Van-Zeller, H.; Alexandra Brito; Silva, R.. "Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal". European Journal of Obstetrics Gynecology and Reproductive Biology 80 1 (1998): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032458943&partnerID=MN8TOARS.
    10.1016/S0301-2115(98)00086-4
  78. "Bilirubin-induced apoptosis in astrocytes is prevented by ursodeoxycholic acid.". Hepatology (1998): https://publons.com/publon/7478778/.
  79. Brites, D.; Silva, R.; Brito, A.; Brites, D; Silva, R; Brito, A. "Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age". Scandinavian Journal of Clinical and Laboratory Investigation 57 4 (1997): 337-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030739034&partnerID=MN8TOARS.
    10.3109/00365519709099407
  80. Maria A. Brito; Rui M. Silva; Deolinda C. Matos; António T. da Silva; Dora T. Brites. "Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia". Clinica Chimica Acta 249 1-2 (1996): 149-165. http://dx.doi.org/10.1016/0009-8981(96)06285-7.
    10.1016/0009-8981(96)06285-7
  81. Brites, D.; Brito, M.A.; Silva, Rui. "Icterícia neonatal e toxicidade da bilirrubina. Novos aspectos.". Revista Portuguesa de Pediatria 24 (1993): 325-330.
    Published
  82. Marques, J.G.; Silva, Rui; Brites, D.; Esaguy, A.. "Síndroma de Gilbert - caso clínico.". Revista Portuguesa de Pediatria 23 5 (1992): 313-319.
    Published
  83. Carvalhosa, G; Berdeja, AM; Borjes, D; Santos, S; Silva, Rui; Brites, D.; Estrada, A. "Icterícia e estenose hipertrófica do piloro - qual a causa?". Revista Portuguesa de Pediatria 21 (1990): 167-172.
    Published
  84. Silva, Rui; Brites, D.; Correia, L.E.. "Interacção da bilirrubina com a membrana eritrocitária. Resultados preliminares.". Arquivos Portugueses das Ciências Biológicas 23 1 (1989): 99-109.
    Published
  85. Brites, D.; Silva, Rui. "Doseamento enzimático dos ácidos biliares. Optimização da reacção.". Revista Portuguesa de Farmácia 36 3, 4 (1985): 8-15.
    Published
Thesis / Dissertation
  1. Pereira, Maria Beatriz de Castela Batista Dias. "Role of astrocytes in neurodegeneration". Master, 2021. http://hdl.handle.net/10451/53108.
  2. Branco, Joana Ferreira. "O papel das células de glia nas doenças neurodegenerativas". Master, 2020. http://hdl.handle.net/10451/52412.
  3. Nogueira, João Filipe Andrade. "Possibilidades terapêuticas dos polifenóis alimentares na doença de Alzheimer". Master, 2020. http://hdl.handle.net/10451/52653.
  4. Pedrosa, Inês Duarte Ferreira. "Biological activity of naphthoquinones: Cytotoxic activity against eukaryotic plant cells and against eukaryotic human cells. Antimicrobial activity of naphthoquinones against selected microorganisms". Master, 2017. http://hdl.handle.net/10451/36024.
  5. Machado, Catarina Ferreira de Lemos. "A excitotoxicidade nas doenças neurodegenerativas". Master, 2016. http://hdl.handle.net/10451/34609.
  6. Teixeira, Ana Maria Completo da Silva. "Mecanismos de neuroproteção pelos polifenóis naturais presentes na alimentação". Master, 2015. http://hdl.handle.net/10451/27114.
  7. Silva, Sandra Isabel Leitão da, 1984-. "Molecular mechanisms of microglia reactivity to bilirubin : evaluation of potential neurological effects". PhD, 2010. http://hdl.handle.net/10451/2477.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
1988/04/12 Ácidos biliares. Importância da sua determinação. Reunião Clínica do Hospital Pediátrico de Coimbra
Hospital Pediátrico de Coimbra (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2006 - 2006 New Findings on Neuropathological Effects of Hyperbilirubinemia in Astrocytes and Neurons - Evaluation of Cell Susceptibilities and of Neuritic Development
Co-supervisor
 Farmácia (PhD)
Universidade de Lisboa, Portugal
Distinctions

Award

2020 THE MOST INTERESTING TOPIC
Universitatea Transilvania din Brasov, Romania
2020 THE MOST APPRECIATED PROFESSOR
Universitatea Transilvania din Brasov, Romania

Other distinction

2012 Best Poster
2004 Best poster presentation
2002 Programa Gulbenkian de Estímulo à Investigação
Fundação Calouste Gulbenkian, Portugal
2001 Best presentation on liver
2001 Research award
Ministério da Saúde, Mozambique
2000 Best oral presentation by young researchers
1999 Best poster presentation
1999 Best poster presentation