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Trypanosoma brucei (T. brucei) is a protozoan unicellular parasite that causes lethal diseases in sub-Saharan Africa: sleeping sickness in humans and nagana in cattle. The veterinary disease has a devastating impact on socioeconomic development and animal welfare in Africa and South America. To maintain a chronic infection, T. brucei employs a variety of sophisticated mechanisms that allow parasites to escape the host immune system and to be best adapted to the host environment (1). My laboratory has used molecular, genetic and cellular approaches to study some of these mechanisms, including tissue tropism (2-6), circadian rhythm (7, 8) and gene regulation (9,10). In the last 5 years, my laboratory has been exclusively funded by competitive grants. In particular from Howard Hughes Medical Institute (International program, 2012-2018, 750kUSD), European Research Council (consolidator grant, 2018-2022, 2M¿) and La Caixa Foundation (2021-2023, 500k¿). I also participate in two network grants from Wellcome Trust Collaborative program (Cobalt, 2018-2021) and International Training Network PhD program (Cell2cell, 2020-2024). 1. Silva Pereira, S., Trindade, S., De Niz, M., and Figueiredo, L.M. (2019). Tissue tropism in parasitic diseases. Open Biol 9, 190036. 2. Trindade, S., Rijo-Ferreira, F., Carvalho, T., Pinto-Neves, D., Guegan, F., Aresta-Branco, F., Bento, F., Young, S.A., Pinto, A., Van Den Abbeele, J., et al. (2016). Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice. Cell Host Microbe 19, 837¿848. 3. Carvalho, T., Trindade, S., Pimenta, S., Santos, A.B., Rijo-Ferreira, F., and Figueiredo, L.M. (2018). Trypanosoma brucei triggers a marked immune response in male reproductive organs. PLoS Negl Trop Dis 12, e0006690. 4. De Niz, M., Brás, D., Ouarné, M., Pedro, M., Nascimento, A. M., Henao Misikova, L., Franco, C. A., and Figueiredo, L. M. (2021). Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence. Cell Rep 36, 109741. 5. Machado, H., Bizarra-Rebelo, T., Costa-Sequeira, M., Trindade, S., Carvalho, T., Rijo-Ferreira, F., Rentroia-Pacheco, B., Serre, K., and Figueiredo, L. M. (2021). Trypanosoma brucei triggers a broad immune response in the adipose tissue. PLoS Pathog 17, e1009933. 6. Trindade, S., De Niz, M., and Figueiredo, L. M. (2021). Persistence behavior in African trypanosomes during adipose tissue colonization. Research Square (under review) 7. Rijo-Ferreira, F., Pinto-Neves, D., Barbosa-Morais, N.L., Takahashi, J.S., and Figueiredo, L.M. (2017). Trypanosoma brucei metabolism is under circadian control. Nat Microbiol 2, 17032. 8. Rijo-Ferreira, F., Carvalho, T., Afonso, C., Sanches-Vaz, M., Costa, R.M., Figueiredo, L.M., and Takahashi, J.S. (2018). Sleeping sickness is a circadian disorder. Nat Commun 9, 62. 9. Aresta-Branco, F., Sanches-Vaz, M., Bento, F., Rodrigues, J.A., and Figueiredo, L.M. (2019). African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system. Proc. Natl. Acad. Sci. 116, 20725¿20735. 10. Guegan, F., Bento, F., Neves, D., Sequeira, M., Notredame, C., and Figueiredo, L. M. (2020). A long non-coding RNA controls parasite differentiation in African trypanosomes. bioRxiv 11. Viegas, I. J., Pereira de Macedo, J., De Niz, M., Rodrigues, J. A., Aresta-Branco, F., Jaffrey, S. R., and Figueiredo, L. M. (2020). N6-methyladenosine in poly(A) tails stabilize VSG transcripts. Nature (in press)
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Identification

Personal identification

Full name
Luisa M Figueiredo

Citation names

  • Figueiredo, Luisa M.

Author identifiers

Ciência ID
421C-420D-E7BD
ORCID iD
0000-0002-5752-6586
Education
Degree Classification
2002/07/11
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Outra:Parasitologia Molecular
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Chromosome Ends in Plasmodium Falciparum: Dynamics of Telomeres, Roles of Subtelomeres and Investigation of Telomerase as An Antimalarial Drug Target" (THESIS/DISSERTATION)
1993/09/20 - 1997/09/10
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Molecular characterisation of a Drosophila 3'-end mRNA forming complex" (THESIS/DISSERTATION)
 18
Affiliation

Science

Category
Host institution 		Employer
2009/12/01 - Current Coordinating Researcher (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2008/01/04 - 2009/11/30 Contracted Researcher (Research) Rockefeller University, United States
2003/01/04 - 2008/01/03 Postdoc (Research) Rockefeller University, United States

Teaching in Higher Education

Category
Host institution 		Employer
2021/12/01 - Current Invited Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2021/01/01 - 2025/02/28 Mechanism and function of epitranscriptomic poly(A) tail modifications in African trypanosomes (TrypM6A).
LA CAIXA - TRYPM6A - HR20-00361 - LFIGUEIREDO
Principal investigator
Instituto de Medicina Molecular, Portugal
 Caixabank SA
Ongoing
2018/08/01 - 2024/07/31 Exploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease
FatTryp
Principal investigator
Instituto de Medicina Molecular, Portugal
 European Research Council
Ongoing
2019/11/01 - 2024/01/31 What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation
info:eu-repo/grantAgreement/EC/H2020/860675/EU
Member
Instituto de Medicina Molecular, Portugal

Schweizerisches Tropen- und Public Health-Institut, Switzerland

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Germany

Ludwig-Maximilians-Universitat Munchen, Germany

Institut Curie, France

Karolinska Institutet, Sweden

Weizmann Institute of Science, Israel

University of Oxford, United Kingdom

Radboud Universiteit, Netherlands
European Commission
Ongoing
2022/07/15 - 2023/12/14 Poly(A) methylation as novel tool for mRNA-therapeutics
LA/50005/2020
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2018/06/01 - 2021/05/31 The Importance of Extra-Vascular Parasite Reservoirs in Mice and Cattle
FatReservoir -LISBOA-01-0145-FEDER-029161
Other
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/02/01 - 2021/01/31 COBALT - Challenging trypanosome antigenic variation paradigms using natural systems
UNS39799
UNS39799
Other
Instituto de Medicina Molecular, Portugal

The University of Edinburgh, United Kingdom
Wellcome Trust
Ongoing
2017/01/01 - 2020/12/31 ONEIDA - An Omics Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance
SAICTPAC/0015/2015
Other
Instituto de Medicina Molecular, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2020/12/31 An OMICS Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance (ONEIDA)
SAICTPAC/0015/2015
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Concluded
2016/07/01 - 2019/12/31 Metabolic consequences of an infection by African trypanosomes
PTDC/BIM-MET/4471/2014
PTDC/BIM-MET/4471/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/01/01 - 2018/12/31 Long non-coding RNAs as new diagnostic biomarkers for African sleeping sickness
PTDC/DTPEPI/7099/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/02/01 - 2017/01/31 How parasites use epigenetics to evade host defenses
Project No. 55007419
Principal investigator
Instituto de Medicina Molecular, Portugal
 Howard Hughes Medical Institute
Concluded
2011/01/01 - 2016/12/31 The role of chromatin in antigenic variation of African Trypanosomes
Project No. 2151
Principal investigator
Instituto de Medicina Molecular, Portugal
 Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
Concluded
2011/03 - 2014/08 Screening of chromatin factors involved in antigenic variation in Trypanosoma brucei
113225
Provided by PTCRIS: 113225
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2011/02 - 2014/07 The role of histone H1 in antigenic variation of African trypanosomes
115864
Provided by PTCRIS: 115864
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/04/01 - 2014/03/31 Chromatin and antigenic variation: The role of histone H1 in gene regulation in African trypanosomes
info:eu-repo/grantAgreement/EC/FP7/256299/EU
Principal investigator
Instituto de Medicina Molecular, Portugal
 European Commission
Concluded
2009/12/01 - 2012/11/30 Epigenetics of antigenic variation: defining new drug targets that make African trypanosomes more susceptible to the host immune response
P-105333
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação Calouste Gulbenkian
Concluded
1998/08/01 - 2002/07/31 CHARACTERISATION OF THE TELOMERASE OF MALARIA PARASITES: ROLE IN CELL SURVIVAL AND DEVELOPMENT OF SPECIFIC INHIBITORS
PRAXIS XXI/BD/16020/98
Institut Pasteur, France
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute of Molecular Medicine João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2021/05/31 Importância dos Reservatórios de Parasitas Extravasculares em Gado e Modelos Laboratoriais de Ratinhos
PTDC/CVT-CVT/29161/2017
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/01/01 - 2019/12/31 Molecular Basis For The Efficient Biology Of Trypanosome Parasitism
IF/01050/2014/CP1236/CT0008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/04/30 Uma aproximação de Biologia de Sistemas para o estudo dos factores essenciais para a N-glicosilação complexa em Trypanosoma brucei
PTDC/BBB-BSS/0827/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/02/17 Projecto Estratégico - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Luisa M. Figueiredo; David Horn. "Epigenetic Regulation in T. brucei: Changing Coats Is a Chance to Survive.". In Epigenetics of Infectious Diseases, 221-241. Springer, 2017.
    10.1007/978-3-642-41566-1_7
Conference poster
  1. Serra, Lúcia; Manav MC; Idalio J. Viegas; Macedo JP; Passmore LA; Figueiredo, Luisa; Figueiredo, Luisa M.. "You shall not pass: the role of N6-methyladenosine in blocking poly(A) tail deadenylation.". Paper presented in EMBO Young Scientists' Forum., 2023.
  2. López-Escobar L; Sandra Trindade; Jakimovska-Ozdemir M; Ugur Sezerman; Figueiredo, Luisa M.. "T. brucei heterogeneity in the adipose tissue.". Paper presented in Kinetoplastid Molecular Cell Biology Meeting., 2022.
  3. Pereira da Silva, Sara; De Niz, Mariana; Serre, Karine; Ouarné, Marie; Franco, Claudio A.; Figueiredo, Luisa M.. "Trypanosome sequestration and immune response drive acute cerebral disease.". Paper presented in Kinetoplastid Molecular Cell Biology Meeting., 2022.
  4. López-Escobar, Lara; Trindade, Sandra; De Niz, Mariana; Jakimovska, Milena; Guegan, Fabien; Sezerman, F; Figueiredo, Luisa M.. "Trypanosoma brucei Heterogeneity in the Adipose Tissue". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2022.
  5. Guegan, Fabien; Bento F; Rajan SK; Pinto-Neves D; Sequeira M; Notredame C; Estevez A; Michaeli S; Figueiredo, Luisa M.. "Grumpy long non-coding RNA controls trypanosome differentiation via a smaller nucleolar RNA.". Paper presented in 32nd Molecular Parasitology Meeting, 2021.
  6. Adriana Temporão; Margarida Sanches-Vaz; Luís, Rafael; Nunes-Cabaço, Helena; Smith TK; Prudêncio, Miguel; Figueiredo, Luisa M.. "Can Trypanosoma brucei be a new ally in the fight against malaria?". Paper presented in 32nd Molecular Parasitology Meeting, 2021.
  7. Idalio J. Viegas; Macedo JP; Serra, Lúcia; Mariana De Niz; SILVA PEREIRA, SARA; Adriana Temporão; João A. Rodrigues; et al. "Poly(A) methylation of VSG genes inhibits deadenylation and increases mRNA stability.". Paper presented in 32nd Molecular Parasitology Meeting, 2021.
  8. Figueiredo, Luisa M.; Prudêncio, Miguel; Sanches-Vaz M; Temporão A. "Trypanosoma brucei proteins: new allies in the fight against malaria? Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in 31st Molecular Parasitology Meeting, 2020.
  9. Figueiredo, Luisa M.; Guegan, Fabien. "Grumpy lncRNA regulates life cycle progression of Trypanosoma brucei. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in 31st Molecular Parasitology Meeting, 2020.
  10. Figueiredo, Luisa M.; De Niz M; Trindade S. "Adipose Tissue Resident Trypanosoma brucei: a Population of Slow Growers. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in 31st Molecular Parasitology Meeting, 2020.
  11. Figueiredo, Luisa M.; De Niz M; Franco, Claudio; Bras Pedro M. "In vivo imaging reveals that establishment of tissue reservoirs by Trypanosoma brucei is multi-factorial. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in 31st Molecular Parasitology Meeting, 2020.
  12. Figueiredo, Luisa M.; Machado H, Figueiredo LM.. "Loss of fat mass during a Trypanosoma brucei infection prolongs host survival. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in 31st Molecular Parasitology Meeting, 2020.
  13. Guegan, Fabien; Bento, Fabio; Neves, Daniel; Sequeira, Mariana; Notredame, Cedric; Figueiredo, Luisa M.. "Grumpy lncRNA regulates life cycle progression of Trypanosoma brucei". Paper presented in Molecular Parasitology Meeting, 2020.
  14. Figueiredo, Luisa M.; Guegan, Fabien. "A long non-coding RNA controls parasite differentiation in African trypanosomes. Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal". Paper presented in EMBO YIP sectoral meeting in RNA and Structural biology, 2020.
  15. Trindade, Sandra; Costa-Sequeira, Mariana; De Niz, Mariana; Dejung, Mario; Bento, Fábio; Pinto-Neves, Daniel; Butter, Falk; et al. "Adipose Tissue Resident Trypanosoma brucei: a Population of Slow Growers". Paper presented in 31st Annual Molecular Parasitology Meeting, 2020.
  16. Figueiredo, Luisa M.; Viegas I; Juan Pereira de Macedo; Francisco Aresta-Branco; Samie R. Jaffrey. "Poly-A tail methylation regulates VSG transcript stability in African trypanosomes. Marine Biological Laboratory, Woods Hole, MA, USA.". Paper presented in 30th Molecular Parasitology Meeting, 2019.
  17. Figueiredo, Luisa M.; Sara Silva Pereira; Mariana De Niz. "Trypanosoma congolense cytoadheres to the brain vasculature. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in 30th Molecular Parasitology Meeting, 2019.
    10.1109/imfedk48381.2019.8950732
  18. Figueiredo, Luisa M.; Sandra Trindade; Sequeira M, Dejung, M, Bento F, Pinto-Neves D, Butter F, Bringaud F, Gjini E. "Modeling of Trypanosoma brucei population dynamics in mice reveals slow-growing parasites in adipose tissue. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2019.
  19. Figueiredo, Luisa M.; Sanches-Vaz M, Luis R, Tempora~o A., Mendes AM, Goellner S, Carvalho T, Prudencio M. "Interferon-gamma mediates inhibition of Plasmodium hepatic infection by Trypanosoma brucei. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2019.
  20. Trindade, Sandra; Costa-Sequeira, Mariana; Dejung, Mario; Bento, Fábio; Pinto-Neves, Daniel; Butter, Falk; Bringaud, Frédéric; Gjini, Erida; Figueiredo, Luisa M.. "Modeling of T. brucei Population Dynamics in Mice Reveals Slow-growing Parasites in Adipose Tissue". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2019.
  21. Guegan, Fabien; Neves, Daniel; Sequeira, Mariana; Notredame, Cedric; Figueiredo, Luisa M.. "Functional lncRNA genes in Trypanosoma brucei". Paper presented in EMBO Workshop, Molecular advances and parasite strategies in host infection, 2018.
  22. Figueiredo, Luisa M.; Guegan F, Pinto-Neves D, Sequeira M, Notredame C, Figueiredo LM.. "Genome-wide identification of lncRNA genes in Trypanosoma brucei parasite. Salve Regina University, Newport RI, USA". Paper presented in Gordon Research Conference on the Biology of Host-Parasite Interactions, 2018.
  23. Figueiredo, Luisa M.; Machado H, Figueiredo LM.. "Trypanosoma brucei mouse infection increases lipolysis in adipose tissue. Salve Regina University, Newport RI, USA". Paper presented in Gordon Research Conference on the Biology of Host-Parasite Interactions, 2018.
  24. Figueiredo, Luisa M.; Rijo-Ferreira F, Carvalho T, Afonso C, Sanches-Vaz M, Costa RM, Figueiredo LM, Takahashi JS.. "Sleeping sickness is a circadian disorder. Salve Regina University, Newport RI, USA". Paper presented in Gordon Research Conference on the Biology of Host-Parasite Interactions, 2018.
  25. Figueiredo, Luisa M.; Trindade S, Sequeira M, Dejung M, Bento F, Pinto-Neves D, Butter F, Bringaud F, Figueiredo LM.. "Adipose Tissue T. brucei Parasites Have a Reduced Proliferation State.". Paper presented in Gordon Research Conference on the Biology of Host-Parasite Interactions, 2018.
    10.5176/2315-4330_wnc17.55
  26. Guegan, Fabien; Neves, Daniel; Sequeira, Mariana; Notredame, Cedric; Figueiredo, Luisa M.. "Genome-wide identification of lncRNA genes in Trypanosoma brucei". Paper presented in Gordon conference, Biology of Host-Parasite Interaction, Eukaryotic Parasites: From Discovery Research to Clinical Interventions, 2018.
  27. Trindade, Sandra; Costa-Sequeira, Mariana; Dejung, Mario; Bento, Fábio; Pinto-Neves, Daniel; Butter, Falk; Bringaud, Frédéric; Figueiredo, Luisa M.. "In Adipose Tissue T. brucei Parasites Have a Reduced Proliferation State.". Paper presented in Gordon Research Conference on Biology of Host-Parasite Interactions, 2018.
  28. Trindade, Sandra; Costa-Sequeira, Mariana; Dejung, Mario; Bento, Fábio; Pinto-Neves, Daniel; Butter, Falk; Bringaud, Frédéric; Figueiredo, Luisa M.. "Functional Adaptation of T. brucei Parasites to the Adipose Tissue.". Paper presented in TwinntoInfect Spring School, 2018.
  29. Figueiredo, Luisa M.; Viegas I, Rodrigues JA, Nina J, Aresta-Branco F, Figueiredo LM.. "RNA modifications in a parasite. Heidelberg, Germany". Paper presented in EMBL Conference: The Epitranscriptome, 2016.
  30. Figueiredo, Luisa M.; Trindade S, Rijo-Ferreira F, Carvalho T, Pinto-Neves D, van Den Abbeele J, Ribeiro MR, Dias S, Figueiredo LM.. "Metabolic consequences of trypanosome parasite accumulation in adipose tissue. Waterville Valley, NH, USA". Paper presented in Gordon Research Conference on the Molecular & Cellular Biology of Lipids., 2015.
  31. Figueiredo, Luisa M.. "Keeping an open chromatin in the active VSG expression site is associated to uncommitted switching. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2015.
    10.1109/ecce.2010.5618280
  32. Trindade, Sandra; Rijo-Ferreira, Filipa; Carvalho, Tânia; Pinto-Neves, Daniel; Van Den Abbeele, Jan; Ribeiro, Ruy M.; Dias, Sérgio; Figueiredo, Luisa M.. "Metabolic Consequences of Trypanosome Parasite Accumulation in Adipose Tissue". Paper presented in iMM 3rd Postdoc Day, 2015.
  33. Figueiredo, Luisa M.; Rijo-Ferreira F. "CleverSys HomeCageScan: what is your mouse doing when you’re not looking? EMBL campus. Heidelberg, Germany". Paper presented in EMBO Young Investigator PhD Course 2014, 2014.
  34. Figueiredo, Luisa M.; Rijo-Ferreira F, Takahashi JS, Figueiredo LM.. "Trypanosoma brucei accelerates the mouse circadian clock. Big Sky, Montana, United States of America". Paper presented in Society for Research on Biological Rhythms, 2014.
  35. Figueiredo, Luisa M.; Maia-Silva D, Guegan F, Figueiredo LM.. "Do long noncoding RNAs regulate T. brucei differentiation? Lisbon, Portugal". Paper presented in Annual International Medical Students (AIMS) meeting, 2013.
  36. Figueiredo, Luisa M.; Aresta-Branco F. "Formaldehyde-assisted isolation of regulatory elements (FAIRE): where is “open chromatin”? EMBL campus. Heidelberg, Germany". Paper presented in EMBO Young Investigator PhD Course 2013, 2013.
  37. Figueiredo, Luisa M.; Manso H, Neves D, Pimentel M, Pena AC, Figueiredo LM. "Histone H1 depletion controls trans-splicing in Trypanosoma brucei. European Bioinformatics Institute, Cambridge, United Kingdom". Paper presented in EMBO Practical Course Analysis of High-Throughput Sequencing Data., 2013.
  38. Figueiredo, Luisa M.; Ferreira AF, Carvalho T, Trindade S, Takahashi JS, Figueiredo LM.. "A mouse model to study circadian rhythm changes during an infection by Trypanosoma brucei. Janelia Farm Research Campus, Ashburn, Virginia, USA". Paper presented in HHMI Science meeting 2013, 2013.
  39. Figueiredo, Luisa M.; Ferreira AF, Carvalho T, Trindade S, Takahashi JS, Figueiredo LM.. "A mouse model to study circadian rhythm changes during an infection by Trypanosoma brucei. Ludwig-Maximilians-University, Munich, Germany". Paper presented in European Biological Rhythms Society, 2013.
  40. Figueiredo, Luisa M.; Aresta-Branco F, Pimentel M, Figueiredo LM.. "Open chromatin of the VSG Expression Site is maintained independently of transcription in Trypanosoma brucei. Instituto de Medicina Molecular, Lisbon, Portugal". Paper presented in EMBO Young Scientists' Forum, 2013.
  41. Figueiredo, Luisa M.; Guegan F, Kedra DA, Notredame C, Figueiredo LM.. "Long non-coding RNA in Trypanosoma brucei parasites. Instituto de Medicina Molecular, Lisbon, Portugal". Paper presented in EMBO Young Scientists' Forum, 2013.
    10.17143/ciaed/xxiilciaed.2017.00136
  42. Figueiredo, Luisa M.; Trindade S, Carvalho T, Ferreira AF, Itoe MA, Figueiredo LM.. "Tissue tropism of Trypanosoma brucei: causes and consequences. Instituto de Medicina Molecular, Lisbon, Portugal". Paper presented in EMBO Young Scientists' Forum, 2013.
  43. Figueiredo, Luisa M.; Vaz MS, Mendes AM, Figueiredo LM, Prudêncio M.. "Trypanosomes inhibit Plasmodium liver stage. Instituto de Medicina Molecular, Lisbon, Portugal". Paper presented in EMBO Young Scientists' Forum, 2013.
  44. Figueiredo, Luisa M.; Pena AC, Pimentel M, Manso H, Ferreira AF, Neves D, Aresta-Branco F, Guegan F, Coelho LP, Figueiredo LM.. "Histone H1 controls the expression of a specific set of genes and it is important for virulence of African trypanosomes. Instituto de Medicina Molecular, Lisbon, Portugal". Paper presented in EMBO Young Scientists' Forum, 2013.
  45. Guegan, Fabien; Kedra, DA; Notredame, Cedric; Figueiredo, Luisa M.. "Long non-coding RNA in Trypanosoma brucei parasites.". Paper presented in EMBO Young Scientists' Forum, 2013.
  46. Trindade, Sandra; Carvalho, Tânia; Rijo-Ferreira, Filipa; Itoe, Maurice; Figueiredo, Luisa M.. "Tissue Tropism of Trypanosoma brucei: Causes and Consequences". Paper presented in EMBO Young Scientists Forum, 2013.
  47. Figueiredo, Luisa M.; Pimenta S, Aresta-Branco F, Figueiredo LM.. "Geração de linha repórter para estudo da variação antigénica em Trypanosoma brucei. Lisbon, Portugal". Paper presented in 15º Workshop Educação pela Ciência, 2012.
  48. Figueiredo, Luisa M.; Pimentel M, Pena A, Figueiredo LM.. "Cell-cycle expression of histone H1 variants in Trypanosoma brucei. Nice, France.". Paper presented in The EMBO meeting 2012, 2012.
  49. Figueiredo, Luisa M.; Aresta-Branco F, Pimentel M, Figueiredo LM.. "Open chromatin conformation is independent of RNA polymerase I transcription in Trypanosoma brucei. Howard Hughes Medical Institute. Ashburn, USA". Paper presented in Nucleic Acids And Interacting Proteins, 2012.
  50. Guegan, Fabien; Figueiredo, Luisa M.. "Do Non-coding RNAs regulate antigenic variation in Trypanosoma brucei?". Paper presented in FEBS Workshop on Non-coding RNA in Transcription, Chromatin and Epigenetics, 2012.
  51. Figueiredo, Luisa M.; Pimenta S, Aresta-Branco F, Figueiredo LM.. "VSG expression in Trypanosoma brucei using a tetracyclin-inducible system. Lisbon, Portugal". Paper presented in Annual International Medical Students (AIMS) meeting, 2012.
  52. Figueiredo, Luisa M.; Pena A, Ferreira AF, Figueiredo LM.. "Histone H1 controls variant surface glycoprotein silencing in African trypanosomes. Vienna, Austria". Paper presented in The 3rd EMBO meeting, 2011.
  53. Figueiredo, Luisa M.. "What can we learn about sleep by studying parasites? Turin, Italy". Paper presented in ESOF, 2010.
  54. Figueiredo, Luisa M.; Cross GAM. "Active VSG Expression Site is organized in a uniquely open chromatin structure. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2009.
  55. Figueiredo, Luisa M.. "The bloodstream form VSG expression site repertoire of Trypanosoma brucei strain 427 Hertz. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2007.
  56. Figueiredo, Luisa M.; Figueiredo LM, Teng G, Cross GAM.. "50-bp repeats are not required to maintain the active status of a VSG Expression Site in T. brucei. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2005.
  57. Figueiredo, Luisa M.; Scherf A.. "The unusually large Plasmodium telomerase localises to a discrete compartment associated with the nucleolus. Marine Biological Laboratory, Woods Hole, MA, USA". Paper presented in XIV Molecular Parasitology Meeting, 2004.
  58. Figueiredo, Luisa M.; Figueiredo LM, Pirrit LA, Emmanuel B, Scherf A.. "Characterization of Plasmodium falciparum telomeres: length variation between individual chromosomes. Cold Spring Harbor Laboratory, New York, USA". Paper presented in Telomeres & Telomerase meeting, 1999.
Journal article
  1. Henrique Machado; Peter Hofer; Rudolf Zechner; Terry K. Smith; Luísa M. Figueiredo. "Adipocyte lipolysis protects mice against Trypanosoma brucei infection". Nature Microbiology (2023): https://doi.org/10.1038/s41564-023-01496-7.
    10.1038/s41564-023-01496-7
  2. Idálio J. Viegas; Luisa M. Figueiredo. "From trans-splicing discovery and onwards, trypanosomes lead the way". Nature Reviews Molecular Cell Biology (2022): https://doi.org/10.1038/s41580-022-00489-4.
    10.1038/s41580-022-00489-4
  3. Silva Pereira, Sara; Jackson, Andrew P.; Figueiredo, Luísa M.. "Evolution of the variant surface glycoprotein family in African trypanosomes". Trends in Parasitology 38 1 (2022): 23-36. http://dx.doi.org/10.1016/j.pt.2021.07.012.
    10.1016/j.pt.2021.07.012
  4. De Niz, Mariana; Silva Pereira, Sara; Serre, Karine; Ouarné, Marie; Coelho, Joana E; Franco, Claudio; Figueiredo, Luisa M.. "Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis". (2022): http://hdl.handle.net/10451/55386.
    10.7554/eLife.77440
  5. Monic, S. G.; Lamy, A.; Thonnus, M.; Bizarra-Rebelo, T.; Bringaud, F.; Smith, T. K.; Figueiredo, Luisa M.; Rivière, L.. "A novel lipase with dual localisation in Trypanosoma brucei". (2022): http://hdl.handle.net/10451/52028.
    10.1038/s41598-022-08546-w
  6. Viegas, Idálio; Macedo, Juan; Serra, Lúcia; De Niz, Mariana; Temporão, Adriana; Silva Pereira, Sara; Mirza, Aashiq H.; et al. "N6-methyladenosine in poly(A) tails stabilize VSG transcripts". bioRxiv (2022): http://hdl.handle.net/10451/52176.
    10.1038/s41586-022-04544-0
  7. Trindade, Sandra; De Niz, Mariana; Sequeira, Mariana; Rebelo, Tiago; Bento, Fabio; Dejung, Mario; Narciso, Marta Valido; et al. "Slow growing behavior in African trypanosomes during adipose tissue colonization". (2022): http://hdl.handle.net/10451/56325.
    10.1038/s41467-022-34622-w
  8. Adriana Temporão; Katerina Artavanis-Tsakonas; Margarida Sanches-Vaz; Rafael Luís; Helena Nunes-Cabaço; Terry K. Smith; Miguel Prudêncio; Luisa M. Figueiredo. "Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection". PLOS Neglected Tropical Diseases 15 10 (2021): e0009912-e0009912. https://doi.org/10.1371/journal.pntd.0009912.
    10.1371/journal.pntd.0009912
  9. Fabien Guegan; Luisa Figueiredo. "A two-stage solution". eLife (2021): https://doi.org/10.7554/eLife.72980.
    10.7554/eLife.72980
  10. Mariana De Niz; Daniela Brás; Marie Ouarné; Mafalda Pedro; Ana M. Nascimento; Lenka Henao Misikova; Claudio A. Franco; et al. "Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence". Cell Reports 36 12 (2021): 109741-109741. https://doi.org/10.1016/j.celrep.2021.109741.
    10.1016/j.celrep.2021.109741
  11. Luzak V; López-Escobar L; Siegel TN; Figueiredo LM. "Cell-to-Cell Heterogeneity in Trypanosomes.". Annual review of microbiology (2021): http://europepmc.org/abstract/med/34228491.
    10.1146/annurev-micro-040821-012953
  12. Henrique Machado; Luisa M. Figueiredo. "Polyreactive Antibodies Bridge Immunity Particles to Pathogen". Trends in Parasitology (2020): https://doi.org/10.1016/j.pt.2020.07.012.
    10.1016/j.pt.2020.07.012
  13. F. Guegan; F. Bento; D. Neves; M. Sequeira; C. Notredame; L.M. Figueiredo; Guegan, Fabien Marc; et al. "A long non-coding RNA controls parasite differentiation in African trypanosomes". bioRxiv (2020): https://doi.org/10.1101/2020.05.03.074625.
    10.1101/2020.05.03.074625
  14. Figueiredo, Luisa M.. "Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs". Molecules (2019): http://dx.doi.org/10.3390/molecules25010066.
    10.3390/molecules25010066
  15. Margarida Sanches-Vaz; Christian R. Engwerda; Adriana Temporão; Rafael Luis; Helena Nunes-Cabaço; António M. Mendes; Sarah Goellner; et al. "Trypanosoma brucei infection protects mice against malaria". PLOS Pathogens 15 11 (2019): e1008145-e1008145. https://doi.org/10.1371/journal.ppat.1008145.
    10.1371/journal.ppat.1008145
  16. Francisco Aresta-Branco; Margarida Sanches-Vaz; Fabio Bento; João A. Rodrigues; Luisa M. Figueiredo. "African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system". Proceedings of the National Academy of Sciences 116 41 (2019): 20725-20735. https://doi.org/10.1073/pnas.1905120116.
    10.1073/pnas.1905120116
  17. Carvalho T; Santos AM; Figueiredo LM. "Detection of Extravascular Trypanosoma Parasites by Fine Needle Aspiration.". Journal of visualized experiments : JoVE (2019): http://europepmc.org/abstract/med/31449256.
    10.3791/59798
  18. Sara Silva Pereira; Sandra Trindade; Mariana De Niz; Luisa M. Figueiredo. "Correction to ‘Tissue tropism in parasitic diseases’". Open Biology 9 6 (2019): 190124-190124. https://doi.org/10.1098/rsob.190124.
    10.1098/rsob.190124
  19. Luisa Miranda Figueiredo. "Cellular microbiology interview - Luisa Figueiredo". Cellular Microbiology (2019): https://doi.org/10.1111/cmi.13073.
    10.1111/cmi.13073
  20. Sara Silva Pereira; Sandra Trindade; Mariana De Niz; Luisa M. Figueiredo. "Tissue tropism in parasitic diseases". Open Biology (2019): https://doi.org/10.1098/rsob.190036.
    10.1098/rsob.190036
  21. Mariana De Niz; Gavin R. Meehan; Nicolas M.B. Brancucci; Matthias Marti; Brice Rotureau; Luisa M. Figueiredo; Friedrich Frischknecht. "Intravital imaging of host–parasite interactions in skin and adipose tissues". Cellular Microbiology (2019): e13023-e13023. https://doi.org/10.1111/cmi.13023.
    10.1111/cmi.13023
  22. Tânia Carvalho; Alvaro Acosta-Serrano; Sandra Trindade; Sílvia Pimenta; Ana B. Santos; Filipa Rijo-Ferreira; Luísa M. Figueiredo; et al. Corresponding author: Luisa M. Figueiredo. "Trypanosoma brucei triggers a marked immune response in male reproductive organs". PLOS Neglected Tropical Diseases 12 8 (2018): e0006690-e0006690. https://doi.org/10.1371/journal.pntd.0006690.
    10.1371/journal.pntd.0006690
  23. Figueiredo, Luisa; Filipa Rijo-Ferreira; Tânia Carvalho; Cristina Afonso; Margarida Sanches-Vaz; Rui M Costa; Luísa M. Figueiredo; Joseph S. Takahashi. "Sleeping sickness is a circadian disorder". Nature Communications (2018): https://doi.org/10.1038/s41467-017-02484-2.
    10.1038/s41467-017-02484-2
  24. Filipa Rijo-Ferreira; Joseph S. Takahashi; Luisa M. Figueiredo; Laurie Read. "Circadian rhythms in parasites". PLOS Pathogens 13 10 (2017): e1006590-e1006590. https://doi.org/10.1371%2Fjournal.ppat.1006590.
    10.1371/journal.ppat.1006590
  25. Filipa Rijo-Ferreira; Daniel Pinto-Neves; Nuno L. Barbosa-Morais; Joseph S. Takahashi; Luisa M. Figueiredo. "Trypanosoma brucei metabolism is under circadian control". Nature Microbiology 2 6 (2017): https://doi.org/10.1038/nmicrobiol.2017.32.
    10.1038/nmicrobiol.2017.32
  26. Terry K. Smith; Frédéric Bringaud; Derek P. Nolan; Luisa M. Figueiredo. "Metabolic reprogramming during the Trypanosoma brucei life cycle". F1000Research 6 (2017): 683-683. https://doi.org/10.12688/f1000research.10342.1.
    10.12688/f1000research.10342.1
  27. Figueiredo, Luisa. "Metabolic reprogramming during the Trypanosoma brucei life cycle [version 2; referees: 4 approved]". (2017): https://f1000research.com/articles/6-683/v2.
    10.12688/f1000research.10342.2
  28. Figueiredo, Luisa. "Luísa Figueiredo – The Parasite in the Fat: A Serendipitous Finding". Trends in Parasitology 33 4 (2017): 255-255. https://doi.org/10.1016%2Fj.pt.2017.01.012.
    10.1016/j.pt.2017.01.012
  29. Tanowitz HB; Scherer PE; Mota MM; Figueiredo LM. "Adipose Tissue: A Safe Haven for Parasites?". (2016): http://europepmc.org/abstract/med/28007406.
    10.1016/j.pt.2016.11.008
  30. Cicova Z; Dejung M; Skalicky T; Eisenhuth N; Hanselmann S; Morriswood B; Figueiredo LM; Butter F; Janzen CJ. "Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation.". (2016): http://europepmc.org/abstract/med/27779220.
    10.1038/srep35826
  31. Trindade S; Rijo-Ferreira F; Carvalho T; Pinto-Neves D; Guegan F; Aresta-Branco F; Bento F; et al. "Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.". (2016): http://europepmc.org/abstract/med/27237364.
    10.1016/j.chom.2016.05.002
  32. Aresta-Branco F; Pimenta S; Figueiredo LM. "A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei.". (2016): http://europepmc.org/abstract/med/26673706.
    10.1093/nar/gkv1459
  33. Pena AC; Pimentel MR; Manso H; Vaz-Drago R; Pinto-Neves D; Aresta-Branco F; Rijo-Ferreira F; et al. "Trypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo.". (2014): http://europepmc.org/abstract/med/24946224.
    10.1111/mmi.12677
  34. Figueiredo, L.M.; Cross, G.A.M.. "Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes". Eukaryotic Cell 9 1 (2010): 148-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-75649110809&partnerID=MN8TOARS.
    10.1128/EC.00282-09
  35. Boothroyd, C.E.; Dreesen, O.; Leonova, T.; Ly, K.I.; Figueiredo, L.M.; Cross, G.A.M.; Papavasiliou, F.N.. "A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei". Nature 459 7244 (2009): 278-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149135713&partnerID=MN8TOARS.
    10.1038/nature07982
  36. Siegel, T.N.; Hekstra, D.R.; Kemp, L.E.; Figueiredo, L.M.; Lowell, J.E.; Fenyo, D.; Wang, X.; Dewell, S.; Cross, G.A.M.. "Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei". Genes and Development 23 9 (2009): 1063-1076. http://www.scopus.com/inward/record.url?eid=2-s2.0-65449138352&partnerID=MN8TOARS.
    10.1101/gad.1790409
  37. Yang, X.; Figueiredo, L.M.; Espinal, A.; Okubo, E.; Li, B.. "RAP1 Is Essential for Silencing Telomeric Variant Surface Glycoprotein Genes in Trypanosoma brucei". Cell 137 1 (2009): 99-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-63049115947&partnerID=MN8TOARS.
    10.1016/j.cell.2009.01.037
  38. Figueiredo, L.M.; Cross, G.A.M.; Janzen, C.J.. "Epigenetic regulation in African trypanosomes: A new kid on the block". Nature Reviews Microbiology 7 7 (2009): 504-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649397588&partnerID=MN8TOARS.
    10.1038/nrmicro2149
  39. Figueiredo, L.M.; Janzen, C.J.; Cross, G.A.M.. "A histone methyltransferase modulates antigenic variation in African trypanosomes". PLoS Biology 6 7 (2008): 1539-1548. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349107004&partnerID=MN8TOARS.
    10.1371/journal.pbio.0060161
  40. Hertz-Fowler, C.; Figueiredo, L.M.; Quail, M.A.; Becker, M.; Jackson, A.; Bason, N.; Brooks, K.; et al. "Telomeric expression sites are highly conserved in Trypanosoma brucei". PLoS ONE 3 10 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-55849146248&partnerID=MN8TOARS.
    10.1371/journal.pone.0003527
  41. Figueiredo, L.M.; Rocha, E.P.C.; Mancio-Silva, L.; Prevost, C.; Hernandez-Verdun, D.; Scherf, A.. "The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus". Nucleic Acids Research 33 3 (2005): 1111-1122. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844304405&partnerID=MN8TOARS.
    10.1093/nar/gki260
  42. Figueiredo, L.; Scherf, A.. "Plasmodium telomeres and telomerase: The usual actors in an unusual scenario". Chromosome Research 13 5 (2005): 517-524. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944466984&partnerID=MN8TOARS.
    10.1007/s10577-005-0996-3
  43. Figueiredo, L.M.; Freitas Jr., L.H.; Bottius, E.; Olivo-Marin, J.-C.; Scherf, A.. "A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation". EMBO Journal 21 4 (2002): 815-824. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037083982&partnerID=MN8TOARS.
    10.1093/emboj/21.4.815
  44. Scherf, A.; Figueiredo, L.M.; Freitas-Junior, L.H.. "Plasmodium telomeres: A pathogen's perspective". Current Opinion in Microbiology 4 4 (2001): 409-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034905102&partnerID=MN8TOARS.
    10.1016/S1369-5274(00)00227-7
  45. Figueiredo, L.M.; Pirritt, L.A.; Scherf, A.. "Genomic organisation and chromatin structure of Plasmodium falciparum chromosome ends". Molecular and Biochemical Parasitology 106 1 (2000): 169-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033972531&partnerID=MN8TOARS.
    10.1016/S0166-6851(99)00199-1
  46. Hatton, L.S.; Eloranta, J.J.; Figueiredo, L.M.; Takagaki, Y.; Manley, J.L.; O'Hare, K.. "The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene". Nucleic Acids Research 28 2 (2000): 520-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034650189&partnerID=MN8TOARS.
  47. Figueiredo, L.M.; Pirrit, L.A.; Scherf, A.. "Erratum: Genomic organisation and chromatin structure of Plasmodium falciparum chromosome ends (Molecular Biochemical Parasitology (2000) 106 (169-174) PII: S0166685199001991)". Molecular and Biochemical Parasitology 109 1 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0033869041&partnerID=MN8TOARS.
    10.1016/S0166-6851(00)00239-5
Preprint
  1. Alexander K. Beaver; Nathan P. Crilly; Gracyn Y. Buenconsejo; Jill M.C. Hakim; Bailin Zhang; Bryce Bobb; Filipa Rijo-Ferreira; Luisa M. Figueiredo; Monica R. Mugnier. "Extravascular spaces are the primary reservoir of antigenic diversity inTrypanosoma bruceiinfection". 2022. https://doi.org/10.1101/2022.06.27.497797.
    10.1101/2022.06.27.497797
  2. S Monic; A Lamy; M Thonnus; T Bizarra-Rebelo; F Bringaud; TK Smith; LM Figueiredo; L Rivière. "A novel lipase with dual localisation in Trypanosoma brucei". 2022. https://doi.org/10.1101/2022.02.23.481587.
    10.1101/2022.02.23.481587
  3. Henrique Machado; Peter Hofer; Rudolf Zechner; Luísa M. Figueiredo. "Adipocyte lipolysis protects the host againstTrypanosoma bruceiinfection". 2022. https://doi.org/10.1101/2022.11.05.515274.
    10.1101/2022.11.05.515274
Thesis / Dissertation
  1. Narciso, Marta Valido. "Tissue tropism and parasite virulence in recently isolated Trypanosoma brucei strains". Master, 2023. http://hdl.handle.net/10451/61144.
  2. "Adipocyte and T. brucei adaptations in a co-culture setting.". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2022.
  3. Pereira, Ana Raquel Santos. "Adipocyte metabolic response to Trypanosoma brucei in a co-culture setting". Master, 2022. http://hdl.handle.net/10362/131417.
  4. "Understanding how African trypanosomes impair a subsequent Plasmodium infection.". PhD, Instituto de Medicina Molecular, 2021.
  5. "Longitudinal analysis of adipocytes and liver gene expression during T. brucei infection?". Master, Universidade de Lisboa Faculdade de Ciências, 2020.
  6. "How do parasites remodel their metabolism?". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2019.
  7. "Understanding the role of glycerol in triggering parasite differentiation.". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2018.
  8. "Exploring the role of metabolic enzymes in parasite fat tropism". Master, IMC Fachhochschule Krems, 2018.
  9. "Using proteomics to understand how parasites adapt to the host environment.". Master, Universidade de Lisboa Instituto Superior Técnico, 2017.
  10. "Deciphering parasite persistence in adipose tissue.". Master, 2017.
  11. "Trypanosoma brucei distribution in the male reproductive system.". Master, Universidade de Lisboa Faculdade de Medicina, 2017.
  12. "Understanding chromatin dynamics during antigenic variation in Trypanosoma brucei.". PhD, Universidade de Lisboa Faculdade de Medicina, 2016.
  13. "Understanding the role of parasites epitranscriptome.". Master, Universidade de Lisboa Faculdade de Ciências, 2016.
  14. "Post-transcriptional circadian gene expression regulation in Trypanosoma brucei.". Master, Universidade de Lisboa Faculdade de Ciências, 2016.
  15. "Circadian rhythms in a Trypanosoma brucei infection: host, parasite or both?". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2016.
  16. "Role of histone H1 in chromatin and gene expression in the African Trypanosome: broad skills, specific functions?". PhD, Universidade de Lisboa Faculdade de Medicina, 2015.
  17. "Role of long non-coding RNAs in parasite differentiation.". Master, Universidade de Lisboa Faculdade de Ciências, 2015.
  18. "N6-methyladenosine: a new modification in T. brucei.". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2014.

Intellectual property

Patent
  1. Figueiredo, Luisa M.. 2018. "Método de diagnóstico de tripanossomíase animal". Portugal.
    Pending
Provisional application for patent
  1. 2023. "METHODS OF RNA STABILISATION".

Other

Other output
  1. Immunopathology and parasite sequestration cause severe cerebral trypanosomiasis in animals. 2021. Sara Silva Pereira; Mariana De Niz; Karine Serre; Marie Ouarné; Claudio A Franco; Luisa M Figueiredo. https://doi.org/10.21203/rs.3.rs-1050698/v1.
    10.21203/rs.3.rs-1050698/v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12/12 Hidden wonders in Trypanosoma biology. Seminar series
Université de Montpellier. (Montpellier, France)
2023/12/11 Learning new biology by studying an ancient parasite. Journée du Département Sciences Biologiques et Médicales.
Université de Bordeaux (Bordeaux, France)
2023/12/01 Breaking Barriers in Tissue Tropism. Seminar series
Universidade de São Paulo
2023/11/22 Unveiling the impact of trypanosome infection on adipose tissue. MicrobUP Webinar.
Institut Cochin (France)
2023/10/26 Uncovering the unusual biology of trypanosomes. EMBO members’ meeting.
EMBL (Heidelberg, Germany)
2023/05/12 Invasion and Adaptation: Exploring Trypanosoma brucei’s Phenotypic Flexibility in Host Tissues. Biomedical Science Seminars.
University of York (York, United Kingdom)
2023/01/26 A small RNA modification that prolongs the life of a messenger RNA. RNA IN DISEASE IX ptRNA meeting.
Instituto de Medicina Molecular (Lisboa, Portugal)
2022/10/06 Functional modifications in the tails of messenger RNAs. Seminar series
Institut Pasteur (Paris, France)
2022/09/22 Antigenic variation in African trypanosomes: small RNA modifications, big impact. SymbNET seminar series
IGC (Oeiras, Portugal)
2022/05/22 Another Trypanosoma lesson on RNA biology. Seminar series. Virtual meeting
University of Heidelberg
2022/05/20 RNA modifications: Sugar and Spice. Hot Topics Webinar, Virtual meeting.
Sociedade Portuguesa de Genética
2022/04/21 Trypanosoma’s lesson on RNA biology. Seminar series. Virtual meeting
Johns Hopkins University
2022/04/05 RNA modifications at the Poly(A) tail of mRNA. EMBO eTalk
Instituto de Medicina Molecular João Lobo Antunes (Lisboa, Portugal)
2022/03/22 Passion for parasites. EMBO Young Investigator PhD course
EMBO (Heidelberg, Germany)
2022/01/28 Living Inside Adipose Tissue. 38th Annual Swiss Trypanosomatid Meeting
University of Bern
2022/01/27 N6-methyladenosine in poly(A) tails stabilize VSG transcripts. 38th Annual Swiss Trypanosomatid Meeting
University of Bern
2021/07/02 Poly(A) tail methylation stabilizes VSG transcripts. EMBO YIP meeting
Instituto de Medicina Molecular (Lisboa, Portugal)
2021/06/17 Poly(A) tail methylation stabilizes key virulence transcripts in African trypanosomes. Online Meeting on Epigenetics in the Biology of Parasites
Israeli Society for Parasitology, Protozoology and Tropical Diseases (Israel)
2021/04/20 Tissue tropisms in the mammalian host. Swiss TPH - Virtual meeting
Swiss Tropical and Public Health Institute (Bern, Switzerland)
2020/09/02 Strategies to identify the mechanism of poly(A) methylation. EMBO YIP sectoral meeting in RNA and Structural biology
Instituto de Medicina Molecular João Lobo Antunes (Lisboa, Portugal)
2020/01/10 Tissue tropisms in the mammalian host. TsetseNET meeting
West African Centre for Cell Biology and Infectious Pathogens (WACCBIP) (Ghana)
2019/06/14 Investigating Trypanosoma brucei dynamics in living mammalian hosts. 2019 EMBO Fellows’ Meeting
EMBL (Heidelberg, Germany)
2019/05 Unexpected phenotypic variability of Trypanosoma brucei parasites. 9th Meeting ACETOTRYP/GLYCONOV
(Bombannes, France)
2019/03/27 African Trypanosomes: masters of adaptation to the environment
CEDOC - Chronic Diseases Research Center (Lisboa, Portugal)
2019/03/04 African trypanosomes: masters of adaption to the environment.
HELSINKI INSTITUTE OF LIFE SCIENCE (Helsínquia, Finland)
2019/01/16 New discoveries in Trypanosome biology.
The West African Centre for Cell Biology of Infectious Pathogens. University of Ghana (Ghana)
2018/11/12 Unexpected phenotypic variability of Trypanosoma brucei parasites.
Ludwig Maximilian University (Munich, Germany)
2018/10/30 RNA modifications in parasite immune evasion.
Weill Medical College, Cornell University (New York, United States)
2018/10/02 Tissue immunity against African trypanosomes. EMBO Workshop on Molecular advances and parasite strategies in host infection
EMBO (Les Embiez Island, France)
2018/08/21 Unexpected phenotypic variability of Trypanosoma brucei parasites.
Liverpool School of Tropical Medicine. University of Liverpool (Liverpool, United Kingdom)
2018/07/07 Living inside and outside blood circulation. Workshop on Biophysical Constraints and Evolutionary Cell Biology.
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2018/06/15 What can Trypanosomes teach us about the role of adipose tissue in infections?
Cell Press (Cambridge, MA, United States)
2018/02/02 Sleeping sickness is a circadian disease. JorTec
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Monte de Caparica, Portugal)
2018/01/11 Parasites in blood and adipose tissue are phenotypically different. Livestock trypanosome symposium.
University of Edinburgh (Edinburgh, United Kingdom)
2017/12/21 Parasites that cause jet lag in the host. Symposium 10th anniversary Masters in Evolutionary and Developmental Biology.
Faculdade de Ciências, Universidade de Lisboa, (Lisboa, Portugal)
2017/12/06 Unexpected phenotypic variability of Trypanosoma brucei parasites.
CNC – Center for Neuroscience and Cell Biology seminars. (Coimbra, Portugal)
2017/11 Adipose tissue: a safe haven for Trypanosoma brucei. USP Symposium
Universidade de São Paulo (Butantã, São Paulo, Brazil)
2017/07/05 Parasites have clocks. Encontro Nacional da Ciência
Centro Congressos de Lisboa (Lisboa, Portugal)
2017/06/30 Unexpected phenotypic variability of parasites occupying the adipose tissue.
The Crick Institute (London, United Kingdom)
2017/06/06 T. brucei gene expression is under circadian control.
University of Wuerzburg (Wuerzburg, Germany)
2017/06/05 Gene expression of Trypanosoma parasites is under space and circadian control. EMBO meeting on Hijacking host cell signalling and epigenetic mimicry during Infections.
The Pasteur Institute (Paris, France)
2016/09 Parasites in blood and adipose tissue are phenotypically different. 1st Expert Meeting on T.B. gambiense Human Trypanotolerance and Animal Reservoir.
(Îles des Embiez, Marseille, France)
2016/05 African Trypanosomes: a new life beyond the bloodstream. IV Trypanosomatid parasites: From the Field to the Lab.
Institut Pasteur (Paris, France)
2016/04/28 African Trypanosomes: a new life beyond the bloodstream. Infection External Seminars at Institute of Infection, Immunity and Inflammation.
University of Glasgow (Glasgow, United Kingdom)
2016/04/27 African Trypanosomes: a new life beyond the bloodstream. Institute of Immunology and Infection Research Seminar Series.
University of Edinburgh (Edinburgh, United Kingdom)
2016/04/04 African Trypanosomes: a new life beyond the bloodstream. Seminar Trypanosomes at Institute of Cell Biology.
University of Bern ( Bern, Switzerland)
2016/03/10 African Trypanosomes: a new life beyond the bloodstream.
CEDOC - Chronic Diseases Research Center (Lisboa, Portugal)
2016/03/04 Bio-informatics: a key to discover new biology in disease. II Semana de Bioengenharia.
Instituto Superior Técnico (Lisboa, Portugal)
2016/01/22 Trypanosome parasites: a new life beyond the bloodstream.
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2015/12/01 Consequences of Trypanosoma brucei accumulation in adipose tissue. (oral presentation by Sandra Trindade) Vectors and parasites in Global Health
Instituto de Higiene e Medicina Tropical (Lisboa, Portugal)
2015/09/21 Adipose tissue is the main target organ in Trypanosoma brucei infection. 47th Trypanosomatid Metabolism microsymposium
The Institute of Infection, Immunity and Inflammation (Glasgow, United Kingdom)
2015/06/01 Trypanosomes accelerate the host circadian rhythm. Oberseminar
Institute of Medical Psychology. Ludwig Maximilians University (Munique, Germany)
2015/04 Adipose tissue is where most Trypanosoma brucei parasites accumulate and a probable source of relapse after treatment. Kinetoplastid Molecular Cell Biology Meeting
Marine Biological Laboratory (Woods Hole, MA, United States)
2014/11 Trypanosoma brucei accelerates the mouse internal clock. XVII Congresso Português de Parasitologia
(Coimbra, Portugal)
2014/06 Chromatin dynamics in Trypanosomes.
Institut Pasteur (Paris, France)
2013/07/15 Chromatin dynamics and VSG gene regulation in African trypanosomes. EMBO Young Scientists’ Forum
Instituto de Medicina molecular (Lisboa, Portugal)
2013/03/01 Functions of lncRNA and histone H1 in T. brucei.
Centre for Genomic Regulation (Barcelona, Spain)
2013/01/25 Chromatin and antigenic variation in T. brucei. 30th Annual Swiss Trypanosomatid Meeting
(Leysin, Switzerland)
2013/01/24 Histone H1 regulates a specific set of genes and is important for virulence in Trypanosoma brucei. (Oral communication by Pena AC) 30th Annual Swiss Trypanosomatid Meeting
(Leysin, Switzerland)
2012/10/11 Starting as a Principal Investigator. IGC Postdoc Meeting 2012
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2012/10/11 Keynote Lecture: Chromatin dynamics in African Trypanosoma. 3rd ITQB PhD Students’ Meeting
Instituto de Tecnologia Química e Biológica (Oeiras, Portugal)
2012/07/06 Chromatin dynamics in Trypanosoma brucei. Symposium on Molecular Parasitology in honor of Professor George A. M. Cross FRS
(Cambridge, United Kingdom)
2012/06/13 Chromatin dynamics and antigenic variation in T. brucei.
University of Wuerzburg (Wuerzburg, Germany)
2012/06/11 Chromatin dynamics and antigenic variation in T. brucei.
Ludwig-Maximilian University (Munique, Germany)
2012/05/08 Dynamics of chromatin conformation in African trypanosomes. 12th EMBO Young Investigator Meeting
Instituto Gulbenkian de Ciência and Fundação Champalimaud (Oeiras and Lisboa, Portugal)
2011/12/02 The role of chromatin in antigenic variation of African Trypanosomes. Microbiotec11 meeting
(Braga, Portugal)
2011/07/11 Histone H1 modulates antigenic variation of African Trypanosomes.
University of Regensburg (Regensburg, Germany)
2011/05/17 Histone H1 modulates antigenic variation in African trypanosomes. 11th EMBO Young Investigator meeting
EMBL (Heidelberg, Germany)
2011/01/17 The role of chromatin in antigenic variation of African Trypanosomes. Royal Society Subtelomere meeting
( Buckinghamshire, United Kingdom)
2010 Epigenetics of antigenic variation: defining new drug targets to make African trypanosomes more susceptible to the host immune response. Annual Meeting of the American Society for Tropical Medicine & Hygiene
( Atlanta, GA,, United States)
2010 The role of chromatin in antigenic variation of African Trypanosomes.
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2010 The role of chromatin in antigenic variation of African Trypanosomes.
Instituto de Higiene e Medicina Tropical (Lisboa, Portugal)
2008/06 A histone methyltransferase modulates antigenic variation in African trypanosomes. Gordon Research Conference – Biology of Host-Parasite Interactions
Gordon Research Conferences (Newport, RI, United States)
2007/04 Histone H3K76 methyltransferase DOT1B modulates monoallelic VSG expression in T. brucei. Kinetoplastid Molecular Cell Biology Meeting
Marine Biological Laboratory (Woods Hole, MA, United States)
2007 Histone methylation modulates monoallelic expression of antigenic variation genes in Trypanosomes.
Institute for Molecular and Cellular Biology (Port, Portugal)
2002/09 The unusually large Plasmodium telomerase reverse-transcriptase localises in a discrete compartment associated with the nucleolus. XIII Molecular Parasitology Meeting
Marine Biological Laboratory (Woods Hole, MA, United States)
2002 The catalytic component of Plasmodium telomerase is unusually large and localises in a discrete subnuclear compartment. Annual Meeting of the American Society for Tropical Medicine & Hygiene
(Denver, CO, United States)
2002 Telomerase of Plasmodium: a novel target for anti-malarial drugs?
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2001/09 Role of telomere ends in nuclear organisation of P. falciparum. XII Molecular Parasitology Meeting
Marine Biological Laboratory,. (Woods Hole, MA, United States)
2001/04 Subtelomeric regions in Plasmodium falciparum: evidence for their role in clustering of telomeres and telomere length regulation. Telomeres & Telomerase meeting
Cold Spring Harbor Laboratory (New York, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Characterisation of m6A-readers in trypanosomes.
Supervisor
 Masters in Biomedical Research (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2023/01/02 - Current Genomic requirements and enzymes mediating N6-Adenosine methylation of poly(A) tails in Trypanosoma brucei.
Supervisor
 PhD in Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/01 - Current Characterization of a novel methylation mechanism in Trypanosoma brucei.
Supervisor
 PhD in Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/07/06 - Current Trypanosome heterogeneity during in vivo infection.
Supervisor
 ITN Cell-2-Cell PhD program (PhD)
European Commission, Belgium
2022/08/28 - 2024/02/05 Deciphering how parasites trigger adipocyte lipolysis.
Supervisor
 Mestrado em Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/07 - 2023/09/05 How similar are freshly isolated Trypanosoma brucei parasites from the ones extensively used in the laboratory?
Supervisor
 Biomedical Research (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2022/12/20 Impact of adipose tissue colonization by Trypanosoma brucei during infection
Supervisor
 PhD in Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2022/06/29 Role of a novel RNA modification in African trypanosomes
Supervisor
 Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2022/05/30 Unraveling the role of Trypanosoma brucei proteins in the impairment of Plasmodium infection
Co-supervisor
 PhD in Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/09/08 - 2022/01/21 Adipocyte and T. brucei adaptations in a co-culture setting.
Supervisor of Ana Raquel Pereira
 Masters in Cell and Molecular Biology (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2021/04/12 Understanding how African trypanosomes impair a subsequent Plasmodium infection
Co-supervisor
 Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09 - 2020/06/24 Using computational biology to understand how parasites affect the host.
Supervisor
 Bioinformática e Biologia Computacional (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09 - 2019/11 How do parasites remodel their metabolism?
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/06 - 2019 Circadian rhythm in Trypanosoma brucei.
Supervisor
 Biochemistry (Master)
Freie Universität Berlin, Germany
2017/09 - 2018/11 Understanding the role of glycerol in parasite differentiation.
Supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/01 - 2018/09 Exploring the role of metabolic enzymes in parasite fat tropism.
Supervisor
 Medical and pharmaceutical biotechnology (Master)
IMC Fachhochschule Krems, Austria
2017/02 - 2017/12 Using proteomics to understand how parasites adapt to the host environment.
Supervisor
 Ciências de Engenharia - Engenharia Biomédica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/09 - 2017/10 Deciphering parasite persistence in adipose tissue.
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017 Trypanosoma brucei distribution in the male reproductive system.
Supervisor
 Mestrado Integrado em Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/09 - 2016/11 Post-transcriptional circadian gene expression regulation in Trypanosoma brucei.
Supervisor
 Bioinformática e Biologia Computacional (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/09 - 2016/11 Understanding the role of parasites epitranscriptome.
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/01 - 2016/07 Circadian rhythms in a Trypanosoma brucei infection: host, parasite or both?
Co-supervisor
 Biologia Básica e Aplicada (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/03 - 2016/04 Understanding chromatin dynamics during antigenic variation in Trypanosoma brucei
Supervisor
 Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014/09 - 2015/11 Role of long non-coding RNAs in parasite differentiation.
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/03 - 2015/03 Role of histone H1 in chromatin and gene expression in the African Trypanosome: broad skills, specific functions?
Supervisor
 Biomedical Sciences, Microbiology and Parasitology (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013/09 - 2014/11 N6-methyladenosine: a new modification in T. brucei.
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/08 - 2013/10 The Reciprocal Influence of Malaria and Sleeping Sickness Co-infections.
Co-supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/09 - 2012/11 Cell cycle expression and genome-wide distribution of histone H1 in Trypanosoma brucei.
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/05 - 2011/09 The role of chromatin remodeling enzymes in the antigenic variation of Trypanosoma brucei.
Supervisor
 Biologia Evolutiva e do Desenvolvimento (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/09/10 - 2024/09/14 The main motivation for Kinetoplastid Molecular Cell Biology Meeting is to provide a forum for everyone working on or interested in the Molecular Cell Biology of Trypanosomes and Leishmania and related model organisms. (2024/09/10 - 2024/09/14)
Conference (Co-organisor)
 Marine Biological Laboratory, United States
2023/09/24 - 2023/09/29 MSCA ITN Cell2Cell Summer School in Chromatin and infection Biology at the Single-Cell Level. (2023/09/24 - 2023/09/29)
Workshop (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2022/09/13 - 2022/09/17 The main motivation for Kinetoplastid Molecular Cell Biology Meeting is to provide a forum for everyone working on or interested in the Molecular Cell Biology of Trypanosomes and Leishmania and related model organisms. (2022/09/13 - 2022/09/17)
Conference (Co-organisor)
 Marine Biological Laboratory, United States
2018 - 2018 Chair of TwinnToInfect Spring School in Infection and Immunity (2018/03/19 - 2018/03/22) Instituto de Medicina Molecular, Portugal
2017 - 2018 Chair of Gordon Conference in Host-Parasite Interactions (2018/06/10 - 2018/06/15)
Congress (Member of the Organising Committee)
2016 - 2016 Vice-chair at Gordon Conference on the Biology of Host-Parasite interactions (2016/06/12 - 2016/06/17)
Congress (Co-organisor)
2013 - 2013 Co-organizer of EMBO Young Scientists’ Forum (2013/07/15 - 2013/07/16)
Symposium (Co-organisor)
 Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/11/09 - 2023/11/10 The art of supervising students - Skills for effective and empowering supervision Course.
Other
 The art of supervising students
Instituto de Medicina Molecular, Portugal
2022/03/27 - 2022/03/27 Design and discuss scientific solutions for problems associated with world feeding, Hackathon is organized by COLife in partnership with Ciência Viva, and with the support of the Oeiras Municipality and Portugal Bugs. The project entitled "Animal infections cause food shortage and poverty" was presented at the end of the challenge to a jury of talented researchers.
Other
 Hackathon: Future Food Challenge
Fundação Champalimaud, Portugal

Instituto de Medicina Molecular, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2021/05/12 - 2021/05/14 Self-leadership is the process by which a person becomes more comfortable with who they are and what they want, allowing them to fulfill their potential and build a strong foundation from which to take daily decisions – both professional and personal. Self-leadership enables better communication, satisfaction and more-balanced decisions. In the world of scientific research, both men and women can benefit from learning and practicing self-leadership to improve their professional and personal lives.
Workshop
 EMBO Self-Leadership Workshop – Online Course
European Molecular Biology Laboratory, Germany
2021/01/08 - 2021/01/09 The VIRT2UE Train the Trainer program addresses researchers and educators from different disciplines who want to become trainers in Research Integrity. The training takes a virtue-based approach and supports participants in reflecting on their understanding of, and own positions towards research integrity. In line with this, a strong focus is put on fostering reflecting on personal cases and experiences with the intention of building strong connections between theory and practice.
Workshop
 Research INtegrity Virt2UE
European Commission, Belgium
2014/10/06 - 2014/10/09 The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams.
Workshop
 EMBO Laboratory Management Course for Group Leaders
European Molecular Biology Laboratory, Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/01/30 Staphylococcus aureus intracellular lifestyle: phenotypical profiles and underlying molecular determinants.
(Thesis) Main arguer
 Inês Rodrigues Lopes (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/06/01 SRCR proteins as pattern recognition receptors: expanding the search for interactions with pathogens
(Thesis) Main arguer
 Marcos S. Cardoso (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/12/03 A novel role for EXP2 in invasion of Plasmodium sporozoites.
(Thesis) Main arguer
 João Mello Vieira (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/09/11 Unravelling the role of nucleoporins in the ploidy maintenance of trypanosomatid parasites.
(Thesis) Main arguer
 Akila Yagoubat (PhD)
Université de Montpellier, France
2019 Etude de potentiels facteurs de virulence et de pathoge´nicite´ chez les Trypanosomes Africains du parasite a` l’animal Loïc Rivière (Aggregation)
Université de Bordeaux, France
2019 Isolation and characterization of plant anti-trypanosomals for African trypanosomes.
(Thesis) Main arguer
 Aboagye Kwarteng Dofuor (PhD)
University of Ghana, Ghana
2019 Plasmodium exploitation of host methionine metabolism. Instituto Superior Técnico
(Thesis) Main arguer
 Catarina Pedro (Master)
2018 Identification and characterization of novel vaccine targets for the control of trypanosomiasis.
(Thesis) Main arguer
 Aitor Casas Sanchez (PhD)
Liverpool School of Tropical Medicine, United Kingdom
2017 Flow Cytometric Detection of Light Depolarization: A Novel Approach to Detect Antimalarial Drug Resistance in Resource-limited Endemic Region.
(Thesis) Main arguer
 Maria Rebelo (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 Trypanosoma brucei distribution in the male reproductive system.
(Thesis) Arguer
 Sílvia Teixeira da Silva (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 Characterization of P. falciparum histone methyltransferases: biological role and possible targets for new intervention strategies. , Paris, France.
(Thesis) Main arguer
 Shuai Ding (PhD)
Ecole Doctorale Complexité du Vivant, France
2016 Characterization of HRP4:¿an unusual Leishmania major HSP70-related protein.
(Thesis) Main arguer
 Sima Drimi (PhD)
Université Paris Diderot, France
2016 Nutrient Uptake and Metabolism in Plasmodium-infected hepatic cells.
Thesis Member
 Patrícia dos Santos Meireles (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 Iron Man(ipulation): unravelling the iron responsive genes’ network in malaria parasites.
(Thesis) Main arguer
 Miguel Dinis Santos (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 Insights on the function of MyTIL in AscII mediated neuronal reprogramming.
(Thesis) Main arguer
 Diogo Miguel Rosa Tomaz (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Mécanismes moléculares à l’origine de l’aneuploïdie mosaïque chez Leishmania: Caractérisation du complexe du pore nucléare chez les trypanosomatidés.
(Thesis) Main arguer
 Christelle Morelle (PhD)
Université de Montpellier, France
2015 Evaluation of Trypanosoma brucei asparagine synthetase A and ribose 5-phosphate isomerase B as potential drug targets.
(Thesis) Arguer
 Inês Soares Loureiro (PhD)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015 Role of Plasmodium translationally repressed gene products in malaria transmission.
Thesis Member
 Jorge Manuel dos Santos (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 Epigenetic mechanisms of effector ¿d T cell differentiation: Focus on histone modifications and microRNAs.
Thesis Member
 Nina Schmolka (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 Interaction of malaria parasites with host late endocytic and autophagic pathways is essential for Plasmodium liver stage development.
(Thesis) Arguer
 Carolina da Silva Macedo Matos (PhD)
Instituto Gulbenkian de Ciência, Portugal
2013 Generation and characterization of monoclonal antibodies against cell cycle and cytokinesis regulators in Trypanosoma brucei.
(Thesis) Main arguer
 Cristina de Almeida Costa (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013 Measuring chromosome-end fusions in fission yeast.
(Thesis) Arguer
 Hugo Ricardo Noronha de Almeida (PhD)
Instituto Gulbenkian de Ciência, Portugal
2012 Chromatin remodeling in Alzheimer's disease.
(Thesis) Main arguer
 Sueli Marques (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 Compositional and Functional Analysis of Polycomb Target Chromatin.
(Thesis) Main arguer
 José Ventura Antão (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 Epigenetic and cell cycle control of centromere inheritance.
(Thesis) Arguer
 Mariana Coelho Correia da Silva (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 Uncovering the role of host peroxisomal functions in Plasmodium liver stage infection.
(Thesis) Main arguer
 Joana de Teixeira Carrelha (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 O papel da trimetilação da histone H3 na transcrição.
(Thesis) Main arguer
 Ana Bernardino Raposo (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 Exploring the role of Jumonji/ARID1 family of proteins during embryonic stem cell differentiation and X-Chromosome Inactivation. Neuza Reis Matias (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Committee member

Activity description
Role 		Institution / Organization
2022/02/15 - 2022/02/16 Evaluation of research proposals in Wellcome Trust committee (UK).
Member
 Wellcome Trust, United Kingdom
2022/01/18 - 2022/01/20 Evaluation of research proposals in ANR committee (France).
Member
 Agence nationale de la recherche, France
2021/07/07 - 2021/07/08 Evaluation of research proposals in DFG committee (Germany).
Member
 Deutsche Forschungsgemeinschaft, Germany

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2011 - Current 3-hour lecture at Masters in Evolution and Development Biology, module on Animal Models in Biomedical Research. (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2023/10/23 - 2023/10/23 Masters in Biomedicine: Adipose tissue tropism in infectious diseases. Instituto de Medicina Molecular, Portugal
2023/04/19 - 2023/04/19 PhD program in Molecular Biosciences. (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/12/06 - 2022/12/06 Masters in Development Biology and Evolution: Adipose tissue tropism in infectious diseases. (Curso de mestrado (conclusão do curso de especialização)) Universidade de Lisboa Faculdade de Ciências, Portugal
2022/10/28 - 2022/10/28 Masters in Biomedicine: Adipose tissue tropism in infectious diseases. (Curso de mestrado (conclusão do curso de especialização)) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/09/23 - 2022/09/23 PhD Advanced Course in Molecular Biomarkers and technologies: RNA modifications and parasite virulence. Molecular Biomarkers and technologies (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/03/20 - 2022/03/20 LisbonBioMed PhD advanced course: How can parasites help obesity epidemics? (Curso de doutoramento (conclusão de unidades curriculares)) Instituto de Medicina Molecular, Portugal
2020/11/23 - 2020/11/23 Zoom lecture “Tissue Tropism in the mammalian host”. ITN Cell2Cell program. Instituto de Medicina Molecular, Portugal
2020/10/29 - 2020/10/29 Invited lecture "Is the adipose tissue an immune privileged site for trypanosomes?". Masters in Biomedical Research. (Mestrado) Instituto de Medicina Molecular, Portugal
2019/11/05 - 2019/11/05 RNA modifications in trypanosomes. Course of Animal Models in Biomedical Research (Bacharelato) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/10/31 - 2019/10/31 Parasite persistence in the fat. CAML Doctoral program. (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2015/02 - 2019/02 Organizer and lecturer of “Host and microbe interactions” 1-week course, as part of LisbonBioMed Doctoral Program (Curso de doutoramento (conclusão de unidades curriculares)) Instituto de Medicina Molecular, Portugal
2019/01/14 - 2019/01/16 Invited participation at the WACCBIP-ASCB Workshop. The West African Centre for Cell Biology of Infectious Pathogens. (Doktor (PhD)) University of Ghana, Ghana
2018/02/12 - 2018/02/16 Organizer and lecturer of “Parasite week” as part of Host-Pathogen Interaction Doctoral Program. (Curso de doutoramento (conclusão de unidades curriculares)) Instituto de Medicina Molecular, Portugal
2017/07/26 - 2017/07/29 Biology of Parasitism. How many different Trypanosoma brucei parasites are there in the host? Marine Biological Laboratory, United States
2014/10 - 2014/10 3 hour lecture for students of Masters in Evolution and Development Biology. “Circadian Rhythm & Infection” (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2014/05 - 2014/05 Sleeping sickness when a parasite makes the internal clock of the host run faster. GABBA PhD Program (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/11 - 2013/11 3 hour lecture for students of Masters in Evolution and Development Biology. “Mouse model to study circadian rhythm and understand how trypanosomes cause sleeping sickness” (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2013/02 - 2013/02 2 hour lecture for students of Masters in Biomedical Sciences. “What can the post-genomic era teach us about chromatin structure and gene regulation?” (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011/10 - 2011/10 Control of antigenic variation in African trypanosomes. IGC PhD program (Curso de doutoramento (conclusão de unidades curriculares)) Instituto Gulbenkian de Ciência, Portugal
2011/05 - 2011/05 African trypanosomes and epigenetics. Masters in Medical Parasitology (Curso de mestrado (conclusão do curso de especialização)) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011/03 - 2011/03 African trypanosomes and epigenetics. Masters in Emerging Infectious Diseases (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2011/03 - 2011/03 African trypanosomes and epigenetics. Masters in Evolution and Development Biology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Lisboa Faculdade de Ciências, Portugal
2011/01 - 2011/01 The role of chromatin in antigenic variation of African Trypanosomes. GABBA PhD program. (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001 - 2002 2-hour lecture at Masters in Parasitology. (Master) Université de Montpellier, France

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/10/04 "A doença do sono pode ter os dias contados?" Observador
2019/10/19 “Portugal ambiciona ter um novo prémio Nobel?" Opinion article for daily newspaper written jointly with Claudio Franco and Luisa Lopes. Publico
2018/10/16 Filipa Rijo-Ferreira (UTSW) shows that Trypanosoma brucei, the African sleeping sickness parasite, has circadian rhythms. YouTube
2017/07/05 Encontro Nacional da Ciência. Parasites have clocks. Encontro Ciência PT

Interview (tv / radio show)

Program Topic
2018/08/30 - Current SIC NOTÍCIAS Biological rhythms and EU proposal to end daylight time saving
2011/05/11 - 2011/05/11 Prós e Contras. Portugal: E depois do acordo?

Other jury / evaluation

Activity description Institution / Organization
2020 - 2020 Evaluation of Institute for Advanced Biosciences. Haut Conseil de l'évaluation de la recherche et de l'enseignement supérieur, France
2019/07/29 - 2019/08/14 Evaluation of candidates to participate in Middle Eastern Biology of Parasitism (MeBOP) course. Universität Bern, Switzerland
Distinctions

Award

2023 EMBO member
European Molecular Biology Laboratory, Germany
2020 Award of FCT CEEC Individual call salary contract
Fundação para a Ciência e a Tecnologia, Portugal
2017 ERC Consolidator grant
European Research Council, Belgium
2014 FCT investigator 2014
Fundação para a Ciência e a Tecnologia, Portugal
2010 Prémio Crioestaminal
2008 Ciencia 2008
Fundação para a Ciência e a Tecnologia, Portugal
2002 Award in recognition of scientific excellence in Molecular, Cellular and Immunoparasitology
ASTM International, United States
1997 Award for best student of bachelor degree in Biochemistry (1993-97)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal