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Ana Catarina Macedo Silva. Completed the Bachelor in Biology in 2016 at the Science Faculty (FCUP) and Master in Oncology in 2018 at the School of Medicine and Biomedical Science (ICBAS) of University of Porto (UP). Since April 2023, held a European doctoral degree in Translational Medicine, conferred with distinction "cum laude" by the University Degli Study della Campania "Luigi Vanvitelli", Naples, Italy . Currently, is a PostDoctoral fellow at Cancer Biology and Epigenetics group, at Portuguese Institute of Porto, Portugal. Cancer epigenetics, cell biology and radiobiology is the main topic of investigation with a substantial list of publications in international peer-reviewed journals, as original articles and review papers. Histone modifications and prostate cancer radioresistance is the ongoing research field at the Cancer Biology & Epigenetics Group of Research Center of Portuguese Oncology Institute of Porto (CI-IPOP).
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Identification

Personal identification

Full name
Ana Catarina Macedo Silva

Citation names

  • Macedo-Silva, Catarina

Author identifiers

Ciência ID
431B-EBE0-4F6D
ORCID iD
0000-0002-7434-8398

Email addresses

  • i13061@ipoporto.min-saude.pt (Professional)
  • anacatarina.macedodasilva@unicampania.it (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Natural sciences - Biological Sciences - Biology
  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Portuguese (Mother tongue)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Elementary (A2) Upper intermediate (B2) Beginner (A1)
Italian Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/11/01 - 2023/04/20
Concluded
 Translational Medicine (Dottorato di Ricerca)
Major in Oncology
Università degli Studi della Campania Luigi Vanvitelli, Italy
"Advances in Epigenetic targeting for Prostate Adenocarcinoma: Dissecting the interplay between epigenetic chromatin remodelers and RadioTherapy resistance (EpiPaRTy)" (THESIS/DISSERTATION)
2016/09/01 - 2018/11/01
Concluded
 Oncologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Esophageal cancer therapy response: role of hypoxia in epigenetic mechanism regulation" (THESIS/DISSERTATION)
 18
2013/09/01 - 2016/07/01
Concluded
 Biologia (Licenciatura)
Major in Ciências básicas
Universidade do Porto Faculdade de Ciências, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2023/04/05 - 2024/04/05 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2018/10/01 - 2019/10/31 Research Trainee (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/10/01 - 2023/07/31 Invited Assistant (Polytechnic Teacher) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
Instituto Politécnico do Porto, Portugal
Projects

Grant

Designation Funders
2018/10/01 - 2019/10/31 SIRNAC “Novel Therapies against Metastatic Colorectal cancer”
NORTE-01-0247-feder-033399
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2017/09/01 - 2018/11/01 EARLY-STAGE CANCER TREATMENT IN THE CONTEXT OF MOLECULAR IMAGING (ESTIMA)
NORTE-01-0145-FEDER-000027
Master student without fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/04 - 2024/04 MindGAP: Bridging the GAP between mind, brain and body: Exossome role and monitoring
Horizon 2020-FETOPEN-2018-2020
Horizon 2020-FETOPEN-2018-2020
Research Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Horizon 2020
2019/10/01 - 2023/02/28 Advances in Epigenetic targeting for Prostate Adenocarcinoma: Dissecting the interplay between epigenetic chromatin remodelers and RadioTherapy resistance (EpiPaRTy)
2019-UNA2CLE-0170010
PhD Student Fellow
Università degli Studi della Campania Luigi Vanvitelli
2019/01/01 - 2019/12/31 Centro de Investigação do Instituto Português de Oncologia do Porto
UID/DTP/00776/2019
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2019/10/31 SIRNAC- Novel Therapies Against Metastatic Colorectal Cancer
NORTE-01-0247-FEDER-033399
Research Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Ongoing

Other

Designation Funders
2021/04/01 - Current IMAGE: ¿Individualized Gastric Adenocarcinoma ¿Early Diagnosis and Improved Patients¿ Survival: From Liquid Biopsies to a Comprehensive Management Approach
NORTE-01-0145-FEDER-000050
Researcher
Norte2020 (Portugal 2020)
2022/09/01 - 2023/12/31 The practicability of subtyping prostate cancers by IHC analysis (PROSTYPING)
PI 27-CI-IPOP-FB-CBEG
Lab tutoring
2017/09/01 - 2018/11/01 Interplay between Warburg Effect and epigenetic mechanism in Kidney Cancer
CI-IPOP-92-2018-MCTKidCan
Other
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação
Concluded
Outputs

Publications

Conference poster
  1. Macedo-Silva, Catarina; Angela Albuquerque-Castro; Lencart, Joana; Carneiro, Isa; Nuno Tiago Tavares; Barros-Silva, Daniela; João Lobo; et al. "Epigenetic reprogramming as Hallmark of prostate cancer radiobiology". Paper presented in Young Researchers Day IPO Porto, 2023.
  2. Macedo-Silva, Catarina; Vera Miranda-Gonçalves; Nuno Tiago Tavares; Barros-Silva, Daniela; Angela Albuquerque-Castro; Lencart, Joana; Carneiro, Isa; et al. "Epigenetic modulation of p53 by GSK-J4 attenuates prostate cancer radioresistance". Paper presented in ImmunoRad, 2023.
  3. Estêvão, Diogo; da Cruz-Ribeiro, Miguel; Macedo-Silva, Catarina; Jerónimo, Carmen; Olga Sousa; De Wever, Olivier; Maria José Oliveira; Cruz, Tânia. Corresponding author: da Cruz-Ribeiro, Miguel. "Dissecting the Radiotherapy-mediated changes in Rectal Cancer Immune Profile". Paper presented in XLVIII SPI Annual Meeting, 2023.
  4. Macedo-Silva, Catarina; Constâncio, Vera; Vera Miranda-Gonçalves; Leite-Silva, Pedro; Salta, Sofia; João Lobo; Guimaraes, Rita; et al. "DNA methylation biomarkers to residual disease detection in esophageal cancer upon neoadjuvant chemoradiation". Paper presented in 5TH ASPIC International congress, 2022.
  5. Vera Miranda-Gonçalves; Lameirinhas, Ana; Macedo-Silva, Catarina; João Lobo; Paula C.Dias; Verónica Ferreira; Henrique, Rui; Jerónimo, Carmen. "Lactate-Sirtuin 6 axis mediating a metabolic reprogramming in renal cell carcinoma". Paper presented in 5TH ASPIC International congress, 2022.
  6. Macedo-Silva, Catarina; Oriana Ribeiro; Nuno Tiago Tavares; Vera Miranda-Gonçalves; Joana Lencart; Sofia Silva; Benedetti, Rosaria; et al. "Epigenetically-induced TP53 in radioresistant prostate cancer model: A new radiosensitizing strategy.". Paper presented in EACR 2022 Congress – Innovative Cancer Science: Translating Biology to Medicine., 2022.
  7. Macedo-Silva, Catarina; Oriana Ribeiro; Margareta P. Correia; Lencart, Joana; Sofia Silva; dos SANTOS, JOÃO; Benedetti, Rosaria; Altucci, Lucia; Jerónimo, Carmen. "Tackling the interplay between epigenetic and DNA damage repair in radioresistant PCa.". Paper presented in II ASPIC-ASEICA International Meeting, Current trends of precision medicine in cancer, 2021.
  8. Lima, Ana Rita; Carvalho, Márcia; Aveiro, Susana S.; Melo, Tânia; Domingues, Maria Rosário; Macedo-Silva, Catarina; Coimbra, Nuno; et al. "Integration of metabolomics and lipidomics for prostate cancer tissue fingerprinting". Paper presented in Metabolomics 2021 Online, 2021.
  9. Macedo-Silva, Catarina; Oriana Ribeiro; Lencart, Joana; Sofia Silva ; João Santos; Benedetti, Rosaria; Altucci, Lucia; Jerónimo, Carmen. "Prostate cancer radioresistance mediated by chromatin openness: the critical role of histone post-translational modifications". Paper presented in 27th Porto Cancer Meeting, Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  10. Vera Miranda-Gonçalves; Lameirinhas, Ana; Macedo-Silva, Catarina; Henrique, Rui M.F.; Jerónimo, Carmen. "Lactate in renal cell carcinoma progression: modulation of epigenetic landscape.". Paper presented in Epigenetics & Chromatin – Cold Spring Harbor Laboratory, 2018.
  11. Macedo-Silva, Catarina; Vera Miranda-Gonçalves; Lencart, Joana; Sofia silva; Lameirinhas, Ana; Henrique, Rui M.F.; Bravo, Isabel; Jerónimo, Carmen. "Esophageal cancer therapy response: Role of hypoxia in epigenetic mechanism regulation.". Paper presented in 3rd ASPIC International Congress, Radiobiology/ Radiation Oncology, Gulbenkian Foundation, 2018.
  12. Lameirinhas, Ana; Vera Miranda-Gonçalves; Macedo-Silva, Catarina; Henrique, Rui; Jerónimo, Carmen. "Lactate modulates epigenetic mechanisms contributing to kidney cancer progression". Paper presented in 3rd ASPIC International Congress, Cancer and Metabolism, Gulbenkian Foundation, 2018.
Journal article
  1. Macedo-Silva C; Miranda-Gonçalves V; Tavares NT; Barros-Silva D; Lencart J; Lobo J; Oliveira Â; et al. "Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling.". Signal transduction and targeted therapy (2023): https://europepmc.org/articles/PMC10577134.
    10.1038/s41392-023-01639-6
  2. Tânia Lima; Catarina Macedo-Silva; Diana Felizardo; João Fraga; Isa Carneiro; Carmen Jerónimo; Rui Henrique; Margarida Fardilha; Rui Vitorino. "Gal-3 Protein Expression and Localization in Prostate Tumours". Current Oncology (2023): https://doi.org/10.3390/curroncol30030206.
    10.3390/curroncol30030206
  3. Macedo-Silva C; Constâncio V; Vera Miranda-Gonçalves; Pedro Leite-Silva; Salta S; Lobo J; Guimarães R; et al. "DNA methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation.". Cancer medicine (2023): https://europepmc.org/articles/PMC10134363.
    10.1002/cam4.5623
  4. Angela Carvalho; Guimarães-Teixeira C; Constâncio V; Fernandes M; Macedo-Silva C; Henrique R; Monteiro FJ; Jerónimo C. "One sample fits all: a microfluidic-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer.". Biomaterials science (2022): https://doi.org/10.1039/d2bm00044j.
    10.1039/d2bm00044j
  5. Lima, Ana Rita; Carvalho, Márcia; Aveiro, Susana S.; Melo, Tânia; Domingues, M. Rosário; Macedo-Silva, Catarina; Coimbra, Nuno; et al. "Comprehensive Metabolomics and Lipidomics Profiling of Prostate Cancer Tissue Reveals Metabolic Dysregulations Associated with Disease Development". Journal of Proteome Research (2021): http://dx.doi.org/10.1021/acs.jproteome.1c00754.
    10.1021/acs.jproteome.1c00754
  6. Macedo-Silva, Catarina; Benedetti, Rosaria; Ciardiello, Fortunato; Cappabianca, Salvatore; Jerónimo, Carmen; Altucci, Lucia. "Epigenetic mechanisms underlying prostate cancer radioresistance". Clinical Epigenetics 13 1 (2021): http://dx.doi.org/10.1186/s13148-021-01111-8.
    10.1186/s13148-021-01111-8
  7. Garrido-Cano, Iris; Adam-Artigues, Anna; Lameirinhas, Ana; Pattanayak, Birlipta; Tormo, Eduardo; Miranda-Gonçalves, Vera Mónica; Macedo-Silva, Catarina; et al. "miR-503-5p induces doxorubicin resistance in triple-negative breast cancer.". Journal of Clinical Oncology 39 15_suppl (2021): 1083-1083. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1083.
    10.1200/jco.2021.39.15_suppl.1083
  8. Catarina Macedo-Silva; Vera Miranda-Gonçalves; Ana Lameirinhas; Joana Lencart; Alexandre Pereira; João Lobo; Rita Guimarães; et al. "JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma". Cell Death & Disease (2020): https://doi.org/10.1038/s41419-020-03279-y.
    10.1038/s41419-020-03279-y
  9. Salta, Sofia; Macedo-Silva, Catarina; Miranda-Gonçalves, Vera; Lopes, Nair; Gigliano, Davide; Guimarães, Rita; Farinha, Mónica; et al. "A DNA methylation-based test for esophageal cancer detection". Biomarker Research 8 1 (2020): http://dx.doi.org/10.1186/s40364-020-00248-7.
    10.1186/s40364-020-00248-7
  10. Vera Miranda-Gonçalves; Ana Lameirinhas; Catarina Macedo-Silva; João Lobo; Paula C.Dias; Veronica Ferreira; Rui Henrique; Carmen Jerónimo. "Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation". Cells (2020): https://doi.org/10.3390/cells9041053.
    Open access • Accepted
  11. Vera Miranda-Gonçalves; Ana Lameirinhas; Catarina Macedo-Silva; João Lobo; Paula C. Dias; Verónica Ferreira; Rui Henrique; Carmen Jerónimo. "Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation". Cells 9 4 (2020): 1053-1053. https://doi.org/10.3390/cells9041053.
    10.3390/cells9041053
  12. Catarina Macedo Silva; Vera Miranda-Gonçalves; Rui Henrique; Carmen Jeronimo; Isabel Bravo. "The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance". Genes (2019): https://www.mdpi.com/2073-4425/10/11/927.
    10.3390/genes10110927
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/11/10 Chicken Chorioallantoic membrane (CAM) assay 24th Editions of Craiova International Medical Students’Conference
(Craiova, Romania)
2021/10/14 SLC3A2 rs2070870 C allele associated with worse overall survival incolorectal cancer patients. II ASPIC-ASEICA International Meeting, Current trends of precision medicine in cancer
i3s (Porto, Portugal)
2019/10/17 Epigenetic-Metabolic interplay in renal cell carcinoma: role of lactate on sirtuin s modulation ISCaM, 6th Annual Meeting: Cancer Metabolic Rewiring
ICVS (Braga, Portugal)
2019/10/10 Metabolic reprogramming and epigenetic landscape: an interplay to renal cell carcinoma aggressiveness. 26th Meeting of the EAU Section of Urological Research (ESUR)
IPO Porto, Research Center (Porto, Portugal)
2019/02/13 Role of JmjC-KDMs in HIF-1alpha-dependent modulation: Effect on esophageal squamous cell carcinoma resistance IJUP
Universidade do Porto (Porto, Portugal)
2019/02/12 Impact of lactate exposure in renal cell carcinoma aggressiveness: Role of sirtuin’s modulation IJUP
Universidade do Porto (Porto, Portugal)
2018/05/15 Esophageal cancer therapy response: Role of hypoxia in epigenetic mechanism regulation 2nd Symposium of Master Oncology: Treatment and Drug Resistance
IPO Porto (Porto, Portugal)
2018/05/15 Interplay between Warburg Effect and epigenetic mechanism in Kidney Cancer 2nd Symposium of Master Oncology: Cancer Biology
IPO Porto (Porto, Portugal)

Association member

Society Organization name Role
2018/09/01 - Current ASPIC/EACR PhD Student member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/10/21 - 2019/11/01 Técnicas básicas de cultura celular Curso básico de cultura de células (Outros) EPOP Escola Portuguesa de Oncologia do Porto, Portugal
Distinctions

Award

2023 Best Poster Presentation
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2020 Prémio Princípe da Beira Ciências Biomédicas
Fundação D.Manuel II, Portugal

Other distinction

2019 Introduction to NGS data analysis: from raw data to intelligible output (ECOST- TRAINING_SCHOOL-CM1406-130319-103474)