ANA LÚCIA MARQUES BATISTA DE CARVALHO (4419-A4AF-3D7C)

Curriculum Vitae

ANA LÚCIA MARQUES BATISTA DE CARVALHO

Ana Lúcia Marques Batista de Carvalho has a PhD in Biosciences (2017) by University of Coimbra and her Master in Biochemistry in 2010 by University of Coimbra with her Master Thesis being developed at Universita degli Studi di Roma La Sapienza Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli. Presently she is a Junior Researcher at Unidade de I&D Química-Física Molecular of the University of Coimbra within the CEEC 2017 call. She has published 39 articles in journals with peer review with a total of 526 citations and H-index of 14 (search done by author Batista de Carvalho, A.L.M.). Supervised or co-supervised several MSc and BSc students. She is presently co-supervisor of 3 PhD student. She participated in 4 projects and is presently a member of two funded R&D Project NeedfoRSpeed (2022.03336.PTDC) and BetterBone (2022.04286.PTDC). She is an Associated member of the Royal Society of Chemistry (RSC), belongs to the Clinical Infrared and Raman Spectroscopy for Medical Diagnosis (CLIRSPEC) as well as to the Portuguese Society of Biochemistry (SPB). She has expertise in applying vibrational spectroscopy (FTIR (either benchtop or Syncrothron radiation), Raman and with neutrons) to the study of biological samples such as human cells and tissues. She is currently conducting research on the identification, using vibrational spectroscopy, of early liver rejection biomarkers in liver biopsies demonstrating scientific independence with 2 papers published as senior author and 6 as corresponding author . She is also enrolled in the design of Pt/Pd-based anticancer agents.

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Identification

Personal identification

Full name: ANA LÚCIA MARQUES BATISTA DE CARVALHO

Citation names

Ana L. M. Batista de Carvalho
Batista de Carvalho, A.L.M.
A.L.M., Batista de Carvalho

Author identifiers

Ciência ID: 4419-A4AF-3D7C
ORCID iD: 0000-0003-1280-3321
Google Scholar ID: https://scholar.google.com/citations?hl=en&user=_WaX7AEAAAAJ&view_op=list_works&sortby=pubdate
Researcher Id: A-2929-2014
Scopus Author Id: 55355733500

Websites

https://qfm.uc.pt/index.html/language/en/anabatistacarvalho/ (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Health Sciences
Exact Sciences - Chemical Sciences - Physical Chemistry

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Italian	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)
French	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2023/11 - 2024/04 Concluded	Preparar para Docência em Ambientes Digitais e a Distância (PDADD) (Outros) Universidade de Coimbra, Portugal
2024/03 - 2024/03 Concluded	Conferência Final do Projeto GendER@UC EEA Grants (Outros) Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2023/03/30 - 2023/03/30 Concluded	Workshop sobre Género e Liderança para a Excelência na Investigação (Outros) Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/07/19 - 2022/07/19 Concluded	Curso de Boas Práticas na Orientação Doutoral (Outros) Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/03/15 - 2022/03/15 Concluded	Gestão de Dados de Investigação (Outros) Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/02/22 - 2022/02/22 Concluded	Supervisão Doutoral: Abordagens e Práticas (Outros) Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/02/07 - 2022/02/07 Concluded	TIMB3 Workshop Imaging in Biosciences (Outros) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/11/18 - 2021/11/19 Concluded	Joint FEBS/SPB/UMinho Symposium on Evidence Based Teaching in Your Biomolecular Classroom: Catalysing Student Engagement (Outros) Universidade do Minho, Portugal
2021/03/23 - 2021/03/25 Concluded	Advanced Infrared Microspectroscopy Analysis Training - QUASAR software (Outros) Diamond Light Source Ltd, United Kingdom
2018/10/10 - 2018/10/12 Concluded	Interdisciplinary Summer School on Clinical Biophotonics (Outros) Raman4Clinics, Germany
2017/03/19 - 2017/03/21 Concluded	X-Ray Absorption Spectroscopy Workshop (Outros) Diamond Light Source, United Kingdom
2017 Concluded	Doutoramento em Biociências especialização em Bioquímica (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Cisplatin-like Compounds as Potential Chemotherapeutics: from the Bench to the Cell." (THESIS/DISSERTATION)	Aprovado com distinção e louvor por unanimidade
2016 - 2016 Concluded	Interdisciplinary Summer School on Clinical Biophotonics (Outros) Raman4Clinics, Germany
2015 - 2015 Concluded	SALSA Summer University 2015 - Sensitivity & Selectivity (Outros) School of Analytical Sciences Adlershof , Germany
2014 - 2014 Concluded	Multivariate IR Microspectroscopy Analysis Training Course – Unscrambler X (Outros) Diamond Light Source, United Kingdom
2014 - 2014 Concluded	Hands-on course on Microscopy Analysis Imaging at the Center for Neuroscien (Outros) Centro de Neurociências Coimbra, Portugal
2013 - 2013 Concluded	Ciência em Animais de Laboratório - Categoria B (Outros) Universidade do Porto, Portugal
2013 - 2013 Concluded	Segurança e Saúde Ocupacional em Laboratórios (Outros) Biocant Park - Formações Microbiologia, Portugal
2011 - 2011 Concluded	Biostatistics (Outros) Centro de Neurociências Coimbra, Portugal
2010 Concluded	2º Ciclo em Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Universita degli Studi di Roma La Sapienza Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli, Italy "Cytotoxic Effect Induced by Combination of Polyamines Metabolites and Endocannabinoid, Anandamide, on Human Cancer Cell: A New Anticancer Strategy" (THESIS/DISSERTATION)	17
2005 - 2008 Concluded	1º Ciclo em Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciencias da Vida, Portugal "Caracterização Conformacional e Avaliação de Citotoxicidade de Complexos de Pt(II) e Pd(II) com Diaminas" (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2019/05/16 - Current	Contracted Researcher (Research)	Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal

2017/12/19 - 2018/12/18	Postdoc (Research)	Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal

2010/11 - 2017/08	Researcher (Research)	Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal

2009/10 - 2010/06	Research Trainee (Research)	Università degli Studi di Roma La Sapienza, Italy

2008/02 - 2008/07	Research Trainee (Research)	Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal

Projects

Grant

	Designation	Funders
2025/01 - 2026/06	LookInUterus Vibrational spectroscopy of hysteroscopic fluid and endometrial polyps for prediction of malignancy and treatment options 2023.13453.PEX Principal investigator Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2015/07 - 2020/12	BioImpact - Biochemical Impact of Ptatinum and Palladium Anticancer Agents PTDC/QEQ-MED/1890/2014 Researcher	Fundacao para a Ciencia e a Tecnologia Concluded
2016 - 2017	ReNATURE - Valorisation of the NAtural Endogenous Resources of the Central Region of Portugal Centro-01-0145-FEDER-000007 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Actividade Anticancerígena de Novos Complexos de Pd(II) com Poliaminas - Um Estudo Multidisciplinar PTDC/QUI/66701/2006 PhD Student Fellow Unidade I&D Química-Físicia Molecular, Portugal	Fundacao para a Ciencia e a Tecnologia Concluded

Other

	Designation	Funders
2023/02/20 - Current	BetterBone - Metabolite-activated 3D stem cell differentiation into bone 2022.04286.PTDC Investigator	Fundação para a Ciência e a Tecnologia Ongoing
2023/01/01 - Current	NeedfoRSpeed - A compressive spectrometer for melanoma diagnosis 2022.03336.PTDC Investigator	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/18 - 2022/10/18	VibsONCancer - Molecular Cancer Diagnostics by Vibrational Spectroscopy POCI-01-0145-FEDER-0016786 Centro-01-0145-FEDER-029956 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2018/06/22 - 2021/06/21	Molecular Cancer Diagnostics by Vibrational Spectroscopy PTDC/QUI-QAN/29956/2017 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Batista De Carvalho, A.L.M.; Fiuza, S.M.; Tomkinson, J.; Batista De Carvalho, L.A.E.; Marques, M.P.M.. Pt(II) complexes with linear diamines. I-Vibrational study of Pt-diaminopropane. 2013. 10.3233/978-1-61499-184-7-147
Book chapter	Batista de Carvalho, A.L.M.; Fiuza, S.M.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) Complexes with Linear Diamines. I - Vibrational Study of Pt-Diaminopropane". In Spectroscopy of Biological Molecules, 147-156. Lansdale: IOS Press, 2013. Published
Conference abstract	Vojtek, Martin; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.; Mota-Filipe, Helder; Ferreira, Isabel M. P. L. V. O.; Diniz, Carmen. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022. 10.3390/ecmc2022-13469
Conference paper	Martin Vojtek; Maria P. M. Marques; Ana L. M. Batista de Carvalho; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022. 10.3390/ECMC2022-13469 Marques, M.P.M.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Hatter, L.; Batista de Carvalho, L.A.E.. "Intracellular Water - A Secondary Target in Chemotherapy - Impact of Pt/Pd Anticancer Drugs in Breast Cancer Cells Probed by Neutron Techniques". Paper presented in 7th International Workshop on Electron-volt Neutron Spectroscopy, 2017. Oliveira, L.C.; Batista de Carvalho, A.L.M.; Marques, M.P.M.; Fonseca, A.P.. "Parameterising PDK1-Induced Perturbations on the Dose-Response Profile of Human Glioblastoma". 2016. Batista de Carvalho, A.L.M.; Tempera, G.; Viceconte, N.; Saccoccio, S.; Bidollari, E.; Nalli, M.; Morera, E.; et al. "Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: A new anticancer strategy". Paper presented in The 16th International Charles Heidelberger Symposium on Cancer Research, 2010. Published • 10.1186/1753-6561-4-S2-P31
Conference poster	Laginha, Raquel C.; Silva, J.D.; Cinque, G.; Batista de Carvalho, L. A. E.; Ana L. M. Batista de Carvalho. Corresponding author: Ana L. M. Batista de Carvalho. "Uncovering New Chemotherapeutic Methods for Osteosarcoma with Vibrational Microspectroscopy". Paper presented in 20th European Conference on the Spectroscopy of Biological Molecules (ECSBM20), 2024. Martins, Clara B.; Vojtek, M.; Diniz, C.; Batista de Carvalho, L. A. E.; Marques, MPM; Ana L. M. Batista de Carvalho. ""Metabolic effect of Pd(II) Trinuclear Chelate with spermidine on TNBC-Sensitive and -Resistant to cisplatin"". Paper presented in HIRES 2023 Synergies in High Resolution Spectroscopy, 2023. Vojtek, M. (5F15-7817-94DC); Marques, MPM; Ana L. M. Batista de Carvalho; Ferreira, I.M.P.L.V.O.; Mota-Filipe, H.; Diniz, C.. "Palladium-spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-independent Cell Death in Triple-negative Breast Cancer Cells". Paper presented in 8th International Electronic Conference on Medicinal Chemistry (ECMC 2022), 2023. Carneiro, Tatiana J.; Vojtek, M. (5F15-7817-94DC); Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Marques, MPM; Diniz, C.; Gil, A.M.. "O Perfil Metabólico de Tumor e Cérebro de Ratinhos Xenógrafos de Cancro da Mama Triplo-Negativo Revela Efeito Promissor do Complexo Pd2Espermina Relativamente a Cisplatina". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023. Carneiro, Tatiana J.; Vojtek, M. (5F15-7817-94DC); Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Marques, MPM; Diniz, C.; Gil, A.M.. "NMR metabolomics unveils a beneficial metabolic response of mice brain to Palladium(II)-Spermine, a possible alternative to cisplatin for cancer treatment". Paper presented in The 19th European Magnetic Resonance Congress (EUROMAR 2023), 2023. Martins, Clara B.; Vojtek, M. (5F15-7817-94DC); Diniz, C.; Batista de Carvalho, Luis Alberto Esteves; Marques, MPM; Ana L. M. Batista de Carvalho. "Metabolic Profiling of Breast Cancer Cell Lines by Vibrational Microspectroscopy". Paper presented in 47th FEBS Conference, 2023. Martins, Clara B.; Ana L. M. Batista de Carvalho; A. P. Mamede; Silva, J. D.; Santos, I.P.; Figueiredo, P. ; Sarter, M.; et al. "Unraveling the Healthy-to-Cancer Transition: Water Dynamics as a Key Biomarker". Paper presented in 9º Encontro Nacional de Utilizadores de Radiação de Sincrotrão, 2023. Martins, Clara B.; Ana L. M. Batista de Carvalho; A. P. Mamede; Silva, J.D.; Santos, I.P.; Figueiredo, P.; Sarter, M.; et al. "Unraveling the Healthy-to-Cancer Transition: Water Dynamics as a Key Biomarker". Paper presented in ILL Soft Matter Summer School, 2023. A.L.M., Batista de Carvalho. "Chemotherapeutic response to cisplatin and Pd2-Spm drugs in PC-3 cell line by FTIR microspectroscopy". Paper presented in VIII Encontro Nacional de Estudantes de Química (VIII ENEQUI), 2022. A.L.M., Batista de Carvalho. "Spectral Histopathology: A Brighter Future for Breast Cancer Diagnosis". Paper presented in 12th International Conference on Clinical Spectroscopy (SPEC 2022), 2022. A.L.M., Batista de Carvalho. "Who's who? Discrimination of Breast Cell Lines by Raman Microspectroscopy". Paper presented in 27th International Conference on Raman Spectroscopy (ICORS), 2022. A.L.M., Batista de Carvalho. "Who's who? Discrimination of Breast Cell Lines by FTIR Microspectroscopy". Paper presented in 19th European Conference on Spectroscopy of Biological Molecules, ECSBM 2022, 2022. Pires, C.L.; Praça, C.; Martins, P.A.T.; Ana L. M. Batista de Carvalho; Ferreira, L.; Marques, M.P.M.. "Re-use of Caco-2 Monolayers in Permeability Assays - Validation Regarding Cell Monolayer Integrity". Paper presented in 7th International Iberian Biophysics Congress, 2021. A. P. Mamede; Santos, I.P.; Figueiredo, P. ; Ana L. M. Batista de Carvalho; Marques, M.P.M.; Batista de Carvalho, L. A. E.. "Spectral Histopathology - A Rising Field for Breast Cancer Diagnosis". Paper presented in ICAVS11 Conference, 2021. Ana L. M. Batista de Carvalho. "Spectral Histopathology - A Rising Field for Breast Cancer Diagnosis". Paper presented in 11th International Conference on Advanced Vibrational Spectroscopy (ICAVS 11), 2021. Carneiro, T.; Araújo, A.R.; Diniz, C.; Batista de Carvalho, A.L.M.; Marques, M.P.M.; Gil, A.M.. "NMR Metabolomics to Assess Nephrotoxicity Induced by Cisplatin and Pd2(spermine) in a Mouse Model". Paper presented in Jornadas CICECO 2019 “Where Science Meets Society”, 2019. Batista de Carvalho, L.A.E.; Batista de Carvalho, A.L.M.; Parker, S.F.; Marques, M.P.M.. "Complete Vibrational Study of a Novel Pt(II)-based Anticancer Drug, by Combined FTIR, Raman and INS Techniques". Paper presented in SPEC Conference (SPEC 2018) – Shedding New Light on Disease, 2018. Mamede, A.P.; Matos, C.S.; Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Pt(II) and Pd(II) Polyamine Complexes in the Spotlight of Metastatic Prostate Cancer Treatment". Paper presented in 43rd FEBS Congress – Biochemistry Forever, 2018. Martins, A.S.; Batista de Carvalho, A.L.M.; Lamego, I.; Marques, M.P.M.; Gil, A.. "Cytotoxic Impact of Platinum and Palladium-based Drugs on MG-63 Cells". Paper presented in Jornadas CICECO 2018 “Living Science Together”, 2018. Dias, J.R.; Ana L. M. Batista de Carvalho; Barroca, M.J.; Moreira da Silva, A.. "Antioxidant and cytotoxic effects of Salicornia ramosissima extracts in cancer cells". Paper presented in 1st International Meeting on Innovation & Development in the Food Sector, 2018. Moreira da Silva, A.; Santos, L.; Simões, L.; Batista de Carvalho, A.L.M.; Barroca, M.J.. "Cytotoxic and Antioxidant Activities of White Portuguese Crowberry Extracts". Paper presented in 2nd Conference Food Bioactives & Health, 2018. Ana L. M. Batista de Carvalho; Doherty, J.; Gardner, P.; Frogley, M.; Cinque, G.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Probing Drug-DNA Interplay by THz Spectroscopy". Paper presented in 9th International Workshop on Infrared Microscopy and Spectroscopy with Accelerator Based Sources (WIRMS), 2017. Batista de Carvalho, A.L.M.; Pilling, M.; Gardner, P.; Doherty, J.; Cinque, G.; Wehbe, K.; Kelly, C.; Batista de Carvalho, L.A.E; Marques, M.P.M.. "Impact of Quercetin on Chemotherapy Response in Metastatic Human Breast Cancer – A Vibrational Microspectroscopy Study". Paper presented in 42nd FEBS Congress – from Molecules to Cells and Back, 2017. Marques, M.P.M.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Hatter, L.; Batista de Carvalho, L.A.E.. "Anticancer Drug Impact on Intracellular Water". Paper presented in Meeting of the COST-BM1401 Working Group – Raman-based Applications for Clinical Diagnostics (Raman4Clinics), 2017. Ruano, C.; Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Otero, J.C.; Marques, M.P.M.. "Effect of Antioxidants on Breast Cancer Cells Probed by Raman Microspectroscopy". Paper presented in XXXVI Reunião Bienal da Real Sociedade Espanhola de Química, 2017. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Chemoprevention Strategies Against Melanoma - New Perspectives using Raman Microspectroscopy". Paper presented in RAMAN4CLINICS – SUMMER SCHOOL Clinical Biophotonics, 2016. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Potential Chemopreventive Compounds Against Melanoma - New perspective using Raman Spectroscopy". Paper presented in XXV Reunión Nacional de Espectroscopia (XXV RNE) - IX Congreso Ibérico de Espectroscopia (IX CIE), 2016. Batista de Carvalho, A.L.M.; Pilling, M.; Gardner, P.; Doherty, J.; Cinque, G.; Wehbe, K.; Kelley, C.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Impact of Dietary Antioxidants on Chemotherapy Response Probed by Vibrational Microspectroscopy in Metastatic Human Breast Cancer". Paper presented in Faraday Discussions, 2016. 10.1039/C6FD90024K Silva, A.; Batista de Carvalho, A.L.M.; Maia, C.; Ferreira, R.; Marques, M.P.M.; Batista de Carvalho, L.A.E.; Patício, M.; Roda, J.. "Prevalence of Subclinical Deficit of Vitamin K, Detected by Spectroscopy of Micro-Raman". Paper presented in RAMAN4CLINICS – SUMMER SCHOOL Clinical Biophotonics, 2016. Batista de Carvalho, A.L.M.; Pilling, M.; Gardner, P.; Doherty, J.; Cinque, G.; Wehbe, K.; Kelley, C.; Marques, M.P.M.; Batista de Carvalho, L.A.E.. "Chemotherapy Response of Quercetin Combined with a Cisplatin-like Agent Probed by Microvibrational Spectroscopy in Triple Negative Breast Cancer". Paper presented in IX CIE (IX Congresso Ibérico de Espectroscopia/XXV Reunión Española de Espectroscopía), 2016. Marques, M.P.M.; Ana L. M. Batista de Carvalho; Garcia-Sakai, V.; Hatter, L.; Batista de Carvalho, L.A.E.. "Intracellular Water - an Overlooked Target of Drug Activity? Cisplatin´s Impact in Breast Cancer Cells Probed by Neutron Techniques". Paper presented in Workshop 50 Years of Neutron Backscattering Spectroscopy, 2016. Marques, M.P.M.; Cibin, G.; Gianolio, D.; Cinque, G.; Kelley, C.; Gardner, P.; Pilling, M.; et al. "Anticancer Drugs: from Molecule to Cell". Paper presented in Clinical Infrared and Raman Spectroscopy for Medical Diagnosis (CLIRSPEC) Network Conference, 2015. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Correlating Biological Activity and Chemical Fingerprint: Raman Microspectroscopy Studies in Human Cancer Cells". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho, 2015. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Effect of Dietary Phytochemicals in Cancer: Raman Microspectroscopy Studies in Human Breast Cancer Cells". Paper presented in 6 th European Conference on Chemistry for Life Sciences (6 th ECCLS), 2015. Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Cinque, G.; Kelley, C.; Gardner, P.; Pilling, M.; Doherty, J.; Marques, M.P.M.. "Raman Microspectroscopy Study of Cisplatin-like Complexes Behaviour on a Breast Cancer Cell Line". Paper presented in XVI European Conference on the Spectroscopy of Biological Molecules (ECSBM 16), 2015. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Efeito de fitoquimicos da dieta na quimioprevenção do cancro: estudo de espectroscopia de Ramam em cancro de mama". Paper presented in I Encontro Científico NEQ/AAC, 2015. Costa, F.; Ana L. M. Batista de Carvalho; Marques, M.P.M.; Diniz, C.. "Anti-angiogenic Properties of a Paladium Derivative Compound - Pd2Spm". Paper presented in Reunião de Estudantes Investigadores da Universidade do Porto (IJUP),, 2014. Monteiro, J.; Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Impact of a Dietary Antioxidant in Cancer Cells: a Raman Microspectroscopy Study". Paper presented in VIII Congresso Ibérico de Espectroscopia/XXIV Reunión Española de Espectroscopía, 2014. Marques, M.P.M.; Lopes, R.P.; Gianolio, D.; Ana L. M. Batista de Carvalho; Cibin, G.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Parker, S.F.. "Pt-based Anticancer Drugs - DNA-Interaction and Acquired Resistance Probed by EXAFS and Simultaneous INS and Raman Scattering". Paper presented in SPEC 2014, 2014. Batista de Carvalho, L.A.E.; Parker, S.F.; Batista de Carvalho, A.L.M.; Amado, A.M.; Marques, M.P.M.. "Cyclodextrin-encapsulation of Platinum-based Anticancer Drugs". Paper presented in SPEC 2014, 2014. Batista de Carvalho, A.L.M.; Diniz, C.; Marques, M.P.M.. "Pd2-Spm and Docetaxcel as Potential Anti-angiogenic Agents: An In-vivo Study". Paper presented in XXIII EFMC-ISMC Symposium (XXIII International Symposium on Medicinal Chemistry), 2014. Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Probing the Cellular Impact of Cisplatin on Human Breast Cancer Cells: a Raman Microspectroscopy Study". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014. Matos, C.S.M.; Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Pt(II) and Pd(II) Polyamine Complexes as Promising Anticancer Approaches Towards Metastatic Prostate Cancer". Paper presented in Atualizações em Oncologia, Congress Cimago 2013, 2013. Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "In Vitro Probing of Human Refractory Prostate Cancer Cells by MicroRaman Spectroscopy". Paper presented in 38º FEBS Congress (Federation of European Biochemical Societies) (FEBS2013), 2013. Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "In Vitro Probing of Breast Cancer Cells by Raman Microspectroscopy". Paper presented in XV European Conference on the Spectroscopy of Biological Molecules (ECSBM11), 2013. Matos, C.S.M.; Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Multinuclear Pt(II) and Pd(II) Polyamine Complexes as Promising Anticancer Approaches Towards Metastatic Prostate Cancer". Paper presented in XI International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy, 2012. Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Anti-Metastatic Activity of a Pd(II)-Spermine Complex Against Human Breast Cancer". Paper presented in XI International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy, 2012. Ana L. M. Batista de Carvalho; Fiuza, S.M.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) and Pd(II) Complexes with Linear Diamines - An INS Study". Paper presented in VII Congresso Ibérico de Espectroscopia/XXIII Reunión Española de Espectroscopía, 2012. Batista de Carvalho, A.L.M.; Fiuza, S.M.; Amado, A.M.; Marques, M.P.M.; Batista de Carvalho, L.A.E.. "Vibrational Study of Pt(dap)Cl2 and Pd(dap)Cl2". Paper presented in XIV European Conference on the Spectroscopy of Biological Molecules, 2011. Ana L. M. Batista de Carvalho; Agostinelli, E.; Viceconte, N.; Saccoccio, S.; Bidollari, E.; Nalli, M.; Morera, E.; Ortar, G.; Tempera, G.. "Overcoming Multi-drug Resistance - Polyamine Oxidative Products as Potential Cytotoxics". Paper presented in XVII Congresso Nacional de Bioquímica, 2010. Batista de Carvalho, A.L.M.; Fiuza, S.M.; Amado, A.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Conformational Analysis of Pt(II) and Pd(II) Ethylenediamine Complexes". Paper presented in V Congresso Ibérico de Espectroscopia (V CIE), 2008.
Journal article	Laginha, Raquel C.; Silva, Jéssica D.; Cinque, Gianfelice; Batista de Carvalho, Luís A.E.; Ana L. M. Batista de Carvalho. "Vibrational microspectroscopy as a tool to unveil new chemotherapeutic strategies against osteosarcoma". Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 317 (2024): 124389. http://dx.doi.org/10.1016/j.saa.2024.124389. 10.1016/j.saa.2024.124389 de Carvalho, Luis A. E. Batista; Cinque, Gianfelice; Ana L. M. Batista de Carvalho; Marques, Joana; Frogley, Mark D.; Vondracek, Hendrik; Marques, Maria Paula M.. "Synchrotron nano-FTIR spectroscopy for probing anticancer drugs at subcellular scale". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-67386-y. 10.1038/s41598-024-67386-y Maria M. Félix; Mariana V. Tavares; Inês P. Santos; Ana L. M. Batista de Carvalho; Luís A. E. Batista de Carvalho; Maria Paula M. Marques. "Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy". Molecules 29 5 (2024): https://doi.org/10.3390/molecules29050922. Published • 10.3390/molecules29050922 Carneiro, Tatiana J.; Ana L. M. Batista de Carvalho; Vojtek, Martin; Laginha, Raquel C.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer". Journal of Medicinal Chemistry (2024): Published Bispo, Daniela S. C.; Correia, Marlene; Carneiro, Tatiana J.; Martins, Ana S.; Reis, Aliana A. N.; Batista de Carvalho, A.L.M.; Marques, Maria P. M.; Gil, Ana M.. "Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells". International Journal of Molecular Sciences 24 24 (2023): 17556. http://dx.doi.org/10.3390/ijms242417556. 10.3390/ijms242417556 Carneiro, Tatiana J.; A.L.M., Batista de Carvalho; Vojtek, Martin; Carmo, Inês F.; Marques, MPM; Diniz, Carmen; Gil, Ana M.. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics". Cancer Cell International 23 1 (2023): http://dx.doi.org/10.1186/s12935-023-03124-0. 10.1186/s12935-023-03124-0 Marques, M. P. M.; A.L.M., Batista de Carvalho; Martins, C. B.; Silva, J. D.; Sarter, M.; García Sakai, V.; Stewart, J. R.; de Carvalho, L. A. E. Batista. "Cellular dynamics as a marker of normal-to-cancer transition in human cells". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-47649-w. 10.1038/s41598-023-47649-w Pinto, Sara M. A.; Ferreira, Ana R. R.; Teixeira, Daniela S. S.; Nunes, Sandra C. C.; Batista de Carvalho, A.L.M.; Almeida, Joseany M. S.; Garda, Zoltan; et al. "Fluorinated Mn(III)/(II)-Porphyrin with Redox-Responsive 1H and 19F Relaxation Properties". Chemistry - A European Journal 29 53 (2023): http://dx.doi.org/10.1002/chem.202301442. 10.1002/chem.202301442 Martin Vojtek; Clara B. Martins; Raquel Ramos; Sara Gomes Duarte; Isabel M. P. L. V. O. Ferreira; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Carmen Diniz. "Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041205. 10.3390/pharmaceutics15041205 Jéssica D. Silva; Joana Marques; Inês P. Santos; Ana L. M. Batista de Carvalho; Clara B. Martins; Raquel C. Laginha; Luís A. E. Batista de Carvalho; Maria Paula M. Marques. "A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line". Molecules (2023): https://doi.org/10.3390/molecules28041698. 10.3390/molecules28041698 Raquel C. Laginha; Clara B. Martins; Ana L. C. Brandão; Joana Marques; M. Paula M. Marques; Luís A. E. Batista de Carvalho; Inês P. Santos; Ana L. M. Batista de Carvalho. "Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24031888. 10.3390/ijms24031888 Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213773. 10.3390/ijms232213773 Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; João R. Neves; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice". Pharmaceutics 14 2 (2022): 259-259. https://doi.org/10.3390/pharmaceutics14020259. 10.3390/pharmaceutics14020259 Martin Vojtek; Salomé Gonçalves-Monteiro; Patrícia Šeminská; Katarína Valová; Loreto Bellón; Patrícia Dias-Pereira; Franklim Marques; et al. "Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10020210. 10.3390/biomedicines10020210 Inês P. Santos; Clara B. Martins; Luís A. E. Batista de Carvalho; Maria P. M. Marques; Ana L. M. Batista de Carvalho. "Who's Who? Discrimination of Human Breast Cancer Cell Lines by Raman and FTIR Microspectroscopy". Cancers (2022): https://doi.org/10.3390/cancers14020452. 10.3390/cancers14020452 Adriana P. Mamede; Inês P. Santos; Ana L. M. Batista de Carvalho; Paulo Figueiredo; Maria C. Silva; Maria P. M. Marques; Luís A. E. Batista de Carvalho. "Breast cancer or surrounding normal tissue? A successful discrimination by FTIR or Raman microspectroscopy". The Analyst (2022): https://doi.org/10.1039/D2AN00622G. 10.1039/D2AN00622G M. P. M. Marques; I. P. Santos; A. L. M. Batista de Carvalho; A. P. Mamede; C. B. Martins; P. Figueiredo; M. Sarter; V. García Sakai; L. A. E. Batista de Carvalho. "Water dynamics in human cancer and non-cancer tissues". Physical Chemistry Chemical Physics (2022): https://doi.org/10.1039/D2CP00621A. 10.1039/D2CP00621A Mamede, Adriana P.; Santos, Inês P.; Batista de Carvalho, Ana L. M.; Figueiredo, Paulo; Silva, Maria C.; Tavares, Mariana V.; Marques, Maria P. M.; Batista de Carvalho, Luís A. E.. "A New Look into Cancer - A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance". Cancers 13 21 (2021): 5336. http://dx.doi.org/10.3390/cancers13215336. 10.3390/cancers13215336 Mamede, Adriana P.; Santos, Inês P.; Ana L. M. Batista de Carvalho; Figueiredo, Paulo; Silva, Maria C.; Tavares, Mariana V.; Marques, Maria P. M.; Batista de Carvalho, Luís A. E.. "A New Look into Cancer - A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance". Cancers 13 21 (2021): 5336. http://dx.doi.org/10.3390/cancers13215336. Published • 10.3390/cancers13215336 Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model". International Journal of Molecular Sciences 22 19 (2021): 10775-10775. https://doi.org/10.3390/ijms221910775. 10.3390/ijms221910775 Cristiana L. Pires; Catarina Praça; Patrícia A. T. Martins; Ana L. M. Batista de Carvalho; Lino Ferreira; Maria Paula M. Marques; Maria João Moreno. "Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13101563. 10.3390/pharmaceutics13101563 Ana S. Martins; Ana L. M. Batista de Carvalho; Maria P. M. Marques; Ana M. Gil. "Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs". Molecules (2021): https://doi.org/10.3390/molecules26164805. 10.3390/molecules26164805 Batista de Carvalho, Luis Alberto Esteves; Mamede, Adriana Pereira; Batista de Carvalho, Ana Lucia Marques; Marques, Joana; Cinque, Gianfelice; Rudic, Svemir; Marques, Maria Paula Matos. "Metallodrug-protein interaction probed by synchrotron terahertz and neutron scattering spectroscopy". Biophysical Journal 120 15 (2021): 3070-3078. http://dx.doi.org/10.1016/j.bpj.2021.06.012. 10.1016/j.bpj.2021.06.012 Martin Vojtek; Salomé Gonçalves-Monteiro; Edgar Pinto; Sára Kalivodová; Agostinho Almeida; Maria P. M. Marques; Ana L. M. Batista de Carvalho; et al. "Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice". Pharmaceuticals 14 2 (2021): 173-173. https://doi.org/10.3390/ph14020173. 10.3390/ph14020173 Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Ana M. Gil. "Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent". Metabolites 11 2 (2021): 114-114. https://doi.org/10.3390/metabo11020114. 10.3390/metabo11020114 M. P. M. Marques; A. L. M. Batista de Carvalho; A. P. Mamede; A. Dopplapudi; V. García Sakai; L. A. E. Batista de Carvalho. "Role of intracellular water in the normal-to-cancer transition in human cells—insights from quasi-elastic neutron scattering". Structural Dynamics (2020): https://doi.org/10.1063/4.0000021. 10.1063/4.0000021 Martins, Ana S.; Batista de Carvalho, Ana L.M.; Lamego, Inês; Marques, M.¿ Paula. M.; Gil, Ana M.. "Cytotoxicity of Platinum and Palladium Chelates against Osteosarcoma". ChemistrySelect 5 20 (2020): 5993-6000. http://dx.doi.org/10.1002/slct.202001361. 10.1002/slct.202001361 M. Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Svemir Rudic; Madhusudan Tyagi; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. "A New Look into the Mode of Action of Metal-Based Anticancer Drugs". Molecules 25 2 (2020): 246-246. https://doi.org/10.3390/molecules25020246. 10.3390/molecules25020246 Marques, M. P. M.; Batista de Carvalho, A.L.M.; Mamede, A. P.; Rudic, S.; Dopplapudi, A.; García Sakai, V.; Batista de Carvalho, L. A. E.. "Intracellular water as a mediator of anticancer drug action". International Reviews in Physical Chemistry 39 1 (2020): 67-81. http://dx.doi.org/10.1080/0144235x.2020.1700083. 10.1080/0144235x.2020.1700083 Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; C Diniz; Ana Batista de Carvalho; MPM Marques; Ana M. Gil. "Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice". Metabolites (2019): https://www.mdpi.com/2218-1989/9/11/279. 10.3390/metabo9110279 Maria Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Inês P. Santos; Victoria García Sakai; Asha Dopplapudi; Gianfelice Cinque; et al. "Chemotherapeutic Targets in Osteosarcoma: Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering". The Journal of Physical Chemistry B (2019): https://doi.org/10.1021/acs.jpcb.9b05596. 10.1021/acs.jpcb.9b05596 Ana L. M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Victoria Garcia Sakai; James Doherty; Mark Frogley; Gianfelice Cinque; et al. "Anticancer drug impact on DNA - a study by neutron spectroscopy coupled with synchrotron-based FTIR and EXAFS". Physical Chemistry Chemical Physics (2019): https://doi.org/10.1039/C8CP05881D. 10.1039/C8CP05881D Lucas D. Dias; Ana Batista de Carvalho; Sara Pinto; Gilberto; Mário J. F. Calvete; Liane M. Rossi; M. P. M. Marques; Mariette M. Pereira. "Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63)". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/52. 10.3390/molecules24010052 Batista de Carvalho, A.L.M.; Parker, S.F.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Novel platinum-based anticancer drug: a complete vibrational study". Acta Crystallographica Section C: Structural Chemistry 74 5 (2018): 628-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046549535&partnerID=MN8TOARS. 10.1107/S2053229618005843 Batista de Carvalho, A.L.M.; Caselli, F.; Rodrigues, V.; Paiva-Martins, F.; Marques, M.P.M.. "Antiproliferative Activity of Olive Oil Phenolics against Human Melan oma Cells". Letters in Drug Design & Discovery 14 9 (2017): 1053-1059. Published • 10.2174/1570180814666170110145658 Marques, M.P.M.; Batista De Carvalho, A.L.M.; Sakai, V.G.; Hatter, L.; Batista De Carvalho, L.A.E.; Garcia-Sakai, V.. "Intracellular water-an overlooked drug target? Cisplatin impact in cancer cells probed by neutrons". Physical Chemistry Chemical Physics 19 4 (2017): 2702-2713. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021304395&partnerID=MN8TOARS. Published • 10.1039/c6cp05198g De Carvalho, A.L.M.B.; Medeiros, P.S.C.; Costa, F.M.; Ribeiro, V.P.; Sousa, J.B.; Diniz, C.; Marques, M.P.M.. "Anti-invasive and anti-proliferative synergism between docetaxel and a polynuclear Pd-spermine agent". PLoS ONE 11 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84996537166&partnerID=MN8TOARS. 10.1371/journal.pone.0167218 A. L. M. Batista de Carvalho; M. Pilling; P. Gardner; J. Doherty; G. Cinque; K. Wehbe; C. Kelley; et al. "Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy". Faraday Discussions 187 - (2016): 273-298. https://doi.org/10.1039/C5FD00148J. Published • 10.1039/C5FD00148J Medeiros, P.S.C.; Batista De Carvalho, A.L.M.; Ruano, C.; Otero, J.C.; Marques, M.P.M.; Frias, C.R.. "Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells". Food and Function 7 6 (2016): 2800-2810. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975454450&partnerID=MN8TOARS. Published • 10.1039/c6fo00209a Batista de Carvalho, A.L.M.; Marques, M.P.M.; Frias, C.R.; Otero, J.C.. "In Vitro Probing of Human Refractory Prostate Cancer Cells by MicroRaman Spectroscopy". FEBS Journal- Main Symposia And Workshops 280 -- (2013): 3-617. Published • 10.1111/febs.12340 Ana L. M. Batista de Carvalho; Fiuza, S.M.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) Complexes with Linear Diamines - Part I: Vibrational Study of Pt-Diaminopropane Dichloride". Spectroscopy: An International Journal 27 5-6 (2012): 403-413. Published • 10.1155/2012/206297 Matos, C.S.; Ana L. M. Batista de Carvalho; Lopes, R.P.; Marques, M.P.M.. "New strategies against prostate cancer - Pt(II)-based chemotherapy". Current Medicinal Chemistry 19 27 (2012): 4678-4687. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875266301&partnerID=MN8TOARS.
Preprint	Cristiana L. Pires; Susana Rosa; Ana L. M. Batista de Carvalho; Lino Ferreira; Maria Paula M. Marques; Maria João Moreno. "Re-Use of Caco-2 Monolayers for a Higher Throughput Assessment of Drug Permeability – Methodology and Validation for Passive Permeation". 2024. https://doi.org/10.20944/preprints202405.2057.v1. 10.20944/preprints202405.2057.v1
Report	A.L.M., Batista de Carvalho. 2022. Synchrotron Terahertz and Neutron Scattering Spectroscopies to Pave the Way to Understand Chemoresistance. https://www.diamond.ac.uk/docroot/flippingbooks/DiamondAnnualReview2022/index.html. Marques, M.P.M.; Ana L. M. Batista de Carvalho; Martins, C.; Sarter, M.; Stewart, R; Garcia-Sakai, V.; Batista De Carvalho, L.A.E.. 2022. Cellular Dynamics as a Marker of Normal-to-Cancer Transformation. https://doi.org/10.5286/ISIS.E.RB2210188. Marques, M.P.M.; Ana L. M. Batista de Carvalho; Santos, I.; Mamede, Adriana; Garcia-Sakai, V.; Batista De Carvalho, L.A.E.. 2021. Probing Water Dynamics in Healthy and Cancer Human Tissues by QENS. https://doi.org/10.5286/ISIS.E.RB2010015. Marques, MPM; Ana L. M. Batista de Carvalho; A. P. Mamede; Dopplapudi, A.; García Sakai, V.; Batista De Carvalho, L.A.E.. 2021. Understanding Normal-to-Cancer Transition in Human Cells with the Use of Neutrons. https://doi.org/10.5286/ISIS.E.RB1910015. Marques, MPM; Ana L. M. Batista de Carvalho; Marques, J.; Rudic, S.; Batista De Carvalho, L.A.E.. 2020. Probing Chemoresistance to Pt- and Pd-Drugs by INS Spectroscopy. https://doi.org/10.5286/ISIS.E.RB2010013. Marques, MPM; Ana L. M. Batista de Carvalho; A. P. Mamede; García Sakai, V.; Dopplapudi, A.; Batista De Carvalho, L.A.E.. 2019. Understanding Normal-to-Cancer Transformation in Human Cells with the Use of Neutrons. https://doi.org/10.5286/ISIS.E.RB1910015. Marques, MPM; Ana L. M. Batista de Carvalho; Rudic, S.; Batista De Carvalho, L.A.E.. 2019. Probing Drug Pharmacodynamics by INS: The Effect of Cisplatin-like Anticancer Drugs on DNA. https://doi.org/10.5286/ISIS.E.RB1820103. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Dopplapudi, A.; Batista De Carvalho, L.A.E.. 2018. Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma. https://doi.org/10.5286/ISIS.E.RB1810012. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Batista De Carvalho, L.A.E.. 2017. Probing Drug Pharmacodynamics by QENS - The Effect of Cisplatin-Like Anticancer Drugs on DNA Dynamical Profile. https://doi.org/10.5286/ISIS.E.RB1710167. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Batista De Carvalho, L.A.E.. 2017. Intracellular Water as a Secondary Drug Target in Chemotherapy: The Impact of a New Pd-Based Anticancer Agents on Human Breast Cancer Cells. https://doi.org/10.5286/ISIS.E.RB1620050. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Hatter, L.; Batista De Carvalho, L.A.E.. 2015. Drug Effects on Intracellular Water Dynamics: Cisplatin in Human Cancer Cells. https://doi.org/10.5286/ISIS.E.RB1510054. Batista De Carvalho, L.A.E.; Ana L. M. Batista de Carvalho; García Sakai, V.; Hatter, L.; Vaz, P.D.; Marques, MPM. 2015. Drug Effects on Intracellular Water: Cisplatin in Human Cancer Cells. https://doi.org/10.5286/ISIS.E.RB1510053.
Thesis / Dissertation	Carvalho, Ana Lúcia Marques Batista de. "Cisplatin-like Compounds as Potential Chemotherapeutics: from the Bench to the Cell". 2017. http://hdl.handle.net/10316/31864.

Other

Other output

Intracellular water could help us distinguish between healthy and malignant cells. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2021 (highlight). 2021. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. https://www.isis.stfc.ac.uk/Pages/SH20_IntracellularWater.aspx.
Metallodrug-protein Interaction Probed by Synchrotron Terahertz and Neutron Scattering Spectroscopy. Diamond Light Source Annual Report (2021) (highlight). 2021. A.L.M., Batista de Carvalho.
Probing Chemoresistance to Pt- and Pd-Drugs via THz Spectroscopy. Diamond Light Source Annual Report 2019. 2019. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Gianfelice Cinque; Luís A. E. Batista de Carvalho.
Probing Drug Pharmacodynamics by INS: The Effect of Cisplatin-like Anticancer Drugs on DNA. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2019. 2019. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Svemir Rudic; Adriana P. Mamede; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1820103.
Anticancer Drug Impact on DNA - A Study by Neutron Spectrocopy, Synchrotron-based FTIR and EXAFS. 2018. Ana L.M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Victoria Garcia Sakai; James Doherty; Mark Frogley; Gianfelice Cinque; et al. https://doi.org/10.1101/398826.
10.1101/398826
Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma. Diamond Light Source Annual Report 2018. 2018. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Gianfelice Cinque; Luís A. E. Batista de Carvalho.
An EXAFS Approach to the Pharmacodynamics of Unconventional Pt- and Pd-Based Anticancer Drugs. Diamond Light Source Annual Report 2018. 2018. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Diego Gianolio; Luís A. E. Batista de Carvalho.
Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2018. 2018. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Victoria Garcia Sakai; Asha Dopplapudi; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1810012.
Probing Drug Pharmacodynamics by QENS - The Effect of Cisplatin-Like Anticancer Drugs on DNA Dynamical Profile. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2017. 2017. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1710167.
Intracellular Water as a Secondary Drug Target in Chemotherapy: The Impact of a New Pd-Based Anticancer Agents on Human Breast Cancer Cells. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2017. 2017. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1620050.
Drug Effects on Intracellular Water: Cisplatin in Human Cancer Cells RB1510053. 2015. Batista de Carvalho, L.A.E.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Hatter, L.; Vaz, P.D.; Marques, M.P.M..
Drug Effects on Intracellular Water Dynamics: Cisplatin in Human Breast Cancer Cells RB1400034. 2014. Marques, M.P.M.; Hatter, L.; Parker, S.F.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Batista de Carvalho, L.A.E..

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/10/23	Vibrational Microspectroscopy in Cells	Workshop Cells Meet Good Vibrations - Bridging Biochemistry and Vibrational Spectroscopy in Stem Cell Research University of Aveiro (Aveiro, Portugal)
2024/09	New Routes for Cancer Treatment Tackled by Neutrons	20th European Conference on the Spectroscopy of Biological Molecules (ECSBM) Lodz University of Technology (Lodz, Poland)
2024/09	Stem Cell Differentiation into Bone - probing Cellular Events by Vibrational Spectroscopy	20th European Conference on the Spectroscopy of Biological Molecules (ECSBM) Lodz University of Technology (Lodz, Poland)
2024/08	Vibrational Spectroscopy Paving the Way into Biomedical Applications	LAPS 2024 - The Latin American Photodiagnosis Symposium Universidade Federal de Mato Grosso do Sul - UFMS (Campo Grande, Brazil)
2024/05	A Palladium Complex against Breast Cancer: Metabolic Impact Analysis by Raman Microspectroscopy	4th Meeting of Young Biophysicists - Biophysics Festival’24 Universidade da Beira-Interior (Portugal)
2024	Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy	4th Meeting of Young Biophysicists - Biophysics Festival’24 Universidade da Beira-Interior (Portugal)
2024	Shining Insight: Probing Lung Cancer Cells With a Non-Conventional Platinum Complex	4th Meeting of Young Biophysicists - Biophysics Festival’24 Universidade da Beira-Interior (Portugal)
2024	Metabolic Impact of Palladium Complex and Cisplatin on TNBC: Raman Microspectroscopy as a Key	iBiMed Symposium Universidade de Aveiro (Portugal)
2023/11/01	New Strategies to Fight Cancer - The Role of Neutrons	The Simulation Meets Molecular Spectroscopy (SiMol) Meeting
2023/11	Liver Graft rejection diagnosis by vibrational spectroscopy	Reunião do Serviço de Anatomia Patológica do CHUC (Coimbra, Portugal)
2023/10/26	Development of Palladium-spermine complex (Pd2Spm) for triple-negative breast cancer cells - in vitro and in vivo	X Congresso Iberoamericano de Ciências Farmacêuticas
2023/10/11	Advantages of FTIR Microspectroscopy with Synchrotron Radiation - an Inside View into Osteosarcoma Treatment	European Large-Scale Facilities and the Research Infrastructures: Opportunities and How to Apply (Portugal)
2023/09/01	Thriving Advantages of Drug Combination in Osteosarcoma Treatment - A Vibrational Microspectroscopy Study	12th International Conference on Advanced Vibrational Spectroscopy (ICAVS12) (Poland)
2023/08/27	Advantages of FTIR Microspectroscopy with Synchrotron Radiation - an Inside View into Osteosarcoma Treatment	9º Encontro Nacional de Utilizadores de Radiação de Sincrotrão (Portugal)
2023/07/08	NMR Metabolomics Unveils a Beneficial Metabolic Response of Mice Brain to Pd2Spermine, a Possible Alternative to Cisplatin in Cancer Treatment	19th European Magnetic Resonance Congress (EuroMar2023) (United Kingdom)
2023/04/20	Shining the Beam on Human Cells and Tissues	Molecular Spectroscopy Group Seminar Series Royal Society of Chemistry
2023/04/04	Vibrational Microspectroscopy for the Discrimination of Breast Cancer Cell Lines	XV Encontro Nacional de Química-Física Sociedade Portuguesa de Química (Portugal)
2023	Pt and Pd-Complexes Against Breast Cancer	International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship (4th edition) (Portugal)
2022	Shining the Beam on Water in Human Cells and Tissues	3rd ESS ILL User Meeting
2022	The Biochemical Profile of Breast Cancer - Diagnosing with Raman Spectroscopy	27th International Conference on Raman Spectroscopy (ICORS)
2022	Role of Water Dynamics in Normal-to-Cancer Transition - Insights from Neutron Scattering Techniques	12th International Conference on Clinical Spectroscopy (SPEC 2022)
2022	Fluorinated Platforms for MRI Imaging	14º Encontro Nacional de Química Orgânica & 7º Encontro Nacional de Química Medicinal
2021	Intracellular Water Dynamics as a Mediator of Chemotherapy-induced Cell Death	QENS-WINS 2021 Conference
2021	Normal-to-Cancer Transition - Insights from Quasi-elastic Neutron Scattering	ICAVS11 Conference
2021	Anticancer Activity of Palladium-spermine Complex Against Triple-negative Breast Cancer	8th European Congress of Pharmacology (EPHAR 2021)
2020/01/08	Compostos Anticancerígenos - Novos medicamentos para o tratamento do cancro	Programa Cientificamente Provável Escola Secundária D. Duarte (Coimbra, Portugal)
2019	Shining the Beam on Cells - Intracellular Water as a Mediator of Anticancer Drug Action	UK Neutron and Muon Science and User Meeting (NMSUM) 2019
2019	Probing Drug Pharmacodynamics by Optical and Neutron-based Vibrational Spectroscopy: Interaction of Cisplatin-like Anticancer Agents with DNA	10th International Conference on Advanced Vibrational Spectroscopy (ICAVS10)
2019	Shining the Beam on Biosystems: From Cancer Cells to Bones	ILL – Synergies with Portugal Workshop,
2019	Synchrotron-based FTIR and Quasi-elastic Neutron Scattering in the Search for New Chemotherapeutic Targets Against Osteosarcoma	XVIII European Conference on the Spectroscopy of Biological Molecules (ECSBM 18)
2019	Nuclear Magnetic Resonance Metabolomics to Evaluate the Metabolic Impact of Cisplatin and a Potential New Anti-cancer Drug - Palladium(II)-spermine - in a Mouse Model	III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship
2018/10/12	Early Investigator Session - Ana Batista de Carvalho	Raman4Clinics Summer School (Coimbra, Portugal)
2018	Anticancer Metal-Polyamine Complexes Against Breast Cancer	11º Encontro de Investigação Jovem da Universidade do Porto (IJUP18)
2018	Anticancer Metal Complexes with Polyamines Against Breast Cancer: Cellular Uptake and Selective Cytotoxicity	XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia
2018	Water - a Potential New Target for Chemotherapeutic Intervention?	UK Neutron and Muon Science and User Meeting (NMSUM) 2018
2018	Searching for New Drug Targets - The Impact of Anticancer Drugs on Intracellular Water Probed by Neutron Spectroscopy	SPEC Conference (SPEC 2018) – Shedding New Light on Disease
2018	Shining the Beam on Cells - In Search of Improved Anticancer Drugs	7th Annual Niels Bohr International Academy Workshop-School on ESS Science in Copenhagen (NBIA7): Deciphering the Hidden Dynamics of Soft Matter
2018	Metalloprophyrin as a Catalyst for the Synthesis of Diatereomeric (-)-isopulegol Epoxide: Antiproliferative Activity Against Human Osteosarcoma	7th EuCheMS Conference on Nitrogen Ligands
2017	Probing Breast Cancer Cells with Neutrons: The Impact of Anticancer Drugs on Intracellular Water	(United Kingdom)
2016	Synergetic Effect Induced by Docetaxel and Pd-spermine Complex in Human Triple Negative Breast Cancer	Farmadrid (Madrid, Spain)
2016	Vibracional Spectroscopy - Applications in Forensic and Medicinal Chemistry	ANALÍTICA – 2016, 8º Encontro da Divisão de Química Analítica (Lisboa, Portugal)
2016	Novel Chemotherapeutic Strategies Probed by Raman Spectroscopy	Meeting of the COST-BM1401 Working Group – Raman-based Applications for Clinical Diagnostics (Raman4Clinics) (Jena, Germany)
2016	Chemotherapeutic Response to Cisplatin-like Drugs in Human Breast Cancer Cells Probed by Vibrational Microspectroscopy	Faraday Discussion “Advanced Vibrational Spectroscopy for Biomedical Applications (Cambridge, United Kingdom)
2015	MicroRaman Spectroscopic Signature of Drug Action: Pd-Based Anticancer Agents Against Human Breast Cancer	8th International Conference on Advance Vibrational Spectroscopy (ICAVS 8) (Viena, Austria)
2015	Spectral Signature of Drug Action - from the Bench to the Cell	XVI European Conference on the Spectroscopy of Biological Molecules (ECSBM 16) (Bochum, Germany)
2015	Efeito de Compostos Fenólicos Presentes na Dieta: Caso de Estudo por Espectroscopia de Raman em Células de Cancro de Mama	Cientific Meeting of Chemistry Students Association of the University of Coimbra (NEQ/AAC) (Coimbra, Portugal)
2012	Platinum and Palladium-based Anticancer Strategies - A Molecular View	VII CIE (VII Congresso Ibérico de Espectroscopia/XXIII Reunión Española de Espectroscopía) (Cordoba, Spain)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/10/01 - Current	From Bench to Cell: A Roadmap to Fight Lung Cancer Based on Ni-Agents Supervisor	Biosciences (PhD) Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
2022/09 - Current	Liver Graft Rejection Diagnosis by Vibrational Spectroscopy Supervisor	Biosciences (PhD) Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
2020/12 - Current	New Drugs to Fight Breast Cancer: a Close Look into Cellular Response Co-supervisor	Biosciences (PhD) Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
2024/10 - 2028/10	Unlocking Potential: The Wonders of Drug Combinations in Liver Cancer Treatment Supervisor	Biological Chemistry (PhD) Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2024/09 - 2028/09	A Novel Look into Endometrial Cancer Diagnosis through Vibrational Spectroscopy and Machine Learning Supervisor	Health Sciences (PhD) Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2023 - 2027	Endometrial Polyps and Hysteroscopic Fluid Analysis: Frtom Prediction of Malignancy to Therapeutic Options Co-supervisor	Health Sciences (PhD) Universidade de Coimbra, Portugal
2022/09 - 2023/09	Estudo de complexos análogos de Pt(II) e Pd(II) em linha celular de osteossarcoma por microespectroscopia vibracional Supervisor	Chemistry (Master) Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07	Estudo do impacto da cisplatina em linha celular saudável de próstata PNT-2 por microespectroscopia de FTIR Supervisor	Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07	Estudo do impacto da cisplatina em linha celular saudável de próstata PNT-2 por microespectroscopia de Raman Supervisor	Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07	Novos métodos de diagnóstico percoce de rejeição hepática - microespectroscopia de Raman Supervisor	Medicinal Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07	Novos métodos de diagnóstico precoce de rejeição hepática - microespectroscopia de FTIR Co-supervisor	Medicinal Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2022 - 2022	Desenvolvimento de Novos Agentes Anticancerígenos com Pd(II) Contra o Cancro do Cólon - Estudo por Microespetroscopia Vibracional Supervisor	Medicinal Chemistry (Degree) Universidade de Coimbra, Portugal
2020/09 - 2021/12	New Pt and Pd-based Anticancer Agents Toward Colon Cancer Co-supervisor	Biochemistry (Master) Universidade de Coimbra, Portugal
2021/02 - 2021/07	Resposta Quimioterapêutica de Compostos de Pd(II) em Células Humanas de Cancro da Próstata por Microespetroscopia de Raman Supervisor	Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2021/02 - 2021/07	Resposta Quimioterapêutica de Compostos de Pd(II) em Células Humanas de Cancro da Próstata por Microespetroscopia de FTIR Supervisor	Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2021/02 - 2021/07	Pt(II) and Pd(II) Polyamine Complexes as Novel Anticancer Agents Co-supervisor	Medicinal Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2020/02 - 2020/07	Identificação de biomarcadores espectrais em linhas celulares de cancro de mama por micro-espectroscopia de Raman Supervisor	Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2020/02 - 2020/07	Identificação de biomarcadores espectrais em linhas celulares de cancro de mama por micro-espectroscopia de FTIR Supervisor	Chemistry (Degree) Universidade de Coimbra Departamento de Química, Portugal
2019 - 2019	Poder antioxidante da Corema album Supervisor	Unidade I&D Química-Físicia Molecular, Portugal
2018 - 2018	Valorização da planta halófita Salicornia ramosissima: nova formulação de bolachas e outros estudos biológicos Co-supervisor	Unidade I&D Química-Físicia Molecular, Portugal
2018 - 2018	A contribution to the valorisation of a marine plant: Corema album Co-supervisor	Unidade I&D Química-Físicia Molecular, Portugal
2018 - 2018	Efeitos do Crómio Hexavalente em Células Epiteliais de Pulmão Humano Co-supervisor	Unidade I&D Química-Físicia Molecular, Portugal
2017 - 2017	Desenvolvimento de Agentes Quimiopreventivos e Quimioterapêuticos (de Pt (II)e Pd(II)) – Estudo por Espectroscopia Vibracional e Ensaios de Biologia Celular Co-supervisor	Unidade I&D Química-Físicia Molecular, Portugal
2017 - 2017	Ensaios de Avaliação da Atividade Biológica de Compostos Fenólicos em Células Tumurais Humanas Co-supervisor	Unidade I&D Química-Físicia Molecular, Portugal
2016 - 2016	Enhancement of wine antioxidant capacity by development of an innovative production methodology - new insights on the in vitro anthocyanin gut absorption Co-supervisor	Técnicas de Cultura Celular (Other) Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014	Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico) Supervisor	Cursos de Verão da Universidade de Coimbra (Other) Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014	Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico) Supervisor	Cursos de Verão da Universidade de Coimbra (Other) Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014	Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico) Supervisor	Cursos de Verão da Universidade de Coimbra (Other) Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014	Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico) Supervisor	Cursos de Verão da Universidade de Coimbra (Other) Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014	Correlating Biological Activity and Chemical Fingerprint: Raman Microspectroscopy Studies in Human Breast Cancer Cells Supervisor	Bioquímica (Other) Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014	Anti-angiogenic Properties of a Palladium Derivative Compound: Pd2Spm Supervisor	Técnicas de manipulação de CAM (Other) Universidade do Porto, Portugal
2013 - 2013	A Novel Integration Approach:Perturbation Studies in Vitro using PDK1/Akt Inhibitor in Glioblastoma Multiforme Supervisor	Técnicas de Cultura Celular (Other) Unidade I&D Química-Físicia Molecular, Portugal
2013 - 2013	Olive Oil Components as Potential Chemopreventive Agents Against Cancer - Cell Biology Studies Supervisor	Técnicas de Cultura Celular (Other) Unidade I&D Química-Físicia Molecular, Portugal
2012 - 2012	Phytochemicals as Chemopreventive Agents Towards Cancer - Structure-Activity Relationships Supervisor	Técnicas de Cultura Celular (Other) Unidade I&D Química-Físicia Molecular, Portugal
2012 - 2012	A Microespectroscopia Raman como Biosensor - Aplicação em Células Humanas Supervisor	Técnicas de Espectroscopia Vibracional (Other) Unidade I&D Química-Físicia Molecular, Portugal
2011 - 2011	Phytochemicals from Olive Oil as Cancer Chemopreventive Agents Supervisor	Técnicas de Cultura Celular (Other) Unidade I&D Química-Físicia Molecular, Portugal
2010 - 2010	Complexos de Pt(II) e Pd(II) com Poliaminas como Potenciais Agentes Anticancerígenos Supervisor	Biochemistry (Master) Unidade I&D Química-Físicia Molecular, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/03/14 - 2019/03/14	5º Workshop do Núcleo de Utilizadores Portugueses de Neutrões&Muões (2019/03/14) Workshop (Member of the Organising Committee)	Neutron and Muon Users in Portugal (NeMPo), Portugal
2018/10/10 - 2018/10/12	Summer School of the COST-BM1401 - Raman-based Applications for Clinical Diagnostics (Raman4Clinics) (2018/10/10 - 2018/10/12) Workshop (Member of the Organising Committee)	Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2018/10/07 - 2018/10/09	Meeting of the COST-BM1401 - Raman-based Applications for Clinical Diagnostics (Raman4Clinics) (2018/10/07 - 2018/10/09) Meeting (Member of the Organising Committee)	Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2017/11/20 - 2017/11/20	2º Workshop do Núcleo de Utilizadores Portugueses de Neutrões&Muões (2017/11/20 - 2017/11/20) Workshop (Member of the Organising Committee)	Neutron and Muon Users in Portugal (NeMPo), Portugal
2017/05/31 - 2017/05/31	1º Workshop do Núcleo de Utilizadores Portugueses de Neutrões&Muões (2017/05/31 - 2017/05/31) Workshop (Member of the Organising Committee)	Neutron and Muon Users in Portugal (NeMPo), Portugal
2011/08/29 - 2011/09/03	XIV European Conference on the Spectroscopy of Biological Molecules (ECSBM 14) (2011/08/29 - 2011/09/03) Conference (Member of the Organising Committee)
2009/04/18 - 2009/04/19	Jornadas Científicas - 30º Aniversário da Licenciatura em Bioquímica (2009/04/18 - 2009/04/19) Conference (Member of the Organising Committee)	Universidade de Coimbra, Portugal
2008/04/24 - 2008/04/25	III Encontro Nacional de Estudantes de Bioquímica (ENEBIOQ) (2008/04/24 - 2008/04/25) Meeting (Member of the Organising Committee)	Universidade de Coimbra, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2018 - 2023	Iniciativa da Secretaria de Estado da Educação, através da Rede de Bibliotecas Escolares e da Secretaria de Estado da Ciência, Tecnologia e Ensino Superior. "Novos Medicamentos para o Tratamento do Cancro" Palestra na escola Secundária Quinta das Flores. Demonstrações laboratoriais (hands-on) na área da Química Medicinal, para alunos do ensino secundário. Exhibition	Programa Cientificamente Provável Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2022 - 2022	–Palestra, workshop e visita aos laboratórios da Unidade de I&D Química-Física Molecular com demonstrações do tipo de investigação realizadas no âmbito da utilização de espetroscopia vibracional Exhibition	Semana da Ciência e da Tecnologia Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2021 - 2021	Dia Aberto da Unidade de I&D Química-Física Molecular - Visita aos laboratórios da Unidade de I&D Química-Física Molecular com demonstrações do tipo de investigação realizadas no âmbito da utilização de espetroscopia vibracional. Exhibition	Semana da Ciência e da Tecnologia Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2019 - 2019	Demonstrações laboratoriais (hands-on) na área da Química Medicinal Exhibition	Escola Secundária José Falcão , Portugal
2019 - 2019	Poluição ambiental por metais: determinação por espectrofotometria de absorção molecular no visível Workshop	Encontro de Ensino e Divulgação da Química da Sociedade Portuguesa de Química Sociedade Portuguesa de Química, Portugal
2018 - 2018	Ocupação científica de jovens nas férias - com actividades laboratoriais e de campo relativas ao estudo de compostos extraídos das plantas (endógenas da região Centro de Portugal) com propriedades benéficas para a saúde. (http://www.cienciaviva.pt/estagios/jovens/ocjf2018/) Exhibition	Ciência Viva no Laboratório (FCT) Fundação para a Ciência e a Tecnologia, Portugal
2015 - 2018	Demonstrações laboratoriais (hands-on) na área da Química Medicinal e Bioquímica Exhibition	Universidade de Verão Centro Hospitalar e Universitario de Coimbra EPE Centro de Simulação Biomédica dos Hospitais da Universidade de Coimbra, Portugal
2017 - 2017	Ocupação científica de jovens nas férias - com actividades laboratoriais e de campo relativas a: (i) estudo de compostos extraídos das plantas com propriedades benéficas para a saúde; (ii) desenvolvimento de novos fármacos (ex. anticancerígenos). (http://www.cienciaviva.pt/estagios/jovens/ocjf2017/) Exhibition	Ciência Viva no Laboratório (FCT) Fundação para a Ciência e a Tecnologia, Portugal
2017 - 2017	Divulgar a ciência que se faz nos centros de investigação da FCTUC, promovendo uma literacia científica Exhibition	1ª Mostra de Ciência Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016	Apresentações teóricas e demonstrações experimentais na área da Quimioprevenção e Quimioterapia, promovida pela Comissão Europeia no âmbito das Ações Marie Curie.	Noite Europeia dos Investigadores (Researchers´ Night) Universidade de Coimbra, Portugal
2015 - 2015	Apresentações teóricas e demonstrações computacionais na área da Química/Desenvolvimento de Fármacos Anticancerígenos, promovida pela Comissão Europeia no âmbito das Ações Marie Curie.	Noite Europeia dos Investigadores (Researchers´ Night) Universidade de Coimbra, Portugal
2015 - 2015	Visita aos laboratórios da Unidade de I&D Química-Física Molecular e demonstrações práticas para alunos dos ensinos básico e secundário de Escolas do distrito de Coimbra	Semana da Ciência e Tecnologia do Museu da Ciência da Universidade de Coimbra Universidade de Coimbra, Portugal
2009 - 2009	Seminários teóricos e atividades laboratoriais para alunos do ensino secundário, organizado pelo Núcleo de Estudantes de Bioquímica da Associação da Académica de Coimbra (NEBIOQ). Exhibition	Dia aberto da Bioquímica Universidade de Coimbra, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023	Desenvolvimento de Novos Agentes Anticancerígenos com Pd(II) Contra o Cancro do Cólon - Estudo por Microespetroscopia Vibracional Supervisor	Bruna Queiroz de Brito (Other) Universidade de Coimbra, Portugal
2023	New Drugs to Fight Osteosarcoma - A Complete Vibrational Microscpectroscopy Study Supervisor	Raquel Cadete Laginha da Silva (Master) Universidade de Coimbra, Portugal
2022	Impact of Adenosine on Sensitivity of Triple Negative Breast Cancer Cells Towards Platinum-Derived Chemotherapeutic Drugs (Thesis) Arguer	Ana Sofia Silva Cerquido (Master) Universidade do Porto, Portugal
2021	Avaliação do impacto metabólico de complexo de Pd-(II) em linha celular de cancro da próstata por microespectroscopia de FTIR Supervisor	Raquel Cadete Laginha da Silva (Other) Universidade de Coimbra, Portugal
2021	Avaliação do impacto metabólico de complexo de Pd-(II) em linha celular de cancro da próstata por microespetroscopia de Raman Supervisor	Beatriz Rodrigues (Other) Universidade de Coimbra, Portugal
2018	Desenvolvimento de Estratégias para a Valorização de uma Planta Endógena da Costa Marítima Portuguesa: a Corema album (L.) D. Don (Thesis) Arguer	Luís Miguel da Silva Simões (Master) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2018	Multiplicação e Estabelecimento in vitro e ex vitro de Salicornia ramosissima (Thesis) Arguer	Marta Susana da Silva Clemente (Master) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Association member

	Society Organization name	Role
2024 - Current	Associação Gira Catavento	Member
2020 - Current	Associação miniBIOQS - Associação Ciência para Todos	Secretária do Conselho Fiscal
2018 - Current	Grupo Português de Utilizadores de Neutrões e Muões (NeMPo)
2016 - Current	Royal Society of Chemistry
2016 - Current	Clirspec
2010 - Current	Portuguese Society of Biochemistry
2020 - 2021	Projeto Student Keep	Voluntária

Conference scientific committee

	Conference name	Conference host
2020/02/19 - 2020/02/20	V Encontro Científico do NEQ/AAC	Núcleo de Estudantes de Química da Associação Académica de Coimbra (NEQ/AAC)

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024 - Current	Química Geral	Engenharia Civil (Licenciatura)	Universidade de Coimbra, Portugal
2022 - Current	Tuturial em Química	Química (Licenciatura)	Universidade de Coimbra Departamento de Química, Portugal
2021/02 - Current	Estrutura e Modelação de Biomacromoléculas	Química Medicinal (Licenciatura)	Universidade de Coimbra Departamento de Química, Portugal
2021 - Current	Desenvolvimento de Fármacos II	Química Medicinal (Licenciatura)	Universidade de Coimbra Departamento de Química, Portugal
2021 - Current	Iniciação à Investigação e Desenvolvimento	Química (Mestrado)	Universidade de Coimbra Departamento de Química, Portugal
2020/02 - Current	Estágio Laboratorial	Química (Licenciatura)	Universidade de Coimbra Departamento de Química, Portugal
2019/09 - Current	Química Biológica	Química/Química Medicinal (Licenciatura)	Universidade de Coimbra Departamento de Química, Portugal
2023 - 2024	Química Geral	Engenharia Biomédica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/03 - 2020/07	Laboratórios de Química II	Química/Química Medicinal (Licenciatura)	Universidade de Coimbra Departamento de Química, Portugal

Mentoring / Tutoring

	Topic	Student name
2023/07 - 2023/09	Avaliação da citotoxicidade de complexos metálicos de Pd(II) e Pt(II) em linha celular de cancro de colon	Sabrina Louise Lopes Pereira
2023/07 - 2023/09	Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de colon por microespectroscopia de Raman	Mariana Isabel Breia Silva
2023/06 - 2023/09	Avaliação da citotoxicidade de complexos metálicos de Pd(II) e Pt(II) em linha celular de cancro de mama	Rita Maria Marrazes Fernandes
2023/08 - 2023/08	Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de colon por microespectroscopias de Infravermelho	João Fernando de Sousa Henriques
2022/06 - 2022/09	Avaliação do efeito citotóxico de complexos metálicos de Pd(II) e Pt(II) em linha celular de pulmão (não tumorais)	Rita Maria Marrazes Fernandes
2022/06 - 2022/07	Novos métodos de diagnóstico de rejeição hepática pós transplantação - espectroscopia vibracional	Catarina Alcobia Montargil
2020/09 - 2021/12	Synthesis and Characterization of a Biocompatible Fluorinated Mn(III)-Porphyrin as a Redox Responsive 19F-NMR/T1 Bimodal MRI Contrast Agent	Ana Rita Rolo Ferreira
2021/06 - 2021/09	Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de próstata (tumorais e não tumorais) por microespectroscopias de Raman e Infravermelho	Raquel Cadete Laginha da Silva
2021/07 - 2021/08	Avaliação da atividade citotóxica e citoestática de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de próstata (tumorais e não tumorais	Carolina dos Santos Neto
2021/07 - 2021/08	Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de próstata (tumorais e não tumorais) por microespectroscopias de Raman e Infravermelho	Inês Gonçalves Cruz
2019/08 - 2019/08	Caracterização de Linhas Celulares de Mama por Microespetroscopia de Raman	Bárbara Lima

Scientific expedition

	Activity description	Institution / Organization
2024/09 - 2024/09	Probing Metallodrug Action on Human Cancer Cells by QSM	ISIS@MACH ITALIA, Italy
2024/08/06 - 2024/08/08	Experiment SP36216: "A Molecular View of Metallodrug-Protein Interaction - Insights Into Drug Transport and Acquired Resistence"	Diamond Light Source Ltd, United Kingdom
2024/02 - 2024/02	Probing drug pharmacokinetics by QENS. The effect of cisplatin-like anticancer agents on HSA blood protein	Institut Laue–Langevin, France
2024/01/24 - 2024/01/29	Experiment SM34385: "Probing Metallodrug Action at the Single Cell Level – SR-FTIR Imaging via FPA on Human Breast Cancer Cells"	Diamond Light Source Ltd, United Kingdom
2023/12 - 2023/12	Experiment SM34458: "THz Spectroscopy - an Unmet Approach to Study DNA Interaction in Osteosarcoma Treatment: Pt(II) and Pd(II) Complexes Application According to the EURAMOS-1 Protocol"	Diamond Light Source Ltd, United Kingdom
2023/05 - 2023/05	Experiment SM33051: "Impact of Metallogrugs on Cellular Membrane Lipids Probed by Combined SR-Infrared Spectroscopy and Neutron Scattering"	Diamond Light Source Ltd, United Kingdom
2022/04 - 2022/04	Experiment SM32861: "Thriving Advantages of Drug Combination in Osteosarcoma Treatment: Pt(II) and Pd(II) Complexes Application According to the EURAMOS-1 Protocol"	Diamond Light Source Ltd, United Kingdom
2022/04 - 2022/04	Experiment SM26320: "An Enhanced Insight of Cell Response to Anticancer Drugs by AFM-IR Nanospectroscopy"	Diamond Light Source Ltd, United Kingdom
2022/01 - 2022/01	Experiment SM29925: "SR-FTIR Microspectroscopy of Live Single Cells to Probe Anticancer Drug Action"	Diamond Light Source Ltd, United Kingdom
2019 - 2019	Experiment SM21620: "Probing Chemoresistance to Pt- and Pd-Drugs via THz Spectroscopy"	Diamond Light Source Ltd, United Kingdom
2018/10 - 2018/10	Experiment SM19692: "Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma"	Diamond Light Source Ltd, United Kingdom
2018/05 - 2018/05	Experiment SP18498: "An EXAFS Approach to the Pharmacodynamics of Unconventional Pt- and Pd-Based Anticancer Drugs"	Diamond Light Source Ltd, United Kingdom
2017/05 - 2017/05	Experiment SP16058: "An EXAFS Approach to the Pharmacodynamics of Unconventional Pt- and Pd-Based Anticancer Drugs"	Diamond Light Source Ltd, United Kingdom
2017/02 - 2017/02	Experiment SM14895: "Probing Polynuclear Cisplatin-like Agents Activity on DNA via Thz Spectroscopy	Diamond Light Source Ltd, United Kingdom
2016 - 2016	Experiment SM13726: "Infrared Signature of Drug Action at the Single Cell Level - Cisplatin-Like Agents. SR-FTIR Imaging via FPA on Human Breast Cancer Cells"	Diamond Light Source Ltd, United Kingdom
2015 - 2015	Experiment SM10065: "SR-IR Signature of Drug Action at Single Cell Level - Novel Cisplatin-like Agents"	Diamond Light Source Ltd, United Kingdom

Distinctions

Other distinction

2024	ISIS Highlight - How water dynamics could be a new cancer biomarker ISIS Pulsed Neutron and Muon Source, United Kingdom
2021	ISIS Highlight - Human Tissue Measured for the First Time using QENS ISIS Pulsed Neutron and Muon Source, United Kingdom
2020	ISIS Highlight - Intracellular water could help us distinguish between healthy and malignant cells ISIS Pulsed Neutron and Muon Source, United Kingdom
2019	ISIS Highlight - Anticancer Drug Impact on DNA: a Study by Neutron Spectroscopy Coupled with Synchrotron-based FTIR and EXAFS ISIS Pulsed Neutron and Muon Source, United Kingdom
2019	PCCP HOT Articles/Editor choice for themed collection 2019 - Anticancer Drug Impact on DNA: A Study by Neutron Spectroscopy coupled to Synchrotron-based FTIR and EXAFS
2019	ISIS Neutron & Muon Source Impact Award 2019 - Public Engagement & Society, "Shining the Beam on Cells category - Intracellular Water as a Mediator of Anticancer Drug Action" ISIS Pulsed Neutron and Muon Source, United Kingdom
2017	ISIS Highlight - Intracellular Water - an Overlooked Cancer Drug Target ISIS Pulsed Neutron and Muon Source, United Kingdom
2017	Diamond Highlight - Probing Polynuclear Cisplatin-like Agents Activity on DNA via THz Spectroscopy Diamond Light Source Ltd, United Kingdom