Inês Rodrigues Lopes (4517-A68E-1EA0)

Curriculum Vitae

Inês Rodrigues Lopes

Inês Rodrigues Lopes graduated in Biochemistry at the University of Coimbra in 2014 and obtained her MSc degree in Biochemistry in 2016 at the University of Porto. She completed her PhD in January 2024 within the PhD Programme in Experimental Biology and Biomedicine (PDBEB), at the Center for Innovative Biomedicine and Biotechnology (CIBB/CNC), University of Coimbra. Inês works in the fields of Microbiology and Cell Biology. Her studies focus on the virulence mechanisms and molecular processes operating in hosts infected with bacterial pathogens with high impact in human health, such as Staphylococcus aureus, Shigella flexneri, Salmonella Typhimurium, Escherichia coli and Group B Streptococcus. She has published six papers in peer-reviewed journals, including two as first author, mainly in the area of infectious diseases. Her PhD project established S. aureus intracellular lifestyle as a prevalent feature of S. aureus infection. Moreover, it identified S. aureus factors required for invasion, intracellular replication, persistence, and S. aureus-induced host cytotoxicity within host cells to define novel therapeutic approaches.

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Identification

Personal identification

Full name: Inês Rodrigues Lopes

Citation names

Rodrigues Lopes, Inês
Lopes, Inês Rodrigues

Author identifiers

Ciência ID: 4517-A68E-1EA0
ORCID iD: 0000-0003-1527-543X

Email addresses

ines.lopes13ns@gmail.com (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Microbiology
Natural sciences - Biological Sciences - Cell Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2019 - 2024 Concluded	Experimental Biology and Biomedicine (Doutoramento) Major in Biotecnologia e Saúde Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal "Staphylococcus aureus intracellular lifestyle: phenotypical profiles and underlying molecular determinants" (THESIS/DISSERTATION)
2014 - 2016 Concluded	Biochemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal "Exploring the immunobiological basis of prospective strategies towards two human neonatal pathogens: Group B Streptococcus and Escherichia coli" (THESIS/DISSERTATION)
2010 - 2014 Concluded	Biochemistry (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal "Chimeric studies: towards the non-invasive evaluation of renal grafts" (THESIS/DISSERTATION)

Affiliation

Science

	Category Host institution	Employer
2024/11 - Current	Postdoc (Research)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/08 - 2024/04	Researcher (Research)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2017/09 - 2018/12	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/08 - 2018/09	Visiting Researcher (Research)	Universidade de São Paulo Hospital das Clínicas, Brazil
	Universidade de São Paulo Hospital das Clínicas, Brazil
2017/01 - 2017/07	Research Trainee (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

	Category Host institution	Employer
2019/01 - 2024/01	PhD student Fellow	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/09 - 2016/12	Master student Fellow	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/01 - 2014/07	Bachelor student Fellow	Hospitais da Universidade de Coimbra Centro de Histocompatibilidade do Centro, Portugal
	Hospitais da Universidade de Coimbra Centro de Histocompatibilidade do Centro, Portugal

Projects

Grant

	Designation	Funders
2019/01 - 2024/01	Staphylococcus aureus intracellular lifestyle: phenotypical profiles and underlying molecular determinants PD/BD/146464/2019 PhD Student Fellow Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07 - 2022/12	Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains POCI-01-0145-FEDER-029999 Team member Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/09 - 2018/12	Intracellular Staphylococcus aureus: deciphering bacterial and cellular factors involved in host cell invasion by clinically relevant strains to define new therapeutic approaches (StaphIn) Infect-ERA/0001/2015 Research Fellow Centro de Inovação em Biomedicina e Biotecnologia, Portugal	European Commission Seventh Framework Programme for Research and Technological Development Health Concluded
2015/09 - 2016/12	Avaliação do impacto de uma nova vacina contra as doenças dos recém-nascidos causadas pelo estreptococos do grupo B na microbiota comensal POCI-01-0145-FEDER-016607 Master Student Fellow Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Fundação para a Ciência e a Tecnologia European Regional Development Fund Concluded

Outputs

Publications

Conference poster	Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. Corresponding author: Alcântara, Laura. "Functional high-throughput screening identifies microRNAs regulating Staphylococcus aureus intracellular lifestyle". Paper presented in RNA biology in host-pathogen interactions - Epiviral conference, 2024. Rodrigues Lopes, Inês; Alcantara, Laura Maria ; Silva, Ricardo Jorge; Josse, Jerome; Vega, Elena Pedrero ; Cabrerizo, Ana Marina ; Bonhomme, Melanie ; et al. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in EMBO\| EMBL Symposium: New Approaches and Concepts in Microbiology, 2023. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in XI ptRNA Meeting - RNA in Disease, 2023. Rodrigues Lopes, Inês; Silva, Ricardo Jorge; Josse, Jerome; Vega, Elena P. ; Bonhomme, Melanie ; Lopez, Daniel ; Laurent, Frederic; et al. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in BEB Day 2022- The Overview Effect, 2022. Rodrigues Lopes, Inês; Silva, Ricardo Jorge; Josse, Jerome ; Vega, Elena P. ; Bonhomme, Melanie ; Lopez, Daniel ; Laurent, Frederic; et al. Corresponding author: Eulalio, Ana. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in EMBO\| EMBL Symposium: New Approaches and Concepts in Microbiology, 2021. Cunha, Pedro; Morais, Catarina; Rodrigues Lopes, Inês; Mestre, Beatriz; Jurado, Amália S; Pedroso de Lima, Maria C. "Differentiation therapy toward glioblastoma stem-like cells". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018. Carvalho, Diana; Marques, Bruno ; Rodrigues Lopes, Inês; Simões, Olivia ; Gomes, José ; Gonçalves, Ana ; Mateus, Rosário; et al. "Potential molecular markers of chronic dysfunction in urine of kidney transplant patients". Paper presented in 29th European Immunogenetics and Histocompatibility Conference, 2015.
Journal article	Marta Ukleja; Lara Kricks; Gabriel Torrens; Ilaria Peschiera; Rodrigues Lopes, Inês; Marcin Krupka; Julia García-Fernández; et al. "Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains". Nature Communications 15 5583 (2024): https://doi.org/10.1038/s41467-024-49951-1. Published • 10.1038/s41467-024-49951-1 Rodrigues Lopes, Inês; Alcantara, Laura Maria ; Silva, Ricardo Jorge; Josse, Jerome ; Vega, Elena Pedrero ; Cabrerizo, Ana Marina ; Bonhomme, Melanie ; et al. Corresponding author: Eulalio, Ana. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Nature Communications 13 7174 (2022): https://doi.org/10.1038/s41467-022-34790-9. Published • 10.1038/s41467-022-34790-9 Aguilar, Carmen; Cruz, Ana Rita; Rodrigues Lopes, Ines; Maudet, Claire; Sunkavalli, Ushasree; Silva, Ricardo Jorge; Sharan, Malvika; et al. Corresponding author: Eulalio, Ana. "Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection". Nature Microbiology 5 1 (2019): 192-205. https://doi.org/10.1038/s41564-019-0614-3. Published • 10.1038/s41564-019-0614-3 Rodrigues Lopes, Ines; Silva, Ricardo Jorge; Caramelo, Ines; Eulalio, Ana; Mano, Miguel. Corresponding author: Mano, Miguel. "Shedding light on microRNA function via microscopy-based screening". Methods 152 (2019): 55-64. https://doi.org/10.1016/j.ymeth.2018.09.011. Published • 10.1016/j.ymeth.2018.09.011 Tawk, Caroline; Nigro, Giulia; Rodrigues Lopes, Ines; Aguilar, Carmen; Lisowski, Clivia; Mano, Miguel; Sansonetti, Philippe; Vogel, Jörg; Eulalio, Ana. Corresponding author: Eulalio, Ana. "Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens". The EMBO Journal 37 23 (2018): https://doi.org/10.15252/embj.201798529. Published • 10.15252/embj.201798529 Cunha, Pedro P; Costa, Pedro M; Morais, Catarina M; Rodrigues Lopes, Inês; Cardoso, Ana M; Cardoso, Ana L; Mano, Miguel; Jurado, Amália S; Pedroso de Lima, Maria C. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387. https://doi.org/10.1093/hmg/ddx323. Published • 10.1093/hmg/ddx323
Thesis / Dissertation	"Staphylococcus aureus intracellular lifestyle: phenotypical profiles and underlying molecular determinants". PhD, Universidade de Coimbra Instituto de Investigação Interdisciplinar, 2024. Lopes, Inês. "Exploring the immunobiological basis of prospective strategies towards two human neonatal pathogens: Group B Streptococcus and Escherichia coli". Master, Universidade do Porto Faculdade de Ciências, 2016.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/09	Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature	Innovative Therapies Retreat 2022 Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2022/02	Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature	High-Throughput Screening for Target and Drug Discovery Course (PDBEB) University of Coimbra (Coimbra, Portugal)
2021/09	Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature	Innovative Therapies Retreat 2021 Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2019/12	Interaction of Staphylococcus aureus with host cells: evaluation of the prevalence of the intracellular lifestyle	Microbiotec 19 Sociedade Portuguesa de Microbiologia, Sociedade Portuguesa de Biotecnologia (Coimbra, Portugal)
2016/02	Deciphering the innate immune response of neonates to the pathogen Escherichia coli	9th IJUP \| Investigação Jovem da Universidade do Porto Universidade do Porto (Porto, Portugal)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/12/09 - 2019/12/10	BEBDAY 2019 (2019/12/09 - 2019/12/10) Conference (Member of the Organising Committee)	Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/02/01 - 2021/02/05	High-Throughput Screening for Target and Drug Discovery Course Workshop	High-Throughput Screening for Target and Drug Discovery Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/04/01 - 2019/04/05	Host and Microbe Interactions II (Biology at the Host Microbe Interface PHD Program) Workshop	Host and Microbe Interactions II (Biology at the Host Microbe Interface PHD Program) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/03/18 - 2019/03/22	Fighting Infection Course (PDBEB) Workshop	Fighting Infection Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/14 - 2017/09/14	High Content Imaging and Complementary Techonologies Workshop	High Content Imaging and Complementary Techonologies PerkinElmer Inc, United States
2016/07/15 - 2016/07/15	GABBA Annual Symposium: Breaking Boundaries in Science Symposium	GABBA Annual Symposium: Breaking Boundaries in Science Universidade do Porto, Portugal
2014/03/24 - 2014/03/24	Células Estaminais: da investigação básica à aplicação terapêutica Workshop	Células Estaminais: da investigação básica à aplicação terapêutica Instituto Português do Sangue e da Transplantação IP, Portugal
2013/06/08 - 2013/06/08	2nd BEB Symposium: Seeding Curiosity, Harvesting Science Symposium	2nd BEB Symposium: Seeding Curiosity, Harvesting Science Centro de Inovação em Biomedicina e Biotecnologia, Portugal