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Maria João Castro Gouveia. Completed an integrated Master's degree in Chemistry on 11/2011/18 at the University of Porto Faculty of Sciences, PhD in Veterinary Sciences on 12/2019/12 at the University of Porto Institute of Biomedical Sciences Abel Salazar and Degree in Chemistry on 07/30/2009 from the University of Porto Faculty of Sciences. She is a Researcher at the University of Porto Institute of Agricultural and Agro-Food Sciences and Technologies. She published 25 articles in specialized journals. Shee co-supervised 2 work(s) completing a degree course in Biochemistry. She works in the area(s) of Medical and Health Sciences with an emphasis on Health Sciences with an emphasis on Parasitology, namely in the study of processes associated with cancer associated with parasitic infections and the development of new therapies for them. In your Ciência Vitae curriculum, the most frequent terms in the context of scientific production are: S. haematobium; Opisthorchis; Metabolites; schistosomiasis urogenital; bladder cancer ; cytoscopic; Schistosomiasis; Opisthorchiasis; helminth infections-associated cancer; parasitic metabolites; Antioxidants; combination therapy; drug repurposed; Helminth infections; carcinogenesis; DNA adducts; CYP enzymes; antioxidants; drug combination; drug repurposing; Helminth infection,; Malignancy, ; Schistosomiasis,; Opisthorchiasis; Cytochrome P450; Oxysterol; Schistosoma mansoni; antioxidant biomolecules; anthelmintic drug; anticancer drug; newly transformed schistosomula; Anthelmintic; Biomolecules; N-acetylcysteine; Resveratrol; Schistosomula; praziquantel; schistosomiasis; drug delivery; amino acid transport; in vitro and in vivo assays; prodrug design; stability studies; Schistosoma haematobium; bladder; estrogen-DNA adduct; estrogen-like metabolites; squamous cell carcinoma; urogenital schistosomiasis; cytochromes P450; enantiomers; metabolism; praziquantel;; Angola; Bladder; Catechol estrogen quinone; DNA adduct; Squamous cell carcinoma.
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Identification

Personal identification

Full name
Maria João de Castro Gouveia

Author identifiers

Ciência ID
461E-6C7C-BCD1

Websites

Education
Degree Classification
2021/07/12 - 2021/07/16
Concluded
 Medicinal Plants - Challenges and Opportunities (Outros)
Universidade do Porto Faculdade de Farmácia, Portugal
 19
2019/12/12
Concluded
 Veterinary Sciences (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Novel therapeutics approaches against Schistosoma haematobium and Opisthorchis viverrini and associated cancer (bladder cancer and cholangiocarcinoma)" (THESIS/DISSERTATION)
 Aprovado
2016/06/26
Concluded
 Curso de Formaçao em Cultura de Células (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
 17
2016/06/01
Concluded
 VII Workshop on Cancer Research: biological and molecular basis (Outros)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011/11/18
Concluded
 Chemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Development of new ITK inhibitors to combat HIV/AIDS" (THESIS/DISSERTATION)
2009/07/30
Concluded
 Chemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Outputs

Publications

Journal article
  1. Bárbara Costa; Maria Gouveia; Nuno Vale. "Safety and Efficacy of Antiviral Drugs and Vaccines in Pregnant Women: Insights from Physiologically Based Pharmacokinetic Modeling and Integration of Viral Infection Dynamics". Vaccines (2024): https://www.mdpi.com/2076-393X/12/7/782.
    10.3390/vaccines12070782
  2. Gouveia, Maria João; Ribeiro, Eduarda; Vale, Nuno. "A Surprising Repurposing of Central Nervous System Drugs against Squamous Cell Carcinoma of the Bladder, UM-UC-5". Pharmaceutics 16 2 (2024): 212. http://dx.doi.org/10.3390/pharmaceutics16020212.
    Published • 10.3390/pharmaceutics16020212
  3. da Costa, José Manuel Correia; Gouveia, Maria João; Rinaldi, Gabriel; Brindley, Paul J.; Santos, Júlio; Santos, Lúcio Lara. "Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.626672.
    Published • 10.3389/fcimb.2021.626672
  4. Mariana Pereira; Guy Caljon; Maria Gouveia; Louis Maes; Nuno Vale. "Synthesis, Biological Activity and In Silico Pharmacokinetic Prediction of a New 2-Thioxo-Imidazoldidin-4-One of Primaquine". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/3/196.
    10.3390/ph14030196
  5. Lúcio Lara Santos; Júlio Santos; Maria Gouveia; Carina Bernardo; Carlos Lopes; Gabriel Rinaldi; Paul J. Brindley; José M. Correia da Costa. "Urogenital Schistosomiasis—History, Pathogenesis, and Bladder Cancer". Journal of Clinical Medicine (2021): https://www.mdpi.com/2077-0383/10/2/205.
    10.3390/jcm10020205
  6. Vale, Nuno; Duarte, Diana; Silva, Sara; Correia, Ana Salomé; Costa, Bárbara; Gouveia, Maria João; Ferreira, Abigail. "Cell-penetrating peptides in oncologic pharmacotherapy: A review". Pharmacological Research 162 (2020): 105231. http://dx.doi.org/10.1016/j.phrs.2020.105231.
    Published • 10.1016/j.phrs.2020.105231
  7. Bernardo, Carina; Santos, Júlio; Costa, Céu; Tavares, Ana; Amaro, Teresina; Marques, Igor; Gouveia, Maria João; et al. "Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation". Urologic Oncology: Seminars and Original Investigations 38 9 (2020): 738.e23-738.e35. http://dx.doi.org/10.1016/j.urolonc.2020.04.022.
    Published • 10.1016/j.urolonc.2020.04.022
  8. Gouveia, Maria João; Brindley, Paul J.; Gärtner, Fátima; Vale, Nuno. "Activity of Combinations of Antioxidants and Anthelmintic Drugs against the Adult Stage of Schistosoma mansoni". Journal of Parasitology Research 2020 (2020): 1-9. http://dx.doi.org/10.1155/2020/8843808.
    Open access • Published • 10.1155/2020/8843808
  9. Vale, Nuno; Gouveia, Maria João; Gärtner, Fátima; Brindley, Paul J. "Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species". Parasitology Research 119 5 (2020): 1443-1453. http://dx.doi.org/10.1007/s00436-020-06640-4.
    Published • 10.1007/s00436-020-06640-4
  10. Vale, Nuno; Gouveia MJ; Gärtner, Fátima. "Current and Novel Therapies Against Helminthic Infections: The Potential of Antioxidants Combined with Drugs". Biomolecules 10 3 (2020): 350. http://dx.doi.org/10.3390/biom10030350.
    Published • http://dx.doi.org/10.3390/biom10030350
  11. Yang, Vítor; Gouveia, Maria João; Santos, Joana; Koksch, Beate; Amorim, Irina; Gärtner, Fátima; Vale, Nuno. "Breast cancer: insights in disease and influence of drug methotrexate". RSC Medicinal Chemistry 11 6 (2020): 646-664. http://dx.doi.org/10.1039/d0md00051e.
    Published • 10.1039/d0md00051e
  12. Gouveia, Maria João; Pakharukova, Maria Y.; Rinaldi, Gabriel; Mordvinov, Viatcheslav A.; Brindley, Paul J.; Gärtner, Fátima; Vale, Nuno. "Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola". Experimental Results 1 (2020): http://dx.doi.org/10.1017/exp.2020.38.
    Published • 10.1017/exp.2020.38
  13. Gouveia MJ; Brindley, Paul J.; Rinaldi, Gabriel; Gärtner, Fátima; da Costa, José M. C.; Vale, Nuno. "Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts". Infectious Agents and Cancer 14 1 (2019): http://dx.doi.org/10.1186/s13027-019-0257-2.
    Open access • Accepted • 10.1186/s13027-019-0257-2
  14. Gouveia MJ; Nogueira, Verónica; Araújo, Bruno; Gärtner, Fátima; Vale, Nuno. "Inhibition of the Formation In Vitro of Putatively Carcinogenic Metabolites Derived from S. haematobium and O. viverrini by Combination of Drugs with Antioxidants". Molecules 24 21 (2019): 3842. http://dx.doi.org/10.3390/molecules24213842.
    Open access • Accepted • 10.3390/molecules24213842
  15. Gouveia MJ; Brindley, Paul J.; Azevedo, Carlos; Gärtner, Fátima; da Costa, José M. C.; Vale, Nuno. "The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni". Parasites & Vectors 12 1 (2019): http://dx.doi.org/10.1186/s13071-019-3566-9.
    Open access • Accepted • 10.1186/s13071-019-3566-9
  16. Gouveia, Maria João; Brindley, Paul J.; Rinaldi, Gabriel; Gärtner, Fátima; da Costa, José Manuel Correia; Vale, Nuno. "Combination Anthelmintic/Antioxidant Activity Against Schistosoma Mansoni". Biomolecules 9 2 (2019): 54. http://dx.doi.org/10.3390/biom9020054.
    10.3390/biom9020054
  17. Vale, Nuno; Ferreira, Abigail; Matos, Joana; Fresco, Paula; Gouveia MJ. "Amino Acids in the Development of Prodrugs". Molecules 23 9 (2018): 2318. http://dx.doi.org/10.3390/molecules23092318.
    Open access • 10.3390/molecules23092318
  18. Gouveia MJ; Brindley, Paul; Gärtner, Fátima; Costa, José; Vale, Nuno. "Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules". Pharmaceuticals 11 1 (2018): 15. http://dx.doi.org/10.3390/ph11010015.
    Open access • 10.3390/ph11010015
  19. Gouveia MJ; Pakharukova, Maria Y; Laha, Thewarach; Sripa, Banchob; Maksimova, Galina A; Rinaldi, Gabriel; Brindley, Paul J; et al. "Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model". Carcinogenesis 38 9 (2017): 929-937. http://dx.doi.org/10.1093/carcin/bgx042.
    Published • 10.1093/carcin/bgx042
  20. Vale, Nuno; Gouveia MJ; Rinaldi, Gabriel; Brindley, Paul J.; Gärtner, Fátima; Correia da Costa, José M.. "Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance". Antimicrobial Agents and Chemotherapy 61 5 (2017): http://dx.doi.org/10.1128/aac.02582-16.
    Published • 10.1128/aac.02582-16
  21. Vale, Nuno; Gouveia MJ; Rinaldi, Gabriel; Santos, Júlio; Santos, Lúcio Lara; Brindley, Paul J; da Costa, José M Correia. "The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer". Tumor Biology 39 3 (2017): 101042831769224. http://dx.doi.org/10.1177/1010428317692247.
    Published • 10.1177/1010428317692247
  22. Gouveia MJ; Santos, Júlio; Brindley, Paul J.; Rinaldi, Gabriel; Lopes, Carlos; Santos, Lúcio L.; da Costa, José Manuel Correia; Vale, Nuno. "Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer". Cancer Letters 359 2 (2015): 226-232. http://dx.doi.org/10.1016/j.canlet.2015.01.018.
    Published • 10.1016/j.canlet.2015.01.018
  23. Correia da Costa, José M.; Vale, Nuno; Gouveia MJ; Botelho, MC; Sripa, Banchob; Santos, Lúcio L.; Santos, Júlio H.; Rinaldi, Gabriel; Brindley, Paul J.. "Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers". Frontiers in Genetics 5 (2014): http://dx.doi.org/10.3389/fgene.2014.00444.
    Published • 10.3389/fgene.2014.00444
  24. Santos, Júlio; Gouveia MJ; Vale, Nuno; Delgado, Maria de Lurdes; Gonçalves, Ana; da Silva, José M. Teixeira.; Oliveira, Cristiano; et al. "Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobium". PLoS ONE 9 5 (2014): e96774. http://dx.doi.org/10.1371/journal.pone.0096774.
    10.1371/journal.pone.0096774
  25. Vale, Nuno; Gouveia MJ; Botelho, Mónica; Sripa, Banchob; Suttiprapa, Sutas; Rinaldi, Gabriel; Gomes, Paula; Brindley, Paul J.; Correia da Costa, José Manuel. "Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC–MS/MS survey of soluble fraction parasite extract". Parasitology International 62 6 (2013): 535-542. http://dx.doi.org/10.1016/j.parint.2013.08.001.
    Published • 10.1016/j.parint.2013.08.001
  26. Gouveia MJ; Brindley, Paul J.; Santos, Lúcio Lara; Correia da Costa, José Manuel; Gomes, Paula; Vale, Nuno. "Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review". Metabolism 62 9 (2013): 1206-1217. http://dx.doi.org/10.1016/j.metabol.2013.04.003.
    10.1016/j.metabol.2013.04.003
  27. Botelho, Mónica C.; Vale, Nuno; Gouveia MJ; Rinaldi, Gabriel; Santos, Julio; Santos, Lucio L.; Gomes, Paula; Brindley, Paul J.; Correia da Costa, José Manuel. "Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen–DNA adducts mediated pathway?". International Journal for Parasitology 43 1 (2013): 17-26. http://dx.doi.org/10.1016/j.ijpara.2012.10.023.
    10.1016/j.ijpara.2012.10.023
Working paper
  1. Costa, Bárbara; Gouveia, Maria João; Vale, Nuno. Corresponding author: Vale, Nuno. 2024. "PBPK modeling of lamotrigine and efavirenz during pregnancy: implications for personalized dosing and drug-drug interactin management". https://www.mdpi.com/1999-4923/16/9/1163.
    10.3390/pharmaceutics16091163
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/29 "Production of parasitic recombinant proteins for combination therapy against schistosomiasis."
Associate Laboratory AL4Animals (Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/01/01 - Current Data-driven optimizations of antiviral therapy in pregant women: integrating physiological based pharmacokinetic analysis of antiviral drugs with viral infection dynamics.
Co-supervisor of Bárbara Lopes da Costa
 Doctoral Program in Data Science (PhD)
Universidade do Porto Faculdade de Medicina, Portugal

Centro de Investigação em Tecnologias e Serviços de Saúde, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2024/02/02 - 2024/07 Application of cell penetrating peptides Syn3 in reuse of drugs in oncology
Co-supervisor
 First degree in Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Centro de Saúde Pública Dr Gonçalves Ferreira - Instituto Nacional de Saúde Dr. Ricardo Jorge, Portugal
2024/02/01 - 2024/07 Combine treatment for schistosomiasis
Co-supervisor
 First Degree in Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Centro de Saúde Pública Dr Gonçalves Ferreira - Instituto Nacional de Saúde Dr. Ricardo Jorge, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/07/03 - 2024/07/05 Portuguese Science Summit occurred in Porto for another 3 days of this important meeting point for the scientific community. This year's motto was +Science for Health and global well-being. Our meeting had many moments of dialog, knowledge and conviviality.
Exhibition
Fundação para a Ciência e a Tecnologia, Portugal

Universidade do Porto, Portugal

Ciência Viva, Portugal
2023/04/12 - 2023/04/13 The first objective of this AL4AnimalS meeting was the dissemination and communication of the main results of the research carried out by members of this associated laboratory. The second objective was to increase the interrelationship between researchers from the three R&D units (CIISA, CECAV and CECA) that make up AL4AnimalS with a view to implementing future activity and new projects. A poster entitled " Combined therapy to treat schistosomiasis" (Gouveia MJ*, Castro A, Rinaldi G, Brindley PJ, Correia da Costa JM) was presented by me.
Meeting
Universidade de Trás-os-Montes e Alto Douro Centro de Ciência Animal e Veterinária, Portugal
2022/08/21 - 2022/08/26 15º Congresso Internacional de Parasitologia (ICOPA). Este congresso reuniu em Copenhaga, parasitologistas de todo mundo e de diversas áreas desta temática. Durante o evento foi apresentado um poster com o trabalho realizado. ICOPA XV
Danish Society of Parasitology, Denmark

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/10/27 Application of physiologically based pharmacokinetic modeling to predict drugdrug interaction between rocuronium/propofol/paracetamol and lidocaine
(Thesis) Main arguer
 Abigail Torres Silva (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2022/07/25 Estudo da eficácia de novos fármacos reaproveitados para potencial tratamento do cancro da mama
(Thesis) Main arguer
 Catarina Filipa de Sousa Moura (Other)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/01/12 - Current The discipline presented and discussed fundamental issues related to parasitology, especially helminths. Namely, life cycle, geographical distribution, control and prevention strategies, treatment, etc. Postgraduation in Clinical Analysis (Postgraduate Certificate) Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal