Daniel Freitas Chavarria (471E-8468-DEF7)

Curriculum Vitae

Daniel Freitas Chavarria

Daniel Chavarria obtained his BSc (2012) and MSc (2014) in Biochemistry from the Faculty of Sciences, University of Porto (FCUP, Portugal), and a PhD in Pharmaceutical Sciences (2020) from the Faculty of Pharmacy, University of Porto (FFUP, Portugal). His PhD was labeled as European Doctorate, and his PhD Thesis received an award of excellence from the Paul Ehrlich MedChem Euro-PhD in Medicinal Chemistry. During his PhD, Daniel developed projects in drug discovery at CIQUP-IMS/FCUP (Portugal), CNC-UC (Portugal), and UCIBIO (Portugal). Part of his PhD was performed at USC (Spain) under the supervision of Prof. Eugenio Uriarte. As a post-doc researcher, he also performed 2 secondments: one at Mediagnost GmbH (Germany), funded by project H2020-MSCA-RISE-2016-734719 and supervised by Dr Andrea Normann, and the other at the University of Montpellier (France), funded by project MitoTARGET4AD (2022.15117.CBM) and supervised by Prof Tangui Maurice. Daniel is currently a post-doc researcher at CIQUP-IMS. His current research interests fall within the area of CNS drug discovery. In particular, he aims to develop new drug candidates able to regulate pathophysiological processes associated with neurodegenerative diseases, namely chronic neuroinflammation, oxidative and nitrosative stress, mitochondrial dysfunction, ferroptosis, and neurotransmitter depletion. Daniel Chavarria was the principal investigator (PI) of project NOXIOUS (EXPL/BIA-BQM/0492/2021, 18 months, 50K). This exploratory project, focused on the development of targeted covalent inhibitors to unravel NOX2 crystal structure, counted with the collaboration of Prof. Andrea Mattevi (UniPV, Italy). He is also Co-PI of project DeFend (2022.04633.PTDC, 18 months, 50K), which aims at developing mitochondria-targeted iron chelators to treat Friedreich's Ataxia. Project DeFend is being performed in collaboration with Dr. António Currais (Salk institute, USA). Since the beginning of his scientific career, Daniel authored 32 peer-reviewed scientific publications in international high impact factor journals (12 as first author; 1 as corresponding author), some of which were published with collaborations from Italy, Spain, France, and Germany (h index ~12). He attended 18 national and international scientific meetings that resulted in 18 oral communications (7 as first author), 49 conference posters (16 as first author, 4 as last author), 3 conference abstracts, and 4 international scientific awards for best communications. He also attended 3 workshops and 2 training schools within the area of drug discovery and was actively involved in the organization of 4 international science dissemination activities (scientific meetings, workshops) and one course in Medicinal Chemistry. He was integrated in 20 research projects from national (FCT, NORTE2020) and European (FEDER) agencies. He is/was also the reviewer of research manuscripts (e.g.: RSC Medicinal Chemistry, Scientific Reports, Expert Opinion on Drug Discovery) and the guest editor of 2 special issues (Molecules). Finally, in addition to research, Daniel Chavarria is involved in teaching activities at FCUP, supervision/tutoring of national PhD (2), MSc (3) and BSc students (5), BSc/MSC fellows (2), mentoring of international Post-doc researchers (1), PhD (2) and MSc students (2), and in public exams of students (6).

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Identification

Personal identification

Full name: Daniel Freitas Chavarria

Citation names

Chavarria, Daniel

Author identifiers

Ciência ID: 471E-8468-DEF7
ORCID iD: 0000-0002-7010-9808
Scopus Author Id: 57189521654

Email addresses

danielfchavarria@gmail.com (Professional)
daniel.chavarria@fc.up.pt (Professional)

Addresses

Rua do Campo Alegre, s/n, 4169-007, Porto, Porto, Portugal (Professional)

Websites

https://drugdiscoveryup.pt/ (Professional)
https://www.researchgate.net/profile/Daniel-Chavarria-4 (Social media)
https://www.scopus.com/authid/detail.uri?authorId=57189521654 (Professional)

Knowledge fields

Exact Sciences - Chemical Sciences - Organic Chemistry
Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
Medical and Health Sciences - Basic Medicine - Toxicology
Natural sciences - Biological Sciences - Biochemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)

Education

	Degree	Classification
2015/09 - 2020/01/17 Concluded	PhD in Pharmaceutical Sciences (Doutoramento) Major in Toxicology Universidade do Porto Faculdade de Farmácia, Portugal "Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders" (THESIS/DISSERTATION)	Approved
2018/12/05 - 2018/12/07 Concluded	3rd MuTaLig Training School "CA15135 multi-targeting Biophysical Training School" (Outros) Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME Bereich Translationale Medizin Aussenstelle ScreeningPort, Germany
2017/05/02 - 2017/05/06 Concluded	37th Edition of the European School of Medicinal Chemistry (ESMEC) (Outros) Università degli Studi di Urbino Carlo Bo Dipartimento di Scienze Biomolecolari, Italy
2012/09 - 2014/09 Concluded	Biochemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Desenvolvimento de Novos Antioxidantes Lipofílicos como Solução Terapêutica para Doenças Neurodegenerativas" (THESIS/DISSERTATION)	18
2009/09 - 2012/09 Concluded	Biochemistry (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Synthesis of chromone amides: a contribution for the development of monoamine oxidase B (MAO-B) inhibitors" (THESIS/DISSERTATION)	16

Affiliation

Science

	Category Host institution	Employer
2020/03/16 - Current	Contracted Researcher (Research)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2023/11/19 - 2023/12/03	Visiting Researcher (Research)	Université de Montpellier, France

2022/04/01 - 2022/04/30	Visiting Researcher (Research)	Universidade do Porto Faculdade de Ciências, Portugal
	Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH, Germany
2018/07/02 - 2019/06/04	Visiting Researcher (Research)	Universidade de Santiago de Compostela, Spain

2011/10 - 2012/06	Research Trainee (Research)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal

Others

	Category Host institution	Employer
2015/09 - 2020/01/17	PhD student, FCT Grant SFRH/BD/108119/2015	Universidade do Porto Faculdade de Farmácia, Portugal

2015/03/01 - 2015/06/30	Research Grant, Project "Development of Functional Materials"	Universidade do Porto Centro de Investigação em Química, Portugal

Projects

Grant

	Designation	Funders
2025/01 - 2027/12	TARGET-MJD: New molecules harnessing targeted protein degradation for the treatment of Machado-Joseph disease HR24-00578 Researcher Universidade do Porto Centro de Investigação em Química, Portugal	Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa' Ongoing
2024/11 - 2026	TaxReCode: Improving taxol response through the manipulation of the cancer tubulin CI24-10034 Researcher Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa' Ongoing

Contract

	Designation	Funders
2021/01/01 - Current	Plurianual Funding of the Associated Laboratory Institute of Molecular Sciences LA/P/0056/2020 Researcher Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024 - 2027	IMPULSE: IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN 101132028 Researcher	European Commission
2024/10/07 - 2025/07/31	DMD4PD-Development of a disease-modifying drug for Parkinson’s Disease 0002D1C4C5 Researcher Universidade do Porto Faculdade de Ciências, Portugal
2023/03/01 - 2025/02/28	MitoTARGET4AD: Improving Nature for a Novel Disruptive Treatment for Alzheimer's Disease 2022.15117.CBM Researcher Universidade do Porto Faculdade de Ciências, Portugal Université de Montpellier, France	Fundação para a Ciência e a Tecnologia
2023/01 - 2024/06	DeFend: De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators 2022.04633.PTDC 2022.04633.PTDC Co-Principal Investigator (Co-PI) Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2023/12/31	CIQUP - Financiamento Plurianual da Unidade de I&D CIQUP - Centro de Investigação em Química da Universidade do Porto UIDB/00081/2020 Researcher Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia
2022/02/01 - 2023/07/31	NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 Principal investigator Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2022/07/01 - 2023/06/30	MitoBOOST v2.0 - A Proof of Concept for the Use of Mitochondria-Targeted Polyphenols to Treat Non-Alcoholic Fatty Liver Disease CENTRO-01-0145-FEDER-181226 Researcher Universidade de Coimbra, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Agência para a Competitividade e Inovação IP Concluded
2021/06/01 - 2023/05/31	PT-OPENSCREEN - NORTE-01-0145-FEDER-085468: Infraestrutura Nacional para a Química Biológica e Genética NORTE-01-0145-FEDER-085468 Researcher Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade do Minho, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Ongoing
2018/07/26 - 2022/07/25	ABFISH: Development of new antibiotics for aquaculture POCI-01-0145-FEDER-028397 Researcher Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07/26 - 2020/01/17	COMT4brain: Development of centrally-active and safe catechol O-methyltransferase inhibitors POCI-01-0145-FEDER-029164 PhD Student Fellow Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07/26 - 2020/01/17	SkinShield - Redox-active phytochemicals triggering mitochondrial hormesis: developing a new generation of cosmetic active ingredients PTDC/BIA-MOL/28607/2017 POCI-01-0145-FEDER-02860 PhD Student Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/04/01 - 2019/09/30	MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria PTDC/DTP-FTO/2433/2014 PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/06/01 - 2019/05/31	SAM: Sustainable Advanced Materials (SAM) Norte-01-0145-FEDER-000028 PhD Student Fellow	Fundação para a Ciência e a Tecnologia Concluded
2015/09/01 - 2018/02/28	TOX-OER - Learning Toxicology through Open Educational Resources 2015-1-ES01-KA203-015957 Colaboration Universidade do Porto Faculdade de Farmácia, Portugal	Erasmus Plus Concluded
2015/03/01 - 2015/06/30	Development of Functional Materials NORTE-07-0124-FEDER-000065 Master Student Fellow Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Tiago Silva; Chavarria, Daniel; Lisa Sequeira; Maria Fernanda Martins Borges. "Recycling vanillin into ferulic acid-based antioxidants". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. United Kingdom: Royal Society of Chemistry, 2015. Published
Conference abstract	Silva, Vera; Benfeito, Sofia; Lima, Carla; Chavarria, Daniel; Gonçalves, Tiago; Costa, Inês; Remião, Fernando; Borges, Fernanda; Silva, Renata. "3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson's disease". Paper presented in Revista Científica Internacional RevSALUS, Porto, 2023. Accepted Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Published Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Barreiro, Sandra; Cagide, Fernando; Silva, Catia; Teixeira, José; et al. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Published
Conference poster	Martins, Rita; Ferreira, Filipa; Chavarria, Daniel; Borges, Fernanda; Oliveira, Paulo Jorge; Teixeira, José; Pereira, Rosa M.L.N.. "MitoPA2 mitochondriotropic antioxidant potential in bovine oocyte maturation and fertilization: preliminary results". Paper presented in XIV Congresso Ibérico sobre Recursos Genéticos Animais, 2024. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Recent Advances in the Discovery of Isoform-Selective NOX Inhibitors". Paper presented in Encontro Ciência 2024, 2024. Lima, Carla; Soares, Letícia; Alves, Catarina; Chavarria, Daniel; Sequeira, Lisa; Cagide, Fernando; Borges, Fernanda; Benfeito, Sofia. "Getting around on Friedrich ataxia: development of new mitochondriotropic strategies". Paper presented in Encontro Ciência 2024, 2024. Lima, Carla; Alves, Catarina; Chavarria, Daniel; Sequeira, Lisa; Cagide, Fernando; Borges, Fernanda; Benfeito, Sofia. "De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators". Paper presented in XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Ceramella, Jessica; Iacopetta, Domenico; Mariconda, Annaluisa; D'amato, Assunta; Chavarria, Daniel; Procopio, Francesca; Ortuso, Francesco; et al. "New Au and Ag NHC complexes with N-Boc-protected proline as promising candidates for neurodegenerative diseases". Paper presented in XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Insights into the development of isoform-selective, non-interfering NOX inhibitors". Paper presented in XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Dias, Inês; Bon, Leo; Chavarria, Daniel; Borges, Fernanda; Chaves, Sílvia; Santos, Maria Amélia. "Exploring rivastigmine-indole hybrids with anti-neurodegenerative multitarget ability: biometal modulation and MAO inhibition". Paper presented in CQE Days 2024, 2024. Lima, Inês; Castelôa, Mariana; Chavarria, Daniel; Conde, Carlos; Pombinho, António; Borges, Fernanda. "High throughput screening of heterocyclic compounds to identify new spindle assembly checkpoint inhibitors". Paper presented in IJUP - Investigação Jovem da Universidade do Porto (17ª edição), 2024. Soares, Letícia; Lima, Carla; Chavarria, Daniel; Sequeira, Lisa; Alves, Catarina; Borges, Fernanda; Benfeito, Sofia. "Development of new iron chelators targeting mitochondia with potential application in Friedreich ataxia". Paper presented in IJUP - Investigação Jovem da Universidade do Porto (17ª edição), 2024. Dias, Inês; Bon, Leo; Emmanuel, Marlene; Vogt, Paul; Chavarria, Daniel; Borges, Fernanda; Guerreiro-Oliveira, Catarina; et al. "Novel Rivastigmine derivatives as promising multi-target compounds for potential treatment of Alzheimer's disease". Paper presented in AD/PD 2024 - International Conference on Alzheimer's and Parkinson's Diseases and related Neurological Disorders, 2024. Chavarria, Daniel; Barreiro, Sandra; Aguiar, Brandon; Carneiro, Aitor; Crucitti, David; Borges, Fernanda; Matos, Maria João. "Evaluation of Physicochemical features and biological activity of propargylamine-containing compounds for Parkinson's disease". Paper presented in International Symposium on Advances in Synthetic and Medicinal Chemistry, Zagreb, Croatia, 2023. Castelôa, Mariana; Lima, Carla; Benfeito, Sofia; Aguiar, Brandon; Soares, Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, Thessaloniki, Greece, 2023. Raffellini, Lorenzo; Chavarria, Daniel; Cirone, Italo; Borges, Fernanda; Manera, Clementina; Rapposelli, Simona. "Synthesis and evaluation of novel neuroprotective multitarget compounds based on urolithin scaffold". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, Thessaloniki, Greece, 2023. Barreiro, Sandra; Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Cagide, Fernando; Sequeira, Lisa; Teixeira, José; et al. "Nitrogen-based cationic carriers as a game changer in the development of mitochondriotropic antioxidants". Paper presented in MitoPorto - Mitochondrial physiology, redox biology, and genetics, 2023. Albuquerque, Bárbara; Benfeito, Sofia; Chavarria, Daniel; Serrão, Paula; Borges, Fernanda; Soares-da-Silva, Patrício. "Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors". Paper presented in XVI Encontro de Jovens Investigadores da UP (IJUP), 2023. Silva, Vera; Benfeito, Sofia; Lima, Carla; Chavarria, Daniel; Gonçalves, Tiago; Costa, Inês; Remião, Fernando; Borges, Fernanda; Silva, Renata. "3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson's disease". Paper presented in II TOXRUN International Congress 2023, 2023. Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022. Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Barreiro, Sandra; Cagide, Fernando; Silva, Catia; Teixeira, José; et al. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022. Procopio, Francesca; Catalano, Raffaella; Chavarria, Daniel; Benfeito, Sofia; Alcaro, Stefano; Borges, Fernanda; Ortuso, Francesco. "Non-Chiral Components of Bergamot Essential Oil: Identification of a Novel, Selective Human Monoamine Oxidase B Inhibitor". Paper presented in X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Silva, Vera; Benfeito, Sofia; Costa, Inês; Lima, Carla; Chavarria, Daniel; Remião, Fernando; Borges, Fernanda; Silva, Renata. "Evaluation of cytotoxic and neuroprotective profile of potential dual-acting ligands for the treatment of Parkinson's disease". Paper presented in X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Chavarria, Daniel; Borges, Anabela; Benfeito, Sofia; Fernandes, Carlos; Oliveira, Catarina; Ribeiro, Marta; Simões, Manuel; Borges, Fernanda; Cagide, Fernando. "Quaternary phosphonium conjugates: a new class of antimicrobial agents?". Paper presented in X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Chavarria, Daniel; Benfeito, Sofia; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; Remião, Fernando; Oliveira, Paulo; Borges, Fernanda. "Tackling dopamine depletion and oxidative stress with innovative caffeic acid derivatives". Paper presented in X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Arrighi, Francesca; Guglielmi, Paolo ; Chavarria, Daniel; Oliveira, Catarina; Pontecorvi, Virginia ; Granese, Arianna ; Berrino, Emanuela ; et al. "Design, synthesis and human monoamine oxidase inhibitory activity of 2-aroylbenzofuran-3-ol and 2-aroylbenzofuran derivatives: a new route towards hMAOs inhibition.". Paper presented in X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Soares, Pedro; Fernandes, Carlos; Sousa, Sérgio; Alfenim, Ana; Chavarria, Daniel; Cagide, Fernando; Borges, Fernanda. "Development of Innovative Multitarget Drugs for Amyotrophic lateral sclerosis by targeting neuroinflammation and modulating iron dysregulation (virtual Event)". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry, 2021. Catalano, Raffaella; Maruca, Annalisa; Rocca, Roberta; Borges, Fernanda; Benfeito, Sofia; Chavarria, Daniel; Alcaro, Stefano; Ortuso, Francesco. "Phytocompounds and their metabolites profiling, as promising multi-target agents for the treatment of Alzheimer's disease (virtual event)". Paper presented in Paul Ehrlich Virtual Meeting 2021, 2021. Salermo, A.; Albertini, C.; Atzeni, S.; Uliassi, F.S.G.; Massenzio, F.; Monti, B.; Chavarria, Daniel; et al. "Combining riluzole/dexpramipexole and rasagiline in new multi-target-directed ligands in the context of Amyotrophic Lateral Sclerosis". Paper presented in 13th Young Medicinal Chemist Virtual Symposium, 2021. Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Gil-Martins, Eva; Silva, Renata; Remião, Fernando; Borges, Fernanda. "Design and development of piperine derivatives acting as potent MAO-B inhibitors and mild P-gp inhibitors". Paper presented in 4th WG meeting – Final status of WG activities within the MuTaLig COST Action, 2020. Monjane, Sandra; Silva, Vera; Martins, Eva-Gil; Chavarria, Daniel; Borges, Fernanda; Silva, Renata; Fernandes, Carlos. "Descoberta de Novas Entidades Químicas como Potenciais Moduladores da Glicoproteína-P". Paper presented in XV CICLO DE CONFERÊNCIAS DO IUCS - 2019, Porto, Portugal, 2019. Monjane, Sandra; Silva, Vera; Martins, Eva-Gil; Chavarria, Daniel; Borges, Fernanda; Silva, Renata; Fernandes, Carlos. "Descoberta de Novas Entidades Químicas como Potenciais Moduladores da Glicoproteína-P". Paper presented in IV Congresso da Associação Portuguesa de Ciências Forenses, Porto, Portugal, 2019. Chavarria, Daniel; Fernandes, Carlos; Cagide, Fernando; Remião, Fernando; Oliveira, Paulo Jorge; Borges, Fernanda. "Searching for New Neuroprotective Agents: Design, Synthesis and Biological Evaluation of Piperine-derived Cationic Compounds". Paper presented in 26th Young Research Fellows Meeting (YRFM), Paris, France, 2019. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Silva, Tiago; Alcaro, Stefano; Borges, Fernanda. "Evaluation of benzopyrone pharmacophore features on MAO-B inhibition". Paper presented in 26th Young Research Fellows Meeting (YRFM), 2019. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Silva, Tiago; Alcaro, Stefano; Borges, Fernanda. "Design and Development of Dual -Target Ligands Based on Benzopyran for the Treatment of Parkinson’s Disease". Paper presented in 3rd Annual meeting - MuTaLig COST ACTION (CA15135), Valleta, Malta, 2018. Chavarria, Daniel; Fernandes, Carlos; Cagide, Fernando; Remião, Fernando; Oliveira, Paulo Jorge; Borges, Fernanda. "Development of piperine-based triphenylphosphonium conjugates as a therapeutic solution for Alzheimer’s disease". Paper presented in 3rd Annual meeting - MuTaLig COST ACTION (CA15135), 2018, Valletta, Malta, 2018. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Silva, Tiago; Alcaro, Stefano; Borges, Fernanda. "Mapping the Pharmacophore of Benzopyrone MAO-B Inhibitors". Paper presented in 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, 2018. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Development of Novel Phenolic and Thiophenolic Antioxidants based on Hydroxycinnamic Acid Scaffold". Paper presented in 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, 2018. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Hydroxycinnamic acid derivatives and sulfured analogues: from synthesis to antioxidant properties". Paper presented in 2nd WG meeting – Status of WG activities of the MuTaLig COST Action (CA15135), Tenerife, Spain, 2018. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Natural products in drug discovery: enhancing the antioxidant profile of hydroxycinnamic acids". Paper presented in EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint meeting, Porto, Portugal, 2017. Garrido, Emanuela P.J.; Cerqueira, Ana S.; Chavarria, Daniel; Silva, Tiago; Borges, Fernanda; Garrido, Jorge. "Microencapsulation as a strategy to improve the ADMET properties of bioactive caffeic acid derivatives". Paper presented in EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint meeting, Porto, Portugal, 2017. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Design, synthesis and neuroprotective properties of new hydroxycinnamic acid-based antioxidants". Paper presented in 7th meeting of Paul Ehrlich MedChem EuroPhD Network, Vienna, Austria, 2017. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Effect of the acid strength on the antioxidant profile of natural and synthetic antioxidants". Paper presented in 37th Edition of the European School of Medicinal Chemistry (ESMEC), Urbino, Italy, 2017. Silva, Tiago; Martins, Daniel; Sequeira, Lisa; Chavarria, Daniel; Garrido, Jorge; Borges, Fernanda. "Optimizing nature: development of novel antioxidants based on ferulic acid". Paper presented in 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept, Budapest, Hungary, 2016. Cagide, Fernando; Reis, Joana; Chavarria, Daniel; Vilar, Santiago; Hripcsak, George; Uriarte, Eugenio; Kachler, Sonja; Klotz, Karl-Norbert; Borges, Fernanda. "Design and development of novel and selective A3 adenosine receptor ligands based on chromone-2-carboxamide". Paper presented in 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept, Budapest, Hungary, 2016. Chavarria, Daniel; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Insights on the development of novel neuroprotective agents: a comparative study between ferulic acid and related sulfanyl derivatives". Paper presented in 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich's magic bullet concept, Budapest, Hungary, 2016. Chavarria, Daniel; Silva, Tiago; Garrido, E. Manuela; Garrido, Jorge; Borges, Fernanda. "Electrochemical and antioxidant activity of diene derivatives inspired on natural hydroxycinnamic acids". Paper presented in XX Meeting of the Portuguese Electrochemical Society (XXSNSPE), Braga, Portugal, 2015. Chavarria, Daniel; Silva, Tiago; Summavielle, Teresa; Borges, Fernanda. "Development of Novel Neuroprotective Antioxidants Inspired on Hydroxycinnamic Acid Scaffold". Paper presented in V Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Krakow, Poland, 2015. Cagide, Fernando; Gaspar, Alexandra; Chavarria, Daniel; Martins, Daniel; Magalhães e Silva, Diogo; Milhazes, Nuno; Vilar, Santiago; et al. "Development of new adenosine receptors ligands based on chromone scaffold: adventures in the design and optimization process". Paper presented in V Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Krakow, Poland., 2015. Chavarria, Daniel; Silva, Tiago; Summavielle, Teresa; Borges, Fernanda. "Neuroprotective Properties of Lipophilic Antioxidants Based on Hydroxycinnamic Acid Template". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho, Braga, Portugal., 2015. Gaspar, Alexandra; Cagide, Fernando; Reis, Joana; Chavarria, Daniel; Kachler, Sonja; Klotz, Karl-Norbert; Borges, Fernanda. "Development of A3 adenosine receptor ligands by an analogue-based approach". Paper presented in Young Research Fellows Meeting (YRFM), Paris, France, 2015. Chavarria, Daniel; Cagide, Fernando; Gaspar, Alexandra; Borges, Fernanda. "Microwave Organic Reactions Applied to the Synthesis of Novel Monoamine Oxidase Inhibitors". Paper presented in V Encontro de Jovens Investigadores da UP (IJUP), 2012.
Journal article	Dias, Inês; Bon, Leo; Banas`, Angelika; Chavarria, Daniel; Borges, Fernanda; Guerreiro-Oliveira, Catarina; Cardoso, Sandra M.; et al. "Exploiting the potential of rivastigmine-melatonin derivatives as multitarget metal-modulating drugs for neurodegenerative diseases". Journal of Inorganic Biochemistry 262 (2025): 112734. http://dx.doi.org/10.1016/j.jinorgbio.2024.112734. Published • 10.1016/j.jinorgbio.2024.112734 Benfeito, Sofia; Albuquerque, Bárbara; Sequeira, Lisa; Lima, Carla; Chavarria, Daniel; Serrão, Paula; Cagide, Fernando; Soares-da-Silva, Patrício; Borges, Fernanda. "Discovery of a Potent, Selective, and Blood-Brain Barrier Permeable Non-nitrocatechol Inhibitor of Catechol-O-methyltransferase". Journal of Medicinal Chemistry 64 20 (2024): 18384-18399. http://dx.doi.org/10.1021/acs.jmedchem.4c01682. Published • 10.1021/acs.jmedchem.4c01682 Amorim, Ricardo; Chavarria, Daniel; Soares, Pedro; Benfeito, Sofia; Cagide, Fernando; Teixeira, José; Oliveira, Paulo; Borges, Fernanda. "Decreasing the Burden of Non-Alcoholic Fatty Liver Disease: from Therapeutic Targets to Drug Discovery Opportunities". European Journal of Medicinal Chemistry (2024): Submitted Gil-Martins, Eva; Cagide-Fagín, Fernando; Martins, Daniel; Borer, Ana; Barbosa, Daniel José; Fernandes, Carlos; Chavarria, Daniel; et al. Corresponding author: Silva, Renata. "Mechanistic Insights into the Neurotoxicity of 2,5-Dimethoxyphenethylamines (2C) and Corresponding N-(2-methoxybenzyl)phenethylamine (NBOMe) Drugs". Journal of Xenobiotics 14 2 (2024): 772-797. http://dx.doi.org/10.3390/jox14020044. 10.3390/jox14020044 Sequeira, Lisa; Benfeito, Sofia; Fernandes, Carlos; Gaspar, Alexandra; Lima, Inês; Peixoto, Joana; Alves, Catarina; et al. Corresponding author: Chavarria, Daniel. "Drug development for Alzheimer’s and Parkinson’s disease: where do we go now?". Pharmaceutics 16 6 (2024): 708. Published • 10.20944/preprints202404.0437.v1 Albertini, Claudia; Petralla, Sabrina; Massenzio, Francesca; Monti, Barbara; Rizzardi, Nicola; Bergamini, Christian; Uliassi, Elisa; et al. "Targeting Lewy body dementia with neflamapimod-rasagiline hybrids". Archiv der Pharmazie 2024 (2024): e2300525. http://dx.doi.org/10.1002/ardp.202300525. Published • 10.1002/ardp.202300525 Giovannuzzi, Simone; Chavarria, Daniel; Provensi, Gustavo; Leri, Manuela; Bucciantini, Monica; Carradori, Simone; Bonardi, Alessandro; et al. "Dual inhibitors of brain carbonic anhydrases and monoamine oxidase B efficiently protect against amyloid-ß-induced neuronal toxicity, oxidative stress and mitochondrial dysfunction". Journal of Medicinal Chemistry (2024): Published • 10.1021/acs.jmedchem.4c00045 Martins, Daniel; Gil-Martins, Eva; Cagide, Fernando; Fonseca, Catarina; Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; et al. "Unraveling the In Vitro Toxicity Profile of Psychedelic 2C Phenethylamines and Their N-Benzylphenethylamine (NBOMe) Analogues". Pharmaceuticals 16 8 (2023): 1158. http://dx.doi.org/10.3390/ph16081158. Published • 10.3390/ph16081158 Vicente-Zurdo, David; Brunetti, Leonardo; Piemontese, Luca; Guedes, Beatriz; Cardoso, Sandra M.; Chavarria, Daniel; Borges, Fernanda; et al. "Rivastigmine-benzimidazole Hybrids as Promising Multitarget Metal-modulating Compounds for Potential Treatment of Neurodegenerative Diseases". International Journal of Molecular Sciences 24 9 (2023): 8312. Published • 10.3390/ijms24098312 Costa, Inês; Barbosa, Daniel José; Benfeito, Sofia; Silva, Vera; Chavarria, Daniel; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Molecular mechanisms of ferroptosis and their involvement in brain diseases". Pharmacology & Therapeutics 244 (2023): 108373. http://dx.doi.org/10.1016/j.pharmthera.2023.108373. Published • 10.1016/j.pharmthera.2023.108373 Chavarria, Daniel; Borges, Anabela; Benfeito, Sofia; Sequeira, Lisa; Ribeiro, Marta; Oliveira, Catarina; Borges, Fernanda; Simões, Manuel; Cagide, Fernando. "Phytochemicals and quaternary phosphonium ionic liquids: connecting the dots to develop a new class of antimicrobial agents". Journal of Advanced Research 54 (2023): 251-279. http://dx.doi.org/10.1016/j.jare.2023.02.004. Published • 10.1016/j.jare.2023.02.004 Soares, Pedro; Chavarria, Daniel; Silva, Catia; Silva, Filomena S.G.; Oliveira, Paulo J.; Borges, Fernanda. "Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities". Ageing Research Reviews 83 (2023): 101790. http://dx.doi.org/10.1016/j.arr.2022.101790. 10.1016/j.arr.2022.101790 Benfeito, Sofia; Chavarria, Daniel; Fernandes, Carlos; Barreiro, Sandra; Cagide, Fernando; Sequeira, Lisa; Teixeira, José; et al. "Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks". Journal of Medicinal Chemistry 66 3 (2023): 1835-1851. http://dx.doi.org/10.1021/acs.jmedchem.2c01630. 10.1021/acs.jmedchem.2c01630 Chavarria, Daniel; Benfeito, Sofia; Soares, Pedro; Lima, Carla; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; et al. Corresponding author: Borges, Fernanda. "Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor". European Journal of Medicinal Chemistry 243 (2022): 114740. http://dx.doi.org/10.1016/j.ejmech.2022.114740. 10.1016/j.ejmech.2022.114740 Albertini, Claudia; Salerno, Alessandra; Atzeni, Silvia; Uliassi, Elisa; Massenzio, Francesca; Maruca, Annalisa; Rocca, Roberta; et al. "Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis". ACS Chemical Neuroscience (2022): http://dx.doi.org/10.1021/acschemneuro.2c00261. 10.1021/acschemneuro.2c00261 Catalano, Raffaella; Procopio, Francesca; Chavarria, Daniel; Benfeito, Sofia; Alcaro, Stefano; Borges, Fernanda; Ortuso, Francesco. "Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases". Molecules 27 8 (2022): 2467. http://dx.doi.org/10.3390/molecules27082467. 10.3390/molecules27082467 Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Maruca, Annalisa; Rocca, Roberta; Gil Martins, Eva; Barreiro, Sandra; et al. "Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?". Journal of Medicinal Chemistry 64 15 (2021): 11169-11182. http://dx.doi.org/10.1021/acs.jmedchem.1c00510. 10.1021/acs.jmedchem.1c00510 Chavarria, Daniel; Da Silva, Ophelie Da; Benfeito, Sofia; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; et al. "Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases". Antioxidants 10 2 (2021): 329. http://dx.doi.org/10.3390/antiox10020329. 10.3390/antiox10020329 Chavarria, Daniel; Fernandes, Carlos; Aguiar, Brandon; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Oliveira, Paulo J.; Uriarte, Eugenio; Borges, Fernanda. "Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues". Molecules 24 23 (2019): 4405. http://dx.doi.org/10.3390/molecules24234405. Open access • Published • 10.3390/molecules24234405 Mesiti, Francesco; Chavarria, Daniel; Gaspar, Alexandra; Alcaro, Stefano; Borges, Fernanda. "The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease". European Journal of Medicinal Chemistry 181 (2019): 111572. http://dx.doi.org/10.1016/j.ejmech.2019.111572. Published • 10.1016/j.ejmech.2019.111572 Chavarria, Daniel; Fernandes, Carlos; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Oliveira, Paulo J.; Borges, Fernanda. "Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid". Organic & Biomolecular Chemistry 17 44 (2019): 9646-9654. http://dx.doi.org/10.1039/c9ob01875a. Published • 10.1039/c9ob01875a Teixeira, José; Chavarria, Daniel; Borges, Fernanda; Wojtczak, Lech; Wieckowski, Mariusz R.; Karkucinska-Wieckowska, Agnieszka; Oliveira, Paulo J.. "Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease". Current Medicinal Chemistry 26 19 (2019): 3376-3406. http://dx.doi.org/10.2174/0929867324666170529101810. Published • 10.2174/0929867324666170529101810 Chavarria, Daniel; Cagide, Fernando; Pinto, Miguel; Gomes, Lígia R.; Low, John N.; Borges, Fernanda. "Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation". Journal of Molecular Structure 1182 (2019): 298-307. http://dx.doi.org/10.1016/j.molstruc.2019.01.060. Published • 10.1016/j.molstrue.2010.01.060 Chavarria, D; Fernandes, C; Silva, V; Silva, C; Gil Martins, E; Soares, P; Silva, T; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry (2019): 10.1016/j.ejmech.2019.111770 Garrido, E. Manuela P.J.; Cerqueira, Ana S.; Chavarria, Daniel; Silva, Tiago; Borges, Fernanda; Garrido, Jorge M.P.J.. "Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-ß-cyclodextrin". Food Chemistry 254 (2018): 260-265. http://dx.doi.org/10.1016/j.foodchem.2018.02.007. 10.1016/j.foodchem.2018.02.007 Reis, Joana; Cagide, Fernando; Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Gaspar, Alexandra; Uriarte, Eugenio; et al. "Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors". Journal of Medicinal Chemistry 59 12 (2016): 5879-5893. http://dx.doi.org/10.1021/acs.jmedchem.6b00527. Published • 10.1021/acs.jmedchem.6b00527 Chavarria, Daniel. "Discovery of the first A1 adenosine receptor ligand based on chromone scaffold". RSC Advances (2016): 10.1039/c6ra02347a Chavarria, Daniel; Silva, Tiago; Magalhães e Silva, Diogo; Remião, Fernando; Borges, Fernanda. "Lessons from black pepper: piperine and derivatives thereof". Expert Opinion on Therapeutic Patents 26 2 (2015): 245-264. http://dx.doi.org/10.1517/13543776.2016.1118057. Published • 10.1517/13543776.2016.1118057 Cagide, F; Gaspar, A; Reis, J; Chavarria, Daniel; Vilar, S; Hripcsak, G; Uriarte, E; et al. "Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands". RSC Advances (2015): 10.1039/C5RA14988F Gomes, Ligia R.; Low, John Nicolson; Cagide, Fernando; Chavarria, Daniel; Borges, Fernanda. "New insights in the discovery of novel h-MAO-B inhibitors: structural characterization of a series of N-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives". Acta Crystallographica Section E 71 5 (2015): 547-554. http://dx.doi.org/10.1107/s2056989015007859. Published • 10.1107/S2056989015007859 Chavarria, Daniel; Silva, Tiago; Martins, Daniel; Bravo, Joana; Summavielle, Teresa; Garrido, Jorge; Borges, Fernanda. "Exploring the cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants". MedChemComm 6 6 (2015): 1043-1053. http://dx.doi.org/10.1039/c5md00018a. Published • 10.1039/C5MD00018A Soares, Pedro; Fernandes, Carlos; Chavarria, Daniel; Borges, Fernanda. "Microwave-Assisted Synthesis of 5-Phenyl-2-hydroxyacetophenone Derivatives by a Green Suzuki Coupling Reaction". Journal of Chemical Education 92 3 (2014): 575-578. http://dx.doi.org/10.1021/ed400498w. 10.1021/ed400498w
Thesis / Dissertation	Chavarria, Daniel. "Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders". PhD, Universidade do Porto Faculdade de Farmácia, 2020. Chavarria, Daniel. "Desenvolvimento de Novos Antioxidantes Lipofílicos como Solução Terapêutica para Doenças Neurodegenerativas". Master, Universidade do Porto Faculdade de Ciências, 2014. https://repositorio-aberto.up.pt/handle/10216/82718.

Intellectual property

Provisional application for patent

2024. "Novel catechol-O-methyltransferase inhibitors, methods for preparation and use thereof".
Protected

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/06/17	Design, Synthesis and human monoamine oxidase inhibitory activity of 2-aroylbenzofuran derivatives: a new route towards hMAOs inhibition	XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION Sapienza university of Rome (Rome, Italy)
2024/04/24	Propargylamine-containing compounds for neurodegenerative diseases: biological activity, physicochemical properties and docking studies	4th MMCS: Harnessing the Power of New Drug Modalities (Barcelona, Spain)
2024/02/07	Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors	54th Meeting of the Portuguese Society of Pharmacology NOVA Medical School (Lisbon, Portugal)
2022/07/04	Brick by brick: pharmacophore mapping of chromone-based MAO-B inhibitors	29th Young Research Fellows Meeting, Nantes, France. Nantes Université (Nantes, France)
2021/12/09	New Potential MAO-B/p38 MAPK Dual Inhibitors Targeting Neuroinflammation in Alzheimer's Disease. (Virtual event)	2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity Università di Bologna (Italy)
2021/10/07	Tackling antimicrobial resistance with novel phytochemical-based conjugates: a structure-activity-toxicity study.	E-Conference on Innovation in Microbial Control (Porto, Portugal)
2021/07/26	Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders	Paul Ehrlich Virtual Meeting Università degli Studi "Magna Graecia" di Catanzaro (Catanzaro, Italy)
2021/07/26	Mapping chromone-3-phenylcarboxamide pharmacophore: quid est veritas?	Paul Ehrlich Virtual Meeting 2021 Università degli Studi "Magna Graecia" di Catanzaro (Catanzaro, Italy)
2020/03/05	Mapping the benzopyran chromone-3-carboxamide pharmacophore: structure-activity-toxicity and efflux transport studies	4th WG meeting - Final status of WG activities within the MuTaLig COST Action Faculty of Pharmacy, Ege University (Izmir, Turkey)
2020/02/22	Synthesis and structure-activity relationship study of piperine derivatives with MAO-B and P-gp inhibitory activities	II Workshop meeting CIQUP Faculty of Sciences, University of Porto (Porto, Portugal)
2019/06/13	Lessons from black pepper: moving from one to multitarget-directed ligands by diversity-oriented synthesis	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action meeting University "Magna Græcia" of Catanzaro (Catanzaro, Italy)
2019/06/13	Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action meeting Università degli Studi "Magna Graecia" di Catanzaro (Catanzaro, Italy)
2019/02/23	Development of Dual-Target Agents Based on Piperine Scaffold	3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action (CA15135) University of Paris Descartes (Paris, France)
2019/02/23	Design and development of new chemical entities for the treatment of Parkinson disease	3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action (CA15135) Faculté de Pharmacie de Paris, Université Paris DESCARTES (Paris, France)
2015/07/02	Antioxidants: from Nature to drug prototypes.	International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress Sapienza University of Rome (Roma, Italy)
2015/05/13	Exploring Cinnamic Acid Scaffold: Development of Promising Neuroprotective Lipophilic Antioxidants	VIII Encontro de Jovens Investigadores da UP (IJUP) Universidade do Porto (Porto, Portugal)
2015/03/27	Finding a therapeutic solution for neurodegenerative diseases: design and synthesis of novel neuroprotective agents	III ENEQUI – “Ilumina o teu conhecimento! Sociedade Portuguesa de Química (Aveiro, Portugal)
2014/06/04	Biology-oriented development of lipophilic antioxidants with neuroprotective activity	8th International Conference on Polyphenols Applications – ISANH Polyphenols 2014 International Society of Antioxidants in Nutrition and Health (ISANH) (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/04/03 - Current	De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators Co-supervisor	Química (PhD) Universidade do Porto Faculdade de Ciências, Portugal
2022/10/01 - Current	Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases? Supervisor	Química (PhD) Universidade do Porto Faculdade de Ciências, Portugal
2023/09 - 2024/11/19	Desenvolvimento de novos quelantes de ferro direcionados à mitocôndria com potencial aplicação da Ataxia de Friedreich Co-supervisor	Bioquímica (Master) Universidade do Porto Faculdade de Ciências, Portugal
2024/02/19 - 2024/07/27	Desenvolvimento de inibidores da NOX2 para regulação da neuroinflamação crónica em doenças neurodegenerativas Supervisor	Bioquímica (Other) Universidade do Porto Faculdade de Ciências, Portugal
2023/09 - 2024/07	Synthesis and evaluation of novel Spindle Assembly Checkpoint inhibitors Supervisor	Bioquímica (Master) Universidade do Porto Faculdade de Ciências, Portugal
2023/02/17 - 2023/07/04	Desenvolvimento de novos inibidores da NOX2 baseados na estrutura do VAS2870 Supervisor	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2022/10 - 2023/02	NOX2 como alvo terapêutico para desenvolvimento de novos fármacos para as doenças neurodegenerativas Supervisor	Bioquímica Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/02/15 - 2021/07/31	Development of selective NOX2 inhibitors Supervisor	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - 2020/07	Evaluation of drug-like properties of innovative multitarget-directed ligands for treatment of Parkinson's disease Co-supervisor	Bioengenharia (Master) Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/04 - 2016/07	Desenvolvimento de novos antioxidantes tendo como base modelos naturais Co-supervisor	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/06/26 - 2023/07/12	Co-organizer/Trainer of the international course "Drug Discovery 2030: A Roadmap for a New Decade". This course aimed to improve, via virtual classes and a week of intensive training, the participants skills in Medicinal Chemistry and Chemistry Biology. This course was funded with support from the European Commission and implemented within the framework of Blended Intensive Programmes (BIPs), a new format of Erasmus+ mobility. https://drugdiscovery2030.pt/ (2023/06/26 - 2023/07/12) Other (Co-organisor)	Universidade do Porto Faculdade de Ciências, Portugal
2021/05/07 - 2021/05/21	Co-organizer of the "First Webinar on Medicinal Chemistry". Three-day webinar (May 7th, 14th and 21st) organized within the framework of the Medicinal Chemistry curricular unit and opened to the scientific community. The webinar was aimed to bring together renowned researchers from academy and industry that exchanged and shared their experiences on aspects of Drug Discovery and Development. (2021/05/07 - 2021/05/21) Workshop (Co-organisor)	Universidade do Porto Faculdade de Ciências, Portugal
2018/06/12 - 2018/06/14	Member of the Local Organizing Committee during the "8th meeting of Paul Ehrlich MedChem EuroPhD Network" (2018/06/12 - 2018/06/14) Congress (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal
2017/09/22 - 2017/09/24	Member of the Local Organizing Committee during the "EpiChemBio and MuTaLig COST actions joint meeting" (2017/09/22 - 2017/09/24) Congress (Member of the Organising Committee)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2016/06/29 - 2016/07/01	Member of the Local Organizing Committee during the "10th World Congress on Polyphenols Applications" (2016/06/29 - 2016/07/01) Congress (Member of the Organising Committee)	Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/05/08 - 2024/05/10	IJUP - Investigação Jovem da Universidade do Porto (17ª edição) Conference	IJUP - Investigação Jovem da Universidade do Porto (17ª edição) Universidade do Porto, Portugal
2022/11/16 - 2022/11/18	XXVI Encontro Galego-Portugués de Química Conference	Universidade de Santiago de Compostela Facultade de Química, Spain
2022/10/17 - 2022/10/17	How to protect a research result via patent and how to accommodate this protection in the proposal budget for funding Workshop	UPTEC Associação de Transferência de Tecnologia da Asprela, Portugal
2022/06/14 - 2022/06/16	X Meeting of the Paul Ehrlich Euro-PhD Network Conference	Universitat Ramon Llull IQS, Spain
2021/10/07 - 2021/10/08	E-Conference on Innovation in Microbial Control Conference	Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2021/07/26 - 2021/07/28	Paul Ehrlich Virtual Meeting 2021 Conference	Università degli Studi Magna Graecia di Catanzaro, Italy
2020/12/01 - 2020/12/01	Webinar "Back to basics: Fundamental concepts of HPLC and UHPLC" (1 h). Organisation's name: VWR (part of Avantor). Other
2020/07/16 - 2020/07/16	Webinar "Improving cell-based assays and their future in drug discovery" (1h). Organisation's name: ICBAS/FFUP library, University of Porto, Portugal Other
2020/03/05 - 2020/03/06	4th WG meeting - Final status of WG activities within the MuTaLig COST Action (CA15135) Conference	Ege Üniversitesi Eczacilik Fakültesi, Turkey
2020/02/22 - 2020/02/22	II workshop meeting CIQUP Conference	Universidade do Porto Faculdade de Ciências, Portugal
2019/06/13 - 2019/06/15	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action meeting Conference	Università degli Studi Magna Graecia di Catanzaro, Italy
2019/02/23 - 2019/02/24	3rd WG meeting - Activities of young investigators within the WG MuTaLig COST Action (CA15135) Conference	Université de Paris UFR de Pharmacie, France
2019/02/20 - 2019/02/22	26th Young Research Fellows Meeting (YRFM) Conference	Université de Paris UFR de Pharmacie, France
2018/10/18 - 2018/10/19	3rd Annual meeting - MuTaLig COST ACTION (CA15135) Conference	University of Malta, Malta
2018/07/12 - 2018/07/14	8th meeting of Paul Ehrlich MedChem EuroPhD Network Conference	Universidade do Porto Faculdade de Ciências, Portugal
2018/03/15 - 2018/03/16	2nd WG meeting - Status of WG activities of the MuTaLig COST Action (CA15135) Conference	Universidad de La Laguna, Spain
2018/02/16 - 2018/02/20	"Project TOX-OER (Learning Toxicology through Open Educational Resources)". This project was funded with support from the European Commission and implemented in the framework of Erasmus+ programme under the Action KA2 -Cooperation for Innovation and the Exchange of Good Practices Strategic Partnerships for Higher Education-. Main activity: Preparation of contents in Portuguese for the "Module 7.1.: Patents and Patent Application" (http://moodle.toxoer.com/) Other	Project TOX-OER (Learning Toxicology through Open Educational Resources) Universidade do Porto Faculdade de Farmácia, Portugal
2017/11/27 - 2017/11/27	Participation in seminar (4 h). Dissemination of the Toxicology course MOOC (Massive Open Online Course). This initiative was promoted within the scope of the project Erasmus+ TOX-OER - Learning Toxicology through Open Educational Resources. Seminar	Dissemination of the Toxicology course MOOC (Massive Open Online Course) Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/22 - 2017/09/24	EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint meeting Conference	Universidade do Porto Faculdade de Ciências, Portugal
2017/08/25 - 2017/08/27	7th meeting of Paul Ehrlich MedChem EuroPhD Network Conference	Technischen Universität Wien, Austria
2016/11/18 - 2016/11/20	6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept Conference	Semmelweis Egyetem, Hungary
2016/05/18 - 2016/05/18	Participation in training initiative (4 h). Other	Introdução à escrita de um artigo científico: artigo original e artigo de revisão Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2016/04/27 - 2016/04/27	Participation in training initiative (4 h). Other	Introdução ao EndNote X7: da criação de uma biblioteca à escrita de um documento Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2016/03/16 - 2016/03/16	Participation in training initiative (4 h). Other	Web of Science e Scopus: pesquisa em bases de dados de citações Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2015/07/03 - 2015/07/05	V Meeting of the Paul Ehrlich MedChem Euro-PhD Network Conference	Uniwersytet Jagiellonski w Krakowie, Poland
2015/05/13 - 2015/05/15	VIII Encontro de Jovens Investigadores da UP (IJUP) Conference	Universidade do Porto, Portugal
2014/05/30 - 2014/05/30	Participation in workshop (1 day) Workshop	3rd workshop on Medicinal Chemistry - Drug Design and Development: Understanding the R&D Process Universidade do Porto Faculdade de Ciências, Portugal
2013/10 - 2014/01	Participation in english course (30 h) Other	English course, Level B2.1 (Vantage) Universidade do Porto Faculdade de Ciências, Portugal
2013/03/22 - 2013/03/24	Participation in meeting (3 days) Meeting	VI ENEBIOQ - Encontro Nacional de Estudantes de Bioquímica Universidade de Aveiro, Portugal
2012/02/17 - 2012/02/19	V Encontro de Jovens Investigadores da UP (IJUP) Conference	Universidade do Porto, Portugal
2011/09/08 - 2011/09/09	Participation in workshop (2 days) Workshop	New-indigo workshop - Antitumour and antiparasitic drugs Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/09/09	Development of predicted N(2)-alkylated oxotriazioindole ((R)-OTI) aldose reductase inhibitors for improved OTI drug like bioavailability (Thesis) Main arguer	Bruno Rangel da Silva Mansano (Other) Universidade do Porto Faculdade de Ciências, Portugal
2024/07/27	Bona fide NOX2 inhibition: a promising strategy for the development of new neuroprotective agents Supervisor	Bárbara Jayet Ribeiro (Other) Universidade do Porto Faculdade de Ciências, Portugal
2023/07/27	Desenvolvimento de novos inibidores da NOX2 baseados na estrutura do VAS2870 Supervisor	Vera Lúcia Pinheiro Amaral (Other) Universidade do Porto Faculdade de Ciências, Portugal
2023/07/21	Desenvolvimento de novas estratégias para o tratamento da resistência a antibióticos (Thesis) Main arguer	Joana Parreira Quadros Ferreira (Other) Universidade do Porto Faculdade de Ciências, Portugal
2023/02/17	NOX2 como alvo terapêutico para desenvolvimento de novos fármacos para as doenças neurodegenerativas Supervisor	Andreia Ferreira (Other) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2021/11/15	In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer (Thesis) Main arguer	Mariana Antunes Castelôa (Master) Universidade do Porto Faculdade de Ciências, Portugal
2021/07/13	Development of selective NOX2 inhibitors Supervisor	Inês Filipa Cabral Real Libânio (Other) Universidade do Porto Faculdade de Ciências, Portugal
2020/07/22	Design and development of cationic nanoparticles for the delivery of a catechol O-methyltransferase inhibitor to the brain (Thesis) Main arguer	Rúben Faria Correia (Other) Universidade do Porto Faculdade de Ciências, Portugal

Conference scientific committee

	Conference name	Conference host
2024/05/08 - 2024/05/10	IJUP2024 - Investigação Jovem na Universidade do Porto (Representative for Chemistry)	University of Porto

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022/09 - Current	Thesis (Q702)	Química (Doutoramento)	Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - Current	Invited professor of Medicinal Chemistry	Biochemistry (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal
2023/09 - 2024/09	Dissertation (BQ5001)	Bioquímica (Mestrado integrado)	Universidade do Porto Faculdade de Ciências, Portugal
2024/02/17 - 2024/07/27	Project/internship (BIOQ3003)	Bioquímica	Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07	Project/Internship (Q208)	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2021/02 - 2021/07	Project/Internship (Q208)	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2024/10/30	FCUP in a project to improve breast cancer treatment with Taxol	Notícias U.Porto and FCUP
2024/10/17	Three projects from FCUP highlighted on BIP PROOF 2024/25	Notícias U.Porto and FCUP
2023/04/04	Portuguese researchers develop antioxidant to fight neurodegenerative diseases	SIC Notícias
2023/04/04	FCUP develops antioxidant with potential to fight neurodegenerative diseases	Jornal de Notícias
2023/04/04	Newly developed antioxidant with potential to fight neurodegenerative diseases	Diário de Notícias
2023/04/04	Portuguese researchers develop antioxidant with potential to fight neurodegenerative diseases	CNN Portugal
2023/04/04	How Lego Chemistry can help to fight neurodegenerative diseases	Notícias U.Porto and FCUP

Journal scientific committee

	Journal title (ISSN)	Publisher
2022/09/15 - 2023/05/31	Molecules, "Advances in Drug Discovery Research in Europe"; https://www.mdpi.com/journal/molecules/special_issues/2PSM2TE9VP	MDPI AG
2020/07/07 - 2021/01/31	Molecules, "Recent Advances in CNS Drug Discovery"; https://www.mdpi.com/journal/molecules/special_issues/CNS_Drug	MDPI AG

Mentoring / Tutoring

	Topic	Student name
2024/03 - Current	De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators. MSc Fellowship. Project DEFEND:De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators” (2022.04633.PTDC). Role: Co-supervisor	Catarina Alves
2024/09/01 - 2025/02/28	Use of scaffold-hopping to obtain new heterocyclic chalcone mimetics to develop compounds with anti-prion activity. International Mobility. Role: Supervisor.	Lucas Caruso (PhD in Chemistry, Federal Rural University of Rio de Janeiro, Brazil)
2024/02 - 2024/07	Desenvolvimento de novas moléculas para o tratamento de doenças associadas o stress oxidativo	Teresa Baptista Rocha
2023/04/12 - 2023/12/21	In vitro evaluation of bioactivity (antioxidant, enzyme inhibition) of plant extracts. Role: mentor	Jessica Ceramella (Post doc researcher, University of Calabria, Italy)
2023/03/01 - 2023/06/02	Enzymatic assays for the evaluation of the activity of acetylcholinesterase and monoamine oxidase B inhibitors. International mobility of PhD student. Role: Supervisor	Michele Collucia (PhD in Pharmaceutical Sciences, University of Rome, Italy)
2022/10/15 - 2023/05/14	Design and synthesis of new chemical entities based on VAS2870. BSc fellowship. Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021) (7 months). Role: supervisor	Carla Patrícia Costa Lima
2022/10/06 - 2023/02/02	Insights into the discovery of new neuroprotective agents. International mobility of MSc under the ERASMUS+ programme. Role: Mentor	Sara Bertolami (MSc in Pharmaceutical Chemistry and Technology, University of Pisa, Italy)
2022/05/01 - 2022/09/30	Tailoring VAS27870 scaffold to develop new covalent NOX2 inhibitors. MSc fellowship (5 months). Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021). Role: Supervisor	Mariana Antunes Castelôa
2020/02/20 - 2020/04/20	Synthesis and biological evaluation of urolithin derivatives for neurodegenerative diseases. International mobility of MSc under the ERASMUS+ programme. Role: Mentor	Giulia Fusi (MSc in Pharmaceutical Chemistry and Technology, University of Pisa, Italy)

Other jury / evaluation

	Activity description	Institution / Organization
2024/08/08 - Current	Member of the selection committee for the attribution of one research grant (Master’s degree) under the project UIDB/00081/2020-RG1. Role: 2nd alternate member.	Universidade do Porto Faculdade de Ciências, Portugal
2024/04/01 - Current	Member of the selection committee for the attribution of one research grant (Master’s degree) under the project UIDB/00081/2020-RG1. Role: 1st effective member.	Universidade do Porto Faculdade de Ciências, Portugal
2024/03/13 - Current	Member of the selection committee for the attribution of one research grant (Master’s degree) under the project DeFend: De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators” (2022.04633.PTDC). Role: 2nd effective member.	Universidade do Porto Faculdade de Ciências, Portugal
2022/08/28 - Current	Member of the selection committee for the attribution of one research grant (Bachelor’s degree) under the project “NOXIOUS – Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure” (EXPL/BIA-BQM/0492/2021). Role: President.	Universidade do Porto Faculdade de Ciências, Portugal
2022/03/24 - Current	Member of the selection committee for the attribution of one Master research grant (Master’s degree) under the project “NOXIOUS – Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure” (EXPL/BIA-BQM/0492/2021). Role: President.	Universidade do Porto Faculdade de Ciências, Portugal

Distinctions

Award

2024	Best article Prize (Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier) in IACOBUS-Papers cross-border scientific collaboration between the northern reg Xunta de Galicia, Spain
2022	Award for best poster presentation (X Meeting of the Paul Ehrlich Euro-PhD Network, 2022, July 14-16th, Barcelona, Spain) Universitat Ramon Llull IQS, Spain
2020	Award for 2nd best poster presentation (4th WG meeting - Final status of WG activities within the MuTaLig COST Action (CA15135), 2020, March 5th-6th, Izmir, Turkey) Ege Üniversitesi Izmir Arastirma ve Uygulama Merkezi, Turkey
2020	Best award for oral presentation (4th WG meeting - Final status of WG activities within the MuTaLig COST Action (CA15135), 2020, March 5th-6th, Izmir, Turkey) Ege Üniversitesi Izmir Arastirma ve Uygulama Merkezi, Turkey

Title

2021	Award of excellence from the Paul Ehrlich MedChem Euro-PhD in Medicinal Chemistry Università degli Studi Magna Graecia di Catanzaro, Italy
2020	European Doctorate Universidade do Porto Faculdade de Farmácia, Portugal

Other distinction

2022	Mobility grant, funded by project H2020-MSCA-RISE-2016-734719 European Commission Directorate-General for Research and Innovation, Belgium
2020	Conference grant to attend the 4th WG meeting - Final status of WG activities within the MuTaLig COST Action European Cooperation in Science and Technology, Belgium
2019	Conference Grant for Early Career Investigators (ECI) and PhD students from Inclusiveness Target Countries (ITC) European Cooperation in Science and Technology, Belgium
2018	Full grant, CA15135 Multi-Targeting Biophysical Training School, 2nd edition (EU) European Cooperation in Science and Technology, Belgium
2018	Conference grant to attend the 2nd WG meeting - Status of WG activities of the MuTaLig COST Action (CA15135) European Cooperation in Science and Technology, Belgium