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Completed PhD and postdoctoral work, having pursued a career in biomedical research after practising clinically for some years. I have recently established my independent research group and am building my independent portfolio in translational cardiac cell biology research, to expand on my previous work in this field and to further develop my research career.
Identification

Personal identification

Full name
Andrew John Smith

Citation names

  • Smith, Andrew

Author identifiers

Ciência ID
471F-96DF-9591
ORCID iD
0000-0001-7283-5611
Education
Degree Classification
2008/07
Concluded
 Neuroscience and Biomedical Systems (Doctor)
University of Glasgow, United Kingdom
"Excitotoxicity, Oxidative Stress and Neuroprotection in Cerebellar Granule Neurones" (THESIS/DISSERTATION)
2001/07
Concluded
 Bachelor of Medicine and Bachelor of Surgery (MBChB) (Doctor)
University of Aberdeen, United Kingdom
Affiliation

Science

Category
Host institution 		Employer
2015/08/03 - Current Principal Investigator (Research) University of Leeds, United Kingdom
2015 - Current Visiting Researcher (Research) Centre of Human & Aerospace Physiological Sciences, School of Biomedical Sciences, King’s College London, United Kingdom
2013/04 - 2015/06 Postdoc (Research) Centre of Human & Aerospace Physiological Sciences, School of Biomedical Sciences, King’s College London, United Kingdom
2014 - 2015 Postdoc (Research) Università Magna Graecia, Catanzaro, Italy, Italy
2009 - 2013 Postdoc (Research) Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2005 - 2007 Assistant (University Teacher) Anatomy Department, University of Glasgow, United Kingdom

Others

Category
Host institution 		Employer
2002 - 2003 2nd year House Surgeon Emergency Department, Christchurch Hospital, New Zealand
2001 - 2002 House Officer St John’s Hospital and Howden Health Centre, United Kingdom
Projects

Grant

Designation Funders
2016/10 - Current PhD project examining the mechanisms of tyrosine kinase inhibitor toxicity on human cardiac stem cells
LARS
Principal investigator
2016/02 - Current pump-priming’ grant: £23,000 for study of a novel chemical tool for cell surface ‘biopsies’ from cardiac cells
105615/Z/14/Z
Principal investigator
2016/02 - Current study into tyrosine kinase inhibitor cardiotoxicity and cardiac stem cells;
M519
Principal investigator
2014/10 - 2016/01 study into mechanisms of quiescence in endogenous cardiac stem cells
R1405168
Principal investigator
King’s Health Partners Research Fund
Concluded

Contract

Designation Funders
2019/05 - Current Identifying VEGFR roles in cardiac stem cell contribution to new vascular cell formation
PG/18/39/33618
Principal investigator
2019/03 - Current Utilising Novel 3-D bioprinting technology to translate in vitro toxicology findings into complex structures
2019-08
Principal investigator
2014/11 - 2016/11 study of effects of tyrosine kinase inhibitors on the characteristics of endogenous cardiac stem cells from the adult human heart in vitro
RG2641
Principal investigator
Concluded
Outputs

Publications

Book chapter
  1. Ellison, Georgina M.; Smith, Andrew J.; Waring, Cheryl D.; Henning, Beverley J.; Burdina, Anna O.; Polydorou, Joanna; Vicinanza, Carla; et al. "Adult Cardiac Stem Cells: Identity, Location and Potential". In Stem Cell Biology and Regenerative Medicine, 47-90. Springer New York, 2013.
    10.1007/978-1-4614-9569-7_4
Conference abstract
  1. Smith, Andrew. "Poor recovery from receptor tyrosine kinase inhibitor cardiotoxicity is linked to toxic effects on cardiac stem cells.". Paper presented in American Heart Association Scientific Sessions conference, Chicago IL, 2018.
  2. Smith, Andrew. "Cardiotoxic receptor tyrosine kinase inhibitors exert toxic effects on human cardiac stem cells and impair cardiac function". Paper presented in European Society of Cardiology Congress, Barcelona, 2017.
  3. Smith, Andrew. "Tyrosine kinase inhibitor cardiotoxicity and cardiac stem cells.". Paper presented in British Society for Cardiovascular Research conference ‘Cardiac Disease and Diabetes’, leeds, 2016.
  4. Smith, Andrew. "Cardiac Stem Cells - Advances, Uncertainties and Opportunities". Paper presented in Northern Cardiovascular Research Group congress, Leeds, 2016.
  5. Smith, Andrew. "In situ activation of endogenous cardiac stem cells alters their secretome, miRnome, potentiating their regenerative capacity on the injured heart". Paper presented in European Society of Cardiology Congress, londres, 2015.
  6. Smith, Andrew. "Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart.". Paper presented in World Biomedical Frontiers, Section of Stem Cells, 2015.
  7. Smith, Andrew. "In situ activation of endogenous cardiac stem cells alters their secretome, miRnome and potentiates their growth and self-renewal.". Paper presented in Physiological Society symposium H3 Symposia: Cellular approaches for cardiac repair: a physiological perspective, Londres, 2014.
  8. Smith, Andrew. "Activity status of resident adult cardiac stem cells determines their stem cell properties and growth kinetics". 2012.
  9. Smith, Andrew. "Endogenous cardiac stem cell (eCSC) activation, myogenesis and angiogenesis contribute to cardiac remodelling following intensity-controlled exercise training.". 2012.
  10. Smith, Andrew. "Resident adult cardiac stem cells fulfil Koch's postulates as the causative agents for myocardial regeneration and homeostasis". 2011.
  11. Smith, Andrew. "Roles of Wnt/beta-catenin and Tgf-Beta1/Smad2 signalling pathways in endogenous resident c-kit-positive cardiac stem cell proliferation and cardiomyogenic specification in vitro.". 2011.
  12. Bargo, Paulo R.; Chu, Melissa; Cole, Curtis A.; Kollias, Nikiforos. "Oxidative and nitrosative stress-induced neurotoxicity in primary rat cerebellar granule neurons.". 2009.
    10.1364/bio.2006.tui11
  13. Smith, Andrew. "Neurotoxicity of tryptophan metabolites in cultured cerebellar granule neurones. Proc. Life Sciences: C20". Paper presented in The Physiological Society Life Sciences 2007 conference, Glasgow, 2007.
  14. Smith, Andrew. "Effects of preconditioning on viability of cultured cerebellar neurones". Paper presented in at British Neuroscience Association conference, Harrogate, 2007.
Journal article
  1. Andrew J. Smith; Kathleen E. Wright; Stephen P. Muench; Sophie Schumann; Adrian Whitehouse; Karen E. Porter; John Colyer. "Styrene maleic acid recovers proteins from mammalian cells and tissues while avoiding significant cell death". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-51896-1.
    10.1038/s41598-019-51896-1
  2. Iolanda Aquila; Eleonora Cianflone; Mariangela Scalise; Fabiola Marino; Teresa Mancuso; Andrea Filardo; Andrew J. Smith; et al. "c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration". Cell Death & Disease 10 6 (2019): https://doi.org/10.1038/s41419-019-1655-5.
    10.1038/s41419-019-1655-5
  3. Aquila I; Cianflore E; Scalise M; Marino F; Mancuso T; Marotta P; Fillardo A; et al. "c-kit Haploinsufficiency Impairs Adult Cardiac Stem Cell Growth, Myogenicity and Myocardial Regeneration". Cell Death and Disease (2019):
    Under revision
  4. Smith, Andrew; Colyer J. "Styrene maleic acid recovers protein biomarkers from mammalian cells and tissues without causing cell death.". Scientific Reports (2019):
    Under revision
  5. Munsey T; Smith, Andrew. "Toxicity of receptor tyrosine kinase inhibitors in adult rat cardiac fibroblasts.". Toxicology In Vitro (2019):
    Under revision
  6. Vicinanza, Carla; Aquila, Iolanda; Scalise, Mariangela; Cristiano, Francesca; Marino, Fabiola; Cianflone, Eleonora; Mancuso, Teresa; et al. "Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification". Cell Death and Differentiation 24 12 (2017): 2101-2116. http://dx.doi.org/10.1038/cdd.2017.130.
    10.1038/cdd.2017.130
  7. Waring, Cheryl D.; Henning, Beverley J.; Smith, Andrew J.; Nadal-Ginard, Bernardo; Torella, Daniele; Ellison, Georgina M.. "Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining". Physiological Reports 3 2 (2015): e12302. http://dx.doi.org/10.14814/phy2.12302.
    10.14814/phy2.12302
  8. Smith, Andrew J; Lewis, Fiona C; Aquila, Iolanda; Waring, Cheryl D; Nocera, Aurora; Agosti, Valter; Nadal-Ginard, Bernardo; Torella, Daniele; Ellison, Georgina M. "Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart". Nature Protocols 9 7 (2014): 1662-1681. http://dx.doi.org/10.1038/nprot.2014.113.
    10.1038/nprot.2014.113
  9. Ellison, Georgina M.; Vicinanza, Carla; Smith, Andrew J.; Aquila, Iolanda; Leone, Angelo; Waring, Cheryl D.; Henning, Beverley J.; et al. "Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair". Cell 154 4 (2013): 827-842. http://dx.doi.org/10.1016/j.cell.2013.07.039.
    10.1016/j.cell.2013.07.039
  10. Waring, Cheryl D.; Vicinanza, Carla; Papalamprou, Angela; Smith, Andrew J.; Purushothaman, Saranya; Goldspink, David F.; Nadal-Ginard, Bernardo; Torella, Daniele; Ellison, Georgina M.. "The adult heart responds to increased workload with physiologic hypertrophy, cardiac stem cell activation, and new myocyte formation". European Heart Journal 35 39 (2012): 2722-2731. http://dx.doi.org/10.1093/eurheartj/ehs338.
    10.1093/eurheartj/ehs338
  11. Ellison, Georgina M.; Torella, Daniele; Dellegrottaglie, Santo; Perez-Martinez, Claudia; Perez de Prado, Armando; Vicinanza, Carla; Purushothaman, Saranya; et al. "Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart". Journal of the American College of Cardiology 58 9 (2011): 977-986. http://dx.doi.org/10.1016/j.jacc.2011.05.013.
    10.1016/j.jacc.2011.05.013
  12. Kawaguchi, Nanako; Smith, Andrew J.; Waring, Cheryl D.; Hasan, Md Kamrul; Miyamoto, Shinka; Matsuoka, Rumiko; Ellison, Georgina M.. "c-kitpos GATA-4 High Rat Cardiac Stem Cells Foster Adult Cardiomyocyte Survival through IGF-1 Paracrine Signalling". PLoS ONE 5 12 (2010): e14297. http://dx.doi.org/10.1371/journal.pone.0014297.
    10.1371/journal.pone.0014297
  13. Darlington, L. Gail; Forrest, Caroline M.; Mackay, Gillian M.; Smith, Robert A.; Smith, Andrew J.; Stoy, Nicholas; Stone, Trevor W.. "On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio". International Journal of Tryptophan Research 3 (2010): IJTR.S4282. http://dx.doi.org/10.4137/ijtr.s4282.
    10.4137/ijtr.s4282
  14. Smith, Andrew J.; Tauskela, Joseph S.; Stone, Trevor W.; Smith, Robert A.. "Preconditioning with 4-aminopyridine protects cerebellar granule neurons against excitotoxicity". Brain Research 1294 (2009): 165-175. http://dx.doi.org/10.1016/j.brainres.2009.07.061.
    10.1016/j.brainres.2009.07.061
  15. Smith, Andrew J.; Smith, Robert A.; Stone, Trevor W.. "5-Hydroxyanthranilic Acid, a Tryptophan Metabolite, Generates Oxidative Stress and Neuronal Death via p38 Activation in Cultured Cerebellar Granule Neurones". Neurotoxicity Research 15 4 (2009): 303-310. http://dx.doi.org/10.1007/s12640-009-9034-0.
    10.1007/s12640-009-9034-0
  16. Smith, Andrew J.; Stone, Trevor W.; Smith, Robert A.. "Preconditioning with NMDA protects against toxicity of 3-nitropropionic acid or glutamate in cultured cerebellar granule neurons". Neuroscience Letters 440 3 (2008): 294-298. http://dx.doi.org/10.1016/j.neulet.2008.05.066.
    10.1016/j.neulet.2008.05.066
  17. Smith, A.J.; Stone, T.W.; Smith, R.A.. "Neurotoxicity of tryptophan metabolites". Biochemical Society Transactions 35 5 (2007): 1287-1289. http://dx.doi.org/10.1042/bst0351287.
    10.1042/bst0351287
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017/06 Use of Styrene Maleic Acid as a Novel Cardiovascular Cell Biopsy Tool. Nanoparticle technologies meeting
(Leeds, United Kingdom)
2016/04 Cardiac Stem Cells - Advances, Uncertainties and Opportunities. Northern Cardiovascular Research Group congress
(Leeds, United Kingdom)
2015/11 Endogenous cardiac stem cells’ activation in response to injury potentiates their regenerative ability. American Heart Association Scientific Sessions conference
(Orlando, United States)
2013/11 Effects of in situ activation upon the properties and characteristics of endogenous cardiac stem cells. Regenerative Medicine: from biology to therapy’
(Cambridge, United Kingdom)
2011/07 Activity status of resident adult cardiac stem cells determines their stem cell properties and growth kinetics. European Society of Sports Science conference
(Liverpool, United Kingdom)
2010/11 Resident adult rat cardiac stem cells fulfil Koch’s postulates as the causative agents for myocardial regeneration and homeostasis American Heart Association Scientific Sessions conference
(Chicago IL, United States)
2007/07 Neurotoxicity of tryptophan metabolites in cultured cerebellar granule neurones The Physiological Society Life Sciences 2007 conference
(Glasgow, United Kingdom)
2006/08 Effects of preconditioning on viability of cultured cerebellar neurones Institute of Biological Sciences
National Research Council of Canada (Ottawa, Canada)

Journal scientific committee

Journal title (ISSN) Publisher
2017/07 - Current British Heart Foundation
2016/02 - Current Scientific Reports
2016/01 - Current Medical Research Council
2016/01 - Current Europace
2016 - Current Rosetrees Trust
2014/04 - Current Journal of Biomedical Science
2014/03 - Current Scandinavian Journal of Medicine and Science in Sports