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Luísa V. Lopes (b. 1975, Lisbon, Portugal) is a neuroscientist at the Instituto de Medicina Molecular-João Lobo Antunes in Lisbon, Portugal; studying the mechanisms inducing the "early-aging" of cognitive function, focusing on hippocampal circuitry and related behavior. She is a Biochemistry graduate from University of Lisbon (1998). During her PhD, carried out between the University of Lisbon, University of Cambridge, UK and the Karolinska Institute in Stockholm, she has detailed the role of a specific receptor for adenosine in the aged brain, the A2A, which affects glutamate release and cognition. In 2003, Luisa moved to Lausanne, Switzerland for a postdoc at the Nestlé Research Center, implementing new models to study the impact of chronic stress on memory and brain-gut interactions. In 2008, she joined the Instituto de Medicina Molecular-João Lobo Antunes in Lisbon as a staff scientist, and in 2013 became a Group Leader (https://imm.medicina.ulisboa.pt/investigation/laboratories/luisa-lopes-lab/#intro). Her team has pinpointed circadian disorders as a trigger for accelerated cognitive loss (Mol. Psychiatry, 2013; Scientific Reports, 2016)), established one of the underlying mechanisms for early synaptic degeneration in the hippocampus (Nature Neuroscience, 2017); and most recently, evidence of a neuro-immune link in short-term memory (Sci Immunol, 2019). She is currently focused on implementing novel ageing-equivalent models to study human synaptic function (Mol. Psychiatry 2018; Cell Rep 2019). Luisa has received public and private funding (FCT, Fritz Thyssen Foundation, EMBO, Bial, Santa Casa and EUH2020); she is a Mentor of the New York Academy of Sciences STEM program and founder of the Society for Neuroscience Lisbon Chapter. In 2019 she was one of the awardees of the Interstellar Initiative for Healthy Aging, promoted by the New York Academy of Sciences and Japan Agency for Medical Research and Development.
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Identification

Personal identification

Full name
Luisa Vaqueiro Lopes
Date of birth
1975/07/04
Gender
Female

Citation names

  • Lopes, Luisa
  • Luísa V. Lopes

Author identifiers

Ciência ID
4817-7194-C024
ORCID iD
0000-0001-8367-3005

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Projects

Grant

Designation Funders
2023 - 2025 La Caixa Impulse Innovation Award 2023 - Luminopsins in Parkinson’s disease stimulation
CI23-10184
Principal investigator
Fundação 'la Caixa', Portugal
Ongoing
2021/06 - 2024/06 Assessing aging of human neurons by direct induced neuronal (iN) conversion
PTDC/MED-NEU/3890/2020
Principal investigator
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2021/03 - 2024/03 Regulação da homeostasia da células T &#947;&#948;17 nas meninges:<br>Mecanismos moleculares e consequências patofisiologicas.
Provided by PTCRIS: PTDC/MED-IMU/1988/2020
 Fundação para a Ciência e a Tecnologia
2021/03 - 2024/02 Estudo das propriedades sináticas do envelhecimento em neurónios humanos derivados por conversão direta
Provided by PTCRIS: PTDC/MED-NEU/3890/2020
 Fundação para a Ciência e a Tecnologia
2021/03 - 2022/03 Cholinergic signature in fast versus slow cognitive decline upon aging
N/A
Principal investigator
Ongoing
2018/10 - 2022/03 Coordenacao hipocampo-cortical e mecanismos cognitivos: a formacao e recuperacao das memorias episodicas durante o comportamento decisional
Provided by PTCRIS: PTDC/MED-NEU/29325/2017
 Fundação para a Ciência e a Tecnologia
2018/06 - 2021/12 Impacto das células T gd17 residentes nas meninges em funções cognitivas num contexto fisiológico e neuropatológico
Provided by PTCRIS: PTDC/MED-IMU/28241/2017
 Fundação para a Ciência e a Tecnologia
2016/06 - 2020/02 Defesas anti-glicação como alvo terapêutico para a doença de Parkinson
Provided by PTCRIS: PTDC/NEU-OSD/5644/2014
 Fundação para a Ciência e a Tecnologia
2013/06 - 2018/06 Exploring the basis of hippocampal dysfunction in ageing and Alzheimer's disease
Provided by PTCRIS: IF/00105/2012/CP0163/CT0002
 Fundação para a Ciência e a Tecnologia
2011/07 - 2014/12 Determinantes moleculares da activação da microglia e da disfunção neuronal em modelos in vivo da doença de Parkinson
Provided by PTCRIS: PTDC/SAU-ORG/114083/2009
 Fundação para a Ciência e a Tecnologia
2010/02 - 2013/07 Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF
Provided by PTCRIS: PTDC/SAU-NEU/101928/2008
 Fundação para a Ciência e a Tecnologia
2008/02 - 2013/01 Chronic stress and function of hippocampal adenosine A2A receptors
Provided by PTCRIS: CONT_DOUT/32/IMM/69/5667/ 6/2006
 Fundação para a Ciência e a Tecnologia
2010/01 - 2012/12 Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória
Provided by PTCRIS: PTDC/SAU-NEU/099853/2008
 Fundação para a Ciência e a Tecnologia
2008/05 - 2011/05 Receptores de membrana e mediadores envolvidos nas alterações plásticas induzidas por agressões neuronais: implicações para a neuroprotecção
Provided by PTCRIS: PTDC/SAU-FCF/68607/2006
 Fundação para a Ciência e a Tecnologia
2006/02 - 2008/01 CHRONIC STRESS AND FUNCTION OF HIPPOCAMPAL ADENOSINE A2A RECEPTORS
Provided by PTCRIS: SFRH/BPD/21583/2005
 Fundação para a Ciência e a Tecnologia
2000/02 - 2003/01 ADENOSINE RECEPTORES CROSSTALK IN THE RAT HIPPOCAMPUS: FUNCTIONAL AND BIOCHEMICAL MECHANISMS
Provided by PTCRIS: PRAXIS XXI/BD/21267/99
 Fundação para a Ciência e a Tecnologia
1999/02 - 2000/01 INTERACTION BETWEEN A1 AND A2A ADENOSINE RECEPTORS IN THE HIPROCAMPUS
Provided by PTCRIS: PRAXIS XXI/BIC/17286/98
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Journal article
  1. Cátia Reis; Luísa K. Pilz; Achim Kramer; Luísa V. Lopes; Teresa Paiva; Till Roenneberg. "The impact of daylight-saving time (DST) on patients with delayed sleep-wake phase disorder (DSWPD)". Journal of Pineal Research (2023): https://doi.org/10.1111/jpi.12867.
    10.1111/jpi.12867
  2. Joana Rajão-Saraiva; Jade Dunot; Aurore Ribera; Mariana Temido-Ferreira; Joana E. Coelho; Svenja König; Sébastien Moreno; et al. "Age-dependent NMDA receptor function is regulated by the amyloid precursor protein". Aging Cell 22 (2023):
    Open access • Published • 10.1111/acel.13778
  3. "S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5". Neurobiology of disease (2022): https://doi.org/10.1016/j.nbd.2021.105603.
    10.1016/j.nbd.2021.105603
  4. "Transection of the Superior Sagittal Sinus Enables Bilateral Access to the Rodent Midline Brain Structures". eNeuro (2021): https://europepmc.org/articles/PMC8281263.
    10.1523/eneuro.0146-21.2021
  5. "IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease". Cell reports (2021): https://doi.org/10.1016/j.celrep.2021.109574.
    10.1016/j.celrep.2021.109574
  6. "Stabilizing synapses". Science (New York, N.Y.) (2021): https://doi.org/10.1126/science.abm3902.
    10.1126/science.abm3902
  7. Adam Armada-Moreira; Joana E. Coelho; Luísa V. Lopes; Ana M. Sebastião; Brigitte Städler; Sandra H. Vaz. "Multicompartment Microreactors Prevent Excitotoxic Dysfunctions In Rat Primary Cortical Neurons". Advanced Biosystems (2020): 2000139-2000139. https://doi.org/10.1002/adbi.202000139.
    10.1002/adbi.202000139
  8. "Adenosine Receptors as Neuroinflammation Modulators: Role of A<sub>1</sub> Agonists and A<sub>2A</sub> Antagonists". Cells (2020): https://europepmc.org/articles/PMC7409197.
    10.3390/cells9071739
  9. "Validation of the Portuguese Variant of the Munich Chronotype Questionnaire (MCTQ<sup>PT</sup>)". Frontiers in physiology (2020): https://europepmc.org/articles/PMC7372122.
    10.3389/fphys.2020.00795
  10. "Modeling human age-associated increase in Gadd45¿ expression leads to spatial recognition memory impairments in young adult mice". Neurobiology of aging (2020): https://doi.org/10.1016/j.neurobiolaging.2020.06.021.
    10.1016/j.neurobiolaging.2020.06.021
Preprint
  1. Joana Gomes-Ribeiro; João Martins; José Sereno; Samuel Deslauriers-Gauthier; Teresa Summavielle; Joana E. Coelho; Miguel Remondes; Miguel Castelo Branco; Luísa V. Lopes. "Mapping functional traces of opioid memories in the rat brain". 2023. https://doi.org/10.1101/2023.08.07.552221.
    10.1101/2023.08.07.552221
  2. Joana Rajao-Saraiva; Mariana Temido-Ferreira; Joana E Coelho; Aurore Ribera; Sebastien Moreno; Michael Willem; Helene Marie; Luisa V. Lopes; Paula A Pousinha. "Age-dependent NMDA receptor function is regulated by the Amyloid Precursor Protein". 2022. https://doi.org/10.1101/2022.07.20.500736.
    10.1101/2022.07.20.500736

Other

Other output
  1. Glycation modulates glutamatergic signalling and exacerbates Parkinson’s disease-like phenotypes. 2021. Ana Chegão; Mariana Guarda; Bruno M. Alexandre; Liana Shvachiy; Mariana Temido-Ferreira; Inês Marques-Morgado; Bárbara Fernandes Gomes; et al. https://doi.org/10.1101/2021.08.24.457507.
    10.1101/2021.08.24.457507
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - Current PhD thesis (2018- ) Joana Ribeiro - "Encoding of temporal and spatial cues in drug-seeking behavior"¿ Programa doutoral LisbonBiomed, IMM (co-supervisor M. Remondes)
Supervisor
 PhD (PhD)
Instituto de Medicina Molecular, Portugal
2017 - Current PhD thesis (2017-2022) Inês Morgado “Structural and functional connectivity between SCN and hippocampus upon aging” Programa doutoral NeuroLisboa, FML (co-supervisor M. Remondes)
Supervisor
2018 - 2023 PhD thesis (2018 - ) Joana Saraiva "Mechanisms underlying the physiological role of APP in glutamatergic synapses¿ Programa doutoral LisbonBiomed, IMM "
Supervisor of Joana Rajão-Saraiva
 PhD (PhD)
Instituto de Medicina Molecular, Portugal
2017 - 2020 PhD thesis (2017-2020) Cátia Reis “Sleep patterns in Portugal: European and International comparisons “ Programa doutoral EnviHealth, FMUL
Co-supervisor
2016 - 2020 PhD thesis (2017-2020) Helena Brigas "Searching for innate and adaptive immune cell fingerprints in Alzheimer¿s disease progression" Programa doutoral LisbonBiomed, IMM (co-orientador)
Co-supervisor
 PhD

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Since 2022 – Board of the Association of the Academical Medical Center Lisbon Since 2019 - Coordination Board of the Biomedical Research Master Course, (IMM; FML) Since 2019 – Organizer of the NeuroSeS meetings (clinical and fundamental neuroscience seminars in our campus) Since 2021 – Coordinator (regente) of the undergraduate module ‘Translational Neuroscience’ Faculty Medicine Lisbon Since 2012 – Member of the Scientific Board, Faculty Medicine, University of Lisbon Since 2019 – Founder and Head of the Society for Neuroscience Lisbon Cha
Distinctions

Award

2022 CEEC FCT position award (Coordinator)
Fundação para a Ciência e a Tecnologia, Portugal