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Jéssica Mendes Costa.
Identification

Personal identification

Full name
Jéssica Mendes Costa

Citation names

  • Costa, Jéssica

Author identifiers

Ciência ID
481D-5020-DA48
ORCID iD
0000-0002-6652-2907

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/10/07 - 2024
Ongoing
 PhD programme in Experimental Biology and Biomedicine (Doutoramento)
Major in Especialização em Neurobiology of Disease Universidade de Coimbra, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/01/07 - 2019/01/18
Concluded
 II Modular Training in Laboratory Animal Science (Outros)
CNC.IBILI, Portugal
 17
2018
Concluded
 Master's degree in Biomedical Research (Mestrado)
Major in Neurobiology
Universidade de Coimbra Faculdade de Medicina, Portugal
"The impact of Early-Life stress Throughout Life: Maternal Separation-Induced Changes in Behavior and Microglia Morphology" (THESIS/DISSERTATION)
 19
2016/07
Concluded
 Bachelor degree in Biomedical Pharmacy (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 16
Affiliation

Others

Category
Host institution 		Employer
2019/12/01 - Current PhD Student CNC.IBILI, Portugal
2018/11/02 - 2019/11/01 Research Fellowship in the scope of the project Brain Health 2020 - Precocious Detection, Neuro-modulation and Advanced Therapies (ref. CENTRO-01-0145-FEDER-000008) CNC.IBILI, Portugal
Outputs

Publications

Conference poster
  1. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica; Laranjo, Mariana B.; Reis, Tiago; Cardoso, A.M.; LEBRE, CAROLINA; et al. "Allergies and IL-4 shape postnatal cerebellar development via microglia-mediated neuronal pruning to induce ADHD-like behaviors in mice". Paper presented in FENS Forum 2022, 2022.
  2. Ferreira, P.A.; Guedes, J. R.; Reis, Tiago; Costa, Jéssica; Cardoso. A. L.; Peça, João. "Postnatal L-4 administration induces long-term dysfunction in cerebellar-VTA connectivity". Paper presented in FENS Forum 2022, 2022.
  3. Cardoso, A.L.; Costa, Jéssica; Martins, Solange; Carolina Kunicki; Ferreira, P.A.; Guedes, J. R.; Peça, João. "Exposure to early-life stress promotes sex-dependent changes in microglia morphology and phagocytic activity in the prefrontal cortex". Paper presented in FENS Forum 2022, 2022.
  4. Costa, Jéssica; Martins, Solange; Carolina Kunicki; Ferreira, P.A.; Guedes, J. R.; Peça, João; Cardoso, A.L.. "Early-life adversity induces sex-specific dysfunction of the mPFC and leads to impulsive, hyperactive, and risk-taking behaviors in juvenile male mice". Paper presented in FENS Forum 2022, 2022.
  5. Franco, Lara Oliveira; Carvalho, Mário J. ; Costa, Jéssica; Ferreira, P.A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al. "Early life stress and social hierarchies: The role of cortico-striatal circuits". Paper presented in 13th Symposium of Bial Foundation, 2022.
  6. Costa, Jéssica; Martins, Solange; Ferreira, P.A.; LEBRE, CAROLINA; Guedes, J. R.; Franco, Lara Oliveira; Peça, João; Cardoso, Ana L.. "The influence of maternal bonding in neuroimmune synaptic function". Paper presented in 13th Symposium of Bial Foundation13th Symposium of Bial Foundation, 2022.
  7. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica; Laranjo, Mariana; Reis, Tiago; Cardoso, A.M.; Gomes, M; et al. "Abnormal microglia-mediated pruning in the cerebellum induces circuitry and behavioral dysfunction in mice". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  8. Cardoso, Ana; Costa, Jéssica; Martins, Solange; Ferreira, P.A.; Guedes, J. R.; Carvalho, MJ; Peça, João. "Early-life stress causes sex-dependent changes in microglia function, circuit wiring and behavior in the mPFC". Paper presented in 12th FENS Forum of Neuroscience, Glasgow, Scotland, 2020.
  9. Costa, Jéssica; Guedes, J. R.; Ferreira, P.A.; Franco, Lara Oliveira; Peça, João; Cardoso, Ana. "Early-life stress causes behavior changes and microglia dysfunction in the pre-frontal cortex of male mice". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  10. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica; Cardoso, Ana; Peça, João. "IL-4 skews the microglial developmental program during cerebellar maturation". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  11. Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica; Pereira, Marta; Cardoso, Ana; Peça, João. "Microglia-dependent remodeling of cerebellar circuits". Paper presented in Gordon Research Conference - Neuroimmune Communication in Health and Disease, Exploring Neuroimmunology: From Single Cells to Organisms, 2019.
Journal article
  1. Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al. "IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development". Neuron 111 21 (2023): 3435-3449.e8. http://dx.doi.org/10.1016/j.neuron.2023.09.031.
    10.1016/j.neuron.2023.09.031
  2. Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João. "Microglia-dependent remodeling of neuronal circuits". Journal of Neurochemistry 163 2 (2022): 74-93. http://dx.doi.org/10.1111/jnc.15689.
    10.1111/jnc.15689
  3. Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512.
    10.1016/j.mad.2021.111512
  4. Franco, Lara Oliveira; Carvalho, Mário Jorge da Silva; Costa, Jéssica; Ferreira, P.A.; Guedes, J. R.; Sousa, Renato; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology 45 (2020): 1438-1447.
    Open access • Published
Preprint
  1. Carvalho, Ana Luisa; Rodrigues, Beatriz; Leitão, Ricardo; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". 2023. http://dx.doi.org/10.21203/rs.3.rs-3405749/v1.
    10.21203/rs.3.rs-3405749/v1
Thesis / Dissertation
  1. Costa, Jéssica. "The impact of early-life stress troughout life: maternal separation-induced changes in behavior and microglia morphology". Master, Universidade de Coimbra Faculdade de Medicina, 2018. http://hdl.handle.net/10316/82809.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 IL-4 skews the microglial developmental program during cerebellar maturation XVI Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Lisboa, Portugal)
2018/10/13 Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress 52th International Congress on Microscopy and Microanalysis
Portuguese Miroscopy Society (Coimbra, Portugal)

Mentoring / Tutoring

Topic Student name
2019/05/01 - 2019/06/01 Deciphering the neuronal functions of SNAP-29 and its implications in neuropsychiatric disorders: Behavioral charaterization of a new mouse model Solange Martins
2019/04/01 - 2019/05/01 Deciphering the neuronal functions of SNAP-29: Relevance in synaptic physiology and implications in neuropsychiatric disorders Catarina Pacheco
Distinctions

Other distinction

2019 Individual 4-year PhD Fellowship (Ref: SFRH/BD/144875/2019)
Fundação para a Ciência e a Tecnologia, Portugal