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Identification

Personal identification

Full name
Márcia Sofia Silva Martins

Citation names

  • Márcia S. Martins
  • Márcia Martins

Author identifiers

Ciência ID
4918-C433-853B
ORCID iD
0000-0003-3958-6849

Email addresses

  • msofiasm.1312@gmail.com (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/12/01 - 2025/11/30
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Major in Química Farmacêutica e Medicinal
Universidade do Porto Faculdade de Farmácia, Portugal
2022/12/13 - 2022/12/16
Concluded
 Flow Cytometry: from basic knowledge to practical applications (Outros)
Universidade do Porto Faculdade de Farmácia, Portugal
 20
2019/09 - 2021/10/18
Concluded
 Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Synthesis and neuroprotection studies of new xanthenes and fluorenes" (THESIS/DISSERTATION)
 18
2016/09 - 2019/07/19
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Putting membrane lipids on the radar of drug development: the case of nonsteroidal anti-inflammatory drugs associated with protective mediators" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2021/12/01 - Current Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2020/08/01 - 2021/10/30 Research Trainee (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2018/11 - 2019/07 Research Trainee (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)

Others

Category
Host institution 		Employer
2018/02/01 - 2018/07/31 Intership - alfa-caseins phylogeny, adaptative selection and correlation with phenotypic traits analysis Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
(...)
Projects

Grant

Designation Funders
2021/12/01 - Current Discovery of new marine inspired substance P antagonists as therapeutic agents for common and rare dermatological diseases
2021.05964.BD
PhD Student Fellow
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09/01 - 2021/09/30 Toxicological evaluation of compounds with potential antimicrobial activity
Verão com Ciência
Scientific Initiation Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/09/01 - 2021/06/30 BYT+ Towards the discovery of tricyclic compounds with potential neuroprotective properties
Não se aplica
Master Student Fellow
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental

Fundação Amadeu Dias
Concluded
Outputs

Publications

Conference abstract
  1. Monteiro, A. R.; Maia, M.; Márcia S. Martins; E. Sousa; Remião, F.; R. Silva. Corresponding author: R. Silva. "Insights into the neuroprotective effects of novel synthetic compounds as potential small molecules for the treatment of Alzheimer's disease". Paper presented in 57TH Congress of the European Societies of Toxicology, Ljubljana, 2023.
    Published • https://doi.org/10.1016/S0378-4274(23)00828-7
  2. Márcia S. Martins; Miguel Maia; Eva Gil-Martins; Luís Gales; Fernando Remião; Madalena M. M. Pinto; Renata Silva; Emília Sousa. Corresponding author: Emília Sousa. "Synthesis and Neuroprotection Studies of New Tricyclic Compounds". Paper presented in 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting, Caparica, Lisboa, 2022.
    Published • 10.3390/chemproc2022011001
  3. Martins, Márcia; Maia, M.; Gil-Martins, E.; Gales, L.; Remião, F.; Pinto, M. M. M.; Silva, R.; Sousa, E.. "Towards the development of potential dual GSK-3ß/BACE-1 inhibitors: a strategy to fight Alzheimer's disease". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX 2021), 2021.
    Published • https://doi.org/10.1016/S0378-4274(21)00507-5
Conference poster
  1. Márcia S. Martins; Solida Long; Madalena M. M. Pinto; Almeida, Isabel F.; Maria T. Cruz; Emília Sousa. Corresponding author: Emília Sousa. "Battling pruritic inflammatory skin diseases with inspiration in the oceans". Paper presented in Blue Think Conference 2023, 2023.
  2. Márcia S. Martins; Maria T. Cruz; Almeida, Isabel F.; Emília Sousa. Corresponding author: Emília Sousa. "Targeting Skin Pruritic Inflammatory Diseases with New Marine-Inspired Compounds". Paper presented in European School of Medicinal Chemistry 42nd Advanced Course of Medicinal Chemistry and Seminar for PhD students, 2023.
  3. Pedro Gomes; Miguel Maia; Márcia S. Martins; Emília Sousa; Lucília Saraiva. Corresponding author: Lucília Saraiva. "Identification of xanthene derivatives inhibitors of mutant G2019S of Leucine Rich Repeat Kinase 2 (LRRK2) in yeast". Paper presented in IJUP '23 – 16th Meeting of Young Researchers of the University of Porto, 2023.
  4. Ana Rita Monteiro; Miguel Maia; Márcia S. Martins; Emília Sousa; Fernando Remião; Renata Silva. Corresponding author: Renata Silva. "New P-glycoprotein activators as potential small molecules for the treatment of Alzheimer's disease". Paper presented in IJUP '23 - 16th Meeting of Young Researchers of the University of Porto, 2023.
  5. Márcia S. Martins; Solida Long; Ana Jesus; Honorina Cidade; Madalena M. M. Pinto; Isabel F. Almeida; Maria T. Cruz; Emília Sousa. Corresponding author: Emília Sousa. "Fiscalins: a new source of substance P antagonists?". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022.
  6. Márcia S. Martins; Solida Long; Madalena M. M. Pinto; Isabel F. Almeida; Maria T. Cruz; Emilia Sousa. Corresponding author: Emilia Sousa. "New Marine-Inspired Compounds As Dual Anti-Pruritic/Anti-Inflammatory Agents". Paper presented in 13th International Conference on Skin Ageing and Challenges, 2022.
  7. Márcia S. Martins; Marta S. Ferreira; Isabel F. Ferreira; Emília Sousa. Corresponding author: Emília Sousa. "Cosmetics for sensitive skin: presence of allergens". Paper presented in Blue Think Conference 2022, 2022.
  8. Márcia Martins; Miguel Maia; Eva Gil-Martins; Luís Gales; Fernando Remião; Madalena M. M. Pinto; Renata Silva; Emília Sousa. Corresponding author: Emília Sousa. "Towards the development of potential dual GSK-3ß/BACE-1 inhibitors: a strategy to fight Alzheimer's disease". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX 2021), 2021.
  9. Martins, Márcia; Maia, M.; Gil-Martins, E.; Gales, L.; Remião, F.; Pinto, M.; Silva, R.; Sousa, E.. "Tricyclic compounds as potential dual BACE-1/GSK-3ß inhibitors: synthesis and neuroprotection studies". Paper presented in Blue Think Conference 2021, 2021.
  10. Márcia Martins; Miguel Maia; Eva Gil-Martins; Luís Gales; Fernando Remião; Madalena M. M. Pinto; Renata Silva; Emília Sousa. "Synthesis, structure elucidation, and neuroprotection studies of a library of compounds with potential neuroprotective properties". Paper presented in Concurso de Posters Científicos das VI Jornadas da Bioquímica, 2021.
  11. M. Martins; M. Maia; R. Silva; M. M. M. Pinto; E. Sousa. "Synthesis of compounds with potential neuroprotective properties". Paper presented in Concurso de Pósteres das Olimpíadas Universitárias da Bioquímica - Edição Especial COVID-19 (Ref. R13), 2021.
  12. C. Pereira Leite; B. Gomes; M. Martins; C. Nunes; S. Reis. "Lipid interfaces in drug development: focusing on nonsteroidal antiinflammatory drugs". Paper presented in 2019 FEBS Advanced Lecture Course - Biological Surfaces and Interfaces: The Mechanistic View, 2019.
  13. Martins, Márcia; Nunes, Cláudia; Reis, Salette; Pereira-Leite, Catarina. "New anti-inflammatory drugs: less, equal or more topical actions on membrane lipids?". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
Journal article
  1. Márcia S. Martins; Isabel F. Almeida; Maria T. Cruz; Emília Sousa. Corresponding author: Emília Sousa. "Chronic pruritus: From pathophysiology to drug design". Biochemical Pharmacology 212 (2023): 115568-115568. http://dx.doi.org/10.1016/j.bcp.2023.115568.
    Open access • Published • 10.1016/j.bcp.2023.115568
  2. Ana Torres; Liliana Rego; Márcia S. Martins; Marta S. Ferreira; Maria T. Cruz; Emília Sousa; Isabel F. Almeida. "How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies". Pharmaceuticals (2023): https://doi.org/10.3390/ph16040573.
    10.3390/ph16040573
  3. Martins, Márcia S.; Ferreira, Marta S.; Almeida, Isabel F.; Sousa, Emília. Corresponding author: Almeida, Isabel F.. "Occurrence of Allergens in Cosmetics for Sensitive Skin". Cosmetics 9 2 (2022): 32. http://dx.doi.org/10.3390/cosmetics9020032.
    Published • 10.3390/cosmetics9020032
  4. Márcia Martins; Renata Silva; Madalena M. M. Pinto; Emilia Sousa. "Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease". Pharmaceuticals 13 9 (2020): 242. https://www.mdpi.com/1424-8247/13/9/242.
    Published • 10.3390/ph13090242

Intellectual property

Provisional application for patent
  1. 2023. "Tricyclic compounds and uses thereof".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/22 Marine-Inspired Dual-Function Compounds: Novel Substance P Antagonists for Pruritus-Associated Inflammatory Skin Conditions XXVII Encontro Luso Galego de Química
(Porto, Portugal)
2023/02/01 Looking into the sea for new anti-pruritic and anti-inflammatory agents 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2022/11/18 Tricyclic compounds derivatives as new potential neuroprotective agents XXVI Encontro Galego-Portugués de Química
Sociedade Portuguesa de Química/Colégio Oficial de Químicos da Galiza/Associação de Químicos da Galiza (Galiza, Spain)
2022/07/13 Why do we itch? À conversa sobre: Inovação, tendências e oportunidades em Química Cosmética
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2022/04/20 Synthesis and neuroprotection studies of new tricyclic compounds 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting
Sociedade Portuguesa de Química (Caparica, Lisboa, Portugal)
2021/05/19 Towards the discovery of small molecules with potential neuroprotective properties 7th Portuguese Young Chemists Meeting
Sociedade Portuguesa de Química (Online meeting)
2021/05/05 Synthesis and in vitro evaluation of compounds with potential against Alzheimer's Disease IJUP'21 - Encontro de Investigação Jovem da Universidade do Porto, 14ª Edição
Universidade do Porto (Porto, Portugal)
2020/11/24 Synthesis of potential dual BACE-1/GSK-3ß inhibitors to fight Alzheimer's disease SIFFUP, Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto, 2.ª edição
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/02/22 - 2018/02/23 Dias Abertos - Uma iniciativa que permite dar a conhecer os cursos da faculdade e respetivas saídas profissionais aos alunos que frequentam o 10.º, 11.º e 12.º ano de escolaridade (2018/02/22 - 2018/02/23)
Other (Co-organisor)
 Universidade do Porto Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/07/13 - 2022/07/13 À conversa sobre: Inovação, tendências e oportunidades em Química Cosmética À conversa sobre: Inovação, tendências e oportunidades em Química Cosmética
Universidade do Porto Faculdade de Farmácia, Portugal

Other jury / evaluation

Activity description Institution / Organization
2021/12/06 - 2021/12/09 Invited Jury to the evaluation of poster communications at "Jornadas Pedagógico-Científicas Madalena Pinto '21" Universidade do Porto Faculdade de Farmácia, Portugal
Distinctions

Award

2021 Best BYT+ 2020/2021 Internship "Towards the discovery of tricyclic compounds with potential neuroprotective properties"
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Fundação Amadeu Dias, Portugal

Other distinction

2023 Fellowship to attend the 42nd edition of the ESMEC School conceded by the ESMEC2023 Organizing Comittee
2021 Bursary to attend EUROTOX2021 conceded by the EUROTOX 2021 Congress Organizers
EUROTOX, Belgium