Bruno Costa da Silva (4A16-3B86-CF3C)

Curriculum Vitae

Bruno Costa da Silva

I have training in cells biology, including cellular and molecular neurobiology, developmental biology and oncology. During my postdoctoral training I spearheaded a project to investigate how tumor-derived extracellular vesicles (EVs) induce a series of cell-to-cell signalling and tissue remodelling events that support liver metastasis, showing for the first time the detailed mechanism of hepatic pre-metastatic niches formation (Costa-Silva et al, Nature Cell Biology, 2015). In addition, I participated on the first description of genomic double-stranded DNA packaging in tumor-derived exosomes and co-first authored a project, which showed that particular exosomal integrins define the tissue affinity of tumor-derived exosomes and as consequence tumor organotropism (Hoshino, Costa-Silva et al., Nature, 2015). Since 2016, when I established the first group to research cancer biology at the Champalimaud Foundation, I maintain productive collaborations with our Clinical Center and other European institutions, as a member since 2019 of the recently founded European Liquid Biopsies Society. In the last few years our group has focused on identifying new or poorly understood biological functions of EVs, issues we believe may impact all diseases (oncologic or not) mediated by EVs. More specifically, we are interested in occurrences after exocytosis of EVs; i.e. protein interactions and their biological implications, e.g. the activity of EVs and their bound proteins. For that, we have developed of functional EVs protein interaction assays (unpublished) applicable for cancer patient’s diagnosis, based on the capability of EVs to interact with specific proteins of interest. To further explore that, our group has successfully developed new technologies that enable mapping and monitoring of interactions between EVs and proteins; e.g. a vesicles flow cytometry method that enables fast analysis of EVs’ surface composition (Maia et al. 2020). Our group has successfully used this method for expedited analysis of proteins at the surface of EVs from cancer patient-derived plasma samples (unpublished results).

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Identification

Personal identification

Full name: Bruno Costa da Silva

Citation names

Costa-Silva, Bruno

Author identifiers

Ciência ID: 4A16-3B86-CF3C
ORCID iD: 0000-0002-5932-6211
Google Scholar ID: 5uz9pbMAAAAJ&hl

Email addresses

bruno.costadasilva@research.fchampalimaud.org (Professional)

Addresses

Champalimaud Centre for the Unknown. Av. Brasília, Doca de Pedrouços, 1400-038, Lisboa, Lisboa, Portugal (Professional)

Websites

https://fchampalimaud.org/pt-pt/research/groups/costa-silva (Scholar)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Affiliation

Science

	Category Host institution	Employer
2016/02 - Current	Principal Investigator (Research)	Programa Champalimaud de Neurociências, Portugal

Others

	Category Host institution	Employer
2015/07/01 - 2015/12/01	Instructor of Cellular and Developmental Biology	Weill Cornell Medicine, United States

2013/03/01 - 2015/12/01	Visiting Scientist at Richard Kolesnick's Laboratory	Memorial Sloan Kettering Cancer Center, United States

2011/08/01 - 2015/07/01	Postdoctoral training - David Lyden's Laboratory	Weill Cornell Medicine, United States

Projects

Contract

	Designation	Funders
2019 - 2023	Defining the Role of Exosome-Secreted Micropeptides in Pancreatic Cancer LCF/PR/HR19/52160014 Researcher Fundação Champalimaud, Portugal	Ongoing
2018 - 2023	Tumor- and stroma-derived exosomes populations associated with liver metastasis 3921 Principal investigator Fundação Champalimaud, Portugal	European Molecular Biology Laboratory Ongoing
2018 - 2021	Developmental and transgenerational effects of oxytocin-like peptides on social behavior: an eco-evo-devo approach using zebrafish as a model PTDC/BIA-COM/30627/2017 Researcher Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Diffuse Large B-cell lymphoma blood-based proteome signatures PTDC/BTM-TEC/30087/2017 Researcher Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Bosutinib effects in pre-metastatic niche formation and lung metastasis in breast cancer 2017NovPCC1058 Principal investigator Fundação Champalimaud, Portugal	Breast Cancer Now Ongoing
2018 - 2021	European Liquid Biopsies Academy - Towards widespread clinical application of blood based diagnostic tools 765492	European Commission
2018 - 2021	Metabolic chronic diseases stratification: a case for gut-liver axis derived exosomes PTDC/MEC-MET/29314/2017	Fundação para a Ciência e a Tecnologia
2018 - 2021	The role of metastatic microenvironment in Multiple Myeloma extramedullary disease. (EMphAsIS: Extramedular MyelomA mIcroenvironment Study) PTDC/MEC-HEM/30315/2017	Fundação para a Ciência e a Tecnologia
2017 - 2019	Phenotypic characterization of Liver-derived exosomes populations associated with liver metastasis in pancreatic cancers 751547 Researcher	European Commission Concluded

Outputs

Publications

Book chapter

Ana Carolina Marques; Hugo Águas; Rodrigo Martins; Bruno Costa-Silva; Maria Goreti Sales; Elvira Fortunato. "Surface-enhanced Raman scattering paper-based analytical devices". 117-167. Elsevier, 2022.
10.1016/b978-0-12-820534-1.00001-3

Journal article

Patrícia Amorim Gomes; Cristian Bodo; Carlos Nogueras-Ortiz; Martina Samiotaki; Minghao Chen; Carina Soares-Cunha; Joana Silva; et al. "A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology". Cell Communication and Signaling 21 1 (2023): http://dx.doi.org/10.1186/s12964-023-01045-z.
10.1186/s12964-023-01045-z
Inês Figueira; Paulo Bastos; Antonio González-Sarrías; Juan Carlos Espín; Bruno Costa-Silva; Claudia Nunes dos Santos. "Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?". Food & Function 14 1 (2023): 15-31. http://dx.doi.org/10.1039/d2fo00876a.
10.1039/d2fo00876a
Patrícia Gomes; Foteini Tzouanou; Konstantina Skolariki; Anastasia Vamvaka-Iakovou; Carlos Noguera-Ortiz; Katerina Tsirtsaki; Clarissa L. Waites; et al. "Extracellular vesicles and Alzheimer’s disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment". Experimental Neurology 358 (2022): 114183-114183. http://dx.doi.org/10.1016/j.expneurol.2022.114183.
10.1016/j.expneurol.2022.114183
Rune Matthiesen; Paula Gameiro; Andreia Henriques; Cristian Bodo; Maria Carolina Strano Moraes; Bruno Costa-Silva; José Cabeçadas; et al. "Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232113327.
10.3390/ijms232113327
Nuno Couto; Julia Elzanowska; Joana Maia; Silvia Batista; Catarina Esteves Pereira; Hans Christian Beck; Carvalho AS; et al. "IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer". Cells 11 18 (2022): 2800-2800. http://dx.doi.org/10.3390/cells11182800.
10.3390/cells11182800
Teresa Faria Pais; Hajrabibi Ali; Joana Moreira da Silva; Nadia Duarte; Rita Neres; Chintan Chhatbar; Rita C Acúrcio; et al. "Brain endothelial STING1 activation by Plasmodium -sequestered heme promotes cerebral malaria via type I IFN response". Proceedings of the National Academy of Sciences 119 36 (2022): http://dx.doi.org/10.1073/pnas.2206327119.
10.1073/pnas.2206327119
"Multiple Myeloma-Derived Extracellular Vesicles Modulate the Bone Marrow Immune Microenvironment". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.909880.
10.3389/fimmu.2022.909880
"Defining Optimal Conditions for Tumor Extracellular Vesicle DNA Extraction for Mutation Profiling". Cancers 14 13 (2022): 3258-3258. http://dx.doi.org/10.3390/cancers14133258.
10.3390/cancers14133258
"Patient-Derived Extracellular Vesicles Proteins as New Biomarkers in Multiple Myeloma - A Real-World Study". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.860849.
10.3389/fonc.2022.860849
Cristina Almeida; Ana L Teixeira; Francisca Dias; Vera Machado; Mariana Gomes Morais; Gabriela Martins; Carlos Palmeira; et al. "Extracellular Vesicles Derived-LAT1 mRNA as a Powerful Inducer of Colorectal Cancer Aggressive Phenotype". Biology (2022): https://www.mdpi.com/2079-7737/11/1/145.
10.3390/biology11010145
Catarina M. Abreu; Bruno Costa-Silva; Rui L. Reis; Subhas C. Kundu; David Caballero. "Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer". Lab on a Chip (2022): https://doi.org/10.1039/D2LC00006G.
10.1039/D2LC00006G
Ana Sofia Carvalho; Henrique Baeta; Andreia F. A. Henriques; Mostafa Ejtehadifar; Erin M. Tranfield; Ana Laura Sousa; Ana Farinho; et al. "Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping". International Journal of Molecular Sciences 22 20 (2021): 11004-11004. https://doi.org/10.3390/ijms222011004.
10.3390/ijms222011004
Luis Enrique Cortés-Hernández; Zahra Eslami-S; Bruno Costa-Silva; Catherine Alix-Panabières. "Current Applications and Discoveries Related to the Membrane Components of Circulating Tumor Cells and Extracellular Vesicles". Cells (2021): https://doi.org/10.3390/cells10092221.
10.3390/cells10092221
Cheila Brito; Bruno Costa-Silva; Duarte C. Barral; Marta Pojo. "Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22179260.
10.3390/ijms22179260
Inês Figueira; Joana Godinho-Pereira; Sofia Galego; Joana Maia; János Haskó; Kinga Molnár; Rui Malhó; et al. "MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22105214.
10.3390/ijms22105214
Costa-Silva, Bruno. "Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.592518.
10.3389/fcell.2020.592518
Carvalho AS; Maria Carolina Strano Moraes; Chan Hyun Na; Ivo Fierro-Monti; Andreia Almeida Henriques; Sara Zahedi; Cristian Bodo; et al. "Is the Proteome of Bronchoalveolar Lavage Extracellular Vesicles a Marker of Advanced Lung Cancer?". Cancers (2020): https://www.mdpi.com/2072-6694/12/11/3450.
10.3390/cancers12113450
Costa-Silva, Bruno. "Employing Flow Cytometry to Extracellular Vesicles Sample Microvolume Analysis and Quality Control". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.593750.
10.3389/fcell.2020.593750
Julia Elzanowska; Christine Semira; Bruno Costa-Silva. "DNA in extracellular vesicles: biological and clinical aspects". Molecular Oncology (2020): https://doi.org/10.1002/1878-0261.12777.
10.1002/1878-0261.12777
Costa-Silva, Bruno. "Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers". Cell 182 4 (2020): 1044-1061.e18. http://dx.doi.org/10.1016/j.cell.2020.07.009.
10.1016/j.cell.2020.07.009
Francisca Dias; Ana Luísa Teixeira; Inês Nogueira; Mariana Morais; Joana Maia; Cristian Bodo; Marta Ferreira; et al. "Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease". Cancers (2020): https://www.mdpi.com/2072-6694/12/6/1450.
10.3390/cancers12061450
Francisca Dias; Ana L Teixeira; Inês Nogueira; Mariana Gomes Morais; Joana Maia; Cristian Bodo; Marta Ferreira; et al. "Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/13/4624.
10.3390/ijms21134624
Costa-Silva, Bruno. "Liquid biopsies for multiple myeloma in a time of precision medicine". Journal of Molecular Medicine (2020): http://dx.doi.org/10.1007/s00109-020-01897-9.
10.1007/s00109-020-01897-9
Matthiesen, Rune. "Extra-cellular vesicles carry proteome of cancer hallmarks". Frontiers in Bioscience 25 3 (2020): 398-436. http://dx.doi.org/10.2741/4811.
10.2741/4811
Costa-Silva, Bruno. "The Gastrointestinal Tumor Microenvironment: An Updated Biological and Clinical Perspective". Journal of Oncology (2019): http://dx.doi.org/10.1155/2019/6240505.
10.1155/2019/6240505
Costa-Silva, Bruno. "Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis". Nature Cell Biology (2019): http://dx.doi.org/10.1038/s41556-019-0404-4.
10.1038/s41556-019-0404-4
Silva, Bruno. "Label-free nanosensing platform for breast cancer exosome profiling". ACS Sensors (2019): http://dx.doi.org/10.1021/acssensors.9b00760.
10.1021/acssensors.9b00760
Inês Santiago; João Santinha; Andrada Ianus; Antonio Galzerano; Rita Theias; Joana Maia; Maria J. Barata; et al. "Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes". Cancer Research 79 9 (2019): 2435-2444. https://doi.org/10.1158/0008-5472.CAN-18-3682.
10.1158/0008-5472.CAN-18-3682
Silva, Bruno. "Exosomes as emerging players in cancer biology". Biochimie (2018): http://dx.doi.org/10.1016/j.biochi.2018.03.006.
10.1016/j.biochi.2018.03.006
Silva, Bruno. "Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer". HPB (2018): http://dx.doi.org/10.1016/j.hpb.2017.12.010.
10.1016/j.hpb.2017.12.010
Silva, Bruno. "Exosome-Based Cell-Cell Communication in the Tumor Microenvironment". Frontiers in Cell and Developmental Biology (2018): http://dx.doi.org/10.3389/fcell.2018.00018.
10.3389/fcell.2018.00018
Peinado, H.; Zhang, H.; Matei, I.R.; Costa-Silva, B.; Hoshino, A.; Rodrigues, G.; Psaila, B.; et al. "Pre-metastatic niches: Organ-specific homes for metastases". Nature Reviews Cancer 17 5 (2017): 302-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015629030&partnerID=MN8TOARS.
10.1038/nrc.2017.6
Melo, F.R.; Bressan, R.B.; Costa-Silva, B.; Trentin, A.G.. "Effects of Folic Acid and Homocysteine on the Morphogenesis of Mouse Cephalic Neural Crest Cells In Vitro". Cellular and Molecular Neurobiology 37 2 (2017): 371-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-84970939851&partnerID=MN8TOARS.
10.1007/s10571-016-0383-y
de Lacerda, T.C.S.; Costa-Silva, B.; Giudice, F.S.; Dias, M.V.S.; de Oliveira, G.P.; Teixeira, B.L.; dos Santos, T.G.; Martins, V.R.. "Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells". Clinical and Experimental Metastasis 33 5 (2016): 441-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964426890&partnerID=MN8TOARS.
10.1007/s10585-016-9788-8
Costa-Silva, B.; Aiello, N.M.; Ocean, A.J.; Singh, S.; Zhang, H.; Thakur, B.K.; Becker, A.; et al. "Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver". Nature Cell Biology 17 6 (2015): 816-826. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930170395&partnerID=MN8TOARS.
10.1038/ncb3169
Lopes, M.H.; Santos, T.G.; Rodrigues, B.R.; Queiroz-Hazarbassanov, N.; Cunha, I.W.; Wasilewska-Sampaio, A.P.; Costa-Silva, B.; et al. "Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival". Oncogene 34 25 (2015): 3305-3314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934945282&partnerID=MN8TOARS.
10.1038/onc.2014.261
Hoshino, A.; Costa-Silva, B.; Shen, T.-L.; Rodrigues, G.; Hashimoto, A.; Tesic Mark, M.; Molina, H.; et al. "Tumour exosome integrins determine organotropic metastasis". Nature 527 7578 (2015): 329-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947723880&partnerID=MN8TOARS.
10.1038/nature15756
Thakur, B.K.; Zhang, H.; Becker, A.; Matei, I.; Huang, Y.; Costa-Silva, B.; Zheng, Y.; et al. "Double-stranded DNA in exosomes: A novel biomarker in cancer detection". Cell Research 24 6 (2014): 766-769. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901842265&partnerID=MN8TOARS.
10.1038/cr.2014.44
Hajj, G.N.M.; Arantes, C.P.; Dias, M.V.S.; Roffé, M.; Costa-Silva, B.; Lopes, M.H.; Porto-Carreiro, I.; et al. "The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles". Cellular and Molecular Life Sciences 70 17 (2013): 3211-3227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882453351&partnerID=MN8TOARS.
10.1007/s00018-013-1328-y
Peinado, H.; Aleckovic, M.; Lavotshkin, S.; Matei, I.; Costa-Silva, B.; Moreno-Bueno, G.; Hergueta-Redondo, M.; et al. "Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET". Nature Medicine 18 6 (2012): 883-891. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862007577&partnerID=MN8TOARS.
10.1038/nm.2753
Santos, T.G.; Silva, I.R.; Costa-Silva, B.; Lepique, A.P.; Martins, V.R.; Lopes, M.H.. "Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible protein 1 with the prion protein". Stem Cells 29 7 (2011): 1126-1136. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960075550&partnerID=MN8TOARS.
10.1002/stem.664
Mendes-de-Aguiar, C.B.N.; Alchini, R.; Zucco, J.K.; Costa-Silva, B.; Decker, H.; Alvarez-Silva, M.; Tasca, C.I.; Trentin, A.G.. "Impaired astrocytic extracellular matrix distribution under congenital hypothyroidism affects neuronal development in vitro". Journal of Neuroscience Research 88 15 (2010): 3350-3360. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649419983&partnerID=MN8TOARS.
10.1002/jnr.22481
Costa-Silva, B.; da Costa, M.C.; Melo, F.R.; Neves, C.M.; Alvarez-Silva, M.; Calloni, G.W.; Trentin, A.G.. "Fibronectin promotes differentiation of neural crest progenitors endowed with smooth muscle cell potential". Experimental Cell Research 315 6 (2009): 955-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-61849094246&partnerID=MN8TOARS.
10.1016/j.yexcr.2009.01.015
Mendes-De-Aguiar, C.B.N.; Costa-Silva, B.; Alvarez-Silva, M.; Tasca, C.I.; Trentin, A.G.. "Thyroid hormone mediates syndecan expression in rat neonatal cerebellum". Cellular and Molecular Neurobiology 28 6 (2008): 795-801. http://www.scopus.com/inward/record.url?eid=2-s2.0-52949141505&partnerID=MN8TOARS.
10.1007/s10571-008-9260-7

Other

Other output

Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait. Journal of Proteome Research. 2021. Inês Ferreira; Rita Machado de Oliveira; Ana Sofia Carvalho; Hans Christian Beck; Rune Matthiesen; Bruno Costa-Silva; Maria Paula Macedo; Akiko Teshima. https://doi.org/10.1101/2021.02.19.431856.
10.1101/2021.02.19.431856

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019	Exosomes as emerging players in cancer biology and diagnostic applications	2019 Molecular Diagnostics Europe (Lisbon, Portugal)
2019	Extracellular Vesicles as emerging players in Tumor Biology	2019 Annual Scientific Meeting of the European Society for Clinical Investigation (Coimbra, Portugal)
2019	Exosomes-based cell-cell communication role in metastatic organotropism	2019 Else Kröner-Fresenius-Stiftung Symposium: Novel concepts in niche-directed cancer therapies (Frankfurt, Germany)
2019	Exosomes-based liquid biopsies	2019 European Organization for Research and Treatment of Cancer Meeting – Gynecological cancer group (Lisboa, Portugal)
2018	Population Analysis of Extracellular Vesicles	Exosomes/Microvesicles: Heterogeneity, Biogenesis, Function and Therapeutic Developments. Keystone Symposia (Beckenridge, United States)
2017	Tumour exosomes – determination of organotropic metastases	2017 European Conference on Interventional Oncology (Bilbao, Spain)
2017	Novel cell-cell communication networks in organotropic metastasis	2017 International Symposium of Young Scientists in Cancer Research (Berlin, Germany)
2016	On the origin of metastasis in the liver	2016 Workshop: The liver beyond surgery in colorectal metastatic disease (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019/01/01 - Current	Defining Optimal Conditions for Tumor Extracellular Vesicle DNA Extraction for Mutation Profiling Supervisor of Julia Elzanowska	Molecular Biosciences (PhD) Instituto de Tecnologia Química e Biológica António Xavier, Portugal Fundação Champalimaud, Portugal
2016/03/23 - Current	IgG+ Extracellular Vesicles measure therapeutic response in advanced pancreatic cancer Supervisor	Clinical Investigation (PhD) Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal
2017/09/13 - 2022/03/23	NANOBIOSENSING PLATFORMS WITH SERS AND MIPBASED TECHNOLOGIES Co-supervisor	NANOCIÊNCIAS E NANOTECNOLOGIAS (PhD) Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal
2016/11/13 - 2022/03/04	The role of extracellular vesicles in multiple myeloma Co-supervisor	Clinical Investigation (PhD) Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal
2016/02/01 - 2021/05/25	Extracellular Vesicles: new population analysis methods and their role as messengers in tumor-stroma communication Supervisor	Biologia Básica e Aplicada (PhD) Universidade do Porto, Portugal Fundação Champalimaud, Portugal
2016/07/06 - 2021/01/27	Extracellular vesicles: agents of gut communication in prediabetes scenario Co-supervisor	Bioengenharia – Terapias Celulares e Medicina Regenerativa (PhD) Universidade de Lisboa, Portugal Fundação Champalimaud, Portugal
2016/09/14 - 2017/12/14	Functional characterization of tumour-derived exosomes in the zebrafish xenograft model Supervisor	Biologia Evolutiva e do Desenvolvimento (Master) Universidade de Lisboa, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019	New devices to monitor oxidative stress biomarkers in point-of-care: a new tool for cancer prevention	Gabriela Ferreira de Vasconcelos Martins (PhD)
2019	Responses to liver damage: Macrophage plasticity in tissue recovery and dysbiotic drifts	Inês Couto Coelho (PhD) Instituto Gulbenkian de Ciência, Portugal
2019	DEVELOPMENT OF A NANOBIT®-BASED CELLULAR SYSTEM TO CHARACTERIZE PROTACS IN LIVE KINETIC ASSAYS	Inês Graça Raposo (Master)
2019	MECHANISMS UNDERLYING EXOSOMAL TRAFFICKING OF THE ANTIRETROVIRAL FACTOR APOBEC3G: IMPLICATIONS FOR THE CONTAINMENT AND ERADICATION OF HIV-1 INFECTION	Afonso Machado Mendes (Master)
2017	¿Np63 is Critical for Progression of High Grade Non-Muscle Invasive Bladder Cancer Through Deregulation of Specific Genetic Pathways	Andreia Filipa Garrido Maia (Master)
2016	ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction (Thesis) Arguer	Sara Filipa Castro da Costa Pinto (Master)

Committee member

	Activity description Role	Institution / Organization
2022/04/29 - Current	Concurso para Atribuição de Bolsas de Investigação para Doutoramento 2022 (Biomedicina) - FCT Member
2016 - 2019	Colloquium Committee Member Member	Fundação Champalimaud, Portugal

Conference scientific committee

	Conference name	Conference host
2022/06/01 - 2022/06/30	5th ASPIC International Congress	IPO Porto

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2018 - 2018	Evaluation Committee for a position of Research Assistant Evaluator

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2018/11	Entrevista à Revista Sábado sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.	Revista Sábado
2018/02	Entrevista à Revista Sábado sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.	Revista Sábado
2017/11	Entrevista à Revista Sábado sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.	Revista Sábado

Interview (tv / radio show)

	Program	Topic
2018/02 - Current	Entrevista à TV Bandeirantes - Brasil (Jornal da Band) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.
2017/09 - Current	Entrevista à Antena 1 (90 segundos de ciência) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.
2017/06 - Current	Entrevista à TVI (Jornal da Uma) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.
2017/06 - Current	Entrevista à RTP (Bom dia Portugal) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.

Journal scientific committee

	Journal title (ISSN)	Publisher
2019 - Current	Science
2019 - Current	Analytical Chemistry
2019 - Current	Frontiers in Immunology
2019 - Current	Experimental Cell Research
2019 - Current	International Journal of Molecular Sciences
2019 - Current	Journal of Experimental & Clinical Cancer Research
2019 - Current	Molecular Oncology
2019 - Current	Cancers
2018 - Current	The Breast
2018 - Current	Proteome
2018 - Current	Oncogene
2017 - Current	Journal of Extracellular Vesicles
2017 - Current	Journal of Cell Communication and Signaling
2017 - Current	Pancreas
2017 - Current	Molecular Oncology
2017 - Current	eLife
2016 - Current	Journal of Clinical Investigation
2015 - Current	Brazilian Journal of Medical and Biological Research
2014 - Current	Journal of Neuroscience Research

Mentoring / Tutoring

	Topic	Student name
2019 - Current		Helena Gouveia, MD
2018 - Current		Christine Semira, MD
2018 - Current		Julia Elzanowska, MSc
2017 - Current		Nuno Couto, MD
2016 - Current		Joana Maia, MSc (GABBA Fellowship - PD/BD/105866/2014)

Distinctions

Award

2017	Prémio Crioestaminal