Patrícia Silva (4B19-7E26-A047)

Curriculum Vitae

Patrícia Silva

Patrícia Silva is a Research Assistant and integrated member of the Oral Pathology and Rehabilitation Research Unit (UNIPRO) at the University Institute of Health Sciences (IUCS) at CESPU. She is also an Invited Assistant Professor of Human Body Morphology and Functions, and a lecturer in the Oncobiology Advanced Course at the same institution. She is a collaborating researcher at the One Health Toxicology Research Unit (1H-TOXRUN, IUCS-CESPU), where she is a member of the Office of Communication and Public Engagement and the Bibliometric & Financing Office. She completed a pre-Bologna degree in Pathological, Cytological, and Thanatological Anatomy (CESPU) in 2008 and a master¿s degree in Molecular Biology Techniques and Cytomics in Health Science (CESPU) in 2011. In 2017, she completed her PhD in Biomedical Sciences (FCT fellowship SFRH/BD/90744/2012) at the Department of Biomedical Sciences and Medicine at the University of Algarve (Ualg), where she investigated the function, regulation, and therapeutic implications of the Mitotic Checkpoint mechanism. Her PhD research was conducted at the Centre for Biomedical Research (CBMR, Ualg) in collaboration with CESPU. She has previously worked as a pathology anatomy technician at IPATIMUP, and at INEB, where she processed biological samples from mice to evaluate heart injury. Currently, her research interests include the clinical relevance of mitosis regulation and the development of strategies to induce cancer cell death or enhance their sensitivity to current chemotherapeutics agents. She maintains collaborative work with the Faculty of Pharmacy of the University of Porto (FFUP) to characterize small molecules with anti-cancer potential. Recently, she co-authored a book entitled "Mas... o que é o cancro?," with the objective of explaining heath concepts to preschoolers. She has been interested in developing research in the field of health literacy, particularly for early ages. She has published 39 articles in international peer-reviewed journals, mostly in Q1. Additionally, she has authored/co-authored 29 invited/selected talks at national and international meetings, been involved in 22 projects with competitive funding (FCT, Norte2020, CESPU), and co-supervised 20 MSc and graduated students and 2 PhD students.

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Identification

Personal identification

Full name: Patrícia Silva
Date of birth: 1986/01/01
Gender: Female

Citation names

Silva, Patrícia M. A.

Author identifiers

Ciência ID: 4B19-7E26-A047
ORCID iD: 0000-0002-0694-7321
Researcher Id: AAR-5774-2021
Scopus Author Id: 55855611900

Email addresses

patricia.silva@cespu.pt (Professional)

Telephones

Telephone

224 157 Ext.: 189 (Professional)

Addresses

Rua Central de Gandra, 1317, 4585-116, Gandra, Paredes, Portugal (Professional)

Websites

https://toxrun.iucs.cespu.pt/ (Professional)
https://unipro.iucs.cespu.pt/ (Professional)
https://www.cespu.pt/ (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Medical and Health Sciences - Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Elementary (A2)	Upper intermediate (B2)	Elementary (A2)	Advanced (C1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Elementary (A2)	Beginner (A1)

Education

	Degree	Classification
2022/03/13 - 2022/03/16 Concluded	From 3D light to 3D electron microscopy (virtual) (Outros) European Molecular Biology Laboratory, Germany
2022/01/20 - 2022/02/17 Concluded	Course in Internal Quality Audits - ISO 9001 (Outros) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2021/07/22 - 2021/07/23 Concluded	Course in Online Survey Construction (Using LimeSurvey) (Outros) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2020/05/08 - 2020/05/22 Concluded	Workplace Safety - COVID-19 Prevention Measures (Outros) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2019/11/04 - 2019/12/21 Concluded	Course in Editing and Processing Scientific Images using GIMP (Outros) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2019/12/12 - 2019/12/12 Concluded	Course in Integrated Management of Hospital Waste - Module I (Outros) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2019/11/25 - 2019/12/12 Concluded	Course in Creative and Traditional Management of Bibliographic References using Zotero and Mendeley (Outros) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/05/07 - 2018/05/19 Concluded	Course in Laboratory Animal Science - Category C (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01 - 2017/09/15 Concluded	Biomedical Sciences (Doutoramento) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal "The Spindle Assembly Checkpoint: New Insights Into Its Function, Regulation and Therapeutic Implications" (THESIS/DISSERTATION)	Aprovado por unanimidade com distinção e louvor
2016/11/28 - 2016/12/02 Concluded	II Quantitative Fluorescence Microscopy Course (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/01/06 - 2014/01/17 Concluded	Biostatistics in Health Sciences Course, 4th Edition (Outros) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/12/02 - 2013/12/05 Concluded	Proteomics course: gel based protein separation by twodimensional gel electrophoresis and protein characterization by MALDI-TOF/TOF mass spectrometry. (Outros) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2008 - 2011/09/09 Concluded	Molecular Biology and Cytomics Techniques in Health Sciences (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal "Relação entre a proteína Bub3 do checkpoint mitótico e a proteína motora Dineína durante o alinhamento dos cromossomas na placa metafásica" (THESIS/DISSERTATION)	19 out of 20
2010/10/15 - 2010/10/30 Concluded	Cytopathology Continuous Learning Course (Outros) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2008/04/11 - 2008/04/12 Concluded	I Advanced Course in Forensic Entomology (Outros) Universidade do Porto Faculdade de Direito, Portugal Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal
2004 - 2008 Concluded	Pathological, Cytological, and Thanatological Anatomy (Licenciatura) Major in Não Aplicável Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	16 out of 20
2007/06/05 - 2007/07/05 Concluded	Criminal Investigation Synthetic Course (Outros) Universidade Fernando Pessoa, Portugal

Affiliation

Science

	Category Host institution	Employer
2024/03 - Current	Auxiliary Researcher (Research)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Patologia e Reabilitação Oral, UNIPRO (IUCS-CESPU)), Portugal
2021 - Current	Researcher (Research)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2021 - 2024/03	Research Assistant (Research)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
	UNIPRO – Unidade de Investigação em Patologia e Reabilitação Oral, Instituto Universitário de Ciências da Saúde (IUCS-CESPU), Portugal
2019 - 2021	Research Assistant (Research)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
	Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2024/09 - Current	Invited Assistant Professor (University Teacher)	Instituto Politécnico de Saúde do Norte - Campus de Famalicão, Portugal

2019 - Current	Invited Assistant Professor (University Teacher)	Instituto Universitário de Ciências da Saúde, Portugal

2008 - 2019	Invited Assistant (University Teacher)	Instituto Universitário de Ciências da Saúde, Portugal

Other Careers

	Category Host institution	Employer
2009/04 - 2011/02	Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Anatomia Patológica, Citológica e Tanatológica)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010/03 - 2010/12	Auxiliar de Preparação de Anatomia Patológica (Técnico de Diagnóstico e Terapêutica - Técnico de Anatomia Patológica, Citológica e Tanatológica)	Instituto Nacional de Engenharia Biomédica, Portugal
	Instituto Nacional de Engenharia Biomédica, Portugal

Positions / Appointments

	Category Host institution	Employer
2024 - Current	Topical Advisory Panel member of the "International Journal of Biomedical Sciences" journal	MDPI AG, Switzerland

2021/04 - Current	Topical Advisory Panel member of the "Pharmaceutics" journal	MDPI AG, Switzerland

2021 - Current	Team member of the Office of Communication and Public Engagement (OCPE) of the One Health Toxicology Research Unit (1H-TOXRUN) (https://toxrun.iucs.cespu.pt/?q=content/office-communication-and-public-	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal

2021 - Current	Team member of the Bibliometric & Financing Office of the One Health Toxicology Research Unit (1H-TOXRUN) (https://toxrun.iucs.cespu.pt/?q=content/bibliometric-financing-office)	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal

2023/06/01 - 2023/06/02	Editorial Council member of Scientific Letters [2795-5117] - Production Editor of the Book of Abstracts for the II UNIPRO International Congress (1(Sup 2). https://doi.org/10.48797/sl.2023.112)	Scientific Letters, Portugal

2023/04/27 - 2023/04/28	Editorial Council member of Scientific Letters [2795-5117] - Production Editor of the Book of Abstracts for the II TOXRUN International Congress (1(Sup 1). https://doi.org/10.48797/sl.2023.111	Scientific Letters, Portugal

Others

	Category Host institution	Employer
2017 - 2021	Editor of IINFACTS News	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
	Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2017 - 2018	Técnica Superior de Investigação (Técnica Superior)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
	Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2011 - 2011	Técnica Superior de Investigação (Técnica Superior)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Projects

Grant

	Designation	Funders
2013 - 2017/09	The Spindle Assembly Checkpoint: New Insights Into Its Function, Regulation and Therapeutic Implications. SFRH/BD/90744/2012 PhD Student Fellow Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal	Fundação para a Ciência e Tecnologia (FCT) Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal INESC Microsistemas e Nanotecnologias, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024/04 - 2025/04	Sneaking Around Science: Promoting Health Scientific Literacy in Preschool SciPre.com_GI2- CESPU-2023 Principal investigator Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal UNIPRO – Unidade de Investigação em Patologia e Reabilitação Oral, Instituto Universitário de Ciências da Saúde (IUCS-CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Ongoing
2024/04 - 2025/04	Boosting the Efficacy of Emerging Mitosis-targeted Antitumor Therapies BeatCancer_GI2- CESPU-2023 Co-Principal Investigator (Co-PI) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal UNIPRO – Unidade de Investigação em Patologia e Reabilitação Oral, Instituto Universitário de Ciências da Saúde (IUCS-CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Ongoing
2024 - 2025	Screening and unraveling the mechanism of action of chiral flavonoid derivatives with anticancer activity. FlavScreen_GI2-CESPU-2023 Researcher Instituto Universitário de Ciências da Saúde Unidade de Investigação em Patologia e Reabilitação Oral, UNIPRO (IUCS-CESPU)), Portugal	Ongoing
2020/01/01 - 2024/12/31	Applied Molecular Biosciences Unit UIDP/04378/2020 10.54499/UIDP/04378/2020 Universidade Nova de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2024/12/31	Applied Molecular Biosciences Unit UIDB/04378/2020 10.54499/UIDB/04378/2020 Universidade Nova de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/09/01 - 2023/08/31	Overcoming paclitaxel resistance in ovarian cancer upPTXovcar-GI2-CESPU-2022 Principal investigator Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2022/09/01 - 2023/08/31	The second-generation antimitotics: a second chance? SGA4Cancer-GI2-CESPU-2022 Co-Principal Investigator (Co-PI) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2022/09/01 - 2023/08/31	Studies of molecular mechanisms of flavonoid derivatives with potential antitumor activity Flav4Tumor-GI2-CESPU-2022 Researcher Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Ongoing
2021 - 2022	Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents. AntiMitoSphere_APSFCT_IINFACTS_2021 Researcher Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Ongoing
2021 - 2022	Antitumor and antimicrobial activities of chiral derivatives of xanthones and flavonoids. ActivCHIRAL_PI2RL_IINFACTS_2021 Researcher Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Ongoing
2018/09/01 - 2022	Molecular mechanisms of chromosome segregation POCI-01-0145-FEDER-030014 Researcher Universidade do Algarve Centro de Investigação em Biomedicina, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal Centro de Ciências do Mar, Portugal	Fundação para a Ciência e Tecnologia (FCT) Concluded
2019 - 2021	Biological assessment of debris from oral implants IMPLDEBRIS-PI-3RL-IINFACTS-2019 Researcher	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
2019 - 2021	Chiral derivatives of xanthones and flavonoids: synthesis and biological activity evaluation. CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019: Researcher Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Ongoing
2019 - 2021	Chiral derivatives of xanthones and flavonoids: synthesis and biological activity evaluation. CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019: Researcher Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	N/A
2019 - 2020	Targeting the mitotic protein p31comet for cancer therapy ComeTax-PFT-IINFACTS-2019 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2018 - 2019	Bub3 and Spindly knockout mediated by CRISPR-Cas9 technology: in vitro characterization and therapeutic potential CRISPRTech-CESPU-2018 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário Concluded
2018 - 2019	Evaluation of Biologic effects of Laser Treatment of Benign and Potentially Malignant Diseases in Oral Cavity LASERORAL-CESPU-2018 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2017/04 - 2018/04	Relating Monocarboxylate Transporters (MCTs) Expression to Macrophage Polarization in Oral Squamous Cell Carcinoma MacrOral Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2017/04 - 2018/04	BubR1 as Predictive Biomarker of Malignant Transformation of Oral Potentially Malignant Disorders BubOral_CESPU2017 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
2017 - 2018	Anticancer activity of aromatic plant extracts and main terpenoids, synergy with conventional chemotherapeutics AntiCancerAromTerpen_CESPU_2017 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2016 - 2018	Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents. PTDC/MAR-BIO/4694/2014 Researcher Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e Tecnologia (FCT)
2016 - 2017	Clinicopathological significance of mitotic protein expression in oral cancer. MitOralC-CESPU-2016 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2016 - 2017	The mitotic protein Spindly as a cancer therapeutic target SpindlyTarget-CESPU-2016 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2014 - 2015	Therapeutic targeting of the mitotic checkpoint to increase sensitivity of cancer cells to anti-mitotic agents. CheckTax-CESPU-2014 Researcher	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2014 - 2015	Characherisation of HER family heterodimers in oral squamous cell carcinomas using in situ proximity ligation assay HerPLA-CESPU-2014 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) Concluded
2011 - 2015	Human Papiloma Virus (HPV) as etiologic agent of oral cancer 05-GCD-CICS-2011 Researcher Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)

Outputs

Publications

Book	Pinto, Bárbara; Torres, Diana; Silva, Patrícia M. A.. Mas...o que é o cancro?. Portugal: Flamingo Ediçoes, Atlantic Books. 2024. Published
Book chapter	Silva, Patrícia M. A.; Silva, João P. N.; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Time-lapse Imaging to Analyze Cell Fate in Response to Antimitotics.". In Methods in Molecular Biology. New York, United States: Springer Nature, 2024. Accepted
Conference poster	Francisca Sampaio; Carina Gomes; João P. N. Silva; Bousbaa, Hassan; Silva, Patrícia M. A.. Corresponding author: Silva, Patrícia M. A.. "KSP and MPS1 kinases as potential therapeutic targets for ovarian cancer. https://doi.org/10.48797/sl.2024.203". Paper presented in III 1H-TOXRUN International Congress 2024, 2024. João P.N. Silva; Raquel Silva; Maria do Carmo vilas-Boas; Silva, Patrícia M. A.; Bousbaa, Hassan. "KSP and Aurora B as potential biomarkers and therapeutic targets for head and neck cancer. https://doi.org/10.48797/sl.2024.204". Paper presented in III 1H-TOXRUN International Congress 2024, 2024. Bárbara Pinto; Silva, Patrícia M. A.; Bruno Sarmento; Juliana Carvalho-Tavares; Hassan Bousbaa. "Developing robust heterotypic 3D lung cancer cultures for drug screening: preliminary results. https://doi.org/10.48797/sl.2024.228". Paper presented in III 1H-TOXRUN International Congress 2024, 2024. João P. N. Silva; Silva, Patrícia; Luís Monteiro ; Bousbaa, Hassan. "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells". Paper presented in PhD Day 2023 - IUCS-CESPU \| "The Impact of Science: How Research Shapes Society?", 2023. Eliseba Castro; J. Moreira; Patrícia M. A. Silva; L. Saraiva; M. Pinto; H. Bousbaa; H. Cidade. "Biological evaluation of new diarylpentanoid analogues for antitumor activity". Paper presented in Trabalho apresentado em II TOXRUN International Congress. https://doi.org/10.48797/sl.2023.26, 2023. B. Pinto; P. Silva; B. Sarmento; J. Carvalho-Tavares; H. Bousbaa. "Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell killing in 2D and 3D culture systems". Paper presented in Trabalho apresentado em II TOXRUN International Congress, https://doi.org/10.48797/sl.2023.24, 2023. João P. N. Silva; L. Monteiro; Patrícia M.A. Silva; Bousbaa, Hassan. "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells". Paper presented in Trabalho apresentado em II TOXRUN International Congress. https://doi.org/10.48797/sl.2023.25, 2023. João P. N. Silva; Silva, Patrícia; Hassan Bousbaa. "Potenciando o efeito terapêutico do inibidor da EG5 numa combinação com Navitoclax em células de cancro oral". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2022. Silva, Patrícia; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Hassan Bousbaa. "INIBIÇÃO DA BUB3 + TRATAMENTO COM PACLITAXEL = UMA ESTRATÉGIA PROMISSORA PARA TRAVAR A PROLIFERAÇÃO CELULAR NO GLIOBLATOMA MULTIFORME". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2022. Marta Pereira; Patrícia M. A. Silva; Bousbaa, Hassan. "IMPROVING THE ANTITUMORAL ACTIVITY OF SECOND-GENERATION ANTIMITOTICS". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, 2022. Bárbara Fernandes Pinto; Patrícia M.A. Silva; Juliana Carvalho-Tavares; Bousbaa, Hassan.. "A INIBIÇÃO DA MPS-1 COMBINADA COM UM INDUTOR DA APOPTOSE POTENCIALIZA A ATIVIDADE ANTITUMORAL EM CULTURAS 2D E 3D DE CÉLULAS DE CANCRO DO PULMÃO". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, 2022. Delgado, Leonor; Monteiro, Luís; Patrícia M. A. Silva; Bousbaa, Hassan; Fernanda Garcez; Brilhante-Simões, Paula; Prada,. "BUBR1 AS A PROGNOSTIC BIOMARKER IN CANINE ORAL SQUAMOUS CELL CARCINOMA". Paper presented in 1º INTERNATIONAL CONGRESS OF UNIPRO RESEARCH UNIT (IUCS - CESPU), 2022. Pinto, Bárbara Fernandes; Silva, Patrícia M. A.; Juliana Carvalho-Tavares; Bousbaa, Hassan. "O Navitoclax potencializa os efeitos terapêuticos do inibidor da PLK-1 em culturas 2D e 3D de células de cancro de pulmão". Paper presented in 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2022. Durães, Fernando; Novais, Pedro; Silva, Patrícia M. A.; Esteves, Cátia I. C.; Guieu, Samuel; Bousbaa, Hassan; Pinto, Madalena; Sousa, Emília. "Antitumor activity and fluorescence of tetracyclic thioxanthenes: new theranostic agents?". Paper presented in 26th EFMC International Symposium in Medicinal Chemistry, 2021. Silva, Patrícia. "Antitumor activity and fluorescence of tetracyclic thioxanthenes: new therasnostics agents?". Paper presented in EFMC-ISMC, International Symposium on Medicinal Chemistry, 2021. Silva, Patrícia. "Synthesis of enantiomeric pure chiral derivatives of 4'-methylchrysoeriol.". Paper presented in IJUP 2020 - Encontro de Investigação Jovem da Univerisdade do Porto, 2020. Silva, Patrícia. "Xanthone derivatives as inhibitors of P-glycoprotein and of tumor cell growth: synthesis and biological evaluation.". Paper presented in 13th National Organic Chemistry Meeting (13ENQO) and the 6th National Medicinal Chemistry Meeting (6ENQT), 2020. Silva, Patrícia. "New chalcone derivatives with suitable drug-like lipophilicity targeting mitosis.". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019. Silva, Patrícia. "A inibição da molécula p31(comet) sensibiliza células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel.". Paper presented in Encontro Nacional de Jovens Investigadores em Oncologia, 2019. Silva, Patrícia. "Targeting p31(comet) sensitizes non-small cell lung cancer cells to paclitaxel treatment". Paper presented in GenomePT Symposium, 2019. Silva, Patrícia. "Carboxyxanthone derivatives: synthesis and effect on human tumor cell lines". Paper presented in 2th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018. Silva, Patrícia. "New chalcone derivatives: synthesis and antitumor activity evaluation.". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018. Silva, Patrícia. "Flavonoids targeting caspases: synthesis and antitumor activity evaluation". Paper presented in Trabalho apresentado em Italian-Spanish_Portuguese Joint Meeting in Medicinal Chemistry, MedChem, 17-20 July, Sicily 2018, Palermo, Italy., 2018. Silva, Patrícia. "2’,4’-Dihydroxy-3,4,5-Trimethoxychalcone Analogues: Synthesis, Biological Activity and Docking Studies". Paper presented in 12th YES (Young European Scientist) Meeting, 2017. Silva, Patrícia. "Synthesis, enantiomeric purity evaluation and enantioselectivity study on human tumor cell lines of new chiral derivatives of xanthones". Paper presented in 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17), 2017. Silva, Patrícia. "Spindly Expression in Oral Squamous Cell Carcinomas.". Paper presented in 6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO), 2017. Silva, Patrícia. "BubR1 as a potential biomarker of malignant transformation in oral leukoplakias". Paper presented in 6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO), 2017. Silva, Patrícia. "Heterocyclic Chalcone Derivatives: Synthesis, Antitumor Activity and Docking studies". Paper presented in IJUP 2017, 10º Encontro de Investigação Jovem da Universidade do Porto, 2017. Silva, Patrícia. "New Prenylated Chalcone Acting as an Antimitotic Agent and Inducing Mitotic Catastrophe in Human Breast Adenocarcinoma MCF-7 Cell Line". Paper presented in 2nd ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2016. Silva, Patrícia. "Targeting Spindly as Antimitotic Strategy to Induce Cancer Cell Death". Paper presented in 2nd ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2016. Silva, Patrícia. "Acetylated flavonoids and xanthones: synthesis and screening for antitumor activity". Paper presented in II Encontro Nacional de Estudantes de Química, 2015. Silva, Patrícia. "A new prenylated chalcone with anti-mitotic activity in cancer cell lines". Paper presented in XX Encontro Luso-Galego de Química, 2014. Silva, Patrícia. "Assessing the anti-mitotic activity of a new prenylated chalcone in cancer cell lines". Paper presented in INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, 2014. Silva, Patrícia. "Evaluating the prognostic value of BubR1 and Mad2 mitotic checkpoint protein expression in oral squamous cell carcinoma". Paper presented in INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, 2014. Silva, Patrícia. "Functional relationship between the mitotic checkpoint protein Bub3 and the molecular motor dynein in regulating kinetochore-micrtubule attachment". Paper presented in EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function, 2014. Silva, Patrícia. "Are Bub3 and Dynein in a relationship? Functional relationship between the mitotic checkpoint protein Bub3 and the molecular motor dynein in regulating kinetochore-microtubule attachment". Paper presented in Embo Young Scientists´Forum, 2013. Silva, Patrícia; Moura, I.M.B.; Delgado, M.L.; Silva, P.M.A.; Lopes, C.A.; do Amaral, J.B.; Monteiro, L.S.; Bousbaa, H.. "High CDC20 expression is associated with poor prognosis in oral squamous cell carcinoma". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013. 10.1111/jop.12115
Encyclopedia entry	Andrea Cunha , Patrícia M. A. Silva , Bruno Sarmento , Odília Queirós. "Targeting Glucose Metabolism to Overcoming Drug Resistance". In Scholarly Community Encyclopedia, MDPI, 2024. https://encyclopedia.pub/entry/54250. Published João P. N. Silva; Bárbara F. Pinto; Luís Monteiro; Patrícia M. A. Silva; Bousbaa, Hassan. Autor correspondente: Patrícia. "Combination Therapy to Fight Oral Cancer". In Scholarly Community Encyclopedia, MDPI, 2023. https://encyclopedia.pub/entry/45284.. Published Silva, Patrícia M. A.; Bousbaa, Hassan. "The Role of BUB3 in Human Cancers". In In Scholarly Community Encyclopedia. MDPI, 2022. https://encyclopedia.pub/entry/23283. Published Bárbara Pinto; Ana C. Henriques; Silva, Patrícia; Bousbaa, Hassan. "Three-Dimensional Spheroids in Cancer Research". , 2020. https://encyclopedia.pub/entry/3418. Published
Journal article	Barbosa, Daniel José; Barbosa, Joana; Souza-Fagundes, Elaine M.; Silva, Patrícia M. A.. "Editorial: The (un)desirability of cell death in health and disease: emerging modulators and their mechanisms". Frontiers in Cell and Developmental Biology 12 (2024): http://dx.doi.org/10.3389/fcell.2024.1523293. Published • 10.3389/fcell.2024.1523293 Almeida-Nunes, Diana Luísa; Silva, João P. N.; Nunes, Mariana; Silva, Patrícia M. A.; Silvestre, Ricardo; Dinis-Oliveira, Ricardo Jorge; Bousbaa, Hassan; Ricardo, Sara. "Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines". International Journal of Molecular Sciences 25 22 (2024): 11935. http://dx.doi.org/10.3390/ijms252211935. Published • 10.3390/ijms252211935 Calheiros-Lobo, Mafalda; Silva, João P. N.; Delgado, Leonor; Pinto, Bárbara; Monteiro, Luís; Lopes, Carlos; Silva, Patrícia M. A.; Bousbaa, Hassan. "Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer: A Plausible Alliance to Enhance Cell Death". Cancers 16 22 (2024): 3732. http://dx.doi.org/10.3390/cancers16223732. Published • 10.3390/cancers16223732 Silva, Helena Gomes; Sobral, Rómulo; Alhinho, Ana Teresa; Afonso, Hugo Ricardo; Ribeiro, Teresa; Silva, Patrícia M. A.; Bousbaa, Hassan; Morais-Cecílio, Leonor; Costa, Maria Manuela Ribeiro. "Genetic and epigenetic control of dormancy transitions throughout the year in the monoecious cork oak". Physiologia Plantarum 176 6 (2024): http://dx.doi.org/10.1111/ppl.14620. Published • 10.1111/ppl.14620 Calheiros-Lobo, Mafalda; Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. "Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer". Pharmaceutics 16 9 (2024): 1196. http://dx.doi.org/10.3390/pharmaceutics16091196. 10.3390/pharmaceutics16091196 Henriques, Ana C.; Silva, João P. N.; Pinto, Bárbara; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Exploring the Clinical Relevance of p31comet in Head and Neck Squamous Cell Carcinoma through UALCAN database analysis". Scientific Letters (2024): https://publicacoes.cespu.pt/index.php/sl/article/view/266. Published Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. "Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing". Cancers 16 11 (2024): 2014. http://dx.doi.org/10.3390/cancers16112014. Published • 10.3390/cancers16112014 Barbosa, Flávia; Araújo, Joana; Gonçalves, Virgínia M. F.; Palmeira, Andreia; Cunha, Andrea; Silva, Patrícia M. A.; Fernandes, Carla; et al. "Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids". International Journal of Molecular Sciences 25 4 (2024): 2121. http://dx.doi.org/10.3390/ijms25042121. Published • 10.3390/ijms25042121 Moreira, Joana; Silva, Patrícia M. A.; Castro, Eliseba; Saraiva, Lucília; Pinto, Madalena; Bousbaa, Hassan; Cidade, Honorina. "BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity". International Journal of Molecular Sciences 25 3 (2024): 1691. http://dx.doi.org/10.3390/ijms25031691. Published • 10.3390/ijms25031691 Silva, Patrícia M. A.; Henriques, Ana C.; Silva, João Pedro Nunes; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Targeting p31comet to Enhance Cisplatin-induced Cytotoxicity in Oral Squamous Cell Carcinoma Cells". Scientific Letters (2024): Published Pinto, Bárbara; Silva, João P. N.; Silva, Patrícia M. A.; Barbosa, Daniel José; Sarmento, Bruno; Tavares, Juliana Carvalho; Bousbaa, Hassan. "Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction". Pharmaceutics 16 1 (2023): 56. http://dx.doi.org/10.3390/pharmaceutics16010056. 10.3390/pharmaceutics16010056 Cunha, Andrea; Silva, Patrícia; Ana Catarina Rocha; Queiros, Odilia. "Unravelling the Warburg effect: glycolytic inhibitors as promising agents in cancer therapy". Scientific Letters 1 1 (2023): https://publicacoes.cespu.pt/index.php/sl/article/view/116. Open access • Published Cunha, Andrea; Silva, Patrícia M. A.; Sarmento, Bruno; Queirós, Odília. "Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance". Pharmaceutics 15 11 (2023): 2610. http://dx.doi.org/10.3390/pharmaceutics15112610. 10.3390/pharmaceutics15112610 João Silva; Bárbara Pinto; Luis Monteiro; Patrícia Silva; Hassan Bousbaa. "Combination Therapy as a Promising Way to Fight Oral Cancer". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/6/1653. 10.3390/pharmaceutics15061653 Joana Moreira; Patrícia Silva; Matilde Barros; Lucília Saraiva; Madalena M. M. Pinto; Hassan Bousbaa; Honorina Cidade. "Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/6/879. 10.3390/ph16060879 Maria Leonor Delgado; Luis Monteiro; Patrícia Silva; Hassan Bousbaa; Fernanda Garcez; João Silva; Paula Brilhante-Simões; Isabel Pires; Justina Prada. "BUBR1 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma". Animals (2022): https://www.mdpi.com/2076-2615/12/22/3082. 10.3390/ani12223082 Andrea Cunha; Ana Catarina Rocha; Flávia Barbosa; Ana Baião; Patrícia Silva; Bruno Sarmento; Odilia Queiros. "Glycolytic Inhibitors Potentiated the Activity of Paclitaxel and Their Nanoencapsulation Increased Their Delivery in a Lung Cancer Model". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/10/2021. 10.3390/pharmaceutics14102021 Pinto, Bárbara; Novais, Pedro; Henriques, Ana C.; Carvalho-Tavares, Juliana; Silva, Patrícia M. A.; Bousbaa, Hassan. "Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems". Pharmaceutics 14 6 (2022): 1209. http://dx.doi.org/10.3390/pharmaceutics14061209. 10.3390/pharmaceutics14061209 Silva, Patrícia M. A.; Bousbaa, Hassan. "BUB3, beyond the Simple Role of Partner". Pharmaceutics 14 5 (2022): 1084. http://dx.doi.org/10.3390/pharmaceutics14051084. 10.3390/pharmaceutics14051084 Bárbara Pinto; Catarina Pacheco; Silva, Patrícia M. A.; Juliana Carvalho-Tavares; Bruno Sarmento; Hassan Bousbaa. "Nanomedicine internalization and penetration: why should we use spheroids?". Scientific Letters (2022): Open access • Published Silva, Patrícia M. A.; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Hassan Bousbaa. "Targeting BUB3 in combination with paclitaxel inhibits proliferation of glioblastoma cells by enhancing cellular senescence". Scientific Letters (2022): https://publicacoes.cespu.pt/index.php/sl/article/view/11. Published Pedro Novais; Patrícia Silva; Joana Moreira; Andreia Palmeira; Isabel Amorim; Madalena M. M. Pinto; Honorina Cidade; Hassan Bousbaa. "BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/23/7139. 10.3390/molecules26237139 Nunes, Mariana; Silva, Patrícia M. A.; Coelho, Ricardo; Pinto, Carla; Resende, Albina; Bousbaa, Hassan; Almeida, Gabriela M.; Ricardo, Sara. "Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.752127. 10.3389/fonc.2021.752127 Pedro Novais; Patrícia Silva; Isabel Amorim; Hassan Bousbaa. "Second-Generation Antimitotics in Cancer Clinical Trials". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/7/1011. 10.3390/pharmaceutics13071011 Fernando Durães; Patrícia Silva; Pedro Novais; Isabel Amorim; Luis Gales; Cátia I. C. Esteves; samuel guieu; et al. "Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/11/3315. 10.3390/molecules26113315 Henriques AC; Silva PMA; Sarmento B; Bousbaa H. "Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic.". Scientific reports (2021): http://europepmc.org/abstract/med/33603057. 10.1038/s41598-021-83743-7 Henriques AC; Silva PMA; Sarmento B; Bousbaa H. "The Mad2-Binding Protein p31comet as a potential target for human cancer therapy.". Current cancer drug targets (2021): http://europepmc.org/abstract/med/33511944. 10.2174/1568009621666210129095726 Monteiro, L.; Silva, P.; Delgado, L.; Amaral, B.; Garcês, F.; Salazar, F.; Pacheco, JJ.; et al. "Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study". Medicina Oral Patología Oral y Cirugia Bucal (2021): e719-e728. http://dx.doi.org/10.4317/medoral.24511. 10.4317/medoral.24511 Fábio França; Patrícia Silva; José X. Soares; Ana C. Henriques; Daniela R. P. Loureiro; Carlos M. G. Azevedo; Carlos Afonso; Hassan Bousbaa. "A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel". Molecules (2020): https://www.mdpi.com/1420-3049/25/24/5845. 10.3390/molecules25245845 Pinto B; Henriques AC; Silva PMA; Bousbaa H. "Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research.". Pharmaceutics (2020): http://europepmc.org/abstract/med/33291351. 10.3390/pharmaceutics12121186 Carraro, Maria L.; Marques, Sandra; Silva, Ana Sofia; Freitas, Bruno; Silva, Patrícia M. A.; Pedrosa, Joel; De Marco, Paolo; et al. "Synthesis of New Chiral Derivatives of Xanthones with Enantioselective Effect on Tumor Cell Growth and DNA Crosslinking". ChemistrySelect 5 33 (2020): 10285-10291. http://dx.doi.org/10.1002/slct.202002588. 10.1002/slct.202002588 Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. "Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry 184 (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752. Published • 10.1016/j.ejmech.2019.111752 Silva, Patrícia M. A.; Delgado, Maria Leonor; Ribeiro, Nilza; Florindo, Cláudia; Tavares, Álvaro A.; Ribeiro, Diana; Lopes, Carlos; et al. "Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implications". Oral Diseases 25 5 (2019): 1291-1301. http://dx.doi.org/10.1111/odi.13089. Published • 10.1111/odi.13089 Alves, Ana; Correia-da-Silva, Marta; Nunes, Claúdia; Campos, João; Sousa, Emília; Silva, Patrícia; Bousbaa, Hassan; et al. "Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations". Molecules 24 3 (2019): 409. http://dx.doi.org/10.3390/molecules24030409. Published • 10.3390/molecules24030409 Henriques, Ana C.; Ribeiro, Diana; Pedrosa, Joel; Sarmento, Bruno; Silva, Patrícia M.A.; Bousbaa, Hassan. "Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution". Cancer Letters 440-441 (2019): 64-81. http://dx.doi.org/10.1016/j.canlet.2018.10.005. Published • 10.1016/j.canlet.2018.10.005 Joana Moreira; Diana Ribeiro; Patrícia Silva; Nair Nazareth; Madalena N Monteiro; Andreia Palmeira; Lucília Saraiva; et al. "New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/129. 10.3390/molecules24010129 Silva, Patrícia. "Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth". Molecules (2018): http://www.mdpi.com/1420-3049/23/5/1093. 10.3390/molecules23051093 Silva, P.M.A.; Ribeiro, N.; Lima, R.T.; Andrade, C.; Diogo, V.; Teixeira, J.; Florindo, C.; et al. "Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel". Cancer Letters 394 (2017): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014640901&partnerID=MN8TOARS. 10.1016/j.canlet.2017.02.024 Diogo, V.; Teixeira, J.; Silva, P.M.A.; Bousbaa, H.. "Spindle Assembly Checkpoint as a Potential Target in Colorectal Cancer: Current Status and Future Perspectives". Clinical Colorectal Cancer 16 1 (2017): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995570267&partnerID=MN8TOARS. 10.1016/j.clcc.2016.06.006 Fonseca, J.; Marques, S.; Silva, P.M.A.; Brandão, P.; Cidade, H.; Pinto, M.M.; Bousbaa, H.. "Prenylated chalcone 2 acts as an antimitotic agent and enhances the chemosensitivity of tumor cells to paclitaxel". Molecules 21 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84980407559&partnerID=MN8TOARS. 10.3390/molecules21080982 Silva, P.M.A.; Tavares, Á.A.; Bousbaa, H.. "Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments". FEBS Letters 589 23 (2015): 3588-3594. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947079444&partnerID=MN8TOARS. 10.1016/j.febslet.2015.10.017 Teixeira, J.H.; Silva, P.M.A.; Faria, J.; Ferreira, I.; Duarte, P.; Delgado, M.L.; Queirós, O.; et al. "Clinicopathologic significance of BubR1 and Mad2 overexpression in oral cancer". Oral Diseases 21 6 (2015): 713-720. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938738610&partnerID=MN8TOARS. 10.1111/odi.12335 Marques, S.; Fonseca, J.; Silva, P.M.A.; Bousbaa, H.; Marques S; Fonseca J; Silva PM; Bousbaa H. "Targeting the spindle assembly checkpoint for breast cancer treatment". Current Cancer Drug Targets 15 4 (2015): 272-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930693970&partnerID=MN8TOARS. 10.2174/1568009615666150302130010 Teixeira, J.H.; Silva, P.M.; Reis, R.M.; Moura, I.M.; Marques, S.; Fonseca, J.; Monteiro, L.S.; Bousbaa, H.. "An overview of the spindle assembly checkpoint status in oral cancer". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903641337&partnerID=MN8TOARS. 10.1155/2014/145289 Silva, P.M.A.; Reis, R.M.; Bolanos-Garcia, V.M.; Florindo, C.; Tavares, Á.A.; Bousbaa, H.. "Dynein-dependent transport of spindle assembly checkpoint proteins off kinetochores toward spindle poles". FEBS Letters 588 17 (2014): 3265-3273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906258277&partnerID=MN8TOARS. 10.1016/j.febslet.2014.07.011 Barbosa, J.; Nascimento, A.V.; Faria, J.; Silva, P.; Bousbaa, H.. "The spindle assembly checkpoint: Perspectives in tumorigenesis and cancer therapy". Frontiers in Biology 6 2 (2011): 147-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051713496&partnerID=MN8TOARS. 10.1007/s11515-011-1122-x Silva, P.; Barbosa, J.; Nascimento, A.V.; Faria, J.; Reis, R.; Bousbaa, H.. "Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint". Cell Proliferation 44 5 (2011): 391-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053152679&partnerID=MN8TOARS. 10.1111/j.1365-2184.2011.00767.x
Journal issue	Silva, Patrícia M. A.; Cristina Pinto Ricardo Xavier. "Recent Trends in Experimental Models for Cancer Research". International Journal of Molecular Sciences (2024): https://www.mdpi.com/journal/ijms/special_issues/NCXFWT0656. Published • Invited editor Odilia Queiros; Silva, Patrícia. "Nano-Drug Delivery Systems for Targeting the Tumor Microenvironment and Simultaneously Overcoming Drug Resistance Properties". Pharmaceutics (2023): https://www.mdpi.com/journal/pharmaceutics/special_issues/BG11RU976G. Published • Invited editor Silva, Patrícia; Cidade, Honorina; Bousbaa, Hassan. "Special Issue "Bioactive Compounds in Cancers". International Journal of Molecular Sciences (2023): https://www.mdpi.com/journal/ijms/special_issues/2I2VLC08N0. Published • Invited editor Silva, Patrícia; Barbosa, Maria Joana; Barbosa, Daniel José; Elaine Fagundes. "Special Issue "The (Un)Desirability of Cell Death in Health and Disease: Emerging Modulators and their Mechanisms"". Frontiers in Cell and Developmental Biology (2023): https://www.frontiersin.org/research-topics/57035/the-undesirability-of-cell-death-in-health-and-disease-emerging-modulators-and-their-mechanisms. Published • Invited editor
Thesis / Dissertation	Silva, Patrícia. "The Spindle Assembly Checkpoint: New Insights Into Its Function, Regulation and Therapeutic Implications". PhD, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2017. http://hdl.handle.net/10400.1/10103. Silva, Patrícia. "Relação entre a proteína Bub3 do checkpoint mitótico e a proteína motora Dineína durante o alinhamento dos cromossomas na placa metafásica". Master, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), 2011. https://repositorio.cespu.pt/handle/20.500.11816/317.
Website	Gonçalves, Virgínia M. F.; Silva, Patrícia M. A.; Azevedo, Rui M.S.. III 1H-TOXRUN International Congress 2024. 2024. https://toxrun.iucs.cespu.pt/congress2024/. Silva, Patrícia M. A.; Gonçalves, Virgínia M. F. ; Azevedo, Rui M.S. II International Congress of UNIPRO Research UNIT (IUCS-CESPU). 2023. https://unipro.iucs.cespu.pt/congress2023/. Silva, Patrícia M. A.; Gonçalves, Virgínia M. F. ; Azevedo, Rui M.S. II TOXRUN International Congress 2023 (IUCS-CESPU). 2023. https://toxrun.iucs.cespu.pt/congress2023/. Bousbaa, Hassan; Gonçalves, Virgínia M. F; Silva, Patrícia M. A.; Barbosa, Maria Joana; Azevedo, Rui M.S. Scientific Journal - Scientific Letters - CESPU. 2022. https://publicacoes.cespu.pt/index.php/sl. Azevedo, R. M.S; Gonçalves, Virgínia M. F. ; Silva, Patrícia M. A.; Monteiro, Luís. UNIPRO - Oral Pathology and Rehabilitation Research Unit - Instituto Universitário de Ciências da Saúde. 2022. https://unipro.iucs.cespu.pt/. Azevedo, Rui M.S; Gonçalves, Virgínia M. F; Silva, Patrícia M. A.; Dinis-Oliveira, Ricardo Jorge. 1H- One Health Toxicology Research Unit (1H-TOXRUN) - Instituto Universitário de Ciências da Saúde. 2021. https://toxrun.iucs.cespu.pt/.

Other

Other output

Antimitóticos de segunda geração (SGAs) em foco: uma segunda oportunidade para aumentar sua eficácia no tratamento do câncer de pulmão.. Research proposal submitted to CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, for funding. Team member.. 2023. Silva, Patrícia.
Contornando a resistência ao Paclitaxel no cancro do ovário. Proposal submitted to "PRÉMIO LIGA INOVAÇÃO 2022", Liga Portuguesa Contra o Cancro. 5000euros. Not funded. Principal Investigator.. 2022. Silva, Patrícia.
2022.06056.PTDC. Chiral Flavonoids: enantioselectivity and (bio)degradability as sustainable strategy to search for new potential anti-inflammatory and antitumor agents. Researcher. Proposal submitted to FCT for funding. Not funded. Team member. 2022. Silva, Patrícia.
2022.02247.PTDC. Os antimitóticos de segunda geração: nova esperança como agentes anticancerígenos?. Researcher. Proposal submitted to FCT for funding. Not funded. Co-Investigator.. 2022. Patrícia M. A. Siva.
2022.01567.PTDC. Creation of a drug test using ovarian cancer ascites-derived organoids. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2022. Silva, Patrícia M. A..
2022.05468.PTDC. Unravelling new analgesic drugs: the therapeutic potential of krokodil morphinans. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2022. Patrícia MA..
PTDC/MED-ONC/3136/2021. The second-generation of antimitotics: a second chance?. Co-Principal Researcher. Proposal submitted to FCT for funding. Not funded. Co-Investigator. 2021. Silva, Patrícia M. A..
PTDC/BIA-CEL/4442/2021. Control of Cell Proliferation.. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2021. Silva, Patrícia M. A..
PTDC/QUI-QOR/2896/2021. Xanthones and flavonoids: chirality and (bio)degradability as sustainable strategy to search for new potential anti-inflammatory and antitumor agents.. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2021. Silva, Patrícia M. A..
PTDC/QUI-QOR/2731/2021. 2D-Lipid tags as biomolecular tools for breast cancer detection. Researcher. Proposal submitted to FCT for funding. Not funded. 2021.
PTDC/MED-ONC/1360/2020. Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents.. Researcher. Proposal submitted to FCT for funding. Not funded. 2020.
PTDC/CTA-OHR/3912/2020. Natural products as antitumor agents: bioprospecting, synthesis and nanotechnological approaches to improve antitumor activity.. Researcher. Proposal submitted to FCT for funding. Not funded. 2020.
PTDC /QUI-QOR/5732/2020. Chiral derivatives of xanthones and flavonoids: an integrative strategy to discovery new drug candidates.. Researcher. Proposal submitted to FCT for funding. Not funded. 2020.
C492597698-00087532. Therapeutic targeting of cell division through nanoparticle-mediated siRNA delivery for the treatment of oral cancer.. Researcher. Proposal submitted to FCT for funding. Not funded. 2017.
PTDC/BIM-ONC/0195/2014. NanoAntiMito: Therapeutic targeting of cell division through functionalized nanoparticle-mediated siRNA delivery for the treatment of lung cancer. Researcher. Proposal submitted to FCT for funding. Not funded. 2014.
PTDC/BEX-BCM/0322/2012. Functional Relationship Between the Human Motor Protein Dynein and the Spindle Assembly Checkpoint Proteins in Chromosome Alignment During Mitosis. Researcher. Proposal submitted to FCT for funding. Not funded. 2012.
PTDC/BIA-BCM/122717/2010. Functional Relationship Between the Human Motor Protein Dynein and the Spindle Assembly Checkpoint Proteins in Chromosome Alignment During Mitosis. Proposal submitted to FCT for funding. Not funded. 2010.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/05/02	Evaluation of antitumor activity of xanthones conjugated with amino acids. https://doi.org/10.48797/sl.2024.261	III 1H-TOXRUN International Congress 2024 (Porto, Portugal)
2023/11/30	The Role of the Pharmacist in Oncological Research (Invited speaker)	XIV Workshop de Prática de Farmácia. IUCS-CESPU (Portugal)
2023/06/02	Promoting oral cancer cell death by combining an apoptosis inducer with an antimitotic	II International Congress of UNIPRO Oral Pathology and Rehabilitation Research Unit (Penafiel, Portugal)
2022/04/08	Targeting BUB3 in combination with paclitaxel inhibits proliferation of glioblastoma cells by enhancing cellular senescence	Congress 2022 APCF-TOXRUN TOXRUN (Porto)
2021/11/27	Explorando a atividade antitumoral do composto BP-M345.	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS) RACS (Benguela, Angola)
2021/11/26	Análise do potencial antitumoral da combinação de um inibidor de MPS-1 e um indutor de apoptose em culturas 2D e 3D de cancro do pulmão	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS) RACS (Benguela, Angola)
2021/11/26	Expressão e potencial terapêutico da proteína MPS-1 no cancro oral	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS) RACS (Benguela, Angola)
2021/11/26	Inibição da Bub3: uma estratégia promissora na potenciação do efeito antitumoral do paclitaxel	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS) RACS (Benguela, Angola)
2021/11/25	Interferindo com a proteína p31comet aumenta a citotoxicidade do Paclitaxel e do Navitoclax em esferóides do cancro do pulmão	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS) RACS (Benguela, Angola)
2020	Potenciação da morte celular induzida pelo Navitoclax em combinação com antimitóticos	3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS (Braga, Portugal)
2020	A inibição da proteína p31comet sensibiliza as células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel	3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS (Braga, Portugal)
2020	Investigando a atividade antitumoral do composto XJS2 e seu mecanismo de ação	3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS (Braga, Portugal)
2020	Avaliação da atividade antitumoral de derivados xantónicos	3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS (Braga, Portugal)
2019/11/20	New chalcone derivatives with antimitotic activity: synthesis, antitumor activity evaluation and chemosensitivity studies.	XXV Encontro Galego-Portugues de Química COLQUIGA & SPQ (Santiago de Compostela, Spain)
2019/05/17	Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations	4th Meeting on Medicinal Biotechnology Escola Superior de Saúde do Porto (Porto, Portugal)
2018/09/07	Antitumor Chalcone Derivatives: Synthesis and Biological Activity Evaluation.	IJUP 2018, 11º Encontro de Investigação Jovem da Universidade do Porto University of Porto (Porto, Portugal)
2018/03/07	Chalcone Derivatives with Potential Antitumor Activity: Synthesis and Antimitotic Activity Evaluation.	National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting Faculty of Pharmacy of the University of Porto (Porto, Portugal)
2017/09/14	2’,4’-Dihydroxy-3,4,5-Trimethoxychalcone Analogues: Synthesis, Biological Activity and Docking Studies.	12th YES (Young European Scientist) Meeting Faculty of Medicine of the University of Porto (Porto, Portugal)
2017/02/08	Heterocyclic Chalcone Derivatives: Synthesis, Antitumor Activity and Docking studies.	IJUP 2017, 10º Encontro de Investigação Jovem da Universidade do Porto University of Porto (Porto, Portugal)
2016/12/15	Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis	Jornadas dos Doutorandos em Ciências Biomédicas Universidade do Algarve (Faro, Portugal)
2016/10/28	A mitose como alvo terapêutico contra o cancro	I Congresso Nacional de Ciências Biomédicas Laboratoriais Instituto Politécnico de Bragança (Bragança, Portugal)
2015/12/14	Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis	Jornadas dos Doutorandos em Ciências Biomédicas Universidade do Algarve (Faro, Portugal)
2015/05/13	Evaluation of the antimitotic activity of a new prenylated chalcone in NCI-H460 non-small cell lung cancer cells	IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto University of Porto (Porto, Portugal)
2015/05/13	Therapeutic targeting of the mitotic checkpoint to increase sensitivity of glioblastoma cells to anti-mitotic agents	IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto University of Porto (Porto, Portugal)
2015/05/13	Targeting Cdc20 protein to increase sensitivity of colorectal cancer cells to paclitaxel	IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto University of Porto (Porto, Portugal)
2015/05/13	A new prenylated chalcone induces mitotic arrest and cell death by mitotic catastrophe in MCF-7 breast cancer cell line	IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto University of Porto (Porto, Portugal)
2014/12/15	Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis	Jornadas dos Doutorandos em Ciências Biomédicas Universidade do Algarve (Faro, Portugal)
2014/11/06	Tracking dynein-mediated transport of spindle assembly checkpoint proteins from kinetochore to spindle pole	INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society Faculty of Engineering of the University of Porto (Porto, Portugal)
2013/12/17	Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis	Jornadas dos Doutorandos em Ciências Biomédicas Universidade do Algarve (Faro, Portugal)
2012/03/07	Relationship between mitotic checkpoint proteins and aneuploidy	II Pathological Anatomy Symposium IPSN-CESPU (Gandra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/09 - Current	Targeting Eg5 and BCL-2 to overcome paclitaxel resistance in ovarian cancer. Co-supervisor of Carina Isabel Ribeiro Gomes	Biomedical Sciences (Degree) Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2023/09 - Current	Targeting Mps1 and BCL-XL/BCL-2 to overcome paclitaxel resistance in ovarian cancer. Co-supervisor of Francisca Nazaré de Mesquita Sampaio	Biomedical Sciences (Degree) Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2023/09 - Current	Mitotic proteins KSP and Aurora B: potential biomarkers and treatment targets for oral cancer Co-supervisor of Raquel Maria Sousa Silva	Biomedical Sciences (Degree) Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2023 - Current	Curcumine and oral cancer (Preliminary) Co-supervisor of Mathilde Rouffineau	Medicina Dentária (Integrated Master) (Master) Instituto Universitário de Ciências da Saúde, Portugal
2021/02/01 - Current	The Second-generation of antimitotics: mechanistic insights into the anticancer activity and therapeutic potential Co-supervisor of João Pedro Nunes Silva	Ciências Biomédicas (PhD) Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2020/02 - Current	3D tumor spheroids as preclinical models to study oral Cancer Co-supervisor of Mafalda Maria Calheiros Lobo Duarte Pinto Guimarães	Ciências Biomédicas (PhD) Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2022/10 - 2023/07/11	Characterization of the cytotoxicity mechanism of new molecules with antitumor potential Co-supervisor of Eliseba Lima Martins Castro	Ciências Biomédicas (Degree) Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2021/09 - 2022/07	Improving the antitumoral activity of second-geneation antimitotics Co-supervisor	Ciências Biomédicas (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - 2022/07	Improving the antitumoral activity pf second-geneation antimitotics. Co-supervisor	Ciências Biomédicas (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020/12/18	Investigating the antitumoral activity and mechanism action of the a xanthone derivative Co-supervisor of Fábio França Vieira e Silva	Oncobiologia - Mecanismos Moleculares do Cancro (Master) Universidade do Algarve, Portugal
2019 - 2020	Evaluation of antitumor activity of a small molecule Co-supervisor	Ciências Biomédicas (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020	Evaluation of antitumor activity of a small molecule Co-supervisor	Ciências Biomédicas (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2018 - 2018	Avaliação da atividade antitumoral de pequenas moléculas naturais e sintéticas Co-supervisor	Ciências Biomédicas (Scientific initiation) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2018 - 2018	Avaliação da atividade antitumoral de pequenas moléculas de origem natural e sintética Co-supervisor	Ciências Biomédicas (Degree) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017 - 2017	Antitumor Chalcone Derivatives: synthesis and biological activity evaluation Co-supervisor	Química Farmacêutica (Master) Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2017	Evaluation of the antitumoral activity of small molecules with natural and synthetic origin Co-supervisor	Bioquímica (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2016 - 2017	Avaliação da atividade antiproliferativa de uma pequena molécula em linhas celulares do cancro da mama Co-supervisor	Bioquímica (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015	Screening for small molecules with potential antitumour activity and characterization of the antimitotic activity of a prenylated chalcone in NCI-H460 non- small cell lung cancer cells Co-supervisor	Terapias Moleculares (Master) Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015	Screening and identification of small molecules with potential antitumour activity and insight into the mechanism of action of a prenylated chalcone in MCF-7 breast cancer cells Co-supervisor	Terapias Moleculares (Master) Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015	Evaluation of the antiproliferative activity of a small molecule in human cancer cell lines Co-supervisor	Biologia Aplicada (Degree) Universidade do Minho, Portugal
2015 - 2015	Avaliação da atividade antiproliferativa de uma pequena molécula em linhas celulares do cancro da mama Co-supervisor	Medicina (Other) Universidade do Algarve, Portugal
2014 - 2015	Checkpoint mitótico como alvo terapêutico para sensibilizar células cancerígenas a agentes antimitóticos Co-supervisor	Oncobiologia - Mecanismos Moleculares do Cancro (Master) Universidade do Algarve, Portugal
2014 - 2015	Interferindo com o "checkpoint" mitótico para potenciar a ação de agentes anti-mitóticos Co-supervisor	Oncobiologia - Mecanismos Moleculares do Cancro (Master) Universidade do Algarve, Portugal
2014 - 2014	Silenciamento do Checkpoint Mitótico: Transporte da proteína Mad2 dos cinetocoros para os pólos do fuso mitótico, via Dineína Citoplasmática em Células HeLa Co-supervisor	Medicina (Other) Universidade do Algarve, Portugal
2013 - 2013	Depleção da proteína Mad2 por RNAi em células HeLa Co-supervisor	Medicina (Other) Universidade do Algarve, Portugal
2013 - 2013	Depleção da proteína Mad2 por RNAi em células HeLa Co-supervisor	Medicina (Other) Universidade do Algarve, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2024/10/19 - 2024/10/19	Lançamento do Livro Infantil "Mas...o que é o Cancro?", no Centro de Estudos Camiliano, Vila Nova de Famalicão. (2024/10/19 - 2024/10/19) Other (Other)
2024/05/02 - 2024/05/03	III 1H-TOXRUN International Congress 2024 \| Porto - Portugal (2024 - 2024) Congress (Other)	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2023/06/01 - 2023/06/02	II International Congress of UNIPRO Research Unit 2023 \| Penafiel, Portugal (2023/06/01 - 2023/06/02) Congress (Member of the Organising Committee)	Instituto Universitário de Ciências da Saúde, Portugal
2023/04/27 - 2023/04/28	II TOXRUN International Congress 2023 \| Porto - Portugal (2023 - 2023) Congress (Other)	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2022/04/07 - 2022/04/08	I Congresso Internacional da TOXRUN, O V Congresso Internacional da APCF¿ e as XIV Jornadas Científicas do IUCS-CESPU (2022/04/07 - 2022/04/08) Congress (Member of the Organising Committee)	Associação Portuguesa de Ciências Forenses, Portugal Instituto Universitário de Ciências da Saúde, Portugal
2022/04/07 - 2022/04/08	1st International Congress of UNIPRO Research Unit (IUCS - CESPU), includinh the Conference on Advances in Research on Oral Cancer convened by UNIPRO and the WHO Collaborating Centre on Oral Cancer (2022/04/07 - 2022/04/08) Congress (Member of the Organising Committee)	Instituto Universitário de Ciências da Saúde, Portugal
2017 - 2019	Workshop do IINFACTS (Annual) (2016 - 2019) Workshop (Co-organisor)	Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023/05/08 - Current	2º EnantioTox Workshop Series - Análise de dados em biociências com ferramentas open source: uma abordagem prática. Workshop	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2024/03/07 - 2024/03/07	II Jornadas de Ética da CESPU. “A Ética na Investigação e na vida Universitária” Conference	II Jornadas de Ética da CESPU. “A Ética na Investigação e na vida Universitária” Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2021/06/16 - 2023/06/16	Conversations in BioMed. FMCB PhD Alumni Meeting. Meeting	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/10/27 - 2022/10/27	PhD Day 2022 Meeting	PhD Day 2022 Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2022/09/24 - 2022/09/24	4º Encontro Nacional de Jovens Investigadores em Oncologia (4º ENJIO) Meeting	4º Encontro Nacional de Jovens Investigadores em Oncologia (4º ENJIO) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2022/09/24 - 2022/09/24	Participação e apresentação de trabalho Meeting	4º Encontro Nacional de Jovens Investigadores em Oncologia (4º ENJIO) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2022/07/26 - 2022/07/26	1º EnantioTox Workshop Series - “Elaboração de desenhos, esquemas, mapas, resumos gráficos, literacia e comunicação visual, com recurso ao PowerPoint”. Componentes teórica (1h30)e prática (3h00) Workshop	1º EnantioTox Workshop Series - “Elaboração de desenhos, esquemas, mapas, resumos gráficos, literacia e comunicação visual, com recurso ao PowerPoint” Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/04/07 - 2022/04/08	I Congresso Internacional da TOXRUN, O V Congresso Internacional da APCF¿ e as XIV Jornadas Científicas do IUCS-CESPU Congress
2022/03/01 - 2022/03/01	LSM Plus & Airyscan Joint Deconvolution User Workshop (online) Workshop	Carl Zeiss AG, Germany
2021/11/25 - 2021/11/27	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia ¿ 4ª rRACS, Benguela-Angola (online) Congress	4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 4ª rRACS, Benguela-Angola
2020/10/27 - 2020/10/28	3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia 3ª rRACS (online) Congress	3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
2016/10 - 2016/10	I Congresso Nacional de Ciências Biomédicas Laboratoriais Congress	I Congresso Nacional de Ciências Biomédicas Laboratoriais Instituto Politécnico de Bragança, Portugal
2016/04/28 - 2016/04/29	2nd International Congress Aspic Congress	2nd International Congress Aspic Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2014/11/06 - 2014/11/07	INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society. Conference	INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society.
2014 - 2014	EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function Conference	EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function European Molecular Biology Laboratory, Germany
2013 - 2013	XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting Meeting	XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013 - 2013	Embo Young Scientists´Forum Symposium	Embo Young Scientists´Forum
2010/10/29 - 2010/10/29	Meeting Gynecological Cytology: Basic and Advanced Principles Symposium	Meeting Gynecological Cytology: Basic and Advanced Principles Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010/09/08 - 2010/09/09	III CICS – UnIPSa – CITS Workshop Workshop	III CICS – UnIPSa – CITS Workshop Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2010/07/23 - 2010/07/23	“LC-MS/MS Mini-Symposium: from small molecules to macromolecules” Symposium	“LC-MS/MS Mini-Symposium: from small molecules to macromolecules” Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2009/10/09 - 2009/10/10	II CICS – UnIPSa – CITS Workshop Workshop	II CICS – UnIPSa – CITS Workshop Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2008/07/24 - 2008/07/24	I CICS – UnIPSa – CITS Workshop: “Research lines” Workshop	I CICS – UnIPSa – CITS Workshop: “Research lines” Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2008/05/16 - 2008/05/18	X Technical Congress in Pathological Anatomy, Costa da Caparica Congress	X Technical Congress in Pathological Anatomy, Costa da Caparica
2008/04/15 - 2008/04/16	I Congress of IPSN Congress	I Congress of IPSN Instituto Politécnico de Saúde do Norte, Portugal
2008/01/26 - 2008/01/27	V Inter-Service Meeting for Pathological Anatomists in the Area of Cytology Meeting	V Inter-Service Meeting for Pathological Anatomists in the Area of Cytology Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2007/06/02 - 2007/06/03	IX Technical Congress in Pathological Anatomy Congress	IX Technical Congress in Pathological Anatomy Fundação Dr. António Cupertino de Miranda, Portugal
2006/11/28 - 2006/11/29	II APEF Scientific Congress – “Stem Cells and Nanotechnology” Congress	II APEF Scientific Congress – “Stem Cells and Nanotechnology” Universidade Portucalense Infante Dom Henrique, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/07/16	Studies on the Expression of Neurotoxicity Biomarkers Resulting from Exposure to Therapeutic Doses of Tramadol and Tapentadol in Prefrontal Cortex Samples. (Thesis) Main arguer	Lília da Rocha Rodrigues (Other) Instituto Universitário de Ciências da Saúde, Portugal
2024/07/11	Recent advances in microtubule targeting agents for cancer therapy. (Thesis) Main arguer	Henrique Carvalho Assunção (Master) Universidade do Porto Faculdade de Farmácia, Portugal
2023/07/19	Tramadol and Tapentadol: Nephro- and neurotoxicity biomarkers expression after exposing rats to therapeutic doses (Thesis) Main arguer	Ana Rita Dantas de Barros (Other) Instituto Universitário de Ciências da Saúde, Portugal
2023/07/11	Evaluation of Chemoresistance Biomarkers in Ovarian Cancer Cell Lines (Thesis) Main arguer	Anabela Bianca Moreira Costa (Other) Instituto Universitário de Ciências da Saúde, Portugal
2021/12/17	Caracterização da proteína Mob4 humana. Um estudo da execução da mitose. (Thesis) Main arguer	Andreia Isabel Alves Colaço (Master) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2021/07/08	Study of the mechanisms of genotoxicity from subacute exposure to tapentadol (Thesis) Main arguer	Ana Rita Leite da Silva (Other) Instituto Universitário de Ciências da Saúde, Portugal
2021/07/08	P-glycoprotein expression analysis in ovarian tumours recurrences. (Thesis) Main arguer	Henrique da Silva Ferreira (Other) Instituto Universitário de Ciências da Saúde, Portugal

Committee member

	Activity description Role	Institution / Organization
2024/10/16 - 2024/10/16	Member of the Scientific Committee of the PhD Day 2024, IUCS-CESPU Member	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Patologia e Reabilitação Oral, UNIPRO (IUCS-CESPU)), Portugal
2023/10/27 - 2023/10/27	Member of the Scientific Committee of the PhD Day 2023 IUCS-CESPU Member	Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2022/10/27 - 2022/10/27	Member of the Scientific Committee of the PhD Day 2022, IUCS-CESPU Member	Instituto Universitário de Ciências da Saúde, Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024/09 - Current	Cell Biology	Fisiologia Clínica (Licenciatura)	Instituto Politécnico de Saúde do Norte - Campus de Famalicão, Portugal
2021/09 - Current	Morfologia e Funções do Corpo Humano I	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - Current	Morfologia e Funções do Corpo Humano III	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - Current	Morfologia e Funções do Corpo Humano IV	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - Current	Morfologia e Funções do Corpo Humano V	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2020 - Current	Advanced Course in Oncobiology (Teaching)	Ciências Biomédicas (Doutoramento)	Instituto Universitário de Ciências da Saúde, Portugal
2012 - 2021	Cellular and Molecular Biology	Basic Health Sciences (Pós-Graduação)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2012 - 2021	Cellular and Molecular Biology	Dental Medicine (Mestrado integrado)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2017 - 2018	General histology and embryology	Dental Medicine (Mestrado integrado)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2015 - 2018	Advanced Course in Oncobiology (Teaching)	PhD Program in Biological Sciences Applied to Health (Doutoramento)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2012 - 2018	Cell Biology	Pharmaceutical Sciences (Mestrado integrado)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2011 - 2013	Cell Biology	Nutrition Sciences (Licenciatura)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2011 - 2012	General Molecular and Cellular Biology	Forensic Sciences	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2011 - 2012	Human Biology I	Clinical Psychology (Licenciatura)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2010 - 2012	Advanced course in Molecular Pathology (Teaching \| Cytopathology Concepts)	Molecular Therapy (Mestrado)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2008 - 2011	Biosecurity	Pathological, Cytological and Thanatological Anatomy (Licenciatura)	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023/12 - 2024/01	Reviewer of a Research Project application for funding by CESPU, under the call GI2-CESPU-2023. Gabinete para a Investigação e a Inovação (GI2) - CESPU Grants.	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
2022 - 2022	Reviewer of a Research Project application for funding by CESPU, under the call GI2-CESPU-2022. Gabinete para a Investigação e a Inovação (GI2) - CESPU Grants.	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal	Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2017	Inibição de proteína associada à divisão celular ajuda no tratamento do cancro - estudo	Diário de Notícias
2017	Investigadores do Porto descobrem como levar as células cancerígenas ao "suicídio"	SIC Notícias
2017	Eliminação da Spindly: um gatilho para o suicídio de células cancerígenas	ASPIC

Journal scientific committee

	Journal title (ISSN)	Publisher
2024 - Current	Molecules	MDPI
2024 - Current	International Journal of Molecular Sciences	MDPI
2024 - Current	Frontiers in Oncology	Frontiers
2022/06 - Current	BMC Cancer	Springer Nature
2022/02/24 - Current	Cancer Cell International	Springer Nature
2022 - Current	Frontiers in Pharmacology	Frontiers
2013 - Current	Cell Proliferation (1365-2184)	Wiley (Blackwell Publishing)

Distinctions

Award

2023	Annual Scientific Productivity Award 2023 Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal Instituto Universitário de Ciências da Saúde, Portugal
2022	Excellence Award from the Portuguese Association of Forensic Sciences - Professor Doctor Duarte Nuno Vieira. II TOXRUN International Congress Associação Portuguesa de Ciências Forenses, Portugal MDPI AG, Switzerland
2013	Travel grants EMBO Young Scientists’ Forum Instituto de Medicina Molecular João Lobo Antunes, Portugal
2013	PhD fellowship (SFRH/BD/90744/2012) Fundação para a Ciência e Tecnologia (FCT), Portugal