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Sandra started her career with a BSc in Chemistry (2008, Univ. of Coimbra, PT) with specialization in chemistry of biological processes, during which she was granted an Erasmus Mundus fellowship, to do part of her studies at the Univ. of Santiago de Compostela, Spain. Here she worked on the synthesis of chelating agents for heavy metal poisoning therapies. She studied a MSc in Organic Chemistry (2010) at the same university, where she started working on the field of organic synthesis applied to the dendritic polymers under the supervision of Dr. E. Fernandez Megía and Prof. R. Riguera. During this time she developed an optimised and scaled-up synthesis of the repeating unit of GATG dendrimers based on green chemistry and atom economy principles. Along with this project she also worked on the preparation of two different families of high generation GATG dendrimers, which have shown excellent results in several biomedical applications. During this time she published an article (Org. Lett. 2011; Q1; IF 6.49), a patent [P201030966 (ES)], 2 oral and 2 poster communications. Afterwards she started the PhD within the same research group (2011, CIQUS/USC) where she got involved in more multidisciplinary projects also including the synthesis of dendrimers but also PEGylated linear and dendritic block-copolymers, including an accelerated synthesis of biodegradable structures prepared using microwave synthesis, click chemistry, and green chemistry principals (article in preparation). The synthesised polymers were used to prepare drug delivery systems (DDS) at the nanoscale such as polymeric micelles and polymersomes with sensitivity to external stimuli such as pH, ionic strength or concentration of bioactive compounds with particular chemical structures. Moreover, she has also worked on the encapsulation of different commercial pharmaceutical drugs such as anticancer agents. She has performed in vitro DD studies and cell experiments to study the internalisation ability of these DDS using fluorescence and confocal microscopy as well as cytotoxicity assays. In collaboration with the Dr. J. Costas and Dr. A. Vidal (CIMUS, USC) they have demonstrated the importance of the size of the DDS in their in vivo biodistribution. This work granted the publication of one very good article (Angew. Chem. Int. Ed. Engl. 2018; Q1; IF 12.1), 2 oral and 2 poster communications, and another article in preparation. Furthermore, in an international collaboration with the Prof. Cameron Alexander (Univ. of Nottingham, UK), they have shown the ability of the polymers developed by her to mediate clustering of bacteria and act as microbicides (Biomaterials Science 2016; Q1; IF 5.8). Before defending the PhD (2017), she moved to the UK where she was part of the science start-up incubator Deep Science Ventures (DSV), which explores science-related ideas from a commercial perspective. Her tasks within the company were to work along other scientists, engineers and business consultants to explore science-related ideas from a commercial perspective, covering areas such as health, sustainability and development of cutting-edge biomaterials. One of the main projects she was involved, focused on the redesign and functionalization of current cellulosic textile fibres for maximization of functions such as fire resistance and recyclability enhancement. After finishing the PhD she decided to take a sabbatical year to work on a non-science related area, and finally, in June 2019 she returned to her home country to start a Postdoc position at ICVS/3B’s research group (Univ. do Minho, PT), which focus on biopolymers, biomimetics and biodegradables for tissue engineering and regenerative medicine applications. Here she currently works along with Dr. Ramón and Dr. Iva Pashkuleva on the synthesis of proteoglycan mimetics for the development of brush-like glycosaminoglycan (GAG) copolymer hydrogels, for the reconstruction of cartilage nanostructures.
Identification

Personal identification

Full name
SANDRA CRISTINA PEREIRA AMARAL

Citation names

  • Amaral, Sandra
  • Amaral, Sandra P.

Author identifiers

Ciência ID
4D12-00FC-ED63

Email addresses

  • sandra.amaral@i3bs.uminho.pt (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Polymer Science
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Engineering and Technology - Nano-technology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/06/17 - 2021/12/17
Ongoing
Postdoctoral Researcher (Pós-doutoramento)
Major in Tissue Engineering and Regenerative Medicine
Laboratório Associado ICVS 3B's, Portugal
2017/12/01
Concluded
Doctorado en Ciencia y Tecnología Química (Doctor)
Universidade de Santiago de Compostela, Spain
"Dendrimers: Accelerated Synthesis, Control of Size and Biodistribution of Micelles" (THESIS/DISSERTATION)
Cum Laude
2010
Concluded
Master en Química Orgánica (Master)
Major in Química de Polímeros
Universidade de Santiago de Compostela, Spain
"Click Chemistry y Polímeros Dendríticos. Preparación de Nanoestructuras Poliméricas." (THESIS/DISSERTATION)
8/10
2008
Concluded
Química (Licenciatura)
Major in Química de Processos Biológicos
Universidade de Coimbra, Portugal
14
Affiliation

Science

Category
Host institution
Employer
2019/06/17 - Current Contracted Researcher (Research) Universidade do Minho, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
2017/07 - 2017/11 Postdoc (Research) Deep Science Ventures, United Kingdom
Projects

Contract

Designation Funders
2019/06/17 - Current Reconstruction of Cartilage Nanostructures by Brush Like Copolymers that Mimic Proteoglycans
C491773512-00084360
Researcher
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2016/01/01 - 2017/12/01 Centros de Investigacioín Singulares 2016
ED431G/09
Researcher
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Spain
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
Ongoing
2014/06/24 - 2017/11/30 Nanomaterials and Bioactive Molecules
GRC2014/040
Researcher
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Spain
Xunta de Galicia Consellería de Sanidade
Concluded
2013/01/01 - 2015/12/31 PIC (polyion complex) micelles with stability in physiologic conditions as nanosystems for diagnostics and the transport of therapeutic proteins
CTQ2012-34790
Researcher
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Spain
Gobierno de España Ministerio de Economía y Empresa
Concluded
2010/08/08 - 2013/09/30 Accelerated processes for the preparation and multifunctionalization of nanodevices for diagnostics and transport of proteins and SI-RNA
10CSA209021PR
Researcher
Universidad de Santiago de Compostela Departamento de Química Orgánica, Spain
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
Concluded
Outputs

Publications

Conference poster
  1. Novoa-Carballal, Ramón; Amaral, Sandra P.; Valcarcel, Jesus; Gomes, Marisa; Vazquez, Jose Antonio; Carretero, Agatha; Reis, Rui L.; Pashkuleva, Iva. "Multivalent presentation of glycosaminoglycans by their end-on conjugation to star and linear polymers". Paper presented in 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  2. Novoa-Carballal, Ramón; Amaral, Sandra P.; Gomes, Marisa; Valcarcel, Jesus; Vazquez, Jose Antonio; Carretero, Agatha; Reis, Rui L.; Pashkuleva, Iva. "Multivalent Proteoglycan Mimics Generated from Glycosaminoglycans end-on Linked to Star and Linear Polymers". Paper presented in Term Stem 2019, 2019.
  3. Amaral, Sandra P.; Leire, Emma; Fernandez-Trillo, Francisco; Correa, Juan; Fernandez-Megia, Eduardo. "Multifunctional dendrimers as modular platforms for the development of new generation microbicides". Paper presented in IV 2015 UKICRS Workshop & Symposium, 2015.
  4. Amaral, Sandra P.; Fernandez-Megia, Eduardo; Riguera, Ricardo. "Design, synthesis and characterization of new GATG dendritic architectures". Paper presented in Biodendrimer, 2012.
  5. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Muñoz, Eva; Correa, Juan; Fernandez-Trillo, Francisco; Sousa-Herves, Ana; Novoa-Carballal, Ramón; Riguera, Ricardo; Fernandez-Megia, Eduardo. "GATG Dendrimers: Multivalent nanostructures for biomedical applications". Paper presented in 2nd International Symposium of the Collaborative Research Center (SFB), 2012.
  6. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Correa, Juan; Fernandez-Megia, Eduardo; Riguera, Ricardo. "An optimizad protocol for the multigram síntesis of the repeating unit of GATG dendrimers". Paper presented in 2nd International Symposium of Biological Applications of Dendrimers (Bio-Dendrimers), 2010.
  7. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Correa, Juan; Fernandez-Megia, Eduardo; Riguera, Ricardo. "Improved and scaled-up síntesis of the repetition unit of GATG dendrimers". Paper presented in 2do Simposio Iberoamericano de Química Orgánica, 2010.
Journal article
  1. Amaral, Sandra P.; Muna A. Al-Ni'mat; Samuel Parcero-Bouzas; Eduardo Fernandez Megía. "Self-assembly Dendritic Boronate Micelles as a Promising Delivery Strategy for Gemcitabine". ChemRxiv preprint (2020):
    Open access
  2. Amaral, Sandra P.; Tawara, Maun H.; Fernandez-Villamarin, Marcos; Borrajo, Erea; Martínez-Costas, José; Vidal, Anxo; Riguera, Ricardo; Fernandez-Megia, Eduardo. "Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes". Angewandte Chemie International Edition 57 19 (2018): 5273-5277. http://dx.doi.org/10.1002/anie.201712244.
    Published • 10.1002/anie.201712244
  3. Leire, Emma; Amaral, Sandra P.; Louzao, Iria; Winzer, Klaus; Alexander, Cameron; Fernandez-Megia, Eduardo; Fernandez-Trillo, Francisco. "Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability". Biomaterials Science 4 6 (2016): 998-1006. http://dx.doi.org/10.1039/c6bm00079g.
    10.1039/c6bm00079g
  4. Amaral, Sandra P.; Fernandez-Villamarin, Marcos; Correa, Juan; Riguera, Ricardo; Fernandez-Megia, Eduardo. "Efficient Multigram Synthesis of the Repeating Unit of Gallic Acid-Triethylene Glycol Dendrimers". Organic Letters 13 17 (2011): 4522-4525. http://dx.doi.org/10.1021/ol201677k.
    Published • 10.1021/ol201677k
Thesis / Dissertation
  1. Amaral, Sandra P.. "Dendrimers: Accelerated Synthesis, Control of Size and Biodistribution of Micelles". PhD, Centro Singular de Investigación en Química Biológica y Materiales Moleculares, 2017.
  2. Amaral, Sandra P.. "Click Chemistry and Dendritic Polymers. Preparation of Polymeric Nanostructures.". Master, Universidad de Santiago de Compostela Departamento de Química Orgánica, 2010.

Intellectual property

Patent
  1. Amaral, Sandra; Fernandez-Villamarin, Marcos; Correa, Juan; Riguera, Ricardo; Fernandez-Megia, Eduardo. 2011. "Procedimiento mejorado para la obtención de dendrímeros". Spain.
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2014 Multivalent scale of the repeating unit and synthesis of new dendritic architectures IV Encuentro sobre Dendrímeros EDEN4
Universidad de Santiago de Compostela (Santiago de Compostela, Spain)
2012 GATG Dendrimers: Multivalent nanostructures for biomedical applications 2nd International Synposium of the Collaborative Research Center (SFB)
SFB (Berlim, Germany)
2011 Efficient multigram synthesis of the repeating unit of gallic acid-triethylene glycol dendrimers Dendrimers as composites of advanced drug delivery nano systems (aDDnSs). Biomedical applications.
(Atenas, Greece)
2010 Dendrímeros GATG: síntese da unidade de repetiçao a grande escala e de novas familias dendríticas XVI Encontro Luso-Galego de Química
Universidade de Aveiro (Aveiro, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2014 - 2014 Membro da comissao organizadora do congresso EDEN4 (2014)
Congress (Member of the Organising Committee)
Universidade de Santiago de Compostela, Spain

Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Spain

Event participation

Activity description
Type of event
Event name
Institution / Organization
2011/10/04 - 2011/10/09 Participation on the Training School and Workshop "Dendrimers as Composites of Advanced Drug Delivery nano Systems (aDDnDs). Biomedical Applications." organised by within the COST scientific programme on Dendrimers in Biomedical Applications at University of Athens
Workshop
Training School and Workshop
Ethniko kai Kapodistriako Panepistemio Athenon, Greece

Mentoring / Tutoring

Topic Student name
2012/10/01 - 2015/10/01 PhD thesis on Multifunctional Dendrimers for Antibacterial Applications Emma Leire
2013/10/01 - 2015/09/30 BSc and MSc thesis "Dendritic Micelles as Drug Delivery Systems for the Transport of Anticancer Drugs" Lucía Álvarez Álvarez
Distinctions

Title

2017 "Cum Laude" PhD Dissertation
Universidade de Santiago de Compostela, Spain

Other distinction

2011 Training School Grant
Ethniko kai Kapodistriako Panepistemio Athenon, Greece