Nuno Miguel Formiga Borges (4D1C-299C-14B6)

Curriculum Vitae

Nuno Miguel Formiga Borges

Nuno Borges is Auxiliary Researcher at the Marine and Environmental Sciences Centre - Polytechnic Institute of Setúbal (MARE-IPS). He is Invited Adjunct Professor of Microbiology (Environmental and Food) and Food Safety in Aquaculture at the Setúbal School of Technology, Polytechnic Institute of Setúbal (EST-IPS), Portugal. He graduated in biochemistry at the Faculty of Sciences, University of Lisbon (Portugal) in 1999. He obtained his Ph.D. degree in biochemistry at the Instituto de Tecnologia Química e Biológica (ITQB), New University of Lisbon (Portugal) in 2004, and was a postdoctoral fellow at the ITQB (Portugal), Universidad Autónoma de Madrid (Spain), and Kyoto University (Japan) from 2004 to 2008. He was then awarded the Research Scientist contract "Ciência" (2008-2019) at the ITQB. From 2019 to 2021, he was a doctorate Researcher at the Institute for Bioengineering and Biosciences, Instituto Superior Técnico (Portugal). He has published 34 articles in peer-reviewed international journals, with an h-index of 21 and an i-10 index of 27. His published work has been cited more than 1,400 times, being welcomed by highly ranked, multidisciplinary, and specialized journals such as Annual Reviews in Animal Biosciences, Environmental Microbiology, Nature communications, Microbiological Research, and applied and Environmental Microbiology. Since 2007, he has contributed as reviewer for several indexed journals, including Extremophiles, J. Bacteriology, and Research in Microbiology. Since 2010, he has supervised 4 Ph.D., 2 M.Sc., and 4 undergraduate students (1 ongoing) in the framework of 16 R&D projects (2 as principal investigator). He was invited to deliver 5 oral communications in international conferences. He co-organized one international congress (400 participants) and was engaged as a co-organizer or participant in several dissemination activities. Dr. Borges's interest in the development of microbiome-derived applications to improve food production led him to perform advanced research on the beneficial symbionts of land plants and fish. In 2022, he started a novel aquaculture and molecular microbiology laboratory at EST-IPS. Currently, he is focused on the suppression of shellfish/fish diseases caused by opportunistic bacteria in aquaculture using microbiome therapy to sustainably manage human-made ecosystems.

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Identification

Personal identification

Full name: Nuno Miguel Formiga Borges

Citation names

Borges, Nuno

Author identifiers

Ciência ID: 4D1C-299C-14B6
ORCID iD: 0000-0002-3277-8517

Email addresses

nuno.borges@estsetubal.ips.pt (Professional)
nuno.borges@estsetubal.ips.pt (Personal)

Addresses

Instituto Politécnico de Setúbal, Escola Superior de Tecnologia de Setúbal, Departamento de Sistemas e Informática. Campus IPS, Estefanilha, 2914-508, Setúbal, Setúbal, Portugal (Professional)

Knowledge fields

Agrarian Sciences - Agriculture, Forestry and Fisheries

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2018/08/09 Concluded	Contabilidade e Administração (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Contabilidade e Administração de Lisboa, Portugal	16/20
2004 Concluded	Biochemistry (Doutoramento) Major in Especialidade: Bioquímica Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal "The Role of Mannosylglycerate in Thermo- and Osmo-adaptation of Rhodothermus Marinus: Biosynthesis, Regulation and Applications" (THESIS/DISSERTATION)
1998/10/19 Concluded	Biochemistry (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal	16/20

Affiliation

Science

	Category Host institution	Employer
2023 - Current	Auxiliary Researcher (Research)	MARE-IPS (Marine and Environmental Sciences Centre - Polytechnic Institute of Setúbal, Portugal), Portugal

2021/10/01 - 2022/06/30	Contracted Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/03/28 - 2021/09/30	Contracted Researcher (Research)	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2008/03/01 - 2018/02/28	Auxiliary Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

2004/08/01 - 2008/02/29	Postdoc (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2022/03/01 - Current	Invited Adjunct Teacher (Polytechnic Teacher)	Instituto Politécnico de Setúbal, Portugal
	Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal

Projects

Grant

	Designation	Funders
2007/10/01 - 2008/02/29	UNDERSTANDING HOW THE HYPERTHERMOPHILIC ARCHAEA SENSE AND RESPOND TO STRESS SFRH/BPD/36653/2007	Fundação para a Ciência e a Tecnologia Concluded
2004/08/01 - 2007/07/31	HEAT STRESS RESPONSE IN RHODOTHERMUS MARINUS: CHEMICAL AND MOLECULAR CHAPERONES IN THERMO AND OSMO- -ADAPTATION SFRH/BPD/14841/2003	Fundação para a Ciência e a Tecnologia Concluded
1999/10/01 - 2003/09/30	METABOLISMO DE CARBOHIDRATOS E RESPECTIVA ENZIMOLOGIA EM ARQUEBACTÉRIAS HIPERTERMÓFILAS PRAXIS XXI/BD/19868/99	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2023/06/21 - 2029/06/20	Untitled CEECINST/00036/2021/CP2776/CT0004 10.54499/CEECINST/00036/2021/CP2776/CT0004 Researcher Instituto Politécnico de Setúbal, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal INESC Microsistemas e Nanotecnologias, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal INESC Microsistemas e Nanotecnologias, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2023/12/31	Harnessing the catalyst power of host-microbe interactions: a quest for novel chitinases from octocoral symbionts EXPL/BIA-MIC/0286/2021 10.54499/EXPL/BIA-MIC/0286/2021 Researcher Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDP/04378/2020 10.54499/UIDP/04378/2020 UIDB/04378/2020 10.54499/UIDB/04378/2020 Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade do Porto, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal INESC Microsistemas e Nanotecnologias, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/09/29 - 2022/09/28	Exploiting the healing capacity of nature?s microbiomes for improved fish larviculture PTDC/BIA-MIC/31996/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Instituto Português do Mar e da Atmosfera, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/03/28 - 2022/09/09	Exploiting the healing capacity of nature´s microbiomes for improved fish larviculture (MicroControl) PTDC/BIA-MIC/31996/2017 Researcher Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/12 - 2022/06/30	Unravelling the biosynthesis of inositol-phospholipids in M. tuberculosis as a crucial step towards the development of novel anti-tuberculosis drugs PTDC/BIA-BQM/31031/2017 Researcher Universidade NOVA de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/12 - 2022/06/30	Unravelling the biosynthesis of inositol-phospholipids in M. tuberculosis as a crucial step towards the development of novel anti-tuberculosis drugs PTDC/BIA-BQM/31031/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Molecular, Structural and Cellular Microbiology UID/CBQ/04612/2019 Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Molecular, Structural and Cellular Microbiology UID/CBQ/04612/2019 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07/01 - 2016/06/30	NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics RECI/BBB-BQB/0230/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2016	Structural investigation of the anti-tuberculosis drug target phosphatidylinositol phosphate synthase PTDC/BBB-BEP/2532/2012 Post-doc Fellow	Fundação para a Ciência e a Tecnologia Concluded
2013/05/01 - 2015/10/31	Structural investigation of the anti-tuberculosis drug target phosphatidylinositol phosphate synthase (PIPS) PTDC/BBB-BEP/2532/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/03/01 - 2013/08/31	Nitrogen-fixing biofertilizers for gramineous crops PTDC/AGR-AAM/100577/2008 Instituto Nacional de Investigação Agrária e Veterinária, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/03/01 - 2013/02/28	Understanding how hyperthermophilic archaea sense and respond to heat stress: the role of unique polyolphosphodiester compounds PTDC/BIA-MIC/71146/2006 Post-doc Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/03/01 - 2013/02/28	Understanding how hyperthermophilic archaea sense and respond to heat stress CONT_DOUT/35/ITQB/2621/6099/ 9/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2013	Nitrogen-fixing biofertilizers for gramineous crops. PTDC/AGR-AAM/100577/2008 Principal investigator	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 4 - 2011-2012 PEst-OE/EQB/LA0004/2011 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade Nova de Lisboa Medical School, Portugal Fundação Calouste Gulbenkian, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/05/05 - 2012/04/30	Understanding how hyperthermophilic microorganisms cope with heat stress: the role of unique polyolphosphodiester compounds PTDC/BIA-MIC/71146/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2010	Molecular Adaptation to Extreme Environments: Structural Studies of Proteins Involved in the Synthesis of Osmolytes in (hyper)thermophylic micro-organisms PTDC/QUI/71142/2006 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded
2005/01/01 - 2008/04/30	Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp. POCI/BIA-MIC/56511/2004 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	Strategies of life adaptation to hot environments: Heat and osmotic stress responses in the extremely thermophilic bacterium Rhodothermus marinus POCI/BIA-MIC/59310/2004 Principal investigator	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	Lessons from the physiology of hyperthermophilic microorganisms: potential of new biomolecules to inhibit protein misfolding and aggregation POCI V.5.1 A004/2005 POCI V.5.1 A004/2005 Post-doc Fellow	Fundação para a Ciência e a Tecnologia N/A
2005 - 2008	Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp. POCI/BIA-MIC/56511/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/06/15 - 2007/10/14	Strategies of life adaptation to hot environments: Heat and osmotic stress responses in the extremely thermophilic bacterium Rhodothermus marinus POCI/BIA-MIC/59310/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004 - 2006	HOTSOLUTES - New applications for compatible solutes from extremophiles COOP-CT-2003-508644 Post-doc Fellow	European Commission
2001 - 2004	Towards the Utilization of Cell-Reactors for the Production of Mannosylglycerate, an Enzyme Stabilizer from Hyperthermophiles POCTI 35715/BIO/2000 PhD Student Fellow	Fundação para a Ciência e a Tecnologia
2001 - 2004	Exploiting New Solutes from Hyperthermophiles for the Preservation of Biomaterials: Cell Factories for Production of Hypersolutes QLK3-CT-2000-00640 PhD Student Fellow
2000 - 2002	Exploração de Solutos de Organismos Hipertermófilos com vista à sua Utilização como Estabilizantes de Enzimas PRAXIS/P/BIO/12082/1998 PhD Student Fellow	Fundação para a Ciência e a Tecnologia
1996 - 1999	Extremophiles as Cell Factories BIO 4-CT 960488 PhD Student Fellow	European Commission
1996 - 1999	Estratégias Bioquímicas de Termo-Estabilização em Microrganismos Hipertermófilos PRAXIS/2/2.1/BIO/1109/95 PhD Student Fellow	Fundação para a Ciência e a Tecnologia
1994 - 1998	Microrganismos em Ambientes Extremos: Mecanismos de Adaptação PRAXIS/2/2.1/BIO/20/94 Scientific Initiation Fellow	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Santos, H; Lamosa, P.; Borges, Nuno; Gonçalves, L.G.; Pais, T.M.; Rodrigues, M.V.. "Organic compatible solutes of prokaryotes that thrive in hot environments: the importance of ionic compounds for thermostabilization". In Extremophiles Handbook. 2011. Published • 10.1007/978-4-431-53898-1_23 Santos, Helena; Lamosa, Pedro; Faria, Tiago Q.; Borges, Nuno; Neves, ClÉlia. "The Physiological Role, Biosynthesis, and Mode of Action of Compatible Solutes from (Hyper)Thermophiles". In Physiology and Biochemistry of Extremophiles, 86-103. American Society of Microbiology, 2007. 10.1128/9781555815813.ch7 Santos, H.; Lamosa, P.; Borges, N.. "Characterization and Quantification of Compatible Solutes in (Hyper)thermophilic Microorganisms". 2006. 10.1016/S0580-9517(08)70011-4
Conference paper	Galhanas, D.; Mata, Ana M. T.; Borges, Nuno; Simões, Manuela; Manuela Silvestre; Salgado, R.. "Effect of oyster pseudofaeces on water and oyster quality during the cultivation process". Beja, 2024. Accepted
Journal article	Nobre, Rodrigo N.; Esteves, Ana M.; Borges, Nuno; Rebelo, Sara; Liu, Yaqi; Mancia, Filippo; Santos, Helena. "Production and Purification of Phosphatidylinositol Mannosides from Mycobacterium smegmatis Biomass". Current Protocols 2 6 (2022): http://dx.doi.org/10.1002/cpz1.458. 10.1002/cpz1.458 Borges, Nuno. "Bacteriome Structure, Function, and Probiotics in Fish Larviculture: The Good, the Bad, and the Gaps.". Annual review of animal biosciences (2020): https://doi.org/10.1146/annurev-animal-062920-113114. 10.1146/annurev-animal-062920-113114 Borges, Nuno. "Metagenome-Assembled Genome Sequences of Three Uncultured Planktomarina sp. Strains from the Northeast Atlantic Ocean.". Microbiology resource announcements (2020): https://europepmc.org/articles/PMC7082456. 10.1128/mra.00127-20 Borges, Nuno; Pastor, José M.; Borges, Nuno; Pagán, Juan P.; Castaño-Cerezo, Sara; Csonka, Laszlo N.; Goodner, Bradley W.; et al. "Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden-Meyerhof-Parnas and Entner-Doudoroff pathways". Microbial Cell Factories 18 1 (2019): http://dx.doi.org/10.1186/s12934-019-1178-x. 10.1186/s12934-019-1178-x Esteves, A.M.; Graça, G.; Peyriga, L.; Torcato, I.M.; Borges, N.; Portais, J.-C.; Santos, H.. "Combined transcriptomics–metabolomics profiling of the heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus". Extremophiles 23 1 (2019): 101-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056482652&partnerID=MN8TOARS. 10.1007/s00792-018-1065-0 Faria, C.; Borges, N.; Rocha, I.; Santos, H.. "Production of mannosylglycerate in Saccharomyces cerevisiae by metabolic engineering and bioprocess optimization". Microbial cell factories 17 1 (2018): 178-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056705726&partnerID=MN8TOARS. 10.1186/s12934-018-1023-7 Castanheira, N.L.; Dourado, A.C.; Pais, I.; Semedo, J.; Scotti-Campos, P.; Borges, N.; Carvalho, G.; Barreto Crespo, M.T.; Fareleira, P.. "Colonization and beneficial effects on annual ryegrass by mixed inoculation with plant growth promoting bacteria". Microbiological Research 198 (2017): 47-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013661457&partnerID=MN8TOARS. 10.1016/j.micres.2017.01.009 Rodrigues, M.V.; Borges, N.; Santos, H.. "Glycerol phosphate cytidylyltransferase stereospecificity is key to understanding the distinct stereochemical compositions of glycerophosphoinositol in Bacteria and Archaea". Applied and Environmental Microbiology 83 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009964403&partnerID=MN8TOARS. 10.1128/AEM.02462-16 Castanheira, N.; Dourado, A.C.; Kruz, S.; Alves, P.I.L.; Delgado-Rodríguez, A.I.; Pais, I.; Semedo, J.; et al. "Plant growth-promoting Burkholderia species isolated from annual ryegrass in Portuguese soils". Journal of Applied Microbiology 120 3 (2016): 724-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959038102&partnerID=MN8TOARS. 10.1111/jam.13025 Jorge, C.D.; Borges, N.; Bagyan, I.; Bilstein, A.; Santos, H.. "Potential applications of stress solutes from extremophiles in protein folding diseases and healthcare". Extremophiles 20 3 (2016): 251-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963670607&partnerID=MN8TOARS. 10.1007/s00792-016-0828-8 Jorge, C.D.; Borges, N.; Santos, H.. "A novel pathway for the synthesis of inositol phospholipids uses cytidine diphosphate (CDP)-inositol as donor of the polar head group". Environmental Microbiology 17 7 (2015): 2492-2504. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937073217&partnerID=MN8TOARS. 10.1111/1462-2920.12734 Nádia Castanheira; Ana Catarina Dourado; Paula Isabel Alves; Alícia Maria Cortés-Pallero; Ana Isabel Delgado-Rodríguez; Ângela Prazeres; Nuno Borges; et al. "Annual ryegrass-associated bacteria with potential for plant growth promotion". Microbiological Research 169 9-10 (2014): 768-779. http://dx.doi.org/10.1016/j.micres.2013.12.010. 10.1016/j.micres.2013.12.010 Borges, N.; Jorge, C.D.; Gonçalves, L.G.; Gonçalves, S.; Matias, P.M.; Santos, H.. "Mannosylglycerate: structural analysis of biosynthesis and evolutionary history". Extremophiles 18 5 (2014): 835-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929510245&partnerID=MN8TOARS. 10.1007/s00792-014-0661-x Nogly, P.; Gushchin, I.; Remeeva, A.; Esteves, A.M.; Borges, N.; Ma, P.; Ishchenko, A.; et al. "X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903147718&partnerID=MN8TOARS. 10.1038/ncomms5169 Esteves, A.M.; Chandrayan, S.K.; McTernan, P.M.; Borges, N.; Adams, M.W.W.; Santos, H.. "Mannosylglycerate and di-myo-inositol phosphate have interchangeable roles during adaptation of Pyrococcus furiosus to heat stress". Applied and Environmental Microbiology 80 14 (2014): 4226-4233. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903182320&partnerID=MN8TOARS. 10.1128/AEM.00559-14 Quintas, P.O.; Cepeda, A.P.; Borges, N.; Catarino, T.; Turner, D.L.. "Relative importance of driving force and electrostatic interactions in the reduction of multihaem cytochromes by small molecules". Biochimica et Biophysica Acta - Bioenergetics 1827 6 (2013): 745-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875943702&partnerID=MN8TOARS. 10.1016/j.bbabio.2013.02.006 Faria, C.; Jorge, C.D.; Borges, N.; Tenreiro, S.; Outeiro, T.F.; Santos, H.. "Inhibition of formation of a-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease". Biochimica et Biophysica Acta - General Subjects 1830 8 (2013): 4065-4072. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877839143&partnerID=MN8TOARS. 10.1016/j.bbagen.2013.04.015 Gonçalves, L.G.; Borges, N.; Serra, F.; Fernandes, P.L.; Dopazo, H.; Santos, H.. "Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments". Environmental Microbiology 14 3 (2012): 691-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857855641&partnerID=MN8TOARS. 10.1111/j.1462-2920.2011.02621.x Gonçalves, S.; Esteves, A.M.; Santos, H.; Borges, N.; Matias, P.M.. "Three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from thermus thermophilus HB27: A new member of the haloalcanoic acid dehalogenase superfamily". Biochemistry 50 44 (2011): 9551-9567. http://www.scopus.com/inward/record.url?eid=2-s2.0-80155206893&partnerID=MN8TOARS. 10.1021/bi201171h Brito, J.A.; Borges, N.; Vonrhein, C.; Santos, H.; Archer, M.. "Crystal structure of archaeoglobus fulgidus CTP:Inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles". Journal of Bacteriology 193 9 (2011): 2177-2185. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955532914&partnerID=MN8TOARS. 10.1128/JB.01543-10 Gonçalves, S.; Esteves, A.M.; Borges, N.; Santos, H.; Matias, P.M.. "Crystallization and preliminary X-ray analysis of mannosyl-3- phosphoglycerate phosphatase from Thermus thermophilus HB27". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 3 (2011): 390-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952692197&partnerID=MN8TOARS. 10.1107/S1744309111002843 Borges, N.; Matsumi, R.; Imanaka, T.; Atomi, H.; Santos, H.. "Thermococcus kodakarensis mutants deficient in di-myo-inositol phosphate use aspartate to cope with heat stress". Journal of Bacteriology 192 1 (2010): 191-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-73849124968&partnerID=MN8TOARS. 10.1128/JB.01115-09 Brito, J.A.; Borges, N.; Santos, H.; Archer, M.. "Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidylyltransferase from Archaeoglobus fulgidus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 11 (2010): 1463-1465. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149345319&partnerID=MN8TOARS. 10.1107/S1744309110032677 Gonçalves, S.; Borges, N.; Esteves, A.M.; Victor, B.L.; Soares, C.M.; Santos, H.; Matias, P.M.. "Structural analysis of Thermus thermophilus HB27 mannosyl-3- phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases". Journal of Biological Chemistry 285 23 (2010): 17857-17868. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952938697&partnerID=MN8TOARS. 10.1074/jbc.M109.095976 Gonçalves, S.; Borges, N.; Santos, H.; Matias, P.M.. "Crystallization and preliminary x-ray analysis of mannosyl-3- phosphoglycerate synthase from thermus thermophilus HB27". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 10 (2009): 1014-1017. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350312647&partnerID=MN8TOARS. 10.1107/S1744309109032576 Rodrigues, M.V.; Borges, N.; Almeida, C.P.; Lamosa, P.; Santos, H.. "A unique ß-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor". Journal of Bacteriology 191 19 (2009): 6105-6115. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349096860&partnerID=MN8TOARS. 10.1128/JB.00598-09 Rodrigues, M.V.; Borges, N.; Henriques, M.; Lamosa, P.; Ventura, R.; Fernandes, C.; Empadinhas, N.; et al. "Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol: Inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles". Journal of Bacteriology 189 15 (2007): 5405-5412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547629796&partnerID=MN8TOARS. 10.1128/JB.00465-07 Cardoso, F.S.; Castro, R.F.; Borges, N.; Santos, H.. "Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response". Microbiology 153 1 (2007): 270-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846305426&partnerID=MN8TOARS. 10.1099/mic.0.29262-0 Borges, N.; Gonçalves, L.G.; Rodrigues, M.V.; Siopa, F.; Ventura, R.; Maycock, C.; Lamosa, P.; Santos, H.. "Biosynthetic pathways of inositol and glycerol phosphodiesters used by the hyperthermophile Archaeoglobus fulgidus in stress adaptation". Journal of Bacteriology 188 23 (2006): 8128-8135. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751559039&partnerID=MN8TOARS. 10.1128/JB.01129-06 Borges, N.; Marugg, J.D.; Empadinhas, N.; Da Costa, M.S.; Santos, H.. "Specialized Roles of the Two Pathways for the Synthesis of Mannosylglycerate in Osmoadaptation and Thermoadaptation of Rhodothermus marinus". Journal of Biological Chemistry 279 11 (2004): 9892-9898. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642279326&partnerID=MN8TOARS. 10.1074/jbc.M312186200 Borges, N.; Ramos, A.; Raven, N.D.H.; Sharp, R.J.; Santos, H.. "Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes". Extremophiles 6 3 (2002): 209-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036599177&partnerID=MN8TOARS. 10.1007/s007920100236 Empadinhas, N.; Marugg, J.D.; Borges, N.; Santos, H.; Da Costa, M.S.. "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes". Journal of Biological Chemistry 276 47 (2001): 43580-43588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941355&partnerID=MN8TOARS. 10.1074/jbc.M108054200 Cánovas, D.; Borges, N.; Vargas, C.; Ventosa, A.; Nieto, J.J.; Santos, H.. "Role of N-gama-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine". Applied and Environmental Microbiology 65 9 (1999): 3774-3779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032586949&partnerID=MN8TOARS. Silva, Z.; Borges, N.; Martins, L.O.; Wait, R.; Da Costa, M.S.; Santos, H.. "Combined effect of the growth temperature and salinity of the medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis". Extremophiles 3 2 (1999): 163-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033136552&partnerID=MN8TOARS. 10.1007/s007920050112

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021/02/04	Oral Poster Presentation: Identification and characterization of bacteria with hydrolytic and antibacterial activities isolated from gilthead sea bream (Sparus aurata) for application as probiotics in larviculture.	1st Microbiome PT Summit BioData.pt and ELIXIR-PT, Online event (Lisbon, Portugal)
2012/09/11	Biosynthesis, evolution and role of unique compatible solutes in heat stress adaptation of marine hyperthermophiles	The 9th International Conference on Extremophiles, September, 10-13, 2012, Sevilla, Spain (Sevilla, Spain)
2011/09/11	Role, evolution, and regulation of the synthesis of di-myo-inositol-phosphate in hyperthermophiles	The 11th International Conference on Thermophiles Research, September, 11-16, 2011, Big Sky, Montana, EUA. (Montana, United States)
2008/09/10	Kinetic and structural characterization of the enzymes involved in the synthesis of di-myo-inositol-phosphate in Archaeoglobus fulgidus.	The 7th International Conference on Extremophiles, 7-11, September, 2008, Cape Town, South africa (Cape Town, South Africa)
2005/12/01	The role of compatible solutes in osmoadaptation and thermoadaptation of the thermophilic bacterium Rhodothermus marinus: Biosynthesis and regulation	MICRO’05:BIOTEC’05, 30 Nov-3 Dec, 2005, Póvoa do Varzim, Portugal. (Póvoa do Varzim, Portugal)
2004/09/20	Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus	The 5th international conference on extremophiles, 19-23, September, 2004, Cambridge, Maryland, EUA. (Maryland, United States)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023 - Current	Jeinny Caetano (Undergraduate student) Análise da presença de celulose em ETAR: Caso de estudo ETAR Setúbal Supervisor	Instituto Politécnico de Setúbal, Portugal
2023 - 2023	Fábio Guerreiro (Undergraduate Student) Produção de uma Ração com Proteína de Cavala para Robalos e Douradas Supervisor	Instituto Politécnico de Setúbal, Portugal
2023 - 2023	Diogo Colimão (Undergraduate Student) Produção de ração para aquacultura Supervisor	Instituto Politécnico de Setúbal, Portugal
2020 - 2020	André Magalhães (Master Student) Exploiting the healing capacity of nature´s microbiomes for improved fish well-being in aquaculture Co-supervisor of André Magalhães	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2013 - 2018	Nádia Castanheira (PhD Student) Nitrogen-fixing biofertilizers for gramineous crops Supervisor of Nádia Castanheira	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2017	Cristiana Faria (PhD Student) Development of cell factories for the efficient production of mannosylglycerate, a thermolyte with great potential in biotechnology Co-supervisor of Cristiana Faria	Universidade Nova de Lisboa, Portugal
2010 - 2014	Ana M Esteves (PhD Student) Unravelling the regulatory mechanisms in thermo-adaptation of hyperthermophilic archaea Co-supervisor of Ana M Esteves	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - 2013	Rute Pinto (Undergraduate Student) Cloning, expression and purification of a protein involved in the synthesis of a compound accumulated in heat tress response in hyperthermophiles. Supervisor of Rute Pinto	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - 2011	Marta V Rodrigues (PhD Student) Heat Stress Adaptation in Hyperthermophiles: Biosynthesis of Inositol-Containing Compatible Solutes Co-supervisor of Marta V Rodrigues	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009 - 2010	Cristiana Silva Faria (Master Student) Engineering Saccharomyces cerevisiae for the production of mannosylglycerate - a yeast model for assessing its application in protein stabilization Co-supervisor of Cristiana Faria	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008 - 2009	Sónia Neto (Master Student) Unravelling Cell-to-Cell Communication in Archaea Co-supervisor of Sónia Neto	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2006	Mafalda Henriques (Undergraduate Student) Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/ CDP inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles Co-supervisor of Mafalda Henriques	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023 - 2023	"A Celebration of Structural Biology" 14 April 2023, Academia da Ciências de Lisboa, Lisbon, Portugal, Organization: Maria Salomé Pais, Helena Santos, Nuno Borges e Ana Esteves. (2023 - 2023) Seminar (Co-organisor)	Academia das Ciências de Lisboa, Portugal
2014 - 2014	"Bioprospecting hot springs in Azores Meeting" October 2014, CiiMAR, Porto, Portugal. H. Santos, V. Vasconcelos, N. Borges, F. do Valle. (2014 - 2014) Meeting (Co-organisor)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2010/09/12 - 2010/09/16	The 8th International Conference on Extremophiles, September, 12-16, 2010, Ponta Delgada, Azores, Portugal. H. Santos (Chair), N. Borges (Co-chair), P. Lamosa (Co-chair). (2010/09/12 - 2010/09/16) Congress (Co-organisor)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023 - 2023	SIMBA - Sustainable Innovation of Microbiome Applications in the Food System, University of Copenhagen, Denmark, 28 September 2023. Symposium	SIMBA - Sustainable Innovation of Microbiome Applications in the Food System IT-Universitet i København, Denmark
2023 - 2023	LIFE INVASAQUA organizado pelo CINEA-IPS (Escola Superior de Tecnologia de Setúbal, IPS) e LIFE INVASAQUA (Universidade de Évora/MARE/ARNET), 10 março 2023 Symposium	LIFE INVASAQUA Instituto Politécnico de Setúbal, Portugal
2019 - 2019	Keep in Touch 2019, May 23, 2019, Instituto Superior Técnico, Lisbon, Portugal Other	Keep in Touch 2019 Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2019	Dia do Mar, Museu Nacional de História Natural e da Ciência, 16 November 2019, Lisbon, Portugal	Dia do Mar Museu Nacional de História Natural e da Ciência, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019/12	Patricia Lobato Calafate Paula, Assessment of antimicrobial activities of marine bacteria against human pathogens (Thesis) Main arguer	Patricia Lobato Calafate Paula (Master) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2023 - Current	Reviews in Aquaculture (1753-5123)	wiley
2022 - Current	Scientific Reports (2045-2322)	Nature
2021 - Current	3 Biotech (2190-5738)	Springer
2021 - Current	Microbiome (2049-2618)	Springer Nature
2009 - Current	Extremophiles (1433-4909)	Springer-Verlag
2009 - Current	Research in Microbiology (0923-2508)	Elsevier

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024 - Current	Co-coordinator and teaches laboratory practical in the Curricular Unit “Food Safety in Aquaculture"	(Mestrado)	Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2022 - Current	Coordinator and teaches theory in the Curricular Unit “Environmental and food microbiology"	(Curso Técnico Superior Profissional)	Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2021 - Current	Coordinator and teaches theory in the Curricular Unit "Environmental Microbiology"	(Licenciatura)	Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2022 - 2022	Teaches laboratory practical in the Curricular Unit "Biochemistry"	(Licenciatura)	Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2005 - 2005	The Role of Compatible Solutes in Osmoadaptation and Thermoadaptation of the Thermophilic Bacterium Rhodothermus marinus (Module: Microbiology of Extreme Environments)	(Doutoramento)	Centro de Neurociências e Biologia Celular at Coimbra University, Portugal
2005 - 2005	Proteomics: Principles and Applications (Module: Metabolic engineering)	(Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Distinctions

Award

2007	Prémio Câmara Pestana 2007 Instituto Bacteriológico Câmara Pestana and GlaxoSmithKline, Portugal