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Vishal Rai. Completed the Doctor of Philosophy in Ph.D. in 2008 by Indian Institute of Technology Bombay, Master in M.Sc. in 2003 by Banaras Hindu University and Bachelor in B.Sc. in 2001 by Banaras Hindu University. Is Principal Investigator in Indian Institute of Science Education and Research Bhopal. Published 28 articles in journals. Supervised 6 PhD thesis(es). Supervised 6 MSc dissertation(s). Has received 6 awards and/or honors. Participates and/or participated as Principal investigator in 9 project(s). Works in the area(s) of Exact Sciences with emphasis on Chemical Sciences.
Identification

Personal identification

Full name
Vishal Rai

Citation names

  • Rai, Vishal

Author identifiers

Ciência ID
4D1F-3CCD-E111
ORCID iD
0000-0002-6078-3516

Telephones

Mobile phone
  • (+91) 7566189001 (Personal)
Telephone
  • (+91) 7552691339 (Professional)

Addresses

  • C334, Academic Building II, Department of Chemistry, IISER Bhopal, Bhopal Bypass Road, Bhauri, 462066, Bhopal, Bhopal, India (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Hindi (Mother tongue)
Education
Degree Classification
2003 - 2008
Concluded
 Ph.D. (Doctor of Philosophy)
Major in Organic Chemistry
Indian Institute of Technology Bombay, India
2001 - 2003
Concluded
 M.Sc. (Master)
Major in Organic Chemistry
Banaras Hindu University, India
1998 - 2001
Concluded
 B.Sc. (Bachelor)
Major in Chemistry
Banaras Hindu University, India
Affiliation

Science

Category
Host institution 		Employer
2011 - Current Principal Investigator (Research) Indian Institute of Science Education and Research Bhopal, India
Indian Institute of Science Education and Research Bhopal, India
2008 - 2011 Postdoc (Research) University of Toronto Department of Chemistry, Canada
University of Toronto Department of Chemistry, Canada
Outputs

Publications

Journal article
  1. Rai, Vishal; Srinivasa Rao Adusumalli; Dattatraya Gautam Rawale; Kalyani Thakur; Landa Purushottam; Neelesh C. Reddy; Neetu Kalra; Sanjeev Shukla; Vishal Rai. "Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins". Angewandte Chemie International Edition 132 26 (2020): 10418-10422. http://dx.doi.org/10.1002/anie.202000062.
    10.1002/anie.202000062
  2. Neelesh C. Reddy; Mohan Kumar; Rajib Molla; Vishal Rai. "Chemical methods for modification of proteins". Organic & Biomolecular Chemistry (2020): https://doi.org/10.1039/D0OB00857E.
    10.1039/D0OB00857E
  3. Landa Purushottam; Srinivasa Rao Adusumalli; Usha Singh; V. B. Unnikrishnan; Dattatraya Gautam Rawale; Mansi Gujrati; Ram Kumar Mishra; Vishal Rai. "Single-site glycine-specific labeling of proteins". Nature Communications 10 1 (2019): https://doi.org/10.1038/s41467-019-10503-7.
    10.1038/s41467-019-10503-7
  4. Dattatraya G. Rawale; Kalyani Thakur; Srinivasa Rao Adusumalli; Vishal Rai. "Chemical Methods for Selective Labeling of Proteins". European Journal of Organic Chemistry 2019 40 (2019): 6749-6763. https://doi.org/10.1002/ejoc.201900801.
    10.1002/ejoc.201900801
  5. Pralhad Namdev Joshi; Vishal Rai. "Single-site labeling of histidine in proteins, on-demand reversibility, and traceless metal-free protein purification". Chemical Communications (2019): https://doi.org/10.1039/C8CC08733D.
    10.1039/C8CC08733D
  6. Rohith Singudas; Neelesh C. Reddy; Vishal Rai. "Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates". Chemical Communications (2019): https://doi.org/10.1039/C9CC03424B.
    10.1039/C9CC03424B
  7. Srinivasa Rao Adusumalli; Dattatraya Gautam Rawale; Usha Singh; Prabhanshu Tripathi; Rajesh Paul; Neetu Kalra; Ram Kumar Mishra; Sanjeev Shukla; Vishal Rai. "Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology". Journal of the American Chemical Society (2018): https://doi.org/10.1021/jacs.8b10490.
    10.1021/jacs.8b10490
  8. Srinivasa Rao Adusumalli; Dattatraya Gautam Rawale; Vishal Rai. "Aldehydes can switch the chemoselectivity of electrophiles in protein labeling". Organic & Biomolecular Chemistry (2018): https://doi.org/10.1039/C8OB02897D.
    10.1039/C8OB02897D
  9. Maheshwerreddy Chilamari; Neetu Kalra; Sanjeev Shukla; Vishal Rai. "Single-site labeling of lysine in proteins through a metal-free multicomponent approach". Chemical Communications (2018): https://doi.org/10.1039/C8CC03311K.
    10.1039/C8CC03311K
  10. Maheshwerreddy Chilamari; Landa Purushottam; Vishal Rai. "Site-Selective Labeling of Native Proteins by a Multicomponent Approach". Chemistry - A European Journal 23 16 (2017): 3819-3823. https://doi.org/10.1002%2Fchem.201605938.
    10.1002/chem.201605938
  11. Landa Purushottam; Srinivasa Rao Adusumalli; Maheshwerreddy Chilamari; Vishal Rai. "Chemoselective and site-selective peptide and native protein modification enabled by aldehyde auto-oxidation". Chem. Commun. 53 5 (2017): 959-962. https://doi.org/10.1039%2Fc6cc09555k.
    10.1039/c6cc09555k
  12. Pralhad N. Joshi; Landa Purushottam; Nirmal K. Das; Saptarshi Mukherjee; Vishal Rai. "Protein self-assembly induces promiscuous nucleophilic biocatalysis in Morita–Baylis–Hillman (MBH) reaction". RSC Adv. 6 1 (2016): 208-211. https://doi.org/10.1039%2Fc5ra23949d.
    10.1039/c5ra23949d
  13. Serge Zaretsky; Vishal Rai; Gerald Gish; Matthew W. Forbes; Michael Kofler; Joy C. Y. Yu; Joanne Tan; et al. "Twisted amide electrophiles enable cyclic peptide sequencing". Org. Biomol. Chem. 13 27 (2015): 7384-7388. https://doi.org/10.1039%2Fc5ob01050k.
    10.1039/c5ob01050k
  14. Rohith Singudas; Srinivasa Rao Adusumalli; Pralhad Namdev Joshi; Vishal Rai. "A phthalimidation protocol that follows protein defined parameters". Chem. Commun. 51 3 (2015): 473-476. https://doi.org/10.1039%2Fc4cc08503e.
    10.1039/c4cc08503e
  15. Benjamin H. Rotstein; Serge Zaretsky; Vishal Rai; Andrei K. Yudin. "ChemInform Abstract: Small Heterocycles in Multicomponent Reactions". ChemInform 45 41 (2014): no-no. https://doi.org/10.1002%2Fchin.201441280.
    10.1002/chin.201441280
  16. Benjamin H. Rotstein; Serge Zaretsky; Vishal Rai; Andrei K. Yudin. "Small Heterocycles in Multicomponent Reactions". Chemical Reviews 114 16 (2014): 8323-8359. https://doi.org/10.1021%2Fcr400615v.
    10.1021/cr400615v
  17. Conor C. G. Scully; Vishal Rai; Gennadiy Poda; Serge Zaretsky; Darcy C. Burns; R. Scott Houliston; Tiantong Lou; Andrei K. Yudin. "Bending Rigid Molecular Rods: Formation of Oligoproline Macrocycles". Chemistry - A European Journal 18 49 (2012): 15612-15617. https://doi.org/10.1002%2Fchem.201203266.
    10.1002/chem.201203266
  18. Benjamin H Rotstein; Vishal Rai; Ryan Hili; Andrei K Yudin. "Synthesis of peptide macrocycles using unprotected amino aldehydes". Nature Protocols 5 11 (2010): 1813-1822. https://doi.org/10.1038%2Fnprot.2010.127.
    10.1038/nprot.2010.127
  19. Mais J. Jebrail; Alphonsus H. C. Ng; Vishal Rai; Ryan Hili; Andrei K. Yudin; Aaron R. Wheeler. "Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics". Angewandte Chemie International Edition 49 46 (2010): 8625-8629. https://doi.org/10.1002%2Fanie.201001604.
    10.1002/anie.201001604
  20. Mais J. Jebrail; Alphonsus H. C. Ng; Vishal Rai; Ryan Hili; Andrei K. Yudin; Aaron R. Wheeler. "Innentitelbild: Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics (Angew. Chem. 46/2010)". Angewandte Chemie 122 46 (2010): 8716-8716. https://doi.org/10.1002%2Fange.201004588.
    10.1002/ange.201004588
  21. Mais J. Jebrail; Alphonsus H. C. Ng; Vishal Rai; Ryan Hili; Andrei K. Yudin; Aaron R. Wheeler. "Inside Cover: Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics (Angew. Chem. Int. Ed. 46/2010)". Angewandte Chemie International Edition 49 46 (2010): 8536-8536. https://doi.org/10.1002%2Fanie.201004588.
    10.1002/anie.201004588
  22. Ryan Hili; Vishal Rai; Andrei K. Yudin. "Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules". Journal of the American Chemical Society 132 9 (2010): 2889-2891. https://doi.org/10.1021%2Fja910544p.
    10.1021/ja910544p
  23. Vishal Rai; Irishi N. N. Namboothiri. "ChemInform Abstract: Enantioselective Conjugate Addition of Dialkyl Phosphites to Nitroalkenes.". ChemInform 40 18 (2009): https://doi.org/10.1002%2Fchin.200918170.
    10.1002/chin.200918170
  24. Vishal Rai; Irishi N.N. Namboothiri. "Enantioselective conjugate addition of dialkyl phosphites to nitroalkenes". Tetrahedron: Asymmetry 19 20 (2008): 2335-2338. https://doi.org/10.1016%2Fj.tetasy.2008.10.010.
    10.1016/j.tetasy.2008.10.010
  25. Vishal Rai; Irishi N.N. Namboothiri. "Effect of achiral and mixed chiral ligands on the asymmetric synthesis of ¿-nitrophosphonates via Michael addition". Tetrahedron: Asymmetry 19 7 (2008): 767-772. https://doi.org/10.1016%2Fj.tetasy.2008.03.006.
    10.1016/j.tetasy.2008.03.006
  26. Vishal Rai; Shaikh M. Mobin; Irishi N. N. Namboothiri. "ChemInform Abstract: Cinchonine-Catalyzed Diastereo- and Enantioselective Michael Addition of a-Lithiated Phosphonates to Nitroalkenes.". ChemInform 39 17 (2008): https://doi.org/10.1002%2Fchin.200817175.
    10.1002/chin.200817175
  27. Vishal Rai; Shaikh M. Mobin; Irishi N.N. Namboothiri. "Cinchonine catalyzed diastereo- and enantioselective Michael addition of a-lithiated phosphonates to nitroalkenes". Tetrahedron: Asymmetry 18 22 (2007): 2719-2726. https://doi.org/10.1016%2Fj.tetasy.2007.11.001.
    10.1016/j.tetasy.2007.11.001
  28. Vishal Rai; Irishi N. N. Namboothiri. "A Theoretical Evaluation of the Michael-Acceptor Ability of Conjugated Nitroalkenes". European Journal of Organic Chemistry 2006 20 (2006): 4693-4703. https://doi.org/10.1002%2Fejoc.200600505.
    10.1002/ejoc.200600505

Other

Other output
  1. Cyclic Peptides. 2013. Srinivasa Rao Adusumalli; Andrei K. Yudin; Vishal Rai. https://doi.org/10.1002%2F9783527666911.ch8.
    10.1002/9783527666911.ch8
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2020 Promiscuous chemoselectivity of electrophiles in single-site protein bioconjugation
Supervisor
 Chemical Biology (Master)
Indian Institute of Science Education and Research Bhopal, India
2013 - 2020 Lysine directed single-site precision engineering of native proteins
Supervisor
 Chemical Biology (PhD)
Indian Institute of Science Education and Research Bhopal, India
2018 - 2019 Site-selective modification of serine proteases enabled by linchpin directed modification
Supervisor
 Chemical Biology (Master)
Indian Institute of Science Education and Research Bhopal, India
2013 - 2019 Aldehyde enabled site-selective protein modification and purification
Supervisor
 Chemical Biology (PhD)
Indian Institute of Science Education and Research Bhopal, India
2012 - 2019 Precision in modification and analysis of proteins by targeting amine and carboxylic acid
Supervisor
 Chemical Biology (PhD)
Indian Institute of Science Education and Research Bhopal, India
2017 - 2018 Design and synthesis of modular protein labeling reagents
Supervisor
 Chemical Biology (Master)
Indian Institute of Science Education and Research Bhopal, India
2017 - 2018 Site-specific linchpin driven site-selective labeling of protein
Supervisor
 Chemical Biology (Master)
Indian Institute of Science Education and Research Bhopal, India
2017 - 2018 Gly-tag for metal-free protein purification
Supervisor
 Chemical Biology (Master)
Indian Institute of Science Education and Research Bhopal, India
2012 - 2018 Single-site labeling of lysine in native proteins through multicomponent approach
Supervisor
 Chemical Biology (PhD)
Indian Institute of Science Education and Research Bhopal, India
2012 - 2018 Catalysis by proteins and their site-selective bioconjugation
Supervisor
 Chemical Biology (PhD)
Indian Institute of Science Education and Research Bhopal, India
2011 - 2017 Single-site labeling of native proteins
Supervisor
 Chemical Biology (PhD)
Indian Institute of Science Education and Research Bhopal, India
2012 - 2013 Chemoselective acyl group transfer methodology
Supervisor
 Chemical Biology (Master)
Indian Institute of Science Education and Research Bhopal, India
Distinctions

Award

2020 Swarnajayanti Fellowship
Department of Science and Technology, India
2012 DAE Young Scientist Award
India Department of Atomic Energy, India
2012 RSC-WIS Young Scientist Award
2011 Ramanujan Fellowship
Department of Science and Technology, India
2010 MITACS Elevate Postdoctoral Fellowship
Mitacs, Canada
2003 CSIR Fellowship
Council of Scientific and Industrial Research Human Resource Development Group, India