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Steve Mendes Catarino completed his PhD in Biomedical Sciecnes in 2010/10/22 at the Faculty of Medicine University of Coimbra. He has published 19 articles in peer-reviewed journals. Co-supervised 2 MSc dissertations. Participates and/or participated as a Researcher in 7 projects and as a Scientific Initiation Fellow in 1 project. SC has been doing research at the Faculty of Medicine University of Coimbra since 2002. His main interests include gap junction communication, protein degradation, intracellular trafficking, extracellular vesicles and cardiovascular sciences. His main scientific contributions include the characterization of the intracellular trafficking, post-translational modifications and degradation of the gap junction protein Cx43, and also the physiological implication of Cx43 in cardiovascular diseases.
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Identification

Personal identification

Full name
Steve Mendes Catarino

Citation names

  • Catarino, Steve

Author identifiers

Ciência ID
4E19-9B38-5F0B
ORCID iD
0000-0001-9644-6960

Telephones

Telephone
  • 239480225 (Professional)

Addresses

  • Azinhaga de Santa Comba, iCBR, Pólo III Universidade de Coimbra, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems

Languages

Language Speaking Reading Writing Listening Peer-review
English (Mother tongue)
Portuguese (Mother tongue)
Education
Degree Classification
2010/10/22
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Sem especialidade
Universidade de Coimbra Faculdade de Medicina, Portugal
"Mind the Gap. a New Molecular Model for the Intercellular Trafficking of Connexin43" (THESIS/DISSERTATION)
1998 - 2003
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2018/12/26 - Current Contracted Researcher (Research) Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Projects

Grant

Designation Funders
2017/10 - 2017/10 A LIR-motif mediated interaction between the gap junction protein Connexin43 and LC3
Action BM1307 - 39607
 European Cooperation in Science and Technology
2011/07/01 - 2017/06/30 ESCRTING GAP JUNCTION EXTERNALIZTION: A NEW MOLECULAR MECHANISM FOR REGULATION OF GAP JUNCTION INTERCELLULAR COMMUNICATION
SFRH/BPD/68749/2010
 Fundação para a Ciência e a Tecnologia
Concluded
2005/02/01 - 2009/01/31 REGULAÇÃO DA COMUNICAÇÃO INTERCELULAR EM CÉLULAS ENDOTELIAIS EM CONDIÇÕES DE HIPERGLICÉMIA - IMPLICAÇÕES NA RETINOPATIA DIABÉTICA
SFRH/BD/20139/2004
Harvard Medical School, United States
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/07/26 - Current On the right side: unveiling the mechanisms of pulmonary hypertension reversability and heart failure progression
PTDC/MEC-CAR/32414/2017
Researcher
Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2002/03/09 - Current Degradation of GLUT1 by ubiquitin proteasome pathway as a novel regulatory mechanism for glucose transport on diabetic retinopathy
info:eu-repo/grantAgreement/FCT/POCI/39142/PT
Scientific Initiation Fellow
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/12/26 - 2024/12/25 Not Available
DL 57/2016/CP1370/CT0084
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/22 - 2022/06/21 A novel mechanism to Re-Pair Heart Failure with Preserved Ejection Fraction (HFpEF) and endothelial damage
PTDC/MED-PAT/32179/2017
Researcher
Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/04/01 - 2015/09/30 An animal model for age-related changes in proteostasis
info:eu-repo/grantAgreement/FCT/COMPETE/118694/PT
PTDC/SAU-ORG/118694/2010
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
2012/04/01 - 2015/06/30 Unravelling the molecular events of gap junction remodelling in ischemic heart
PTDC/SAU-ORG/119296/2010
info:eu-repo/grantAgreement/FCT/COMPETE/119296/PT
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia

Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - UI 3282 - 2011-2012
PEst-C/SAU/UI3282/2011
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/11/15 - 2012/03/13 A new route for endothelial dysfunction on diabetes: From phenotypes to molecules
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/67498/PT
PTDC/SAU-OSM/67498/2006
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2007/12/31 What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy
info:eu-repo/grantAgreement/FCT/3599-PPCDT/82730/PT
POCI/SAU-OBS/57772/2004
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
2005/10/01 - 2007/12/31 Filling in the GAP: the missing link between intercellular communication and diabetic retinopathy.
POCI/SAU-MMO/57216/2004
info:eu-repo/grantAgreement/FCT/POCI/57216/PT
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia

Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Santos, Diogo; Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Girão, Henrique; Catarino, Steve; Barbosa de Melo, Joana; Sarmento-Ribeiro, Ana B.. "Heat shock protein 90 inhibition as a potential therapeutic target in chronic myeloid leukemia". Paper presented in European Hematology Association, 2018.
    Published
  2. Santos, Diogo; Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Catarino, Steve; Girão, Henrique; Barbosa de Melo, Joana; Sarmento-Ribeiro, Ana B.. "The potential therapeutic effect of Heat Shock Protein 90 inhibition in Chronic Myeloid Leukemia". Paper presented in CIMAGO Annual Scientific Meeting 2018, 2018.
    Published
Conference poster
  1. Ribeiro-Rodrigues, Teresa M; Martins-Marques, Tânia; Catarino, Steve; Girao, Henrique. "A new regulatory mechanism of Cx43 degradation in the heart: chaperones enter the stage". Paper presented in SINAL 2019, X Meeting on Signal Transduction, Olhão, Portugal, 2019.
  2. Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Batista-Almeida, Daniela; Abert, Christine; Martens, Sascha; Girao, Henrique. "Direct interaction with LC3 modulates Cx43 degradation in endothelial cells". Paper presented in IGJC 2019, Victoria, British Columbia, Canada, 2019.
  3. Domingues, Neuza; Cristóvão, Beatriz; Zuzarte, Mónica; Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Girao, Henrique. "Unveiling the role of Cx43 in damaged lysosome secretion". Paper presented in EMBO Workshop 2019 - Proteostasis: From organelles to organisms, 2019.
  4. Santos, Diogo; Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Girão, Henrique; Catarino, Steve; Barbosa de Melo, Joana; Sarmento-Ribeiro, Ana B.. "Alvespimycin is a promising drug in resistant Chronic Myeloid Leukemia". Paper presented in 13º YES Meeting, 2018.
  5. Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Urbé, Sylvie; Clague, Michael; Girao, Henrique. "USP8 Regulates Cx43-mediated Intercellular Communication". Paper presented in Proteostatic Mechanisms in Health and Disease, Athens, Greece, 2018.
    10.1158/1538-7445.am2011-1538
  6. Catarino, Steve. "Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  7. Catarino, Steve. "USP8-mediated deubiquitination regulates the life-cycle of Cx43". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  8. Catarino, Steve. "miR-424 and Smurf1: its significance in Pulmonary Arterial Hypertension". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  9. Catarino, Steve. "A new regulatory mechanism of Cx43 degradation in the heart: CMA enters the stage". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  10. Catarino, Steve. "Ubiquitination mediates the selective sorting of Cx43 into EVs". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  11. Catarino, Steve. "EHD regulates the internalizationof Cx43 – a new player of ischemia-induced remodeling of gap junctions in the heart?". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  12. Catarino, Steve. "EHD1 modulates intercellular trafficking of the gap junction protein Connexin43 (Cx43)". Paper presented in 1st Meeting on Vesicular Biology, 2017.
  13. Catarino, Steve. "A new regulatory mechanism of Cx43 degradation in the heart: CMA enters the stage.". Paper presented in 3rd PROTEOSTASIS Action Meeting, 2016.
  14. Catarino, Steve. "EHD regulates the internalization of Cx43 – a new player of ischemia-induced remodelling of gap junctions in the heart.". Paper presented in 3rd PROTEOSTASIS Action Meeting, 2016.
  15. Catarino, Steve. "USP8-mediated deubiquitination regulates the life-cycle of Cx43.". Paper presented in 7th Proteasome and Autophagy workshop, 2016.
  16. Catarino, Steve. "Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy.". Paper presented in VII Annual Meeting of IBILI, 2015.
  17. Catarino, Steve. "Usp8-mediated deubiquitination regulates the life-cycle of Cx43.". Paper presented in VII Annual Meeting of IBILI, 2015.
  18. Catarino, Steve. "MYO7A gene mutation effect in protein-protein interaction.". Paper presented in VII Annual Meeting of IBILI, 2015.
Journal article
  1. Tania Martins-Marques; Katja Witschas; Ilda Ribeiro; Mónica Zuzarte; Steve Catarino; Teresa Ribeiro-Rodrigues; Francisco Caramelo; et al. "Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells". Open Biology (2023): http://dx.doi.org/10.1098/rsob.230258.
    10.1098/rsob.230258
  2. Beatriz Cristovao; Lisa Rodrigues; Steve Catarino; Monica Abreu; Teresa Gonçalves; Neuza Domingues; Girao H. "Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection". Microbiology Spectrum (2023): http://dx.doi.org/10.1128/spectrum.01238-23.
    10.1128/spectrum.01238-23
  3. Raquel Alves; Diogo Santos; Joana Jorge; Ana Cristina Gonçalves; Steve Catarino; Henrique Girão; Joana Barbosa Melo; Ana Bela Sarmento-Ribeiro. "Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines". Molecules (2023): https://doi.org/10.3390/molecules28031210.
    10.3390/molecules28031210
  4. Tania Martins-Marques; Marina C Costa; Steve Catarino; Isaura Simoes; Trond Aasen; Francisco J Enguita; Henrique Girao. "Cx43-mediated sorting of miRNAs into extracellular vesicles". EMBO reports (2022): https://doi.org/10.15252/embr.202154312.
    10.15252/embr.202154312
  5. Aires ID; Ribeiro-Rodrigues T; Boia R; Catarino S; Girão H; Ambrósio AF; Santiago AR. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.". Glia (2020): http://europepmc.org/abstract/med/32645245.
    10.1002/glia.23880
  6. S Catarino; Teresa M Ribeiro-Rodrigues; Rita Sá Ferreira; José Ramalho; Christine Abert; Sascha Martens; Girao H. "A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins". Cells (2020): https://www.mdpi.com/2073-4409/9/4/902.
    10.3390/cells9040902
  7. Martins-Marques T; Catarino S; Gonçalves A; Miranda-Silva D; Gonçalves LM; Antunes PE; Coutinho G; et al. "EHD1 Modulates Cx43 Gap Junction Remodeling Associated with Cardiac Diseases.". Circulation research (2020): http://europepmc.org/abstract/med/32138615.
    10.1161/circresaha.119.316502
  8. Santiago, Ana Raquel; Aires, Ines Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Almeida, Daniela; Girao, Henrique; Ambrosio, Antonio F.. "Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity". Investigative Ophthalmology & Visual Science (2019): https://publons.com/wos-op/publon/28332477/.
  9. Catarino, Steve; Pereira, Paulo; Girão, Henrique; Catarino, S.; Pereira, P.; Girao, H.. "Molecular control of chaperone-mediated autophagy". Essays in Biochemistry 61 6 (2017): 663-674. http://dx.doi.org/10.1042/ebc20170057.
    10.1042/ebc20170057
  10. Baptista, Rui; Marques, Carla; Catarino, Steve; Enguita, Francisco J; Costa, Marina C; Matafome, Paulo; Zuzarte, Mónica; et al. "MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1". Cardiovascular Research 114 1 (2017): 53-64. http://dx.doi.org/10.1093/cvr/cvx187.
    10.1093/cvr/cvx187
  11. Ribeiro-Rodrigues TM; Catarino S; Pinho MJ; Pereira P; Girao H. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive.". (2015): http://europepmc.org/abstract/med/26009193.
    10.1042/BST20150036
  12. Martins-Marques T; Catarino S; Marques C; Pereira P; Girão H. "To beat or not to beat: degradation of Cx43 imposes the heart rhythm.". (2015): http://europepmc.org/abstract/med/26009194.
    10.1042/BST20150046
  13. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
    10.1016/j.biochi.2015.02.020
  14. Martins-Marques T; Catarino S; Zuzarte M; Marques C; Matafome P; Pereira P; Girão H. "Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes.". (2015): http://europepmc.org/abstract/med/25605500.
    10.1042/BJ20141370
  15. Catarino, Steve. "Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.". Scientific Reports (2015): http://europepmc.org/abstract/med/26445927.
    10.1038/srep14888
  16. Soares AR; Martins-Marques T; Ribeiro-Rodrigues T; Ferreira JV; Catarino S; Pinho MJ; Zuzarte M; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.". (2015): http://europepmc.org/abstract/med/26285688.
    10.1038/srep13243
  17. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
    10.1096/fj.13-248963
  18. Catarino, Steve; Bento, Carla F.; Brito, Ana; Murteira, Eliana; Fernandes, Alexandre F.; Pereira, Paulo. "Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells". Acta Ophthalmologica 90 4 (2012): e255-e263. http://dx.doi.org/10.1111/j.1755-3768.2011.02350.x.
    10.1111/j.1755-3768.2011.02350.x
  19. Catarino, S.; Ramalho, J.S.; Marques, C.; Pereira, P.; Girão, H.. "Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal". Biochemical Journal 437 2 (2011): 255-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959687376&partnerID=MN8TOARS.
    10.1042/BJ20102059
  20. Girão, Henrique; Catarino, Steve; Pereira, Paulo. "Eps15 interacts with ubiquitinated Cx43 and mediates its internalization". Experimental Cell Research 315 20 (2009): 3587-3597. http://dx.doi.org/10.1016/j.yexcr.2009.10.003.
    10.1016/j.yexcr.2009.10.003
  21. Girão, Henrique; Catarino, Steve; Pereira, Paulo; Girão, H.; Catarino, S.; Pereira, P.. "7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells.". Cell Communication and Signaling 2 1 (2004): 2. http://dx.doi.org/10.1186/1478-811x-2-2.
    10.1186/1478-811x-2-2
Preprint
  1. Neuza Domingues; Steve Catarino; Beatriz Cristovao; Lisa Rodrigues; Carvalho Filomena; Maria Joao Sarmento; Monica Zuzarte; et al. "Cx43 promotes exocytosis of damaged lysosomes through actin remodelling". 2022. https://doi.org/10.21203/rs.3.rs-2277227/v1.
    10.21203/rs.3.rs-2277227/v1
Thesis / Dissertation
  1. Catarino, Steve Mendes. "Mind the gap : a new molecular model for the intracellular trafficking of connexin 43". PhD, 2010. http://hdl.handle.net/10316/14239.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/30 Connexins, exocytosis and extracellular vesicles IV Metabolism, Ageing and Disease (MAD) Meeting
CIBB (Coimbra, Portugal)
2018/02/17 Cx43 interacts directly with LC3 protein family members through a LIR motif 1st Meeting on Vesicular Biology
(Coimbra, Portugal)
2016/11/02 Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy 3rd PROTEOSTASIS Action Meeting
(Lisbon, Portugal)
2010/12/10 Regulation of intercellular communication by ubiquitin 2nd Annual Meeting of IBILI
(Coimbra, Portugal)
2004/11/17 Degradação dependente do proteossoma da Cx43 em células epiteliais do cristalino requer o terminal carboxílico da proteína IV Congresso de Investigação em Medicina
(Coimbra, Portugal)
2004/09/24 Proteasome-dependent degradation of Cx43 in lens epithelial cells requires the carboxyl-terminal of the protein. EVER-European Association for Vision and Eye Research 2004
(Vilamoura, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015/04/01 - 2016/04/01 Molecular studies of a novel mutation in MYO7A gene in Usher Syndrome type I
Co-supervisor
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2015 Interaction between Cx43 and LC3 directs gap junctions to ubiquitin-independent autophagy degradation
Co-supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal