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Dalila Madeira Nascimento Mil-Homens. Concluiu o(a) Doutoramento em Biotecnologia em 2012/03/23 pelo(a) Universidade de Lisboa Instituto Superior Técnico, Mestrado em Biotecnologia (Engenharia Bioquímica) em 2007/12/27 pelo(a) Universidade de Lisboa Instituto Superior Técnico e Licenciatura em Engenharia Química - Biotecnologia em 1999 pelo(a) Universidade de Lisboa Instituto Superior Técnico. Publicou 16 artigos em revistas especializadas.
Identification

Personal identification

Full name
Dalila Madeira Nascimento Mil-Homens

Citation names

  • Mil-Homens, Dalila

Author identifiers

Ciência ID
4E1A-0F05-7D0E
ORCID iD
0000-0002-9727-3579

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
French Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
2012/03/23
Concluded
 Biotecnologia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Burkholderia cenocepacia pathogenesis: unraveling the virulence functions of trimeric autotransporter adhesins and development of alternative therapies to target this pathogen." (THESIS/DISSERTATION)
 Muito Bom
2007/12/27
Concluded
 Biotecnologia (Engenharia Bioquímica) (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Analysis of DNA repeats in the complete genome sequence of Burkholderia cenocepacia J2315 reveals the presence of novel putative virulence genes" (THESIS/DISSERTATION)
 17
1999
Concluded
 Engenharia Química - Biotecnologia (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Não aplicável" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/11/15 - 2024 Contracted Researcher (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2012/06/01 - 2018/10/30 Postdoc (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/05 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/11/06 - 2015/07/05 Invited Assistant Professor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/09/18 - 2010/02/19 Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2002/03/26 - 2007/07/17 Assistant (University Teacher) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projects

Contract

Designation Funders
2021/01/01 - Current Urease next-generation inhibition therapy
PTDC/MED-QUI/3542/2020
Researcher
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - 2024/02/29 Activating dormant bacteria with phage-derived proteins to enhance antibiotic efficacy
PTDC/BIA-MIC/2312/2020
Researcher
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade do Minho Centro de Engenharia Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/17 - 2023/07/16 Engineering broad-spectrum defensosomes for a bacterial antivirulence therapeutic strategy
EXPL/BTM-MAT/0910/2021
Researcher
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2018/10/01 - 2022/09/30 LactoCan - Exploring the interference between Candida spp. and Lactobacilii to foster the development of non-conventional antifungal therapies
PTDC/BBB-BIO/4519/2014
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Ongoing
2012/02/01 - 2015/01/31 Virulence-associated Trimeric Autotransporter Adhesins from Burkholderia cenocepacia: functional, biophysical and structural characterization
PTDC/BIA-MIC/118386/2010
PhD Student Fellow
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Journal article
  1. Catarina F. Santos; Suzana M. Andrade; Dalila Mil-Homens; M. Fátima Montemor; Marta M. Alves. "Antibacterial Activity of ZnO Nanoparticles in a Staphylococcus-aureus-Infected Galleria mellonella Model Is Tuned by Different Apple-Derived Phytocargos". Journal of Functional Biomaterials (2023): https://doi.org/10.3390/jfb14090463.
    10.3390/jfb14090463
  2. Ricardo Estevens; Dalila Mil-Homens; Arsenio M. Fialho. "In-Silico Analysis Highlights the Existence in Members of Burkholderia cepacia Complex of a New Class of Adhesins Possessing Collagen-like Domains". Microorganisms (2023): https://doi.org/10.3390/microorganisms11051118.
    10.3390/microorganisms11051118
  3. Ferreira, A.; Silva, D.; Almeida, C.; Rodrigues, M.E.; Silva, S.; Castro, J.; Mil-Homens, D.; et al. "Effect of phage vB_EcoM_FJ1 on the reduction of ETEC O9:H9 infection in a neonatal pig cell line". Veterinary research 54 1 (2023): 26-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-85150819711&partnerID=MN8TOARS.
    10.1186/s13567-023-01157-x
  4. João F. Almeida; Matilde Marques; Vanessa Oliveira; Conceição Egas; Dalila Mil-Homens; Romeu Viana; Daniel F. R. Cleary; et al. "Marine Sponge and Octocoral-Associated Bacteria Show Versatile Secondary Metabolite Biosynthesis Potential and Antimicrobial Activities against Human Pathogens". Marine Drugs (2022): https://doi.org/10.3390/md21010034.
    10.3390/md21010034
  5. Luís Borges-Araújo; Marina E. Monteiro; Dalila Mil-Homens; Nuno Bernardes; Maria J. Sarmento; Ana Coutinho; Manuel Prieto; Fábio Fernandes. "Impact of Ca2+-Induced PI(4,5)P2 Clusters on PH-YFP Organization and Protein-Protein Interactions". Biomolecules 12 7 (2022): 912-912. https://doi.org/10.3390/biom12070912.
    10.3390/biom12070912
  6. Sandra Godinho Silva; Patrícia Paula; José Paulo da Silva; Dalila Mil-Homens; Miguel Cacho Teixeira; Arsénio Mendes Fialho; Rodrigo Costa; Tina Keller-Costa. "Insights into the Antimicrobial Activities and Metabolomes of Aquimarina (Flavobacteriaceae, Bacteroidetes) Species from the Rare Marine Biosphere". Marine Drugs 20 7 (2022): 423-423. https://doi.org/10.3390/md20070423.
    10.3390/md20070423
  7. Cátia Bárria; Dalila Mil-Homens; Sandra N. Pinto; Arsénio M. Fialho; Cecília M. Arraiano; Susana Domingues. "RNase R, a New Virulence Determinant of Streptococcus pneumoniae (Co-first author)". Microorganisms 10 2 (2022): 317-317. https://doi.org/10.3390/microorganisms10020317.
    10.3390/microorganisms10020317
  8. Araújo, D.; Mil-Homens, D.; Henriques, M.; Silva, S.. "Anti-EFG1 2'-OMethylRNA oligomer inhibits Candida albicans filamentation and attenuates the candidiasis in Galleria mellonella". Molecular Therapy - Nucleic Acids 27 (2022): 517-523. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121974296&partnerID=MN8TOARS.
    10.1016/j.omtn.2021.12.018
  9. Rocha, J.; Ferreira, C.; Mil-Homens, D.; Busquets, A.; Fialho, A.M.; Henriques, I.; Gomila, M.; Manaia, C.M.. "Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?". BMC Genomics 23 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123476790&partnerID=MN8TOARS.
    10.1186/s12864-021-08279-6
  10. Araújo, D.; Mil-Homens, D.; Rodrigues, M.E.; Henriques, M.; Jørgensen, P.T.; Wengel, J.; Silva, S.. "Antisense locked nucleic acid gapmers to control Candida albicans filamentation". Nanomedicine: Nanotechnology, Biology, and Medicine 39 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117620900&partnerID=MN8TOARS.
    10.1016/j.nano.2021.102469
  11. Araújo, D.; Gaspar, R.; Mil-Homens, D.; Henriques, M.; Silva, B.F.B.; Silva, S.. "Cationic lipid-based formulations for encapsulation and delivery of anti-EFG1 2' OMethylRNA oligomer". Medical Mycology 60 5 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130767552&partnerID=MN8TOARS.
    10.1093/mmy/myac030
  12. Pinto, S.N.; Mil-Homens, D.; Pires, R.F.; Alves, M.M.; Serafim, G.; Martinho, N.; Melo, M.; Fialho, A.M.; Bonifácio, V.D.B.. "Core-shell polycationic polyurea pharmadendrimers: new-generation of sustainable broad-spectrum antibiotics and antifungals (Co-first author)". Biomaterials Science 10 18 (2022): 5197-5207. http://www.scopus.com/inward/record.url?eid=2-s2.0-85135334698&partnerID=MN8TOARS.
    10.1039/d2bm00679k
  13. Alves, M.M.; Batista, C.; Mil-Homens, D.; Grenho, L.; Fernandes, M.H.; Santos, C.F.. "Enhanced antibacterial activity of Rosehip extract-functionalized Mg(OH)2 nanoparticles: An in vitro and in vivo study". Colloids and Surfaces B: Biointerfaces 217 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85133847356&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2022.112643
  14. Mafalda Cavalheiro; Daniela Romão; Rui Santos; Dalila Mil-Homens; Pedro Pais; Catarina Costa; Mónica Galocha; et al. "Role of CgTpo4 in Polyamine and Antimicrobial Peptide Resistance: Determining Virulence in Candida glabrata". International Journal of Molecular Sciences 22 3 (2021): 1376-1376. https://doi.org/10.3390/ijms22031376.
    10.3390/ijms22031376
  15. Mil-Homens, Dalila. "Designing P. aeruginosa synthetic phages with reduced genomes.". Scientific reports (2021): https://europepmc.org/articles/PMC7835345.
    10.1038/s41598-021-81580-2
  16. Dalila Mil-Homens; Maria Martins; José Barbosa; Gabriel Serafim; Maria J. Sarmento; Rita F. Pires; Vitória Rodrigues; Vasco D.B. Bonifácio; Sandra N. Pinto. "Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates: In Vivo Virulence Assessment in Galleria mellonella and Potential Therapeutics by Polycationic Oligoethyleneimine". Antibiotics 10 1 (2021): 56-56. https://doi.org/10.3390/antibiotics10010056.
    10.3390/antibiotics10010056
  17. Pimenta, A.I.; Bernardes, N.; Alves, M.M.; Mil-Homens, D.; Fialho, A.M.. "Burkholderia cenocepacia transcriptome during the early contacts with giant plasma membrane vesicles derived from live bronchial epithelial cells". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102376683&partnerID=MN8TOARS.
    10.1038/s41598-021-85222-5
  18. Pimenta, A.I.; Kilcoyne, M.; Bernardes, N.; Mil-Homens, D.; Joshi, L.; Fialho, A.M.. "Burkholderia cenocepacia BCAM2418-induced antibody inhibits bacterial adhesion, confers protection to infection and enables identification of host glycans as adhesin targets". Cellular Microbiology 23 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85104442126&partnerID=MN8TOARS.
    10.1111/cmi.13340
  19. Mil-Homens, Dalila. "Antagonist biocompatibilities of Zn-based materials functionalized with physiological active metal oxides". Colloids and Surfaces B: Biointerfaces (2020): http://dx.doi.org/10.1016/j.colsurfb.2020.110990.
    10.1016/j.colsurfb.2020.110990
  20. Mil-Homens, Dalila. "Phenotypic characterization of trimeric autotransporter adhesin-defective bcaC mutant of Burkholderia cenocepacia: cross-talk towards the histidine kinase BCAM0218". Microbes and Infection (2020): http://dx.doi.org/10.1016/j.micinf.2020.05.018.
    10.1016/j.micinf.2020.05.018
  21. Mil-Homens, Dalila. "Burkholderia cenocepacia-host cell contact controls the transcription activity of the trimeric autotransporter adhesin BCAM2418 gene.". MicrobiologyOpen (2020): https://doi.org/10.1002/mbo3.998.
    10.1002/mbo3.998
  22. Pais, P.; Vagueiro, S.; Mil-Homens, D.; Pimenta, A.I.; Viana, R.; Okamoto, M.; Chibana, H.; Fialho, A.M.; Teixeira, M.C.. "A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: The transcription factor CgTog1". Virulence 11 1 (2020): 1522-1538. http://www.scopus.com/inward/record.url?eid=2-s2.0-85094817781&partnerID=MN8TOARS.
    10.1080/21505594.2020.1839231
  23. Pinto, S.N.; Dias, S.A.; Cruz, A.F.; Mil-Homens, D.; Fernandes, F.; Valle, J.; Andreu, D.; et al. "The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms". Journal of Antimicrobial Chemotherapy 74 9 (2019): 2617-2625. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072058950&partnerID=MN8TOARS.
    10.1093/jac/dkz223
  24. Oliveira, H.; Mendes, A.; Fraga, A.G.; Ferreira, A.; Pimenta, A.I.; Mil-Homens, D.; Fialho, A.M.; Pedrosa, J.; Azeredo, J.. "K2 capsule depolymerase is highly stable, is refractory to resistance, and protects larvae and mice from Acinetobacter baumannii sepsis". Applied and Environmental Microbiology 85 17 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071352666&partnerID=MN8TOARS.
    10.1128/AEM.00934-19
  25. Cavalheiro, M.; Costa, C.; Silva-Dias, A.; Miranda, I.M.; Wang, C.; Pais, P.; Pinto, S.N.; et al. "A transcriptomics approach to unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata Clinical Isolate". Antimicrobial Agents and Chemotherapy 63 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058922924&partnerID=MN8TOARS.
    10.1128/AAC.00995-18
  26. Mil-Homens, D.; Barahona, S.; Moreira, R.N.; Silva, I.J.; Pinto, S.N.; Fialho, A.M.; Arraiano, C.M.. "Stress response protein BolA influences fitness and promotes Salmonella enterica serovar Typhimurium virulence (Co-first author)". Applied and Environmental Microbiology 84 8 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044855369&partnerID=MN8TOARS.
    10.1128/AEM.02850-17
  27. Mil-Homens, Dalila. "Repair of Iron Centers RIC protein contributes to the virulence of Staphylococcus aureus.". Virulence (2017): http://europepmc.org/abstract/med/29020514.
    10.1080/21505594.2017.1389829
  28. Mil-Homens, Dalila; Pinto, Sandra N.; Matos, Rute G.; Arraiano, Cecilia; Fialho, Arsenio M.. "Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation". Cellular Microbiology 19 4 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397854100003&KeyUID=WOS:000397854100003.
    10.1111/cmi.12677
  29. Santos, R.; Costa, C.; Mil-Homens, D.; Romão, D.; de Carvalho, C.C.C.R.; Pais, P.; Mira, N.P.; et al. "The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata". Cellular Microbiology 19 5 (2017): NIL_7-NIL_19. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007526016&partnerID=MN8TOARS.
    10.1111/cmi.12686
  30. Romão, D.; Cavalheiro, M.; Mil-Homens, D.; Santos, R.; Pais, P.; Costa, C.; Takahashi-Nakaguchi, A.; et al. "A new determinant of Candida glabrata virulence: The acetate exporter CgDtr1". Frontiers in Cellular and Infection Microbiology 7 NOV (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85034862275&partnerID=MN8TOARS.
    10.3389/fcimb.2017.00473
  31. Mil-Homens, D.; Ferreira-Dias, S.; Fialho, A.M.. "Fish oils against Burkholderia and Pseudomonas aeruginosa: In vitro efficacy and their therapeutic and prophylactic effects on infected Galleria mellonella larvae". Journal of Applied Microbiology (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964335017&partnerID=MN8TOARS.
    10.1111/jam.13145
  32. Moreira, Ana S; Mil-Homens, Dalila; Sousa, Silvia A; Coutinho, Carla P; Pinto-de-Oliveira, Ana; Ramos, Christian G; Dos Santos, Sandra C; et al. "Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection.". Virulence (2016): 1-15. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:27652671&KeyUID=MEDLINE:27652671.
    10.1080/21505594.2016.1237334
  33. Mil-Homens, D.; Leç, M.I.; Fernandes, F.; Pinto, S.N.; Fialho, A.M.. "Characterization of BCAM0224, a multifunctional trimeric autotransporter from the human pathogen Burkholderia cenocepacia". Journal of Bacteriology 196 11 (2014): 1968-1979. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899752315&partnerID=MN8TOARS.
    10.1128/JB.00061-14
  34. El-Kirat-Chatel, S.; Mil-Homens, D.; Beaussart, A.; Fialho, A.M.; Dufrêne, Y.F.. "Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin". Molecular Microbiology 89 4 (2013): 649-659. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881545645&partnerID=MN8TOARS.
    10.1111/mmi.12301
  35. Viegas, S.C.; Mil-Homens, D.; Fialho, A.M.; Arraiano, C.M.. "The virulence of salmonella enterica serovar typhimurium in the insect model galleria mellonella is impaired by mutations in RNase E and RNase III (Co-first author)". Applied and Environmental Microbiology 79 19 (2013): 6124-6133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884172994&partnerID=MN8TOARS.
    10.1128/AEM.02044-13
  36. Mil-Homens, D.; Fialho, A.M.. "A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence". PLoS ONE 7 7 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864361810&partnerID=MN8TOARS.
    10.1371/journal.pone.0041747
  37. Mil-Homens, D.; Bernardes, N.; Fialho, A.M.. "The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia". FEMS Microbiology Letters 328 1 (2012): 61-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856461868&partnerID=MN8TOARS.
    10.1111/j.1574-6968.2011.02476.x
  38. Mil-Homens D; Fialho AM. "Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.". (2011): http://europepmc.org/abstract/med/22919579.
    10.3389/fcimb.2011.00013
  39. Rocha, J.; Popescu, A.O.; Borges, P.; Mil-Homens, D.; Moreira, L.M.; Sá-Correia, I.; Fialho, A.M.; Frazão, C.. "Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate". Journal of Bacteriology 193 15 (2011): 3978-3987. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960418213&partnerID=MN8TOARS.
    10.1128/JB.01076-10
  40. Silva, I.N.; Ferreira, A.S.; Becker, J.D.; Zlosnik, J.E.A.; Speert, D.P.; He, J.; Mil-Homens, D.; Moreira, L.M.. "Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence". Microbiology 157 11 (2011): 3124-3137. http://www.scopus.com/inward/record.url?eid=2-s2.0-80155192290&partnerID=MN8TOARS.
    10.1099/mic.0.050989-0
  41. Mil-Homens, D.; Rocha, E.P.C.; Fialho, A.M.. "Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage". Microbiology 156 4 (2010): 1084-1096. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950678687&partnerID=MN8TOARS.
    10.1099/mic.0.032623-0
  42. Holden, M.T.G.; Seth-Smith, H.M.B.; Crossman, L.C.; Sebaihia, M.; Bentley, S.D.; Cerdeño-Tárraga, A.M.; Thomson, N.R.; et al. "Erratum: The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients (Journal Of Bacteriology (2009) 191:1 (261-277))". Journal of Bacteriology 191 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-66249131997&partnerID=MN8TOARS.
    10.1128/JB.00168-09
  43. Holden, M.T.G.; Seth-Smith, H.M.B.; Crossman, L.C.; Sebaihia, M.; Bentley, S.D.; Cerdeño-Tárraga, A.M.; Thomson, N.R.; et al. "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients". Journal of Bacteriology 91 1 (2009): 261-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149507650&partnerID=MN8TOARS.
    10.1128/JB.01230-08

Other

Other output
  1. Increased production of pathogenic, airborne fungal spores upon exposure of a soil mycobiota to chlorinated aromatic hydrocarbon pollutants. 2023. Martins, C.; Piontkivska, D.; Mil-Homens, D.; Guedes, P.; Jorge, J.M.P.; Brinco, J.; Bárria, C.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85150201807&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2543802
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/10/12 Unveiling the role of the trimeric autotransporter adhesin BcaA in Burkholderia cenocepacia host-cells interactions Lisbon Biophysics Networking Meeting
(Lisboa, Portugal)
2018/06/20 Optimization of confocal microscopy imaging techniques to study the diffusioncontrolled action of a cationic antimicrobial peptide along Staphylococcus biofilm 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics
(Castellón, Spain)
2018/05/02 Differential gene expression of Burkholderia cenocepacia Trimeric Autotransporter Adhesin BCAM2418 in the early stages of bacteria-host-cell interactions 21st annual meeting of International Burkholderia cepacia working group (IBCWG)
(Dublin, Ireland)
2018/02/05 Unravelling the antibiofilm activity and mechanism of action of pepR 16th Iberian Peptide Meeting
(Barcelona, Spain)
2017/12/07 Defining the role of Burkholderia cenocepacia trimeric autotransporter BCAM2418 in the early stage of bacteria-host-cell interactions MicroBiotec’17
(Porto, Portugal)
2017/04/22 Optimization of fluorimetric and confocal microscopy techniques to unravel vancomycin activity against Staphylococcus aureus biofilms 27th European Congress of Clinical Microbiology and Infectious Diseases ECCMID
(Viena, Austria)
2015/12/10 Unveiling the role of the trimeric autotransporter adhesin BCAM0224 in Burkholderia cenocepacia pathogenesis MicroBiotec’15
(Évora, Portugal)
2014/04/09 Unraveling the function of BCAM0224 a trimeric autotransporter adhesin from Burkholderia cenocepacia. 18th International annual meeting Burkholderia cepacia Working Group (IBCWG)
(Nimes, France)
2009/11/28 Identification of a novel virulence-associated adhesin cluster unique to epidemic strains of ET-12 lineage of Burkholderia cenocepacia MicroBiotec'09
(Albufeira, Portugal)
2009/04/23 Novel adherence factors of pathogenic Burkholderia cenocepacia: mechanisms of action and their role in virulence. 13th annual meeting of International Burkholderia cepacia Working Group (IBCWG)
(Toronto, Canada)
2009/04/23 Cepacian biosynthesis in the Burkholderia genus: mechanisms and role in virulence 13th annual meeting of International Burkholderia cepacia working group (IBCWG)
(Toronto, Canada)
2009/04/23 Phase variation in Burkholderia multivorans clinical isolates 13th annual meeting of International Burkholderia cepacia working group (IBCWG)
(Toronto, Canada)
2008/03/14 Comparative genomics of Burkholderia species using the MaGe_BurkholScope genome browser 12th annual meeting of International Burkholderia cepacia Working Group (IBCWG)
(Treviso, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09/01 - 2022/11/07 Collagen-like sequences as adhesion factors encoded by the pathogenic bacterium Burkholderia cenocepacia: computational analysis and experimental studies.
Co-supervisor
 Mestrado em Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/01/01 - 2021/01/28 Revestimentos inorgânicos para ligas de magnésio usadas em implantes ortopédicos
Co-supervisor
 Ciências e Engenharia de Materiais (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/01/01 - 2020/12/19 New insights into the interaction of Burkholderia cenocepacia with host cells: Trimeric autotransporter adhesins as pathogenicity factors
Co-supervisor
 Biotecnologia e Biociências (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/09/01 - 2019/12/04 Assessment of antimicrobial activities of marine bacteria against human pathogens
Co-supervisor of Patrícia Lobato Calafate Paula
 Mestrado Bolonha Microbiologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/09/01 - 2018/10/17 Driving microevolution toward azole resistance, independent from PDR1, in Candida glabrata
Co-supervisor
 Microbiologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2016/11/29 Production of outer membrane vesicles by the human pathogen Burkholderia cenocepacia: purification and preliminary characterization
Supervisor
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2015/12/15 Development of new strategies for the purification of Burkholderia cenocepacia outer membrane vesicles (OMVs)
Co-supervisor
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/09/01 - 2014/12/12 Functional characterization of virulence-associated Trimeric Autotransporter Adhesins from the human pathogen Burkholderia cenocepacia
Co-supervisor
 Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/12/05 - 2023/12/07 Experimental Design and Analysis of Data from Animal Experiments | 6th Edition. The course covered the following topics: - Planning for reproducibility in animal research - Common mistakes in design and execution of experiments - Formulating objectives and testing hypotheses - Avoidance of bias (randomization, blind assessment, adequate controls) - Formal experimental designs - Independent replication and appropriate experimental units - Estimating an adequate sample size - Basic concepts in probability and statistics
Other
 Experimental Design and Analysis of Data from Animal Experiments | 6th Edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/05/31 - 2023/06/02 O Workshop de Histologia aplicada à Biomedicina carateriza-se por uma abordagem de treino prático com contextualização teórica, sobre diversas técnicas (colorações histológicas e imunohistoquímicas) para o processamento de tecidos, desde a sua recolha até a sua análise por Microscopia Óptica, incluindo de fluorescência.
Workshop
 Workshop de Histologia aplicada à Biomedicina
Universidade de Aveiro Associação para a Formação Profissional e Investigação, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/11/25 Identification of genetic determinants involved in multicellular aggregation in Burkholderia multivorans.
(Thesis) Main arguer
 Catarina Reis Fernandes Cabeções (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/12/13 Screening of Lactic Acid Bacteria strains for biopharmaceutical-grade plasmid and recombinant protein production
(Thesis) Main arguer
 Stefany Dias Sancho (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/10/15 Biofilm formation in Candida glabrata: the role of the Transcription Factor Tec1
(Thesis) Main arguer
 Diana Gomes Pereira (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/01/26 Avaliação do processo de imunização de murganhos vacinados com virus-like particles (VLPs) contendo candidatos antigénicos de Trypanosoma cruzi
(Thesis) Main arguer
 Yulia Aleksandrovna Yanshina (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015/12/04 Mucoid morphotype variation in Burkholderia multivorans: Role of a Two-Component Regulatory System and a LysR Regulator
(Thesis) Main arguer
 Ana Rita Martins Guerreiro (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/05/18 Estabelecimento do modelo murino para a modulação de toxicidade do Benzonidazol durante a terapêutica da Doença de Chagas (Trypanosoma cruzi)
(Thesis) Main arguer
 Cláudia Jassica Gonçalves Moreno (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/09/01 - 2022/02/28 Engenharia Genética Licenciatura em Engenharia Biomédica, Licenciatura em Engenharia Biológica (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09/01 - 2021/12/20 Biotecnologia Molecular Mestrado em Biotecnologia, Mestrado em Microbiologia, Mestrado Bolonha em Ciências e Tecnologias Para o Património Cultural, Mestrado Bolonha em Proteção e Segurança Radiológica (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09/01 - 2021/07/01 Bioquímica e Biologia Molecular Mestrado integrado em Engenharia Biológica, Mestrado integrado em Engenharia Biomédica, Mestrado integrado em Engenharia Ambiente, Mestrado integrado em Engenharia Química, Mestrado integrado em Engenharia Materiais (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/09/01 - 2015/07/01 Bioquímica e Biologia Molecular Mestrado integrado Engenharia Biológica, Mestrado integrado Engenharia Biomédica, Mestrado integrado Engenharia Química, Mestrado integrado Engenharia Materiais (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/09/01 - 2010/07/09 Microbiologia Industrial Licenciatura em Microbiologia Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2002/09/01 - 2007/07/06 Microbiologia Industrial e Processos Fermentativos Licenciatura em Microbiologia, Licenciatura em Engenharia de Produção Biológica (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2006/09/01 - 2007/07/04 Operações de Processamento Alimentar II Licenciatura em Engenharia de Produção Biológica (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal