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PT - Raquel Laginha é licenciada em Química e mestre em Química Avançada e Industrial na variante Química-Física Experimental e Teórica pela Universidade de Coimbra. Dedica a sua atividade de investigação no estudo experimental (espectroscopia vibracional) de compostos de platina e paládio com potencial atividade anticancerígena. EN - Raquel Laginha has a Bachelor’s degree in Chemistry and a Master's degree in Advanced and Industrial Chemistry variant Experimental and Theoretical Physical Chemistry by the University of Coimbra. Dedicating her research activity to the experimental study (vibrational spectroscopy) of platinum and palladium compounds with potential anticancer activity.
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Identification

Personal identification

Full name
Raquel Cadete Laginha da Silva

Citation names

  • Laginha, Raquel C.
  • Laginha, R.C.
  • R.C., Laginha

Author identifiers

Ciência ID
4F11-809E-F766
ORCID iD
0000-0002-2188-4015
Google Scholar ID
https://scholar.google.com/citations?user=fG2MMXIAAAAJ&hl=pt-PT
Scopus Author Id
58100313100

Email addresses

  • rcl@uc.pt (Professional)

Telephones

Mobile phone
  • (351) 912046061 (Personal)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Physical Chemistry
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2)
Italian Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2) Elementary (A2)
Education
Degree Classification
2024/01 - 2024/01
Concluded
 Tutorial on Visual Analytics for Survival Analysis (Outros)
Univerza v Ljubljani, Slovenia
2021/09 - 2023/09/29
Concluded
 Mestrado em Química (Mestrado)
Major in Química Avançada e Industrial
Universidade de Coimbra Departamento de Química, Portugal
"New Drugs to Fight Osteosarcoma – A Complete Vibrational Microspectroscopy Study" (THESIS/DISSERTATION)
2022/11/01 - 2022/11/03
Concluded
 InfraRed Analysis Training – QUASAR (Outros)
Diamond Light Source Ltd, United Kingdom
2022/08 - 2022/10
Concluded
 MATLAB Fundamentals (Outros)
Mathworks Inc, United States
2022/08 - 2022/08
Concluded
 MATLAB Onramp (Outros)
Mathworks Inc, United States
2018/09 - 2021/07
Concluded
 Licenciatura em Química (Licenciatura)
Universidade de Coimbra Departamento de Química, Portugal
2021/04/12 - 2021/04/13
Concluded
 OriginPro (Outros)
Universidade de Coimbra Departamento de Química, Portugal
Affiliation

Science

Category
Host institution 		Employer
2021/02 - Current Research Trainee (Research) Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal
2021/09 - 2022/02 Research Trainee (Research) Instituto Politécnico de Viseu Escola Superior Agrária de Viseu, Portugal
Outputs

Publications

Conference poster
  1. Laginha, Raquel C.; Silva, J.D.; Cinque, G.; Batista de Carvalho, L. A. E.; A.L.M., Batista de Carvalho. "Uncovering New Chemotherapeutic Methods for Osteosarcoma with Vibrational Microspectroscopy". Paper presented in 20th European Conference on the Spectroscopy of Biological Molecules (ECSBM20)., 2024.
  2. Silva, Jéssica D.; MARQUES, JOANA; P. Santos, Inês; Ana L. M. Batista de Carvalho; Martins, Clara B.; Laginha, Raquel C.; Luís A. E. Batista de Carvalho; Maria Paula M. Marques. "Biochemical Impact of a Non-Conventional Platinum Agent Against Lung Cancer - A Vibrational Microspectroscopy Study". Paper presented in 15th National Physical Chemistry Meeting, 2023.
  3. Laginha, Raquel C.; P. Santos, Inês; Ana L. M. Batista de Carvalho. "Chemotherapeutic response to cisplatin and Pd2 -Spm drugs in PC-3 cell line by FTIR microspectroscopy". Paper presented in VIII Encontro Nacional de Estudantes de Química, 2022.
Journal article
  1. Laginha, Raquel C.; Silva, J.D.; Gianfelice Cinque; Luís A. E. Batista de Carvalho; A.L.M., Batista de Carvalho. "Vibrational Microspectroscopy as a Tool to Unveil New Chemotherapeutic Strategies against Osteosarcoma". Spectrochimica Acta Part A (2024):
    Under revision
  2. Carneiro, Tatiana J.; Batista de Carvalho, Ana L. M.; Vojtek, Martin; Laginha, Raquel C.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer". Journal of Medicinal Chemistry (2024):
    Published
  3. Jéssica Domingues Silva; Joana Marques; Inês P. Santos; Ana Batista de Carvalho; Clara B. Martins; Raquel Laginha; Luis A. E. Batista de Carvalho; MPM Marques. "A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line". Molecules (2023): https://www.mdpi.com/1420-3049/28/4/1698.
    10.3390/molecules28041698
  4. Laginha, Raquel C.; Martins, Clara B.; Brandão, Ana L. C.; Marques, Joana; Marques, M. Paula M.; Batista de Carvalho, Luís A. E.; Santos, Inês P.; Batista de Carvalho, Ana L. M.. "Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies". International Journal of Molecular Sciences 24 3 (2023): 1888. http://dx.doi.org/10.3390/ijms24031888.
    10.3390/ijms24031888
Thesis / Dissertation
  1. "New Drugs to Fight Osteosarcoma - A Complete Vibrational Microspectroscopy Study". Master, Universidade de Coimbra, 2023.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/09 Shining Insight: Probing Lung Cancer Cells with a Non-Conventional Platinum Complex BIOPHYSICS FESTIVAL – 4 th Meeting of Young Biophysicists
Faculty of Sciences of University of Beira Interior (Portugal)
2023/10/26 New Strategies to Fight Cancer - The Role of Neutrons The Simulation Meets Molecular Spectroscopy (SiMol) Meeting
2023/10/11 Advantages of FTIR Microspectroscopy with Synchrotron Radiation - an Inside View into Osteosarcoma Treatments - Large-Scale Facilities European Large-Scale Facilities and the Research Infrastructures: Opportunities and How to Apply
CICECO - Aveiro Institute of Materials (Aveiro, Portugal)
2023/08/27 Thriving Advantages of Drug Combination in Osteosarcoma Treatment - A Vibrational Microspectroscopy Study International Conference on Advanced Vibrational Spectroscopy (ICAVS12)
(Krakow, Poland)
2023/06/21 Advantages of FTIR Microspectroscopy with Synchrotron Radiation - an Inside View into Osteosarcoma Treatment Encontro Nacional De Utilizadores De Radiação De Sincrotrão (ENURS 2023)
Politécnico de Leiria (Marinha Grande, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/04/23 - 2024/04/23 A Floresta Portuguesa num Mundo em Mudança (2024/04/23 - 2024/04/23)
Congress (Member of the Scientific Committee)
 Universidade de Coimbra, Portugal
2022/04/08 - 2022/04/10 VIII Encontro Nacional de Estudantes de Química (2022/04/08 - 2022/04/10)
Conference (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2022/02/22 - 2022/02/23 IX Feira de Emprego e Empreendedorismo (2022/02/22 - 2022/02/23)
Congress (Member of the Scientific Committee)
 Universidade de Coimbra Departamento de Química, Portugal
2021/11/11 - 2021/11/13 VII Encontro Científico (2021/11/11 - 2021/11/13)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Departamento de Química, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/02/20 - 2023/02/20 ExPaNDS is the European Open Science Cloud (EOSC) Photon and Neutron Data Service
Seminar
 ExPaNDS
Diamond Light Source Ltd, United Kingdom
2023/01/20 - 2023/01/20 Neutron and Muons: from Science to Society
Workshop
 Neutron and Muons: from Science to Society

Association member

Society Organization name Role
2023/07 - Current BIOGLEBA - ASSOCIAÇÃO JUVENIL Membro da Direção
2020/09 - 2022/04 Núcleo de Estudantes de Química da Associação Académica de Coimbra Membro da Direção

Mentoring / Tutoring

Topic Student name
2024/04/17 - 2024/04/17 Espetroscopia Molecular - Aplicações da Espectroscopia Vibracional Students of the Degree in Biochemistry
2024/03/18 - 2024/04/08 Desenvolvimento de Fármacos II - Espectroscopia Vibracional Aplicada à Química Medicinal Students of the Degree in Medicinal Chemistry
2023/10/16 - 2023/11/29 Laboratórios de Química Geral Students of the Degree in Physics Engineering
2023/07 - 2023/09 Avaliação da citotoxicidade de complexos metálicos de Pd(II) e Pt(II) em linha celular de cancro de Colon Sabrina Louise Lopes Pereira
2023/07 - 2023/07 Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de colon por microespectroscopia de Raman Mariana Isabel Breia Silva
2023/06 - 2023/06 Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de Colon por microespectroscopia de Infravermelho João Fernando de Sousa Henriques
2023/02 - 2023/06 Desenvolvimento de Novos Agentes Anticancerígenos com Pd(II) Contra o Cancro do Cólon –Estudo por Microespetroscopia Vibracional Bruna Queiroz de Brito
2023/04/27 - 2023/04/27 Desenvolvimento de Fármacos - Quasar Spectroscopy: uma ferramenta de análise de dados Students of the Degree in Medicinal Chemistry
2022 - 2023 Tutorial em Química Bruna Rocha Costa
2022 - 2023 Tutorial em Química Daniel Lagoa Madeira
2022 - 2023 Tutorial em Química Teresa Branco Torres da Costa
2022/10/12 - 2022/12/14 Laboratórios de Química Geral Students of the Degree in Biomedical Engineering
2022/07 - 2022/09 Novos métodos de diagnóstico de rejeição hepática pós transplantação - espectroscopia vibracional Catarina Alcobia Montargil

Scientific expedition

Activity description Institution / Organization
2024/09 - 2024/09 Probing Metallodrug Action on Human Cancer Cells by QSM ISIS@MACH ITALIA, Italy
2024/01/23 - 2024/01/29 Experiment SM34385: Probing Metallodrug Action at the Single Cell Level - SR-FTIR Imaging via FPA on Human Breast Cancer Cells Diamond Light Source Ltd, United Kingdom
2023/12/11 - 2023/12/15 Experiment SM34458: THz Spectroscopy - an Unmet Approach to Study DNA Interaction in Osteosarcoma Treatment: Pt(II) and Pd(II) Complexes Application According to the EURAMOS-1 Protocol Diamond Light Source Ltd, United Kingdom
2023/04/20 - 2023/04/24 Experiment SM32861: Thriving Advantages of Drug Combination in Osteosarcoma Treatment: Pt(II) and Pd(II) Complexes Application According to the EURAMOS-1 Protocol Diamond Light Source Ltd, United Kingdom
Distinctions

Other distinction

2018 Membro do Quadro de Honra
Colégio Rainha D. Leonor, Portugal
2015 Membro do Quadro de Honra
Colégio Rainha D. Leonor, Portugal