???global.info.a_carregar???
Michael González-Durruthy é graduado em Ciências Farmacêuticas (2002-2007), posui mestrado em Toxicologia Experimental (2008-2011); ambos pela Universidad de La Habana (UH/Cuba). Foi professor (instrutor) de Toxicologia do Departamento de Farmacologia e Toxicologia da Faculdade de Ciências Farmacêuticas (2007-2014). Doutor em Ciências Fisiológicas pela Universidade Federal do Rio Grande-FURG (2014-2018) trabalhando nos domínios científicos de Ciências Exatas (área: Química, sub-área: Quimica Medicinal) e Ciências Médicas e da Saúde (área: Farmacologia e Toxicologia, sub-área: Bioinformática) impactando com ênfase em Bioquímica e Nanotoxicologia Computacional, Metabolismo e Fisiologia Mitocondrial, e Farmacologia e Toxicologia Mitocondrial, orientado a estudos toxicologicos in silico de nanomateriais de carbono baseados em docking molecular, virtual screening, relações quantitativas estrutura-atividade acoplados a aprendizado automático (QSAR-machine learning) e redes neurais artificiais (ANN) na descoberta de novos alvos terapéuticos (mitocôndria) contra o cancro e outras doenças degenerativas com impacto em nanomedicina de precisão. Publicou 34 artigos em revistas especializadas e revisadas por pares. Atualmente, participa como investigador colabrador no Biosystems & Integrative Sciences Institute da Faculdade de Ciências Universidade de Lisboa-Portugal, (BioISI-FCUL) no Departamento de Físico-Química (2019-present). Também é investigador associado Laboratório Associado para a Química Verde Tecnologias e Processos Limpos do Departamento de Quìmica e Bioquìmica Faculdade de Ciências da Universidade do Porto-Portugal (LAQV@REQUINTE, DQB-FCUP); atuando na área de Química Medicinal e Bioquímica Computacional (2019-present). Realizou Pós-doutoramento em Nanotoxicologia Computacional no DQB-FCUP (2018-2019) visando "avalição de riscos de nanomateriais carbono com poteciais aplicações biomedicas em para nanomedicina de precisão". No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Nanotoxicologia Computational e Nanomedicina Mitocondrial.
Read full resume ↓
Identification

Personal identification

Full name
Michael González-Durruthy
Date of birth
1983/08/09
Gender
Male

Citation names

  • González-Durruthy, Michael

Author identifiers

Ciência ID
4F12-B941-0825
ORCID iD
0000-0002-7061-0811

Email addresses

  • gonzalezdurruthy.furg@gmail.com (Professional)

Telephones

Mobile phone
  • 920276152 (Personal)

Addresses

  • Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal, 4169-007, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
English Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Portuguese Elementary (A2) Beginner (A1) Beginner (A1) Beginner (A1) Elementary (A2)
Galician Elementary (A2) Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2)
Education
Degree Classification
2014/03/01 - 2018/02/21
Concluded
 Ciencias Fisiológicas (Doctor)
Major in Fisiologia, metabolismo e Bioquímica Mitocondrial
Universidade Federal do Rio Grande, Brazil
"EFEITOS DE NANOTUBOS DE CARBONO BASEADOS EM MECANISMOS MITOCONDRIAIS E CORRELAÇÕES IN SILICO ESTRUTURA-ATIVIDADE" (THESIS/DISSERTATION)
 20
2007/09/01 - 2009/07/15
Concluded
 Toxicologia Experimental (Master)
Major in Toxicologia
Universidad de la Habana, Cuba
"The influence of size of silver nanoparticles in the oral acute toxicity of Sprague Dawley rats" (THESIS/DISSERTATION)
 19
2002/09/01 - 2007/07/15
Concluded
 Ciências Farmacêuticas (Licence)
Universidad Agraria de la Habana, Cuba
"Toxicology and safety of the 4-hidroxi-3-metoxibenzaldehido: Acute, subchronic and reproductive toxicity studies" (THESIS/DISSERTATION)
 19
Affiliation

Science

Category
Host institution 		Employer
2019/07/15 - Current Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
(...)
2018/05/11 - Current Visiting Researcher (Research) Universidad del País Vasco, Spain
Universidad del País Vasco - Campus Bizkaia, Spain
2018/04/11 - Current Visiting Researcher (Research) Universidade de Santiago de Compostela, Spain
Universidade de Santiago de Compostela Facultade de Física, Spain
2019/07/15 - 2020/10/15 Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2018/04/11 - 2019/04/11 Postdoc (Research) Universidade do Porto, Portugal
Universidade do Porto, Portugal
2018/02/21 - 2018/04/01 Postdoc (Research) Universidade Federal do Rio Grande, Brazil
Universidade Federal do Rio Grande, Brazil

Teaching in Higher Education

Category
Host institution 		Employer
2007/09/01 - 2014/02/15 Assistant Professor (University Teacher) Universidad de la Habana Facultad de Farmacia y Alimentos, Cuba
Universidad de la Habana, Cuba
Projects

Grant

Designation Funders
2018/04/11 - 2019/04/11 INTERREG NanoDESK SUDOE
SOE1/P1/E0215
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2016/01/28 - 2017/02/28 NANoREG project A common European approach to the regulatory testing of nanomaterials
FURG
PhD Student Fellow
Concluded

Contract

Designation Funders
2019/07/12 - Current projeto iDrugCF Identification of New Drugs for Cystic Fibrosis
PTDC/MED-QUI/28800/2017
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/06/26 - 2018/01/01 Estratégias para avaliar toxicidade de nanomateriais de carbono Utilização do nematoide Caenorhabditis elegans e implementação de técnicas de nanotoxicologia computacional
14944.317.15748.22052014
PhD Student Fellow
Concluded

Other

Designation Funders
2017/06/26 - 2018/12/01 Mineração de Dados Aplicada em Resultados de Docagem Molecular, Triagem Virtual e Dinâmica Molecular
27740.414.17766.26062017
PhD Student Fellow
Concluded
2018/01/19 - 2018/02/28 Nanopartículas Lipídicas Sólidas com Curcumina e Capsaicina Um Potencial Tratamento para Doença Inflamatória Intestinal
EDITAL FAPERGS 05/2019
Post-doc
Concluded
Outputs

Publications

Conference paper
  1. González-Durruthy, Michael. "Combining Single-Walled Carbon Nanocones with Antioxidant Vitamins C and E". Paper presented in MOL2NET MDPI Sciforum NANOMATJND-02: JSU-NDSU Nanotech. & Materials Science Workshop, Bilbao, 2020.
    Published
  2. González-Durruthy, Michael. "Nanostructured scaffolds for bone regeneration Microfluidic device". Paper presented in VIII Iberian Meeting on Colloids and Interfaces, Aveiro, 2019.
  3. González-Durruthy, Michael. "Modelación in Silico de Biocatalizadores Inmovilizados Enzimas y Células. Posibles Aplicaciones Productivas". Paper presented in V Simposium BIOCATEM, 2018.
Journal article
  1. Ramón Rial; Michael González-Durruthy; Zhen Liu; Juan M. Ruso. "Advanced Materials Based on Nanosized Hydroxyapatite". Molecules (2021): https://www.mdpi.com/1420-3049/26/11/3190.
    10.3390/molecules26113190
  2. Patricia Ferreira Schopf; Ivana Zanella; M. Natália D. S. Cordeiro; Juan M. Ruso; Michael González-Durruthy; Mirkos Martins. "Nanomarker for Early Detection of Alzheimer’s Disease Combining Ab initio DFT Simulations and Molecular Docking Approach". Biophysica (2021): https://www.mdpi.com/2673-4125/1/2/7.
    10.3390/biophysica1020007
  3. Michael González-Durruthy; Riccardo Concu; Juan M. Ruso; M. Natália D. S. Cordeiro. "New Mechanistic Insights on Carbon Nanotubes’ Nanotoxicity Using Isolated Submitochondrial Particles, Molecular Docking, and Nano-QSTR Approaches". Biology (2021): https://www.mdpi.com/2079-7737/10/3/171.
    10.3390/biology10030171
  4. González-Durruthy, Michael; Concu, Riccardo; Vendrame, Laura F. Osmari; Zanella, Ivana; Ruso, Juan M.; Cordeiro, M. Natália D. S.. "Targeting Beta-Blocker Drug–Drug Interactions with Fibrinogen Blood Plasma Protein: A Computational and Experimental Study". Molecules 25 22 (2020): 5425. http://dx.doi.org/10.3390/molecules25225425.
    10.3390/molecules25225425
  5. de Oliveira, Patrícia Viera; Goulart, Luiza; dos Santos, Cláudia Lange; Rossato, Jussane; Fagan, Solange Binotto; Zanella, Ivana; Cordeiro, M. Natália D.S.; Ruso, Juan M.; González-Durruthy, Michael. "Computational Modeling of Environmental Co-exposure on Oil-Derived Hydrocarbon Overload by Using Substrate-Specific Transport Protein (TodX) with Graphene Nanostructures". Current Topics in Medicinal Chemistry 20 25 (2020): 2308-2325. http://dx.doi.org/10.2174/1568026620666200820145412.
    10.2174/1568026620666200820145412
  6. González-Durruthy, Michael; Scanavachi, Gustavo; Rial, Ramón; Liu, Zhen; Cordeiro, M. Natália D.S.; Itri, Rosangela; Ruso, Juan M.. "Mapping the underlying mechanisms of fibrinogen benzothiazole drug interactions using computational and experimental approaches". International Journal of Biological Macromolecules 163 (2020): 730-744. http://dx.doi.org/10.1016/j.ijbiomac.2020.07.044.
    10.1016/j.ijbiomac.2020.07.044
  7. González-Durruthy, Michael; Rial, Ramón; Cordeiro, M. Natália D.S.; Liu, Zhen; Ruso, Juan M.. "Exploring the conformational binding mechanism of fibrinogen induced by interactions with penicillin ß-lactam antibiotic drugs". Journal of Molecular Liquids (2020): 114667. http://dx.doi.org/10.1016/j.molliq.2020.114667.
    10.1016/j.molliq.2020.114667
  8. González-Durruthy, Michael; Giri, Amal Kanta; Moreira, Irina; Concu, Riccardo; Melo, André; Ruso, Juan M.; Cordeiro, M. Natália D.S.. "Computational modeling on mitochondrial channel nanotoxicity". Nano Today 34 (2020): 100913. http://dx.doi.org/10.1016/j.nantod.2020.100913.
    Published • 10.1016/j.nantod.2020.100913
  9. Concu, Riccardo; González-Durruthy, Michael; Cordeiro, M. Natália D. S.. "Developing a Multi-target Model to Predict the Activity of Monoamine Oxidase A and B Drugs". Current Topics in Medicinal Chemistry 20 (2020): http://dx.doi.org/10.2174/1568026620666200603121224.
    10.2174/1568026620666200603121224
  10. Josende, Marcelo Estrella; Nunes, Silvana Manske; de Oliveira Lobato, Roberta; González-Durruthy, Michael; Kist, Luiza Wilges; Bogo, Maurício Reis; Wasielesky, Wilson; et al. "Graphene oxide and GST-omega enzyme: An interaction that affects arsenic metabolism in the shrimp Litopenaeus vannamei". Science of The Total Environment 716 (2020): 136893. http://dx.doi.org/10.1016/j.scitotenv.2020.136893.
    10.1016/j.scitotenv.2020.136893
  11. Pardo Andreu, G.L.; Reis, F.Z.D.; González-Durruthy, M.; Hernández, R.D.; D'Vries, R.F.; Vanden Berghe, W.; Alberici, L.C.. "Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death". Toxicology in Vitro 63 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075312696&partnerID=MN8TOARS.
    10.1016/j.tiv.2019.104737
  12. González-Durruthy, Michael. "In vitro and in silico protein corona formation evaluation of curcumin and capsaicin loaded-solid lipid nanoparticles". Toxicology in Vitro (2019): http://dx.doi.org/10.1016/j.tiv.2019.104598.
    10.1016/j.tiv.2019.104598
  13. Tonel, M.Z.; González-Durruthy, M.; Zanella, I.; Fagan, S.B.. "Interactions of graphene derivatives with glutamate-neurotransmitter: A parallel first principles - Docking investigation". Journal of Molecular Graphics and Modelling 88 (2019): 121-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060517677&partnerID=MN8TOARS.
    10.1016/j.jmgm.2019.01.007
  14. González-Durruthy, M.; Monserrat, J.M.; Viera De Oliveira, P.; Fagan, S.B.; Werhli, A.V.; Machado, K.; Melo, A.; et al. "Computational MitoTarget Scanning Based on Topological Vacancies of Single-Walled Carbon Nanotubes with the Human Mitochondrial Voltage-Dependent Anion Channel (hVDAC1)". Chemical Research in Toxicology 32 4 (2019): 566-577. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064445169&partnerID=MN8TOARS.
    10.1021/acs.chemrestox.8b00266
  15. Marques, M.B.; de Oliveira, P.V.; Fagan, S.B.; Oliveira, B.R.; da Silva Nornberg, B.F.; Almeida, D.V.; Marins, L.F.; González-Durruthy, M.. "Modeling drug-drug interactions of AZD1208 with Vincristine and Daunorubicin on ligand-extrusion binding TMD-domains of multidrug resistance P-glycoprotein (ABCB1)". Toxicology 411 (2019): 81-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056604657&partnerID=MN8TOARS.
    10.1016/j.tox.2018.10.009
  16. González-Durruthy, M.; Manske Nunes, S.; Ventura-Lima, J.; Gelesky, M.A.; González-Díaz, H.; Monserrat, J.M.; Concu, R.; Cordeiro, M.N.D.S.. "MitoTarget Modeling Using ANN-Classification Models Based on Fractal SEM Nano-Descriptors: Carbon Nanotubes as Mitochondrial F0F1-ATPase Inhibitors". Journal of Chemical Information and Modeling 59 1 (2019): 86-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058096852&partnerID=MN8TOARS.
    10.1021/acs.jcim.8b00631
  17. Marques, M.B.; González-Durruthy, M.; Nornberg, B.F.S.; Oliveira, B.R.; Almeida, D.V.; Votto, A.P.S.; Marins, L.F.. "New mechanistic insight on the PIM-1 kinase inhibitor AZD1208 using multidrug resistant human erythroleukemia cell lines and molecular docking simulations". Current Topics in Medicinal Chemistry 19 11 (2019): 914-926. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071032920&partnerID=MN8TOARS.
    10.2174/1568026619666190509121606
  18. González-Durruthy, M.; Scanavachi, G.; Rial, R.; Liu, Z.; Cordeiro, M.N.D.S.; Itri, R.; Ruso, J.M.. "Structural and energetic evolution of fibrinogen toward to the betablocker interactions". International Journal of Biological Macromolecules 137 (2019): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068354894&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2019.06.229
  19. González-Durruthy, Michael. "Cytoprotection of lipoic acid against toxicity induced by saxitoxin in hippocampal cell line HT-22 through in silico modeling and in vitro assays". Toxicology (2018): http://dx.doi.org/10.1016/j.tox.2017.11.004.
    10.1016/j.tox.2017.11.004
  20. Manske Nunes, S.; Josende, M.E.; González-Durruthy, M.; Pires Ruas, C.; Gelesky, M.A.; Romano, L.A.; Fattorini, D.; et al. "Different crystalline forms of titanium dioxide nanomaterial (rutile and anatase) can influence the toxicity of copper in golden mussel Limnoperna fortunei?". Aquatic Toxicology 205 (2018): 182-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055910470&partnerID=MN8TOARS.
    10.1016/j.aquatox.2018.10.009
  21. González-Durruthy, Michael. "Carbon Nanotubes’ Effect on Mitochondrial Oxygen Flux Dynamics: Polarography Experimental Study and Machine Learning Models using Star Graph Trace Invariants of Raman Spectra". Nanomaterials (2017): http://www.mdpi.com/2079-4991/7/11/386.
    10.3390/nano7110386
  22. González-Durruthy, Michael. "Interaction of single-walled carbon nanotubes and saxitoxin: Ab initio simulations and biological responses in hippocampal cell line HT-22". Environmental Toxicology and Chemistry (2017): http://dx.doi.org/10.1002/etc.3544.
    10.1002/etc.3544
  23. González-Durruthy, M.; Werhli, A.V.; Seus, V.; Machado, K.S.; Pazos, A.; Munteanu, C.R.; González-Díaz, H.; Monserrat, J.M.. "Decrypting Strong and Weak Single-Walled Carbon Nanotubes Interactions with Mitochondrial Voltage-Dependent Anion Channels Using Molecular Docking and Perturbation Theory". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85031774542&partnerID=MN8TOARS.
    10.1038/s41598-017-13691-8
  24. González-Durruthy, M.; Castro, M.; Nunes, S.M.; Ventura-Lima, J.; Alberici, L.C.; Naal, Z.; Atique-Sawazaki, D.T.; et al. "QSPR/QSAR-based Perturbation Theory approach and mechanistic electrochemical assays on carbon nanotubes with optimal properties against mitochondrial Fenton reaction experimentally induced by Fe2+-overload". Carbon 115 (2017): 312-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009230722&partnerID=MN8TOARS.
    10.1016/j.carbon.2017.01.002
  25. González-Durruthy, M.; Alberici, L.C.; Curti, C.; Naal, Z.; Atique-Sawazaki, D.T.; Vázquez-Naya, J.M.; González-Díaz, H.; Munteanu, C.R.. "Experimental-Computational Study of Carbon Nanotube Effects on Mitochondrial Respiration: In Silico Nano-QSPR Machine Learning Models Based on New Raman Spectra Transform with Markov-Shannon Entropy Invariants". Journal of Chemical Information and Modeling 57 5 (2017): 1029-1044. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020443432&partnerID=MN8TOARS.
    10.1021/acs.jcim.6b00458
  26. González-Durruthy, M.; Werhli, A.V.; Cornetet, L.; Machado, K.S.; González-Díaz, H.; Wasiliesky, W.; Ruas, C.P.; Gelesky, M.A.; Monserrat, J.M.. "Predicting the binding properties of single walled carbon nanotubes (SWCNT) with an ADP/ATP mitochondrial carrier using molecular docking, chemoinformatics, and nano-QSBR perturbation theory". RSC Advances 6 63 (2016): 58680-58693. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976427840&partnerID=MN8TOARS.
    10.1039/c6ra08883j
  27. González-Durruthy, M.; Monserrat, J.M.; Alberici, L.C.; Naal, Z.; Curti, C.; González-Díaz, H.. "Mitoprotective activity of oxidized carbon nanotubes against mitochondrial swelling induced in multiple experimental conditions and predictions with new expected-value perturbation theory". RSC Advances 5 125 (2015): 103229-103245. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950109957&partnerID=MN8TOARS.
    10.1039/c5ra14435c
  28. Nuñez-Figueredo, Y.; Ramírez-Sánchez, J.; Delgado-Hernández, R.; Porto-Verdecia, M.; Ochoa-Rodríguez, E.; Verdecia-Reyes, Y.; Marin-Prida, J.; et al. "JM-20, a novel benzodiazepine-dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro". European Journal of Pharmacology 726 1 (2014): 57-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893430992&partnerID=MN8TOARS.
    10.1016/j.ejphar.2014.01.021
  29. González-Durruthy, Michael. "Toxicology and safety of the 4-hidroxi-3-metoxibenzaldehido: Acute, subchronic and reproductive toxicity studies". Toxicology Letters (2010): http://dx.doi.org/10.1016/j.toxlet.2010.03.836.
    10.1016/j.toxlet.2010.03.836
Newspaper article
  1. González-Durruthy, Michael; Riccardo Concu; Juan M. Ruso; M. Natália D.S. Cordeiro. "New Mechanistic Insights on Carbon Nanotubes Nanotoxicity Using Isolated Submitochondrial Particles, Molecular Docking, and Nano-QSTR Approaches", 2021
  2. González-Durruthy, Michael. "Modeling and experimental validation of covalent immobilization of Trametes maxima laccase on glyoxyl and MANA-Sepharose CL 4B supports, for the use in bioconversion of residual colorants", 2021
  3. González-Durruthy, Michael. "Theoretical study on binding interactions of laccase-enzyme from Ganoderma weberianum with multiples ligand substrates with environmental impact", 2019, https://www.heighpubs.org/hpbr/.
  4. González-Durruthy, Michael. "An In Silico DFT-Approach Towards Carbon Nanotubes Applications as Mito Targeted-Nanoparticles on Neurodegenerative Diseases", 2018
Report
  1. González-Durruthy, Michael. 2017. CNT Mitoprotective activity in mitochondrial swelling. http://dx.doi.org/10.3390/mol2net-03-04607.
    10.3390/mol2net-03-04607
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/09/27 Computational modeling on mitochondrial channel nanotoxicity Chemicat-2021 - A Hybrid (Virtual and In-person) Conference on (Chemical Engineering & Catalysis)
Scientia Meetings (Washington D.C., United States)
2021/06/23 Theoretical Insights on Carbon Nanotubes Nanotoxicity Using Isolated Submitochondrial Particles, Molecular Docking, and Nano-QSTR Approaches. Nanotech France 2021
SETCOR (Paris, France)
2020/09/20 Computational MitoTarget Scanning Based on Topological Vacancies of Single-Walled Carbon Nanotubes The World Conference on Nanotechnology Research & Applications (WCNR 2021)
WCNR 2021 (Prague, Czech Republic)
2019/10/02 NANOTUBOS DE CARBONO COMO POTENCIAL TERAPÊUTICO EM NANOMEDICINA MITOCONDRIAL: UM ESTUDO VIA SIMULAÇÃO COMPUTACIONAL XXI SIMPÓSIO DE ENSINO, PESQUISA E EXTENSÃO - SEPE
(Santa Maria RS, Brazil)
2018/08/20 Modelación in Silico de Biocatalizadores Inmovilizados (Enzimas y Células). Posibles Aplicaciones Productivas V Simposium BIOCATEM, UABC, Ensenada, BC, Mexico
2017/07/22 The Use of GPUs for the Acceleration of Molecular Dynamics Simulations With NAMD EGB 2017 – II Escola Gaúcha de Bioinformática
(Porto Alegre, Brazil)
2016/11/16 Data Mining for characterization of nanotoxicity in mitochondrial ion channels induced by carbon nanotubes X-Meeting 2016 - 12th International Conference of the Brazilian Association of Bioinformatics and Computational Biology (AB3C)
(Belo Horizonte, Brazil)
2016/11/07 CARBON NANOTUBES CAN PROMOTE MITOPROTECTIVE BEHAVIOR AGAINST FENTON RADICAL SIGNALING BY Fe2+-OVERLOAD: MECHANISTIC ELECTROCHEMICAL ASSAYS AND DOSE-RESPONSE PREDICTION WITH QSPR-PERTURBATION THEORY 6º Encontro do INCT de Nanomateriais de Carbono
(Curitiba, Brazil)
2014/11/30 EFECTOS EMBRIOTÓXICO Y TERATOGÉNICO DE NANOPARTÍCULAS DE PLATA EN CRÍAS DE RATAS WISTAR ALBINAS 2do Congreso Virtual de Ciencias Morfológicas. 2da Jornada Científica Virtual de la Cátedra Santiago Ramón y Cajal.
(La Habana, Cuba)
2014/07/05 A Framework for Performing Molecular Docking Simulations with Carbon Nanotubes Brazilian Symposium on Bioinformatics 2014 DCC/UFMG (X-Meeting)
(Belo Horizonte, Brazil)
2013/02/04 Efeitos embriológicos u/ou teratogênicos de nanopartículas de prata por administração oral sobre crias de ratas Wistar Albinas. Jornada Científica de Instituto de Ciências Básicas e Pré-clínicas
(La Habana, Cuba)
2012/04/12 Influencia do tamanho de nanopartículas de prata sobre sua potencialidade tóxica ao doses única pela via oral no ratos Sprague Dawley Congresso Toxicologia de Malange
(Malange, Angola)
2009/04/18 Estudo da toxicidade subcrônica de 4-hidroxibenzaldehído no ratos Sprague Dawley Congresso Internacional de Toxicologia
(La Habana, Cuba)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2010/09/01 - 2012/06/16 Efectos embriotóxico y teratogénico de nanopartículas de plata en crías de ratas Wistar
Supervisor
Universidad de Ciencias Medicas de La Habana, Cuba
2010/09/01 - 2012/05/15 Estudio de la toxicidad oral de nanopartículas de plata en ratas Sprague Dawley.
Supervisor
 Ciencias Farmacéuticas (Degree)
Universidad Agraria de la Habana, Cuba

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015/12/05 - 2015/12/05 MOL2NET, International Conference on Multidisciplinary Sciences MOL2NET, the 1st International Conference on Synergies of Experimental and Biomedical Sciences Groups with Computational Chemistry, Bioinformatics, Network Science, and Big Data Analytics Experts will be held from 5-15 December 2015 in the internet environment. The objective of this event is to bring scientists, health professionals, bioscience law experts, entrepreneurs, and engineers working in multi-disciplinary research fields to a common platform where they can present and discuss (2015/12/05)
Conference (Member of the Organising Committee)
 Universidad del País Vasco, Spain

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/03/22 - 2021/03/23 Webinar on 4th International Conference on Physical and Theoretical Chemistry
Conference
 Changing the World by Exploring the Emerging Trends in Physical and Theoretical Chemistry
Università degli Studi Roma Tre Dipartimento di Matematica e Fisica, Italy

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2010/06/15 Estudio de la potencialidad tóxica de AgNPs de 20 nm a dosis única por vía oral en ratas Sprague Dawley
Supervisor
 Nailia González Martínez (Other)
Universidad de la Habana, Cuba
2010/05/15 Estudio ecotoxicológico del análogo de brasinoesteroides DI-31 sobre organismos terrestres
(Thesis) Main arguer
 Ligbi Basha (Other)
Universidad de la Habana, Cuba
2010/05/10 Estudio fármaco-toxicológico de primera barrera de los geles Psoria 1 y Psoria 2
(Thesis) Main arguer
 Yismery León Estébanez (Other)
Universidad de la Habana, Cuba

Association member

Society Organization name Role
2007/09/01 - Current Sociedad Cubana de Toxicologia Miembro
2007 - Current Sociedad Cubana De Ciencias Farmaceuticas Miembro

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2008/09/01 - 2014/03/08 Mitochondrial Channel Toxicity an Introduction (Licence) Universidad de la Habana, Cuba
2008/09/01 - 2014/03/08 Modeling Multiple Ligand-Interactions with Mitochondrial Permeability Transition Pore-MPTP Nanotoxicologia (Licence) Centro Nacional de Toxicologiqa-CENATOX-Cuba, Cuba
2008/09/01 - 2014/03/08 Local Perturbation Response-Scanning Maps in Mito-Target Drug Discovery. Nanotoxicologia Computacional Centro Nacional de Toxicologiqa-CENATOX-Cuba, Cuba
2008/09/01 - 2014/03/08 Modeling Mitochondrial Dysfunction in Hepatotoxicity and Neurotoxicity Toxicologia (Licence) Centro Nacional de Toxicologiqa-CENATOX-Cuba, Cuba
2008/09/01 - 2014/03/08 Modeling Mitochondrial Toxicity Using Sub-Mitochondrial Particles Toxicologia (Licence) Centro Nacional de Toxicologiqa-CENATOX-Cuba, Cuba
2008/09/01 - 2014/03/08 Modeling Precision Mitochondrial Nanomedicine Nanomedicina (Licence) Centro Nacional de Toxicologiqa-CENATOX-Cuba, Cuba
2007/09/01 - 2014/02/01 Toxicologia Toxicologia (Licence) Universidad Agraria de la Habana, Cuba

Journal scientific committee

Journal title (ISSN) Publisher
2021/01/02 - 2021/01/13 BMC Cancer Springer Nature
2020/11/11 - 2020/12/01 Journal of Molecular Graphics and Modelling Elsevier
2019/05/09 - 2019/06/09 ACS Chemical Neuroscience ACS
2018/04/28 - 2018/06/30 Computational Biology and Chemistry Elsevier
Distinctions

Award

2017 PRÉMIO MCTIC DE MÉTODOS ALTERNATIVOS À EXPERIMENTAÇÃO ANIMAL
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
2006 Reconhecimento Especial do Centro de Estudos do Meio Ambiente da Universidade de la Habana - Cuba
2006 Gram Prêmio na Jornada Científica Estudantil da Faculdade de Ciências Farmacêuticas da Universidade de la Habana-Cuba