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Luis Filipe Vicente Constantino is a PI in the Medicinal Organic Chemistry group of the Research Institute for Medicines (IMED.UL), and is Assistant professor at the Faculty of Pharmacy of ULisboa. He obtained his PhD in Medicinal Chemistry in 1994 from Universidade de Lisboa (Faculdade de Farmácia) and earned his degree (Licenciatura in Ciências Farmacêuticas) in 1985 from the same faculty. Constantino has demonstrated leadership in research, serving as Principal Investigator on five funded projects and as a researcher on three others. Throughout his career, he has primarily focused on drug development for infectious diseases, particularly tuberculosis, and the teaching of Organic and Medicinal Chemistry. He has published 23 articles in peer-reviewed journals and has two more currently under review. Additionally, he has authored 5 book chapters and 1 book, holds 21 patents and patent applications, and has supervised or co-supervised 2 PhD theses, 24 MSc dissertations, and 1 postdoctoral project, receiving 3 awards and honors. His commitment to education extends beyond research; he has led numerous courses at the Faculdade de Farmácia, at both the bachelor's and master's levels, including Organic Chemistry I and II, Pharmaceutical Chemistry, Laboratory Techniques, Drug Design, Drug Analysis, and Entrepreneurship and Intellectual Property. He has also been responsible for the Drug Biochemistry course at FCUL. His service to the Faculdade de Farmácia includes roles as vice-president of the Scientific Council (2001-2003), director of the Sub-group of Organic Chemistry and Phytochemistry, and Member of the School Council (2018-2022) . Furthermore, he coordinated the Master's degree in Pharmaceutical Chemistry (1999-2007), showcasing his leadership and dedication to academic program development. Constantino has served as a court expert in 15 legal proceedings related to medicinal products and has acted as an expert witness in more than 50 court cases in the same area. He also has many years of experience in pharmaceutical regulation and has acted extensively as an expert for the European Medicines Agency. His main strength in science is the combination of his expertise in medicinal chemistry with a deep knowledge of pharmacokinetics, drug delivery, and formulation. This combination enables him to think beyond the action of a single drug on a target, to considering how can the molecule be usefully administered in vivo. Regarding project management, his strength lies in the integration of pure science with regulatory and intellectual knowledge, steering scientific projects toward actionable results.
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Identification

Personal identification

Full name
Luis Filipe Vicente Constantino

Citation names

  • Constantino, Luis

Author identifiers

Ciência ID
5110-EC82-D949
ORCID iD
0000-0002-6847-4830

Telephones

Mobile phone
  • 965488519 (Personal)

Addresses

  • IMED-UL Faculdade de Farmácia da Universidade de Lisboa Avenida Professor Gama Pinto , 1649-003, Lisboa, lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Upper intermediate (B2)
French Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
1994
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Química Farmacêutica
Universidade de Lisboa, Portugal
"Estudo do Mecanismo Molecular da Desalquilação de N, N-dial-quilamidas pelo Citocromo P 450" (THESIS/DISSERTATION)
1985/06/01
Concluded
 Ciências Farmacêuticas (Licenciatura)
Major in Farmácia Industrial
Universidade de Lisboa Faculdade de Farmácia, Portugal
 17
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
1994/11/28 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
1989/07/01 - 1994/11/27 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
1985/07/01 - 1989/06/30 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
1983/07/01 - 1985/06/30 Tutor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2022/04 - 2023/09 Potencial de derivados de ácido nitrobenzóico como fármacos antituberculose. Insights sobre o mecanismo de ação.
Provided by PTCRIS: EXPL/SAU-INF/1097/2021
EXPL/SAU-INF/1097/2021
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Uma nova arma na luta contra a tuberculose. Co-fármacos activados por esterases micobacterianas
PTDC/SAU-INF/28080/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2018/09/01 - 2021/08/31 Descoberta de fármacos inibidores de interacções proteína-proteína da p53
PTDC/QUI-QOR/29664/2017
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/12/31 Uma nova vida para velhos fármacos antimicobacterianos: desenvolvimento de pró-fármacos do ácido pirazinóico activados por esterases de micobactérias como forma de superar a resistência à pirazinamida.
PTDC/SAU-FCF/101950/2008
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/09/01 - 2013/08/31 Desenvolvimento de pró-fármacos de ácidos orgânicos fracos com potencial utilização na tuberculose
1992912
Principal investigator
Fundação Amadeu Dias
Concluded
2008 - 2010 CAPES0609 Acção do disseleneto de difenilo de proteger ou reverter o dano hepático induzido
FAPERGS 006/2010
Supervisor
Universidade Federal de Santa Maria, Brazil
1995 - 1997 PBIC/BIA/2047/95. Estudo das vias de biotransformação da primaquina
PBIC/BIA/2047/95.
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
1994 - 1997 PRAXIS /2/2.1/SAL/02/94. Estudo da malária com especial relevância para a biologia dos plasmódios, seus vectores, diagnóstico e resistência aos antimaláricos¿
PRAXIS /2/2.1/SAL/02/94
Researcher
Centro da Malária e Outras Doenças Tropicais,, Portugal
Concluded
1994/10/01 - 1994/11/30 ESTUDO DO MECANISMO MOLECULAR DA METABOLIZAÇÃO DE N, N-DIALGUILAMIDAS FARMACOLOGICAMENTE ACTIVAS
PRAXIS XXI/BD/3502/94
Researcher
The Open University, United Kingdom
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Constantino, Luis. Metabolismo de Xenobióticos. Lisboa, Portugal: Metacriações. 2004.
    Published
Book chapter
  1. Constantino, Luis; Emilia Valente; Catarina Dias. "A SN1 Reaction: Synthesis of tert-Butyl Chloride.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 14) The Royal Society of Chemistry. Published by: The Royal Society of Chemistry., edited by Afonso C A M, 64-68. London, United Kingdom: The Royal Society of Chemistry. Published by: The Royal Society of Chemistry., 2016.
    Published
  2. Constantino, Luis; Catarina Dias; Emilia Valente. "Synthesis of Paracetamol by Acetylation.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 32) The Royal Society of Chemistry., edited by Afonso C A M, 146-150. London, United Kingdom: The Royal Society of Chemistry., 2016.
    Published
  3. Constantino, Luis; Emilia Valente; Catarina Dias. "Acetylation of Cholesterol and Purification by Column Chromatography.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 36,) The Royal Society of Chemistry., edited by Afonso C A M, 162-167. London, United Kingdom: The Royal Society of Chemistry., 2016.
    Published
  4. Constantino, Luis; Catarina Dias; Emilia Valente. "Reduction of a Ketone Using Sodium Borohydride. Control of a Reaction by TLC.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. (Chapter 196) The Royal Society of Chemistry., edited by Afonso C A M, 886-891. London, United Kingdom: The Royal Society of Chemistry., 2016.
    Published
  5. Constantino, Luis. "Oxidative dealkylation of N,N-dialkylbenzamides.". In Cytochrome P 450, Biochemistry, Biophysics and Molecular Biology, edited by Lechner M. C., 677-680. Paris, France: Jonh Libbey Eurotext,, 1994.
    Published
Conference paper
  1. Dias, Catarina; Testa, Bernard; Soveral, Graça; Constantino, Luís; Dias, Mário. "The effect of xenobiotics on rat liver alcohol dehydrogenase activity or how medicines can affect the metabolism of alcohol". 2009.
  2. Constantino, Luis; Luisa Jordão; Elsa Anes. "Formulation and activity of liposome encapsulated ß-lactam antibiotics in macrophages infected with mycobacteria. Article in the 8th virtual AIDS congress". Paper presented in 8th virtual AIDS congress (http://www.aidscongress.net/pdf/338.pdf), 2007.
Journal article
  1. João P. Pais; Olha Antoniuk; Raquel Freire; David Pires; Emília Valente; Elsa Anes; Luis Constantino. "Nitrobenzoates and Nitrothiobenzoates with Activity against M. tuberculosis". Microorganisms (2023): https://doi.org/10.3390/microorganisms11040969.
    10.3390/microorganisms11040969
  2. João P. Pais; Marta Magalhães; Olha Antoniuk; Ivete Barbosa; Raquel Freire; David Pires; Emília Valente; et al. "Benzoic Acid Derivatives as Prodrugs for the Treatment of Tuberculosis". Pharmaceuticals (2022): https://doi.org/10.3390/ph15091118.
    10.3390/ph15091118
  3. J. P. Pais; Margarida Policarpo; Pires D; Francisco AP; Ana Margarida Madureira; Bernard Testa; Anes, E; Luis Constantino. "Fluoroquinolone Derivatives in the Treatment of Mycobacterium tuberculosis Infection". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/10/1213.
    10.3390/ph15101213
  4. Emília Valente; Bernard Testa; Luís Constantino. "Activation of benzoate model prodrugs by mycobacteria. Comparison with mammalian plasma and liver hydrolysis". European Journal of Pharmaceutical Sciences 162 (2021): 105831-105831. https://doi.org/10.1016/j.ejps.2021.105831.
    10.1016/j.ejps.2021.105831
  5. Pires, D.; Valente, E.; Simões, M.F.; Carmo, N.; Testa, B.; Constantino, L.; Anes, E.. "Esters of pyrazinoic acid are active against pyrazinamide-resistant strains of Mycobacterium tuberculosis and other naturally resistant mycobacteria in vitro and ex vivo within macrophages". Antimicrobial Agents and Chemotherapy 59 12 (2015): 7693-7699. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954501338&partnerID=MN8TOARS.
    10.1128/AAC.00936-15
  6. Prigol, M.; Nogueira, C.W.; Zeni, G.; Bronze, M.R.; Constantino, L.. "Physicochemical and biochemical profiling of diphenyl diselenide.". Applied biochemistry and biotechnology 169 3 (2013): 885-893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882976706&partnerID=MN8TOARS.
    10.1007/s12010-012-0042-9
  7. Prigol, M.; Nogueira, C.W.; Zeni, G.; Bronze, M.R.; Constantino, L.. "In vitro metabolism of diphenyl diselenide in rat liver fractions. Conjugation with GSH and binding to thiol groups". Chemico-Biological Interactions 200 2-3 (2012): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868261138&partnerID=MN8TOARS.
    10.1016/j.cbi.2012.09.007
  8. Mata, G.; Do Rosário, V.E.; Iley, J.; Constantino, L.; Moreira, R.. "A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation". Bioorganic and Medicinal Chemistry 20 2 (2012): 886-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855803114&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.11.059
  9. Dias, Catarina; Testa, Bernard; Soveral, Graça; Dias, Mário; Constantino, Luís; Dias, C.; Testa, B.; et al. "Screening of the inhibitory effect of xenobiotics on alcohol metabolism using S9 rat liver fractions". Toxicology in Vitro 26 7 (2012): 1177-1180. http://dx.doi.org/10.1016/j.tiv.2012.06.011.
    http://dx.doi.org/10.1016/j.tiv.2012.06.011
  10. Valente, E.; Simões, M.F.; Testa, B.; Constantino, L.. "Development of a method to investigate the hydrolysis of xenobiotic esters by a Mycobacterium smegmatis homogenate". Journal of Microbiological Methods 85 2 (2011): 98-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953214901&partnerID=MN8TOARS.
    10.1016/j.mimet.2011.02.003
  11. Simoes, Marta Filipa; Valente, Emilia; Rodriguez Gomez, M. Jose; Anes, Elsa; Constantino, Luis; Simões, M.F.; Valente, E.; et al. "Lipophilic pyrazinoic acid amide and ester prodrugs Stability, activation and activity against M. tuberculosis". European Journal of Pharmaceutical Sciences 37 3-4 (2009): 257-263. http://hdl.handle.net/10451/21171.
    http://dx.doi.org/10.1016/j.ejps.2009.02.012
  12. Gu, P.; Constantino, L.; Zhang, Y.. "Enhancement of the antituberculosis activity of weak acids by inhibitors of energy metabolism but not by anaerobiosis suggests that weak acids act differently from the front-line tuberculosis drug pyrazinamide". Journal of Medical Microbiology 57 9 (2008): 1129-1134. http://www.scopus.com/inward/record.url?eid=2-s2.0-51149085652&partnerID=MN8TOARS.
    10.1099/jmm.0.2008/000786-0
  13. Constantino, L.; Iley, J.. "Oxidation of tertiary benzamides by 5,10,15,20-tetraphenyl- porphyrinatoironIII chloride-tert-butylhydroperoxide". Organic and Biomolecular Chemistry 2 13 (2004): 1894-1900. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142769088&partnerID=MN8TOARS.
    10.1039/b404169k
  14. Iley, J.; Tolando, R.; Constantino, L.. "Erratum: Chemical and microsomal oxidation of tertiary amides: Regio- and stereoselective aspects (Journal of the Chemical Society, Perkin Transactions 2 (2001) (1299-1300))". Journal of the Chemical Society, Perkin Transactions 2 11 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0035765061&partnerID=MN8TOARS.
  15. Iley, J.; Tolando, R.; Constantino, L.. "Chemical and microsomal oxidation of tertiary amides: Regio- and stereoselective aspects". Journal of the Chemical Society, Perkin Transactions 2 8 (2001): 1299-1305. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034741458&partnerID=MN8TOARS.
  16. Constantino, L.; Paixão, P.; Moreira, R.; Portela, M.J.; Do Rosario, V.E.; Iley, J.. "Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine". Experimental and Toxicologic Pathology 51 4-5 (1999): 299-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032781772&partnerID=MN8TOARS.
  17. Portela, M.J.; Moreira, R.; Valente, E.; Constantino, L.; Iley, J.; Pinto, J.; Rosa, R.; Cravo, P.; Do Rosario, V.E.. "Dipeptide derivatives of primaquine as transmission-blocking antimalarials: Effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates". Pharmaceutical Research 16 6 (1999): 949-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033020951&partnerID=MN8TOARS.
    10.1023/A:1018922425551
  18. Constantino, L.; Iley, J.. "Microsomal metabolism of N,N-diethyl-m-toluamide (DEET, DET): The extended network of metabolites". Xenobiotica 29 4 (1999): 409-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032941780&partnerID=MN8TOARS.
    10.1080/004982599238588
  19. Iley, J.; Constantino, L.. "The microsomal dealkylation of N,N-dialkylbenzamides". Biochemical Pharmacology 47 2 (1994): 275-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027979620&partnerID=MN8TOARS.
    10.1016/0006-2952(94)90017-5
  20. Constantino, L.; Mehta, R.T.; Cruz, M.E.; Lopez-Berestein, G.. "Formulation and toxicity of liposomes containing rifampicin". Journal of Liposome Research 3 2 (1993): 275-301. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027217238&partnerID=MN8TOARS.
    10.3109/08982109309148215
  21. Constantino, L.; Rosa, E.; Iley, J.. "The microsomal demethylation of N,N-dimethylbenzamides. Substituent and kinetic deuterium isotope effects". Biochemical Pharmacology 44 4 (1992): 651-658. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026662342&partnerID=MN8TOARS.
    10.1016/0006-2952(92)90399-4
  22. Iley, J.; Constantino, L.; Norberto, F.; Rosa, E.. "Oxidation of the methyl groups of N,N-dimethylbenzamides by a cytochrome P450 mono-oxygenase model system". Tetrahedron Letters 31 34 (1990): 4921-4922. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024989694&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)97769-4
  23. Constantino, Luis; Eugénia Cruz. "Liposomes containing rifampicin". Ciencia Biologica - Molecular and cClular Biology) 14 (1989): 1-8.
    Published
Thesis / Dissertation
  1. Constantino, Luis. "Estudo do mecanismo molecular da desalquilação de N,N-dialquilamidas pelo citocromo P450,". PhD, Universidade de Lisboa Faculdade de Farmácia, 1994.

Intellectual property

Patent
  1. Constantino, Luis; Elsa Anes; Marta Simões; Emilia Valente. 2017. "Pró-fármacos de ácidos orgânicos e composições farmacêuticas contendo os referidos pró-fármacos". Portugal.
    Granted/Issued
  2. Constantino Luis Filipe Vicente; Anes Elsa Maria Ribeiro Santos; Simoes Marta Filipa Jesus De Freitas; Valente Emilia Alice Dos Reis Torroaes. 2013. "EA 018246 B1 VESICULAR FORMULATIONS CONTAINING ORGANIC ACID DERIVATIVES, AND PROCESS FOR THEIR PREPARATION".
  3. Constantino Luis Filipe Vicente; Anes Elsa Maria Ribeiro; Valente Emilia Alice Torroaes; Almeida Teresa Sofia Baptista De; Carmo Nuno Baltazar Do. 2013. "PRÓ-FÁRMACOS DO ÁCIDO PIRAZINÓICO ACTIVADOS POR ESTERASES DE MICOBACTÉRIAS". Portugal.
  4. Constantino, Luis; Anes Elsa; Valente, Emilia; Simões Marta; Simoes Marta Filipa Jesus De F. 2013. "CN 101460146 Vesicular formulations containing organic acid prodrugs, process for their preparation". China.
    Granted/Issued
  5. Constantino Luis Filipe Vicent; Anes Elsa Maria Ribeiro Santos; Simoes Marta Filipa Jesus De Freitas; Valente Emilia Alice Dos Reis Torroaes. 2007. "FORMULAÇÕES VESICULARES CONTENDO PRÓ-FÁRMACOS DE ÁCIDOS ORGÂNICOS, SEU PROCESSO DE PREPARAÇÃO, NOVOS PRÓ-FÁRMACOS E COMPOSIÇÕES FARMACÊUTICAS". Portugal.
  6. Constantino, Luis; Manuela Gaspar; Eugénia Cruz; Gabriel Lopez-Berestein. 1999. "PT100487B Formulacoes lipossomais de rifamicinas com elevada estabilidade e eficacia de incorporacao de antibiotico, e processo para a sua preparacao". Portugal.
    Granted/Issued
  7. Constantino, Luis; Eugenia cruz; Gabriel Lopez-Berestein; Manuela Gaspar; Reetha Metha. 1992. "Formulações lipossomais de Rifampicina com Elevada Eficácia de Incorporação de Antibiótico e Processo para a sua Preparação". Portugal.
    Granted/Issued
Provisional application for patent
  1. 2023. "118464 (INPI). Compostos tioesteres, métodos de obtenção e seu uso".
    Protected
  2. 2022. "118236. (INPI). Nitrobenzamide compounds, methods and uses thereof".
    Protected
  3. 2022. "European Patent Application EP22199255.(EPO) Nitrobenzamide compounds, methods and uses thereof .".
    Protected
  4. 2022. "118234 (INPI). Benzoic acid derivatives, methods and uses thereof.".
    Protected
  5. 2022. "European Patent Application EP22199251 (EPO). ). Benzoic acid derivatives, methods and uses thereof.".
    Protected
  6. 2013. "PYRAZINOIC ACID PRODRUGS ACTIVATED BY ESTERASES OF MYCOBACTERIA".
    Disclosed
  7. 2011. "PT 106051 - Pró-fármacos do ácido pirazinóico activados por esterases de micobactérias".
    Disclosed
  8. 2010. "USA App US/2010/0221315A1 VESICULAR FORMULATIONS CONTAINING ORGANIC ACID PRODRUGS, PROCESS FOR THEIR PREPARATION".
    Disclosed
  9. 2009. "EU App 07747764.4 VESICULAR FORMULATIONS CONTAINING ORGANIC ACID PRODRUGS AND PROCESS FOR THEIR PREPARATION.".
    Disclosed
  10. 2008. "VESICULAR FORMULATIONS CONTAINING ORGANIC ACID PRODRUGS, PROCESS FOR THEIR PREPARATION".
    Protected
  11. 2008. "India App 2733/MUMNP/2008 Vesicular formulations containing organic acid prodrugs".
    Disclosed
  12. 2007. "VESICULAR FORMULATIONS CONTAINING ORGANIC ACID PRODRUGS, PROCESS FOR THEIR PREPARATION, NEW PRODRUGS, PHARMACEUTICAL COMPOSTIONS AND METHOD FOR THE TREATMENT OF TUBERCULOSIS AND OTHER MYCOBACTERIOSIS".
    Protected
  13. 1993. "FORMULACOES LIPOSSOMAIS DE RIFAMICINAS COM ELEVADA ESTABILIDADE E EFICACIA DE INCORPORACAO DE ANTIBIOTICO, E PROCESSO PARA A SUA PREPARACAO".
  14. 1993. "LIPOSOMAL FORMULATIONS CONTAINING RIFAMYCINS".
    Disclosed
Distinctions

Award

2006 Prémio COHITEC 2006. Melhor plano de negócios para um para um projeto de base científica
1993 Prémio Ordem dos Farmacêuticos 1993
Ordem dos Farmaceuticos, Portugal

Title

2017 Elsevier Certificate of outstanding contribution on reviewing for Chemico-Biological Interactions
Elsevier BV, Netherlands