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Cláudio Maia is graduated in Biochemistry and PhD in Biomedicine. He is Associate Professor and integrated researcher at Health Sciences Research Center (CICS-UBI). In addition, he is vice-coordinator of Hormones & Metabolism Group of CICS-UBI and is member of the body responsible for animal welfare (ORBEA) of UBI. As investigator, he has published 72 articles in peer-reviewed journals, and supervise(d)/co-supervise(d) 29 masters students and 10 PhD students. The main scientific focus includes to explore the cellular and molecular mechanisms underlying prostate cancer, as well as to evaluate the usefulness of novel biomarkers and to explore novel strategies of treatment. As know-how technical, it can be highlighted his expertise in cell culture and animal experiments, and in several assays to evaluate gene expression (qPCR, western blot, and immunohistochemistry), assays of cell viability, cell cycle, and apoptosis (MTS, Ki-67, Tunel, Caspase-3 activity, etc). Regarding his main focus of investigation, the ongoing projects intend to: i) characterize the role and regulation of Six Transmembrane Epithelial of the Prostate 1 (STEAP1) proteins in prostate cancer; ii) evaluate the usefulness of STEAP1 as a biomarker or putative therapeutic target; and iii)- explore novel approaches for the treatment of prostate cancer.
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Identification

Personal identification

Full name
Cláudio Jorge Maia Baptista

Citation names

  • Maia C J B
  • Maia, Cláudio J. B.
  • Maia CJ
  • Maia C

Author identifiers

Ciência ID
5115-FCBD-A31F
ORCID iD
0000-0002-5658-5445
Google Scholar ID
https://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
Researcher Id
H-9320-2012
Scopus Author Id
23097426600

Email addresses

  • cmaia@fcsaude.ubi.pt (Professional)

Telephones

Telephone
  • (351) 275329068 (Professional)

Addresses

  • Universidade da Beira Interior, Faculdade de Ciências da Saúde, Departamento de Ciências Médicas. Av. Infante D. Henrique, 6200-506, Covilhã, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2012 - 2012
Concluded
 XI Curso de Experimentação Animal (nível C) (Pós-Graduação)
Universidade de Lisboa, Portugal
 15
2003 - 2008
Concluded
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
"Novel genes differentially expressed in breast and prostate cancer: effect of sex steroid hormones" (THESIS/DISSERTATION)
 NA
1998 - 2003
Concluded
 Bioquímica (Licenciatura)
Universidade da Beira Interior, Portugal
"Determinação da organização genómica do gene do receptor da hormona do crescimento na dourada (Sparus aurata) e no peixe dourado (Carassius auratus)" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2009 - Current Principal Investigator (Research) Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2003 - 2008 Researcher (Research) Fundação para a Ciência e a Tecnologia, I.P., Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2005/01/01 - 2005/07/31 Research Trainee (Research) Instituto de Biología Molecular y Celular del Cáncer, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2023/07 - Current Associate Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2010 - 2023/06 Assistant Professor (University Teacher) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2009 - 2009 Invited Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
2008/01 - 2008/12 Assistant (University Teacher) Universidade da Beira Interior, Portugal
2006 - 2007 Tutor (University Teacher) Universidade da Beira Interior, Portugal

Others

Category
Host institution 		Employer
2021 - Current Vice-coordinator of Hormones & Metabolism Group of CICS-UBI Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
Centro de Investigação em Ciências da Saúde (CICS), Portugal
2018 - Current Scientific representative of the professors of the body responsible for animal welfare (ORBEA) of the University of Beira Interior. Universidade da Beira Interior, Portugal
2020 - 2021/04 Member of team responsible to organize and implement a diagnostic test (qPCR) for COVID-19 in "Cova da Beira" region Hospital Pêro da Covilhã, Portugal
2020/04/20 - 2020/07/31 Volunteer in Laboratory for COVID-19 diagnostic tests Hospital Pêro da Covilhã, Portugal
Projects

Grant

Designation Funders
2003/12 - 2007/11 Novel genes differentially expressed in breast and prostate cancer: effect of sex steroid hormones
BD/13388/2003
 Ministério da Ciência Tecnologia e Ensino Superior

Contract

Designation Funders
2020 - 2023/06 CICS4COVID- Test, Track, and innovate in the diagnosis of COVID-19
02/SAICT/2020- 72541
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019 - 2022 C4- Cloud Computing Competence Centre. Research Line 2 Cloud Applications
WP 2.6 - Bioinformatics
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021 Shaping prostate cell metabolism by extrinsic factors: insights into cancer prevention, diagnosis and treatment
POCI-01-0145-FEDER-029114
 Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 Health Sciences Research Centre
UID/Multi/00709/2019
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Hormonal and Inflammatory basis of age-related diseases
CENTRO-07-ST24-FEDER-002015
 Programa Operacional Regional do Centro 2007-2013 QREN (Programa “Mais Centro”)
Concluded
2013/06 - 2014/05 Biosynthesis, purification and biointeraction of human soluble catechol-O-methyltransferase with Parkinson´s inhibitors
Provided by PTCRIS: 128284
128284
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 709 - 2011-2012
PEst-C/SAU/UI0709/2011
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2013 Amniotic membrane: a therapeutic option against cancer?
CIMAGO 07/12
Researcher
Associação de Apoio ao Centro de Investigação em Meio Ambiente, Genética e Oncobiologia

Other

Designation Funders
2019 - 2024 Extrinsic factors in the modulation of prostate metabolism: applications in cancer prevention, diagnosis and treatment
DGAV
Principal investigator
Ongoing
2021 - 2022 Structural Determination and Function Analysis of the STEAP1 Protein: Towards a New Target for Cancer Treatment
Instruct-ERIC, PID: 11936
Researcher
Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Barroca-Ferreira, J.; Maia, C.J.; Passarinha, L.A.. "Mini-Bioreactor Platform for Membrane Protein Production in Komagataella pastoris". 35-54. 2023.
    10.1007/978-1-0716-3147-8_3
  2. Rocha, Sandra M; Barroca-Ferreira, Jorge; Passarinha, Luís A; Socorro, Sílvia; Maia, Cláudio J. "The Usefulness of STEAP Proteins in Prostate Cancer Clinical Practice". In Prostate Cancer, 139-154. Exon Publications, 2021.
    Published • 10.36255/exonpublications.prostatecancer.steap.2021
  3. Rocha SM; Maia, C J. "Biochemical Properties of Amniotic Membrane". In Amniotic Membrane: Origin, Characterization, and Medical Applications, NA-NA. Netherlands: Springer Netherlands, 2015.
    Published
  4. Vaz CV; Alves M; Marques R.; Oliveira PF; Maia CJ; Socorro S. "Glucose Uptake and Androgen Responsiveness of Prostate Cancer Cells". In Glucose Uptake: Regulation, Signaling Pathways and Health Implications, 193-214. New York, USA: Nova Science Publishers, Inc, 2013.
    Published
  5. Gomes, I. M.; Vaz CV; Rodrigues D; Rocha SM; Santos, C. R.; Socorro S; Maia, C.J.. "Estrogens and prostate cancer: from biosynthesis to physiological effects". In Estradiol synthesis: health effects and drug interactions, N.A.-N.A.. New York, USA: Nova Science Publishers, Inc, 2013.
    Published
Conference abstract
  1. Rafaella Coelho1, Sandra M Rocha, Sílvia Socorro and Cláudio J Maia. "STEAP1 knockdown decreases the sensitivity of prostate cancer cells to taxanes-based chemotherapeutics". Paper presented in International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Challenges from Research to Clinic, Covilhã, 2023.
    Published
  2. Margarida Carvalho, Rui Gomes, Sandra Moreira Rocha, Jorge Barroca-Ferreira, Cláudio J. Maia, Lúcia Guillade, Miguel A.. "Development of an electrochemical biosensor for the detection of a biomarker associated with prostate cancer". Paper presented in IV International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Challenges from Research to Clinic, Covilhã, 2023.
    Published
  3. Maia, Cláudio J. B.. "UBI and CICS in my journey". Paper presented in XVIII International CICS-UBI Symposium, 2023.
  4. André Miranda, Bruno Baptista, Fani Sousa, Cláudio J Maia, Silvia Socorro, Carla Cruz. "Sensitive fluorescent detection of Sars-CoV-2 RNA using an enzymatic-based method.". Paper presented in XVII International CICS-UBI Symposium, Covilhã, 2022.
    Accepted
  5. Cristiana Mateus, Cláudio Maia, Fernanda Domingues, Roland Bücker, Mónica Oleastro, Susana Ferreira. "Effect of exposure to bile salts in virulence traits of aliarcobacter butzleri". Paper presented in XVII International CICS-UBI Symposium, Covilhã, 2022.
    Published
  6. Barroca-Ferreira J, Santos MFA, Santos-Silva T, Maia CJ, Passarinha LA.. "A Molecular Perspective on the Bio-Structural Properties of the Human Native Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1)". Paper presented in The 24th Meeting for the International Society on Molecular Recognition – Affinity, Lisbon, 2021.
    Published
  7. Cristiana Mateus, Cláudio Maia, Fernanda Domingues, Roland Bücker, Mónica Oleastro, Susana Ferreira.. "Evaluation of Aliarcobacter butzleri response to bile salts.". Paper presented in MicroBiotec21., 2021.
    Published
  8. Barroca-Ferreira J, Santos-Silva T, Maia CJ, Passarinha LA.. "Separation of Histidine-Tagged Six-Transmembrane Epithelial Antigen of the Prostate 1 from Detergent-Solubilized Komagataella pastoris Extracts". Paper presented in 40th International Symposium on the Purification of Proteins, Peptides and Polynucleotides, 2021.
  9. Sandra M Rocha, Sílvia Socorro, Luís A Passarinha, Cláudio J. Maia. "STEAP family members expression in human cancers: unraveling the potential usefulness in clinical practice using bioinformatics tools.". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
    Published
  10. Barroca-Ferreira, J.; Santos-Silva T; Maia CJ; Passarinha LA. "Flowsheet Optimization for the Isolation of Recombinant STEAP1 from Komagataella pastoris Bioreactor Cultures". Paper presented in III International Conference NOVAHealth Cronic Disease and Infection, Lisbon, 2020.
    Published
  11. Barroca-Ferreira J, Rocha SM, Santos-Silva T, Maia CJ, Passarinha LA. "A novel procedure for expression and isolation of cancer-associated antigen 1". Paper presented in 6th ENBENG- IEEE Portuguese Meeting in Bioengineering. 22-23 February 2019, Lisbon, Portugal, 2019.
    Published
  12. Barroca-Ferreira J, Rocha Sandra, Santos-Silva Teresa, Maia Cláudio, Passarinha Luís. "Design of a single step chromatographic strategy for the isolation of the cancer-associated antigen STEAP1". Paper presented in ECCE12 and ECAB5, 15-19 September 2019, Florence, Italy, 2019.
    Published
  13. Fonseca L., Alves L., Serra C., Maia CJ., Vaz CV., Socorro S. "Regucalcin overexpression prevents aging-associated alterations in rat prostate: oxidative stress, apoptosis and metabolism". Paper presented in III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Aging and Cancer, 14th-16th November 2019, Covilhã, Portugal, 2019.
    Published
  14. Silva AMS, Socorro S, Vaz CV, Correia S, Maia CJ. "Regucalcin protein alleviates ageing-related changes in rat testis". Paper presented in III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Aging and Cancer, 14th-16th November 2019, Covilhã, Portugal, 2019.
    Published
  15. Jorge Barroca-Ferreira, Teresa Santos-Silva, Cláudio J. Maia, Luís A. Passarinha. "Classical chromatography or co-immunoprecipitation: which is the most effective strategy for the isolation of the cancer protein STEAP1?". Paper presented in III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Aging and Cancer, 14th-16th November 2019, Covilhã, Portugal, 2019.
    Published
  16. Sandra M Rocha, Fátima M Santos, Luís A. Passarinha, Sílvia Socorro, Cláudio J Maia. "Proteomic analysis of human prostate cancer LNCaP cells upon STEAP1 knockdown". Paper presented in III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Aging and Cancer, 14th-16th November 2019, Covilhã, Portugal, 2019.
    Published
  17. Passarinha LA, Monteiro DP, Duarte DR, Santos FM, Maia CJ. "Performance of traditional hydrophobic ligands on isolation of Six Transmembrane Epitelial Antigen of the Prostate 1". Paper presented in 12th ESBES (European Symposium on Biochemical Engineering Science), 9-12 September 2018; Lisbon, Portugal, 2018.
    Published
  18. Eusébio D, Almeida AM, Alves J, Maia CJ, Queiroz JA, Sousa F, Sousa A. "Recombinant p-53 minicircular DNA: from vector construction to biopharmaceutical purification.". Paper presented in 12th ESBES (European Symposium on Biochemical Engineering Science), 9-12 September 2018; Lisbon, Portugal, 2018.
    Published • 10.1142/9789814719810_0089
  19. Maia CJ. "Overexpression of the calcium-binding protein regucalcin mitigates the age-associated changes in oxidative stress and semen quality". Paper presented in 20th Congress of the European Society for Sexual Medicine & 21st World Meeting of the International Society for Sexual Medicine. 28th February to 3rd March 2018, Lisbon Congress Center, Lisbon, Portugal, 2018.
    Published
  20. Silva AMS, Correia S., Socorro S, Maia CJ. "Regucalcin overexpression prevents the age-associated decline of sperm quality". Paper presented in II International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Biotechnology for Biomedical Applications, 17th-20th May 2017, Covilhã, Portugal, 2017.
    Published
  21. Maia CJ. "Minicircular DNA as a potential gene therapy vector in cervical cancer". Paper presented in II International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Biotechnology for Biomedical Applications, 17th-20th May 2017, Covilhã, Portugal, 2017.
    Published
  22. Duarte DR, Pedro AQ, Maia CJ, Passarinha LA. "Improvement of STEAP 1 biosynthesis from Pichia pastoris X33 cells under an optimized feeding strategy". Paper presented in . II International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Biotechnology for Biomedical Applications, 17th-20th May 2017, Covilhã, Portugal., 2017.
    Published
  23. Jorge Ferreira, João Pais, Margarida Santos, Diana Duarte, Augusto Pedro, Cláudio Maia, Luís Passarinha. "Evaluation of Escherichia coli and Pichia Pastoris hosts in the biosynthesis of STEAP1: a membrane therapeutic target for prostate cancer". Paper presented in 9th Conference on Recombinant Protein Production (RPP9), 23rd – 25th April 2017, Dubrovnik, Croatia., 2017.
  24. Vaz CV, Marques R, Maia CJ, Socorro S.. "Regucalcin in hormone-dependent cancers: towards a candidate tumour suppressor gene?". Paper presented in European Association for Cancer Research (EACR 24), 9-12 July 2016, Manchester, UK., 2016.
    Published
  25. Ignacio Verde, Elisa Cairrão, Cláudio Maia, Isabel Neto, Carla Fonseca, Olga Lourenço. "Integración Curricular en Medicina: la Clave Para la Colaboración Interdisciplinar". Paper presented in XIII Foro Sobre Evaluación de la Calidad de la Investigación y de la Educación Superior (2016), Granada, Spain, 2016.
    Published
  26. Mamede, A. C.; Alves, AP; Laranjo M; Carvalho, M. J.; Moura, P.; Abrantes, A. M.; Maia, C. J.; Botelho, M. F.. "Cancer cell death profile induced by human amniotic membrane extracts treatment". Paper presented in Actualizações em Oncologia 2015 - 4.º Congresso do CIMAGO, Coimbra, Portugal, 2015.
    Published
  27. Alves, AP; Mamede, A. C.; Carvalho, M. J.; Moura, P.; Abrantes, A. M.; Botelho, M. F.; Maia CJ. "Hepatocellular carcinoma therapy based on human amniotic membrane: inhibition of GLUT and PgP expression". Paper presented in Actualizações em Oncologia 2015 - 4.º Congresso do CIMAGO, Coimbra, 2015.
    Published
  28. Figueira MI, Correia S, Vaz CV, Cardoso HJ, Gomes IM, Marques R, Maia CJ and Socorro S.. "Estrogenic actions in the prostate: are the stem cell factor (SCF) and c-KIT receptor involved?". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences, 26th-28th November 2015, Covilhã, Portugal, 2015.
    Published
  29. Marques R, Peres CG, Vaz CV, Gomes IM, Figueira MI, Cairrão E, Verde I, Maia CJ and Socorro S.. "Androgens as calcium-modulators in human breast cancer cells: effects of 5a-dihydrotestosterone in MCF-7 cells". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences, 26th-28th November 2015, Covilhã, Portugal, 2015.
    Published
  30. Alves AP, Mamede AC, Alves MG, Oliveira PF, Carvalho MJ, Moura P, Abrantes AM, Botelho MF, Maia CJ.. "Hepatocellular carcinoma therapy based on human amniotic membrane glycolytic and resistance profile study". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences, 26th-28th November 2015, Covilhã, Portugal., 2015.
    Published
  31. Ana M. S. Silva, Sara Correia, João Casalta-Lopes, Ana C. Mamede, José E. Cavaco, Maria F. Botelho, Cláudio J. Maia. "The androgen-target gene regucalcin as an apoptosis modulator in irradiated rat testis.". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences, 26th-28th November 2015, Covilhã, Portugal., 2015.
    Published
  32. Mamede AC; Guerra S; Laranjo M; Santos K; Carvalheiro T; Carvalho MJ; Moura P; et al. "Hepatocellular carcinoma treatment with human amniotic membrane extract: assembling a cellular puzzle". Paper presented in 3rd IPLASS meeting, Granada, 2014.
    Published
  33. Mamede AC; Guerra S; Laranjo M; Carvalho MJ; Pires AS; Brito AF; Moura P; et al. "Extraction, identification and metabolic effect of amniotic membrane proteins in human cancer cell lines". Paper presented in Actualizações em Oncologia 2014 - 3.º Congresso do CIMAGO, Coimbra, 2014.
    Published
  34. Guerra S; Mamede AC; Laranjo M; Pires AS; Carvalho MJ; Brito AF; Moura P; et al. "Human amniotic membrane secreted factors plus chemotherapy: a mishmash of effects?". Paper presented in 23rd Meeting of the European Association for Cancer Research (EACR-23), Munich, 2014.
    Published
  35. Guerra S; Mamede AC; Brito AF; Laranjo M; Carvalho MJ; Moura P; Abrantes AM; Maia CJ; Botelho MF. "Human amniotic membrane secreted factors: association with conventional chemotherapy for hepatocellular carcinoma therapy". Paper presented in 3rd IPLASS meeting, Granada, 2014.
    Published
  36. Guerra S; Mamede AC; Laranjo M; Carvalho MJ; Brito AF; Pires AS; Santos K; et al. "Amniotic membrane: a new approach for liver malignancy". Paper presented in Actualizações em Oncologia 2014 - 3.º Congresso do CIMAGO, Coimbra, 2014.
    Published
  37. Vaz CV; Alves, M.; Marques, R.; Moreira PI; Oliveira, P. F.; Cavaco JE; Maia, C. J.; Socorro, S.. "Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells.". Paper presented in 16th European Congress of Endocrinology, Wroclaw, 2014.
    Published
  38. Mamede, A C; Guerra S; Laranjo, M; Brito, A. F.; Pires, A. S.; Carvalho, M. J.; Moura, P.; et al. "Anti-cancer proteins found in amniotic membrane: extraction, identification and cellular effects.". Paper presented in European Association for Cancer Research (EACR 23), Munich, 2014.
    Published
  39. Mamede, A. C.; Guerra, S.; Laranjo, M; Brito, A. F.; Santos, K.; Carvalho, M. J.; Tralhão JG; et al. "Human amniotic membrane-derived proteins display anticancer activity in hepatocellular carcinoma". Paper presented in EASL HCC Summit: Molecular Pathogenesis and Translational Research in Liver Cancer, Genebra, Switzerland, 2014.
    Published
  40. Marques, Ricardo; Vaz, Cátia V.; Gomes, Inês M; Cairrao, E.; Verde, I.; Maia, C. J.; Socorro, Sílvia; Maia CJ. "L-type Ca2+ channels in breast cancer MCF-7 cells: identification and regulation by androgens". Paper presented in FEBS-EMBO Congress, Paris, France, 2014.
    Published
  41. Gomes, Inês M; Gaspar, C; Alvelos, MI; Santos, C. R.; Maia, C. J.. "Effect of down-regulation of STEAP1 by siRNA in cell cycle and apoptosis of human LNCaP prostate cells". Paper presented in FEBS-EMBO Congress, Paris, France, 2014.
    Published
  42. Mamede, A. C.; Guerra, S.; Alves, AP; Carvalho, M. J.; Gonçalves, A. C.; Sarmento-Ribeiro, A B; Moura P; et al. "Cell death and oxidative stress profile in human hepatocellular carcinoma cell lines after treatment with amniotic membrane-derived proteins". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014.
    Published
  43. Vaz, Cátia V.; Maia, C. J.; Marques, Ricardo; Gomes, Inês M; Correia, Sara; Alves, M.; Cavaco JE; Oliveira, P. F.; Socorro, Sílvia. "Regucalcin, a new androgen target gene involved in the regulation of prostate cell growth". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014.
    Published
  44. Marques, Ricardo; Vaz, Cátia V.; Maia, C. J.; Gomes, M; Gama, A; Alves, G; Santos, C. R.; Schmitt, Fernando; Socorro, Sílvia. "Clinicohistopathological and in vivo evidences". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014.
    Published
  45. Cardoso HJ; Vaz, Cátia V.; Correia, Sara; Figueira MI; Marques, Ricardo; Maia, C. J.; Socorro, Sílvia. "Paradoxical and contradictory effects of imatinib in two cell line models of prostate cancer". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014.
    Published
  46. Figueira MI; Correia, Sara; Vaz, Cátia V.; Cardoso HJ; Gomes, Inês M; Marques, Ricardo; Maia, C. J.; Socorro, Sílvia. "The estrogenic regulation of stem cell factor (SCF) and c-KIT in rat prostate supports the protective role of estrogens in prostate cancer". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014.
    Published
  47. Maia CJ; Maia C; Vaz, Cátia V.; Marques, Ricardo; Cavaco, J. E.; Maia, C. J.; Socorro, Sílvia. "Regucalcin, a calcium (Ca2+)-binding protein with a protective role in prostate age-related diseases?". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, 2014.
    Published
  48. Vaz CV; Alves M; Marques R.; Oliveira PF; Maia CJ; Socorro S. "Glucose Metabolism and Androgen Responsiveness of Prostate Cancer Cells". Paper presented in 13th Young Scientists Forum (YSF)/38th FEBS Congress, St Petersburg, 2013.
    Published
  49. Marques R.; Vaz CV; Maia CJ; Gama A; Alves M; Schmitt, F.; Santos, C. R.; Socorro S. "Transgenic rats overexpressing Regucalcin display lower-susceptibility to develop DMBA-induced mammary gland tumors". Paper presented in 13th Young Scientists Forum (YSF)/38th FEBS Congress, St Petersburg, 2013.
    Published
  50. Gonçalves AC; Maia, C; Passarinha, L.A.. "Biosynthesis and isolation of STEAP1 peptides for prostate cancer immunotherapy". Paper presented in 13th Young Scientists Forum (YSF)/38th FEBS Congress, St Petersburg, 2013.
    Published
  51. Gomes I; Arinto P; Costa-Pinheiro P; Santos, C. R.; Jerónimo C; Maia, C. "Expression and regulation of STEAP1 and STEAP1B in prostate cell lines through mRNA and protein stability and epigenetic mechanisms". Paper presented in 13th Young Scientists Forum (YSF)/38th FEBS Congress, St Petersburg, 2013.
    Published
  52. Mamede, A. C.; Laranjo, M.; Moreira S; Carvalho, M. J.; Abrantes, A. M.; Pires AS; Casalta-Lopes JE; Maia CJ; Botelho, M. F.. "Effects of amniotic membrane proteins on mitochondrial activity, protein synthesis, cell viability and DNA of prostate cancer cell lines: preliminary results". Paper presented in European Cancer Congress (ECCO17 - ESMO38 - ESTRO32), Amsterdam, 2013.
    Published
  53. Mamede, A. C.; Abrantes, A. M.; Pedrosa L; Pires AS; Maia CJ; Botelho, M. F.. "Antiproliferative effect of cisplatin, doxorubicin and epirubicin in two prostate cancer cell lines". Paper presented in International Congress on Targeted Anticancer Therapies, Amsterdam, 2012.
    Published
  54. Mamede, A. C.; Abrantes, A. M.; Pedrosa L; Teixo RJ; Pires AS; Gonçalves AC; Sarmento-Ribeiro AB; Maia CJ; Botelho, M. F.. "18F-FDG and 18F-CHO: Potential tools to explore the bioenergetics needs of prostate cancer?". Paper presented in Actualizações em Oncologia, Coimbra, 2012.
    Published
  55. Marques R.; Vaz CV; Peres CG; Gomes I; Santos, C. R.; Maia CJ; Socorro, S.. "Effect of androgens on the expression of Ca2+-binding protein, regucalcin, and Ca2+-channels in MCF-7 cells.". Paper presented in 22nd Congress of European Association for Cancer Research, Barcelona, 2012.
    Published
  56. Vaz CV; Marques R.; Maia CJ; Alves M; Cavaco JE; Oliveira PF; Socorro S. "Expression of apoptosis and cell-cycle regulators in rat prostate overexpressing regucalcin". Paper presented in 22nd Congress of European Association for Cancer Research, Barcelona, 2012.
    Published
  57. I Gomes; P Arinto; CR Santos; C Lopes; CJ Maia. "Regulation of STEAP1 expression in prostate by sex steroid hormones". Paper presented in 22nd Congress of European Association for Cancer Research, Barcelona, 2012.
    Published
  58. C Maia; CV Vaz; CG Peres; CRA Santos; S Socorro. "Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?". Paper presented in The 16th ICHSCR (International Charles Heidelberger Symposium on Cancer Research), Coimbra, 2010.
    Published
  59. I Gomes; CRA Santos; S Socorro; C Lopes; CJ Maia. "STEAP1 expression in prostate cancer and its regulation by androgens". Paper presented in The 16th ICHSCR (International Charles Heidelberger Symposium on Cancer Research), Coimbra, 2010.
    Published
  60. F Silva; O Lourenço; CJ Maia; JA Queiroz; FC Domingues. "The use of multi-parameter flow cytometry to study the induction strategy impact in plasmid DNA production". Paper presented in 8th ESBES (European Symposium on Biochemical Engineering Science), Bologna, 2010.
    Published
  61. Tralhão JG; Abrantes AM; Mamede AC; Tavares SD; Gonçalves AC; Brito AF; Cardoso D; et al. "Impact of splenic artery ligation after major hepatectomy on hepatocellular function or viability". Paper presented in EANM'10 - Annual Congress of the European Association of Nuclear Medicine, Viena, 2010.
    Published
  62. CJ Maia; CRA Santos; F Schmitt; S Socorro. "SMP30 is expressed in rat mammary gland and down-regulated by 17 beta-estradiol". Paper presented in 9th European Congress of Endocrinology, Budapest, 2007.
    Published
Journal article
  1. Duarte, Filipa; Feijó, Mariana; Luís, Ângelo; Socorro, Sílvia; Maia, Cláudio J.; Correia, Sara. "Propolis Protects GC-1spg Spermatogonial Cells against Tert-Butyl Hydroperoxide-Induced Oxidative Damage". International Journal of Molecular Sciences 25 1 (2024): 614. http://dx.doi.org/10.3390/ijms25010614.
    Open access • 10.3390/ijms25010614
  2. Rocha, Sandra M.; Santos, Fátima M.; Socorro, Sílvia; Passarinha, Luís A.; Maia, Cláudio J.. "Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1870 7 (2023): 119522. http://dx.doi.org/10.1016/j.bbamcr.2023.119522.
    Open access • 10.1016/j.bbamcr.2023.119522
  3. Mateus, Cristiana; Maia, Cláudio J.; Domingues, Fernanda; Bücker, Roland; Oleastro, Mónica; Ferreira, Susana. "Evaluation of Bile Salts on the Survival and Modulation of Virulence of Aliarcobacter butzleri". Antibiotics 12 9 (2023): 1387. http://dx.doi.org/10.3390/antibiotics12091387.
    Open access • Published • 10.3390/antibiotics12091387
  4. Coelho, Rafaella S.; Rocha, Sandra M.; Maia, Cláudio J.. "Combined Therapies with Taxane-Based Chemotherapeutic Drugs in Prostate Cancer: Novel Insights and Future Directions". BioChem 3 3 (2023): 118-141. http://dx.doi.org/10.3390/biochem3030009.
    Open access • Published • 10.3390/biochem3030009
  5. Carvalho, Margarida; Gomes, Rui M.; Moreira Rocha, Sandra; Barroca-Ferreira, Jorge; Maia, Claudio J.; Guillade, Lucía; Correa-Duarte, Miguel A.; Passarinha, Luís A.; Moreira, Felismina T.C.. "Development of a novel electrochemical biosensor based on plastic antibodies for detection of STEAP1 biomarker in cancer". Bioelectrochemistry 152 (2023): 108461. http://dx.doi.org/10.1016/j.bioelechem.2023.108461.
    Published • 10.1016/j.bioelechem.2023.108461
  6. Rocha, Sandra M.; Nascimento, Daniel; Coelho, Rafaella S.; Cardoso, Ana Margarida; Passarinha, Luís A.; Socorro, Sílvia; Maia, Cláudio J.. "STEAP1 Knockdown Decreases the Sensitivity of Prostate Cancer Cells to Paclitaxel, Docetaxel and Cabazitaxel". International Journal of Molecular Sciences 24 7 (2023): 6643. http://dx.doi.org/10.3390/ijms24076643.
    Open access • Published • 10.3390/ijms24076643
  7. Rocha, S.M.; Nascimento, D.; Cardoso, A.M.; Passarinha, L.; Socorro, S.; Maia, C.J.. "STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide". Molecular medicine reports 27 2 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85146560467&partnerID=MN8TOARS.
    10.3892/mmr.2023.12939
  8. J Barroca-Ferreira; AM Gonçalves; MFA Santos; T Santos-Silva; CJ Maia; LA Passarinha. "A chromatographic network for the purification of detergent-solubilized six-transmembrane epithelial antigen of the prostate 1 from Komagataella pastoris mini-bioreactor lysates". Journal of Chromatography A (2022): https://doi.org/10.1016/j.chroma.2022.463576.
    10.1016/j.chroma.2022.463576
  9. Joana Feiteiro; Sandra M. Rocha; Melissa Mariana; Cláudio J. Maia; Elisa Cairrao. "Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation". Toxics (2022): https://doi.org/10.3390/toxics10090529.
    10.3390/toxics10090529
  10. Andreia P Alves; Sandra M Rocha; Ana C Mamede; Patrícia C Braga; Marco G Alves; Pedro F Oliveira; Filomena M Botelho; Cláudio J Maia. "Differential response of hepatocellular carcinoma glycolytic metabolism and oxidative stress markers after exposure to human amniotic membrane proteins". Molecular Biology Reports (2022): https://doi.org/10.1007/s11033-022-07598-5.
    10.1007/s11033-022-07598-5
  11. Sandra M. Rocha; Sílvia Socorro; Luís A. Passarinha; Cláudio J. Maia. "Comprehensive Landscape of STEAP Family Members Expression in Human Cancers: Unraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysis". Data 7 5 (2022): 64-64. https://doi.org/10.3390/data7050064.
    10.3390/data7050064
  12. Feiteiro, J.; Rocha, S.M.; Mariana, M.; Maia, C.J.; Cairrão, E.. "Pathways involved in the human vascular Tetrabromobisphenol A response: Calcium and potassium channels and nitric oxide donors". Toxicology 470 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85126657862&partnerID=MN8TOARS.
    10.1016/j.tox.2022.153158
  13. Sandra Rocha; Inês Sousa; Inês M. Gomes; Patrícia Arinto; Pedro Costa-Pinheiro; Eduarda Coutinho; Cecília R A Santos; et al. Corresponding author: Maia CJ. "Promoter Demethylation Upregulates STEAP1 Gene Expression in Human Prostate Cancer: In Vitro and In Silico Analysis". Life (2021): https://www.mdpi.com/2075-1729/11/11/1251.
    10.3390/life11111251
  14. Roberta V. L. Martins; Ana M. S. Silva; Ana Paula Duarte; Sílvia Socorro; Sara Correia; Cláudio J. Maia. "Natural Products as Protective Agents for Male Fertility". BioChem 1 3 (2021): 122-147. https://doi.org/10.3390/biochem1030011.
    10.3390/biochem1030011
  15. Jorge Barroca-Ferreira; Pedro Cruz-Vicente; Marino F. A. Santos; Sandra M. Rocha; Teresa Santos-Silva; Cláudio J. Maia; Luís A. Passarinha. "Enhanced Stability of Detergent-Free Human Native STEAP1 Protein from Neoplastic Prostate Cancer Cells upon an Innovative Isolation Procedure". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms221810012.
    10.3390/ijms221810012
  16. Margarida Lorigo; Carla Quintaneiro; Cláudio J. Maia; Luiza Breitenfeld; Elisa Cairrao. "UV-B filter octylmethoxycinnamate impaired the main vasorelaxant mechanism of human umbilical artery". Chemosphere 277 (2021): 130302-130302. https://doi.org/10.1016/j.chemosphere.2021.130302.
    10.1016/j.chemosphere.2021.130302
  17. Eusébio, D.; Almeida, A.M.; Alves, J.M.; Maia, C.J.; Queiroz, J.A.; Sousa, F.; Sousa, Â.. "The Performance of Minicircle DNA Versus Parental Plasmid in p53 Gene Delivery into HPV-18-Infected Cervical Cancer Cells". Nucleic Acid Therapeutics 31 1 (2021): 82-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100970797&partnerID=MN8TOARS.
    10.1089/nat.2020.0904
  18. Silva, A.M.S.; Socorro, S.; Hurtado de Llera, A.; Vaz, C.V.; Correia, S.; Maia, C.J.. "Overexpression of regucalcin mitigates the ageing-related changes in oxidative stress and sperm quality". Theriogenology 157 (2020): 472-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090216074&partnerID=MN8TOARS.
    10.1016/j.theriogenology.2020.08.028
  19. Silva, Ana M. S.; Socorro, Silvia; Hurtado de Llera, Ana; Vaz, Catia V.; Correia, Sara; Maia, Claudio J.. "Overexpression of regucalcin mitigates the ageing-related changes in oxidative stress and sperm quality". Theriogenology (2020): https://publons.com/publon/38731266/.
    10.1016/J.THERIOGENOLOGY.2020.08.028
  20. Azevedo, R.; Oliveira, N.; Maia, C.; Verde, I.; Verde, I. "Effects of di(2-etilhexil) phthalate on human umbilical artery". Chemosphere 228 (2019): 278-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065067495&partnerID=MN8TOARS.
    10.1016/j.chemosphere.2019.04.128
  21. Alves, A.P.; Mamede, A.C.; Alves, M.G.; Oliveira, P.F.; Rocha, S.M.; Botelho, M.F.; Maia, C.J.. "Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?". Current Cancer Drug Targets 19 1 (2019): 26-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048543648&partnerID=MN8TOARS.
    10.2174/1568009618666180430144441
  22. Inês Margarida Gomes; Sandra Moreira Rocha; Carlos Gaspar; Maria Inês Alvelos; Cecília Reis Santos; Sílvia Socorro; Cláudio Jorge Maia. "Knockdown of STEAP1 inhibits cell growth and induces apoptosis in LNCaP prostate cancer cells counteracting the effect of androgens". Medical Oncology 35 3 (2018): https://doi.org/10.1007/s12032-018-1100-0.
    10.1007/s12032-018-1100-0
  23. Barroca-Ferreira, J.; Pais, J.P.; Santos, M.M.; Goncalves, A.M.; Gomes, I.M.; Sousa, I.; Rocha, S.M.; Passarinha, L.A.; Maia, C.J.. "Targeting STEAP1 Protein in Human Cancer: Current Trends and Future Challenges". Current Cancer Drug Targets 18 3 (2018): 222-230.
    Published • 10.2174/1568009617666170427103732
  24. Laranjeira, P.; Duque, M.; Vojtek, M.; Inácio, M.J.; Silva, I.; Mamede, A.C.; Laranjo, M.; et al. "Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells". Cell and Tissue Research 373 2 (2018): 459-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044466992&partnerID=MN8TOARS.
    10.1007/s00441-018-2822-1
  25. Serralheiro, P.; Novais, A.; Cairrão, E.; Maia, C.; Costa Almeida, C.M.; Verde, I.. "Variability of MMP/TIMP and TGF-ß1 receptors throughout the clinical progression of chronic venous disease". International Journal of Molecular Sciences 19 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85039712738&partnerID=MN8TOARS.
    10.3390/ijms19010006
  26. Figueira, M.I.; Cardoso, H.J.; Correia, S.; Maia, C.J.; Socorro, S.. "The stem cell factor (SCF)/c-KIT system in carcinogenesis of reproductive tissues: What does the hormonal regulation tell us?". Cancer Letters 405 (2017): 10-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026443086&partnerID=MN8TOARS.
    10.1016/j.canlet.2017.07.017
  27. Serralheiro, P.; Cairrão, E.; Maia, C.J.; João, M.; Almeida, C.M.C.; Verde, I.. "Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency". Phlebology 32 5 (2017): 334-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019685841&partnerID=MN8TOARS.
    10.1177/0268355516655067
  28. Cláudio Jorge Maia Baptista; Sandra Moreira Rocha; Sílvia Socorro; Fernando Schmitt; Cecília Reis Santos. "Oligodenylate synthetase 1 (OAS1) expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones". Advances in Modern Oncology Research 2 1 (2016): https://doi.org/10.18282%2Famor.v2.i1.70.
    10.18282/amor.v2.i1.70
  29. Vaz, C.V.; Correia, S.; Cardoso, H.J.; Figueira, M.I.; Marques, R.; Maia, C.J.; Socorro, S.. "The emerging role of regucalcin as a tumor suppressor: Facts and views". Current Molecular Medicine 16 7 (2016): 607-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989246357&partnerID=MN8TOARS.
    10.2174/1566524016666160714124550
  30. Vaz, C.V.; Marques, R.; Cardoso, H.J.; Maia, C.J.; Socorro, S.. "Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation". Transgenic Research 25 2 (2016): 139-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946811164&partnerID=MN8TOARS.
    10.1007/s11248-015-9918-0
  31. Guerra, S.; Mamede, A.C.; Carvalho, M.J.; Laranjo, M.; Tralhão, J.G.; Abrantes, A.M.; Maia, C.J.; Botelho, M.F.. "Liver diseases: what is known so far about the therapy with human amniotic membrane?". Cell and Tissue Banking 17 4 (2016): 653-663. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983551904&partnerID=MN8TOARS.
    10.1007/s10561-016-9579-0
  32. Silva, A.M.S.; Correia, S.; Casalta-Lopes, J.E.; Mamede, A.C.; Cavaco, J.E.B.; Botelho, M.F.; Socorro, S.; Maia, C.J.. "The protective effect of regucalcin against radiation-induced damage in testicular cells". Life Sciences 164 (2016): 31-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987923505&partnerID=MN8TOARS.
    10.1016/j.lfs.2016.09.003
  33. Silva, A.M.S.; Correia, S.; Socorro, S.; Maia, C.J.. "Endogenous factors in the recovery of reproductive function after testicular injury and cancer". Current Molecular Medicine 16 7 (2016): 631-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989247286&partnerID=MN8TOARS.
    10.2174/1566524016666160802150400
  34. Pereira, P.; Pedro, A.Q.; Tomás, J.; Maia, C.J.; Queiroz, J.A.; Figueiras, A.; Sousa, F.. "Advances in time course extracellular production of human pre-miR-29b from Rhodovulum sulfidophilum". Applied Microbiology and Biotechnology 100 8 (2016): 3723-3734. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957660777&partnerID=MN8TOARS.
    10.1007/s00253-016-7350-x
  35. Mamede, A.C.; Guerra, S.; Laranjo, M.; Santos, K.; Carvalho, M.J.; Carvalheiro, T.; Moura, P.; et al. "Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular Carcinoma". Pathology and Oncology Research 22 4 (2016): 689-697. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960423275&partnerID=MN8TOARS.
    10.1007/s12253-016-0053-x
  36. Vaz, C.V.; Marques, R.; Alves, M.G.; Oliveira, P.F.; Cavaco, J.E.; Maia, C.J.; Socorro, S.. "Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes". Journal of Cancer Research and Clinical Oncology 142 1 (2016): 5-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953637162&partnerID=MN8TOARS.
    10.1007/s00432-015-1992-4
  37. Figueira, M.I.; Correia, S.; Vaz, C.V.; Cardoso, H.J.; Gomes, I.M.; Marques, R.; Maia, C.J.; Socorro, S.. "Estrogens down-regulate the stem cell factor (SCF)/c-KIT system in prostate cells: Evidence of antiproliferative and proapoptotic effects". Biochemical Pharmacology 99 (2016): 73-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952638603&partnerID=MN8TOARS.
    10.1016/j.bcp.2015.11.016
  38. Cardoso, Henrique J.; Vaz, Cátia V.; Correia, Sara; Figueira, Marília I.; Marques, Ricardo; Maia, Cláudio J; Socorro, Sílvia. "Paradoxical and contradictory effects of imatinib in two cell line models of hormone-refractory prostate cancer". The Prostate 75 9 (2015): 923-935.
    Published • 10.1002/pros.22976
  39. Pedro, A. Q.; Oppolzer, D.; Bonifácio, M. J.; Maia, C. J.; Queiroz, J. A.; Passarinha, L. A.. "Evaluation of MutS and Mut+ Pichia pastoris Strains for Membrane-Bound Catechol-O-Methyltransferase Biosynthesis". Applied Biochemistry and Biotechnology 175 8 (2015): 3840-3855.
    Published • 10.1007/s12010-015-1551-0
  40. Marques, Ricardo; Peres, Carina G.; Vaz, Cátia V.; Gomes, Inês M; Figueira, Marília I.; Cairrão, Elisa; Verde, Ignacio; Maia, Cláudio J; Socorro, Sílvia. "5a-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth". Medical Oncology 32 9 (2015): 228-238.
    Published • 10.1007/s12032-015-0676-x
  41. Vaz, Cátia V.; Marques, Ricardo; Maia, Cláudio J; Socorro, Sílvia. "Aging-associated changes in oxidative stress, cell proliferation, and apoptosis are prevented in the prostate of transgenic rats overexpressing regucalcin". Translational Research 166 6 (2015): 693-705.
    Published • 10.1016/j.trsl.2015.08.009
  42. Mamede, A. C.; Guerra, S.; Laranjo, M; Carvalho, M. J.; Oliveira, R. C.; Gonçalves, A. C.; Alves, R.; et al. "Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma". Medical Oncology 32 12 (2015): 257-267.
    Published • 10.1007/s12032-015-0702-z
  43. Vaz, C.V.; Rodrigues, D.B.; Socorro, S.; Maia, C.J.. "Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells". Biochimica et Biophysica Acta - Molecular Cell Research 1853 10 (2015): 2621-2628. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939454739&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2015.07.006
  44. Marques, R.; Vaz, C.V.; Maia, C.J.; Gomes, M.; Gama, A.; Alves, G.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis". Experimental Cell Research 330 2 (2015): 325-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919789386&partnerID=MN8TOARS.
    10.1016/j.yexcr.2014.08.007
  45. Gomes, Inês M; Arinto, Patrícia; Lopes, Carlos; Santos, Cecília R; Maia, Cláudio J. "STEAP1 is overexpressed in prostate cancer and prostatic intraepithelial neoplasia lesions, and it is positively associated with Gleason score". Urologic Oncology: Seminars and Original Investigations 32 1 (2014): 53.e23-53.e29.
    Published • 10.1016/j.urolonc.2013.08.028
  46. Marques, Ricardo; Maia, Cláudio J; Vaz, Cátia; Correia, Sara; Socorro, Sílvia. "The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease". Cellular and Molecular Life Sciences 71 1 (2014): 93-111.
    Published • 10.1007/s00018-013-1323-3
  47. Mamede, Ana Catarina; Laranjo, M.; Carvalho, M. J.; Abrantes, A. M.; Pires, A. S.; Brito, A. F.; Moura, P.; Maia, C. J.; Botelho, M. F.. "Effect of Amniotic Membrane Proteins in Human Cancer Cell Lines: An Exploratory Study". The Journal of Membrane Biology 247 4 (2014): 357-360.
    Published • 10.1007/s00232-014-9642-3
  48. Gonçalves, A.M.; Pedro, A.Q.; Santos, F.M.; Martins, L.M.; Maia, C.J.; Queiroz, J.A.; Passarinha, L.A.. "Trends in Protein-Based Biosensor Assemblies for Drug Screening and Pharmaceutical Kinetic Studies". Molecules 19 8 (2014): 12461-12.
    Published • 10.3390/molecules190812461
  49. Vaz, Cátia V.; Maia, Cláudio J; Marques, Ricardo; Gomes, Inês M; Correia, Sara; Alves, Marco G.; Cavaco, José E.; Oliveira, Pedro F.; Socorro, Sílvia. "Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways". The Prostate 74 12 (2014): 1189-1198.
    Published • 10.1002/pros.22835
  50. Figueira, Marília I.; Cardoso, Henrique J.; Correia, Sara; Maia, Cláudio J; Socorro, Sílvia. "Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?". Progress in Histochemistry and Cytochemistry 49 1-3 (2014): 1-19.
    Published • 10.1016/j.proghi.2014.09.001
  51. Reis, Sofia F.; Gullón, Beatriz; Gullón, Patricia; Ferreira, Susana; Maia, Cláudio J; Alonso, José L.; Domingues, Fernanda C.; Abu-Ghannam, Nissreen. "Evaluation of the prebiotic potential of arabinoxylans from brewer’s spent grain". Applied Microbiology and Biotechnology 98 22 (2014): 9365-9373.
    Published • 10.1007/s00253-014-6009-8
  52. Gaspar, Vítor M; Maia, Cláudio J; Queiroz, João A.; Pichon, Chantal; Correia, Ilídio J; Sousa, Fani. "Improved Minicircle DNA Biosynthesis for Gene Therapy Applications". Human Gene Therapy Methods 25 2 (2014): 93-105.
    Published • 10.1089/hgtb.2013.020
  53. Gomes, I. M.; Santos, C. R.; Maia, C J. "Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms". Genes & Cancer 5(3-4) (2014): 142-151.
    Published
  54. Gomes, I.; Gaspar, C.; Alvelos, M. I.; Santos, C.; Maia, C.. "Effect of down-regulation of STEAP1 by siRNA in cell cycle and apoptosis of human LNCaP prostate cells". Febs Journal 281 (2014): 457-457. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359666803077&KeyUID=WOS:000359666803077.
  55. Gomes, I.M.; Santos, C.R.; Maia, C.J.. "Expression of steap1 and steap1b in prostate cell lines, and the putative regulation of steap1 by post-transcriptional and post-translational mechanisms". Genes and Cancer 5 3-4 (2014): 142-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938556050&partnerID=MN8TOARS.
  56. Saldanha, Paulo A; Cairrão, Elisa; Maia, Cláudio J; Verde, Ignacio. "Long- and short-term effects of androgens in human umbilical artery smooth muscle". Clinical and Experimental Pharmacology and Physiology 40 3 (2013): 181-189.
    Published • 10.1111/1440-1681.12047
  57. Gomes, Inês M; Santos, Cecília R; Socorro, Sílvia; Maia, Cláudio J. "Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells". The Prostate 73 6 (2013): 605-613.
    Published • 10.1002/pros.22601
  58. Goncalves, A. M.; Pedro, A.Q.; Maia, C.; Sousa F; Queiroz, J.A.; Passarinha, L.A.. "Pichia pastoris: A Recombinant Microfactory for Antibodies and Human Membrane Proteins". Journal of Microbiology and Biotechnology 23 5 (2013): 587-601.
    Published • 10.4014/jmb.1210.10063
  59. Mamede, A. C.; Abrantes, A. M.; Pedrosa L; Casalta-Lopes JE; Pires AS; Teixo RJ; Gonçalves AC; et al. "Beyond the limits of oxygen: effects of hypoxia in a hormone-independent prostate cancer cell line". ISRN Oncology 2013 918207 (2013): 1-8.
    Published • 10.1155/2013/918207
  60. Mamede, A. C.; Carvalho, M. J.; Abrantes, A. M.; Laranjo, M.; Maia, C. J.; Botelho, M. F.. "Amniotic membrane: from structure and functions to clinical applications". Cell and Tissue Research 349 2 (2012): 447-458. http://www.ncbi.nlm.nih.gov/pubmed/22592624.
    Published • 10.1007/s00441-012-1424-6
  61. Gomes, I. M.; Maia, C. J.; Santos, C. R.. "STEAP Proteins: From Structure to Applications in Cancer Therapy". Molecular Cancer Research 10 5 (2012): 573-587. http://www.ncbi.nlm.nih.gov/pubmed/22522456.
    Published • 10.1158/1541-7786.MCR-11-0281
  62. Martins, Rita; Maia, Cláudio J.; Queiroz, João A.; Sousa, Fani. "A new strategy for RNA isolation from eukaryotic cells using arginine affinity chromatography". Journal of Separation Science 35 22 (2012): 3217-3226. http://www.ncbi.nlm.nih.gov/pubmed/23001903.
    Published • 10.1002/jssc.201200338
  63. Vaz, Cátia V.; Alves, Marco G.; Marques, Ricardo; Moreira, Paula I.; Oliveira, Pedro F.; Maia, Cláudio J; Socorro, Sílvia. "Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile". The International Journal of Biochemistry & Cell Biology 44 11 (2012): 2077-2084.
    Published • 10.1016/j.biocel.2012.08.013
  64. Silva, Filomena; Lourenço, Olga; Maia, Cláudio; Queiroz, João A.; Domingues, Fernanda C.. "Impact of plasmid induction strategy on overall plasmid DNA yield and E. coli physiology using flow cytometry and real-time PCR". Process Biochemistry 46 1 (2011): 174-181.
    Published • 10.1016/j.procbio.2010.08.001
  65. Pedro, A.Q.; Bonifácio, M.J.; Queiroz, J.A.; Maia, C.J.; Passarinha, L.A.. "A novel prokaryotic expression system for biosynthesis of recombinant human membrane-bound catechol-O-methyltransferase". Journal of Biotechnology 156 2 (2011): 141-146.
    Published • 10.1016/j.jbiotec.2011.08.022
  66. Santos, C; Socorro, S; Maia, C. "STEAP1 (Six Transmembrane Epithelial Antigene of the Prostate 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology 14 5 (2011): 482-484.
    Published • 10.4267/2042/44760
  67. Maia, C; Socorro, S; Santos, C. "STEAP2 (six transmembrane epithelial antigen of the prostate 2)". Atlas of Genetics and Cytogenetics in Oncology and Haematology 15 2 (2011): 217-219.
    Published • 10.4267/2042/44970
  68. Silva, F.; Lourenço, O.; Maia, C.; Queiroz, J.A.; Domingues, F.C.. "Monitoring plasmid DNA induction strategies using multi-parameter flow cytometry and real-time PCR". Journal of Biotechnology 150 Supp.1 (2010): 530-531.
    Published • 10.1016/j.jbiotec.2010.09.861
  69. Maia, Cláudio; Santos, Cecília; Schmitt, Fernando; Socorro, Silvia. "Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones". Journal of Cellular Biochemistry 107 4 (2009): 667-676.
    Published • 10.1002/jcb.22158
  70. Maia, Claudio J. B.; Socorro, Silvia; Schmitt, Fernando; Santos, Cecilia R. A.; Maia, C.J.B.; Socorro, S.; Schmitt, F.; Santos, C.R.A.. "STEAP1 is over-expressed in breast cancer and down-regulated by 17 beta-estradiol in MCF-7 cells and in the rat mammary gland". Endocrine 34 1-3 (2008): 108-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-65449116921&partnerID=MN8TOARS.
    Published • 10.1007/s12020-008-9113-7
  71. Maia, C.J.B.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17ß-estradiol". Molecular and Cellular Biochemistry 311 1-2 (2008): 81-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349096904&partnerID=MN8TOARS.
    10.1007/s11010-007-9697-x
  72. Maia, C.J.B.; Socorro, S.; Schmitt, F.; Santos, C.R.A.. "Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: Effects of 17ß-estradiol on the regulation of OAS1g in both tissues". Molecular and Cellular Biochemistry 314 1-2 (2008): 113-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449097052&partnerID=MN8TOARS.
    10.1007/s11010-008-9771-z
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - Current Identification of proteins differentially expressed in STEAP1-knockdown prostate cancer cells sentitive to androgens
Supervisor
 Medicina (Master)
Universidade da Beira Interior, Portugal
2019 - Current Biointeration studies of membrane-bound catechol-O-methyltransferase polymorphic variants with commercial Parkinson’s inhibitors
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2017 - Current Unraveling the effect of STEAP1 knockdown in prostate cancer cells: from protein expression profile to clinical applications
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2021 - 2024/03 Efeito do silenciamento do gene STEAP1 em células LNCaP em resposta ao tratamento com apalutamida e paclitaxel.
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2022/09/01 - 2024/02 The role of STEAP1 in the sensitivity of C4-2B prostate cancer cells to taxane-based chemotherapy.
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2022/09/01 - 2024/02 Protective potentialities of propolis towards spermatogonial oxidative damage
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2018 - 2022/12 Structural and Functional Characterization of the Cancer-associated Epithelial Antigen STEAP1
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2018 - 2022 The implications of Flame Retardants in the development of hypertensive disorders in pregnancy
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2021 - 2021 Utilização de ferramentas biotecnológicas no estudo do cancro. Estágio de verão no CICS-UBI, 2021.
Supervisor
Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2021 - 2021 Determination of STEAP1 glycan profile: comparison between neoplastic and non-neoplastic environments. Research Exchange Program for Medical Students of International Federation of Medical Students Associations (IFMSA).
Supervisor
Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2020 - 2021 Efeito do silenciamento do gene STEAP1 em células LNCaP submetidas ao tratamento com cabazitaxel ou enzalutamida.
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2019 - 2020 Effect of STEAP1 knockdown in bicalutamide-treated LNCaP cells
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2015 - 2019 Regucalcin as one of the guardians of the male reproductive function
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2017 - 2018 Vitamin D actions in the regulation of regucalcin in human prostate cancer cells
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 Design of an one-step platform purification of STEAP1 using hydrophobic interaction chromatography
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2017 Amniotic membrane: a therapeutic option for cancer?
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal

Universidade de Coimbra, Portugal
2016 - 2017 Optimization of human STEAP1 protein biosynthesis in recombinant cells using a Placket-Burman and Central Composite Design
Co-supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 The evaluation of amniotic membrane as therapy against cancer
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Isolation and purification of STEAP1 protein fragment in Escherichia coli cells: a potential target for prostate cancer
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Biosynthesis and isolation of STEAP1 protein from Escherichia coli cells lysates
Co-supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Biosynthesis and purification of the protein STEAP1: a potential therapeutic target for prostate cancer
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Genetic and epigenetic mechanisms involved on the regulation of STEAP1 expression in LNCaP prostate cancer cell line
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Hepatocellular carcinoma therapy based on human amniotic membrane Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Genetic and epigenetic mechanisms involved in regulation of STEAP1 gene expression in LNCaP prostate cancer cells Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Biosynthesis optimization of STEAP1 protein in Pichia pastoris X33 MUT+ Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Isolation and purification of STEAP1 protein fragment in Escherichia coli cells: a potential target for prostate cancer Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2015 Role of regucalcin in breast cells proliferation and tumor development
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2015 - 2015 The protective effect of regucalcin against radiation-induced testicular damage
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2015 The protective effect of regucalcin against radiation-induced testicular damage Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Regulation of STEAP1 gene and its clinical significance in human prostate cancer
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2014 - 2014 Molecular Mechanisms of SCF/c-KIT Action Mediating Prostate Cell Proliferation
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Hormonal Regulation of SCF/c-KIT in Prostate Cancer Cells
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2012 - 2012 Regulation of STEAP1 gene and its clinical significance in human prostate cancer Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2011 - 2011 Biosynthesis, solubilization and purification of human membrane bound catechol-O-methyltransferase in Brevibacillus choshinensis cells
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2011 - 2011 Identification of genes differentially expressed in subtractive library of normal breast versus breast cancer
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2011 - 2011 Regulation of six transmembrane epithelial antigen of the prostate 1 by epigenetic mechanisms
Supervisor
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011 Regucalin regulation by calcium in prostate cells
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2011 - 2011 Regucalcin expression in human breast cancer phenotypes
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2011 - 2011 Amniotic membrane. A therapeutic option against cancer? Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2010 - 2010 Six transmembrane epithelial antigen of the prostate 1 expression in human prostate cancer and its regulation by androgens
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2010 - 2010 Effect of regucalcin on the expression of oncogenes and tumor supressor genes in prostate cell lines
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/02/04 - 2022/02/04 World Cancer Day. Mesa redonda para debater o cancro em diferentes pontos de vista na área da investigação.
Round table
 World Cancer Day
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/11/24 - 2021/11/24 Cancro: o que é e como prevenir através de um estilo de vida saudável? Palestra no Âmbito da Semana de Ciência e Tecnologia (24/11/2021).
Conference
 Semana de Ciência e Tecnologia
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Protective potentialities of propolis towards spermatogonial oxidative damage
Thesis Member
 Filipa Duarte (Master)
Universidade da Beira Interior, Portugal
2023 Treino Intervalado de Alta Intensidade em Dmt2 Revisão Aplicada ao Controlo Glicémico e Composição Corporal.
President of the jury
 Carlota Rodrigues (Master)
Universidade da Beira Interior, Portugal
2023 Diagnóstico de Osteoporose em Doentes com Espondilartrite Axial – Análise Numa Unidade de Reumatologia da Beira Interior.
President of the jury
 Diana Ferreira (Master)
2023 Osteoporose e Metabolismo Ósseo na Esclerose Sistémica Análise de Um Grupo de Doentes Numa Unidade de Reumatologia da Beira Interior.
President of the jury
 Ana Oliveira (Master)
2023 A Prevalência de Candida Spp no Centro Hospitalar da Cova da Beira.
President of the jury
 Maria Pereira (Master)
2023 Epidermólise Bolhosa Distrófica Recessiva: Abordagem às Complicações Músculo-Esqueléticas - Estudo de Caso.
President of the jury
 Lumira Semedo (Master)
2023 Contraceção de Emergência o Contexto da Atualidade.
President of the jury
 Liliana Mendes (Master)
2023 Parto Vaginal Após Cesariana: a Experiência do CHUCB.
President of the jury
 Ana Teodoro (Master)
2023 O Grande Desafio da Saúde Contemporânea. Monografia sobre Literacia em Saúde em Portugal.
President of the jury
 Ana Ferreira (Master)
2023 Estrogens and the G protein-coupled estrogen receptor in prostate cancer: angels or demons?
Thesis Member
 Marília Figueira (PhD)
2022 Ralgps2 na Proliferação e Sobrevivência de Células Tumorais Humanas de Cancro da Próstata
(Thesis) Main arguer
 Ana Roque (Master)
Universidade da Beira Interior, Portugal
2022 Identificação de Biomarcadores em Doentes com Cancro do Pulmão de Não-Pequenas Células Tratados com Imunoterapia
President of the jury
 Inês Santos (Master)
Universidade da Beira Interior, Portugal
2022 sobre a Relação entre a Atividade Física e a Microbiota Intestinal
President of the jury
 José Monteiro (Master)
Universidade da Beira Interior, Portugal
2022 Ansiedade e Depressão em Cuidados Paliativos: a Realidade de Uma Equipa Intra-Hospitalar da Região Centro do País
President of the jury
 Joana Matias (Master)
Universidade da Beira Interior, Portugal
2022 O Uso de Anti-Inflamatórios Não Esteroides Nas Lesões Musculares e Ligamentares Prós e Contras
President of the jury
 Luís Neves (Master)
Universidade da Beira Interior, Portugal
2022 Avaliação do Impacto dos Níveis de Expressão de Ralgps2 em Cancro do Pulmão e da Próstata
(Thesis) Main arguer
 Catarina Diniz (Master)
Universidade da Beira Interior, Portugal
2021 Avaliação do Impacto das Medidas de Contenção da Transmissão de Sars-Cov-2 Na Incidência de Infeções Respiratórias Na Época 2020-21.
(Thesis) Main arguer
 Carolina Afonso (Master)
Universidade da Beira Interior, Portugal
2021 Could The Perception of Risk Increase Adherence To Preventive Measures To Control The Pandemic Covid-19? A Study With Elderly People.
President of the jury
 Rafaela Gonçalves (Master)
Universidade da Beira Interior, Portugal
2021 Depression, Anxiety and Loneliness In Ageing: Dynamics of A Trio In Times of Pandemic Covid-19.
President of the jury
 Carolina Ramalho (Master)
Universidade da Beira Interior, Portugal
2021 Further Insights Into Regucalcin Actions As A Potential Tumour Suppressor In Human Prostate.
(Thesis) Main arguer
 Lara Fonseca (Master)
Universidade da Beira Interior, Portugal
2020 Regucalcin as one of the guardians of the male reproductive function
Supervisor
 Ana Silva (PhD)
Universidade da Beira Interior, Portugal
2019 Prostate cancer cells metabolismo on the interplay of androgenic regulation and metabolic environment.
Thesis Member
 Henrique Cardoso (PhD)
Universidade da Beira Interior, Portugal
2018 Suscetibilidade genética ao cancro da tiroide: variantes genómicas nas vias de metabolismo da vitamina D Isabel Carvalho (Master)
Universidade da Beira Interior, Portugal
2018 DNA minicircular mutagénico com potencial ação terapêutica no cancro do colo do útero Dalinda Eusébio (Master)
Universidade da Beira Interior, Portugal
2018 The Effect of plant extracts in human prostate cells: implications in cancer Sara Gonçalves (Master)
Universidade da Beira Interior, Portugal
2016 Isolation and purification of STEAP1 protein fragment in Escherichia coli cells: a potential target for prostate cancer Jorge Ferreira (Master)
Universidade da Beira Interior, Portugal
2016 A Síndrome de Burnout Em Enfermeiros e Médicos da Unidade Local de Saúde de Castelo Branco: Prevalência e Efeitos Associados Ana Esteves (Master)
Universidade da Beira Interior, Portugal
2015 Cyto-Histological Correlation of The “Follicular Lesion of Undetermined Significance” Category According To The Bethesda Classification System of Thyroid Aspirative Cytology Pedro Aresta (Master)
Universidade da Beira Interior, Portugal
2015 Neuroproteção: Abordagem Na Doença de Parkinson Luís Tavares (Master)
Universidade da Beira Interior, Portugal
2015 Desenvolvimentos Na Administração Intranasal de Antipsicóticos: Aspetos Farmacêuticos, Farmacocinéticos e Farmacodinâmicos Experiência Profissionalizante Na Vertente de Farmácia Comunitária e Investigação Rui Santos (Master)
Universidade da Beira Interior, Portugal
2015 Esclerose Múltipla: Fatores Nutricionais e Fisiopatologia Débora Campos (Master)
Universidade da Beira Interior, Portugal
2015 Ecografia das Glândulas Salivares Major Na Avaliação e Seguimento dos Doentes Com Síndrome de Sjögren Primária Catarina Roteia (Master)
Universidade da Beira Interior, Portugal
2015 Papel da Microbiota Nas Doenças Digestivas Gisela Andrade (Master)
Universidade da Beira Interior, Portugal
2015 Follow-Up de Pacemakers No Chcb Deteção e Correção de Disfunções/Disritmias Henrique Santos (Master)
Universidade da Beira Interior, Portugal
2015 Recorrência da Infeção Por Clostridium Difficile: Será O Transplante Fecal Uma Hipótese A Considerar? Luís Alves (Master)
Universidade da Beira Interior, Portugal
2014 Regulation of STEAP1 gene and its clinical significance in human prostate cancer
Supervisor
 Inês Margarida Gomes (PhD)
Universidade da Beira Interior, Portugal
2014 Antidiabéticos Orais: Perfil de Utilização, Efeitos Secundários e Interações Medicamentosas Experiência Profissionalizante Na Vertente de Farmácia Comunitária e Investigação Davide Esteves (Master)
Universidade da Beira Interior, Portugal
2014 Caracterização do Consumo de Antiasmáticos e Broncodilatadores Em Ambulatório No Concelho da Covilhã Experiência Profissionalizante Na Vertente de Farmácia Comunitária, Hospitalar e Investigação Tiago Dias (Master)
Universidade da Beira Interior, Portugal
2013 Biorecognition by amino acid-based affinity chromatography for RNA purification. Ana Rita Martins (PhD)
2013 Efeito da testosterona na compartimentação do cGMP a nível vascular Joana Feiteiro (Master)
Universidade da Beira Interior, Portugal
2012 MicroRNAs: deteção precoce no cancro colo-retal; Projecto de licenciatura em Ciências Biomédicas da Universidade da Beira Interior Ana Martins (Other)
Universidade da Beira Interior, Portugal
2012 Hipóxia: um fator chave na regulação do cancro da próstata? Projeto do Mestrado Integrado em Engenharia Biomédica da Universidade de Coimbra Liliana Pedrosa (Master)
Universidade de Coimbra, Portugal
2012 Epigenetic regulation of microRNAs in prostate cancer. Projeto do Mestrado em Oncologia do Instituto de Ciências Biomédicas Abel Salazar João Barbosa Martins (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 Identification of genetic mutations in patients with familial central diabetes insipidus. Projeto do Mestrado em Bioquímica da Universidade da Beira Interior Ângela Francisco (Master)
Universidade da Beira Interior, Portugal
2012 Efeitos genómicos da di-hidrotestosterona nas células vasculares do músculo liso humano Paulo Saldanha (Master)
Universidade da Beira Interior, Portugal

Association member

Society Organization name Role
2000/01 - Current Associação Nacional de Bioquímicos (ANBIOQ)

Committee member

Activity description
Role 		Institution / Organization
2021/11 - Current Comissão Executiva do Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior (CICS-UBI)
Member
 Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2018 - Current Member of ORBEA (Animal Welfare Body and Ethics Body) from CICS-UBI Universidade da Beira Interior, Portugal
2012/06 - Current Coordenador do 1º ano do curso de Mestrado Integrado em Medicina
Coordinator
 Universidade da Beira Interior, Portugal
2012/04 - 2017 Membro responsável pela organização e gestão do Biotério da Universidade da Beira Interior
Member
 Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2010/03 - 2012/02 Membro responsável pela formação de jovens investigadores
Member
 Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current Advanced course "From gene to protein: a practical approach". Biomedicina (Doutoramento) Universidade da Beira Interior, Portugal
2018 - Current Bases Celulares e Moleculares da Medicina Mestrado Integrado em Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2011/09 - Current Biologia Celular e Molecular Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2011/02 - Current Engenharia Genética Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2008/01 - Current Biologia Celular e Molecular Mestradro integrado em C. Farmacêuticas e Licenciatura em C. Biomédicas (Outros) Universidade da Beira Interior, Portugal
2008/01 - Current Anatomia e Fisiologia Humana II: Sistema Urogenital e Endócrino Mestrado integrado em C. Farmacêuticas (Outros) Universidade da Beira Interior, Portugal
2018 - 2019 Oncobiologia Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2008/01 - 2019 Corpo Humano II: Bloco Nefro-Urinário e Reprodutor Mestrado integrado em Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2008/01 - 2017/12 Corpo Humano I: Biologia Celular e Molecular Mestrado integrado em Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2011 - 2011 Formação em Real Time PCR Outra (Curso médio) Centro de Investigação em Ciências da Saúde (CICS), Portugal
2011 - 2011 Formação em Imunohistoquímica Outra (Curso médio) Centro de Investigação em Ciências da Saúde (CICS), Portugal
2008/01 - 2011 Biologia Celular e Molecular Bioquímica; C. Farmacêuticas; C. Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2008/01 - 2010/07 Genética Bioquímica e Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2010 - 2010 Formação de Jovens Investigadores Outra (Curso médio) Centro de Investigação em Ciências da Saúde (CICS), Portugal
2009 - 2009 Seminário no âmbito da disciplina "Perspectivas em Bioquímica" do 1º ciclo do curso de Bioquímica Outra (Curso médio) Departamento de Química, Portugal
2008/01 - 2008/12 Biologia Molecular Aplicada Mestrado em Ciências Biomédicas (Mestrado) Universidade da Beira Interior, Portugal
2006/09 - 2007/11 Biologia Celular e Molecular (Aulas Práticas) Bioquímica; C. Farmacêuticas; C. Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/01 - 2024 XV Edição do BeInMed- Beira Interior Medical Meeting. 10th-14th january 2024, Covilhã, Portugal. (Coordinator of preclinical competition).
Coordinator
 MedUBI, Portugal
2023/02/12 - 2023/02/15 IV International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Challenges from Research to Clinic. (Scientific Committee)
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/01 - 2023/01 XIV Edição do BeInMed- Beira Interior Medical Meeting. 13rd-14th january 2023, Covilhã, Portugal. (Coordinator of preclinical competition).
Coordinator
 MedUBI, Portugal
2022 - 2022 XIII Edição do BeInMed – Beira Interior Medical Meeting. 10-13th february 2022, Covilhã, Portugal. (Coordinator of preclinical competition).
Coordinator
 MedUBI, Portugal
2019 - 2019 XIV Annual CICS-UBI Symposium, 4-5th July 2019, Covilhã, Portugal. (Awards Committee)
Evaluator
 Universidade da Beira Interior, Portugal
2019 - 2019 III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship:,Trends in Aging and Cancer, 14-15th November 2019, Covilhã, Portugal. (Scientific Committee).
Evaluator
 Centro de Investigação em Ciências da Saúde (CICS), Portugal
2017 - 2017 XII Annual CICS-UBI Symposium, 2017, Covilhã, Portugal. (Awards Committee)
Evaluator
 Universidade da Beira Interior, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/10/28 Divulgação de investigação na área do cancro da próstata; Rúbrica “90 segundos de Ciência”, Episódio 1184 Rúbrica “90 segundos de Ciência”, Episódio 1184
2021/10/25 Divulgação do projeto CICS4COVID- Testar, Rastrear, e Inovar no Diagnóstico da COVID-19. Ensino Magazine (25/10/2021). Ensino Magazine

Interview (tv / radio show)

Program Topic
2021/10/12 - 2021/10/12 Noticiário da Rádio Cova da Beira. Divulgação do projeto CICS4COVID- Testar, Rastrear, e Inovar no Diagnóstico da COVID-19.
2021 - 2021 Jornal Nacional da TVI (17/10/2021). Divulgação do projeto CICS4COVID- Testar, Rastrear, e Inovar no Diagnóstico da COVID-19.

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Current Medicinal Chemistry (0929-8673) Bentham Science Publishers
2021 - Current Computational and Structural Biotechnology Journal (ISSN: 2001-0370) Elsevier
2021 - Current Gene Reports (2452-0144) Elsevier
2021 - Current histology and histopathology (0213-3911)
2021 - Current Life (2075-1729) MDPI
2020 - Current Molecules (1420-3049) MDPI
2020 - Current BioMed Research International Hindawi
2020 - Current Journal of International Medical Research SAGE Publishing
2019 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2019 - Current Cells (2073-4409) MDPI
2019 - Current Medical Science Monitor International Scientific Information
2019 - Current Anais da Academia Brasileira de Ciencias SciELO
2019 - Current Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Elsevier
2019 - Current Biomedicine & Pharmacotherapy Elsevier
2019 - Current Diagnostics MDPI
2019 - Current International Journal of Nanomedicine Dove Medical Press Ltd.
2019 - Current Nutrients MDPI
2019 - Current Oxidative Medicine and Cellular Longevity Hindawi
2019 - Current Reproductive Biology Elsevier
2018 - Current Cancers (2072-6694) MDPI
2018 - Current Journal of Clinical Medicine (2077-0383)
2018 - Current Biomolecules (2218-273X) MDPI
2018 - Current Cancer Letters Elsevier
2018 - Current OncoTargets and Therapy Dove Medical Press Ltd.
2018 - Current Scientific Reports Nature Publishing Group
2017 - Current Anti-Cancer Agents in Medicinal Chemistry Bentham Science Publishers
2017 - Current Tumor Biology SAGE Publishing
2017 - Current Cancer Biology and Medicine Chinese Anti-Cancer Association
2017 - Current Reproduction, Fertility and Development CSIRO Publishing
2016 - Current Urologic Oncology: Seminars and Original Investigations Elsevier
2016 - Current Cell Biology International Wiley
2016 - Current Molecular and Cellular Endocrinology Elsevier
2016 - Current AIMS Molecular Science AIMS Press
2016 - Current Journal of Bone Oncology Elsevier
2016 - Current Letters in Drug Design & Discovery Bentham Science Publishers
2016 - Current Plos One Public Library of Science
2016 - Current SpringerPlus Springer Nature
2015 - Current BMJ Open BMJ Publishing Group
2015 - Current International Journal of Urology Wiley
2015 - Current Journal of Applied Biomaterials & Functional Materials SAGE Publishing
2014 - Current Cancer Management and Research Dove Medical Press Ltd.
2014 - Current World Journal of Clinical Oncology
2014 - Current Journal of Nuclear Medicine Society of Nuclear Medicine and Molecular Imaging

Other jury / evaluation

Activity description Institution / Organization
2023/06 - Current Membro do júri para atribuição de Bolsas de incentivo “UBI Bolsas Impulso Adultos” no âmbito da formação não conferente de grau, intitulada “Formação para Investigadores Envolvidos na Realização de Procedimentos em Animais de Laboratório”. Universidade da Beira Interior, Portugal
2022 - 2022 Bolsa de investigação (BI_4), no âmbito do projecto de investigação intitulado ¿CICS4COVID - Testar, Rastrear, e inovar no Diagnóstico da COVID-19¿ CENTRO-01-0145-FEDER-072541); Cofinanciado na sua componente de Fundo Europeu de Desenvolvimento Regional (FEDER) através do Programa Operacional Regional do Centro, e na sua componente nacional pela Fundação para a Ciência e a Tecnologia, I. P. (Presidente) Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2022 - 2022 Bolsa de investigação (BI_5), no âmbito do projecto de investigação intitulado ¿CICS4COVID - Testar, Rastrear, e inovar no Diagnóstico da COVID-19¿ CENTRO-01-0145-FEDER-072541); Cofinanciado na sua componente de Fundo Europeu de Desenvolvimento Regional (FEDER) através do Programa Operacional Regional do Centro, e na sua componente nacional pela Fundação para a Ciência e a Tecnologia, I. P. (Presidente) Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2022 - 2022 Bolsa de investigação (BI_6), no âmbito do projecto de investigação intitulado “CICS4COVID - Testar, Rastrear, e inovar no Diagnóstico da COVID-19” (CENTRO-01-0145-FEDER-072541); Cofinanciado na sua componente de Fundo Europeu de Desenvolvimento Regional (FEDER) através do Programa Operacional Regional do Centro, e na sua componente nacional pela Fundação para a Ciência e a Tecnologia, I. P., 2021. (Presidente). Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior, Portugal
2018 - 2018 Contratação de doutorado(a) para o exercício de atividades de investigação científica na área de Biologia da Reprodução a decorrer no Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior. (Vogal) Universidade da Beira Interior, Portugal
2018 - 2018 Contratação de doutorado(a) para o exercício de atividades de investigação científica na área de Oncobiologia a decorrer no Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior no âmbito do projeto “Fatores extrínsecos na modulação do metabolismo da próstata: aplicação na prevenção, diagnóstico e tratamento do cancro”- ProMETAB (POCI-01-0145-FEDER-029114). (Vogal) Universidade da Beira Interior, Portugal
2017 - 2017 Membro o júri do 25º concurso para jovens cientistas. 11ª Mostra Nacional no Centro de Congressos da Alfândega do Porto, 1 a 3 de julho 2017, Porto, Portugal. Ciência Viva, Portugal
2015 - 2015 Bolsa de investigação (BI), Ref. HIB-2-003, no âmbito do projecto de investigação intitulado “Hormonal and Inflammatory basis of age-related diseases” (CENTRO-07-ST24-FEDER-002015); Financiado pelo QREN (Programa “Mais Centro”). (Vogal) Universidade da Beira Interior, Portugal
2015 - 2015 Bolsa de investigação (BI), Ref. HIB-2-005, no âmbito do projecto de investigação intitulado “Hormonal and Inflammatory basis of age-related diseases” (CENTRO-07-ST24-FEDER-002015); Financiado pelo QREN (Programa “Mais Centro”). (Vogal) Universidade da Beira Interior, Portugal
2015 - 2015 Bolsa de investigação (BI), Ref. HIB-2-007, no âmbito do projecto de investigação intitulado “Hormonal and Inflammatory basis of age-related diseases” (CENTRO-07-ST24-FEDER-002015); Financiado pelo QREN (Programa “Mais Centro”). (Vogal) Universidade da Beira Interior, Portugal
2015 - 2015 Influência da obesidade na agressividade do carcinoma da próstata: papel do tecido adiposo periprostático e microambiente local na proliferação e transição epitélio-mesenquimatosa no adenocarcinoma prostático; Apreciação de projeto de doutoramento em Ciências da Saúde da Universidade de Coimbra. Universidade de Coimbra, Portugal
2013 - 2013 Bolsa de investigação (BI) no âmbito do projeto de investigação intitulado "Biosynthesis, purification and biointeraction of human soluble catechol-O-methyltransferase with Parkinson´s inhibitors". Founded by FCT (EXPL/BBB-BQB/0960/2012). (Vogal) Universidade da Beira Interior, Portugal
2010 - 2010 Bolsa de integração à investigação (BII) no âmbito do projecto intitulado “Characterization and development of new materials with antimycotic activity” (BII2009/6/CICS), financiado pela FCT. (Vogal) Universidade da Beira Interior, Portugal
2010 - 2010 Bolsa de integração à investigação (BII) no âmbito do projecto intitulado “Regucalcin: a new target gene in prostate cancer?” (BII2009/2/CICS), financiado pela FCT. (Vogal) Universidade da Beira Interior, Portugal
2010 - 2010 - Bolsa de investigação (BI) no âmbito do projecto de investigação intitulado “Genética molecular e genómica funcional das deficiências de hormonas hipofisárias” (PTDC/SAU/-GMG/098419/2008), financiado pela FCT. (Vogal suplente) Universidade da Beira Interior, Portugal
2009 - 2009 Bolsa de investigação (BI) no âmbito do projecto intitulado “Fabrico de scaffolds com factores de crescimento para regeneração de tecidos ósseos por impressão 3D” (PTDC/EME-TME/103375/2008), financiado pela FCT. (Vogal) Universidade da Beira Interior, Portugal
Distinctions

Award

2018 Best "tutor" award in the first year of Medicine Integrated Master; Elected by students
2017 Best "Bloco-Cell Biology" award in the first year of Medicine Integrated Master; Elected by students
2016 Best "Bloco-Cell Biology" award in the first year of Medicine Integrated Master; Elected by students
2014 Best "tutor" award in the first year of Medicine Integrated Master; Elected by students
2012 Best poster presentation award in "V jornadas sobre tecnologia e saúde"
Instituto Politécnico da Guarda, Portugal
2003 School award for completing a Biochemistry degree with the best final grade
Universidade da Beira Interior, Portugal
2003 PhD Fellow
Fundação para a Ciência e a Tecnologia, Portugal