Elva Bonifácio Andrade (511C-11AA-7980)

Curriculum Vitae

Elva Bonifácio Andrade

Elva Bonifácio Andrade graduated in biochemistry (University of Porto [UP]) in 2005 and obtained her Ph.D. in biomedical sciences at the Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP) in 2013. Her PhD work focused on the characterization of the innate immune mechanisms leading to neonatal susceptibility to Group B Streptococcus (GBS) infections. Part of her PhD work focused on characterising the innate immune mechanisms leading to neonatal susceptibility to Group B Streptococcus (GBS) infections. Part of her PhD work was distinguished with the 'Excellence in Immunology Mario Arala Chaves Award' by the Portuguese Society for Immunology, in 2013. She was a postdoc at ICBAS-UP, before being awarded a highly competitive Researcher position within the scope of the Stimulus of Scientific Employment, individual support from FCT, in 2019. During her postdoctoral studies, she developed a mouse model that recapitulates GBS neonatal infection pathogenesis, with features similar to those described in humans (Andrade et al., 2018. Nature Communications). This work gave her the 'SPI Paper Award 2019', by the Portuguese Society for Immunology. Since 2020, she has been a research scientist at i3S (Instituto de Investigação e Inovação em Saúde, University of Porto), where she established a new line of research focused on understanding the complex neuroimmune interactions during GBS disease, aiming at promoting neonatal and child well-being, by developing new therapeutic and neuroprotective strategies. She is currently supervising two PhD student and one Master student, and co-supervising one PhD student, while had also successfully supervised/co-supervised 16 BSc and 7 MSc students. She was an evaluator of 4 BSc Degrees, 5 MSc Dissertations, 1 PhD seminar, and 3 PhD Thesis. As principal investigator, she has recently been awarded one CEEC from FCT as well as two projects as PI/Co-PI from FCT. Over the last 5 years, she also taught Immunology at the School of Health, Polytechnic Institute of Porto (at both BSc and MSc levels). Recently, she started teaching Microbiology and Immunology at ICBAS-UP. She was involved in the scientific and organising committees of scientific meetings and participated in several outreach activities with ICBAS-UP and i3S to increase public awareness of Science through school programs.

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Identification

Personal identification

Full name: Elva Bonifácio Andrade

Citation names

Bonifácio Andrade, Elva

Author identifiers

Ciência ID: 511C-11AA-7980
ORCID iD: 0000-0002-1941-580X

Addresses

Rua Alfredo Allen, 208 , 4200-135, Porto, Porto, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Health Sciences - Infectious Diseases
Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2013/09/02 Concluded	Ciências Biomédicas (Doutoramento) Major in Sem especialidade Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Study of the mechanisms involved in neonatal sepsis and meningites by Group B Streptococcus" (THESIS/DISSERTATION)	Aprovado por Unanimidade com Distinção e Louvor
2005/12/16 Concluded	Bioquímica (Licenciatura) Major in Bioquímica Aplicada Universidade do Porto Faculdade de Ciências, Portugal "Immunoprotection assays against dental caries induced by Streptococcus sobrinus using the virulence-associated immunomodulatory protein Enolase as a target antigen" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2020 - Current	Contracted Researcher (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/07/01 - 2019/12/15	Postdoc (Research)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

2014/10/01 - 2015/06/30	Postdoc (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

2014/01/01 - 2014/09/30	Postdoc (Research)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2019/09/15 - Current	Invited Adjunct Teacher (Polytechnic Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

2019/09 - Current	Invited Assistant Professor (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/15 - 2019/09/14	Invited Adjunct Teacher (Polytechnic Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

2014/09/15 - 2018/09/14	Invited Assistant (Polytechnic Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

2014/02/24 - 2014/06/29	Invited Assistant (Polytechnic Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Projects

Grant

	Designation	Funders
2016/07/01 - 2019/12/15	Impact of a novel vaccine candidate against Group B Streptococcus induced neonatal diseases on commensal microbiota POCI-01-0145-FEDER-016607 (PTDC/IMI-MIC/1049/2014) Post-doc Fellow Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2014/10/01 - 2015/06/30	Integration of cutting-edge health science research and ground-breaking technologies for the development of new clinically useful therapies, tissue regeneration strategies, advanced prophylactic measures and diagnosis methods NORTE-07-0124-FEDER-000021 Post-doc Fellow Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Concluded
2014/01/01 - 2014/09/30	Host-Pathogen Interactions NORTE-07-0124-FEDER 000002 Post-doc Fellow Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Concluded
2008/01/01 - 2013/09/02	Study of the mechanisms involved in neonatal sepsis and meningitis induced by Group B Streptococcus SFRH/BD/38380/2007 PhD Student Fellow Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2022/01 - Current	Advanced therapeutic approaches in addiction: targeting neuroinflammation PTDC/SAU-TOX/0067/2021 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2020 - Current	Meningeal Immunity and neuroInflammatIon: A novel strategy to decipher the cellular and molecular determinants in neonatal bacterial meningitis CEECIND/03675/2018 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia
2023/01 - 2024/06	A novel role for SRCR proteins at the interface of maternal-fetal infections associated with neonatal sepsis (Co-PI) 2022.04792.PTDC Co-Principal Investigator (Co-PI) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia
2023/01 - 2024/06	Epigenetic characterization of Monocyte-Derived Microglia-Like Cells in Human Refractory Epilepsy 2022.10372.PTDC Researcher Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/12/31	Meningeal Immunity and NeuroInflammation: deciphering the immune cells intervening in neonatal bacterial meningitis (PI) EXPL/SAU-INF/1217/2021 Principal investigator Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2009 - 2014	Pre-clinical assays of a GAPDH-based vaccine against Group B Streptococcus infection COMPETE- FEDER PTDC/SAU-MIC/111387/2009 Other	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	Study of the importance of Streptococcus agalactiae extracellular proteins in bovine and mouse mastitis-induced by the bacterium POCTI/CVT/57144/2004 Researcher	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2009 - 2012	IMMUNONET SOE1/P1/E014 Other	Concluded

Outputs

Publications

Conference abstract	Lorga, Inês; Magalhães, Ana; Ana Teixeira; Vilanova, Manuel; Ribot, Julie; Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Altered meningeal gd T cells contribute to neurodevelopment impairment in neonatal bacterial meningitis". Paper presented in 18th International Congress of Immunology (IUIS 2023), Cidade do Cabo, 2024. Published • 10.3389/978-2-8325-1242-5
Conference paper	Dinis, M.; Bonifácio Andrade, Elva; Tavares, D.; Veiga-Malta, I.; Ribeiro, A.; Ferreira, P.. "Streptococcus sobrinus enolase plays an important role in oral colonization by this bacterium". Paper presented in Current Contents of ISI, Philadelphia, 2007. Published
Conference poster	Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Altered meningeal ¿d T cells contribute to neurodevelopment impairment in neonatal bacterial meningitis". Paper presented in 18th International Congress of Immunology, 2023. Rodrigues, João; Bravo, Joana; Bonifácio Andrade, Elva; Lorga, Inês; Vieira, Rita; Azevedo, Maria; Magalhães, Ana; Bettencourt Relvas, João; Summavielle, Teresa. "Psychostimulantabuse and neuroinflammation: findingcritical players in the crosstalk betweenglial cells and neurons.". Paper presented in XVI EuropeanMeeting on Glial Cells in Health andDisease., 2023. Rodrigues, João; Bravo, Joana; Bonifácio Andrade, Elva; Canedo, Teresa; Azevedo, Maria; Summavielle, Teresa. "Regulation of CD47 expression byinterferon-gamma under chronicMethamphetamine exposure". Paper presented in IJUP 2023, 2023. Rodrigues, João; Bravo, Joana; Bonifácio Andrade, Elva; Azevedo, Maria; Summavielle, Teresa; Canedo, Teresa. "Microglia-Neuron crosstalk in chronicMethamphetamine exposure: regulation ofCD47 expression by interferon-gamma". Paper presented in FENS Regional Meeting 2023, 2023. Rodrigues, João; Bravo, Joana; Bonifácio Andrade, Elva; Canedo, Teresa; Azevedo, Maria; Summavielle, Teresa. "Microglia-Neuron crosstalk in chronicmethamphetamine exposure". Paper presented in VIISymposium of the Portuguese GliaNetwork, 2023. Soares, Joana; Lorga, Inês; Bravo, Joana; Summavielle, Teresa; Manuel Vilanova; Bonifácio Andrade, Elva. "Uncovering the microglia response during neonatal Group B Streptococcus meningitis". Paper presented in IJUP’23-16th Youth Research Meeting of the University of Porto, 2023. Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Microglia response to neonatal bacterial meningitis". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023. Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Long-term behavioural sequelae associate with an altered meningeal immune compartment after bacterial neonatal meningitis". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023. Fialho, Sara; Monteiro, Andreia; Lempers, Rose; Bonifácio Andrade, Elva; Ribeiro, Adília; Ferreira, Paula; Oliveira, Laura. "A shift from P2X7 receptors to A2A receptors activation aggravates bacterial dissemination on a mouse model of Perinatal Group B Streptococcal invasive disease". Paper presented in IJUP 2022, Porto, Portugal, 2022. Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Study of the lung immune response to Group B Streptococcus neonatal infection". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022. Fialho, Sara; Bonifácio Andrade, Elva; Ribeiro, Adilia; Ferreira, Paula; Oliveira, Laura. "Unveiling the P2X7 receptor pharmacological signaling role in Perinatal Group B Streptococcal disease". Paper presented in LISA Summer Academy 2021, Hannover, Germany, 2021. Fialho, Sara; Bonifácio Andrade, Elva; Ribeiro, Adilia; Ferreira, Paula; Oliveira, Laura. "Could P2X7 receptors pharmacological targeting be the Aldous Huxley SOMA for Neonatal GBS infection?". Paper presented in AIMS Meeting 2021, Lisboa, Portugal, 2021. Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Maternal GAPDH vaccination against Group B Streptococcus affects postnatal hematopoiesis". Paper presented in XLV Annual Meeting of the Portuguese Society for Immunology, 2019. Bonifácio Andrade, Elva. "Models matter: GAPDH vaccine causes mortality in a mouse model that reflects the human disease". Paper presented in XLIII Annual Meeting of the Portuguese Society for Immunology, 2017. Bonifácio Andrade, Elva. "Neonatal TLR2 signaling leads to IL-10 production that prevents the recruitment of neutrophil to infected or inflamed tissues". Paper presented in XXXVIII Annual Meeting of the Portuguese Society for Immunology, 2012. Bonifácio Andrade, Elva. "IL-10 production through TLR2 signalling is associated with the failure of neonate mice to control the Group B Streptococcus infection". Paper presented in 14th International Congress of Immunology, 2010. Bonifácio Andrade, Elva. "TLR2-signaling is associated with neonatal susceptibility to GBS infection". Paper presented in 2nd European Congress of Immunology, 2009. Bonifácio Andrade, Elva. "The absence of TLR2 is associated with neonatal resistance to GBS infection". Paper presented in . XXXV Annual Meeting of the Portuguese Society for Immunology, 2009. Bonifácio Andrade, Elva. "Signaling through TLR2 increases susceptibility to meningitis by Streptococcus agalactiae". Paper presented in XXXIV Annual Meeting of the Portuguese Society for Immunology, 2008. Bonifácio Andrade, Elva. "TLR2-signaling increases brain colonization in neonatal mice infected with Streptococcus agalactiae". Paper presented in International Congress on Cytokines in Immune Regulation and Disease, 2008.
Journal article	Lorga, Inês; Geraldo, Rafaela; Soares, Joana; Oliveira, Liliana; Firon, Arnaud; Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Development of bioluminescent Group B streptococcal strains for longitudinal infection studies". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-74346-z. 10.1038/s41598-024-74346-z Bonifácio Andrade, Elva. "The impact of psychostimulants on central and peripheral neuro-immune regulation: A scoping review of cytokine profiles and their implications for addiction". Frontiers in Cellular Neuroscience 17 (2023): https://doi.org/10.3389/fncel.2023.1109611. Published Bonifácio Andrade, Elva; Lorga, Inês; Roque, Susana; Geraldo, Rafaela; Mesquita, Pedro; Castro, Rogério; Simões-Costa, Luísa; et al. Corresponding author: Bonifácio Andrade, Elva. "Maternal vaccination against Group B Streptococcus glyceraldehyde-3-phosphate dehydrogenase leads to gut dysbiosis in the offspring.". Brain, behavior, and immunity (2022): https://doi.org/10.1016/j.bbi.2022.04.004. 10.1016/j.bbi.2022.04.004 Teresa Tavares; Liliana Pinho; Bonifácio Andrade, Elva. Corresponding author: Bonifácio Andrade, Elva. "Group B Streptococcal Neonatal Meningitis". Clinical Microbiology Reviews (2022): https://doi.org/10.1128/cmr.00079-21. 10.1128/cmr.00079-21 Joana Bravo; Inês Ribeiro; Ana Filipa Terceiro; Elva B. Andrade; Camila Cabral Portugal; Igor M. Lopes; Maria M. Azevedo; et al. "Neuron–Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity". Cells 11 3 (2022): 355-355. https://doi.org/10.3390/cells11030355. 10.3390/cells11030355 Andrade, Elva Bonifácio; Magalhães, Ana; Puga, Ana; Costa, Madalena; Bravo, Joana; Portugal, Camila Cabral; Ribeiro, Adília; et al. "A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-05492-y. 10.1038/s41467-018-05492-y Alves, Joana; Madureira, Pedro; Baltazar, Maria Teresa; Barros, Leandro; Oliveira, Liliana; Dinis-Oliveira, Ricardo Jorge; Andrade, Elva Bonifácio; et al. "A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice". PLOS ONE 10 12 (2015): e0144196. http://dx.doi.org/10.1371/journal.pone.0144196. 10.1371/journal.pone.0144196 Coelho, Ana Luísa; Araújo, António Manuel; Gomes, Mónica Patrícia; Catarino, Raquel Jorge; Andrade, Elva Bonifácio; Lopes, Agostinho Marques; Medeiros, Rui Manuel. "Combined Ang-2 and VEGF serum levels: holding hands as a new integral biomarker in non-small-cell lung cancers". Future Oncology 11 24 (2015): 3233-3242. http://dx.doi.org/10.2217/fon.15.207. 10.2217/fon.15.207 Andrade, E. B.; Alves, J.; Madureira, P.; Oliveira, L.; Ribeiro, A.; Cordeiro-da-Silva, A.; Correia-Neves, M.; Trieu-Cuot, P.; Ferreira, P.. "TLR2-Induced IL-10 Production Impairs Neutrophil Recruitment to Infected Tissues during Neonatal Bacterial Sepsis". The Journal of Immunology 191 9 (2013): 4759-4768. http://dx.doi.org/10.4049/jimmunol.1301752. 10.4049/jimmunol.1301752 Magalhães, Vanessa; Andrade, Elva Bonifácio; Alves, Joana; Ribeiro, Adilia; Kim, Kwang Sik; Lima, Margarida; Trieu-Cuot, Patrick; Ferreira, Paula. "Group B Streptococcus Hijacks the Host Plasminogen System to Promote Brain Endothelial Cell Invasion". PLoS ONE 8 5 (2013): e63244. http://dx.doi.org/10.1371/journal.pone.0063244. 10.1371/journal.pone.0063244 Oliveira, Liliana; Madureira, Pedro; Andrade, Elva Bonifácio; Bouaboud, Abdelouhab; Morello, Eric; Ferreira, Paula; Poyart, Claire; Trieu-Cuot, Patrick; Dramsi, Shaynoor. "Group B Streptococcus GAPDH Is Released upon Cell Lysis, Associates with Bacterial Surface, and Induces Apoptosis in Murine Macrophages". PLoS ONE 7 1 (2012): e29963. http://dx.doi.org/10.1371/journal.pone.0029963. 10.1371/journal.pone.0029963 Madureira, Pedro; Andrade, Elva Bonifácio; Gama, Bernardo; Oliveira, Liliana; Moreira, Susana; Ribeiro, Adília; Correia-Neves, Margarida; et al. "Inhibition of IL-10 Production by Maternal Antibodies against Group B Streptococcus GAPDH Confers Immunity to Offspring by Favoring Neutrophil Recruitment". PLoS Pathogens 7 11 (2011): e1002363. http://dx.doi.org/10.1371/journal.ppat.1002363. 10.1371/journal.ppat.1002363 Cerca, F.; Andrade, F.; Franca, A.; Andrade, E. B.; Ribeiro, A.; Almeida, A. A.; Cerca, N.; et al. "Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages". Journal of Medical Microbiology 60 12 (2011): 1717-1724. http://dx.doi.org/10.1099/jmm.0.031922-0. 10.1099/jmm.0.031922-0 Trigo, G.; Dinis, M.; Franca, A.; Bonifacio Andrade, E.; Gil da Costa, R. M.; Ferreira, P.; Tavares, D.. "Leukocyte populations and cytokine expression in the mammary gland in a mouse model of Streptococcus agalactiae mastitis". Journal of Medical Microbiology 58 7 (2009): 951-958. http://dx.doi.org/10.1099/jmm.0.007385-0. 10.1099/jmm.0.007385-0 Dinis, Márcia; Tavares, Delfina; Veiga-Malta, Isabel; Fonseca, António J. M. M.; Andrade, Elva Bonifácio; Trigo, Gabriela; Ribeiro, Adília; et al. "Oral Therapeutic Vaccination withStreptococcus sobrinusRecombinant Enolase Confers Protection against Dental Caries in Rats". Journal of Infectious Diseases 199 1 (2009): 116-123. http://dx.doi.org/10.1086/594372. 10.1086/594372 Trigo, Gabriela; Ferreira, Paula; Ribeiro, Niza; Dinis, Márcia; Andrade, Elva Bonifácio; Melo-Cristino, José; Ramirez, Mário; Tavares, Delfina. "Identification of immunoreactive extracellular proteins of Streptococcus agalactiae in bovine mastitis". Canadian Journal of Microbiology 54 11 (2008): 899-905. http://dx.doi.org/10.1139/w08-083. 10.1139/w08-083

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/06	New players in neonatal bacterial meningitis: The role of meningeal gd T cells	10th International gd T cell conference (Lisbon, Portugal)
2023/05	A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection	5ªr RACS - Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia Universidade do Mindelo (Cidade de Mindelo, Cape Verde)
2023/03/28	Sex differences in immunity	BioEng.Hub - Advances on our understanding of the health issues for women Instituto de Investigação e Inovação em Saúde (Portugal)
2023/03	Friend or foe: The role of gd17 T cells in neonatal bacterial meningitis	I ImmunoHUB Annual Meeting (Porto, Portugal)
2023/02	Disclosing the role of meningeal immunity during Group B Streptococcus neonatal infection	9th Molecular and Cell Biology Symposium (Porto, Portugal)
2021/07	A mouse model reproducing the pathophysiology of neonatal group B streptococcal disease	International Conference on Group B Strep (ICGBS) Group B Strep International
2021/03	Neonatal Group B Streptococcus meningitis affects the immune cell composition in the meninges and periphery	AIMS Meeting (Lisbon, Portugal)
2019/11	The critical impact of animal models to study Group B Streptococcal neonatal infection	Day of the Microbiology Laboratory (Porto, Portugal)
2019/10	Opposite effects of maternal GAPDH vaccination: the critical impact of animal models to study Group B Streptococcus neonatal infection	17th International Congress of Immunology. Beijing, China (Beijing, China)
2019/09	A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection	2nd Edition of Euro-Global Conference on Pediatrics and Neonatology (Londres, United Kingdom)
2016/04	A Novel Mouse Model of Neonatal Sepsis and Meningitis for Vaccine Studies	VI Technical Symposium on Pathological Anatomy (Porto, Portugal)
2015/03	Development of the first mouse model that mimics the GBS-induced neonatal human disease	III AEICBAS Biomedical Congress (Porto, Portugal)
2014/10	IL-10 production through TLR2 is a key event in neonatal susceptibility to GBS induced sepsis	XL Annual Meeting of the Portuguese Society for Immunology (Lisbon, Portugal)
2013/11	Ablation of IL-10 signaling through TLR2 led to enhanced Group B streptococcus control	XXXIX Annual Meeting of the Portuguese Society for Immunology (Coimbra, Portugal)
2011/11	TLR2 as a prospective target for the immunotherapy of Group B Streptococcus	6th Meeting of the immunotherapy network IMMUNONET (Montpellier, France)
2011/05	TLR2 as a prospective target for the immunotherapy of Streptococcus agalactiae	International Conference: New Trends in Immunotherapy (Madrid, Spain)
2011/05	The ST17 hypervirulent clone of Group B Streptococcus induces the disruption of human brain microvascular endothelial cells	1st European Conference of Microbiology and Immunology (Budapeste, Hungary)
2010/09	Ablation of IL-10 signaling through TLR2 led to enhanced Group B streptococcus control	XXXVI Annual Meeting of the Portuguese Society for Immunology (Braga, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/11 - Current	Gut-Meningeal Axis in Neonatal Bacterial Infection: Unveiling Pathophysiological Mechanisms for Targeted Therapies Supervisor of Nuno Ribeiro	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - Current	Influence of Group B Streptococcus exposure on the development of psychiatric disorders in adolescence Supervisor of Ana Teresa Vieira da Costa Tavares	Ciências Médicas (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023 - Current	Estudo da migração da microglia na meningite neonatal Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021 - Current	Identification of biomarkers of clinical phenotype and disease activity in systemic lupus erythematosus Co-supervisor of Daniel Guimarães de Oliveira	PhD Programme Medical Sciences (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/11/01 - Current	Meningeal immunity: Deciphering the cellular and molecular determinants in neonatal meningitis Supervisor of Inês Sampaio e Lorga	Biologia Molecular e Celular (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09 - 2023/10	Determining the impact of perinatal inflammation induced by Group B Streptococcus on long-term brain deficits Supervisor	Bioquímica (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2023	Caracterização morfológica da patologia pulmonar após infeção neonatal por estreptococos do grupo B Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022 - 2023	Papel dos Linfócitos T gd nas meninges após Infeção neonatal por Streptococcus do grupo B Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/09 - 2022/12	Study of the lung immune response to group B streptococcal neonatal infection Supervisor	Master Degree in Cellular and Molecular Biology (Master) Universidade do Porto Faculdade de Ciências, Portugal
2020/09 - 2021/07	The Role of IL-10 in the Development of Mesial Temporal Lobe Epilepsy Co-supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09 - 2021/02/24	Development and characterization of a bioluminescent Group B Streptococcus reporter bacteria to study neonatal meningitis caused by this pathogen Supervisor	Microbiologia Aplicada (Master) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2019/09 - 2020/12/17	Characterization of the meningeal immune cells in neonatal Group B Streptococcus meningitis Supervisor	Bioquímica (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09 - 2020/11	Unravelling the role of Interferon-g in the immunopathology induced by maternal GAPDH vaccination Co-supervisor	Biologia Celular e Molecular (Master) Universidade do Porto Faculdade de Ciências, Portugal
2018/09 - 2019/12	Maternal GAPDH vaccination: evaluation of hematopoietic changes in their offspring Supervisor	Biologia Celular e Molecular (Master) Universidade do Porto Faculdade de Ciências, Portugal
2018/01 - 2019/07	Uncovering the mechanisms associated with maternal GAPDH vaccination-induced mortality in a mouse model that reflects the human GBS disease Supervisor	Biologia (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2017/09 - 2018/09	Uncovering the effects of maternal rGAPDH vaccination on intestinal immune system of the offspring Supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09 - 2018/07	GAPDH maternal vaccination causes mortality in a mouse model that reflects the human Group B Streptococcus disease Supervisor	Biologia (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2017/09 - 2018/07	GAPDH maternal vaccination affects brain's myeloid cells of their offspring Supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09 - 2018/07	Estudo da resposta neuroinflamatória num modelo experimental de meningite neonatal Supervisor	Anatomia Patológica Tanatológica e Citológica (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2016/09 - 2017/07	Exploring the impact of GAPDH maternal vaccination in the immune system composition of their offspring Supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/09 - 2016/11	Impact of a novel vaccine candidate against Group B Streptococcus induced neonatal diseases on commensal microbiota Supervisor	Bioquímica (Master) Universidade do Porto Faculdade de Ciências, Portugal
2015/09 - 2016/07	The synergic effect of Glyceraldehyde 3-phosphate dehydrogenase on Group B Streptococcus infection Co-supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/09 - 2015/09	Evaluation of the molecular mechanisms involved in the pathogeny of GBS-induced meningitis after vertical transmission of bacteria Supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/09 - 2013/09	Characterization of an experimental model of neonatal meningitis induced by Group B Streptococcus Co-supervisor	Bioquímica (Master) Universidade do Porto Faculdade de Ciências, Portugal
2010/09 - 2011/07	Study of Group B Streptococcus interaction with Human Brain Microvascular Endothelial Cells Co-supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009/09 - 2010/07	Development of a natural neonatal mouse model GBS-induced meningitis in BALB/c mice Co-supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008/09 - 2009/07	Development of a neonatal mouse model of GBS infection and study of TLR2 signaling in the susceptibility to this infection Co-supervisor	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/05/08 - Current	THIRD MEETING PHD IN BIOMEDICAL SCIENCES \| Member of the organizing and scientific committee. (2023/05/08) Congress (Co-organisor)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/12/03 - 2021/12/04	Introduction To Spectral Flow Cytometry: Concepts and Applications (2021/12/03 - 2021/12/04) Workshop (Member of the Organising Committee)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019/12/20 - 2019/12/20	SECOND MEETING PHD IN BIOMEDICAL SCIENCES \| Member of the organizing committee. Moderator of the session “Biochemistry and Molecular and Cellular Biology”. (2019/12/20 - 2019/12/20) Congress (Co-organisor)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/05/07 - 2018/05/07	FIRST MEETING PHD IN BIOMEDICAL SCIENCES \| Member of the organizing and scientific committee. Moderator of the session “Neurosciences and Behaviour”. (2018/05/07 - 2018/05/07) Congress (Co-organisor)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/11/19 - 2015/11/21	II INTERNATIONAL HEALTH CONGRESS GAIA-PORTO “FROM DIAGNOSIS TO INTERVENTION \| Member of the organizing and scientific committee of the session entitled “Immunomodulation and Immune-mediated Therapeutic Strategies for Chronic Diseases”. Moderator of the session. (2015/11/19 - 2015/11/21) Congress (Member of the Organising Committee)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2015 - Current	Outreach activity through open days in the laboratory, to promote scientific introduction and communication to high school students. Workshop	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01 - 2020/01	Building and Leading Research Teams Workshop	Building and Leading Research Teams Universidade do Porto Faculdade de Psicologia e de Ciências da Educação, Portugal
2019/10/07 - 2019/10/10	Participation in a course Flow Cytometry course to improve skills. The course aimed to provide scientists with basic and advanced knowledge to begin or improve their skills on flow-cytometry experiments, together with an overview of the most advanced techniques and biological questions that can be addressed using flow cytometry. Workshop	Flow Cytometry Workshop - From basic knowledge to advanced applications Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/09	The Development of a Novel Infection Model to Test CSF1-Fc as a Potential Therapeutic for Early Onset Sepsis (Thesis) Main arguer	Nicola Ann Li (Master) The University of Edinburgh Medical School, United Kingdom
2023/09	Epigenetic regulation of epilepsy-related signalling pathways and its impact on epileptogenesis (Thesis) Arguer	Ricardo Alexandre Martins Ferreira (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/14	SSC5D expression and secretion during pregnancy-associated infections (Thesis) Main arguer	Isadora Maia Sousa (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/06/01	SRCR proteins as pattern recognition receptors: expanding the search for interactions with pathogens (Thesis) Main arguer	Marcos S. Cardoso (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021	Using IL-10 to Attenuate Meth Induced Inflammation (Thesis) Main arguer	Ana Isabel Reis da Silva Almeida Guimarães (Other) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020	Dissecting the molecular mechanisms of CD5L action in the early events of sepsis (Thesis) Main arguer	Ana Patrícia Oliveira Gomes (Master) Universidade do Porto Faculdade de Ciências, Portugal
2020	Dissecting t cell signaling: a dual function of CD6 that impacts on T cell responses and autoimmunity (Thesis) Arguer	Ana Rita Faria dos Santos (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019	Flow Cytometry Intracellular IFNg Detection in Peripheral Blood of Cancer Patients (Thesis) Main arguer	Andreia Rafaela Linhares Miranda (Other) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019	Influence of HOXA9 in the response of glioblastoma to immune checkpoint inhibitors (Thesis) Main arguer	Ana Catarina Mesquita Azevedo (Master) Universidade do Minho, Portugal
2018	Evaluation of Serological Based Diagnosis for Human Visceral Leishmaniasis (Thesis) Main arguer	Kevin Israel Muñoz (Master) Universidade de Coimbra, Portugal
2017	Innate Immunity: Molecular and functional aspects of Blood Cell Heterogeneity in Drosophila (Thesis) Main arguer	Rafael Baganha Carreiras (Other) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015	Uncovering the binding and functional properties of S4D-SRCRB and Spa (Thesis) Main arguer	Sarah Raquel Matos Almeida (Master) Universidade de Aveiro, Portugal
2012/07/20	Role of adipose tissue in the immune response to Neospora caninum infection (Thesis) Main arguer	Soraia dos Santos Lopes (Other) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2024 - Current	Brain, Behavior, and Immunity
2023/06 - Current	Acta Médica Portuguesa
2022/05 - Current	Psychoneuroendocrinology
2022 - Current	Pathogens
2019 - Current	Scientific Reports (2045-2322)

Association member

	Society Organization name	Role
2021/11/20 - Current	Member of the American Society for Microbiology
2021/10/25 - Current	International Society of Neuroimmunology
2019 - Current	European Society of Clinical Microbiology and Infectious Diseases
2005 - Current	Sociedade Portuguesa de Imunologia

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020 - Current	Immunology	Medicina Dentária (Mestrado integrado)	Universidade do Porto Faculdade de Medicina Dentária, Portugal
2020 - Current	Immune Response and Disease	Técnicas Laboratoriais em Biopatologia (Mestrado integrado)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019 - Current	Microbiology	Medicina Veterinária (Mestrado integrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/09 - Current	Immunology	Ciências Biomédicas Laboratoriais (Licenciatura)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2014/02 - Current	Immunology	Bioquímica em Saúde (Mestrado integrado)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2014/09 - 2016/09	Immunology	Anatomia Patológica Citológica e Tanatológica (Licenciatura)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2015/09 - 2016/01	Microbiology and Infection	Anatomia Patológica Citológica e Tanatológica (Licenciatura)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2018/10/31	Media coverage for Andrade et al, Nat Commun, 2018	Público

Other jury / evaluation

	Activity description	Institution / Organization
2022 - Current	Project evaluation for the French National Research Agency (ANR)
2018/06/30 - 2018/06/30	Examiner - PhD Seminar, PhD in Pharmaceutical Sciences, University of Porto "Redefining the role antibodies play in protection against Plasmodium’s pre-erythrocytic phase". PhD Student:Ana Rafaela Azevedo Teixeira	Universidade do Porto Faculdade de Farmácia, Portugal

Distinctions

Award

2023	“Best Scientific Paper in Pediatry” for the paper “Group B Streptoccocal Neonatal Meningitis”. Centro Hospitalar Universitário do Porto, Centro Materno Infantil do Norte, Porto, Portugal.
2021	National nominee for the ACTERIA Early Career Research Prizes in Immunology and Allergology.
2019	“SPI Paper Award 2019” for the paper “A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection”.
2013	Excellence in Immunology “Mario Arala Chaves Award”

Other distinction

2019	Stimulus of Scientific Employment, Individual Support – 2018 Call Fundação para a Ciência e a Tecnologia, Portugal
2012	Honorable mention for the poster entitled “Neonatal TLR2 signaling leads to IL-10 production that prevents the recruitment of neutrophil to infected or inflamed tissues”