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Eduardo Alexandre Pereira da Silva, BSc in Biochemistry and MSc in Applied Biochemistry by the University of Minho. Eduardo Silva completed his BSc ( Final grade of 16) in 2015 and immediately continued his academic journey by enrolling in the Applied Biochemistry - specialization of Biotechnology MSc, coordinated by both the Biology and Chemistry department of the University of Minho. The completion of the MSc came about in December 2018 with the defense of the Master thesis entitled " Effects of radiation on the molecular dynamics of Pseudomonas aeruginosa", being award a final grade of 17 out 20. During the thesis years, he acquired several skills in the fields of microbiology, molecular biology, proteomics, functional genomics and metagenomics. Posteriorly, he held the position of Investigator, via a grant under the scope of the DES-ZYME project, at the Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho (I3Bs). The work developed was focused on the exploration of natural deep eutectic solvents as agents to potentiate therapeutic activity/effects of active pharmaceutical ingredients, among which antibacterial activity which resulted in several publications. During this time he also participated the writing of a review focusing on light-based therapeutics more specifically, in the use of light as a trigger for on-cue drug release systems and spatiotemporal restriction of drug activity, which resulted in the co-authorship of the article entitled "Light-triggered release of photocaged therapeutics-Where are we now?" published in the Journal of Controlled Release ( 5-year impact factor : 8.863). Currently, he holds the position of PhD student at I3BS, under the scope of the TERM&SC PhD program. His work revolves around the use of light-based therapeutics for the treatment of bacterial infections with emphasis on the development of platforms with on-demand light-triggered antibacterial activity and novel approaches for traditional light-based therapies (e.g. antimicrobial Photodynamic Therapy)
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Identification

Personal identification

Full name
EDUARDO ALEXANDRE PEREIRA DA SILVA

Citation names

  • Silva, Eduardo

Author identifiers

Ciência ID
521D-E545-32BC
ORCID iD
0000-0003-4833-9946

Email addresses

  • eduardo.silva@I3Bs.uminho.pt (Professional)

Telephones

Mobile phone
  • 968556813 (Personal)

Addresses

  • I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho,AvePark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães , Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Exact Sciences - Chemical Sciences - Electrochemistry
  • Engineering and Technology - Chemical Engineering - Chemical Engineering
  • Engineering and Technology - Industrial Biotechnology - Biocatalysis
  • Engineering and Technology - Chemical Engineering - Chemical Engineering
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/09/01 - 2023/09/01
Ongoing
 PhD program on Tissue engineering, regenerative medicine and stem cells (Doutoramento)
Laboratório Associado ICVS 3B's, Portugal
"Photoswitchable approaches towards on-demand dynamic triggering of antimicrobial activity" (THESIS/DISSERTATION)
2018/02/01 - 2018/02/19
Concluded
 Biology Meets Programming: Bioinformatics for Begginers (Outros)
Major in Bioinformatic
University of San Diego, United States
 95.1%
2015/09/01 - 2017/12/12
Concluded
 Bioquímica Aplicada (Mestrado)
Major in Biotecnologia
Universidade do Minho, Portugal
""Effects of radiation on the molecular dynamics of Pseudomonas aeruginosa”" (THESIS/DISSERTATION)
 17
2012/09/15 - 2015/07/16
Concluded
 Bioquímica (Licenciatura)
Universidade do Minho, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2019/09/01 - 2023/09/01 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Laboratório Associado ICVS 3B's, Portugal
2018/08/08 - 2019/04/04 Researcher (Research) Universidade do Minho, Portugal
Laboratório Associado ICVS 3B's, Portugal
Projects

Grant

Designation Funders
2019/09/01 - 2023/10/01 Photoswitchable approaches towards on-demand dynamic triggering of antimicrobial activity
SFRH/BD/143902/2019
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2019/10/14 - 2023/10/14 Green Chemical Engineering Network towards upscaling sustainable processes
CA18224
Researcher
Universidade Nova de Lisboa, Portugal
 European Cooperation in Science and Technology
Ongoing
2018/07/01 - 2021/06/30 Valorização de resíduos de eucalipto usando biocatalisadores baseados em Pseudomonas
PTDC/EAM-AMB/30488/2017
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/08 - 2019/04/04 DES-ZYME: Biocatalytic separation of enantiomers using Natural Deep Eutectic Solvent
PTDC/BBB-EBB/1676/2014
Research Fellow
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Beatriz Domingues; Silva, Eduardo; Lima, Estêvão; Alexandre A. Barros; Rui L. Reis. "Electrically responsive drug delivery hydrogel for ureteral stent application". Paper presented in HEALTH-UNORTE Conference, 2023.
  2. Domingues, B; Silva, Eduardo; Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "Biodegradable and electroactive hydrogel as a drug delivery system to manage ureteral stent-associated pain". Paper presented in Final Achilles Conference, 2022.
  3. Filipe Oliveira; Silva, Eduardo; Joana M. Silva; Carolina Pereira; Ana Matias; Reis, Rui L.; Ana Rita C. Duarte. "Menthol-fatty acids deep eutectic systems as wound healing agents". Paper presented in 1st Greenering International Conference, 2021.
  4. Silva, Eduardo; Angélica Hernández-Arriaga; Amélia Camarinha da Silva; Barros, Alexandre; Silva, Joana M.; Reis, Rui L.. "Unveiling the bacterial colonizers of ureteral stents". Paper presented in TERMSTEM 2019, 2019.
  5. Silva, Joana M.; Silva, Eduardo; Reis, Rui L.; Ana Rita C. Duarte. "Unravelling the role of deep eutectic solvents in therapeutic applications". Paper presented in TERMSTEM 2019, 2019.
  6. Silva, Eduardo; Ivo M. Aroso; Barros, Alexandre; Silva, Joana M.; Reis, Rui L.. "Functionalization of ureteral stents with fatty acids via supercritical technology". Paper presented in FORECAST 2019, 2019.
  7. Silva, Joana M.; Silva, Eduardo; Ana Rita C. Duarte; Reis, Rui L.. "Multifunctionality of deep eutectic solvents based on menthol and fatty acids". Paper presented in Forecast 2nd Workshop, 2019.
  8. Pacheco, Margarida; Silva, Joana M.; Aroso, Ivo; Silva, Eduardo; Barros, Alexandre; Reis, Rui L.. "Curcumin impregnation by supercritical fluid technology in silicon-based ureteral stents". Paper presented in Forecast 2nd Workshop, 2019.
  9. Silva, Joana M.; Silva, Eduardo; Ana Rita C. Duarte; Reis, Rui L.. "Unravel the antimicrobial potential of eutectic blends based on fatty acids". Paper presented in 1st International Meeting on Deep Eutectic Systems, 2019.
  10. Silva, Joana M.; Silva, Eduardo; Reis, Rui L.; Ana Rita C. Duarte. "A closer look on the multifunctionality of deep eutectic solvents based on menthol and fatty acids". Paper presented in 1st International Meeting on Deep Eutectic Systems, 2019.
Journal article
  1. Oliveira, Filipe; Silva, Eduardo; Matias, Ana; Silva, Joana M.; Reis, Rui L.; Duarte, Ana Rita C.. "Menthol-based deep eutectic systems as antimicrobial and anti-inflammatory agents for wound healing". European Journal of Pharmaceutical Sciences 182 (2023): 106368. http://dx.doi.org/10.1016/j.ejps.2022.106368.
    10.1016/j.ejps.2022.106368
  2. Kardelen Ecevit; Eduardo Silva; Luísa C. Rodrigues; Ivo Aroso; Alexandre A. Barros; Joana M. Silva; Rui L. Reis. "Surface Functionalization of Ureteral Stents-Based Polyurethane: Engineering Antibacterial Coatings". Materials (2022): https://doi.org/10.3390/ma15051676.
    10.3390/ma15051676
  3. Silva, Joana M.; Silva, Eduardo; Reis, Rui L.. "Therapeutic deep eutectic solvents assisted the encapsulation of curcumin in alginate-chitosan hydrogel beads". Sustainable Chemistry and Pharmacy 24 (2021): 100553. http://dx.doi.org/10.1016/j.scp.2021.100553.
    10.1016/j.scp.2021.100553
  4. Eduardo Silva; Filipe Oliveira; Joana M. Silva; Rui L. Reis; Ana Rita C. Duarte. "Untangling the bioactive properties of therapeutic deep eutectic solvents based on natural terpenes". Current Research in Chemical Biology 1 (2021): 100003-100003. https://doi.org/10.1016/j.crchbi.2021.100003.
    10.1016/j.crchbi.2021.100003
  5. Silva, Eduardo; Oliveira, Filipe; Silva, Joana M.; Matias, Ana; Reis, Rui L.; Duarte, Ana Rita C.. "Optimal Design of THEDES Based on Perillyl Alcohol and Ibuprofen". Pharmaceutics 12 11 (2020): 1121. http://dx.doi.org/10.3390/pharmaceutics12111121.
    Open access • 10.3390/pharmaceutics12111121
  6. Silva, Joana M.; Silva, Eduardo; Reis, Rui L.; Duarte, Ana Rita C.. "A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids". Sustainable Chemistry and Pharmacy 14 (2019): 100192. http://dx.doi.org/10.1016/j.scp.2019.100192.
    Published • 10.1016/j.scp.2019.100192
  7. Silva, Joana M.; Pereira, Carolina V.; Mano, Francisca; Silva, Eduardo; Castro, Vânia I. B.; Sá-Nogueira, Isabel; Reis, Rui L.; et al. "Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healing". ACS Applied Bio Materials 2 10 (2019): 4346-4355. http://dx.doi.org/10.1021/acsabm.9b00598.
    10.1021/acsabm.9b00598
  8. Silva, Joana M.; Silva, Eduardo (521D-E545-32BC); Reis, Rui L.. "Light-triggered release of photocaged therapeutics - Where are we now?". Journal of Controlled Release 298 (2019): 154-176. http://dx.doi.org/10.1016/j.jconrel.2019.02.006.
    Published • 10.1016/j.jconrel.2019.02.006
Thesis / Dissertation
  1. Silva, Eduardo. "Effects of radiation on the molecular dynamics of Pseudomonas aeruginosa". Master, Universidade do Minho Centro de Biologia Molecular e Ambiental, 2017.

Other

Other output
  1. Journal cover of ACS Applied Bio Materials. Deep eutecticsolvents are recently attracting wide interest in biomedical andpharmaceutical fields due to their easy production and ability to include activepharmaceutical ingredients as a counterpart of a mixture of two or morecompounds.This cover depicts the recent advances made in the design ofnovel deep eutectic solvents based on menthol and saturated fatty acidstowards the wound healing.. 2019. Silva, Joana M.; Carolina V. Pereira; Francisca Mano; Silva, Eduardo; Castro, Vânia I. B.; Isabel Sá-Nogueira; Reis, Rui L.; et al. https://pubs.acs.org/toc/aabmcb/2/10.
  2. Clinical Trials : StentGenomic - Identification and evaluation of the microbial population colonizing ureteral catheters. Clinical Trials: Hospital de Braga, EPE, 89 Patients, Urology Department. 2019. Silva, Eduardo; Andreia Cardoso; Paulo Mota; Barros, Alexandre; Silva, Joana M.; Amélia Camarinha da Silva; Reis, Rui L..
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/09/21 Anticancer and antibacterial effect of curcumin-loaded ureteral stents. Training School: Advances in urinarystents: Biomaterials, coatings and drug eluting stents
(Lubin , Poland)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/01/04 - 2021/01/15 Cell culture Lab Training
Other
Biomaterials Biodegradables and Biomimetics, Portugal
2020/01/13 - 2020/01/13 Training on Rheometer
Other
 Training on Rheometer
Laboratório Associado ICVS 3B's, Portugal
2019/11/06 - 2019/11/06 Participation in TERSTEM 2019
Conference
 TERSTEM 2019
Laboratório Associado ICVS 3B's, Portugal
2019/11/04 - 2019/11/05 Participation in Second Achilles Conference
Conference
 Second Achilles Conference
Laboratório Associado ICVS 3B's, Portugal
2019/10/04 - 2019/10/04 Training on UV curing System
Other
 Training on UV Curing System
Laboratório Associado ICVS 3B's, Portugal
2019/09/25 - 2019/09/27 Participation in 1st Discoveries Forum on Regenerative and Precision Medicine
Conference
 1st Discoveries Forum on Regenerative and Precision Medicine
Laboratório Associado ICVS 3B's, Portugal
2019/07/11 - 2019/07/12 Participation in Forecast second workshop
Conference
 Forecast second workshop
Laboratório Associado ICVS 3B's, Portugal
2019/07/08 - 2019/07/11 Participation in First Achilles Conference 2019
Conference
 First Achilles Conference 2019
Laboratório Associado ICVS 3B's, Portugal
2019/04/26 - 2019/04/26 Training on Differential Scanning Calorimetry
Other
 Training on Differential Scanning Calorimetry
Laboratório Associado ICVS 3B's, Portugal
2018/10/24 - 2018/10/26 Participation in the Chem2nature final conference
Conference
 Chem2nature final conference
Laboratório Associado ICVS 3B's, Portugal
2018/10/23 - 2018/10/24 Participation in the Gene2skin final conference
Conference
 Gene2skin final conference
Laboratório Associado ICVS 3B's, Portugal
2018/09/17 - 2018/09/17 Training on Microbiology Lab
Other
 Training on Microbiology Lab
Laboratório Associado ICVS 3B's, Portugal