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Licenciada (2008) e Bacharel (2009) em Ciências Biológicas na UNESP de São José do Rio Preto. Mestre (2011) e doutora (2015) em Biologia Molecular pela Universidade Federal de São Paulo (UNIFESP). Fez pós-doutorado (2015- 2017) na mesma instituição e tem experiência em Enzimologia, Bioquimica e Química de Proteínas, assim como expressão e purificação de proteínas e análises por espectrometria de massas. Atualmente é orientadora permanente do Programa de Pós-Graduação em Nefrologia (Universidade Federal de São Paulo - Escola Paulista de Medicina), coordenadora de curso de pós-graduação em Medicina Translacional, Inspetora Interna de Controle de Qualidade PALC do Laboratório Central do Hospital São Paulo; e pesquisadora associada e supervisora do Laboratório de Rim e Hormônios (UNIFESP-EPM), com colaborações estabelecidas com grupos da mesma instituição de ensino, nacionais e internacionais. Trabalha com enzimas e peptídeos do Sistema Renina Angiotensina e Sistema Calicreína Cinina, hipertensão, obesidade e COVID-19, cultura de células humanas, compostos obesogênicos, exposômica e metabolômica.
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Identification

Personal identification

Full name
Lilian Caroline Gonçalves de Oliveira

Citation names

  • Oliveira, LCG

Author identifiers

Ciência ID
5317-C393-E6C3
ORCID iD
0000-0001-5117-6979

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2011 - 2015
Concluded
 Biologia Molecular (Doutoramento)
Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brazil
"Estudo de catepsinas B-símile derivadas de Trypanosoma congolense com a utilização de bibliotecas combinatórias sintéticas de peptídeos fluorescentes" (THESIS/DISSERTATION)
2009 - 2011
Concluded
 Biologia Molecular (Mestrado)
Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brazil
"Efeitos de agentes moduladores do microambiente nas propriedades hidrolíticas e estruturais da peptidase 3CL do SARS Coronavírus" (THESIS/DISSERTATION)
2008 - 2009
Concluded
 Ciências Biológicas (Bachelor)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de São José do Rio Preto, Brazil
" Propriedades Hidroliticas da Peptidase 3CL do SARS coronavírus" (THESIS/DISSERTATION)
2005 - 2008
Concluded
 Ciências Biológicas (Licence)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de São José do Rio Preto, Brazil
""Práticas de Ensino em Microbiologia e Parasitologia: Aspectos Gerais de Higiene e Saúde"" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2017 - Current Principal Investigator (Research) Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brazil
2015 - 2017 Postdoc (Research) Universidade Federal de São Paulo, Brazil
Projects

Contract

Designation Funders
2021 - Current Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua
2018/23105-6
Researcher
Universidade de São Paulo, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Ongoing
2020 - Current Projeto Temático: Sistemas hormonais nas doenças renais e cardiovasculares: da biologia celular a novos paradigmas fisiológicos com avanços para a terapêutica.
2017/17027-0
Researcher
Universidade Federal de São Paulo, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Ongoing
2020 - Current Estudo de polimorfismo genético e atividade das enzimas conversoras de angiotensina (ECA1 e ECA2) em pacientes de COVID19
1424
Researcher
Universidade Federal de São Paulo, Brazil
 JBS SA
Ongoing
2019 - 2021 Exposômica aplicada ao perfil de metabólitos e compostos obesogênicos na urina de pré-púberes não saudáveis
2018/23953-7
Principal investigator
Universidade Federal de São Paulo, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Outputs

Publications

Journal article
  1. Renata Vitoriano Corradi Gomes; A. Augusto Peluso; Fernanda Aparecida Ronchi; Lilian Caroline Gonçalves de Oliveira; Dulce Elena Casarini; Robson Augusto Souza Santos; Patrick Wander Endlich; Glaucia Rodrigues de Abreu. "Antihypertensive treatment of end-stage renal disease patients on hemodialysis does not alter circulating ACE and ACE2 activity and angiotensin peptides". The American Journal of the Medical Sciences (2023): https://doi.org/10.1016/j.amjms.2023.11.014.
    10.1016/j.amjms.2023.11.014
  2. Mariana Ferreira-Duarte; Lilian Caroline Gonçalves Oliveira; Clara Quintas; Marisa Esteves-Monteiro; Margarida Duarte-Araújo; Teresa Sousa; Dulce Elena Casarini; Manuela Morato. "ACE and ACE2 catalytic activity in the fecal content along the gut". Neurogastroenterology & Motility (2023): https://doi.org/10.1111/nmo.14598.
    10.1111/nmo.14598
  3. Nayara Azinheira Nobrega Cruz; Lilian Caroline Gonçalves de Oliveira; Fernanda Barrinha Fernandes; Divanei dos Anjos Zaniqueli; Polyana Romano Oliosa; José Geraldo Mill; Dulce Elena Casarini. "Pediatric dyslipidemia is associated with increased urinary ACE activity, blood pressure values, and carotidal-femoral pulse wave velocity". Hypertension Research 46 6 (2023): 1558-1569. http://dx.doi.org/10.1038/s41440-023-01240-y.
    10.1038/s41440-023-01240-y
  4. Lilian Caroline Gonçalves de Oliveira; Isabel Cristina Mallostro Emerich de Abreu; Raquel Cristina Melo Ferreira de Albuquerque; Ana Beatriz Pereira Brandão; Leticia Barssotti; Lívia Bruni de Souza; Fabiana Gomes Ferreira; et al. "Saccharomyces boulardii exerts renoprotection by modulating oxidative stress, renin angiotensin system and uropathogenic microbiota in a murine model of diabetes". Life Sciences 301 (2022): 120616-120616. http://dx.doi.org/10.1016/j.lfs.2022.120616.
    10.1016/j.lfs.2022.120616
  5. Mark Damen; Mario Izidoro; Debora Okamoto; Lilian Oliveira; Helene Amatdjais-Groenen; Stijn van Dongen; Koen van Cleef; et al. "Cationic Geminoid Peptide Amphiphiles Inhibit DENV2 Protease, Furin, and Viral Replication". Molecules (2022): https://doi.org/10.3390/molecules27103217.
    10.3390/molecules27103217
  6. Ho Chi Hsien; Dulce Elena Casarini; João Tomas de Abreu Carvalhaes; Fernanda Aparecida Ronchi; Lilian Caroline Gonçalves de Oliveira; Josefina Aparecida Pellegrini Braga. "Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease". Brazilian Journal of Nephrology (2021): https://doi.org/10.1590/2175-8239-jbn-2020-0174.
    10.1590/2175-8239-jbn-2020-0174
  7. "Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 Patients". Frontiers in Physiology 12 (2021): http://dx.doi.org/10.3389/fphys.2021.700220.
    10.3389/fphys.2021.700220
  8. "Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation". Journal of Venomous Animals and Toxins including Tropical Diseases (2021): https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100304&tlng=en.
    10.1590/1678-9199-jvatitd-2020-0098
  9. Lilian Caroline Gonçalves Oliveira; Nayara Azinheira Nobrega Cruz; Bruna Ricelli; Helio Tedesco-Silva Jr; José Osmar Medina-Pestana; Dulce Elena Casarini. "Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy". Journal of Venomous Animals and Toxins including Tropical Diseases (2021): https://doi.org/10.1590/1678-9199-jvatitd-2020-0181.
    10.1590/1678-9199-jvatitd-2020-0181
  10. "Inhibition of the P2X7 receptor improves renal function via renin-angiotensin system and nitric oxide on diabetic nephropathy in rats". Life Sciences (2020): http://dx.doi.org/10.1016/j.lfs.2020.117640.
    10.1016/j.lfs.2020.117640
  11. "Evaluation of the milk clotting properties of an aspartic peptidase secreted by Rhizopus microsporus". Preparative Biochemistry & Biotechnology (2020): http://dx.doi.org/10.1080/10826068.2019.1683861.
    10.1080/10826068.2019.1683861
  12. "Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo.". Scientific reports (2019): http://europepmc.org/articles/PMC6397221.
    10.1038/s41598-019-39842-7
  13. "Biochemical Properties and Catalytic Specificity of a Novel Neutral Serine Peptidase Secreted by Fungus Pyrenochaetopsis sp.". Applied biochemistry and biotechnology (2018): https://doi.org/10.1007/s12010-018-2875-3.
    10.1007/s12010-018-2875-3
  14. "Rapid detection of ceftazidime/avibactam resistance by MALDI-TOF MS.". The Journal of antimicrobial chemotherapy (2018): https://doi.org/10.1093/jac/dky196.
    10.1093/jac/dky196
  15. "Functional roles of C-terminal extension (CTE) of salt-dependent peptidase activity of the Natrialba magadii extracellular protease (NEP).". International journal of biological macromolecules (2018): https://doi.org/10.1016/j.ijbiomac.2018.03.026.
    10.1016/j.ijbiomac.2018.03.026
  16. "Design and characterization of crotamine-functionalized gold nanoparticles.". Colloids and surfaces. B, Biointerfaces (2017): https://doi.org/10.1016/j.colsurfb.2017.12.013.
    10.1016/j.colsurfb.2017.12.013
  17. "Interface between breast cancer cells and the tumor microenvironment using platelet-rich plasma to promote tumor angiogenesis - influence of platelets and fibrin bundles on the behavior of breast tumor cells.". Oncotarget (2017): http://europepmc.org/articles/PMC5370006.
    10.18632/oncotarget.15170
  18. "Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?". Biochimica et biophysica acta. Proteins and proteomics (2017): https://doi.org/10.1016/j.bbapap.2017.02.017.
    10.1016/j.bbapap.2017.02.017
  19. "Biochemical and milk-clotting properties and mapping of catalytic subsites of an extracellular aspartic peptidase from basidiomycete fungus Phanerochaete chrysosporium.". Food chemistry (2017): https://doi.org/10.1016/j.foodchem.2017.01.009.
    10.1016/j.foodchem.2017.01.009
  20. "Activity of a peptidase secreted by Phanerochaete chrysosporium depends on lysine to subsite S'1.". International journal of biological macromolecules (2016): https://doi.org/10.1016/j.ijbiomac.2016.10.063.
    10.1016/j.ijbiomac.2016.10.063
  21. "Evaluation of the catalytic specificity, biochemical properties, and milk clotting abilities of an aspartic peptidase from Rhizomucor miehei.". Journal of industrial microbiology & biotechnology (2016): https://doi.org/10.1007/s10295-016-1780-4.
    10.1007/s10295-016-1780-4
  22. "Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer.". BMC cancer (2016): http://europepmc.org/articles/PMC4774035.
    10.1186/s12885-016-2203-7
  23. "Cellulolytic and proteolytic ability of bacteria isolated from gastrointestinal tract and composting of a hippopotamus.". AMB Express (2016): http://europepmc.org/articles/PMC4773312.
    10.1186/s13568-016-0188-x
  24. "Analysis of the Specificity and Biochemical Characterization of Metalloproteases Isolated from Eupenicillium javanicum Using Fluorescence Resonance Energy Transfer Peptides.". Frontiers in Microbiology (2016): http://europepmc.org/articles/PMC5220088.
    10.3389/fmicb.2016.02141
  25. "Halotolerant bacteria in the São Paulo Zoo composting process and their hydrolases and bioproducts.". Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2015): http://europepmc.org/articles/PMC4507525.
    10.1590/S1517-838246220130316
  26. "Determination of Specificity and Biochemical Characteristics of Neutral Protease Isolated from Myceliophthora thermophila.". Protein and peptide letters (2015): https://doi.org/10.2174/0929866522666150817093719.
    10.2174/0929866522666150817093719
  27. "Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity.". Biochimica et biophysica acta (2014): https://doi.org/10.1016/j.bbapap.2014.10.018.
    10.1016/j.bbapap.2014.10.018
  28. "The identification and biochemical properties of the catalytic specificity of a serine peptidase secreted by Aspergillus fumigatus Fresenius.". Protein and peptide letters (2014): https://doi.org/10.2174/0929866521666140408114646.
    10.2174/0929866521666140408114646
  29. "Analysis of peptidase activities of a cathepsin B-like (TcoCBc1) from Trypanosoma congolense.". Biochimica et biophysica acta (2014): https://doi.org/10.1016/j.bbapap.2014.04.001.
    10.1016/j.bbapap.2014.04.001
  30. "P-I class metalloproteinase from Bothrops moojeni venom is a post-proline cleaving peptidase with kininogenase activity: insights into substrate selectivity and kinetic behavior.". Biochimica et biophysica acta (2013): https://doi.org/10.1016/j.bbapap.2013.12.014.
    10.1016/j.bbapap.2013.12.014
  31. "Mycoplasma hyopneumoniae in vitro peptidase activities: identification and cleavage of kallikrein-kinin system-like substrates.". Veterinary microbiology (2013): https://doi.org/10.1016/j.vetmic.2013.01.011.
    10.1016/j.vetmic.2013.01.011
  32. "Purification, characterization, and specificity determination of a new serine protease secreted by Penicillium waksmanii.". Applied biochemistry and biotechnology (2012): https://doi.org/10.1007/s12010-012-9974-3.
    10.1007/s12010-012-9974-3
  33. "Correlation between catalysis and tertiary structure arrangement in an archaeal halophilic subtilase.". Biochimie (2011): https://doi.org/10.1016/j.biochi.2011.11.011.
    10.1016/j.biochi.2011.11.011
  34. "Internally quenched fluorescent peptide libraries with randomized sequences designed to detect endopeptidases.". Analytical biochemistry (2011): https://doi.org/10.1016/j.ab.2011.10.025.
    10.1016/j.ab.2011.10.025
  35. "Yellow fever virus NS2B/NS3 protease: hydrolytic properties and substrate specificity.". Biochemical and biophysical research communications (2011): https://doi.org/10.1016/j.bbrc.2011.03.054.
    10.1016/j.bbrc.2011.03.054
  36. "Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition.". Biological chemistry (2010): https://doi.org/10.1515/BC.2010.145.
    10.1515/bc.2010.145
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02/01 - Current ANÁLISE DO SISTEMA CALICREÍNA CININA EM PACIENTES COM COVID-19
Supervisor of Leandro da Silva Fernandes
 nefrologia (Master)
Universidade Federal de São Paulo, Brazil
2023/05 - Current Distúrbios da vascularização placentária ligados a alterações no Sistemas Calicreína-Cinina em gestantes com COVID-19
Supervisor
 Nefrologia (PhD)
Universidade Federal de São Paulo, Brazil
2022 - Current Modulação de marcadores inflamatórios em fibroblastos dérmicos e queratinócitos por inibidores de ECA
Co-supervisor
 Medicina Trasnlacional (PhD)
Universidade Federal de São Paulo, Brazil
2019 - Current CORRELAÇÃO DE METABÓLITOS URINÁRIOS DE PRÉ-PÚBERES E ALTERAÇÕES METABÓLICAS.
Supervisor
 nefrologia (PhD)
Universidade Federal de São Paulo, Brazil
2018 - Current CAPACIDADE DA ANG II E ANG (1-7) DE TRANSLOCAR AQP2 EM CÉLULAS IMCD DO DUCTO COLETOR MEDULAR
Co-supervisor
 Medicina Translacional (PhD)
Universidade Federal de São Paulo, Brazil

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023/12/01 O que são os compostos obesogênicos e como eles afetam sua saúde e seu peso Viva Bem - UOL