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Cláudia Almeida Pires Loureiro graduated in Biotechnology in 2010. She started scientific research during undergraduate training, when she had the opportunity to work at Centro Andaluz de Biologia Molecular y Medicina Regenerativa in Spain, working on a project to understand the consequences of the depletion of leading and lagging strand DNA polymerases in Saccharomyces cerevisae. Since her Master training at the Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA), she has been working on signaling pathways regulating chloride cotransporters and their implications in blood pressure regulation and cystic fibrosis. Her data led to approval of the FCT PIDC/SAU-ORG/119782/2010 project on identification of new signaling pathways involved in the regulation of chloride transport proteins, in which she served as a research fellow after conclusion of her Master degree in Biochemistry at the Faculty of Sciences of University of Lisbon in 2012. Additionally, during this period she collaborated in the host laboratory to explore the role of WNK2 in RAC1 signaling and tumour cell invasion and proliferation (8). In 2014, she obtained a PhD scholarship from FCT under the PhD Programme BioSYS (Biological Systems, Functional & Integrative Genomics), integrated in the BioISI (Biosystems & Integrative Sciences Institute). The PhD project aimed to identify phospho-tyrosine binding proteins by mass spectrometry binding to three different chloride transport proteins (NKCC2, KCC3 and CFTR) and the underlying molecular mechanisms. In 2014 she published her first paper as first author (Loureiro, et al., Sci Signal. 2014) in a high impact factor journal. Based on her PhD work she published 3 more original research papers (Loureiro, et al., Frontiers in Pharmacology 2019; Loureiro, et al., Arch in Biochem and Biophys 2019; Loureiro, et al., Cell Mol. Life Sci. 2020) and co-authored 1 review (Pereira et al., Cell Mol. Life Sci. 2016). After completing her PhD, she had the opportunity to continue as a postdoctoral fellow in the FCT PTDC/BIA-CEL/28408/2017 project to validate new candidate proteins involved in the regulation of chloride transport proteins. Until now she earned an accumulated impact factor of 35,24 and nearly 91 citations (index-h of 3). Moreover, she participated in several national and international scientific meetings, presenting her work as oral or poster communications. She was team member in two research projects with national funding.
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Identification

Personal identification

Full name
Cláudia Almeida Pires Loureiro

Citation names

  • Loureiro, C.A.
  • Loureiro, CA
  • Loureiro, Claudia A.

Author identifiers

Ciência ID
531C-114A-F7A7
ORCID iD
0000-0002-6969-3285

Email addresses

  • loualmclaudia@gmail.com (Professional)

Addresses

  • Campo Grande, edifício C1, 3.º piso, 1749-016 , Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Advanced (C1) Upper intermediate (B2)
French Elementary (A2) Elementary (A2) Beginner (A1) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
2014/01/01 - 2019/05/04
Concluded
 Doutoramento em Biologia (Doutoramento)
Major in Biologia de Sistemas
Universidade de Lisboa Faculdade de Ciências, Portugal
"Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks" (THESIS/DISSERTATION)
2016/04/11 - 2016/04/15
Concluded
 Course PDA16- Proteomics Data Analysis (Outros)
Instituto Gulbenkian de Ciência, Portugal
2016/02/28 - 2016/03/05
Concluded
 6th Advanced Lecture Course on System Biology (Outros)
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Switzerland
2012
Concluded
 Mestrado em Bioquímica (Mestrado)
Major in Especialização em Bioquímica Médica
Universidade de Lisboa Faculdade de Ciências, Portugal
"A new WNK4/Syk signalling pathway regulating chloride channel membrane levels in kidney cells" (THESIS/DISSERTATION)
 16
2006/09/01 - 2010/09/30
Concluded
 Biotecnologia (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
" Consequences of the depletion of leading and lagging strand DNA polymerases " (THESIS/DISSERTATION)
 12
Affiliation

Others

Category
Host institution 		Employer
2019/08/04 - 2020/07/30 Post-doctoral fellow FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2014/01/01 - 2019/01/31 PhD student Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
(...)
2012/02/01 - 2013/12/31 Research fellow Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
(...)
2011/09/01 - 2012/08/31 Master undergraduate internship Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/02/01 - 2010/06/30 Degree undergraduate internship Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
Projects

Grant

Designation Funders
2019/08/04 - 2020/07/31 New signaling pathways involved in the regulation of chloride transport proteins
PTDC/BIA-CEL/28408/2017
Post-doc Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014/01/01 - 2019/03/31 Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks
SFRH/BD/52488/2014
PhD Student Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/02/01 - 2013/12/31 A novel signaling pathway possibly involved in renal salt handling and hypertension
PIDC/SAU-ORG/119782/2010
Research Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Loureiro, C.A. (531C-114A-F7A7); Barros, P.; Pinto, F. (C911-208F-9F71); Matos, P. (0F14-CA4F-1358); Jordan, P.. "A novel SYK/SHC1 pathway regulating the amount of CFTR in the plasma membrane". Paper presented in 10th Meeting in Signal Transduction, 2019.
  2. Loureiro, C.A. (531C-114A-F7A7); Barros, P.; Matos, P (0F14-CA4F-1358); Jordan, P.; Pinto, F. (C911-208F-9F71). "Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3". Paper presented in 6th meeting of the International Society of Cancer Metabolism (ISCaM), 2019.
  3. Loureiro, C.A. (531C-114A-F7A7); Matos, P. (0F14-CA4F-1358); Jordan, P.. "Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks". Paper presented in SINAL– 8th National Meeting on Signal Transduction, 2017.
  4. Loureiro, C.A. (531C-114A-F7A7); Matos, P. (0F14-CA4F-1358); Jordan, P.. "Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks.". Paper presented in Day of the young investigator of Instituto de Saúde Doutor Ricardo Jorge, 2017.
  5. Loureiro, C.A. (531C-114A-F7A7); Clarke, L.; Jordan, P.. "Regulation of epithelial chloride transport by tyrosine phosphorylation". Paper presented in 6th Advanced Lecture Course on Systems Biology,, 2016.
  6. Loureiro, C.A. (531C-114A-F7A7); Jordan, P.. "Regulation of epithelial chloride transport by tyrosine phosphorylation". Paper presented in 40th Congress of The Federation European Biochemical Societies, 2015.
  7. Loureiro, C.A. (531C-114A-F7A7); Jordan, P.. "A new WNK4/Syk signaling pathway regulating membrane levels of chloride co-transporters in kidney cell". Paper presented in SINAL- 7nd National Meeting on Signal Transduction, 2013.
  8. Loureiro, C.A. (531C-114A-F7A7); Jordan, P.. "A new WNK4/Syk signaling pathway regulating chloride channel membrane levels in kidney cells". Paper presented in 2nd Meeting of the Health Molecular Biology, 2012.
Journal article
  1. Loureiro, C.A. (531C-114A-F7A7); Pinto, F.R.; Barros, P.; Matos, P. (0F14-CA4F-1358); Jordan, P. "A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane". Cellular and Molecular Life Sciences (2020): http://dx.doi.org/10.1007/s00018-020-03448-4.
    10.1007/s00018-020-03448-4
  2. Loureiro, C.A. (531C-114A-F7A7); Barros, P.; Matos, P. (0F14-CA4F-1358); Jordan, P.. "Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3". Archives of Biochemistry and Biophysics 669 (2019): 61-70. http://dx.doi.org/10.1016/j.abb.2019.05.022.
    10.1016/j.abb.2019.05.022
  3. Loureiro, C.A. (531C-114A-F7A7); Santos, J. D.; Matos, A.M.; Jordan, P.; Matos, P. (0F14-CA4F-1358); Farinha, C.M. (DC12-585B-127E); Pinto, F.R. (C911-208F-9F71). "Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability". Frontiers in Pharmacology 10 (2019): http://dx.doi.org/10.3389/fphar.2019.00619.
    10.3389/fphar.2019.00619
  4. Pereira, J. F. S. (F91B-46F6-AFA4); Awatade, N. T.; Loureiro, C.A. (531C-114A-F7A7); Matos, P. (0F14-CA4F-1358); Amaral, M.D.; Jordan, P.. "The third dimension: new developments in cell culture models for colorectal research". Cellular and Molecular Life Sciences 73 21 (2016): 3971-3989. http://dx.doi.org/10.1007/s00018-016-2258-2.
    10.1007/s00018-016-2258-2
  5. Loureiro, C.A. (531C-114A-F7A7); Matos, A.M.; Dias-Alves, A.; Pereira, J.F.; Uliyakina, I.; Barros, P.; Amaral, M.D.; Matos, P.. "A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint". Science Signaling 8 377 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929667112&partnerID=MN8TOARS.
    10.1126/scisignal.aaa1580
  6. Moniz, S.; Martinho, O.; Pinto, F.; Sousa, B.; Oliveira, M.J.; Moita, L.F.; Honavar, M.; et al. "Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness". Human Molecular Genetics 22 1 (2013): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871200220&partnerID=MN8TOARS.
    10.1093/hmg/dds405
Thesis / Dissertation
  1. Loureiro, CA. "Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks". PhD, Universidade de Lisboa Faculdade de Ciências, 2019.
  2. Loureiro, CA. "A new WNK4/Syk signalling pathway regulating chloride channel membrane levels in kidney cells". Master, 2012.
  3. Loureiro, CA. "Consequences of the depletion of leading and lagging strand DNA polymerases". Degree, 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10/18 A novel SYK/SHC1 pathway regulating the amount of CFTR in the plasma membrane 10th Meeting in Signal Transduction
(Olhão, Portugal)
2019/09/12 Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks Seminars of Department of Genetics, Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA)
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2017/05/08 Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks Young investigator day of Instituto de Saúde Doutor Ricardo Jorge
Instituto de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2016/07/22 Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks. 1st BioSys Retreat
BioISI (Santa Cruz, Torres Vedras, Portugal., Portugal)
2015/07/02 Regulation of epithelial chloride transport by tyrosine phosphorylation 15th FEBS Young Scientists’ Forum
FEBS (Berlim, Germany)
2013/01/24 A new WNK4/Syk signaling pathway regulating chloride channel, NKCC2, involved in hypertension. XIV Portuguese Congress of Endocrinology
(Porto, Portugal)
Distinctions

Other distinction

2019 Post-doctoral Fellow granted by FCiências.ID on the project PTDC/BIA-CEL/28408
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
2015 FEBS Youth Travel Grant
Federation of European Biochemical Societies, United Kingdom
2014 PhD scholarship granted by PhD Programme BioSys-Biological Systems, Functional & Integrative Genomics
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2012 Research Fellow on the project A novel signalling pathway possibly involved in renal salt handling and hypertension, PTDC/SAU-ORG/119782/2010
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal