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Dr. Dora Costa was born in Vila Nova de Famalicão in 1987. She completed her BSc in Biochemistry in 2009 and her MSc in Chemistry (specialization in Organic Chemistry and Natural Products) in 2011, both from University of Aveiro. At February of 2019, She got her PhD degree from Universidade Federal Fluminense (Niterói, RJ, Brazil). She published 30 articles in international journals, 1 book chapter. She also has 8 patents (3 of them granted).
Identification

Personal identification

Full name
Dora Cristina Silva Costa

Citation names

  • D.C.S. Costa
  • Dora C.S. Costa
  • Costa, D.C.S.

Author identifiers

Ciência ID
531E-D688-9D8C
ORCID iD
0000-0002-5634-6743
Scopus Author Id
57194652108

Email addresses

  • doracosta@ua.pt (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences - Biological Sciences - Biochemistry
  • Engineering and Technology - Materials Engineering - Materials Engineering
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2015/03/23 - 2019/02/22
Concluded
 Chemistry (Doctor)
Universidade Federal Fluminense Instituto de Química, Brazil
"Synthesis, methodological study and biological evaluation of new naphthoquinone derivatives" (THESIS/DISSERTATION)
2009/09/01 - 2011/12/20
Concluded
 Chemistry: Organic Chemistry and Natural Products (Mestrado)
Universidade de Aveiro, Portugal
"Synthesis and biological evaluation of new porphyrin derivatives (Final grade: 17/20)" (THESIS/DISSERTATION)
 15 (fifteen)
2005/09/19 - 2009/07/29
Concluded
 Biochemistry (Licenciatura)
Universidade de Aveiro, Portugal
"Photoinactivation of Emerging Microbials in Burned patients (Final grade: 17/20)" (THESIS/DISSERTATION)
 13 (thirteen)
Affiliation

Science

Category
Host institution 		Employer
2019/11/15 - 2024/08/31 Contracted Researcher (Research) Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro CICECO, Portugal
2019/05/02 - 2019/11/14 Postdoc (Research) Universidade de Aveiro CICECO, Portugal
2014/09/01 - 2015/01/31 Researcher (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2012/08/16 - 2014/08/15 Researcher (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2011/07/04 - 2012/06/19 Researcher (Research) Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Projects

Grant

Designation Funders
2023/04/01 - 2024/08/31 Merging Sustainable and Digital Chemical Technologies for the Development the Greener-By-Design Pharmaceuticals. (Suspharma)
HORIZON-HLTH-2021-IND-07: 101057430
Researcher
Universidade de Aveiro, Portugal
 European Commission
Ongoing
2022/09/01 - 2024/08/31 Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering (REBORN)
H2020-ERC-AdG: 883370
Researcher
Universidade de Aveiro, Portugal
 European Research Council
Ongoing
2019/11 - 2022/07/25 Engineering of marine-inspired highperformance multifunctional hydrogels for cartilage regeneration crosslinked with bioinstructive and sliding non-covalent bonds (MARGEL)
PTDC/BTM-MAT/31498/2017
Co Prinicipal Investigator
Universidade de Aveiro CICECO, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/05/02 - 2019/11/14 Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine (ATLAS)
ERC-2014-AdG:669858
Post-doc Fellow
Universidade de Aveiro CICECO, Portugal
 European Research Council
Concluded
2014/09 - 2015/01 Synthesis of thiazolidine derivatives from cysteine and penicillamine: new ligands for the enantioselective alkylation of aldehydes
UI0117/QUI/UI0113/2014
Research Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/08 - 2014/08 AMILOTERA: Development and optimization of therapeutic agents against amyloid diseases by transthyretin
QREN 2011/021622
Research Fellow
N/A
Concluded
2011/07 - 2012/06 Nanocages and "bio"-polymers for recognition and solubilization of carbon nanotubes
PTDC/QUI/65228/2006
Research Fellow
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/09 - 2024/08/31 Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering (REBORN)
H2020_ERC_AdG 883370
Universidade de Aveiro CICECO, Portugal
 European Research Council
Ongoing
2021/01/01 - 2024/08/31 CICECO - Aveiro Institute of Materials
LA/P/0006/2020
Universidade de Aveiro CICECO, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/11/15 - 2022/07/25 Engineering of marine-inspired high-performance multifunctional hydrogels for cartilage regeneration crosslinked with bioinstructive and sliding non-covalent bonds (MARGEL)
PTDC/BTM-MAT/31498/2017
Researcher
Universidade de Aveiro CICECO, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Rodrigues, J. M. M.; Castanheira, E. J.; Costa, D. C. S.; Rocha, D. H. A.; Borges, J.; Mano, J. F.. "Chapter 8. Extending the Functionality of Marine-origin Polysaccharides Through Chemical Modification for Biomedical Applications". In Soft Matter for Biomedical Applications, edited by João F. Mano; Helena S. Azevedo; João Borges, 180-204. Royal Society of Chemistry, 2021.
    Published • 10.1039/9781839161124-00180
Conference abstract
  1. Ana R. Pinho; Dora C.S. Costa; Maria C. Gomes; João F. Mano. "From Protein-Based Liquified Microcapsules To Bone Tissue Micro-Units". Paper presented in Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022, Krakow, 2022.
    Published
Conference poster
  1. de Souza, Acácio S.; Dias, Deborah S.; Ribeiro, Ruan C. B.; Costa, Dora C. S.; Marins, Laís M.; de Moraes, Matheus G.; Valle, Sandy P.; et al. "Naphthoquinone-1H-1,2,3-triazole Hybrids: Design, Synthesis and Evaluation as Inductors of ROS-Mediated Apoptosis in the MCF-7 Cells". Paper presented in 47ª Reunião Anual da Sociedade Brasileira de química (RASBQ), 2024.
  2. Ana Rita Pinho; Costa, D.C.S.; Mara Clara Gomes. "Catechol analogs' many roles in the multifunctionality of liquid gelatine-based capsules". Paper presented in SUPRALIFE Second School - "Bioinspired Supramolecular Self-Assemblies", 2024.
  3. Pinho, Ana Rita; Dora C.S. Costa; Maria C. Gomes; Mano, Joao F.. "Bone liquified microunits as an innovative strategy to promote bone tissue regeneration". Paper presented in Jornadas CICECO 2022, 2022.
  4. Milena Diniz Lessa; Maicon Delarmelina; Dora C.S. Costa; José Walkimar de Mesquita Carneiro; da Silva, Fernando de Carvalho; F. Ferreira, Vitor; da S. M. Forezi, Luana; et al. "Insights From DFT Analysis Into Palladium-Catalyzer Heck Coupling Between 3-Bromo-2-Methoxylawsone And 1H-1,2,3-Triazoles Derivatives". Paper presented in XXI Simpósio Brasileiro de Química Teórica (SBQT), 2021.
  5. Ana Rita Pinho; Dora C.S. Costa; Maria Clara Gomes; João F. Mano. "Protein-based liquified systems: a step closer to personalized medicine". Paper presented in 4th International Conference on Biomimetics and Bioadhesives 2021, 2021.
  6. Danielle Pagliaminuto Portella; Daniel Tadeu Gomes Gonzaga; Dora C.S. Costa; da Silva, Fernando de Carvalho; Danielle Montenegro da Surreição; Vitor F. Ferreira; Maria Eduarda L. de Lima. "Synthesis of 1H-1,2,3-triazoles conjugated to the thiophene nucleus with potential anti-inflammatory activity". Paper presented in 43rd Annual Meeting (Virtual) of the Brazilian Chemical Society, 2020.
  7. Tavares, Nélia C. T.; Dora C.S. Costa; Murtinho, D.; Serra, Maria Elisa Silva. "Synthesis and Catalytic Application of Thiazolidines in Enantioselective Reactions with Zinc Reagents". Paper presented in International School of Organometallic Chemistry, 2019.
  8. D.C.S. Costa; Gabriella S. Almeida; Vitor W.-H. Rabelo; Lucio M. Cabral, Plínio C. Sathler; Paula A. Abreu; Vitor F. Ferreira; Luiz C.R.P. Silva; Fernando C. Silva. "Síntese e avaliação da atividade citotóxica de furanonaftoquinonas acopladas a 1H-1,2,3-Triazois frente a células de Caco-2, Calu-3, MDA-MB231". Paper presented in VII Annual Meeting of students of the PPGQ – UFF, 2018.
  9. D.C.S. Costa; Gabriella S. Almeida; Vitor W.-H. Rabelo; Lucio M. Cabral; Plínio C. Sathler; Paula A. Abreu; Vitor F. Ferreira; Luiz C.R.P. da Silva; Fernando C. Silva. "Synthesis and Evaluation of the Cytotoxic Activity of Furanaphthoquinones Tethered to 1H-1,2,3-Triazoles in Caco-2, Calu-3, MDA-MB231 Cells". Paper presented in 17th Brazilian Meeting of Organic Chemistry (17th BMOS), 2018.
  10. Juliana V. Bernardo; Dora C.S. Costa; Fernando C. Silva; Marcela C. Moraes. "Estudo de novos derivados 1H-1,2,3-triazol da quinacrina como potenciais moduladores da agregação da proteína príon". Paper presented in V Annual Meeting of students of the PPGQ – UFF, 2016.
  11. Luana S.M. Forezi; D.C.S. Costa; Vitor F. Ferreira; Fernando C. Silva. "Síntese de (E)-2-hidroxi-3-(2-(1-fenil-1H-1,2,3-triazl-4-il)vinil)-1,4-naftoquinona via acoplamento de Heck". Paper presented in 39th Annual Meeting of the Brazilian Chemical Society, 2016.
  12. Tavares, Nélia C. T.; Serra, Maria Elisa Silva; Dora C.S. Costa; Murtinho, D.; Teresa M. V. D. Pinho e Melo. "Thiazolidine Catalysts Derived From D-Penicillamine and L-Cysteine: An Efficient Approach to Both Enantiomers of Secondary Alcohols". Paper presented in 5th Portuguese Young Chemists Meeting and 1st European Young Chemists Meeting, 2016.
  13. Serra, Maria Elisa Silva; Dora C.S. Costa; Murtinho, Dina; Teresa M.V.D. Pinho E Melo. "D-Penicillamine and L-Cysteine-Derived Thiazolidine Catalysts: An Efficient Approach To Both Enantiomers of Secondary Alcohols". Paper presented in Congresso Química Orgânica e Química Terapêutica, 2015.
  14. D.C.S. Costa; Maria E.S. Serra; Dina Murtinho. "Design and Synthesis of ligands for Asymmetric Catalysis and Biological Studies". Paper presented in The Chemistry Centre Day 2014, 2014.
  15. Carlos J.V. Simões; Bruno L. Victor; D.C.S. Costa; Bruno Nascimento; Zaida Almeida; Ana L. Cardoso; Teresa Pinho e Melo; Rui M. M. Brito. "AMILOTERA - Discovery and optmization of novel therapeutic agents against transthyretyn-related amyloid diseases". Paper presented in Young Researchers Meeting of Computational Structural Biology, 2013.
  16. Flávio Figueira; Clara Gomes; D.C.S. Costa; João Rodrigues; Sandrina Silva; Patricia Pereira; Andreia Farinha; José Abrunheiro da Silva Cavaleiro; João Paulo Costa Tomé. "Synthesis of Porphyrins and Analogues for Photomedicinal and Environmental Applications". Paper presented in 2nd Research Day, Univeristy of Aveiro, 2012.
  17. D.C.S. Costa; Vânia F. Pais; Artur M.S. Silva; José A.S. Cavaleiro; Uwe Pischel; João P.C. Tomé. "Pyridinium porphyrins and their host-guest interactions with cucurbituril macrocycles". Paper presented in 3rd Portuguese Young Chemists Meeting (PYCHEM 2012), 2012.
  18. D.C.S. Costa; Maria A.F. Faustino; Maria G.P.M.S. Neves; José A.S. Cavaleiro; João P.C. Tomé. "Synthesis and Photophysical Studies of Pyridinium Porphyrin and Chlorin Derivatives". Paper presented in 22nd SPQ National Meeting, 2011.
  19. D.C.S. Costa; Daniela A. Alves; Carla M.B. Carvalho; João P.C. Tomé; Augusto C. Tomé; Maria G.P.M.S. Neves; Maria A.F. Faustino; et al. "Synthesis and biological evaluation of new water-soluble porphyrins". Paper presented in 8th National Meeting on Organic Chemistry, 2009.
Journal article
  1. Esteves, Priscilla O.; Cirne-Santos, Claudio C.; Barros, Caroline S.; Gomes, Max W.L.; Alves, Guilherme; Rabelo, Vitor Won-Held; Portella, Danielle P.; et al. "Synthesis and evaluation of the activity of 1H-1,2,3-triazole-thiophene ester derivatives against Chikungunya virus". The Microbe (2024): 100220. https://doi.org/10.1016/j.microb.2024.100220.
    10.1016/j.microb.2024.100220
  2. Ornellas, Brenda Bairral Queiroz; de Oliveira, Eduardo Coriolano; Junior, Luiz Carlos Simas Pereira; Sanchez, Eladio Flores; Dora C.S. Costa; Portella, Danielle Pagliaminuto; da Silva, Fernando de Carvalho; et al. "Designing 1,2,3-Triazole Derivatives for Targeted Inhibition of Proteolytic and Coagulant Activities in Bothrops Jararaca and Bothrops neuwiedi Snake Venoms". ChemistrySelect 9 41 (2024): http://dx.doi.org/10.1002/slct.202400061.
    10.1002/slct.202400061
  3. Dora C.S. Costa; Froes, Thamires Quadros; Mendes, Marina; da S. M. Forezi, Luana; Ferreira, Vitor; Castilho, Marcelo Santos; de C. da Silva, Fernando. "1H-1,2,3-triazol-1,4-naphthoquinone Derivatives: Novel Inhibitors Targeting Pyocyanin Biosynthesis for P. Aeruginosa Infection TreatmentAdvances". Current Topics in Medicinal Chemistry 24 24 (2024): 2161-2171. http://dx.doi.org/10.2174/0115680266327024240726111230.
    10.2174/0115680266327024240726111230
  4. de Souza, Acácio S.; Dias, Deborah S.; C. B. Ribeiro, Ruan; Dora C.S. Costa; de Moraes, Matheus G.; Pinho, David R.; E. G. Masset, Maria; et al. "Novel Naphthoquinone-1H-1,2,3-triazole Hybrids: Design, Synthesis and Evaluation as Inductors of ROS-Mediated Apoptosis in the MCF-7 Cells". Bioorganic & Medicinal Chemistry 102 (2024): 117671. http://dx.doi.org/10.1016/j.bmc.2024.117671.
    Published • 10.1016/j.bmc.2024.117671
  5. Machado Fernandes, Caio; Lessa, Renato C.S.; Dora C.S. Costa; Guedes, Lucas; Martins, Vinicius; Al-Rashdi, Awad A.; Francisco Ferreira, Vitor; et al. "Experimental and theoretical evaluation of the anticorrosive proprieties of new 1,2,3-triazolyl-acridine derivatives". Arabian Journal of Chemistry 17 1 (2024): 105401. http://dx.doi.org/10.1016/j.arabjc.2023.105401.
    10.1016/j.arabjc.2023.105401
  6. Pinho, Ana R.; Gomes, Maria C.; Costa, Dora C. S.; Mano, João F.. "Bioactive Self-Regulated Liquified Microcompartments to Bioengineer Bone-Like Microtissues". Small (2023): 2305029. http://dx.doi.org/10.1002/smll.202305029.
    Published • 10.1002/smll.202305029
  7. Amaral, Katia R.; Silva, A. Sofia; Santos, Lúcia F.; Castanheira, Edgar J.; Mendes, Maria C.; Costa, Dora C.S.; Rodrigues, João M. M.; Marto, Joana; Mano, João F.. "Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release". Advanced Healthcare Materials 12 28 (2023): 2301513. http://dx.doi.org/10.1002/adhm.202301513.
    Published • 10.1002/adhm.202301513
  8. Ouro, Pedro M.S.; Costa, Dora C.S.; Amaral, Adérito J.R.; Mano, João F.. Corresponding author: Costa, Dora C.S.. "A Supramolecular Injectable Methacryloyl Chitosan-Tricine-Based Hydrogel with 3D Printing Potential for Tissue Engineering Applications". Macromolecular Bioscience 24 1 (2023): 2300058. http://dx.doi.org/10.1002/mabi.202300058.
    Published • 10.1002/mabi.202300058
  9. Rial-Hermida, M. Isabel; Costa, Dora C. S.; Jiang, Lan; Rodrigues, João M. M.; Ito, Kohzo; Mano, João F.. "Bioinspired Oxidation-Resistant Catechol-like Sliding Ring Polyrotaxane Hydrogels". Gels 9 2 (2023): 85. http://dx.doi.org/10.3390/gels9020085.
    Published • 10.3390/gels9020085
  10. Mortier, C.; Dora C.S. Costa; Oliveira, M.B.; Haugen, H.J.; Lyngstadaas, S.P.; Blaker, J.J.; Mano, J.F.. Corresponding author: Dora C.S. Costa. "Advanced hydrogels based on natural macromolecules: chemical routes to achieve mechanical versatility". Materials Today Chemistry 26 (2022): 101222. http://dx.doi.org/10.1016/j.mtchem.2022.101222.
    10.1016/j.mtchem.2022.101222
  11. Costa, Dora C. S.; da S. M. Forezi, Luana; Lessa, Milena D.; Delarmelina, Maicon; Matuck, Beatriz V. A.; Freitas, Maria Clara R.; Ferreira, Vitor F.; et al. "A Stereoselective, Base-free, Palladium-Catalyzed Heck Coupling Between 3-halo-1,4-Naphthoquinones and Vinyl-1H-1,2,3-Triazoles". ChemistrySelect 7 24 (2022): e202201334. http://dx.doi.org/10.1002/slct.202201334.
    10.1002/slct.202201334
  12. de Souza, Acácio S; Ribeiro, Ruan Carlos B; Costa, Dora C S; Pauli, Fernanda P; Pinho, David R; de Moraes, Matheus G; da Silva, Fernando de C; Forezi, Luana da S M; Ferreira, Vitor F. "Menadione: a platform and a target to valuable compounds synthesis". Beilstein Journal of Organic Chemistry 18 (2022): 381-419. http://dx.doi.org/10.3762/bjoc.18.43.
    Published • 10.3762/bjoc.18.43
  13. Costa, Dora C. S.; Costa, Patrícia D. C.; Gomes, Maria C.; Chandrakar, Amit; Wieringa, Paul A.; Moroni, Lorenzo; Mano, João F.. Corresponding author: Costa, Dora C. S.. "Universal Strategy for Designing Shape Memory Hydrogels". ACS Materials Letters 4 (2022): 701-706. http://dx.doi.org/10.1021/acsmaterialslett.2c00107.
    10.1021/acsmaterialslett.2c00107
  14. Costa, Dora; Francisco, Adriane; Matuck, Beatriz; Furtado, Priscila; de Oliveira, Alana; Rabelo, Vitor; Sathler, Plínio; et al. "Diacetate Naphthoquinone Derivatives Tethered to 1,2,3-Triazoles: Synthesis and Cytotoxicity Evaluation in Caco-2 Cells". Journal of the Brazilian Chemical Society 33 1 (2022): 48-59. http://dx.doi.org/10.21577/0103-5053.20210123.
    10.21577/0103-5053.20210123
  15. Tavares, Nélia C. T.; Cacho, Vanessa R. G.; Costa, Dora C. S.; Nunes, Sandra C. C.; Pais, Alberto A. C. C.; Murtinho, Dina; Silva Serra, M. Elisa. "Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine-based amino alcohols". Applied Organometallic Chemistry 36 3 (2021): e6567. http://dx.doi.org/10.1002/aoc.6567.
    10.1002/aoc.6567
  16. Gomes, Maria C.; Costa, Dora C. S.; Oliveira, Cláudia S.; Mano, João F.. "Design of Protein-Based Liquefied Cell-Laden Capsules with Bioinspired Adhesion for Tissue Engineering". Advanced Healthcare Materials 10 19 (2021): 2100782. http://dx.doi.org/10.1002/adhm.202100782.
    10.1002/adhm.202100782
  17. Costa, Patrícia D. C.; Costa, Dora C. S.; Correia, Tiago R.; Gaspar, Vítor M.; Mano, João F.. Corresponding author: Costa, Dora C. S.. "Natural Origin Biomaterials for 4D Bioprinting Tissue-Like Constructs". Advanced Materials Technologies 6 10 (2021): 2100168. http://dx.doi.org/10.1002/admt.202100168.
    10.1002/admt.202100168
  18. André, Lialyz Soares Pereira; Pereira, Renata Freire Alves; Pinheiro, Felipe Ramos; Pascoal, Aislan Cristina Rheder Fagundes; Ferreira, Vitor Francisco; de Carvalho da Silva, Fernando; Gonzaga, Daniel Tadeu Gomes; et al. "Biological Evaluation of Selected 1,2,3-triazole Derivatives as Antibacterial and Antibiofilm Agents". Current Topics in Medicinal Chemistry 20 24 (2020): 2186-2191. http://dx.doi.org/10.2174/1568026620666200710104737.
    10.2174/1568026620666200710104737
  19. Lima, Carolina G. S.; Pauli, Fernanda P.; Costa, Dora C. S.; de Souza, Acácio S.; Forezi, Luana S. M.; Ferreira, Vitor F.; de Carvalho da Silva, Fernando. "para -Quinone Methides as Acceptors in 1,6-Nucleophilic Conjugate Addition Reactions for the Synthesis of Structurally Diverse Molecules". European Journal of Organic Chemistry 2020 18 (2020): 2650-2692. http://dx.doi.org/10.1002/ejoc.201901796.
    Published • 10.1002/ejoc.201901796
  20. Cristina Silva Costa, Dora. Corresponding author: Cristina Silva Costa, Dora. "Additions to non-activated alkenes: Recent advances". Arabian Journal of Chemistry 13 1 (2020): 799-834. http://dx.doi.org/10.1016/j.arabjc.2017.07.017.
    10.1016/j.arabjc.2017.07.017
  21. Filho, Ricardo Imbroisi; Gonzaga, Daniel T.G.; Demaria, Thainá M.; Leandro, João G.B.; Costa, Dora C.S.; Ferreira, Vitor F.; Sola-Penna, Mauro; de C. da Silva, Fernando; Zancan, Patricia. "A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties". Current Topics in Medicinal Chemistry 18 17 (2018): 1483-1493. http://dx.doi.org/10.2174/1568026618666180917100640.
    10.2174/1568026618666180917100640
  22. Costa, Dora C.S.; de Almeida, Gabriella Silva; Rabelo, Vitor Won-Held; Cabral, Lucio Mendes; Sathler, Plínio Cunha; Alvarez Abreu, Paula; Ferreira, Vitor Francisco; Cláudio Rodrigues Pereira da Silva, Luiz; da Silva, Fernando de C.. "Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells". European Journal of Medicinal Chemistry 156 (2018): 524-533. http://dx.doi.org/10.1016/j.ejmech.2018.07.018.
    10.1016/j.ejmech.2018.07.018
  23. da S.M. Forezi, Luana; Froes, Thamires Quadros; Cardoso, Mariana F.C.; de Oliveira Maciel, Carine Assuncao; Nicastro, Gianluca G.; Baldini, Regina L.; Costa, Dora C.S.; et al. "Synthesis and Biological Evaluation of Coumarins Derivatives as Potential Inhibitors of the Production of Pseudomonas aeruginosa Virulence Factor Pyocyanin". Current Topics in Medicinal Chemistry 18 2 (2018): 149-156. http://dx.doi.org/10.2174/1568026618666180329122704.
    10.2174/1568026618666180329122704
  24. Lopes, Susana M.M.; Novais, Juliana S.; Costa, Dora C.S.; Castro, Helena C.; Figueiredo, Agnes Marie S.; Ferreira, Vitor F.; Pinho e Melo, Teresa M.V.D.; da Silva, Fernando de Carvalho. "Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile". European Journal of Medicinal Chemistry 143 (2018): 1010-1020. http://dx.doi.org/10.1016/j.ejmech.2017.11.052.
    10.1016/j.ejmech.2017.11.052
  25. Costa, Dora C.S.; Forezi, Luana S. M.; Cardoso, Mariana F. C.; Ribeiro, Ruan C. B.; Pinto, Angelo C.; Ferreira, Vitor F.; da Silva, Fernando de C.. "A Compendium of Tyrosine-kinase Inhibitors: Powerful and Efficient Drugs against Cancer". Revista Virtual de Química 9 3 (2017): 974-1064. http://dx.doi.org/10.21577/1984-6835.20170063.
    10.21577/1984-6835.20170063
  26. Forezi, L.S.M.; Cardoso, M.F.C.; Costa, D.C.S.; da Silva, F.C.; Ferreira, V.F.; da S. M. Forezi, Luana; Cardoso, Mariana F. C.; et al. "2,3-dichloro-1,4-naphthoquinone in organic synthesis: Recent advances". Mini-Reviews in Organic Chemistry 14 5 (2017): 375-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033229308&partnerID=MN8TOARS.
    10.2174/1570193X14666170518125507
  27. Simões, Carlos J.V.; Almeida, Zaida L.; Costa, Dora; Jesus, Catarina S.H.; Cardoso, Ana L.; Almeida, Maria R.; Saraiva, Maria J.; Pinho e Melo, Teresa M.V. D.; Brito, Rui M.M.. "A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition". European Journal of Medicinal Chemistry 121 (2016): 823-840. http://dx.doi.org/10.1016/j.ejmech.2016.02.074.
    10.1016/j.ejmech.2016.02.074
  28. Serra, M. Elisa Silva; Costa, Dora; Murtinho, Dina; Tavares, Nélia C.T.; Pinho e Melo, Teresa M.V.D.. "d-Penicillamine and l-cysteine derived thiazolidine catalysts: an efficient approach to both enantiomers of secondary alcohols". Tetrahedron 72 39 (2016): 5923-5927. http://dx.doi.org/10.1016/j.tet.2016.08.036.
    10.1016/j.tet.2016.08.036
  29. Costa, Dora C.S.; Pais, Vânia F.; Silva, Artur M.S.; Cavaleiro, José A.S.; Pischel, Uwe; Tomé, João P.C.. "Cationic porphyrins with inverted pyridinium groups and their fluorescence properties". Tetrahedron Letters 55 30 (2014): 4156-4159. http://dx.doi.org/10.1016/j.tetlet.2014.05.108.
    10.1016/j.tetlet.2014.05.108
  30. Costa, Dora C. S.; Gomes, Maria C.; Faustino, Maria A. F.; Neves, Maria G. P. M. S.; Cunha, Ângela; Cavaleiro, José A. S.; Almeida, Adelaide; Tomé, João P. C.. "Comparative photodynamic inactivation of antibiotic resistant bacteria by first and second generation cationic photosensitizers". Photochemical & Photobiological Sciences 11 12 (2012): 1905. http://dx.doi.org/10.1039/c2pp25113b.
    10.1039/c2pp25113b
Thesis / Dissertation
  1. D.C.S. Costa. "Síntese, estudo metodológico e avaliação biológica de novos derivados naftoquinônicos. (English title: Synthesis, methodological study and biological evaluation of new naphthoquinone derivatives¿)". PhD, Universidade Federal Fluminense Instituto de Química, 2019.
  2. D.C.S. Costa. "Síntese e avaliação biológica de novos derivados porfirínicos. (English title: “Synthesis and biological evaluation of new porphyrin derivatives”)". Master, Universidade de Aveiro Departamento de Química, 2011.
  3. D.C.S. Costa. "Fotoinactivação de Microrganismos Emergentes Isolados de Doentes Queimados. (English title: “Photoinactivation of Isolated Emerging Microbials in Burned patients”)". Degree, Universidade de Aveiro Departamento de Química, 2009.

Intellectual property

Patent
  1. João Filipe Colardelle Da Luz Mano; Mariana Braga de Oliveira; Ana María Santos Coquillat; Dora C.S. Costa. 2023. "Hydrogels made of cell secretomes, production method and uses thereof (PT119101)". Portugal.
    Pending
  2. João Filipe Colardelle Da Luz Mano; Dora C.S. Costa; Maria Isabel Rial Hermida; João Manuel Marques Rodrigues. 2022. "Hidrogéis Bioinspirados À Base De Polirotaxanos Deslizantes Funcionalizados Com Análogos De Catecóis, Processos De Produção E Suas Aplicações (PT118101)". Portugal.
    Pending
  3. Carlos J.V. Simões; Zaida C.L. Almeida; Teresa M.V.D. Pinho E Melo; Dora C.S. Costa; Ana L.C.C. Lopes; Rui M.P.M.F Brito. 2021. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) (PT3307723T)". Portugal.
    Allowed
  4. Zaida C.L. Almeida; Ana L.C.C. Lopes; Rui M.P.M.F Brito; Dora C.S. Costa; Teresa M.V.D. Pinho E Melo; Carlos J.V. Simões. 2021. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) (DK3307723T3)". Denmark.
    Granted/Issued
  5. Carlos J.V. Simões; Zaida C.L. Almeida; Teresa M.V.D. Pinho E Melo; Rui M.P.M.F Brito; Dora C.S. Costa; Ana L.C.C. Lopes. 2020. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) (EP3307723B1)".
    Granted/Issued
  6. Carlos J.V. Simões; Zaida C.L. Almeida; Teresa M.V.D. Pinho E Melo; Rui M.P.M.F Brito; Dora C.S. Costa; Ana L.C.C. Lopes. 2019. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) (US10377729B2)". United States.
    Granted/Issued
  7. Ana L.C.C. Lopes; Carlos J.V. Simões; Dora C.S. Costa; Rui M.P.M.F Brito; Teresa M.V.D. Pinho E Melo; Zaida C.L. Almeida. 2019. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) (BR112017027205A2)". Brazil.
    Allowed
  8. Carlos J.V. Simões; Zaida C.L. Almeida; Teresa M.V.D. Pinho E Melo; Rui M.P.M.F Brito; Dora C.S. Costa; Ana L.C.C. Lopes. 2016. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) (WO2016203402A1)".
    Allowed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/07 From protein-based liquified microcapsules to bone tissue micro-units Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022
(Krakow, Poland)
2021/11 Bioinspired oxidation resistant sliding ring polyrotaxane-catechol hydrogels for tissue engineering 6TH TERMIS World Congress
(Glasgow (online), United Kingdom)
2018/10 Síntese E Prospecção Biológica De Híbridos Naftoquinona-Cumarina (English tiltle: "Synthesis and Biological Prospecting of Naphthoquinone-Cumarin Hybrids" XXVIII Seminário de Iniciação Científica e Prêmio UFF Vasconcelos Torres de Ciência e Tecnologia
(Niterói, Brazil)
2017/10 Novos Derivados 1,2,3-Triazólico como Potenciais Moduladores Da Agregação Da Proteína Príon (English Title: "New 1,2,3-Triazol Derivatives as Potential Modulators of Prion Protein Aggregation") XXVII Seminário de Iniciação Científica e Prêmio UFF Vasconcelos Torres de Ciência e Tecnologia
(Niterói, Brazil)
2016/10 Síntese E Avaliação Da Atividade Anti-Príon De Novos Derivados Da Acridina (English Title: "Synthesis and Evaluation of the Anti-Prion Activity of New Acridine Derivatives") XXVI Seminário de Iniciação Científica e Prêmio UFF Vasconcelos Torres de Ciência e Tecnologia
(Niterói, Brazil)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/10/01 - 2022/12/12 Development of injectable hydrogels for application in tissue engineering
Supervisor of Pedro Miguel Ouro
 Chemistry (Master)
Universidade de Aveiro, Portugal
2019/11/15 - 2021/07/25 Research fellow of the Project: "Engineering of marine-inspired high-performance multifunctional hydrogels for cartilage regeneration crosslinked with bioinstructive and sliding non-covalent bonds (MARGEL)"
Co-supervisor of Patrícia Costa
Universidade de Aveiro CICECO, Portugal
2020/11/01 - 2021/01/31 Biomimetic human-based hydrogels through tannin-protein interactions
Supervisor of Diogo Filipe Martins Lopes
 Biotecnologia (Master)
Universidade de Aveiro, Portugal
2017/09/01 - 2019/02/22 Síntese e Prospecção Biológica de Híbridos Naftoquinona-Cumarina (English Title: Synthesis and Biological Prospecting of Naphthoquinone-Coumarin Hybrids)
Co-supervisor of Beatriz Vieira Abunahman Matuck
 Chemistry (Scientific initiation)
Universidade Federal Fluminense Instituto de Química, Brazil
2016/04/01 - 2018/03/31 Novos derivados 1,2,3-triazólico da quinacrina como potenciais moduladores da agregação da proteína prion. (English Title: Novel 1,2,3-triazole derivatives of quinacrine as potential modulators of prion protein aggregation)
Co-supervisor of Juliana Vieira Bernardo
 Chemistry (Scientific initiation)
Universidade Federal Fluminense Instituto de Química, Brazil

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/10/21 - 2019/10/25 3rd Training school under COST action EBNA entitled Bioinspired Adhesive Hydrogels and Polymers. Some pratical experiments were shown to foreign students. (2019/10/21 - 2019/10/21)
Workshop (Co-organisor)
 Universidade de Aveiro CICECO, Portugal
2019/10/10 - 2019/10/12 Techdays (science dissemination activity: simples pratical experiments were shown to general public) (2019/10/10 - 2019/10/12)
Exhibition (Co-organisor)
 Universidade de Aveiro, Portugal
2014 - 2014 Universidade de Verão (science dissemination activity for high school students) (2014 - 2014)
Workshop (Co-organisor)
 Universidade de Coimbra Centro de Química de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/03/10 - 2024/03/15 SUPRALIFE Second School
Congress
 SUPRALIFE Second School
Universidade de Aveiro, Portugal

Technische Universiteit Eindhoven, Netherlands

Université de Bordeaux, France
2023/09/29 - 2023/10/02 SupraLife Scientific Retreat ¿Bonding across Borders"
Congress
 SupraLife Scientific Retreat “Bonding across Borders
Universidade de Aveiro CICECO, Portugal
2023/03/19 - 2023/03/24 SupraLife First School "Functional Supramolecular Polymeric Biomaterials"
Congress
 SupraLife First School "Functional Supramolecular Polymeric Biomaterials"
Universidade de Aveiro, Portugal
2021/02/18 - 2021/02/19 4th International Conference on Biological and Biomimetic Adhesives
Congress
 4th International Conference on Biological and Biomimetic Adhesives
Universidade de Aveiro, Portugal
2020/08/24 - 2020/08/24 LNHC e a química de 4-oxoquinolinas: trajetória e perspectivas (English description: LNHC and the chemistry of 4-oxoquinolines: trajectory and perspectives)
Conference
 I Série De Lives Científicas Do PPGQ Da UERJ
Universidade do Estado do Rio de Janeiro, Brazil
2019/09/11 - 2019/09/15 Web of Science Training in Aveiro
Conference
 Web of Science Training in Aveiro
Universidade de Aveiro, Portugal
2019/06/11 - 2019/06/12 A series of lectures in the field of materials chemistry: "Where Science Meets Society"
Congress
 Jornadas CICECO 2019
Universidade de Aveiro CICECO, Portugal
2018/11/08 - 2018/11/09 VII Annual Meeting of students of the PPGQ – UFF
Meeting
 VII Annual Meeting of students of the PPGQ – UFF
Universidade Federal Fluminense Instituto de Química, Brazil
2018/10/21 - 2018/10/24 17th Brazilian Meeting of Organic Chemistry (17th BMOS)
Congress
 17th Brazilian Meeting of Organic Chemistry (17th BMOS)
Universidade Federal da Bahia, Brazil

Sociedade Brasileira da Química, Brazil
2017/08/16 - 2017/08/16 O processo de Submissão, Editoração e Revisão por pares na divulgação do conhecimento científico
Conference
 A Voz da Pesquisa
Universidade Federal Fluminense, Brazil
2016/03/29 - 2016/04/01 A series of lectures in the field of chemistry
Congress
 XV Encontro Regional da Sociedade Brasileira de Química
Universidade Federal do Rio de Janeiro, Brazil
2014/09/16 - 2014/09/16 The Chemistry Centre Day 2014
Meeting
 The Chemistry Centre Day 2014
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2012/06/13 - 2012/06/13 2nd Research Day, Univeristy of Aveiro
Meeting
 2nd Research Day, Univeristy of Aveiro
Universidade de Aveiro, Portugal
2012/05/09 - 2012/05/11 3rd Portuguese Young Chemists Meeting (PYCHEM 2012)
Congress
 3rd Portuguese Young Chemists Meeting (PYCHEM 2012)
Sociedade Portuguesa da Química, Portugal
2011/07/03 - 2011/07/06 22nd SPQ National Meeting
Congress
 22nd SPQ National Meeting
Sociedade Portuguesa da Química, Portugal
2009/07/01 - 2009/07/03 8th National Meeting on Organic Chemistry
Congress
 8th National Meeting on Organic Chemistry
Sociedade Portuguesa da Química, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/07/07 Chemical Modification Strategies To Prepare Advanced Protein-Based Biomaterials
(Thesis) Main arguer
 Joana Oliveira (Other)
Universidade de Aveiro, Portugal
2022/12/12 Development of injectable hydrogels for application in tissue engineering
Supervisor
 Pedro Ouro (Master)
Universidade de Aveiro, Portugal

Association member

Society Organization name Role
2019/06/01 - Current Sociedade Portuguesa da Química Member
2018/01/01 - 2018/12/31 Sociedade Brasileira da Química Member
2012/01/01 - 2012/12/31 Sociedade Portuguesa da Química Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09/14 - Current Técnicas Transferíveis I: Módulo Técnicas de Comunicação e Apresentações. (English description: "Transferable Techniques: Communication and Presentation Techniques") (Licenciatura) Universidade de Aveiro, Portugal
2021/10/12 - Current Laboratórios de Biomedicina 1 (English description: Biomedicine Laboratory I) Ciências Biomédicas (Licenciatura) Universidade de Aveiro, Portugal
2017/08/17 - 2017/12/22 Estágio em Docência II (English description: Teaching Internship II): Experimental Organic Chemistry V Farmácia (Bachelor (1st cycle)) Universidade Federal Fluminense Instituto de Química, Brazil
2016/08/29 - 2017/01/19 Estágio em Docência I (English description: Teaching Internship I): Theoretical Organic Chemistry XII Engenharia Química (Bachelor (1st cycle)) Universidade Federal Fluminense Instituto de Química, Brazil

Journal scientific committee

Journal title (ISSN) Publisher
2024/01/18 - Current Journal of Functional Biomaterials ( 2079-4983) MDPI
2023/11/15 - Current Arabian Journal of Chemistry (1878-5379) Elsevier
2023/09/21 - Current Biomimetics (2313-7673) MDPI
2023/05/30 - Current Materials (1996-1944) MDPI
2023/03 - Current Gels ( 2310-2861) MDPI
2022/07 - Current Advanced Healthcare Materials (2192-2659) Wiley
2020/07 - Current Materials Today Bio ( 2590-0064) Elsevier
Distinctions

Award

2019 Seal of Excellence in Marie Sklodowska-Curie actions call H2020-MSCA-IF-2019 (Score: 85.6%)
European Commission, Belgium

Other distinction

2022 Top Cited Article 2020- 2021 "para-Quinone Methides as Acceptors in 1,6- Nucleophilic Conjugate Addition Reactions for the Synthesis of Structurally Diverse Molecules" in European Journal of Organic Chemistry
2019 The Best PhD Thesis of PPGQ - UFF
Universidade Federal Fluminense Instituto de Química, Brazil