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Ana Cabral Couto Lopes Nóvoa. Publicou 26 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Animals; Gene Rearrangement; Mice; Snakes; Body Patterning; Gene Expression Regulation, Developmental; Genes, Homeobox; Oct4; Hox genes; vertebrates; gene-expression; genomic; Cell Differentiation; Mice, Transgenic; Microscopy, Confocal; Signal Transduction; Wnt3A Protein; beta Catenin; developmental biology; evolutionary biology; genomics; mouse; reptiles; snakes; squamata; stem cells; Vertebrate patterning; Axial skeleton; Gene regulation; Mouse; Bone Morphogenetic Proteins; Gene Regulatory Networks; Growth Differentiation Factors; Homeodomain Proteins; Mesoderm; RNA-Binding Proteins; Stem Cells; Tail; Animals, Newborn; Base Sequence; Bone and Bones; LIM-Homeodomain Proteins; Molecular Sequence Data; Phenotype; Protein-Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta; Transcription Factors; Tretinoin; embryo; great vessels; neural crest; smooth muscle cells; transcription; Bone Development; Fibroblast Growth Factors; Models, Biological; Models, Genetic; Muscle Development; Myogenic Regulatory Factor 5; Myogenic Regulatory Factors; Platelet-Derived Growth Factor; Band 3; Oxidative stress; Hereditary spherocytosis; .
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Identification

Personal identification

Full name
Ana Cabral Couto Lopes Nóvoa

Citation names

  • Nóvoa, A

Author identifiers

Ciência ID
5410-4C49-FA0D
ORCID iD
0000-0002-5668-5630

Telephones

Telephone
  • 214464525 (Professional)

Addresses

  • Rua da Quinta Grande, 6, 2780-156, Oeiras, Oeiras, Portugal (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
1997/12/11
Concluded
 Bioquímica (Licenciatura)
Major in Bioquímica Aplicada
Universidade do Porto Faculdade de Ciências, Portugal
 13
Affiliation

Science

Category
Host institution 		Employer
2002/01/01 - Current Science and Technology Management Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
Projects

Grant

Designation Funders
2023/02/01 - Current Coordinated development of the legs and external genitalia in vertebrates
2022.01629.PTDC
 Fundação para a Ciência e a Tecnologia
1999/03 - 2001/08 Caracterização molecular da função da MCP1, um autoantigénio humano reconhecido por anticorpos de Lupus Eritematoso Sistémico
PRAXIS/P/SAU/10270/98
Research Technician Fellow
Fundação para a Ciência e a Tecnologia, Portugal

Contract

Designation Funders
2018/07/01 - 2021/06/30 Estudo da mudança de competência celular durante a transição cabeça-tronco
PTDC/BIA-BID/30254/2017
Fundação Calouste Gulbenkian, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05/01 - 2019/07/31 O controlo dos progenitores axiais durante e após a transição tronco-cauda
PTDC/BEX-BID/0899/2014
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 Controlo da expressão de Myf5 e Myf6 por genes Hox
PTDC/BIA-BCM/110638/2009
Fundação Calouste Gulbenkian, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/02/28 Análise da especificidade funcional dos genes Hox no controlo da formação do esqueleto
PTDC/SAU-BID/110640/2009
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/06/01 - 2011/05/31 Alternative spliced isoforms of CD6: on the cross-roads of T cell activation and the regulation of lymphocyte development
PTDC/SAU-MII/64247/2006
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/12/31 Mecanismos moleculares pelos quais os genes Hox controlam a formação do esqueleto axial
PTDC/BIA-BCM/71619/2006
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/03/01 - 2007/03/31 The role on the antisense transcript of Hoxb3 during mouse development
POCI/BIA-BCM/60420/2004
Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Gulbenkian de Ciência, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2003/02/01 - 2006/01 Reversible gene inactivation in the mouse
info:eu-repo/grantAgreement/FCT/POCI/46337/PT
Fundação para a Ciência e a Tecnologia, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded

Other

Designation Funders
2015/01/01 - 2017/12/31 Improving cell substrates for spinal regeneration therapies
SCML-MC-60-2014
Concluded
2008/04/01 - 2010/03/31 Tissue specific evaluation of GNE driven sialic acid production in vivo using cre/lox transgenesis
Grant#024
Concluded
Outputs

Publications

Book chapter
  1. Granjo, Elisa; Santos-Silva, Alice; Rebelo, Irene; Nóvoa, Ana; Costa, Elísio; Barbot, José; Ribeiro, Leticia; Quintanilha, Alexandre. "Hematological and biochemical parameters in hereditary spherocytosis under oxidative stress". Springer, 1999.
Conference paper
  1. Granjo, Elisa; Santos-Silva, Alice; Rebelo, Irene; Nóvoa, Ana; Costa, Elísio; Barbot, José; Ribeiro, Manuela; Quintanilha, Alexandre. "Banda 3 profile as a marker of oxidative stress in hereditary spherocytosis". 1998.
Journal article
  1. Patrícia Duarte; Rion Brattig Correia; Ana Nóvoa; Moises Mallo. "Regulatory changes associated with the head to trunk developmental transition". BMC Biology (2023): http://dx.doi.org/10.1186/s12915-023-01675-2.
    10.1186/s12915-023-01675-2
  2. Sara Petrillo; F. De Giorgio; F. Bertino; F. Garello; V. Bitonto; D. L. Longo; S. Mercurio; et al. "Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis". Angiogenesis (2023): http://dx.doi.org/10.1007/s10456-023-09865-w.
    10.1007/s10456-023-09865-w
  3. Triin Tekko; Anastasiia Lozovska; Ana Nóvoa; Moisés Mallo. "Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos". Developmental Dynamics (2022): https://doi.org/10.1002/dvdy.502.
    10.1002/dvdy.502
  4. Thomas Spruce; Mireya Plass; André Gohr; Debashish Ray; maria martinez de lagran; Gregor Rot; Ana Nóvoa; et al. "The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians". PLOS Biology (2022): http://dx.doi.org/10.1371/journal.pbio.3001615.
    10.1371/journal.pbio.3001615
  5. Luisa de Lemos; André Dias; Ana Nóvoa; Moisés Mallo. "Epha1 is a cell-surface marker for the neuromesodermal competent population". Development 149 6 (2022): https://doi.org/10.1242/dev.198812.
    10.1242/dev.198812
  6. André Dias; Anastasiia Lozovska; Filip J Wymeersch; Ana Nóvoa; Anahi Binagui-Casas; Daniel Sobral; Gabriel G Martins; Valerie Wilson; Moises Mallo. "A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation". eLife (2020): https://doi.org/10.7554/eLife.56615.
    10.7554/eLife.56615
  7. Kyriel M. Pineault; Ana Novoa; Anastasiia Lozovska; Deneen M. Wellik; Moises Mallo. "Two CRISPR/Cas9-mediated methods for targeting complex insertions, deletions, or replacements in mouse". MethodsX 6 (2019): 2088-2100. https://doi.org/10.1016/j.mex.2019.09.003.
    10.1016/j.mex.2019.09.003
  8. Aires, Rita; de Lemos, Luisa; Nóvoa, Ana; Jurberg, Arnon Dias; Mascrez, Bénédicte; Duboule, Denis; Mallo, Moisés. "Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes". (2019): http://hdl.handle.net/10400.7/906.
    10.1016/j.devcel.2018.12.004
  9. Losa, M.; Latorre, V.; Andrabi, M.; Ladam, F.; Sagerström, C.; Novoa, A.; Zarrineh, P.; et al. "A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree". eLife 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032912821&partnerID=MN8TOARS.
    10.7554/eLife.31362
  10. Guerreiro, I.; Gitto, S.; Novoa, A.; Codourey, J.; Nguyen Huynh, T.H.; Gonzalez, F.; Milinkovitch, M.C.; Mallo, M.; Duboule, D.. "Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan". eLife 5 AUGUST (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84982717690&partnerID=MN8TOARS.
    10.7554/eLife.16087
  11. Casaca, A.; Nóvoa, A.; Mallo, M.. "Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity". Development (Cambridge) 143 3 (2016): 437-448. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956622098&partnerID=MN8TOARS.
    10.1242/dev.133074
  12. Aires, R.; Jurberg, A.D.; Leal, F.; Nóvoa, A.; Cohn, M.J.; Mallo, M.. "Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity". Developmental Cell 38 3 (2016): 262-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989932760&partnerID=MN8TOARS.
    10.1016/j.devcel.2016.06.021
  13. Jurberg, A.; Aires, R.; Varela-Lasheras, I.; Nóvoa, A.; Mallo, M.. "Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos". Developmental Cell 25 5 (2013): 451-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878985295&partnerID=MN8TOARS.
    10.1016/j.devcel.2013.05.009
  14. Guerreiro, I.; Nunes, A.; Woltering, J.M.; Casaca, A.; Nóvoa, A.; Vinagre, T.; Hunter, M.E.; Duboule, D.; Mallo, M.. "Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine". Proceedings of the National Academy of Sciences of the United States of America 110 26 (2013): 10682-10686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879511411&partnerID=MN8TOARS.
    10.1073/pnas.1300592110
  15. Jurberg, A.D.; Aires, R.; Nóvoa, A.; Rowland, J.E.; Mallo, M.. "Compartment-dependent activities of Wnt3a/ß-catenin signaling during vertebrate axial extension". Developmental Biology (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84906798547&partnerID=MN8TOARS.
    10.1016/j.ydbio.2014.08.012
  16. Bronze-Da-Rocha, E.; Nóvoa, A.; Teixeira, N.; Vasconcelos, C.S.; Cerveira, C.; Castro E Melo, J.; Carvalho, M.C.. "Evaluation of the reactivity of sera from patient with systemic lupus erythematosus against the human MCP1". Journal of Clinical Immunology 32 4 (2012): 721-728. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863982764&partnerID=MN8TOARS.
    10.1007/s10875-012-9665-4
  17. Guerreiro, I.; Casaca, A.; Nunes, A.; Monteiro, S.; Nóvoa, A.; Ferreira, R.B.; Bom, J.; Mallo, M.. "Regulatory role for a conserved motif adjacent to the homeodomain of Hox10 proteins.". Development (Cambridge, England) 139 15 (2012): 2703-2710. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866788259&partnerID=MN8TOARS.
    10.1242/dev.081448
  18. van de Ven, C.; Bialecka, M.; Neijts, R.; Young, T.; Rowland, J.E.; Stringer, E.J.; van Rooijen, C.; et al. "Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone". Development 138 16 (2011): 3451-3462. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960770539&partnerID=MN8TOARS.
    10.1242/dev.066118
  19. Vinagre, T.; Moncaut, N.; Carapuço, M.; Nóvoa, A.; Bom, J.; Mallo, M.. "Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains". Developmental Cell 18 4 (2010): 655-661. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951925267&partnerID=MN8TOARS.
    10.1016/j.devcel.2010.02.011
  20. Young, T.; Rowland, J.E.; van de Ven, C.; Bialecka, M.; Novoa, A.; Carapuco, M.; van Nes, J.; et al. "Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos". Developmental Cell 17 4 (2009): 516-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349980833&partnerID=MN8TOARS.
    10.1016/j.devcel.2009.08.010
  21. Correia, A.C.; Costa, M.; Moraes, F.; Bom, J.; Nóvoa, A.; Mallo, M.. "Bmp2 is required for migration but not for induction of neural crest cells in the mouse". Developmental Dynamics 236 9 (2007): 2493-2501. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548813113&partnerID=MN8TOARS.
    10.1002/dvdy.21256
  22. Carapuço, M.; Nóvoa, A.; Bobola, N.; Mallo, M.. "Hox genes specify vertebral types in the presomitic mesoderm". Genes and Development 19 18 (2005): 2116-2121. http://www.scopus.com/inward/record.url?eid=2-s2.0-24944555211&partnerID=MN8TOARS.
    10.1101/gad.338705
  23. Moraes, F.; Nóvoa, A.; Jerome-Majewska, L.A.; Papaioannou, V.E.; Mallo, M.. "Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development". Mechanisms of Development 122 2 (2005): 199-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344311144&partnerID=MN8TOARS.
    10.1016/j.mod.2004.10.004

Other

Other output
  1. High Epha1 expression is a potential cell surface marker for embryonic neuro-mesodermal progenitors. 2019. Luisa de Lemos; Ana Nóvoa; Moisés Mallo. https://doi.org/10.1101/584524.
    10.1101/584524
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015/11 - 2015/11 I Congreso Hispano-Luso de Ciencias del Animal de Laboratorio, I Congresso Hispano-Luso de Ciências de Animais de Laboratório, XIII Congreso SECAL, III Congresso SPCAL (2015/11 - 2015/11)
Conference (Member of the Organising Committee)

Conference scientific committee

Conference name Conference host
2012/05 - 2012/05 II SPCAL MEETING SPCAL
Distinctions

Award

2014 Prize Melo e Castro on Spinal Cord Injury Research
Santa Casa da Misericórdia de Lisboa, Portugal
2010 2010 Pfizer Prize of Basic Research
Sociedade das Ciências Médicas de Lisboa (SCMED) e os Laboratórios Pfizer Lda. (Pfizer), Portugal
2005 2005 Pfizer Prize of Basic Research
Sociedade das Ciências Médicas de Lisboa (SCMED) e os Laboratórios Pfizer Lda. (Pfizer), Portugal