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M. Helena Garcia is Associate Professor with Habilitation at University of Lisbon (FCUL) jubilated by 31 of May of 2017. Since then she got a collaboration agreement with FCUL where she continues her leadership on the Organometallic Research Laboratory, working on the synthesis of organometallic compounds for cancer therapy also being co-coordinator of the Bioinorganic Chemistry and Drug Development, Group of the Centro de Química Estrutural (CQE), a Research Unit of the University of Lisbon (ULisboa). M. Helena Garcia is co-founder of the start-up company ´Something in Hands-Investigação Científica, Lda´, of FCUL´s spin-off (rebranded as R-nuucell (http://r-nuucell.com/), a semi finalist of InnoStars - EIT Health awards (2021) and an awardee of Women TechEU (2022). M. Helena Garcia has been leader of several national and European funded scientific research projects and was Member of the Division of Organometallic Chemistry of European Association Chemical and Molecular Sciences, as delegate of Portuguese Chemical Society, in the period 1992-2017. She was for many years the Institutional Erasmus Coordinator at the International Office at Faculty of Sciences of University of Lisbon. M. Helena Garcia has a long experience as a scientific adviser of Post-Doc¿s, PhD, Master, Erasmus and graduation students. She authored over 130 articles published in international journals with peer review and book chapters, 4 inter-/national patents, more than 75 oral presentations (40 by invitation), more than 250 Posters at national and international conferences and several conference proceedings. M. Helena Garcia is co-author of Portuguese translation of the book Nomenclature of Inorganic Chemistry - IUPAC Recommendations 2005 published by the Portuguese Society of Chemistry and IST Press in 2017. M. Helena Garcia was delegate of FCUL at United Nations, Geneva, to participate at “Meeting of Experts “ Geneva, on THE BIOLOGICAL WEAPONS CONVENTION, 16–20 July 2012, Geneva.
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Identification

Personal identification

Full name
Maria Helena Anselmo Viegas Garcia

Citation names

  • Garcia, Maria
  • M. Helena Garcia
  • M. H. Garcia
  • Garcia, M. H.
  • Helena Garcia, M.
  • Garcia, M. Helena
  • Helena Garcia, Maria

Author identifiers

Ciência ID
5414-9AEF-4194
ORCID iD
0000-0002-4344-2218
Researcher Id
H-2175-­2013
Scopus Author Id
6507884466

Email addresses

  • mhgarcia@fc.ul.pt (Professional)

Telephones

Telephone
  • (+351) 217500972 (Professional)

Addresses

  • Faculdade de Ciências Universidade de Lisboa, Campo Grande, Ed. C8, 1749-016, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
1998 - 1998
Concluded
 Química (Título de Agregado)
Universidade de Lisboa Faculdade de Ciências, Portugal
1984
Concluded
 Química (Doutoramento)
Major in Especialidade: Química Inorgânica
Universidade de Lisboa, Portugal
"Química dos Complexos Mcp2 (sr) 2 (m-mo W; R-alquilo Ou Arilo), Seu Uso Como Ligandos" (THESIS/DISSERTATION)
1978
Concluded
 Química Inorgânica Física (Mestrado)
Universidade Nova de Lisboa, Portugal
"Espectros Electrónicos de Complexos Pseudotetraédricos de Co(II) com Ligandos MCp2(SR)2 (M = MoIV ou W; R = Alquilo ou Arilo) " (THESIS/DISSERTATION)
1972
Concluded
 Química (Licenciatura)
Major in Não Aplicável
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2016 - 2017 Associate Professor (University Teacher) Universidade de Lisboa, Portugal
2013 - 2016 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2000 - 2013 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
1998 - 2000 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
1984 - 1998 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
1972 - 1984 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal

Positions / Appointments

Category
Host institution 		Employer
2016 - 2017 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2017 Coordinator of the ERASMUS + Mobility Program at FCUL 2012-2017 (after many years as ERASMUS coordinator of DQB) Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2017 Coordinator of the Degree in Technological Chemistry (several periods) Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2013 Responsible for Master's course in Biomedical Inorganic Chemistry - Applications in Diagnosis and Therapy at DQB-FCUL creation (organized in partnership with the Technological and Nuclear Institute) Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2017/06 - Current Associate Professor with “Habilitation” at FCUL jubilated by 31 May 2017 with a collaboration agreement with FCUL where she continues her leadership on the Organometallic Research Laboratory Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2017/01/22 - Current Founder of HATICancer Proto-Company Universidade de Lisboa Faculdade de Ciências, Portugal
2000/05 - 2000/08 Research Fellow at Arizona University, Tucson, USA Arizona State University, United States
1990/03 - 1990/05 Research Fellow at Organisch-Chemisches Institut, Munique Organisch-Chemisches Institut, Germany
1988/05 - 1988/07 Research Fellow at École Normale Superieure de Paris École Normale Supérieure Paris-Saclay, France
1986/07 - 1986/09 Research Fellow at Oxford University University of Oxford Chemistry Research Laboratory, United Kingdom
1980/05 - 1980/08 Research Fellow at State University of New York College, Oneonta State University of New York College at Oneonta, United States
Projects

Contract

Designation Funders
2015 - Current Complexes of Flavonoid’s Schiff bases: Impact of structural modification on the chelating ability and evaluation of biological and therapeutic properties
FCT RD0480, Project 6818
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2001/01/01 - Current Crystal Engineering: a tool for obtaining new materials
info:eu-repo/grantAgreement/FCT/POCI/35514/PT
Researcher
Universidade do Algarve Faculdade de Ciências e Tecnologia
2001 - Current Síntese e Caracterização de Novos Metalodendrímeros e Determinação das suas Propriedades de Nao-linearidade Óptica
Acção nº 04/11
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2001 - Current Síntese e caracterização de compostos polinucleares com potencial aplicação em óptica não linear (NLO)
POCTI/QUI/35419/2000
Researcher
Fundação para a Ciência e a Tecnologia
2001 - Current Síntese e estudo de novos dendrímeros organometálicos para aplicações opticamente não lineares
POCTI/QUI/41814/2001
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1999 - Current Photorefraction with Organometallic Dipoles in Helical Environments
projecto nº d14/0008/99
Principal investigator
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluded
1999 - Current Organometallic Dipoles with NLO Properties
TMR Network ERB4061PL970101
Principal investigator
Concluded
1996 - Current Síntese de complexos de metais de transição com ligandos ciclopentadienilo e análogos. Aplicações em catálise e novos materiais
PRAXIS XXI nº2/2.1//QUI/143/94
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1995 - Current Bimetallic Cationic Polyene and Poly-yne-Dipoles and Polymetallic Analogues for NLO Effects
projecto B68/5/38
Principal investigator
Concluded
1995 - Current Synthesis of Optically Active Ruthenocene with Chiral Plane and Their Derivatives
Nº 94-1716
Principal investigator
1995 - Current Cyclodextrine-Metallocenes Inclusion Complexes for Non-linear Optics
CRG Nº 941435 CEE
Principal investigator
1994 - Current Síntese de aminoácidos e derivados, catalisada por iões metálicos
2/21/QUI151/94
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1993 - Current New Third Order NLO Molecular Materials
Network nº ERBCHR XCT9330334
Principal investigator
Concluded
1990 - Current Synthesis of nonlinear optical organometallic compounds
PMCT/C/CEN/117/90
Principal investigator
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/09/01 - 2021/08/31 Fighting metastatic cancers: prime time for ruthenium
PTDC/QUI-QIN/28662/2017
Researcher
Universidade do Minho, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/06/01 - 2021/05/31 Development and bio-speciation studies of ruthenium anti-tumor complexes
FCT/NKFIH, 2019/2020
Researcher
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/03/01 - 2015/08/31 “Avaliação pré-clínica de potenciais fármacos de Ruténio na terapia do cancro”
PTDC/QUI-QUI/118077/2010
Principal investigator
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Complexos de Ruténio para aplicação anti-tumoral
PTDC/QUI-QUI/101187/2008
Researcher
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/11/10 - 2012/05/08 Síntese de Materiais Organometálicos Moleculares e Poliméricos com Propriedades de Óptica Não Linear
PTDC/QUI/66148/2006
Principal investigator
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade de Évora, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2011 Concepção de compostos de cobre, zinco ou ferro com actividade leishmanicida
PTDC/QUI/72656/2006
Researcher
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2009 Síntese e estudo de compostos organometálicos/coordenação como comutadores moleculares para as tecnologias da optoelectrónica e fotónica
PTDC/QUI/67362/2006
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1998 - 2002 Novos complexos organometálicos helicoidais com propriedades de nao-linearidade óptica (NLO)
POCTI/QUI/48443/2002
Principal investigator
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1993 - 1997 Síntese de Novos Materiais Moleculares Organometálicos Opticamente Não Lineares
PRAXIS/PCEX/C/QUI/0096/96
Principal investigator
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1988 - 1992 Estudos de Compostos Organometálicos Opticamente Não Lineares
STRDA/P/CEN/512/92
Principal investigator
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Andreia Valente; Tânia S. Morais; Ricardo G. Teixeira; Cristina P. Matos; Ana Isabel Tomaz; M. Helena Garcia. "Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents, Chp 7". In Synthetic Inorganic Chemistry-New Perspectives, edited by Ewan Hamilton. Elsevier, 2021.
    Published
  2. Andreia Valente; Tânia S. Morais; M. Helena Garcia. "Ruténio - o elemento que não para de nos surpreender!". In Os Elementos em Ciências -Uma viagem pela Tabela Periódica (printed version & EPub), edited by Ana Mourato; Ana Paula Carvalho; Filomena Leitão; Teresa Pamplona. Lisbon, Portugal: Faculdade de Ciências da Universidade de Lisboa, 2020.
    In press
  3. A. Matos; F. Mendes; A. Valente; T. S. Morais; A. I. Tomaz; P. Zinck; M. Helena Garcia; M. Bicho; F. Marques. "Ruthenium based anticancer compounds: insights into their cellular targeting and mechanism of action". In Ruthenium Complexes – Photochemical and Biomedical Applications, edited by Alvin A. Holder; Jimmie L. Bullock Jr.; Marc A. Lawrence; Wesley R. Browne; Lothar Lilge. Wiley-VCH book, 2018.
    Published
  4. T. J. L. Silva; P. J. G. Mendes; A. I. Tomaz; M. Helena Garcia. "s-Tetrazines Part 1 - Synthesis of 3,6-bis-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine: an “out-of-the-box” example for heterocyclic chemistry synthesis". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Carlos A M Afonso; Nuno R Candeias; Dulce Pereira Simão; Alexandre F Trindade; Jaime A S Coelho; Bin Tan; Robert Franzén. Royal Society of Chemistry, 2017.
    Published
  5. T. J. L. Silva; P. J. G. Mendes; A. I. Tomaz; M. Helena Garcia. "Synthesis of benzo[c]thiophene". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Carlos A M Afonso; Nuno R Candeias; Dulce Pereira Simão; Alexandre F Trindade; Jaime A S Coelho; Bin Tan; Robert Franzén. Royal Society of Chemistry, 2017.
    Published
  6. T. J. Silva; P. J. Mendes; A. P. S. Teixeira; M. Helena Garcia; M. P. Robalo. "Sonogashira Coupling reaction of aryl derivatives: a versatile method for new acetylide building blocks". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Carlos A M Afonso; Nuno R Candeias; Dulce Pereira Simão; Alexandre F Trindade; Jaime A S Coelho; Bin Tan; Robert Franzén. Royal Society of Chemistry, 2017.
    Published
  7. A. Valente; T. J. L. Silva; P. J. G. Mendes; A. I. Tomaz; M. Helena Garcia. "Polymerization of e-caprolactone using a ruthenium(II) mixed metallocene catalyst". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Carlos A M Afonso; Nuno R Candeias; Dulce Pereira Simão; Alexandre F Trindade; Jaime A S Coelho; Bin Tan; Robert Franzén. Royal Society of Chemistry, 2017.
    Published
  8. T. J. L. Silva; P. J. G. Mendes; A. I. Tomaz; M. Helena Garcia. "Nucleophilic Aromatic Substitution in 3,6-bis-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Carlos A M Afonso; Nuno R Candeias; Dulce Pereira Simão; Alexandre F Trindade; Jaime A S Coelho; Bin Tan; Robert Franzén. Royal Society of Chemistry, 2017.
    Published
  9. T. J. Silva; P. J. Mendes; T. S. Morais; A. Valente; M. P. Robalo; M. Helena Garcia. "“RuCp” a versatile moiety: from NLO to antitumor properties". In Ruthenium: Synthesis, Physicochemical Properties and Applications, edited by Gary P. Keeler. United States: Nova Science Publishers, Inc., 2014.
    Published
  10. M. Helena Garcia; Tânia S. Morais. "On the track to cancer therapy: paving new ways with ruthenium organometallics". In Organometallic Chemistry and Catalysis: Recents advances, the Silver/Gold Jubilee ICOMC Celebratory Book, edited by Armando J. L. Pombeiro. Wiley-VCH book, 2013.
    Published
  11. M. Helena Garcia; Pedro Florindo. "Second Order Nonlinear Optical Properties of Group 8 Half-Sandwich Organometallic Complexes". In Organometallic Compounds: Preparation, Structure and Properties, edited by H.F. Chin, 347-372. Nova York, United States: Nova Science Publishers, 2011.
    Published
  12. E. Goovaerts; W. E. Wenseleers; M. Helena Garcia; G. H. Cross. "Design and characterization of organic and organometallic molecules for second order nonlinear optics". In Handbook of “Advanced Electronic and Photonic Materials and Devices”, edited by H. S. Nalwa, 127-191. 2001.
    Published
  13. A. R. Dias; M. Helena Garcia; P. J. Mendes; M. P. Robalo; J. C. Rodrigues. "Synthesis of organometallic compounds for second-order nonlinear optical properties". In Trends in Organometallic Chemistry, 335-345. Scientific Research Integration, 1994.
    Published
  14. M. J. Calhorda; A. R. Dias; M. Helena Garcia; A. M. Martins; C. C. Romão. "Electrochemistry of New Molybdenocene Dihydrocarbyls". In Paramagnetic Organometallic Species in Activation/Selectivity, Catalysis, edited by M. Chanon; M. Julliard; J. C. Poite, 275-281. NATO ASI Series (Series C: Mathematical and Physical Sciences), Springer, 1989.
    Published • 10.1007/978-94-009-0877-2_19
Conference paper
  1. M. Helena Garcia; A. Valente; T. S. Morais; A. I. Tomaz. "Ruthenium new drug: paving the way for cancer therapy". Paper presented in 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis, 2017.
    Published • 10.1007/s00775-017-1475-y
  2. A. Valente; T. Moreira; A. R. Brás; A. Preto; M. Helena Garcia. "Cancer targeted therapy: the next generation of metallodrugs". Paper presented in 18th International Conference on Biological Inorganic Chemistry, 2017.
    Published • 10.1007/s00775-017-1475-y
  3. Ana Isabel Tomaz; Andreia D. de Sousa; Telma C. Santos; M. Soledade Santos; M. Luísa Corvo; Cristina Matos; M. Helena Garcia; Rodrigo F. M. de Almeida. "On the mechanism of action of new active ruthenium anticancer compounds: a model membrane biophysics approach". Paper presented in ICBIC18 – 18th International Conference on Biological Inorganic Chemistry, Florianópolis, 2017.
    Published • 10.1007/s00775-017-1475-y
  4. M. Helena Garcia; A. Valente; T. S. Morais; F. Marques. "Ruthenium Organometallic compounds as promising antimetastatic drugs for breast cancer chemotherapy". Paper presented in European Chemistry Congress, 2016.
    10.4172/21503494.C1.002
  5. A. Valente; L. Côrte-Real; G. Nogueira; A. Sanches; F. Marques; F. Tortosa; F. Gärtner; N. Mendes; M. Helena Garcia. "Polymer-metal conjugates: Versatile scaffolds for the synthesis of new antitumor drug". 2016.
    10.4172/2150-3494.C1.002
  6. Alves de Matos, Antonio Pedro; Marujo Marques, Fernanda; Corte-Real, Leonor; Helena Garcia, Maria. "Ultrastructural Studies of the Cellular Effects of Antitumoral Compounds.". 2015.
    Published • 10.1017/S1431927615014099
  7. M. Helena Garcia; T. S. Morais; A. I. Tomaz; F. Marques; A. Valente. "Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances". Paper presented in 4th International Conference on Medicinal Chemistry and Computer Aided Drug Designing, Atlanta, 2015.
    Published • 10.4172/21610444.C1.015
  8. A. Valente; M. Helena Garcia; A. Pilon; A. P. Matos; F. Tortosa; N. Mendes; F. Gärtner; et al. "The mode of action of new promising anticancer agents: multifunctional polymerruthenium conjugates". 2015.
    Published • 10.4172/2161-0444.C1.015
  9. M. Helena Garcia; T. S. Morais; A. I. Tomaz; F. Marques; A. Valente. "Ruthenium drugs for cancer therapy: small structural changes, diferente in vivo performances". 2015.
    Published • 10.4172/2161- 0444.C1.015
  10. Garcia, M. Helena; Mendes, Paulo J.; Florindo, Pedro; Silva, Tiago. "Design and synthesis of NLO efficient organometallic molecules". 2015.
    Published • 10.1063/1.4906731
  11. M. Helena Garcia; T. S. Morais; A. Valente; F. Marques. "Tracking antitumor drugs: Ruthenium(II)cyclopentadienyl complexes as promising agents". Paper presented in 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing, , San Francisco, 2014.
    Published • 10.4172/21610444.S1.011
  12. F. Marques; L. Côrte-Real; A. P. Matos; I. Alho; T. S. Morais; A. I. Tomaz; M. Helena Garcia; M. P. Bicho. "Intracellular distribution of antitumor Ru(II) compounds: the lysosome and the lysosomal enzymes as targets for anticancer metal based Drugs". 2013.
    Published • 10.1017/S1431927613000664
  13. Telma C. Santos; Cristina P. Matos; Filipa C. Santos; Luísa C. Corvo; M. Helena Garcia; Ana Isabel Tomaz; Rodrigo F. M. de Almeida. "Interaction of new active Ruthenium anticancer agents with lipid bilayers". Paper presented in 9th European-Biophysical-Societies-Association Congress, Lisboa, 2013.
    Published • 10.1007/s00249-013-0917-x
  14. T. S. Morais; M. Helena Garcia; M. P. Robalo; A. Valente; V. Moreno; M. Font-Bardia; T. Calvet; J. Lorenzo; F. X. Avilés. "Cytotoxicity Studies and DNA Interaction of New Ruthenium(II) Cyclopentadienyl Complexes with Nitrogen Coordinated Ligands". Paper presented in XII Iberian Meeting of Electrochemistry and XVI Meeting of the Portuguese Electrochemical Society, 2010.
  15. T. J.L. Silva; P. J.G. Mendes; M. Helena Garcia; M. P. Robalo. "Ruthenium(II) and Iron(II) Complexes BearingLow Band-gap Thiophenic Ligands as Possible NLO Switches". Paper presented in XII Iberian Meeting of Electrochemistry and XVI Meeting of the Portuguese Electrochemical Society, Lisboa, 2010.
    Published
  16. M. N. Chhaganlal; M. Helena Garcia; M. P. Robalo; V. Moreno. "Ion(II) and Ruthenium(II) Cyclopentadienyl Derivative Complexes: New Potential Antitumor Agents". Paper presented in XII Iberian Meeting of Electrochemistry and XVI Meeting of the Portuguese Electrochemical Society, Lisboa, 2010.
    Published
  17. A. M. Santos; P. J. Mendes; T. J. L. Silva; M. Helena Garcia; M. P. Robalo. "Complexes for NLO: Cyclic Voltammetry Study". Paper presented in XII Iberian Meeting of Electrochemistry and XVI Meeting of the Portuguese Electrochemical Society, Lisboa, 2010.
    Published
  18. J. Rodrigues; Z. Csok; W. Czardybon; J. Figueira; M. Jardim; J. Mesquita; M. Helena Garcia; et al. "Organometallic Materials for Photonics and Molecular Electronics Nanoscale Devices". 2006.
    Published
  19. L. Straver; V. Petricek; M. T. Duarte; M. F. M. da Piedade; M. P. Robalo; A. P. S. Teixeira; M. Helena Garcia. "Modulated Structure of [FeCl(DMPE)2(NCC6H4NO2)][PF6] a Material for Use in NLO". 2005.
    Published • 10.1107/S0108767305080165
  20. M. T. Duarte; M. F. M. Piedade; C. Jacob; M. P. Robalo; M. Helena Garcia. "From Carboxylic Precursors to Thioxanthones: Interplay of Hydrogen Bonds, Br…nitro, S…carbonyl and pi…pi stacking interactions". Paper presented in Acta Cryst., 2005.
    Published • 10.1107/S0108767305085508
  21. M. F. M. Piedade; A. R. Dias; M. T. Duarte; P. Florindo; M. Helena Garcia. "Molecular Structure and Crystal Packing of CpMR Isonitriles (M = Ru, Fe; R = Phosphines and TMEDA). How to Obtain New Solids for NLO". Budapeste, 2004.
  22. M. F. M. da Piedade; A.R. Dias; M. T. Duarte; P. Florindo; M. Helena Garcia. "Molecular Structure and Crystal Packing of CpMR Isonitriles (M = Ru, Fe; R = Phosphines and TMEDA). How to Obtain New Solids for NLO". 2004.
    Published • 10.1107/S0108767304094000
Conference poster
  1. M. Helena Garcia. "More than 250 Panel Communications (“Poster”) at international and national scientific meetings". 2020.
Journal article
  1. Teixeira, Ricardo G.; Mészáros, János P.; Matos, Beatriz; Côrte-Real, Leonor; Xavier, Cristina P.R.; Fontrodona, Xavier; Garcia, M. Helena; et al. Corresponding author: Valente, Andreia. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry 262 (2023): 115922. http://dx.doi.org/10.1016/j.ejmech.2023.115922.
    10.1016/j.ejmech.2023.115922
  2. Pilon, Adhan; Avecilla, Fernando; Rácz, Bálint; Gátszegi, Gerda T.; Spengler, Gabriella; Robalo, M. Paula; Enyedy, Éva A.; Garcia, M. Helena; Valente, Andreia. "Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane". Journal of Inorganic Biochemistry 249 (2023): 112386. http://dx.doi.org/10.1016/j.jinorgbio.2023.112386.
    10.1016/j.jinorgbio.2023.112386
  3. Pilon, Adhan; Avecilla, Fernando; Mohai, Miklós; Enyedy, Éva A.; Rácz, Bálint; Spengler, Gabriella; Garcia, M. Helena; Valente, Andreia. "First iron(II) organometallic compound acting as ABCB1 inhibitor". European Journal of Medicinal Chemistry 256 (2023): 115466. http://dx.doi.org/10.1016/j.ejmech.2023.115466.
    10.1016/j.ejmech.2023.115466
  4. Morais, Tânia S.; Marques, Fernanda; Madeira, Paulo J. Amorim; Robalo, Maria Paula; Garcia, Maria Helena. Corresponding author: Garcia, Maria Helena. "Design and Anticancer Properties of New Water-Soluble Ruthenium–Cyclopentadienyl Complexes". Pharmaceuticals 15 7 (2022): 862. http://dx.doi.org/10.3390/ph15070862.
    10.3390/ph15070862
  5. Côrte-Real, Leonor; Brás, Ana Rita; Pilon, Adhan; Mendes, Nuno; Ribeiro, Ana Sofia; Martins, Tiago D.; Farinha, José Paulo S.; et al. Corresponding author: Valente, Andreia. "Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model". Pharmaceutics 14 7 (2022): 1388. http://dx.doi.org/10.3390/pharmaceutics14071388.
    10.3390/pharmaceutics14071388
  6. Santos, Filipa C.; Costa, Paulo J.; Helena Garcia, Maria; Morais, Tânia S.. "Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods". BioMetals 34 5 (2021): 1029-1042. http://dx.doi.org/10.1007/s10534-021-00325-w.
    Published • 10.1007/s10534-021-00325-w
  7. Sequeira, Diogo; Baptista, Pedro V.; Valente, Ruben; Piedade, M. Fátima M.; Garcia, M. Helena; Morais, Tânia S.; Fernandes, Alexandra R.. "Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action". Dalton Transactions 50 5 (2021): 1845-1865. http://dx.doi.org/10.1039/d0dt03566a.
    Published • 10.1039/d0dt03566a
  8. Teixeira, Ricardo G.; Belisario, Dimas C.; Fontrodona, Xavier; Romero, Isabel; Tomaz, Ana Isabel; Garcia, M. Helena; Riganti, Chiara; Valente, Andreia. "Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds". Inorganic Chemistry Frontiers (2021): http://dx.doi.org/10.1039/d0qi01344g.
    Published • 10.1039/d0qi01344g
  9. Pilon, Adhan; Brás, Ana Rita; Côrte-Real, Leonor; Avecilla, Fernando; Costa, Paulo J.; Preto, Ana; Garcia, M. Helena; Valente, Andreia. "A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells". Molecules 25 7 (2020): 1592. http://dx.doi.org/10.3390/molecules25071592.
    Published • 10.3390/molecules25071592
  10. Teixeira, Ricardo G.; Marques, Fernanda; Robalo, M. Paula; Fontrodona, Xavier; Garcia, M. Helena; Geninatti Crich, Simonetta; Viñas, Clara; Valente, Andreia. "Ruthenium carboranyl complexes with 2,2'-bipyridine derivatives for potential bimodal therapy application". RSC Advances 10 28 (2020): 16266-16276. http://dx.doi.org/10.1039/d0ra01522a.
    Published • 10.1039/d0ra01522a
  11. Franco Machado, João; Machuqueiro, Miguel; Marques, Fernanda; Robalo, M. Paula; Piedade, M. Fátima M.; Garcia, M. Helena; Correia, João D. G.; Morais, Tânia S.. "Novel “ruthenium cyclopentadienyl”–peptide conjugate complexes against human FGFR(+) breast cancer". Dalton Transactions 49 18 (2020): 5974-5987. http://dx.doi.org/10.1039/d0dt00955e.
    Published • 10.1039/d0dt00955e
  12. Machado, João Franco; Sequeira, Diogo; Marques, Fernanda; Piedade, M. Fátima M.; Villa de Brito, Maria J.; Helena Garcia, M.; Fernandes, Alexandra R.; Morais, Tânia S.. "New copper(i) complexes selective for prostate cancer cells". Dalton Transactions 49 35 (2020): 12273-12286. http://dx.doi.org/10.1039/d0dt02157a.
    Published • 10.1039/d0dt02157a
  13. Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Bagci-Onder, Tugba; Cevik, Ozge; Nunes, Patrique; et al. "Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties". Data in Brief 27 (2019): 104548. http://dx.doi.org/10.1016/j.dib.2019.104548.
    Published • 10.1016/j.dib.2019.104548
  14. Gano, Lurdes; Pinheiro, Teresa; Matos, António P.; Tortosa, Francisco; Jorge, Tiago F.; Gonçalves, Maria S.; Martins, Marta; et al. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry 19 10 (2019): 1262-1275. http://dx.doi.org/10.2174/1871520619666190318152726.
    Published • 10.2174/1871520619666190318152726
  15. Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Onder, Tugba Bagci; Cevik, Ozge; Nunes, Patrique; et al. "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?". European Journal of Medicinal Chemistry 176 (2019): 492-512. http://dx.doi.org/10.1016/j.ejmech.2019.04.070.
    Published • 10.1016/j.ejmech.2019.04.070
  16. Côrte-Real, Leonor; Karas, Brittany; Brás, Ana Rita; Pilon, Adhan; Avecilla, Fernando; Marques, Fernanda; Preto, Ana; et al. "Ruthenium–Cyclopentadienyl Bipyridine–Biotin Based Compounds: Synthesis and Biological Effect". Inorganic Chemistry 58 14 (2019): 9135-9149. http://dx.doi.org/10.1021/acs.inorgchem.9b00735.
    Published • 10.1021/acs.inorgchem.9b00735
  17. Moreira, Tiago; Francisco, Rita; Comsa, Elisabeta; Duban-Deweer, Sophie; Labas, Valérie; Teixeira-Gomes, Ana-Paula; Combes-Soia, Lucie; et al. "Polymer “ruthenium-cyclopentadienyl” conjugates - New emerging anti-cancer drugs". European Journal of Medicinal Chemistry 168 (2019): 373-384. http://dx.doi.org/10.1016/j.ejmech.2019.02.061.
    Published • 10.1016/j.ejmech.2019.02.061
  18. Côrte-Real, Leonor; Karas, Brittany; Gírio, Patrícia; Moreno, Alexis; Avecilla, Fernando; Marques, Fernanda; Buckley, Brian T.; et al. "Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand". European Journal of Medicinal Chemistry 163 (2019): 853-863. http://dx.doi.org/10.1016/j.ejmech.2018.12.022.
    Published • 10.1016/j.ejmech.2018.12.022
  19. Bravo, Catarina; Robalo, M. Paula; Marques, Fernanda; Fernandes, Alexandra R.; Sequeira, Diogo A.; M. Piedade, M. Fátima; Garcia, M. Helena; de Brito, Maria J. Villa; Morais, Tânia S.. "First heterobimetallic Cu(i)–dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity". New Journal of Chemistry 43 31 (2019): 12308-12317. http://dx.doi.org/10.1039/c9nj02068c.
    Published • 10.1039/c9nj02068c
  20. Côrte-Real, Leonor; Teixeira, Ricardo G.; Gírio, Patrícia; Comsa, Elisabeta; Moreno, Alexis; Nasr, Rachad; Baubichon-Cortay, Hélène; et al. "Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential". Inorganic Chemistry 57 8 (2018): 4629-4639. http://dx.doi.org/10.1021/acs.inorgchem.8b00358.
    Published • 10.1021/acs.inorgchem.8b00358
  21. Teixeira, Ricardo G.; Brás, Ana Rita; Côrte-Real, Leonor; Tatikonda, Rajendhraprasad; Sanches, Anabela; Robalo, M. Paula; Avecilla, Fernando; et al. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells". European Journal of Medicinal Chemistry 143 (2018): 503-514. http://dx.doi.org/10.1016/j.ejmech.2017.11.059.
    Published • 10.1016/j.ejmech.2017.11.059
  22. Morais, Tânia S.; Jousseaume, Yann; M. Piedade, M. Fátima; Roma-Rodrigues, Catarina; Fernandes, Alexandra R.; Marques, Fernanda; Villa de Brito, Maria J.; Garcia, M. Helena. "Important cytotoxic and cytostatic effects of new copper(i)–phosphane compounds with N,N, N,O and N,S bidentate ligands". Dalton Transactions 47 23 (2018): 7819-7829. http://dx.doi.org/10.1039/c8dt01653d.
    Published • 10.1039/c8dt01653d
  23. Pilon, Adhan; Gírio, Patrícia; Nogueira, Guilherme; Avecilla, Fernando; Adams, Harry; Lorenzo, Julia; Garcia, M. Helena; Valente, Andreia. "New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity". Journal of Organometallic Chemistry 852 (2017): 34-42. http://dx.doi.org/10.1016/j.jorganchem.2017.10.004.
    Published • 10.1016/j.jorganchem.2017.10.004
  24. Lopes, João; Alves, David; Morais, Tânia S.; Costa, Paulo J.; Piedade, M. Fátima M.; Marques, Fernanda; Villa de Brito, Maria J.; Helena Garcia, M.. "New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity". Journal of Inorganic Biochemistry 169 (2017): 68-78. http://dx.doi.org/10.1016/j.jinorgbio.2017.01.007.
    Published • 10.1016/j.jinorgbio.2017.01.007
  25. Dömötör, Orsolya; de Almeida, Rodrigo F.M.; Côrte-Real, Leonor; Matos, Cristina P.; Marques, Fernanda; Matos, António; Real, Carla; et al. "Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes". Journal of Inorganic Biochemistry 168 (2017): 27-37. http://dx.doi.org/10.1016/j.jinorgbio.2016.12.008.
    Published • 10.1016/j.jinorgbio.2016.12.008
  26. Dömötör, Orsolya; de Almeida, Rodrigo F.M.; Côrte-Real, Leonor; Matos, Cristina P.; Marques, Fernanda; Matos, António; Real, Carla; et al. "Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes". Journal of Inorganic Biochemistry 168 (2017): 27-37. http://dx.doi.org/10.1016/j.jinorgbio.2016.12.008.
    Published • 10.1016/j.jinorgbio.2016.12.008
  27. Mendes, Nuno; Tortosa, Francisco; Valente, Andreia; Marques, Fernanda; Matos, António; Morais, Tânia S.; Tomaz, Ana; Gärtner, Fátima; Garcia, M. Helena. "In vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic 1 Triple Negative Breast Cancer Model". Anti-Cancer Agents in Medicinal Chemistry 16 999 (2016): 1-1. http://dx.doi.org/10.2174/1871520616666160922165133.
    Published • 10.2174/1871520616666160922165133
  28. Nogueira, Guilherme; Domotor, Orsolya; Pilon, Adhan; Paula Robalo, M.; Avecilla, Fernando; Helena Garcia, M.; Enyedy, Eva A.; Valente, Andreia. "eta(6)-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2 '-bipyridine and its derivatives: Solution speciation and kinetic behaviour". Journal of Organometallic Chemistry 820 820 (2016): 20-29. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382200300004&KeyUID=WOS:000382200300004.
    Published • 10.1016/j.jorganchem.2016.07.017
  29. Tânia S. Morais; Andreia Valente; Ana Isabel Tomaz; Fernanda Marques; Maria Helena Garcia. "Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds". Future Medicinal Chemistry 8 5 (2016): 527-544. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000374768900004&KeyUID=WOS:000374768900004.
    Published • 10.4155/fmc.16.7
  30. Fernandez, Mariana; Arce, Esteban Rodriguez; Sarniguet, Cynthia; Morais, Tânia S.; Tomaz, Ana Isabel; Azar, Claudio Olea; Figueroa, Roberto; et al. "Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites". Journal of Inorganic Biochemistry 153 153 (2015): 306-314. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000367563200035&KeyUID=WOS:000367563200035.
    Published • 10.1016/j.jinorgbio.2015.06.018
  31. Corte-Real, Leonor; Paula Robalo, M.; Marques, Fernanda; Nogueira, Guilherme; Avecilla, Fernando; Silva, Tiago J. L.; Santos, Filipa C.; et al. "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds". Journal of Inorganic Biochemistry 150 150 (2015): 148-159. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366344800017&KeyUID=WOS:000366344800017.
    Published • 10.1016/j.jinorgbio.2015.06.015
  32. Rodriguez Arce, Esteban; Sarniguet, Cynthia; Morais, Tânia S.; Vieites, Marisol; Isabel Tomaz, A.; Medeiros, Andrea; Comini, Marcelo A.; et al. "A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites". Journal of Coordination Chemistry 68 16 (2015): 2923-2937. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359822900014&KeyUID=WOS:000359822900014.
    Published • 10.1080/00958972.2015.1062480
  33. Valente, Andreia; Santos, Ana Margarida; Côrte-Real, Leonor; Robalo, M. Paula; Moreno, Virtudes; Font-Bardia, Mercè; Calvet, Teresa; Lorenzo, Julia; Garcia, M. Helena. "New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells". Journal of Organometallic Chemistry 756 (2014): 52-60. http://dx.doi.org/10.1016/j.jorganchem.2014.01.027.
    Published • 10.1016/j.jorganchem.2014.01.027
  34. Valente, Andreia; Garcia, M. H.. "Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs". Inorganics 2 1 (2014): 96-114. http://dx.doi.org/10.3390/inorganics2010096.
    Published • 10.3390/inorganics2010096
  35. Silva, Tiago J. L.; Mendes, Paulo J.; Santos, Ana M.; Garcia, M. Helena; Robalo, M. Paula; Ramalho, J. P. Prates; Carvalho, A. J. Palace; et al. "Mono(¿5-cyclopentadienyl)metal(II) Complexes with Thienyl Acetylide Chromophores: Synthesis, Electrochemical Studies, and First Hyperpolarizabilities". Organometallics 33 18 (2014): 4655-4671. http://dx.doi.org/10.1021/om4001204.
    Published • 10.1021/om4001204
  36. Morais, T. S.; Santos, F.C.; Jorge, T.F.; Côrte-Real, L.; Madeira, P.J.A.; Marques, F.; Robalo, M.P.; et al. "New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution". Journal of Inorganic Biochemistry 130 1 (2014): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885498325&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.09.013
  37. Corte-Real, L.; Mendes, F.; Coimbra, J.; Morais, T. S.; Tomaz, A. I.; Valente, A.; Garcia, M. H.; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867.
    Published • 10.1007/s00775-014-1120-y
  38. Gonçalves, G.; Tomaz, I.; Correia, I.; Veiros, L.F.; Castro, M.M.C.A.; Avecilla, F.; Palacio, L.; et al. "A novel VIVO-pyrimidinone complex: Synthesis, solution speciation and human serum protein binding". Dalton Transactions 42 33 (2013): 11841-11861. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881157675&partnerID=MN8TOARS.
    Published • 10.1039/c3dt50553g
  39. Quintal, S.; Morais, T. S.; Matos, C.P.; Paula Robalo, M.; Piedade, M.F.M.; Villa De Brito, M.J.; Helena Garcia, M.; et al. "Synthesis, structural characterization and leishmanicidal activity evaluation of ferrocenyl N-heterocyclic compounds". Journal of Organometallic Chemistry 745-746 (2013): 299-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883307751&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2013.07.044
  40. Matos, C.P.; Valente, A.; Marques, F.; Adão, P.; Paula Robalo, M.; De Almeida, R.F.M.; Pessoa, J.C.; et al. "New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins". Inorganica Chimica Acta 394 (2013): 616-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868218698&partnerID=MN8TOARS.
    Published • 10.1016/j.ica.2012.09.026
  41. Côrte-Real, L.; Matos, A.P.; Alho, I.; Morais, T. S.; Tomaz, A.I.; Garcia, M. H.; Santos, I.; Bicho, M.P.; Marques, F.. "Cellular uptake mechanisms of an antitumor ruthenium compound: The endosomal/lysosomal system as a target for anticancer metal-based drugs". Microscopy and Microanalysis 19 5 (2013): 1122-1130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884579362&partnerID=MN8TOARS.
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  42. Morais, T. S.; Santos, F.C.; Corte-Real, L.; Garcia, M. H.. "Exploring the effect of the ligand design on the interactions between [Ru(¿5-C5H5)(PPh3)(N,O)][CF 3SO3] complexes and human serum albumin". Journal of Inorganic Biochemistry 129 (2013): 94-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884952269&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.09.008
  43. Gonçalves, A.C.; Morais, T. S.; Robalo, M.P.; Marques, F.; Avecilla, F.; Matos, C.P.; Santos, I.; Tomaz, A.I.; Garcia, M. H.. "Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands". Journal of Inorganic Biochemistry 129 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882795489&partnerID=MN8TOARS.
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  44. Valente, A.; Garcia, M. H.; Marques, F.; Miao, Y.; Rousseau, C.; Zinck, P.. "First polymer "ruthenium-cyclopentadienyl" complex as potential anticancer agent". Journal of Inorganic Biochemistry 127 (2013): 79-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884576725&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.07.002
  45. Valente, A.; Royer, S.; Narendra, M.; Silva, T.J.L.; Mendes, P.J.G.; Robalo, M.P.; Abreu, M.; Heck, J.; Garcia, M. H.. "Synthesis of new Fe(II) and Ru(II) ¿5-monocyclopentadienyl compounds showing significant second order NLO properties". Journal of Organometallic Chemistry 736 (2013): 42-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876167870&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2013.02.028
  46. Morais, T. S.; Santos, F.; Côrte-Real, L.; Marques, F.; Robalo, M.P.; Madeira, P.J.A.; Garcia, M. H.. "Biological activity and cellular uptake of [Ru(¿5-C 5H5)(PPh3)(Me2bpy)][CF 3SO3] complex". Journal of Inorganic Biochemistry 122 (2013): 8-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873704110&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.01.011
  47. Silva, Tiago J. L.; Mendes, Paulo J.; Helena Garcia, M.; Paula Robalo, M.; Prates Ramalho, J. P.; Palace Carvalho, A. J.; Buechert, Marina; Wittenburg, Christian; Heck, Juergen. "Benzo[c]thiophene Chromophores Linked to Cationic Fe and Ru Derivatives for NLO Materials: Synthesis Characterization and Quadratic Hyperpolarizabilities". European Journal of Inorganic Chemistry 2013 20 (2013): 3506-3517.
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  48. Morais, T. S.; Garcia, M. H.; Robalo, M.P.; Piedade, M.F.M.; Duarte, M.T.; Villa De Brito, M.J.; Amorim Madeira, P.J.. "Synthesis and structural characterization of new piano-stool ruthenium(II) complexes bearing 1-butylimidazole heteroaromatic ligand". Journal of Organometallic Chemistry 713 (2012): 112-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862600442&partnerID=MN8TOARS.
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  49. Mendes, P.J.; Silva, T.J.L.; Garcia, M. H.; Ramalho, J.P.P.; Carvalho, A.J.P.. "Switchable nonlinear optical properties of ¿ 5- monocyclopentadienylmetal complexes: A DFT approach". Journal of Chemical Information and Modeling 52 8 (2012): 1970-1983. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865448971&partnerID=MN8TOARS.
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  50. Madeira, P.J.A.; Morais, T. S.; Silva, T.J.L.; Florindo, P.; Garcia, M. H.. "Gas-phase behaviour of Ru(II) cyclopentadienyl-derived complexes with N-coordinated ligands by electrospray ionization mass spectrometry: Fragmentation pathways and energetics". Rapid Communications in Mass Spectrometry 26 15 (2012): 1675-1686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862733700&partnerID=MN8TOARS.
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  51. Domingos, S. R.; Silva, P. S. P.; Buma, W. J.; Garcia, M. H.; Lopes, N. C.; Paixao, J. A.; Silva, M. R.; Woutersen, S.. "Amplification of the linear and nonlinear optical response of a chiral molecular crystal". Journal of Chemical Physics 136 13 (2012): 9-9.
    10.1063/1.3697842
  52. Tomaz, Ana Isabel; Jakusch, Tamas; Morais, Tânia S.; Marques, Fernanda; de Almeida, Rodrigo F. M.; Mendes, Filipa; Enyedy, Eva A.; et al. "Ru-II(eta(5)-C5H5)(bipy)(PPh3) (+), a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin". Journal of Inorganic Biochemistry 117 (2012): 261-269.
    Published • 10.1016/j.jinorgbio.2012.06.016
  53. Morais, Tânia S.; Silva, Tiago J. L.; Marques, Fernanda; Paula Robalo, M.; Avecilla, Fernando; Amorim Madeira, Paulo J.; Mendes, Paulo J. G.; Santos, Isabel; Helena Garcia, M.. "Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines". Journal of Inorganic Biochemistry 114 (2012): 65-74.
    Published • 10.1016/j.jinorgbio.2012.04.014
  54. Valente, A.; Zinck, P.; Mortreux, A.; Visseaux, M.; Mendes, P.J.G.; Silva, T.J.L.; Garcia, M. H.. "Polymerization of e-caprolactone using ruthenium(II) mixed metallocene catalysts and isopropyl alcohol: Living character and mechanistic study". Journal of Molecular Catalysis A: Chemical 346 1-2 (2011): 102-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051591704&partnerID=MN8TOARS.
    Published • 10.1016/j.molcata.2011.06.015
  55. Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Aviles, F. X.; Garcia, M.H.; Morais, T. S.; Valente, A.; Robalo, M. P.. "DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands". Journal of Inorganic Biochemistry 105 2 (2011): 241-249.
    Published • 10.1016/j.jinorgbio.2010.10.009
  56. Moreno, V.; Lorenzo, J.; Aviles, F.X.; Garcia, M. H.; Ribeiro, J.P.; Morais, T. S.; Florindo, P.; Robalo, M.P.. "Studies of the antiproliferative activity of ruthenium (II) Cyclopentadienyl-derived complexes with nitrogen coordinated ligands". Bioinorganic Chemistry and Applications 2010 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954567506&partnerID=MN8TOARS.
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  57. Garcia, M. H.; Valente, A.; Florindo, P.; Morais, T. S.; Piedade, M.F.M.; Duarte, M.T.; Moreno, V.; Avilés, F.X.; Loreno, J.. "New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy". Inorganica Chimica Acta 363 14 (2010): 3765-3775. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957982339&partnerID=MN8TOARS.
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  58. Silva, P. S. P.; Cardoso, C.; Silva, M. R.; Paixao, J. A.; Beja, A. M.; Garcia, M. H.; Lopes, N.. "Crystal Structure and Experimental and Theoretical Studies of the Second-Order Nonlinear Optical Properties of Salts of Triphenylguanidine with Carboxylic Acids". Journal of Physical Chemistry A 114 7 (2010): 2607-2617.
    Published • 10.1021/jp909005q
  59. Garcia, M. H.; Florindo, P.; Piedade, M.F.M.; Duarte, M.T.; Robalo, M.P.; Goovaerts, E.; Wenseleers, W.. "Synthesis and structural characterization of ruthenium(II) and iron(II) complexes containing 1,2-di-(2-thienyl)-ethene derived ligands as chromophores". Journal of Organometallic Chemistry 694 3 (2009): 433-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149481277&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2008.11.019
  60. Garcia, M. H.; Mendes, P.J.; Robalo, M.P.; Duarte, M.T.; Lopes, N.. "Synthesis and electrochemical studies of ¿5-monocyclopentadienylruthenium(II) complexes with substituted thiophene nitrile ligands. Crystal structure of [Ru(¿5-C5H5)(dppe)(NC{SC4H2}2NO2)][PF6]". Journal of Organometallic Chemistry 694 18 (2009): 2888-2897. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650601613&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2009.04.025
  61. Garcia, M. H.; Florindo, P.; Piedade, M.F.M.; Duarte, M.T.. "Synthesis and structural characterization of silver(I) complexes with moon-shaped benzo[1,2-b;4,3-b']dithiophene phosphine derivative ligands". Polyhedron 28 2 (2009): 239-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149328390&partnerID=MN8TOARS.
    Published • 10.1016/j.poly.2008.11.013
  62. Garcia, M. H.; Florindo, P.; Piedade, M.d.F.M.; Maiorana, S.; Licandro, E.. "New organometallic Ru(II) and Fe(II) complexes with tetrathia-[7]-helicene derivative ligands". Polyhedron 28 3 (2009): 621-629. http://www.scopus.com/inward/record.url?eid=2-s2.0-59349104787&partnerID=MN8TOARS.
    Published • 10.1016/j.poly.2008.12.036
  63. Garcia, M. H.; Morais, T. S.; Florindo, P.; Piedade, M. F. M.; Moreno, V.; Ciudad, C.; Noe, V.. "Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands". Journal of Inorganic Biochemistry 103 3 (2009): 354-361.
    Published • 10.1016/j.jinorgbio.2008.11.016
  64. Garcia, M. H.; Florindo, P.; Piedade, M.F.M.; Duarte, M.T.; Robalo, M.P.; Heck, J.; Wittenburg, C.; Holtmann, J.; Licandro, E.. "Synthesis of organometallic Ru(II) and Fe(II) complexes containing fused rings hemi-helical ligands as chromophores. Evaluation of non-linear optical properties by HRS". Journal of Organometallic Chemistry 693 18 (2008): 2987-2999. http://www.scopus.com/inward/record.url?eid=2-s2.0-48949086328&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2008.05.035
  65. Garcia, M. H.; Mendes, P.J.; Robalo, M.P.; Dias, A.R.; Campo, J.; Wenseleers, W.; Goovaerts, E.. "Compromise between conjugation length and charge-transfer in nonlinear optical ¿5-monocyclopentadienyliron(II) complexes with substituted oligo-thiophene nitrile ligands: Synthesis, electrochemical studies and first hyperpolarizabilities". Journal of Organometallic Chemistry 692 14 (2007): 3027-3041. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249669781&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2007.03.023
  66. Duarte, M.T.; Fátima, M.; Piedade, M.; Robalo, M.P.; Jacob, C.; Garcia, M. H.. "The effect of counter-ions on the supramolecular arrangement of (benzonitrile)[1,2-bis(diphenylphosphino)ethane](¿5- cyclopentadienyl)iron(II) cations". Acta Crystallographica Section C: Crystal Structure Communications 62 11 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33750924801&partnerID=MN8TOARS.
    Published • 10.1107/S0108270106038662
  67. Malessa, M.; Heck, J.; Kopf, J.; Garcia, M. H.. "Polar cofacially fixed sandwich complexes: Do they demonstrate second harmonic generation (SHG)?". European Journal of Inorganic Chemistry 4 (2006): 857-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644612864&partnerID=MN8TOARS.
    Published • 10.1002/ejic.200500812
  68. Robalo, M. P.; Teixeira, A. P. S.; Garcia, M. H.; da Piedade, M. F. M.; Duarte, M. T.; Dias, A. R.; Campo, J.; Wenseleers, W.; Goovaerts, E.. "Synthesis, characterisation and molecular hyperpolarisabilities of pseudo-octahedral hydrido(nitrile)iron(II) complexes for nonlinear optics: X-ray structure of Fe(H)(dppe)(2)(4-NCC6H4NO2) PF6 .CH2Cl2". European Journal of Inorganic Chemistry 11 (2006): 2175-2185.
    Published • 10.1002/ejic.200501050
  69. Ornelas, C.; Gandum, C.; Mesquita, J.; Rodrigues, J.; Garcia, M. H.; Lopes, N.; Robalo, M.P.; Nättinen, K.; Rissanen, K.. "Synthesis, characterization and crystal structure of the bimetallic cyano-bridged [(¿5-C5H5)(PPh 3)2Ru(µ-CN)Ru(PPh3)2(¿ 5-C5H5)][PF6]". Inorganica Chimica Acta 358 8 (2005): 2482-2488. http://www.scopus.com/inward/record.url?eid=2-s2.0-16844369729&partnerID=MN8TOARS.
    Published • 10.1016/j.ica.2005.02.002
  70. Duarte, M.T.; Piedade, M.F.M.; Robalo, M.P.; Teixeira, A.P.S.; Garcia, M. H.. "A supramolecular zigzag chain of organometallic dipoles mediated by PF 6 - anions". Acta Crystallographica Section C: Crystal Structure Communications 61 8 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-30744478976&partnerID=MN8TOARS.
    Published • 10.1107/S0108270105021281
  71. Garcia, M. H.; Mendes, P.J.; Dias, A.R.. "Synthesis and electrochemical studies of organometallic cobalt(III) complexes with substituted benzonitrile chromophores: NMR spectroscopic data as a probe on the second-order non-linear optical properties". Journal of Organometallic Chemistry 690 17 (2005): 4063-4071. http://www.scopus.com/inward/record.url?eid=2-s2.0-25144457713&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2005.06.004
  72. Mendes, P.J.; Prates Ramalho, J.P.; Candeias, A.J.E.; Robalo, M.P.; Garcia, M. H.. "Density functional theory calculations on ¿5- monocyclopentadienylnitrilecobalt complexes concerning their second-order nonlinear optical properties". Journal of Molecular Structure: THEOCHEM 729 1-2 SPEC. (2005): 109-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344445481&partnerID=MN8TOARS.
    Published • 10.1016/j.theochem.2004.12.048
  73. Wenseleers, W.; Goovaerts, E.; Hepp, P.; Garcia, M. H.; Robalo, M.P.; Dias, A.R.; Peidade, M.F.M.; Duarte, M.T.. "High first hyperpolarizability and perfectly aligned crystal packing for an organometallic compound [Fe(¿5-C5H5) ((R)-PROPHOS) (p-NCC6H4NO2)][PF6] · CH2CI2". Chemical Physics Letters 367 3-4 (2003): 390-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037420985&partnerID=MN8TOARS.
    Published • 10.1016/S0009-2614(02)01719-0
  74. Garcia, M. H.; Royer, S.; Robalo, M.P.; Romão Dias, A.; Tranchier, J.-P.; Chavignon, R.; Prim, D.; et al. "Synthesis, Characterisation of (Arene)tricarbonylchromium Complexes Linked to Cationic Fe and Ru Derivatives and Studies of First Hyperpolarisabilities by Hyper-Rayleigh Scattering". European Journal of Inorganic Chemistry 21 (2003): 3895-3904. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242459912&partnerID=MN8TOARS.
    Published
  75. Hudson, R.D.A.; Manning, A.R.; Gallagher, J.F.; Garcia, M. H.; Lopes, N.; Asselberghs, I.; Boxel, R.V.; Persoons, A.; Lough, A.J.. "Chiral organometallic chromophores for nonlinear optics derived from (µ-C-CH3)]+ [BF4]-". Journal of Organometallic Chemistry 655 1-2 (2002): 70-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036681316&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(02)01415-8
  76. Hudson, R.D.A.; Manning, A.R.; Gallagher, J.F.; Garcia, M. H.; Lopes, N.; Asselberghs, I.; Van Boxel, R.; Persoons, A.. "Synthesis, structure and nonlinear optical properties of some chiral chromophores derived from L-proline". Tetrahedron Letters 43 46 (2002): 8375-8378. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037064399&partnerID=MN8TOARS.
    Published • 10.1016/S0040-4039(02)02005-1
  77. Garcia, M. H.; Robalo, M. P.; Dias, A. R.; Duarte, M. T.; Wenseleers, W.; Aerts, G.; Goovaerts, E.; et al. "Synthesis and nonlinear optical properties of eta(5)-monocyclopentadienyliron(II) acetylide derivatives. X-ray crystal structures of Fe(eta(5)- C5H5)(DPPE)(p-C equivalent to CC6H4NO2) and Fe(eta(5)-C5H5)(DPPE)((E)-p-C equivalent to CC6H4C(H)=C(H)C6H4NO2)". Organometallics 21 10 (2002): 2107-2118.
    Published • 10.1021/om0104619
  78. Helena Garcia, M.; Rodrigues, J.C.; Romão Dias, A.; Piedade, M.F.M.; Teresa Duarte, M.; Paula Robalo, M.; Lopes, N.. "Second harmonic generation of ¿5-monocyclopentadienyl ruthenium p-benzonitrile derivatives by Kurtz powder technique. Crystal and molecular structure determinations of [Ru(¿5-C5H5)((+)-DIOP)(p-NCC 6H4NO2)][X], X=PF6 -, CF3SO3 -". Journal of Organometallic Chemistry 632 1-2 (2001): 133-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042910479&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(01)01041-5
  79. Dias, A.R.; Garcia, M. H.; Robalo, M.P.; Tekheira, A.P.S.; Bulygina, L.A.; Sokolov, V.I.. "Synthesis of cyclodextrin inclusion complexes with (¿-cyclopentadienyl)iron derivatives as potential nonlinear optics materials". Russian Journal of Organic Chemistry 37 5 (2001): 620-623. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035536468&partnerID=MN8TOARS.
    Published • 10.1023/A:1012475112315
  80. Dias, A.R.; Garcia, M. H.; Villa De Brito, M.J.; Galvão, A.. "Biscyclopentadienyl Group 6 metal complexes as metalloligands in the synthesis of heterobimetallic species. Crystal structures of new thiolato-bridged molybdenum(IV)-copper(I) complexes". Journal of Organometallic Chemistry 632 1-2 (2001): 75-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001793738&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(01)01047-6
  81. Garcia, M. H.; Robalo, M.P.; Dias, A.R.; Piedade, M.F.M.; Galvão, A.; Wenseleers, W.; Goovaerts, E.. "Organometallic complexes for second-order non-linear optics: Synthesis and molecular quadratic hyperpolarizabilities of ¿5-monocyclopentadienyliron(II) nitrile derivatives with different phosphines. X-ray crystal structure of [FeCp(DPPE)(p-NCC6H4NO2)][PF 6]·CH2Cl2". Journal of Organometallic Chemistry 619 1-2 (2001): 252-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000410611&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(00)00679-3
  82. Dias, A.R.; Galvão, A.; Garcia, M. H.; Villa De Brito, M.J.. "Synthesis and crystal structure of the novel trimanganese tetrathiolate incomplete cubane: [Mo(¿5-C5H5)2(H)CO][Mn 3(CO)9(µ-SC6H5)4]". Journal of Organometallic Chemistry 620 1-2 (2001): 276-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0010971110&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(00)00798-1
  83. Garcia, M. H.; Robalo, M. P.; Teixeira, A. P. S.; Dias, A. R.; Piedade, M. F. M.; Duarte, M. T.. "Synthesis of new donor/acceptor eta(5)-cyclopentadienyl and eta(5)-indenyliron(II) complexes with p-benzonitrile derivatives. Crystal structures of Fe(eta(5)-C5H5)(CO)(P(OC6H5)(3))(p-NCC6H4NO2) BF4 center dot CH2Cl2 and Fe(eta(5)-C9H7)(CO)(P(OC6H5)(3))(p-NCC6H4NO2) BF4". Journal of Organometallic Chemistry 632 1-2 (2001): 145-156.
    Published • 10.1016/s0022-328x(01)01039-7
  84. Dias, A. R.; Garcia, M. H.; de Piedade, M. F. M.; Carrondo, Maafd. "New studies on the chemical oxidation of bis(eta(5)-cyclopentadienyl)dithiolatemolybdenum(IV) complexes. Crystal structures of (Mo(eta(5)-C5H5)(2)S(C6H4-o-S)C6H5) BF4 and Mo(eta(5)-C5H5)(2)(SC6H5)(2)". Journal of Organometallic Chemistry 632 1-2 (2001): 107-112.
    Published • 10.1016/s0022-328x(01)01038-5
  85. Dias, A.R.; Garcia, M. H.; Mendes, P.; Piedade, M.F.M.; Duarte, M.T.; Calhorda, M.J.; Mealli, C.; et al. "Organometallic nickel(II) complexes with substituted benzonitrile ligands. Synthesis, electrochemical studies and non-linear optical properties. The X-ray crystal structure of [Ni(¿5-C5H5){P(C6H 5)3}(NCC6H4NH2)][PF 6]". Journal of Organometallic Chemistry 553 1-2 (1998): 115-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001444241&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(97)00645-1
  86. Wenseleers, W.; Gerbrandij, A.W.; Goovaerts, E.; Garcia, M. H.; Robalo, M.P.; Mendes, P.J.; Rodrigues, J.C.; Dias, A.R.. "Hyper-Rayleigh scattering study of ¿5-monocyclopentadienyl-metal complexes for second order non-linear optical materials". Journal of Materials Chemistry 8 4 (1998): 925-930. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001372029&partnerID=MN8TOARS.
    Published • 10.1039/a707556a
  87. Dias, A.R.; Duarte, M.T.; Galvão, A.M.; Garcia, M. H.; Marques, M.M.; Salema, M.S.; Masi, D.; Mealli, C.. "Uracil and thiouracil complexes of dicyclopentadienyl molybdenum and tungsten: Preparation and electrochemistry. The structures of [M(¿5-C5H5)2(2-SN 2OC4H3)][PF6], [M(¿5-C5H5)2{2-S(CH 3)N2OC4H2}][PF6],...". Polyhedron 14 5 (1995): 675-685. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038580753&partnerID=MN8TOARS.
    Published • 10.1016/0277-5387(94)00288-P
  88. Dias, A.R.; Garcia, M. H.; Rodrigues, J.C.; Petersen, J.C.; Bjørnholm, T.; Geisler, T.. "Third-harmonic generation in organometallic ruthenium(II) derivatives containing coordinated p-substituted benzonitriles". Journal of Materials Chemistry 5 11 (1995): 1861-1865. http://www.scopus.com/inward/record.url?eid=2-s2.0-0004531146&partnerID=MN8TOARS.
    Published
  89. C.T. Carrondo, M.A.A.F.d.; Dias, A.R.; Garcia, M. H.; Matias, P.; Piendade, M.F.M.; Villa de Brito, M.J.. "Indium(III) thiolate-bridged molybdenocene complexes: crystal structure of [InCl2MoCp2(¿-SEt) 22][BPh4] · (CH3)2CO". Journal of Organometallic Chemistry 466 1-2 (1994): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041377401&partnerID=MN8TOARS.
    Published • 10.1016/0022-328X(94)88042-5
  90. Dias, A.R.; Garcia, M. H.; Rodrigues, J.C.; Green, M.L.H.; Kuebler, S.M.. "Synthesis and characterization of ¿5-monocyclopentadienyl (p-nitrobenzonitrile)ruthenium(II) salts: Second harmonic generation powder efficiencies". Journal of Organometallic Chemistry 475 1-2 (1994): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000858841&partnerID=MN8TOARS.
    Published • 10.1016/0022-328X(94)84028-8
  91. Calhorda, M.J.; de C.T. Carrondo, M.A.A.F.; Dias, A.R.; FéIix, V.; Galvão, A.M.; Garcia, M. H.; Matias, P.M.; Villa de Brito, M.J.. "Synthesis, characterization and bonding of fulvalene dimolybdenum(III) and ditungsten(III) cations with one thiolate bridging ligand. Crystal structure of [Mo2(µ-¿5:...". Journal of Organometallic Chemistry 453 2 (1993): 231-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0009498237&partnerID=MN8TOARS.
    Published • 10.1016/0022-328X(93)83116-D
  92. Dias, A.R.; Garcia, M. H.; Robalo, M.P.; Green, M.L.H.; Lai, K.K.; Pulham, A.J.; Klueber, S.M.; Balavoine, G.. "Organometallic compounds for non-linear optics: Synthesis, reactivity and electrochemistry of chiral ¿5-monocyclopentadienyl(nitrile)iron complexes". Journal of Organometallic Chemistry 453 2 (1993): 241-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001432236&partnerID=MN8TOARS.
    Published • 10.1016/0022-328X(93)83117-E
  93. Calhorda, M.J.; de C.T. Carrondo, M.A.A.F.; Bram, A.; Olsen, P.N.; Dias, A.R.; Freitas, A.M.; Garcia, M. H.; Piedade, M.F.M.. "Electrochemistry and bonding in biscyclopentadienyl complexes of molybdenum, tungsten, and niobium with o-phenanthroline and bipyridine. Crystal an". Journal of Organometallic Chemistry 426 2 (1992): 195-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347356833&partnerID=MN8TOARS.
    Published
  94. Bandy, J.A.; Bunting, H.E.; Garcia, M.-H.; Green, M.L.H.; Marder, S.R.; Thompson, M.E.; Bloor, D.; et al. "Second-order non-linear optical properties of diironalkenylidyne complexes; crystal structure of {(¿-C5H5)2Fe2(CO)2(µ-CO)(µ-(E)CCHCHC6H4(p)-NMe2)}+BF4 -". Polyhedron 11 12 (1992): 1429-1435. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001610979&partnerID=MN8TOARS.
    10.1016/S0277-5387(00)83135-6
  95. Calhorda, M.J.; Carrondo, M.A.A.F.D.C.T.; Dias, A.R.; Galvão, A.M.; Garcia, M.H.; Martins, A.M.; Minas Da Piedade, M.E.; et al. "Syntheses, electrochemistry, and bonding of bis(cyclopentadienyl)molybdenum alkyl complexes. Molecular structure of Mo(¿5-C5H5)2(C4H 9)2. Thermochemistry of Mo(¿5-C5H5)2R2 and Mo(¿5-C5H5) ...". Organometallics 10 2 (1991): 483-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000909980&partnerID=MN8TOARS.
    10.1021/om00048a027
  96. de C.T. Carrondo, M.A.A.F.; Dias, A.R.; Garcia, M. H.; Matias, P.M.; Robalo, M.P.; Green, M.L.H.; Higgins, J.; Yang, Y.Y.. "Syntheses and reactivity of p-substituted benzonitrile complexes derived from dicyclopentadienyl-molybdenum and -tungsten. Oxidative electrochemistry. The crystal structure of [Mo(¿5-C5H5)2(SC6H5)(p-(CH3)2NC6H4CN)][PF6]". Journal of Organometallic Chemistry 395 3 (1990): 279-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040642631&partnerID=MN8TOARS.
    Published • 10.1016/0022-328X(90)85292-7
  97. De C.T. Carrondo, M.A.A.F.; Dias, A.R.; Garcia, M. H.; Mirpuri, A.; Fátima, M.; Piedade, M.; Salema, M.S.. "Mercaptopyridine complexes of dicyclopentadienylmolybdenum and -tungsten: Preparation and electrochemistry. The structure of [Mo(¿5-C5H5)2(2-SNC 5H4)][PF6]". Polyhedron 8 20 (1989): 2439-2447. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000565566&partnerID=MN8TOARS.
    Published • 10.1016/S0277-5387(89)80008-7
  98. Calhodra, M.J.; de C.T. Carrondo, M.A.A.F.; Garcia, M. H.; Hursthouse, M.B.. "The X-ray crystal structure of di-¿5-cyclopentadienylthiophenolatoamminemolybdenum(IV) hexafluorophosphate solvate [Mo(¿5-C5H5)2(NH3)(SC6H5)][PF6] · (CH32CO". Journal of Organometallic Chemistry 342 2 (1988): 209-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0039457249&partnerID=MN8TOARS.
    Published • 10.1016/S0022-328X(00)99458-0
  99. Dias, A. R.; Garcia, M. H.; Martins, A. M.; Pinheiro, C. I.; Romao, C. C.; Veiros, L. F.. "NEW MOLYBDENOCENE DIHYDROCARBYLS". Journal of Organometallic Chemistry 327 3 (1987): C59-C62.
    Published • 10.1016/s0022-328x(00)99758-4
  100. Calhorda, M. J.; Carrondo, Maafdt; Dias, A. R.; Domingos, A. M. T.; Duarte, Mtls; Garcia, M. H.; Romao, C. C.. "NITRILE COMPLEXES OF DICYCLOPENTADIENYL-MOLYBDENUM AND ETA-5-TUNGSTEN - PREPARATION AND REACTIVITY - THE STRUCTURE OF DI-ETA-5-CYCLOPENTADIENYLIODOACETONITRILE-MOLYBDENUM(IV) HEXAFLUOROPHOSPHATE, MO(ETA-5-C5H5)2I(NCCH3) PF6". Journal of Organometallic Chemistry 320 1 (1987): 63-81.
    Published • 10.1016/0022-328x(87)85080-5
  101. Kotz, J. C.; Vining, W.; Coco, W.; Rosen, R.; Dias, A. R.; Garcia, M. H.. "OXIDATIVE ELECTROCHEMISTRY OF COMPOUNDS OF THE TYPE (ETA-5-C5H5)2MX2 WHERE M = TI(IV), MO(IV), AND W(IV) AND X = HALIDE, THIOLATE, OR FERROCENYL". Organometallics 2 1 (1983): 68-79.
    Published • 10.1021/om00073a014
Newsletter article
  1. B. J. Herold; A. A. S. C. M. Machado; J. Cardoso; J. Marçalo; J. A. L. Costa; M. C. Magalhães; M. Helena Garcia; et al. "Hidretos Parentais, Nomenclatura Aditiva e Substitutiva … Serão apenas Nomes Novos para Conceitos Velhos?”", Química - Boletim da SPQ, 2011
  2. A. A. S. C. M. Machado; B. J. Herold; J. Cardoso; J. Marçalo; J. A. L. Costa; M. C. Magalhães; M. Helena Garcia; et al. "A história da nomenclatura química em português", Química - Boletim da SPQ , 2010
  3. A. A. S. C. M. Machado; B. J. Herold; J. Cardoso; J. Marçalo; J. A. L. Costa; M. C. Magalhães; M. Helena Garcia; et al. "Os nomes dos elementos químicos", Química - Boletim da SPQ, 2010
  4. A.R. Dias; M. Helena Garcia. "Electronic spectra of pseudo-tetrahedral Co(II) complexes with the organometallic ligands [M(¿5-C5H5)2(SR)2] (M=Mo, W)", Rev. Port. Quím., 1979
Online resource
  1. M. Helena Garcia. Paper selected by the Global Medical Discovery (onlinecontinuous dissemination): 2014 “Anticancer activity of structurally relatedruthenium(II) cyclopentadienyl complexes", Leonor Côrte-Real, Filipa Mendes,Joana Coimbra, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, M.Helena Garcia, Isabel Santos, Manuel Bicho, featured at Global MedicalDiscovery [ISSN 1929-8536].. 2014. https://globalmedicaldiscovery.com/?s=Anticancer+activity+of+structurally+related+ruthenium%28II%29+cyclopentadienyl+complexes.
  2. M. Helena Garcia. Paper selected by the Global Medical Discovery (onlinecontinuous dissemination): 2012 “[RuII( eta5-C5H5)(bipy)(PPh3)]+, a promisinglarge spectrum antitumor agent: cytotoxic activity and interaction withHuman Serum Albumin”, Ana Isabel Tomaz, Tamás Jakusch, Tânia S. Morais,Rodrigo F. M. de Almeida, Fernanda Marques, Filipa Mendes, Eva A. Enyedy,João Costa Pessoa, Támas Kiss, M. Helena Garcia.. 2012. http://globalmedicaldiscovery.com/key-scientific-articles/ruii%CE%B7%E2%81%B5-c%E2%82%85h%E2%82%85bipypph%E2%82%83%E2%81%BA-a-promising-large-spectrum-antitumor-agent-cytotoxic-activity-and-interaction-with-human-serum-albumin/.
Translation
  1. M. Helena Garcia. Nomenclatura em Química Inorgânica da IUPAC. Portugal: IST PRESS. 2018.
    Published

Intellectual property

Patent
  1. Garcia, Maria; Andreia Valente; Tânia S. Morais; Ana Isabel Tomaz. 2016. "Macromolecular transition metal complexes for treatment of cancer and process for their preparation". Portugal.
    Granted/Issued
  2. M. Helena Garcia; Andreia Valente; Tânia S. Morais (B61A-A9D4-08CC); Ana I. Tomaz. 2014. "Novos complexos macromoleculares de metais de transição para tratamento do cancro". Portugal.
    Granted/Issued
  3. Garcia, Maria; Tânia S. Morais; Ana Isabel Tomaz; Fernanda Marques. 2013. "Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands". Portugal.
    Expired
  4. Garcia, Maria; Tânia S. Morais; Ana Isabel Tomaz; Fernanda Marques; Filipa Mendes. 2013. "Transition metal complexes for pharmaceutical applications". Portugal.
    Expired
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02/22 From the text tube to the clinic: the search for a new anticancer agent (Invited) JorTec Bioquímica 2021_Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
(Portugal)
2020/11 Iron-cyclopentadienyl compounds with nitrile-based ligands show strong activity against a broad panel of human cancer cell lines 6th International Electronic Conference on Medicinal Chemistry, virtual conference
2020/02/05 “Ruthenium-peptide conjugates for the selective treatment of triple-negative breast cancer 17th Iberian Peptide Meeting (EPI 2020)
(Madrid, Spain)
2020/02 Ruthenium-cyclopentadienyl bipyridine-biotin based compound: P-gp inhibition and activity against resistant cancer cells STRATAGEM CA17104 Annual Conference, 3rd meeting and 4th WGs meeting
(Belgrade, Serbia)
2020/01/15 Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors 13º Encontro Nacional de Química Orgânica/6º Encontro Nacional de Química Terapêutica
(Aveiro, Portugal)
2019/12/02 Strategies for targeted cancer therapy using ruthenium-cyclopentadienyl complexes (invited) 3rd International Caparica Christmas Congress on Translational Chemistry 2019
(Caparica, Portugal)
2019/09/05 New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies To Fight Metastatic Breast Cancer (invited) 6th Young Medicinal Chemist Symposium (EFMC-YMCS 2019)
(Athens, Greece)
2019/06/24 Progress on the design of metal-based drugs for cancer therapy (invited) 6th World Congress on Natural Product & Synthetic Chemistry (Synthetic Chemistry 2019)
(New York, United States)
2018/11/21 Copper(I)-phosphane complexes as potencial anticancer agents XXIV Encontro Luso-Galego de Química
(Porto, Portugal)
2018/10/18 Synthesis and characterization of promising anticancer Cu(I) complexes FLASH PRESENTATION MMSE 2018 - Modern Methods of Structure Elucidation
(Lisbon, Portugal)
2018/07/05 Ruthenium Cyclopentadienyl Compounds: Cytotoxic Agents Against Resistant Cancer Cells 12th Inorganic and Bioinorganic Chemistry Conference
(Porto, Portugal)
2018/07/05 Ruthenium complexes as anticancer metallodrugs 12th Inorganic & Bioinorganic Chemistry Conference-12IBCC
(Porto, Portugal)
2018/03/01 Novel ruthenium cyclopentadienyl complexes bearing bipyridine based (macro)ligands with strong activity towards cancer cells 4th European Conference on Smart Inorganic Polymers
(Zagreb, Croatia)
2018 Novel ruthenium methylcyclopentadienyl complexes bearing bipyridine based ligands with strong anticancer activity International Conference on Coordination Chemistry
(Sendai, Japan)
2018 On the mode of action of anticancer ruthenium-polymer conjugates International Conference on Coordination Chemistry
(Sendai, Japan)
2017/12/04 ABC proteins: targets for ruthenium-cyclopentadienyl anticancer compounds? (Invited) II International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2017/12/04 Novel ruthenium-cyclopentadienyl complexes as potential candidates to surmount multidrug resistance in cancer UL Chemsitry PhD Meeting (2ECQUL), Reitoria da Universidade de Lisboa
(Lisboa, Portugal)
2017/12/04 Ruthenium complexes and their potential in cancer therapy 2nd International Caparica Christmas Congress on Translational Chemistry IC3TC
(Caparica, Portugal)
2017/08/06 Unprecedented polymer-metal vesicles as efficient anticancer agents´ (Invited) SILQCOM 2017
(Puerto Iguazú, Misiones, Argentina)
2017/07/31 On the mechanism of action of new active ruthenium anticancer compounds: a model membrane biophysics approach ICBIC18 – International Conference on Biological Inorganic Chemistry
(Florianópolis, Brazil)
2017/05/19 Ruthenium compounds as metallodrug candidates for cancer therapy (Invited) BIT’s 10th Annual World Cancer Congress
(Barcelona, Spain)
2017/02/09 New self-assembled polymer-metal compounds: highly efficient anticancer vesicles Chem&BioChem postgraduate students meeting
(Lisboa, Portugal)
2016/11/21 Ruthenium new drugs: a promising future in cancer therapy? (Invited) World Congress on Cancer Research & Therapy
(Miami, United States)
2016/11/21 Targeting cancer with new multifunctional metallodrugs (Invited) World Congress on Cancer Research & Therapy
(Miami, United States)
2016/06/16 Ruthenium Organometallic compounds as promising antimetastatic drugs for breast cancer chemotherapy (Invited) European Chemistry Congress
(Roma, Italy)
2016/06/16 Polymer-metal conjugates: versatile scaffolds for the synthesis of new antitumor drugs (Invited) European Chemistry Congress
(Roma, Italy)
2015/12/07 Multifunctional polymer-ruthenium cyclopentadienyl complexes: new promising anticancer agents (Invited) 1st International Caparica Christmas Congress on Translational Chemistry IC3TC
(Caparica, Lisboa, Portugal)
2015/12/07 Developing new ruthenium compounds as anti-tumor metallodrugs (Invited) 1st International Caparica Christmas Congress on Translational Chemistry IC3TC
(Caparica, Lisboa, Portugal)
2015/11/02 On the mode of action of new promising anticancer agents: multifunctional polymer-ruthenium conjugates (Invited) 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Atlanta, United States)
2015/11/02 Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances (Invited) 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Atlanta, United States)
2015/09/24 Multifunctional polymer-ruthenium conjugates: new promising anticancer agents 2nd European Conference on Smart Inorganic Polymers
(Upsalla, Sweden)
2015/06/12 New ruthenium cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13)
(Galway, Ireland)
2014/12/12 New compounds for cancer treatment (Invited) Symposium on Electron Microscopy: An Overview of Scientific Applications, Instituto Superior de Ciências da Saúde Egas Moniz
(Caparica, Lisboa, Portugal)
2014/12/08 Tracking antitumor drugs: ruthenium(II) cyclopentadienyl complexes as promising agents (Invited) 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(San Francisco, United States)
2014/12/08 Polymer ‘ruthenium-cyclopentadienyl’ conjugates: a new approach to fight cancer (Invited) 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(San Francisco, United States)
2014/10/22 Ruthenium-based anticancer compounds: Insights into their uptake mechanisms and cellular targets 4th World Congress on Cancer Science & Therapy
(Chicago, United States)
2014/02/12 Paving new ways for cancer therapy with Ruthenium Organometalic compounds (Invited) ChemForum -2014 Winter Edition, Centro de Química Estrutural, Instituto Superior Técnico
(Lisboa, Portugal)
2013/11/21 New polymer-ruthenium conjugates for targeted drug delivery in cancer chemotherapy Flash Presentation Nanoparticles for early Diagnostics of inflammatory diseases
(Lisboa, Portugal)
2013/10/15 On the field of metallodrugs– new ruthenium compounds as anti-tumor agents (Invited) 2nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing (MedChem&CADD 2013)
(Las Vegas, United States)
2013/10/15 New polymeric “ruthenium-cyclopentadienyl complexes for drug delivery in cancer therapy (Invited) 2nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing (MedChem&CADD 2013)
(Las Vegas, United States)
2013/09/17 Novel Pathways for Anticancer Therapy: the Role of Golgi network in the mechanism of cell death of organometallic complexes Microscopy at the Frontiers of Science, 2013: 3rd Joint Congress of the Portuguese and Spanish Microscopy Societies and Israel Society for Microscopy
(Tarragona, Spain)
2013/06/03 Paving New Ways For Cancer Therapy With Ruthenium Organometallic Compounds (Invited) Drug Discovery & Therapy", Symposium Hot Topics in Medicinal Chemistry
(Boston, United States)
2012/11/28 Promising organometallic ruthenium metallodrugs: RuII(h¿5-C5H5)(bipy)(PPh3)]+ a promising large spectrum antitumor agent 3rd National Meeting on Medicinal Chemistry (3ENQT)
(Aveiro, Portugal)
2012/09/24 Intracellular distribution of antitumor Ru(II) compounds: the lysossome and the lysosomal enzymes as targets for anticancer metal-based drugs XLVI Congress of the Portuguese Society for Microscopy 2012, Centro Hospitalar de Lisboa Central/Hospital D. Estefânia
(Lisboa, Portugal)
2012/09/03 Polydentate octhaedric Ruthenium complexes: synthesis, characterization, anti-tumour activity and interaction with human serum proteins Flash Presentation XXV International Conference on Organometallic Chemistry (XXV ICOMC)
(Lisboa, Portugal)
2012/06/18 New polydentate Ru(III)-Salan complexes: synthesis, characterization, anti-tumour activity and interaction with human serum proteins International Symposium on Metal Complexes (ISMEC 2012)
(Lisboa,, Portugal)
2011/08/31 A promising large spectrum new antitumor ruthenium agent: interaction with serum proteins ad mechanisms of cell death 4th European Conference on Chemistry for Life Sciences (4ECCLS)
(Budapeste, Hungary)
2011/07/03 Synthesis and cytotoxicity of new Ruthenium(II) complexes for anti-tumor application XXII Encontro Nacional da Sociedade Portuguesa de Química
(Braga, Portugal)
2010/10/06 Interaction of vanadium and vanadium complexes with human serum transferrin The 7th International Symposium on the Chemistry and Biochemistry of Vanadium, V7 Symposium
(Toyama, Japan)
2010/10/03 Second Order Nonlinear Optical Properties of Group 8 Half-Sandwich Organometallic Complexes (Invited) Symposium 14:"Non-Linear Optical Properties of Matter: From Molecules to Condensed Phases, International Conference of Computational Methods in Sciences and Engineering 2010 (ICCMSE 2010)
(Psalidi, Kos, Greece)
2010/05/18 Bioorganometallic Chemistry: an attractive field for the search of anticancer drugs (Invited) BIT`s 1st Annual International Conference of Medichem-2010
(Beijing, China)
2006/08/27 New Thiophene Functionalized Structures in View of Their Use as Ligands for NLO Properties (Invited) 4th Eurasian Meeting On Heterocyclic Chemistry
(Tessalónica, Greece)
2006/07/23 New Group 8 Organometallic Complexes in View of NLO Properties: Aiming a Better? (Invited) XXIInd International Conference on Organometallic Chemistry
(Saragoça, Spain)
2006/07/02 Organometallic Materials for Photonics and Molecular Electronics Nanoscale Devices Fourteenth International Conference on Composites/Nano Engineering (ICCE-14)
(Boulder, United States)
2005/06/08 Molecular First Hyperpolarizabilities of Pseudo-Octahedrally Coordinated Hydrideni-trileiron(II) Complexes Determined with Hyper-Rayleigh Scattering 5th International Conference on Photonics, Devices and Systems
(Praga, Czech Republic)
2005/04/10 Molecular First Hyperpolarizabilities of Pseudo-Octahedrally Coordinated Hydrideni-trileiron(II) Complexes Determined with Hyper-Rayleigh Scattering ECONOS 05 - European Conference on Nonlinear Optical Spectroscopy
(Oxford, United Kingdom)
2005/04/10 Complexes Determined with Hyper-Rayleigh Scattering ECONOS 05 - European Conference on Nonlinear Optical Spectroscopy
(Oxford, United Kingdom)
2005/03/31 Synthesis of New Ruthenium(II) and Iron(II) Organometallic Complexes in Helical Environments (Invited) VIth Conference in Inorganic Chemistry
(Funchal, Madeira, Portugal)
2005/03/31 Organometallic Chemistry: A Non-linear Optical Point of View (Invited Plenary) VIª Conferência de Química Inorgânica, Sociedade Portuguesa de Química
(Funchal, Madeira, Portugal)
2004/07/25 Synthesis of New Iron(II) Dihydroazulene Molecular Materials in view to Photochromic Properties XXIth ICOMC International Conference on Organometallic Chemistry
(Vancouver, Canada)
2003/06/11 Synthesis of New Ru(II)/Ru(III) and Fe(II)/Ru(III) Complexes in View of Nonlinear Optical Properties (Invited) 7th FIGIPS Meeting in Inorganic Chemistry
(Lisboa, Portugal)
2003/02/09 Design of Organometallic Nitrile and Acetylide Complexes for Second-Order Nonlinear Optics Optical Probes 2003- 5th International Topical Conference on Optical Probes of Conjugated Polymers and Organic & Inorganic Nanostructures
(Venice, Italy)
2002/02/21 Octahedral Complexes of Iron(II) Final Network Plenary Meeting: “Organometallic Dipoles with NLO Properties”
(Lisboa, Portugal)
2001/07/15 Nonlinear optical properties of organometallic complexes (Invited) 6th FIGIPS Meeting in Inorganic Chemistry
(Barcelona, Spain)
2001/04/06 Complexos Octaédricos de Ferro(II) com Benzonitrilos p-Substituídos: Síntese e Caracterização 5ª Conferência de Química Inorgânica, Soc. Port. de Química
(Monte Real, Portugal)
2000/04/12 Recent results on our Chemistry in view of NLO Properties (Invited) Mid Term Review Programme-Organometallic Dipoles with NLO Properties ERBFMRXCT-CT98-0166-Norwich
(Norwich, United Kingdom)
2000/04/12 New Organometallic Compounds for NLO Mid-Term Network Plenary Meeting: “Organometallic Dipoles with NLO Properties”
(Norwich, United Kingdom)
1999/12/07 Binuclear Compounds for NLO (Invited) TMR Plenary Meeting Leuven-Organometallic Dipoles with NLO Properties, ERBFMRXCT-CT98-0166
(Leuven, Belgium)
1999/07/11 New Isonitrile Ru(II) and Fe(II) Complexes for NLO Network Plenary Meeting: “Organometallic Dipoles with NLO Properties”
(Hamburgo, Germany)
1999/07/09 Binuclear Compounds for NLO (Invited) TMR Plenary Meeting Hamburg-Organometallic Dipoles with NLO Properties-ERBFMRXCT-CT98-166
(Hamburg, Germany)
1998/09/22 Organometallic materials for non-linear optics (Invited) XXIst Polish-German Colloquy on Organometallic Chemistry
(Poland)
1998/09/05 Cyclic voltammetry as a technique to assess reactivity and structural features on organometallic compounds (Invited) Post-ICCC Meeeting on Electrochemistry of Coordination and organometallic Compounds
(Siena, Italy)
1998/05/18 Organometallic materials for non-linear optics (Invited) Conference of Organometallic Chemistry on the Eve of 21st Century
(INEOS, Russia)
1998/02/18 A Química Organometálica Nos Computadores Do Futuro (Invited) Agostinho Lourenço Seminar, FCUL
(Lisboa, Portugal)
1997/11/13 Synthesis of new included cyclodextrine organometallic complexes in view of their nonlinear optical properties (Invited) A. N. Nesmeyenov Institute of Organoelements Compounds from Russian Academic Sciences
(Moscovo, Russia)
1997/10 Minisymposium: asymetric synthesis and catalysis (Invited) 4th FGIPS Meeting in Inorganic Chemistry
(Corfu, Greece)
1997/09/05 Nonlinear optical properties of donor-acceptor based organonitrile complexes of monocyclopentadienyl transition metals XIInd FECHEM Conference on Organometallic Chemistry
(Praga, Czech Republic)
1997/07/08 Large First Hyperpolarisabilities of h¿5-Monocyclopentadienyl Metal Complexes Measured by Hyper-Rayleigh-Scattering 11th Topical Meeting of the European Optical Society, “Materials for Nonlinear Optics”
(Italy)
1996/09/08 Synthesis of organometallic compounds containing Fe(II), Ru(II), Ni(II) and Co(III) for nonlinear optical properties Human Capital Mobility: Novel Third Order NLO Molecular Materials
(Mons, Belgium)
1996/07/07 Synthesis of new molecular materials containing electron-donor organometallic fragments XVIIth International Conference Organometallic Chemistry
(Brisbane, Australia)
1996/05/22 Compostos opticamente nao-lineares nos computadores do futuro (Invited) XV Encontro Nacional da Sociedade Portuguesa de Química
(Portugal)
1995/09/07 Synthesis of NLO organometallic molecular materials Human Capital Mobility: Novel Third Order NLO Molecular Materials”
(Copenhaga, Denmark)
1995/06/09 Development on the synthesis of new organometallic materials in view of their non-linear optical properties (Invited) 3rd GIPS Meeting in Inorganic Chemistry
(Senigallia, Italy)
1995/04/24 Redox chemistry of metallocene bisthiolate [MCp2(SR)2] M=Mo(IV), W(IV)” V Congreso Iberoamericano de Química Inorgânica y XII Congresso Mexicano de Química Inorgânica
(Saltillo, Mexico)
1994/09/14 Synthesis of organometallic compounds for nonlinear optical properties Human Capital Mobility: Novel Third Order NLO Molecular Materials”
(Cambridge, United Kingdom)
1994/05/27 Synthesis of organometallic compounds for second order nonlinear optical properties (Invited) Workshop INEOS-94-The Modern Problems of Organometallic Chemistry
(Moscovo, Russia)
1993/12 Synthesis of New Organometallic Materials for Nonlinearities; Second and Third Harmonic Generation (Invited) Human Capital Mobility Network Meeting
(Londres, United Kingdom)
1993/05/07 Síntese, Electroquímica e Estrutura Molecular do [h¿5-C5H5)Fe(DPPE)(p-NCC6H4NO2)][PF6] 1ª Conferência de Química Inorgânica, Sociedade Portuguesa de Química
(Águeda, Portugal)
1992 Compostos organometálicos opticamente não lineares (Invited) Encontro Anual da Sociedade Portuguesa de Química
(Lisboa, Portugal)
1991/11/11 Organometallic iron(II) compounds on view of nonlinear optical properties Fifth International Kyoto Conference on New Aspects of Organic Chemistry
(Kyoto, Japan)
1990/06/24 Polynuclear compounds with MCp2(SR)2 as ligands M=Mo(IV), W(IV) (Invited) Italian-Portuguese-Spanish Meeting in Inorganic Chemistry
(Gandia, Spain)
1990/05 Design and Synthesis of Organometallic Compounds in View of Their Non-linear Optical Properties -A Review on the Field (Invited) Crystallographic Department, University of Koln
(Koln, Germany)
1988/11 Voltametria Cíclica de Compostos Organometálicos (Invited) LNETI
(Lisboa, Portugal)
1988/10 Electroquímica de Complexos Derivados de NiCp+ com Sulfonas Coordenadas (Invited) Centro de Química Estrutural, Instituto Superior Técnico, Lisboa
(Lisboa, Portugal)
1988/09/04 Synthesis and reactivity of the complexes [MCp2(SR)(NCR)][PF6] (M=Mo(IV), W(IV); R=aryl derivative) XIII International Conference on Organometallic Chemistry
(Turim, Italy)
1986/10 Síntese de Novos Compostos Organometálicos com vista às suas Propriedades de Nao-linearidade Óptica (Invited) Complexo Interdisciplinar, Instituto Superior Técnico, Lisboa
(Lisboa, Portugal)
1983 Mecanismos de Reacções em Química Organometálica (Invited) Universidade Nova de Lisboa
(Lisboa, Portugal)
1980/10 Oxidativa de [MCp2(SR)2] (M=Mo(IV), W(IV)) e Compostos Derivados (Invited) Complexo Interdisciplinar, Instituto Superior Técnico, Lisboa
(Lisboa, Portugal)
1979/04 Cromatografia - Uma Técnica Simples de Separação (Invited) Ciclo de Conferências Convidadas, Sociedade Portuguesa de Química, Lisboa
(Lisboa, Portugal)
1979/01 Extractos de Plantas como Indicadores de pH (Invited) Ciclo de Conferências Convidadas, Sociedade Portuguesa de Química, Lisboa
(Lisboa, Portugal)
1978 Electronic spectra of pseudo-tetrahedral Co(II) complexes with the ligands [MCp2(SR)2] (M=Mo, W) Iº Encontro Nacional da Sociedade Portuguesa de Química
(Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2014/03 - 2019/04 Targeting tumors with innovative metal peptide complexes: improving efficacy in anticancer drugs
Supervisor of Tãnia S. Morais
 Post Doc (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2019 Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation
Supervisor of Leonor Côrte-Real
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2018 Estudo do Comportamento em fase gasosa de princípios activos de produtos fitofarmacêuticos com vista à construção de uma biblioteca de espectros de MS2
Co-supervisor of Vera Lúcia Santos Martins
 Química Tecnológica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2015 Gallium Compounds for the Design of (Nano)Radiopharmaceuticals
Co-supervisor of Francisco França Alcantara Conceição Silva
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2015 Avaliação do Potencial Clínico de Novos Ligandos para o Receptor Estrogénico em Diagnóstico e Terapia de Tumores da Mama
Co-supervisor of Susana Manuela Pereira da Cunha
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2014 Organometallic complexes of Tc I and Re I for radiometalation of biologically active peptides
Co-supervisor of Mariana Rute Nogueira Pinto
 Química Tecnológica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/04 - 2013/12 Polymeric Metal Complexes: New antitumoral agents with applications
Supervisor of Andreia Valente
 Post-doc (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009/11 - 2013/12 Síntese de Novos Complexos Bioorganometálicos de Ruténio e Avaliação das Suas Propriedades Anti-tumorais
Supervisor of Tânia Sofia Ferreira Morais
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2013 Re and 99m Tc tricarbonyl probes for target-specific detection of melanoma and sentinel lymph node
Co-supervisor of Mauricio da Silva Morais
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/11 - 2012/04 Synthesis of new compounds with non-linear optic activity
Supervisor of Andreia Valente
 Post-doc (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2012 Complexos de Ruténio como Potenciais Agentes Terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicos
Supervisor of Leonor de Sá Nogueira Corte-Real
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2012 Síntese de novos compostos organometálicos de Fe(II): estudos das suas potencialidades como agentes anticancerígenos
Supervisor of Cristina Gonçalves
 Química Inorgânica Biomedica- Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Copper compounds (Schiff bases) as DNA-Interacting Agents
Co-supervisor of Rosa Brissos
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 para-Cymene Ruthenium Complexes as Catalysts
Co-supervisor of Joel David Avelino Fonseca
 Química Tecnológica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Recruitment of PyK2 during complement mediated phagocytosis and expression of kinase domains in insect cell
Supervisor of Carina Dinis Santos
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Desarrollo de compuestos citotóxicos de rutenio com potencial para applicaciones terapéuticas
Co-supervisor of Oscar Armando Lenis Rojas
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2010 Synthesis and study of metallo-organic compounds for second-order NLO molecular switching
Supervisor of Tiago Jorge Laranjeira Silva
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Estudo de interacção com o DNA de novos compostos derivados de ciclopentadienilo de Ferro(II) e de Ruténio(II) com ligandos doadores N,S
Supervisor of Cristina Gonçalves
 Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Síntese de Compostos organometálicos de ferro (II) como agentes com potencialidades anti--- tumorais. Estudos biológicos de complexos de ruténio(II)
Supervisor of Marta Pacheco Botelho Mourão
 Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2010 Lanthanide based coordinative chain transfer polymerization for architecture control in (co)polymers and Ruthenium catalyzed ring---opening polymerization: two aspects of atom economy in polymerization catalysis
Co-supervisor of Andreia Valente
Universidade de Lille , France
2007/09 - 2009/06 Complexos de Vanádio e de Ruténio para aplicação anti-tumoral
Supervisor of Ana Isabel Tomaz
 Post-doc (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2009 Síntese de complexos organometálicos com potencialidades como agentes anti-tumorais
Supervisor of Milan Chhaganlal
 Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2009 Síntese de complexos organometálicos com potencialidades como agentes anti-tumorais
Supervisor of Ana Margarida Ganhão Guerreiro dos Santos
 Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2009 Síntese de Compostos Organicos e Organometálicos com Potenciais Aplicações em Óptica Não Linear
Co-supervisor of Cristina Isabel Costa Jacob
 Química (PhD)
Universidade de Lisboa, Portugal
2007/10 - 2008/06 Síntese e caracterização de complexos organometálicos Citotóxicos derivados do fragmento “CpRu” e avaliação das suas potencialidades como agentes anti-tumorais
Supervisor of Tânia Sofia Ferreira Morais
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2008 Síntese e caracterização de complexos de Pd(II) e Pt(II) e estudo da sua interacção com o DNA
Co-supervisor of Cristina Pereira de Matos
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2008 Síntese de Compostos Organometálicos com Potencial Aplicação em Óptica Não Linear
Supervisor of Pedro Ricardo da Rocha Florindo
 Química (PhD)
Universidade de Lisboa, Portugal
2006 - 2007 Síntese e caracterização de complexos organometálicos de Ru(II) com vista às suas potencialidades como agentes citotóxicos
Supervisor of João Pedro Almeida Santos Ribeiro
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2006 - 2007 Síntese de metalocenos de ruténio e avaliação das suas potencialidades antitumorais
Supervisor of Andreia Marques Valente
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2006 - 2007 Síntese e caracterização de compostos organometálicos de Ru(II) e Fe(II) com ligandos azotados. Estudo preliminar sobre as suas potencialidades como agentes antitumorais
Supervisor of Tânia Sofia Ferreira Morais
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005 - 2006 Complejos de rutenio(II): síntesis, caracterización estructural, ensayos de reactividad con el DNA y comportamiento antiproliferativo
Supervisor of Montserrat Montaña
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2005 Síntese de novos complexos de permetil-ciclopentadienilo Ruténio(II)
Supervisor of Flavia Barragán Claver
Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2004 Tricarbonyl Complexes for the Design of Specific Radiopharmaceuticals for Endogenous Gene Expression and Membrane Receptor Imaging
Co-supervisor of Catarina Alexandra Henriques Xavier
 Química (PhD)
Universidade de Lisboa, Portugal
2004 - 2004 Copper, Samarium and Holmium Complexes with Tetraazamacrocycles Potentially Interesting for Nuclear Medicine
Co-supervisor of Sara Martins Vasco de Lacerda
 Química (PhD)
Universidade de Lisboa, Portugal
2003 - 2004 Síntesis de Nuevos Compuestos Organobimetálicos de RuIII/FeII
Supervisor of Ana Cabalo Brea
 Química
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2004 Síntese de compostos binucleares de Ru(II)
Supervisor of Diego Garrido
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
1999 - 2004 Complexos organometálicos de Re e Tc com propriedades osteotrópicas para imagiologia e/ou terapia.
Co-supervisor of Elisa Vaz Morgado de Palma
 Química (PhD)
Universidade de Lisboa, Portugal
2002 - 2003 Síntese de Compostos de ruténio com vista a propriedades de NLO
Supervisor of Pedro Florindo
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2002 Síntese de Compostos Organometálicos com Potenciais Aplicações em Óptica Não Linear
Supervisor of Paulo Jorge Gomes Mendes
 Química (PhD)
Universidade de Lisboa, Portugal
2001 - 2002 Organometallic Dipoles with NLO Properties (TMR Network ERB4061PL970101 (Human Capital and Mobility Program))
Supervisor of Simon Simpkins
 Post-Doc (Other)
University of East Anglia, United Kingdom
2001 - 2002 Síntese de novos compostos mono e binucleares de Ru(II) e Ru(III)
Supervisor of Alexandra Isabel André Domingos
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
1999 - 1999 Síntese de Novos Materiais Organometálicos com Propriedades de Não Linearidade Óptica
Supervisor of João Manuel Cunha Rodrigues
 Química (PhD)
Universidade de Lisboa, Portugal
1997 - 1998 Síntese e caracterização de ligandos orgânicos e sua coordenação a centros metálicos
Supervisor of Cristina de Jesus Alves Martins
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
1996 - 1997 Síntese de bis e tristiofeno e estudo de algumas reacções de funcionalização
Supervisor of José Alexandre A. F. Dias
Universidade de Lisboa Faculdade de Ciências, Portugal
1995/12 - 1996/05 New Third Order NLO Molecular Materials (network nº ERB CHRXCT 9330334 Human Capital and Mobility Program)
Supervisor of Jörg Kleinwächter
 Post-doc (Other)
Universität Hamburg, Germany
1990 - 1995 Síntese de Compostos Organometálicos Polinucleares
Co-supervisor of Maria José Afonso Villa de Brito
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
1990 - 1995 Síntese e Caracterização de Compostos Organometálicos por Difracção de Raios X
Co-supervisor of Maria de Fátima Minas da Piedade
Universidade de Lisboa Faculdade de Ciências, Portugal
1988 - 1993 Síntese de Compostos Organometálicos com vista à Propriedade de Nao-linearidade Óptica
Supervisor of Maria Paula Alves Robalo
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
1999 - Current XIIIth FECHEM Conference on Organometallic Chemistry (Secretary) (1999)
Conference
1997 - Current 3ª Conferência de Química Inorgânica da SPQ, Fátima, Portugal (1997)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2011/07/16 - 2011/07/20 “7th Review Conference of the States Parties to the Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on their Destruction (BWC/CONF.VII/7), ONU, Genebra, in representation of DQB-FCUL.

Association member

Society Organization name Role
1995 - 1997 President of the SPQ Inorganic Chemistry Division President

Committee member

Activity description
Role 		Institution / Organization
1992 - 2017 Member of EuChems International Scientific Committee
Member
1992 - 2017 Member of the “Organometallic Chemistry Division” of the European Association for Chemical and Molecular Sciences (Delegate of the Portuguese Chemical Society)
Member
Distinctions

Award

2020 Best Oral Communication in Therapeutic Chemistry Prize: Leonor Côrte-Real, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente, "Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors",
13º Encontro Nacional de Química Orgânica/6º Encontro Nacional de Química Terapêutica, Portugal
2017 Best poster prize-P. Girio, A. Moreno, M. H. Garcia, P. Falson, A. Valente, “ABC proteins: targets for ruthenium -cyclopentadienyl anticancer metallodrugs?”, V Encontro Nacional De Estudantes De Química, Coimbra, Portugal
European Young Chemists Network, United Kingdom
2017 Best oral communication - L. Corte-Real, A. P. Soto, A. S. Viana, A. R. Fernandes, M. H. Garcia, A. Valente, “New self-assembled polymer-metal compounds: highly eficiente anticancer vesicles”, Chem&BioChem postgraduate students meeting, Lisboa, Portugal.
2015 ScienceIN2Business Initiative, TecLabs for Translational Research, 2015 (M. HelenaGarcia, Andreia Valente, Tânia S. Morais, A. Isabel Tomaz, "Rupharma")
TecLabs, Portugal
2014 PhD Supervisor of Tânia Morais awarded the “Portuguese Young Chemist Award 2014 (PYC-Gradiva 2014) prize ”attributed by the Portuguese Chemical Society to the work“ New compounds, big challenges ”. PhD thesis: "Synthesis of new bioorganometallic rutheni
2013 Best poster prize - Drug Discovery & Therapy World Congress, 2013, M. HelenaGarcia, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Fernanda Marques,“Cyclopentadienyl ruthenium (macro)metallodrugs: large spectrum antitumor agents”
Drug Discovery & Therapy World Congress, United States
2012 Amadeu Dias Prize awarded to undergraduate student Guilherme Nogueira with the project entitled “New ruthenium-polymer complexes syntheses for controlled drug delivery in cancer therapy”, proposed under the guidance of M. H. Garcia.

Other distinction

2008 Honorable mention attributed to M. H. Garcia, “Potenciais Fármacos de Ruténio para o tratamento do cancro”, SHIC´08, SOLVAY & HOVIONE IDEAS CHALLENGE