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Olga Sin is an alumnus of the GABBA doctoral program (2009) from the University of Porto and has a Ph.D. in neurosciences from the University of Groningen (The Netherlands). Her research focused on finding genetic modifiers of protein aggregation in humanized models of neurodegenerative diseases. During her post-doc at the Max Plack Institute for Molecular Biomedicine (Germany) and University of Bern (Switzerland) she was awarded both the Dutch Rubicon Post-Doctoral Fellowship and the Marie Sklodowska-Curie Individual Fellowship. during this period her research focused on the unexplored relationship between protein aggregation and RNA homeostasis and its impact on neurodegenerative diseases. In 2022, she switched careers to Project Manager of the NCBio ERA Chair project. First, ensures the project’s deliverables are executed and she identifies, prepares and submits applications together with the ERA Chair Holder. Second, she is responsible for establishing relationships with clinicians, health industry and patient groups via the NCBio Stakeholder Hub. Finally, she collaborates with the Communications Unit of the i3S to disseminate neuroscience to the general public.
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Identification

Personal identification

Full name
Olga Sin

Citation names

  • Sin, Olga
  • Sin, O

Author identifiers

Ciência ID
541D-01E9-5833
ORCID iD
0000-0002-0976-0570
Scopus Author Id
56046384500

Email addresses

  • olga.sin@i3s.up.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2011/11 - 2015/12
Concluded
 Graduate Program in Biomedical Sciences (Doctor of Philosophy)
Major in Neurosciences
Rijksuniversiteit Groningen, Netherlands
2010/01 - 2015/12
Concluded
 Programa Doutoral em Biologia Básica e Aplicada (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007/09 - 2009/07
Concluded
 Neurociências (Mestrado integrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2004/09 - 2007/07
Concluded
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2022/08 - Current Science and Technology Management Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/05 - 2022/07 Contracted Researcher (Research) Universität Bern Departement für Chemie und Biochemie, Switzerland
2017/05 - 2019/04 Contracted Researcher (Research) Max Planck Institute for Molecular Biomedicine, Germany
2011/11 - 2015/12 Contracted Researcher (Research) Rijksuniversiteit Groningen, Netherlands
European Research Institute for the Biology of Ageing, Netherlands
Projects

Grant

Designation Funders
2017/03 - Current Elucidating the role of tRNA processing and modifications in proteostasis.
019.162LW.028
 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
2018/09 - 2020/08 The role of tRNA processing and modifications in protein quality control.
746340
 European Commission
2010/02 - 2013/07 From phosphorylation to cleavage: switching on alpha-synuclein aggregation and toxicity
Provided by PTCRIS: 105215
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. "Analysis of codon-specific translation by ribosome profiling". 191-223. Elsevier, 2021.
    10.1016/bs.mie.2021.06.025
Journal article
  1. Esther Stroo; Janssen L.; Olga Sin; Wytse Hogewerf; Mirjam Koster; Liesbeth Harkema; Sameh A Youssef; et al. "Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain". Life Science Alliance (2023): http://dx.doi.org/10.26508/lsa.202201730.
    10.26508/lsa.202201730
  2. Sandra Rode; Henrike Ohm; Lea Anhäuser; Marina Wagner; Mechthild Rosing; Xiaobing Deng; Olga Sin; et al. "Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila". Cell Reports 24 9 (2018): 2287-2299.e4. https://doi.org/10.1016%2Fj.celrep.2018.07.074.
    10.1016/j.celrep.2018.07.074
  3. Francesca Rapino; Sylvain Delaunay; Florian Rambow; Zhaoli Zhou; Lars Tharun; Pascal De Tullio; Olga Sin; et al. "Codon-specific translation reprogramming promotes resistance to targeted therapy". Nature 558 7711 (2018): 605-609. https://doi.org/10.1038%2Fs41586-018-0243-7.
    10.1038/s41586-018-0243-7
  4. Olga Sin; Tristan de Jong; Alejandro Mata-Cabana; Michelle Kudron; Mohamad Amr Zaini; Francesco A. Aprile; Renée I. Seinstra; et al. "Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation". Molecular Cell 65 6 (2017): 1096-1108.e6. https://doi.org/10.1016%2Fj.molcel.2017.02.022.
    10.1016/j.molcel.2017.02.022
  5. Olga Sin; Ellen A. A. Nollen. "Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes". Cellular and Molecular Life Sciences 72 21 (2015): 4027-4047. https://doi.org/10.1007%2Fs00018-015-1985-0.
    10.1007/s00018-015-1985-0
  6. Olga Sin; Helen Michels; Ellen A.A. Nollen. "Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842 10 (2014): 1951-1959. https://doi.org/10.1016%2Fj.bbadis.2014.01.015.
    10.1016/j.bbadis.2014.01.015
  7. "Topic 10. Yeasts as models for ageing & human diseases". Yeast 26 S1 (2009): S176-S195. https://doi.org/10.1002%2Fyea.1693.
    10.1002/yea.1693
  8. Fleming-Outeiro Tiago. "Unraveling the role of A-synuclein phosphorylation in the etiology of parkinson's disease". Frontiers in Neuroscience 3 (2009): https://doi.org/10.3389%2Fconf.neuro.01.2009.11.038.
    10.3389/conf.neuro.01.2009.11.038
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Unraveling the translational landscape of tRNA modification enzyme Mod5 NCCR RNA & Disease Retreat
(Kandersteg, Switzerland)
2017 Protein aggregation at the Gordon Research Conference: Stress proteins in Growth, Development & Disease Gordon Research Conference: Stress proteins in Growth, Development & Disease
(Lucca, Barga, Italy)
2014 Identification of MOAG-2/LIR-3 as a transcription factor regulating protein aggregation Dutch Worm Meeting, Groningen
(Groningen, Netherlands)
2014 Identification of MOAG-2/LIR-3 as a transcription factor regulating protein aggregation Dutch Chaperone Meeting
(Groningen, Netherlands)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06/30 - 2023/06/30 Neural Cell Biology (NCBio) Stakeholder Hub Kick-Off Meeting (2023/06/30 - 2023/06/30)
Conference (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/11/04 - 2022/11/04 Organization of the Meeting of i3S Program of Neurobiology and Neurologic Diseases (2022/11/04 - 2022/11/04)
Conference (Co-organisor)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/10/18 - 2022/10/18 Organization of the VI Portuguese Glia Meeting at the i3S Porto, Portugal (2022/10/18 - 2022/10/18)
Conference (Co-organisor)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013 - 2013 2nd Groningen PhD Day, University of Groningen, (2013 - 2013)
Congress (Member of the Organising Committee)
 Rijksuniversiteit Groningen, Netherlands
2012 - 2012 1st Groningen PhD Day, University of Groningen, The Netherlands (2012 - 2012)
Congress (Member of the Organising Committee)
 Rijksuniversiteit Groningen, Netherlands

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020 - 2020 Poster Presentation at the Swiss RNA Workshop, Bern, Switzerland
Conference
 Swiss RNA Workshop, Bern, Switzerland
Universität Bern, Switzerland
2019 - 2019 Poster presentation at the Gordon Research Conference: Stress proteins in Growth, Development & Disease
Conference
 Gordon Research Conference: Stress proteins in Growth, Development & Disease
2017 - 2017 Poster presentation at the EMBO Workshop on Proteostasis, Ericeira, Portugal
Conference
 EMBO Workshop on Proteostasis
2016 - 2016 Poster Presentation at the RNA Biochemistry Meeting, Bonn, Germany
Conference
 RNA Biochemistry Meeting
2015 - 2015 Poster presentation at the 1st Molecular Biology of Ageing Meeting, Groningen, The Netherlands
Conference
 1st Molecular Biology of Ageing Meeting
European Research Institute for the Biology of Ageing, Netherlands
2015 - 2015 Poster presentation at the 20th International C. elegans Meeting, Los Angeles, USA
Conference
 The 20th International C. elegans Meeting
Cold Spring Harbor Laboratory, United States
2014 - 2014 Poster presentation at the European Worm Meeting, Berlin, Germany
Conference
 European Worm Meeting, Berlin, Germany
2011 - 2011 Poster presentation at the 1st Dutch Huntington Symposium, Groningen, The Netherlands
Conference
 1st Dutch Huntington Symposium, Groningen, The Netherlands
2010 - 2010 Poster presentation at the Gordon Research Conference: CAG Triplet Repeat Disorders, Lucca, Italy
Conference
 Gordon Research Conference: CAG Triplet Repeat Disorders, Lucca, Italy
2009 - 2009 Poster presentation at the 11th Meeting of the Portuguese Society for Neurosciences, Braga, Portugal
Conference
 11th Meeting of the Portuguese Society for Neurosciences, Braga, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - 2021 Biochemistry I practical course for B.Sc. Biology, Chemistry and Biochemistry B.Sc. Biology, Chemistry and Biochemistry (Bachelor) Universität Bern, Switzerland
2017 - 2017 Model Systems in Biomedical Research (Master) Universitätsklinikum Münster, Germany
2015 - 2016 Human Genetics Human Genetics (Doutoramento) Universidade do Porto, Portugal
2014 - 2014 Molecular Mechanisms of Ageing 2nd COST Summer School (Bachelor) Rijksuniversiteit Groningen, Netherlands
2013 - 2014 C. elegans as a model organism Genes and Behavior (Bachelor) Rijksuniversiteit Groningen, Netherlands
2011 - 2014 C. elegans as a model organism Topmaster Medical and Pharmaceutical Drug Innovation program Rijksuniversiteit Groningen, Netherlands

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017/05/17 Famelab Germany Final, Bielefeld, Germany Macau Daily Times
2017/04/28 FameLab Germany final, Bielefeld, Germany Westfalen Blatt
2017/03/24 FameLab Germany regional heat, Bielefeld, Germany Westfalen Blatt

Other jury / evaluation

Activity description Institution / Organization
2017 - 2022 MINT-EC SchoolSlam (network of STEM schools) British Council Germany, Germany
Distinctions

Award

2020 COMET Career-building program for Excellent Female Postdocs of the University of Bern
Universität Bern, Switzerland
2019 Max Gruber Prize for best peer reviewed publication in Biochemistry or Cell Biology
Rijksuniversiteit Groningen, Netherlands
2017 Rubicon Postdoctoral Fellowship
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Netherlands
2017 Marie Sklodowska-Curie Postdoctoral Fellowship
European Commission, Belgium
2016 Cells-in-Motion Pilot Project
Max-Planck-Institut für molekulare Biomedizin, Germany
2016 Selected participant for the Sign Up! Career-building Program for Excellent Female Postdocs of the Max Planck Society
Max-Planck-Institut für molekulare Biomedizin, Germany
2015 Simonsfonds travel grant
Simons Foundation, United States
2010 PhD Fellowship from the Graduate Program in Areas of Basic and Applied Biology
Universidade do Porto, Portugal
2009 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2018 Selected young researcher for participation at the 68th Lindau Nobel Laureate Meeting