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Ana Raquel Pereira Santos holds a bachelor degree in Biochemistry (Faculty of Science and Technology of University of Coimbra) and a Master degree in Biomedical Research, specializing in Infection and Immunity (Faculty of Medicine of University of Coimbra). Throughout her academic path, her main areas of research were immunity, inflammation, microbiology and neurosciences. She has published 6 scientific papers and 1 book chapter as a co-author. She is currently enrolled in the PhD programme in Experimental Biology and Biomedicine (University of Coimbra), developing her work at the Gut-Brain Axis Group from the Center for Neuroscience and Cell Biology (University of Coimbra).
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Identification

Personal identification

Full name
Ana Raquel Pereira Santos

Citation names

  • Santos, R.
  • Pereira-Santos, AR.

Author identifiers

Ciência ID
5610-49AF-B580
ORCID iD
0000-0002-1595-3360

Email addresses

  • araqpsantos@gmail.com (Professional)
  • arsantos@cnc.uc.pt (Professional)

Addresses

  • Faculdade de Medicina da Universidade de Coimbra, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/01 - 2025/01
Ongoing
 PhD Programme in Experimental Biology and Biomedicine (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/03/07 - 2023/03/08
Concluded
 FLOW CYTOMETRY AND CELL SORTING - From Basic Concepts to Artificial Intelligence applied to Data Analysis (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/01/07 - 2019/01/18
Concluded
 II Modular Training in Laboratory Animal Science, function a) with special skills (Outros)
CNC.IBILI, Portugal
 17,3/20
2016/09 - 2018/09
Concluded
 Master Degree in Biomedical Research (Mestrado)
Major in Infection and Immunity
Universidade de Coimbra Faculdade de Medicina, Portugal
""The role of LSD1/CoREST complex during Hemogenic Reprogramming"" (THESIS/DISSERTATION)
 18,3/20
2012/09 - 2016/05
Concluded
 Bachelor degree in Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Quantification of S-Adenosylmethionine, S-adenosylhomocysteine and Acetyl CoA in doxorubicin-treated H9c2 by HPLC" (THESIS/DISSERTATION)
 14,3/20
Affiliation

Science

Category
Host institution 		Employer
2020/02/01 - 2020/05/17 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/15 - 2019/12/14 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09/01 - 2019/02/28 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2021/01 - Current PhD Student at Gut-Brain Axis Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/05/18 - 2020/12/21 Laboratory Technician at COVID-19 UC Laboratory Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2017/07 - 2018/09 Master Student at the Cell Reprogramming and Developmental Hematopoiesis Lab Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/05 - 2016/08 Internship in the Ubiquitin-dependent proteolysis and intercellular communication Group ICBR - Coimbra Institute for Clinical and Biomedical Research, Portugal
ICBR - Coimbra Institute for Clinical and Biomedical Research, Portugal
2015/07 - 2015/08 Internship at the MITOXT - Mitochondrial Toxicity and Experimental Therapeutics Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/02 - 2015/06 Bachelor Student at the MITOXT - Mitochondrial Toxicity and Experimental Therapeutics Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/07 - 2014/08 Internship at the Microbiology of Extreme Environments Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2020/02 - 2020/07 Sterilaerogel - Green method to prepare sterilized biopolymers based aerogel
POCI-01-0145-FEDER-032625
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/05 - 2019/12 Healthy Aging
CENTRO-01-0145-FEDER-000012
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/09 - 2019/02 Hemoinduction: mechanisms underlying hemogenic induction in human fibroblasts
PTDC/BIM-MED/0075/2014
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023 - 2026 GAinPD: Validation of bacterial-derived anti-inflammatory mediators in gut-first PD.
SC01: CP
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Cure Parkinson's
Ongoing
2022 - 2025 Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic
PTDC/BIA-MIC/0122/2021 (249.975 ¿)
Administração Regional de Saúde do Centro IP, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024 The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020 (248.992 ¿)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024 STOPD - The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020 (248.992)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2023 O Eixo microbioma-miRNAs na Doença de Parkinson: implicações da resposta inflamatória mediada pela mitocôndria
EXPL/MED-NEU/1515/2021
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Candeias, Emanuel; Nunes-Costa, Daniela; Pereira-Santos, AR.; Magalhães, João Duarte; Melo-Marques, Inês; Guedes, Beatriz; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Neurotoxicity induced by the microbial metabolite ß-methylamino-L-alanine: pathways and mechanisms". In Natural Molecules in Neuroprotection and Neurotoxicity, 747-778. Elsevier, 2024.
    10.1016/b978-0-443-23763-8.00068-3
Conference paper
  1. Esteves, Ana Raquel; Munoz Pinto, Mario; Candeias, Emanuel; Silva, Diana F.; Magalhães, João; Pereira-Santos, AR.; Empadinhas, Nuno; Sandra Morais Cardoso. Corresponding author: Sandra Morais Cardoso. "The Parkinson Pandemic: a microbial toxin elicits Parkinson¿s disease-like neurodegeneration". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation, 2021.
Conference poster
  1. Pereira-Santos, AR.; Candeias, Emanuel; João Duarte Magalhães (951A-ADF2-AC6); Empadinhas, Nuno; Esteves, Ana Raquel; Sandra Morais Cardoso. "Neuronal control of microglia through the mitochondria". Paper presented in SINAL2024 - 11th meeting on signal transduction, 2024.
  2. Pereira-Santos, Ana Raquel; Candeias, Emanuel; Nunes-Costa, Daniela; Alarico, Susana; Tiago, Igor; Madeira, Nuno; Empadinhas, Nuno; Sandra Morais Cardoso. "2-HIT-SCZ: Unveiling the Gut-Immune-Brain axis in Schizophrenia". Paper presented in BEBDAY 2024: Not) Knowing What Comes Next: Tools for the research of Tomorrow, 2024.
  3. Pereira-Santos, AR.; Candeias, Emanuel; Esteves, Ana Raquel; João Duarte Magalhães; Nunes-Costa, Daniela; Tiago, Igor; Madeira, Nuno; Empadinhas, Nuno; Sandra Morais Cardoso. "THE PSYCHOBIOME: Unveiling the role of Gut-Immune-Brain axis in Schizophrenia". Paper presented in ESN-ISN Neurochemistry School 2023, 2023.
  4. Pereira-Santos, AR.; Candeias, Emanuel; Magalhães, João; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Neuronal control of microglia through the mitochondria". Paper presented in AD/PD 2023, 2023.
  5. Pereira-Santos, AR.; Candeias, Emanuel; Magalhães, João; Esteves, Ana Raquel; Nunes-Costa, Daniela; Tiago, Igor; Madeira, Nuno; Empadinhas, Nuno; Cardoso, Sandra Morais. "Unveiling the role of gut dysbiosis in Schizophrenia pathology". Paper presented in FENS-Hertie Winter School: Neuro-immune interactions in health and disease (Obergurgl, Austria), 2023.
  6. Pereira-Santos, AR.; Rita Alves; Carlos Filipe Pereira. "The Role of LSD1/CoREST complex during Hemogenic Reprogramming". Paper presented in Secretome Without Borders, Braga, Portugal, 2018.
Journal article
  1. Pereira-Santos, AR.; Candeias, Emanuel; Magalhães, J.D.; Empadinhas, Nuno; Esteves, A. Raquel; Cardoso, Sandra M.. Corresponding author: Cardoso, Sandra M.. "Neuronal control of microglia through the mitochondria". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 5 (2024): 167167. http://dx.doi.org/10.1016/j.bbadis.2024.167167.
    Published • 10.1016/j.bbadis.2024.167167
  2. Binder, Luisa B.; Rosa, Priscila B.; de Sousa, Bárbara M.; Chagas, Luana S.; Dubljevic, Olga; Martineau, Fanny Sandrine; Mottarlini, Francesca; et al. "Neuro-immune interactions in health and disease: Insights from FENS-Hertie 2022 Winter School". European Journal of Neuroscience (2024): http://dx.doi.org/10.1111/ejn.16262.
    Published • 10.1111/ejn.16262
  3. Munoz Pinto, Mario; Candeias, Emanuel; Esteves, Ana Raquel; Ana Branco Maranha Tiago 301C-9125-034E; Melo-Marques I; João Duarte Magalhães; Reis Carneiro, Diogo; et al. "Gut-first Parkinson’s disease is encoded by a transmissible gut dysbiome.". (2024):
    Submitted
  4. David Vicente-Zurdo; Noelia Rosales-Conrado; M. Eugenia León-González; Leonardo Brunetti; Luca Piemontese; A. Raquel Pereira-Santos; Sandra M. Cardoso; et al. "Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease". Biomedicines 10 7 (2022): 1510-1510. https://doi.org/10.3390/biomedicines10071510.
    10.3390/biomedicines10071510
  5. Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut (2021): gutjnl-2021. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    10.1136/gutjnl-2021-326023
  6. Gonçalves, Ana Mafalda; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra M.; Empadinhas, Nuno. "The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease". Antioxidants & Redox Signaling (2020): http://dx.doi.org/10.1089/ars.2019.7997.
    Published • 10.1089/ars.2019.7997
  7. Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al. "Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease". Molecules 25 4 (2020): 985. http://dx.doi.org/10.3390/molecules25040985.
    Published • 10.3390/molecules25040985
  8. Silva, Ana Marta; Barbosa, Inês A.; Seabra, Cátia; Beltrão, Nuno; Santos, Raquel; Vega-Naredo, Ignacio; Oliveira, Paulo J.; Cunha-Oliveira, Teresa. "Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity". Food and Chemical Toxicology 94 (2016): 148-158. http://dx.doi.org/10.1016/j.fct.2016.06.001.
    Published • 10.1016/j.fct.2016.06.001
Report
  1. Pereira-Santos, AR.. 2015. Final Graduation Project: Quantification of S-Adenosylmethionine, S-adenosylhomocysteine and Acetyl CoA in doxorubicin-treated H9c2 by HPLC.
Thesis / Dissertation
  1. Pereira-Santos, AR.. "The role of LSD1/CoREST complex during Hemogenic Reprogramming". Master, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/15 Invited Speaker at 6th Edition of BrainLoad: "Intestino, imunidade e cérebro: O que têm em comum?" 6th Edition of BrainLoad
Universidade de Aveiro

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/01 - 2022/01 "BEB Day 2022: The Overview Effect" esta edição do BEB Day 2022 pretende juntar um painel multidisciplinar de oradores nacionais e internacionais, com o objectivo de abordar os efeitos de problemas globais como a poluição e alterações climáticas na saúde, numa perspectiva dinâmica e interdisciplinar. (2022/01/18 - 2022/01/19)
Conference (Member of the Organising Committee)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/05/24 - 2024/05/25 Participation and poster presentation at SINAL2024 - 11th meeting on signal transduction
Congress
 SINAL2024 - 11th meeting on signal transduction
Universidade de Coimbra Faculdade de Medicina, Portugal
2024/05/15 - 2024/05/16 Participation and poster presentation in BEBDAY 2024: Not) Knowing What Comes Next: Tools for the research of Tomorrow
Congress
 BEBDAY 2024: Not) Knowing What Comes Next: Tools for the research of Tomorrow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/04 - 2024/04 Semana da Ciência e Tecnologia 2024.
2023/10/29 - 2023/11/03 ESN-ISN Neurochemistry School - Full Travel Grant
Workshop
 ESN-ISN Neurochemistry School
Algarve Biomedical Center Research Institute, Portugal
2023/03/28 - 2023/04/01 Participation and poster presentation AD/PD™ 2023 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (Gothenburg, Sweden)
Congress
2023/03/07 - 2023/03/08 Theorectical and Pratical Course FLOW CYTOMETRY AND CELL SORTING - From Basic Concepts to Artificial Intelligence applied to Data Analysis
Workshop
 FLOW CYTOMETRY AND CELL SORTING - From Basic Concepts to Artificial Intelligence applied to Data Analysis
Universidade de Coimbra, Portugal
2023/01/29 - 2023/02/04 Participation and poster presentation in FENS-Hertie Winter School: Neuro-immune interactions in health and disease (Obergurgl, Austria)
Congress
 FENS-Hertie Winter School: “Neuro-immune interactions in health and disease” (Obergurgl, Austria)
Federation of European Neuroscience Societies, Belgium
2023/01 - 2023/01 Semana da Ciência e Tecnologia 2023.
Other
 Semana da Ciência e Tecnologia 2022.
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/04/27 - 2022/04/27 Participation in "Seahorse XF Analyzers: AGILENT CELL ANALYSIS SEMINAR & WORKSHOP"
Workshop
 Seahorse XF Analyzers: AGILENT CELL ANALYSIS SEMINAR & WORKSHOP
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/03/05 - 2020/05/05 Selfie Science- Raquel Santos (Episode 22) "Selfie Science" challenges CNC researchers to explain their research work in simple language of 2 to 3 minutes. In each video, the researchers contextualize their work schematically, and explain a crucial technique for the work. In this episode, I had the opportunity to explain my work on gut-brain axis in Parkinson's disease in a simple and accessible way to the community. URL: https://www.facebook.com/CNC.UC/videos/627209668070805/
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/12/06 - 2018/12/07 Participation and poster presentation in the 1st International Symposium Secretome Without Borders, Braga 2018.
Symposium
 1st International Symposium Secretome Without Borders
Portuguese Society for Stem Cells and Cell Therapies, Portugal
2018/09/27 - 2018/09/28 Participation in the Drugs R&D PhD Symposium organized by 1st edition Drugs R&D PhD Programme students of Faculdade de Farmácia da Univesidade de Coimbra.
Symposium
 Drugs R&D PhD Symposium
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/06/19 - 2018/06/19 Participation in the course Protection of inventions in health sciences and life sciences: particularities and practical examples organized by Divisão de Inovação e Transferência do Saber da Universidade de Coimbra.
Workshop
 Protection of inventions in health sciences and life sciences: particularities and practical examples
Universidade de Coimbra, Portugal
2017/11/15 - 2017/11/15 Participation in the World Cord Blood Day 2017- Virtual Conference organized by Crioestaminal.
Conference
 World Cord Blood Day 2017- Virtual Conference
Crioestaminal, Portugal
2016/02/04 - 2016/02/04 Participation in the 2nd Meeting Heart Without Borders organized by Rede Nacional de Investigadores em Ciências Cardiovasculares.
Meeting
 2nd Meeting Heart Without Borders
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/06/16 - 2015/06/16 Participation in the course on integrated management of hospital residues, organized by the Ambimed.
Workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/12/17 - 2014/12/20 Participation in the XVIII Congress of the Portuguese Biochemical Society as a member.
Congress
 XVIII Congress of the Portuguese Biochemical Society
Sociedade Portuguesa de Bioquímica, Portugal
2014/10/31 - 2014/11/01 Participation in the conference Emerging Pathways for Young Scientists 2.0 including the virtual workshop of the American Society of Microbiology untitled Scientific Writing and Publishing and the Art of Science Communications.
Workshop
 Emerging Pathways for Young Scientists 2.0
Universidade de Coimbra, Portugal

Conference scientific committee

Conference name Conference host
2024/05/15 - Current Roundtable discussion at 6th Edition of BrainLoad entitle "Investigação Científica em Portugal: Desafios e Oportunidades" Universidade de Aveiro

Mentoring / Tutoring

Topic Student name
2023/04 - 2023/06 Supervision of Laboratory Rotation "The role of Gut Immunity in Schizophrenia pathogenesis" Soraia Faria
2023/03 - 2023/03 Supervision of Laboratory Rotation "Neuronal control of microglia through the mitochondria" Catarina Oliveira
2019/02/01 - 2019/02/28 Supervision of Laboratory Rotation "Improving hemogenic reprogramming efficiency" Camila Carola
2018/04/01 - 2018/04/30 Supervision of Laboratory Rotation "Elucidating Gata2 Domains involved in the interaction with Gfi1b during hemogenic reprogramming" Luís Oliveira
2018/01/02 - 2018/01/31 Supervision of Laboratory Rotation "Development of molecular tools to study the mitotic bookmarking of Gata2. Gfi1b and cFos, during reprogramming of fibroblasts to HSCs" Catarina Silva
Distinctions

Award

2024 PDBEB Student Best Scientific Publication Extraordinary Support: "Neuronal control of microglia through the mitochondria" (doi: 10.1016/j.bbadis.2024.167167).
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 PhD fellowship (2020.06543.BD)
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2020 Research Fellowship in the project "Sterilaerogel - Green method to prepare sterilized biopolymers based aerogel" (BIM-POCI-01-0145-FEDER-032625), Molecular Micobacteriology and Microbiome Lab
2019 Research Fellowship in the project “HEALTHYAGING 2020" (CENTRO-01-0145-FEDER-000012), Mitochondrial Signaling in Neurodegeneration Group
2018 Research Fellowship in the project “Mechanisms of hemogenic induction in human fibroblasts” (PTDC/BIM-MED/0075/2014), Cell Reprogramming and Developmental Hematopoiesis Lab