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Mónica Galocha completed her degree in Biology in 2015 at University of Lisbon, Faculty of Sciences. Concluded her MSc and PhD degrees in Biotechnology and Biosciences from Instituto Superior Técnico, University of Lisbon, in 2017 and 2023, respectively. Mónica Galocha has currently a Postdoctoral contract at Malaria Lab headed by Maria Mota, at Gulbenkian Institute for Molecular Medicine (GIMM). Published 14 papers in peer reviewed international journals and 2 book chapters. Contributed to the public databases PathoYeastract and YEASTRACT. Participated in 4 international scientific events. Mentored 3 MSc students and juried 1 MSc’s dissertation. Received 4 awards/honors. Participated as PhD Fellow in 1 project. Mónica Galocha works in the area of Biological Sciences with an emphasis on Cellular Biology, Infectious Diseases, and Genomics. Currently, her research at Mota Lab is focused on the biology and physiology of the malaria parasite, namely the mechanisms and molecular players of the high replication rate occurring during the parasite liver stage schizogony, which influences parasite genetic diversity and virulence.
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Identification

Personal identification

Full name
Mónica da Luz Galocha

Citation names

  • Galocha, Mónica

Author identifiers

Ciência ID
5610-C2F3-AE9F
ORCID iD
0000-0002-4090-7016
Google Scholar ID
BKMJhl8AAAAJ&hl

Email addresses

  • monica.galocha@gimm.pt (Professional)

Telephones

Telephone
  • 217999411 Ext.: 47343 (Professional)

Addresses

  • Gulbenkian Institute for Molecular Medicine (GIMM), Av. Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Spanish; Castilian Intermediate (B1) Beginner (A1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2024/11
Concluded
 FLxFlow Course – Principles and Applications of Flow Cytometry (Diploma de especialização)
Gulbenkian Institute for Molecular Medicine, Portugal
2024/07
Concluded
 Realização de procedimentos em animais (Pequenos Roedores) e de Prestação de cuidados aos animais (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2018/10 - 2023/02
Concluded
 Biotecnologia e Biociências (Doutoramento)
Major in Sem especialidade
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Unveiling new pathways of genomic evolution towards drug resistance in Candida glabrata" (THESIS/DISSERTATION)
 Pass with Distinction and Honour
2022/02
Concluded
 Radiological Protection and Safety level III (Diploma de especialização)
Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
2018
Concluded
 IELTS English Certificate (Diploma de especialização)
British Council Portugal, Portugal
 C1
2015/09 - 2017/11
Concluded
 Biotecnologia (Mestrado)
Major in Sem especialização
Universidade de Lisboa Instituto Superior Técnico, Portugal
"New players controlling multidrug resistance and biofilm formation in Candida glabrata: the important role of Rpn4" (THESIS/DISSERTATION)
 17
2011/09 - 2015/07
Concluded
 Biologia (Licenciatura)
Major in Biologia Evolutiva e do Desenvolvimento
Universidade de Lisboa Faculdade de Ciências, Portugal
 15
Affiliation

Others

Category
Host institution 		Employer
2024/02/01 - Current Postdoctoral contract at Biology & Physiology of Malaria Lab headed by Maria Mota, PhD Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2019/10 - 2020/03 Visiting Researcher Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Vlaams Instituut voor Biotechnologie VIB-KU Leuven Center for Microbiology, Belgium
2018/01 - 2018/09 Research Fellow for the Project Biodata.pt, “Portuguese Biological Data Network" BioData.pt, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
(...)
Projects

Grant

Designation Funders
2022/12/01 - 2023/01/31 Fighting candida infections throughsystems biology approaches: from navel targets to navel drugs
COVID/BD/153020/2022
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2022/11/30 Fighting candida infections throughsystems biology approaches: from navel targets to navel drugs
PD/BD/143027/2018
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/10/01 - 2022/09/30 Inibição da patogénese e construção de fábricas celulares: por desenvolvimento de modelos regulatórios-metabólicos mistos à escala do genoma em leveduras
PTDC/BII-BIO/28216/2017
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Viana, Romeu; Pais, Pedro; Cavalheiro, Mafalda; Galocha, Mónica; Teixeira, Miguel C.. "Host-Induced Stress Response in Human Pathogenic Fungi". In Encyclopedia of Mycology, 182-196. Elsevier, 2021.
    10.1016/b978-0-12-819990-9.00035-4
  2. Galocha, Mónica. "Genome-Wide Response to Drugs and Stress in the Pathogenic Yeast Candida glabrata.". In Progress in molecular and subcellular biology. 2019.
    Published • 10.1007/978-3-030-13035-0_7
Conference paper
  1. Viana, Romeu; Dias, Oscar; Bastos, José; Lagoa, Davide Rafael Santos; Galocha, Mónica; Rocha, I.; Teixeira, Miguel Cacho. "Genome-scale metabolic model of the human pathogen C. albicans: aiming the identification of promising new drug targets". 2019.
Conference poster
  1. Galocha, Mónica; Pais, Pedro; Viana, Romeu; Vieira Costa, Inês; Silva-Dias, A; Cavalheiro, Mafalda; Miranda, IM; et al. Corresponding author: Galocha, Mónica. "Unveiling new pathways of genomic evolution towards azole resistance in Candida glabrata". Paper presented in iBB Workshop, 2022.
  2. Vieira Costa, Inês; Pais, Pedro; Zolotareva, Maria; Cavalheiro, Mafalda; Galocha, Mónica; Cacho Teixeira, Miguel. "A functional genomics approach to follow the evolution of biofilm formation capacity in Candida glabrata clinical isolates". Paper presented in iBB Workshop, 2022.
  3. Vieira Costa, Inês; Pais, Pedro; Zolotareva, Maria; Cavalheiro, Mafalda; Galocha, Mónica; Viana, Romeu; Cacho Teixeira, Miguel. Corresponding author: Vieira Costa, Inês. "Unveiling the genomic basis for differential biofilm formation capacity in Candida glabrata clinical isolates". Paper presented in Microbiotec'21, 2021.
  4. Galocha, Mónica; Silva-Dias, Ana; Pedro pais; Cavalheiro, Mafalda; Miranda, Isabel M.; Chibana, Hiroji; Rodrigues, Acácio G.; Miguel C. Teixeira. Corresponding author: Miguel C. Teixeira. "Candida glabrata evolution towards posaconazole resistance irrespective of PDR1 GOF mutations". Paper presented in HFP2019 – Advanced Lecture Course in Molecular Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens, 2019.
  5. Pais, Pedro; Galocha, Mónica; Viana, Romeu; Cavalheiro, Mafalda; Pereira, Diana; Teixeira, Miguel C.. "Deciphering transcription regulation of antifungal drug resistance in the pathogenic yeast Candida glabrata". Paper presented in MICROBIOTEC, 2017.
    10.24264/icams-2018.i.11
Journal article
  1. Teixeira, Miguel Cacho; Viana, Romeu; Palma, Margarida; Oliveira, Jorge; Galocha, Mónica; Mota, Marta Neves; Couceiro, Diogo; et al. "YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis". Nucleic Acids Research 51 D1 (2022): D785-D791. http://dx.doi.org/10.1093/nar/gkac1041.
    10.1093/nar/gkac1041
  2. Pedro Pais; Mónica Galocha; Azusa Takahashi-Nakaguchi; Hiroji Chibana; Miguel C. Teixeira. "Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants". Microbial Cell (2022): https://doi.org/10.15698/mic2022.11.786.
    10.15698/mic2022.11.786
  3. Galocha, Mónica; Viana, Romeu; Pais, Pedro; Silva-Dias, Ana; Cavalheiro, Mafalda; Miranda, Isabel M.; Van Ende, Mieke; et al. "Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation". Communications Biology 5 1 (2022): http://dx.doi.org/10.1038/s42003-022-04087-0.
    10.1038/s42003-022-04087-0
  4. Pais, Pedro; Galocha, Mónica; Califórnia, Raquel; Viana, Romeu; Ola, Mihaela; Okamoto, Michiyo; Chibana, Hiroji; Butler, Geraldine; Teixeira, Miguel C.. "Characterization of the Candida glabrata Transcription Factor CgMar1: Role in Azole Susceptibility". Journal of Fungi 8 1 (2022): 61. http://dx.doi.org/10.3390/jof8010061.
    Open access • Published
  5. Cavalheiro, Mafalda; Romão, Daniela; Santos, Rui; Mil-Homens, Dalila; Pais, Pedro; Costa, Catarina; Galocha, Mónica; et al. "Role of CgTpo4 in Polyamine and Antimicrobial Peptide Resistance: Determining Virulence in Candida glabrata". International Journal of Molecular Sciences 22 3 (2021): 1376. http://dx.doi.org/10.3390/ijms22031376.
    10.3390/ijms22031376
  6. Galocha, Mónica; Costa, Inês Vieira; Teixeira, Miguel Cacho. "Carrier-Mediated Drug Uptake in Fungal Pathogens". Genes 11 11 (2020): 1324. http://dx.doi.org/10.3390/genes11111324.
    10.3390/genes11111324
  7. Monteiro, Pedro T.; Pedreira, Tiago; Galocha, Monica; Teixeira, Miguel C.; Chaouiya, Claudine. "Assessing regulatory features of the current transcriptional network of Saccharomyces cerevisiae". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-74043-7.
    10.1038/s41598-020-74043-7
  8. Viana, Romeu; Dias, Oscar; Lagoa, Davide; Galocha, Mónica; Rocha, Isabel; Teixeira, Miguel Cacho; Lagoa, Davide Rafael Santos. "Genome-Scale Metabolic Model of the Human Pathogen Candida albicans: A Promising Platform for Drug Target Prediction". Journal of Fungi 6 3 (2020): 171. http://dx.doi.org/10.3390/jof6030171.
    10.3390/jof6030171
  9. Pais, Pedro; Califórnia, Raquel; Galocha, Mónica; Viana, Romeu; Ola, Mihaela; Cavalheiro, Mafalda; Takahashi-Nakaguchi, Azusa; et al. "Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance Through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability". Antimicrobial Agents and Chemotherapy (2020): http://dx.doi.org/10.1128/aac.00554-20.
    10.1128/aac.00554-20
  10. Galocha, Mónica. "YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts.". Nucleic acids research (2020): https://europepmc.org/articles/PMC6943032.
    10.1093/nar/gkz859
  11. Galocha, Mónica. "Draft Genome Sequences of Three Clinical Isolates of the Pathogenic Yeast Candida glabrata.". Microbiology resource announcements (2019): https://europepmc.org/articles/PMC6715859.
    10.1128/MRA.00278-19
  12. Mónica Galocha; Pedro Pais; Mafalda Cavalheiro; Diana Pereira; Romeu Viana; Miguel C. Teixeira. "Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin". International Journal of Molecular Sciences 20 9 (2019): 2345-2345. https://doi.org/10.3390/ijms20092345.
    10.3390/ijms20092345
  13. Galocha, Mónica. "Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection.". Microbial cell (Graz, Austria) (2019): https://europepmc.org/articles/PMC6402363.
    10.15698/mic2019.03.670
  14. Mafalda Cavalheiro; Pedro Pais; Mónica Galocha; Miguel Teixeira. "Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!". Genes 9 7 (2018): 332-332. https://doi.org/10.3390/genes9070332.
    10.3390/genes9070332
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/04 Role of the Candida glabrata mediator complex subunit CgPgd1 in azole drug resistance and susceptibility: a transcriptomics approach 32nd ECCMID
European Congress of Clinical Microbiology & Infectious Diseases (Lisbon, Portugal)
2021/11 A new evolution pathway leading to azole resistance in Candida glabrata Microbiotec 2021
Online Event

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/03 Genome-based prospection of possible correlation between the hexose transporter family and antifungal drug resistance in Candida species
(Thesis) Main arguer
 Maria Beatriz Siborro Lopes (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/05/01 - 2019/07/01 Practical classes - Biochemistry and Molecular Biology Ciências de Engenharia - Engenharia Biológica (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal

Mentoring / Tutoring

Topic Student name
2022/09 - 2023/11 Contribution to the functional characterization of the C. glabrata hexose transporter family Veerle van Berkum (MSc)
2019/09 - 2021/05 Role of the Candida glabrata mediator complex subunit Pgd1 in azole drug resistance and susceptibility: a transcriptomics approach Inês Vieira Costa (MSc)
2019/01 - 2019/12 Identifying Pdr1-independent azole resistance mechanism on Candida Glabrata; based on directed evolution and genome sequencing Maria Teresa Beirão do Carmo Abreu (MSc)
Distinctions

Award

2022 Best PhD Work in Research and Infectious Diseases
Universidade de Lisboa, Portugal
2019 Best PhD poster
FEBS - Federation of the European Biochemical Societies, United Kingdom

Other distinction

2017 Quadro de Mérito
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Quadro de Mérito
Universidade de Lisboa Instituto Superior Técnico, Portugal