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Sandra Morais Cardoso is an Assistant Professor at Faculty of Medicine and the group leader of Gut-Brain Axis Group at CNC, University of Coimbra. Her most recent research focus on the role of the microbiome-mitochondria crosstalk in the activation of neuronal innate immunity and its impact in the development of neurodegenerative and neuropsychiatric diseases. She published over 111 papers (H index= 54; >14000 citations; WoS). Mentored 10 PhD and 20 MSc students and coordinated 13 and participated in 14 research grants. In recognition of her professional track and contributions in the field of Health research, she was awarded a Medal of Merit from the Ministry of Health in 2013. The research developed on the role of mitochondria in the etiology and progression of Parkinson's disease was distinguished with the Janssen Neurosciences Award in 2014, and also with the Mantero Belard Prize (2016) by Santa Casa da Misericórdia de Lisboa. In 2023 she received the Pfizer award to the best research paper.
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Identification

Personal identification

Full name
Sandra Morais Cardoso

Citation names

  • Cardoso SM
  • Sandra M Cardoso
  • Sandra Morais Cardoso

Author identifiers

Ciência ID
5613-FABA-04C5
ORCID iD
0000-0002-2199-0555

Email addresses

  • cardoso.sandra.m@gmail.com (Professional)
  • sicardoso@fmed.uc.pt (Professional)
  • smcardoso@cnc.uc.pt (Professional)

Telephones

Telephone
  • 239 Ext.: 820190 (Professional)

Addresses

  • CNC - Centro de Neurociências e Biologia Celular, Universidade de Coimbra. Rua Larga, Faculdade de Medicina, Pólo I, 1º andar., 3004-504, Coimbra, Coimbra, Portugal (Professional)
  • Faculdade de Medicina, Universidade de Coimbra, Polo III - Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-354 , Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2004
Concluded
 Cell Biology (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1998
Concluded
 Cell Biology (Mestrado)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1995
Concluded
 Biology (Licenciatura)
Major in Cell Biology
Universidade de Coimbra Departamento de Ciências da Terra, Portugal
Affiliation

Science

Category
Host institution 		Employer
2006 - Current Principal Investigator (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2012 - Current Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2022/01/01 - 2022/12/31 Study of TNF-mediated blood-brain barrier disruption during gut dysbiosis as consequence of SCFAs alterations
PMDF
Co-Principal Investigator (Co-PI)
Concluded
2018/01 - 2018/12 O papel dos metabolitos microbianos na doença de Parkinson
Provided by PTCRIS: 83206
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Concluded
2016/09 - 2017/08 AntiPDbiotics: The impairment of neuronal metabolism by gut microbiome effectors
FMUC-BST-2016-221
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
2014/01 - 2014/12 Validate tau acetylation as an AD biomarker
GAI-FMUC
Principal investigator
Concluded
2014/01 - 2014/12 Produção e comercialização global de compostos microbianos essenciais para investigação.
Mais Centro/CCDRC/QREN
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - 2009 O papel da disfunção mitocondrial na alteração do citoesqueleto: relevância para a Doença de Parkinson
GAI 07/08 FMUC
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
2008 - 2009 A associação entre a mitocôndria e o sistema ubiquitina/proteosoma no âmbito da doença de Parkinson.
GAI 15/08 FMUC
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
2005 - 2006 From mitochondrial dysfunction to protein aggregation in Parkinson’s disease
GAI 03/04 FMUC
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded

Contract

Designation Funders
2021 - Current STOPD - The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2026 GAin-PD: Validation of bacterial-derived anti-inflammatory mediators in gut-first PD
CP project code: SC01
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Cure Parkinson's
Ongoing
2022 - 2025 Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic
PTDC/BIA-MIC/0122/2021
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2023 Microbiome-miRNAs axis in Parkinson’s disease: involvement of mitochondrial mediated inflammatory response
EXPL/MED-NEU/1515/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/09 - 2021/08 The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative disorders.
FCT-C490959332-00082704/2018
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/09 - 2020/08 The toxinogenic gut microbiome in sporadic Parkinson’s Disease: a quest for new “antiPDbiotics”.
Provided by PTCRIS: 57310
Principal investigator
Santa Casa da Misericórdia de Lisboa
Ongoing
2018 - 2020 The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
Researcher
Ongoing
2017 - 2020 Healthy Aging 2020
CENTRO-01-0145-FEDER-000012
Researcher
Concluded
2013 - 2015 New strategies to manage brain diseases
QREN
Researcher
2010/02 - 2013/05 Mitochondrial-dependent impairment of intracellular trafficking in Parkinson's disease
Provided by PTCRIS: 102710
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/03 The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
Provided by PTCRIS: 103325
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2013 NEUROMED
SOE4/P1/E831
Researcher
Concluded
2009 - 2011 Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools.
PIC/IC/83206/2007
Researcher
Concluded
Outputs

Publications

Book
  1. Esteves, A.R.; Arduino, D.M.; Silva, D.F.F.; Martins Branco, D.; Oliveira, C.R.; Cardoso, S.M.; Cardoso SM. Mitochondrial metabolism in age-related neurodegenerative disorders: Alzheimer's and parkinson's revisited. Nova Science Publishers. 2011.
Book chapter
  1. Cardoso SM. Corresponding author: Cardoso SM. "Neurotoxicity induced by ß-N-methylamino-L-alanine (BMAA)". In Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier Inc. Publisher., 2023.
    Published
  2. Sandra Morais Cardoso. "The Role of Autophagy in Parkinson’s disease Etiopathogenesis". In The Neuroscience of Parkinson's Disease. 2020.
  3. Esteves, A. Raquel; Silva, Diana F.; Santos, Daniel; Candeias, Emanuel; Filipe, Filipa; Cardoso, Sandra M.. "Mitochondria at the Base of Neuronal Innate Immunity in Alzheimer’s and Parkinson’s Diseases". In Mitochondrial Diseases. InTech, 2018.
    10.5772/intechopen.72612
  4. Esteves, Ana Raquel; Silva, Diana Filipa; Gonçalves-Fernandes, Maria; Gomes, Rui; Cardoso, Sandra Morais. "Regulation of Autophagy in Parkinson’s Disease". In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 197-212. Elsevier, 2016.
    10.1016/b978-0-12-802937-4.00011-9
  5. Sandra Morais Cardoso. "Mitochondrial Therapeutic approaches in Parkinson's Disease". In Mitochondrial mechanisms of degeneration and repair in Parkinson’s disease. 2016.
  6. Arduíno DM; Esteves AR; Swerdlow RH; Cardoso SM. "A cybrid cell model for the assessment of the link between mitochondrial deficits and sporadic Parkinson's disease.". 2015.
    10.1007/978-1-4939-2288-8_31
  7. Sandra Morais Cardoso. "Autophagy, the “master” regulator of cellular quality control: what happens when autophagy fails?". In Autophagy - A Double-Edged Sword - Cell Survival or Death?. 2013.
  8. Cardoso SM; Sandra Morais Cardoso; Silva DF; Silva, D.F.; Selfridge, J.E.; Lu, J.; E, L.; Cardoso, S.M.; Swerdlow, R.H.. "Mitochondrial abnormalities in Alzheimer's disease: Possible targets for therapeutic intervention.". In Current State of Alzheimer’s Disease Research and Therapeutics. Elsevier, 2012.
    Published • 10.1016/B978-0-12-394816-8.00003-9
  9. Cardoso SM; Arduino, D.M.; Esteves, A.R.; Martins-Branco, D.; Santos, D.; Silva, D.F.F.; Cardoso, S.M.. "Therapeutic Intervention at Cellular Clearance Mechanisms: significance to Parkinson’s disease.". In PD, Diagnosis Treatment and Prognosis. Nova Science Publishers, 2011.
  10. Sandra Morais Cardoso. "The crucial role of mitochondria in Parkinson’s disease". In Recent Research Developments in Neuroscience. 2009.
  11. Sandra Morais Cardoso. "Fisiopatologia da doença de Alzheimer". In Psiquiatria Clínica. 2006.
  12. Cardoso SM; Rego, A.C.; Cardoso, S.M.; Oliveira, C.R.. "Molecular pathways of mitochondrial dysfunction in neurodegeneration: the paradigms of Parkinson’s and Huntington’s diseases". In Interaction Between Neurons and Glia in Aging and Disease. Springer New York, 2006.
    Published • 10.1007/978-0-387-70830-0_9
Journal article
  1. Cardoso, Sandra M.; Melo-Marques I; Empadinhas, Nuno. Corresponding author: Cardoso, Sandra M.. "Bacterial extracellular vesicles at the interface of gut microbiota and immunity". Gut Microbes 16 (2024):
    In press
  2. Sandra M Cardoso. Corresponding author: Sandra M Cardoso. "Neuronal control of microglia through the mitochondria". BBA-Molecular Basis of Disease (2024):
    Accepted
  3. João Duarte Magalhães; Emanuel Candeias; Inês Melo-Marques; António E. Abreu; Ana Raquel Pereira-Santos; Ana Raquel Esteves; Sandra Morais Cardoso; Nuno Empadinhas. "Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson’s Disease". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25063423.
    10.3390/ijms25063423
  4. Leo Bon; Angelika Banas; Inês Dias; Inês Melo-Marques; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16020281.
    10.3390/pharmaceutics16020281
  5. Costa, Helena Nunes; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Parkinson's Disease: A Multisystem Disorder". Neuroscience Bulletin 39 1 (2023): 113-124. http://dx.doi.org/10.1007/s12264-022-00934-6.
    Published • 10.1007/s12264-022-00934-6
  6. Daniela Marinho; Ildete Luísa Ferreira; Ricardo Lorenzoni; Sandra M. Cardoso; Isabel Santana; A. Cristina Rego. "Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease". Aging Cell (2023): https://doi.org/10.1111/acel.13895.
    10.1111/acel.13895
  7. A. Raquel Esteves; Diana F. Silva; Diogo Banha; Emanuel Candeias; Beatriz Guedes; Sandra M. Cardoso. "LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease". Redox Biology (2023): https://doi.org/10.1016/j.redox.2023.102714.
    10.1016/j.redox.2023.102714
  8. João D. Magalhães; Emanuel Candeias; Inês Melo-Marques; Diana F. Silva; A. Raquel Esteves; Nuno Empadinhas; Sandra Morais Cardoso. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson’s disease". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04819-3.
    10.1007/s00018-023-04819-3
  9. David Vicente-Zurdo; Leonardo Brunetti; Luca Piemontese; Beatriz Guedes; Sandra M. Cardoso; Daniel Chavarria; Fernanda Borges; et al. "Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24098312.
    10.3390/ijms24098312
  10. Beatriz F. S. Guedes; Sandra Morais Cardoso; Ana Raquel Esteves. "The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson’s Disease". Biomedicines (2023): https://doi.org/10.3390/biomedicines11051349.
    10.3390/biomedicines11051349
  11. João D. Magalhães; Ana Raquel Esteves; Emanuel Candeias; Diana F. Silva; Nuno Empadinhas; Sandra Morais Cardoso; João Duarte Magalhães, A Raquel Esteves, Emanuel Candeias, Diana F Silva, Nuno Empadinhas, Sandra Morais Cardoso. "The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24054339.
    Accepted • 10.3390/ijms24054339
  12. João D. Magalhães; Sandra Morais Cardoso. "Mitochondrial signaling on innate immunity activation in Parkinson disease". Current Opinion in Neurobiology (2023): https://doi.org/10.1016/j.conb.2022.102664.
    10.1016/j.conb.2022.102664
  13. Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut 72 1 (2023): 73-89. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    Open access • Published • 10.1136/gutjnl-2021-326023
  14. Silva, Diana Filipa; Empadinhas, Nuno; Cardoso, Sandra Morais; Esteves, Ana Raquel. "Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation". Antioxidants 11 11 (2022): 2141. http://dx.doi.org/10.3390/antiox11112141.
    Published • 10.3390/antiox11112141
  15. David Vicente-Zurdo; Noelia Rosales-Conrado; M. Eugenia León-González; Leonardo Brunetti; Luca Piemontese; A. Raquel Pereira-Santos; Sandra M. Cardoso; et al. "Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease". Biomedicines (2022): https://doi.org/10.3390/biomedicines10071510.
    10.3390/biomedicines10071510
  16. João Duarte Magalhães; Lígia Fão; Rita Vilaça; Sandra Morais Cardoso; Ana Cristina Rego. "Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions". Biomedicines (2021): https://doi.org/10.3390/biomedicines9111625.
    10.3390/biomedicines9111625
  17. Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso. "The neuromicrobiology of Parkinson’s disease: A unifying theory". Ageing Research Reviews 70 (2021): 101396-101396. https://doi.org/10.1016/j.arr.2021.101396.
    Published • 10.1016/j.arr.2021.101396
  18. Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F.. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease". Biomedicines 9 8 (2021): 881. http://dx.doi.org/10.3390/biomedicines9080881.
    10.3390/biomedicines9080881
  19. Gonçalves, Ana Mafalda; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra M.; Empadinhas, Nuno. "The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease". Antioxidants & Redox Signaling 34 8 (2021): 694-711. http://dx.doi.org/10.1089/ars.2019.7997.
    Published • 10.1089/ars.2019.7997
  20. Cardoso SM. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy (2021): https://doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  21. Cardoso SM. "Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents.". Biomolecules (2021): https://europepmc.org/articles/PMC7830597.
    10.3390/biom11010111
  22. Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease". Journal of Enzyme Inhibition and Medicinal Chemistry 35 1 (2020): 211-226. http://dx.doi.org/10.1080/14756366.2019.1689237.
    10.1080/14756366.2019.1689237
  23. Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M.. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-02004-y.
    Open access • Published • 10.1186/s12974-020-02004-y
  24. Esteves, A. R.; Cardoso, S. M.. "Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-70174-z.
    10.1038/s41598-020-70174-z
  25. Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al. "Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease". Molecules 25 4 (2020): 985. http://dx.doi.org/10.3390/molecules25040985.
    10.3390/molecules25040985
  26. Nunes-Costa, Daniela; Magalhães, João Duarte; G-Fernandes, Maria; Cardoso, Sandra Morais; Empadinhas, Nuno. "Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration". Frontiers in Aging Neuroscience 12 (2020): http://dx.doi.org/10.3389/fnagi.2020.00026.
    10.3389/fnagi.2020.00026
  27. Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia. "Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization". Journal of Inorganic Biochemistry (2020): 111039. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039.
    10.1016/j.jinorgbio.2020.111039
  28. Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa. "Is Alzheimer’s disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): 100966. http://dx.doi.org/10.1016/j.arr.2019.100966.
    10.1016/j.arr.2019.100966
  29. A. Raquel Esteves; Filipa Filipe; João D. Magalhães; Diana F. Silva; Sandra M. Cardoso. "The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease". Molecular Neurobiology 56 8 (2019): 5654-5670. https://doi.org/10.1007/s12035-019-1483-8.
    10.1007/s12035-019-1483-8
  30. Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M.. "Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2019): 2008-2023. http://dx.doi.org/10.1016/j.bbadis.2018.11.014.
    10.1016/j.bbadis.2018.11.014
  31. Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos. "New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease". Molecules (2019): http://www.mdpi.com/1420-3049/24/3/587.
    10.3390/molecules24030587
  32. Melo, Karla P.; Silva, Carolliny M.; Almeida, Michael F.; Chaves, Rodrigo S.; Marcourakis, Tania; Cardoso, Sandra M.; Demasi, Marilene; Netto, Luis E. S.; Ferrari, Merari F. R.. "Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols". Neurotoxicity Research 35 2 (2018): 410-420. http://dx.doi.org/10.1007/s12640-018-9966-3.
    10.1007/s12640-018-9966-3
  33. Cardoso, Sandra M.; Empadinhas, Nuno. "The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00471.
    10.3389/fphys.2018.00471
  34. Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease". European Journal of Medicinal Chemistry 148 (2018): 255-267. http://dx.doi.org/10.1016/j.ejmech.2018.02.023.
    10.1016/j.ejmech.2018.02.023
  35. Hiremathad A; Chand K; Tolayan L; Rajeshwari; Keri RS; Esteves AR; Cardoso SM; Chaves S; Santos MA. "Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.". Journal of inorganic biochemistry (2018): http://europepmc.org/abstract/med/29182921.
    10.1016/j.jinorgbio.2017.11.015
  36. "Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.". Molecular neurobiology (2018): http://europepmc.org/abstract/med/28168426.
    10.1007/s12035-017-0420-y
  37. Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates". Journal of Enzyme Inhibition and Medicinal Chemistry 33 1 (2018): 1212-1224. https://doi.org/10.1080/14756366.2018.1491564.
    10.1080/14756366.2018.1491564
  38. Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug". Metallomics 10 10 (2018): 1460-1475. https://doi.org/10.1039/C8MT00143J.
    10.1039/C8MT00143J
  39. Almeida MF; Silva CM; Chaves RS; Lima NCR; Almeida RS; Melo KP; Demasi M; et al. "Effects of mild running on substantia nigra during early neurodegeneration.". Journal of sports sciences (2017): http://europepmc.org/abstract/med/28895489.
    10.1080/02640414.2017.1378494
  40. Cardoso SM. "Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.". (2017): http://europepmc.org/abstract/med/27311773.
  41. Esteves AR; Cardoso SM. "LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.". (2016): http://europepmc.org/abstract/med/26740081.
  42. Keri RS; Quintanova C; Chaves S; Silva DF; Cardoso SM; Santos MA. "New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.". (2016): http://europepmc.org/abstract/med/26256122.
    10.1111/cbdd.12633
  43. Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).". (2016): http://europepmc.org/abstract/med/26799652.
    10.1080/15548627.2015.1100356
  44. Sandra Morais Cardoso. "Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer´s drug candidates". RSC Advances (2016): https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03455a#!divCitation.
    Published
  45. Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM. "The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.". (2015): http://europepmc.org/abstract/med/25394383.
    10.1007/s12035-014-8980-6
  46. Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM. "The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.". (2015): http://europepmc.org/abstract/med/25218511.
    10.1007/s12035-014-8893-4
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  50. Sandra Morais Cardoso. "Design, Synthesis and Bioevaluation of Tacrine Hybrids with Cinnamate and Cinnamylideneacetate Derivatives as Potential Anti-Alzheimer Drug Candidates". Medicinal Chemical Communications (2015): https://pubs.rsc.org/en/content/articlelanding/2015/MD/c5md00236b#!divAbstract.
    Published
  51. Esteves, A.R.; Gozes, I.; Cardoso, S.M.. "The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 1 (2014): 7-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.10.003
  52. Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F.. "Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells". Molecular Neurobiology (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS.
    10.1007/s12035-014-8740-7
  53. Esteves, A.R.; Swerdlow, R.H.; Cardoso, S.M.. "LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis". Experimental Neurology 261 (2014): 206-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905511765&partnerID=MN8TOARS.
    10.1016/j.expneurol.2014.05.025
  54. Fonseca, A.C.; Oliveira, C.R.; Pereira, C.F.; Cardoso, S.M.. "Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells". Biochimica et Biophysica Acta - Molecular Cell Research 1843 6 (2014): 1150-1161. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896111540&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2014.02.016
  55. Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al. "The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 9 (2014): 1444-1453. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.05.003
  56. Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.. "Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease". Autophagy 9 1 (2013): 112-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS.
    10.4161/auto.22443
  57. Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M.. "Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease". Current Alzheimer Research 10 2 (2013): 180-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS.
    10.2174/1567205011310020008
  58. Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A.. "Multifunctional iron-chelators with protective roles against neurodegenerative diseases". Dalton Transactions 42 17 (2013): 6058-6073. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS.
    10.1039/c3dt50406a
  59. Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A.. "Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease". Bioorganic and Medicinal Chemistry 21 15 (2013): 4559-4569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.05.028
  60. Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F.. "Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 12 (2013): 2191-2203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS.
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  61. Silva, D.F.; Selfridge, J.E.; Lu, J.; Lezi, E.; Roy, N.; Hutfles, L.; Burns, J.M.; et al. "Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines". Human Molecular Genetics 22 19 (2013): 3931-3946. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888799219&partnerID=MN8TOARS.
    10.1093/hmg/ddt247
  62. Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic". Human Molecular Genetics 21 21 (2012): 4680-4702. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS.
    10.1093/hmg/dds309
  63. Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M.. "Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?". Experimental Neurology 238 2 (2012): 89-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS.
    10.1016/j.expneurol.2012.08.008
  64. Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a". Neurobiology of Disease 45 1 (2012): 206-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS.
    10.1016/j.nbd.2011.08.005
  65. Cardoso, S.M.; Esteves, A.R.; Arduno, D.M.. "Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease". Neurodegenerative Diseases 10 1-4 (2012): 38-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS.
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  66. Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy". Autophagy 8 4 (2012): 445-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS.
    10.4161/auto.19496
  67. Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2011.04.011
  68. Santos, D.; Cardoso, S.M.. "Mitochondrial dynamics and neuronal fate in Parkinson's disease". Mitochondrion 12 4 (2012): 428-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861695750&partnerID=MN8TOARS.
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  69. Cardoso, S.M.. "The mitochondrial cascade hypothesis for parkinson's disease". Current Pharmaceutical Design 17 31 (2011): 3390-3397. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS.
    10.2174/138161211798072508
  70. Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M.. "Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases". Current Pharmaceutical Design 17 31 (2011): 3446-3459. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS.
    10.2174/138161211798072481
  71. Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R.. "Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD". Parkinson's Disease (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS.
    10.4061/2011/693761
  72. Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al. "SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization". Cancer Cell 19 3 (2011): 416-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS.
    10.1016/j.ccr.2011.02.014
  73. Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.. "Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty". Parkinson's Disease (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS.
    10.4061/2011/767230
  74. Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease". Current Alzheimer Research 8 5 (2011): 563-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS.
    10.2174/156720511796391872
  75. Šebestík, J.; Marques, S.M.; Falé, P.L.; Santos, S.; Arduíno, D.M.; Cardoso, S.M.; Oliveira, C.R.; Serralheiro, M.L.M.; Santos, M.A.. "Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors". Journal of Enzyme Inhibition and Medicinal Chemistry 26 4 (2011): 485-497. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959882783&partnerID=MN8TOARS.
    10.3109/14756366.2010.529806
  76. Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M.. "Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway". Journal of Alzheimer's Disease 26 3 (2011): 565-581. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS.
    10.3233/JAD-2011-110423
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  78. Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease". CNS and Neurological Disorders - Drug Targets 9 1 (2010): 105-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS.
  79. Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS.
    10.3233/JAD-2010-091369
  80. Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al. "Polymorphic variation in cytochrome oxidase subunit genes". Journal of Alzheimer's Disease 21 1 (2010): 141-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS.
    10.3233/JAD-2010-100123
  81. Branco, D.M.; Arduino, D.M.; Raquel Esteves, A.; Silva, D.F.F.; Cardoso, S.M.; Oliveira, C.R.. "Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis". Frontiers in Aging Neuroscience 2 MAY (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350452&partnerID=MN8TOARS.
    10.3389/fnagi.2010.00017
  82. Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology". Neurobiology of Disease 37 3 (2010): 723-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS.
    10.1016/j.nbd.2009.12.011
  83. Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al. "Mitochondrial-dependent apoptosis in Huntington's disease human cybrids". Experimental Neurology 222 2 (2010): 243-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS.
    10.1016/j.expneurol.2010.01.002
  84. Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al. "Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer". Journal of Neurochemistry 113 3 (2010): 674-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.06631.x
  85. Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R.. "Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease". Experimental Neurology 223 2 (2010): 294-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS.
    10.1016/j.expneurol.2009.06.008
  86. Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids". Antioxidants and Redox Signaling 11 3 (2009): 439-448. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS.
    10.1089/ars.2008.2247
  87. Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R.. "Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease". Neurochemistry International 55 5 (2009): 341-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS.
    10.1016/j.neuint.2009.04.004
  88. Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R.. "ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells". BMB Reports 42 11 (2009): 719-724. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS.
  89. Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R.. "Mitochondria as a therapeutic target in Alzheimer's disease and diabetes". CNS and Neurological Disorders - Drug Targets 8 6 (2009): 492-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS.
    10.2174/187152709789824651
  90. Esteves, A.R.F.; Domingues, A.F.; Ferreira, I.L.; Januário, C.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background". Mitochondrion 8 3 (2008): 219-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449100897&partnerID=MN8TOARS.
    10.1016/j.mito.2008.03.004
  91. Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease". Free Radical Biology and Medicine 45 6 (2008): 820-825. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2008.06.007
  92. Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.05048.x
  93. Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells". Neurotoxicity Research 13 1 (2008): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS.
    10.1007/BF03033365
  94. Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A.. "New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs". Frontiers in Bioscience 13 17 (2008): 6763-6774. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS.
  95. Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.. "The key role of mitochondria in Alzheimer's disease". Journal of Alzheimer's Disease 9 2 (2006): 101-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS.
  96. Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R.. "Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine". Brain Research 1089 1 (2006): 44-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS.
    10.1016/j.brainres.2006.03.061
  97. Cardoso, S.M.; Oliveira, C.R.. "The role of calcineurin in amyloid-ß-peptides-mediated cell death". Brain Research 1050 1-2 (2005): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544459062&partnerID=MN8TOARS.
    10.1016/j.brainres.2005.04.078
  98. Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.; Cardoso, S.; Moreira, P.; Oliveira, C.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS.
    10.2174/1568007054546072
  99. Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.; Moreira, P.; Cardoso, S.; Oliveira, C.. "Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 383-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS.
    10.2174/1568007054546117
  100. Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R.. "Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity". Neurotoxicity Research 7 4 (2005): 273-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS.
    10.1007/BF03033885
  101. Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R.. "Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aß toxicity". Journal of Neurochemistry 89 6 (2004): 1417-1426. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042513691&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.02438.x
  102. Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R.. "Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells". Neurochemistry International 45 5 (2004): 693-698. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS.
    10.1016/j.neuint.2004.03.003
  103. Cardoso, S.M.; Proença, M.T.; Santos, S.; Santana, I.; Oliveira, C.R.. "Cytochrome c oxidase is decreased in Alzheimer's disease platelets". Neurobiology of Aging 25 1 (2004): 105-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348111546&partnerID=MN8TOARS.
    10.1016/S0197-4580(03)00033-2
  104. Pereira, Cláudia; Ferreiro, Elisabete; Cardoso, Sandra Morais; de Oliveira, Catarina Resende; Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.. "Cell Degeneration Induced by Amyloid-ß Peptides: Implications for Alzheimer's Disease". Journal of Molecular Neuroscience 23 1-2 (2004): 097-104. http://dx.doi.org/10.1385/jmn:23:1-2:097.
    10.1385/jmn:23:1-2:097
  105. Cardoso, S.M.; Oliveira, C.R.. "Glutathione cycle impairment mediates Aß-induced cell toxicity". Free Radical Research 37 3 (2003): 241-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361527&partnerID=MN8TOARS.
    10.1080/1071576021000041023
  106. Cardoso, S.M.; Oliveira, C.R.. "Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid ß peptides". Free Radical Research 37 9 (2003): 967-973. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141838915&partnerID=MN8TOARS.
    10.1080/10715760310001595757
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  109. Cardoso, S.M.; Pereira, C.; Oliveira, C.R.. "Mitochondrial function is differentially affected upon oxidative stress". Free Radical Biology and Medicine 26 1-2 (1999): 3-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS.
    10.1016/S0891-5849(98)00205-6
  110. Cardoso, S.M.; Pereira, C.; Oliveira, C.R.. "The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes". Biochemical and Biophysical Research Communications 246 3 (1998): 703-710. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS.
    10.1006/bbrc.1998.8563
  111. Cardoso SM. "Contribuição para o estudo do metabolismo da amiodarona: variação da concentração do iodo em diferentes orgãos dos ratinhos, após administração intraperitonial do fármaco.". Coimbra Médica 15 (1994):
Magazine article
  1. Cardoso SM. "Avanços Na Investigação Sobre A Doença De Parkinson: Onde Estamos?", Cidade Solidária, 2020
  2. Cardoso SM. "O papel do eixo microbioma-intestino-cérebro em doenças neurodegenerativas.", Cidade Solidária, 2017
Thesis / Dissertation
  1. Cardoso SM. "Molecular mechanisms of cell death in Alzheimer’s disease: The role of mitochondria". PhD, Universidade de Coimbra, 2004.
  2. Cardoso SM. "O efeito do stress oxidativo na função mitochondrial: um mecanismo explicativo para a acção de radicais livres na lesão cerebral". Master, Universidade de Coimbra, 1998.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024 The microbiome's impact on the development of neurodegenerative diseases 15th Symposium on Bioengineering
2024 O eixo intestino-cérebro e as doenças neurodegenerativas e neuropsiquiátricas IV Oporto Biomedical Summit
2023 Evidence of Host–Microbiome Interactions triggering “Gut-first” Parkinson’s disease 1 st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets
2023 The gut-immune-brain axis in PD MAC - Mitochondria in Aging, Cancer and Cell Death
2022/05 Footprints of a microbial toxin from the gut microbiome to the midbrain mitochondria Ciência 2022
2022/05 Gut microbiome-midbrain mitochondria axis in gut-first PD Annual Meeting of the European Society of Clinical Investigation
2022 Does Parkinson's disease start in the gut 5th PhDay Instituto de Investigação e Inovação em Saúde
2022 The key role of mitochondria in gut-first PD MITOtalks
2021/10 Microbioma intestinal e as Doenças Neurológicas Congresso Nacional de Neurologia
2021 Mitochondria as a target of the gut-brain hypothesis for sParkinson's disease FENS Regional Meeting
2019/12/21 Parkinson’s disease: a symptom of latent infection? CIBB meeting
(Portugal)
2019/11 Relação entre microbioma e alfa-sinucleinopatias. Congresso de Neurologia. Congresso de Neurologia
(Portugal)
2019/05 The gut hypothesis for Alzheimer´s disease: bacterial metabolites cause bioenergetic failure and activation of innate immunity in cortical neurons 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Portugal)
2019 O Papel do Eixo Intestino-Cérebro na Doença de Parkinson Conferência SANTA CASA Neurociências "Um olhar no futuro" - Longevidade e Doenças Neurodegenerativas
(Portugal)
2018 The role of Mitochondria in neuronal innate immunity activation: Relevance for Parkinson´s disease Annual Meeting of the European Society of Clinical Investigation
(Spain)
2018 The hidden microbiome in Parkinson’s disease NeuroTalk
(Thailand)
2018 E se a doença de parkinson tiver origem num desequilibrio do microbioma intestinal? Jornadas de Biologia Aplicada, Edição XIX
(Portugal)
2017 Mitocôndria, no caminho das doenças neurodegenerativas Discursos do cérebro: Revelações das neurociências.
Culturgest, Fundação da Caixa Geral Depósitos (Portugal)
2017 Mitochondrial Metabolism Regulates Microtubule Acetylome: Impact for Parkinson’s Disease 2nd Meeting on Biomedical Research
(Portugal)
2017 When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease. Annual Meeting of the European Society of Clinical Investigation
(Italy)
2016 New insights into the role of mitochondria in age-related neurodegenerative diseases. FEBS Meeting
(Turkey)
2015 Mitochondria – the key to neurodegeneration in PD EMBO workshop on Mitochondrial DNA and Neurodegeneration
EMBO (Spain)
2015 Mitochondria: in the road to neurodegeneration in sporadic Azheimer´s disease Symposium on Molecular Neurodegeneration
(Germany)
2014 A doença de Parkinson: Causas e Terapias Universidade do Algarve
(Portugal)
2014 Parkinson's disease: where do we stand? VIII Congresso Científico do NEF/AAC- Cérebro e (dis)funções
(Portugal)
2014 Mitochondria: the upstream driver of neurodegeneration in sporadic AD Grupo de Envelhecimento Cerebral e Demência (GEECD)
(Portugal)
2014 Identificação de um novo alvo terapêutico para a doença de Parkinson Forum de Neurologia
(Portugal)
2014 Mitochondria: the upstream driver of neurodegeneration in sporadic PD 2nd Annual Meeting of Coimbra Health School
(Portugal)
2014 Identificação de um novo alvo terapêutico para a doença de Parkinson Semana da Ciência e Tecnologia from University of Évora
2014 Bridging Tau and Amyloid-ß pathologies in sporadic Alzheimer´s disease: mitochondria under the spotlight . 2th International Conference on Alzheimer disease & Dementia,
(Portugal)
2014 Mitochondrial down-regulation of tubulin acetylation-dependent intracellular trafficking by SIRT2 impairs macroautophagy in Parkinson’s disease International Meeting on Mitochondrial Pathology, Euromit
(Finland)
2014 Mitochondria: the unifying entity from amyloid-ß and Tau pathology to neurodegeneration in sporadic Alzheimer´s disease . International Meeting on Mitochondrial Pathology, Euromit
(Finland)
2013 Mitochondrial metabolic control of microtubule dynamics impairs quality control autophagy IPATIMUP Seminars
(Portugal)
2013 Mitochondria: the upstream trigger of neurodegeneration in sporadic AD IBRO- symposium: Current Aspects of Pathophysiology of Alzheimer´s disease: what do we miss?
(Portugal)
2013 Mitochondrial involvement in autophagic dysfunction: a way to Parkinson’s disease Neurasmus workshop
(Portugal)
2013 Mitochondria drive autophagy pathology via microtubule disassembly in PD 1st reSEARCH Coimbra
(Portugal)
2013 Mitochondrial dysfunction dependent microtubule depolarization drives autophagic-lysosomal pathway impairment in MCI and AD cybrids XIII Reunião da Sociedade Portuguesa de Neurociências,
(Portugal)
2013 LRRK2 as a player on mitochondrial and microtubule dynamics impairment in sporadic PD XIII Reunião da Sociedade Portuguesa de Neurociências,
(Portugal)
2013 Bridging Alzheimer and Parkinson Diseases: Mitochondria the Common Upstream Driver AD/PD Meeting
(Italy)
2012 Mitochondria, Protein Homeostasis and Microtubule Networks in Parkinson’s Disease: When the Tracks Get Patchy Targeting Mitochondria
(Germany)
2012 Molecular and Cellular Pathways in Parkinson´s disease Universidade do Algarve
(Portugal)
2012 Ubiquitin Proteasome System in Parkinson's Disease:a keeper or a witness? ISCOMS
(Netherlands)
2012 Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells 26ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2011 Mitochondria breathe for autophagy: implications for Parkinson’s disease Lisbon Area Neurosciences Meetings
(Portugal)
2011 O Envelhecimento: alterações anatomo-fisiológicas Jornadas de Fisioterapia de Coimbra. ESTeSC
(Portugal)
2011 Sirt2 deacetylase activity controls the autophagy-lysosomal system by modulating the acetylation dynamics of tubulin cytoskeleton Targeting Mitochondria
(Germany)
2011 Synergistic roles of the proteasome and mitochondria in alpha-synuclein oligomerization: implications in Parkinson’s disease 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2011 Abnormal mitochondrial morphology and structure by impaired mitochondrial fission/fusion balance in a Parkinson’s disease cell model. 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2011 Acetylated Microtubules are required for an efficient autophagy progression: implications for Parkinson’s disease 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2011 NAM and NAP rescues alpha-synuclein oligomers mediated toxicity in Parkinson’s disease cybrids via a mechanism involving Microtubules stabilization and Sirtuins 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2011 Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in parkinson’s disease AD/PD Meeting
(Spain)
2010 Mitochondria: the common upstream driver of Abeta and Tau pathology in Alzheimer´s disease Eisai Meeting
(United Kingdom)
2010 Investigação na Doença de Parkinson Doenças Neurodegenerativas – Conhecer para Conviver
(Portugal)
2010 O controlo do metabolismo mitocondrial em doenças neurodegenerativas Núcleo de Estudantes de Engenharia Biomédica
(Portugal)
2010 Cérebro à prova de Envelhecimento CNC meeting
(Portugal)
2010 Mitochondrial dysfunction-mediated autophagy impairment: relevance to Alzhimer´s disease 24ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2009 Mitochondrial dysfunction induce proteasomal impairment in ndufa knockdown cells Yes Meeting
(Portugal)
2009 Mitochondrial control of the autophagic-lysosomal pathway. 23ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
(Portugal)
2009 À procura de um mundo melhor Museu da Ciência
(Portugal)
2008 O Cérebro e o envelhecimento Fórum Regional de Saúde do Algarve
(Portugal)
2008 O Cérebro e a Sociedade Museu da Ciência
(Portugal)
2008 Mitochondrial dysfunction and post-translational modifications of alpha-synuclein FENS Meeting
2008 Calcium induces coupling of endoplasmic reticulum stress response with mitochondria to initiate cell death signaling in Parkinson’s disease 22ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2008 Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids 22ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2008 The role of zinc on amyloid beta mediated toxicity 9th International symposium on Metal Ions in Biology and Medicine
(Portugal)
2007 Mitochondrial dysfunction involvement in alpha-synuclein aggregation: contribution to Parkinson’s disease Reunião das Doenças do Movimento
(Portugal)
2007 Changes in energy metabolism and apoptosis in Huntington's disease cybrids Reunião das Doenças do Movimento
(Portugal)
2007 Cross-talk between mitochondrial dysfunction and proteasome failure: relevance of oxidative stress in parkinson’s disease 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2007 Correlation between endoplasmic reticulum stress and mitochondrial dysfunction in Parkinson`s disease 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2007 Association between microtubules depolymerization and mitochondrial dysfunction in Parkinson's disease. 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2006 MPP+ induction of mitochondrial dependent Apoptosis requires functional mitochondria XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
(Portugal)
2006 Mitochondrial Dysfunction Enhances Mpp+ Induced Toxicity In Parkinson Disease XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
(Portugal)
2006 Mitochondrial dysfunction enhances MPP+ toxic effects in Parkinson’s disease cybrids Reunião das Doenças do Movimento
(Portugal)
2006 Evidências De Stress Oxidativo E Apoptose Em Modelos Celulares Da Doença De Huntington Reunião das Doenças do Movimento
(Portugal)
2006 Role of mitochondria on toxic effects induced by Abeta 1-40 – a comparative study on alzheimer’s disease and control cybrids Congresso em Gerentopsiquiatria
(Portugal)
2003 Zinc plays a role on amyloid beta-mediated cell death Zinc Signals
(Cayman Islands)
2003 Zinc, the good or the ugly in Alzheimer’s disease 17ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2002 A morte celular induzida por peptídeos beta-amilóide: relevância para o estudo da doença de Alzheimer Jornadas de Biologia Aplicada
(Portugal)
2001 Abeta 25-35 toxicity in NT2 rho+ and rho0 cells Reunião da Sociedade Portuguesa de Farmacologia
(Portugal)
2001 The Role of Ca++-calmodulin-dependent Ser-Thr phosphatase on amyloid beta-mediated toxicity 7º Reunião da Sociedade Portuguesa de Neurociências
(Portugal)
2001 The inhibitory effect of zinc on amyloid beta-toxicity 15ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
2000 Mitochondrial function in Alzheimer´s disease patients 14ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
1997 Aluminum as prooxidant in induced lipid peroxidation and stress related modifications of mitochondria respiratory chain complexes 11ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)
1997 Lipid, Protein and DNA Oxidation in Synaptosomes submitted to Oxidative Stress. The Role of the Glutathione System 11ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demência
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021 - Current Unveiling the role of gut dysbiosis in Schizophrenia pathology
Supervisor
 PhD Biosciences (PhD)
2019 - Current THE IMPACT OF BACTERIAL INFECTION IN GUT-FIRST PARKINSON’S DISEASE: THE INFLUENCE OF INNATE IMMUNITY ACTIVATION IN A-SYNUCLEIN EXPRESSION AND MITOCHONDRIAL DYSFUNCTION
Supervisor
 PhD BEB (PhD)
2011 - Current Unraveling Sirtuin 3 role in Parkinson’s disease
Supervisor
 PhD Biosciences
2007 - Current LABORATORY ROTATION SUPERVISION (18)
Supervisor
2006 - Current MASTER THESIS SUPERVISION (13)
Supervisor
2017 - 2018 O papel dos metabolitos microbianos na doença de Parkinson
Supervisor
 POST-DOC (Other)
2016 - 2018 The toxinogenic gut microbiome in sporadic Parkinson’s Disease: a quest for new “antiPDbiotics
Supervisor
 POST-DOC (Other)
2015 - 2016 The PARL-PGAM5-PINK1 axis in mitochondrial homeostasis: implications for Parkinson´s disease
Supervisor
 POST-DOC
2015 - 2015 The role of NMNAT2 in axon degeneration: relevance to Parkinson’s disease
Supervisor
 POST-DOC (Other)
2011 - 2015 Mitochondrial dysfunction disrupts autophagy through an axonal transport-dependent mechanism in MitoPark mice: the effects of microtubule stabilizers in the neurodegenerative process
Supervisor
 POST-DOC (Other)
2011 - 2014 Mitochondrial signaling pathway in Alzheimer´s disease: disclosure of new therapeutic targets
Supervisor
 PhD Biosciences (PhD)
2009 - 2014 Amyloid-beta peptide as a trigger of ER stress-mediated autophagy in endothelial cells: relevance to Alzheimer’s disease etiopathogenesis
Co-supervisor
 PhD in Biology, field of Cellular Biology (PhD)
2013 - 2013 Synaptic remodeling in Parkinson’s disease: a role for autophagy and mitochondrial trafficking/clearance
Supervisor
2007 - 2012 The cross-talk between endoplasmic reticulum and mitochondria in Parkinson’s disease: relevance to autophagic cell death
Supervisor
 PhD in Biomedicine (PhD)
2006 - 2010 Mitochondrial dysfunction towards protein aggregation in Parkinson disease: contribution of cytoskeletal disorganization
Supervisor
 PhD in Biology, field of Cellular Biology
2005 - 2006 BSC THESIS SUPERVISION (2)
Supervisor

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2013 - Current Member of the organizing comity of the XIII Reunião da Sociedade Portuguesa de Neurociências (2013)
Congress
2008 - Current “Investigação em Neurociências: Que Futuro” with the presence of Catarina Resende Oliveira, Carlos Lima, Inês Araújo. (2008)
Round table
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 “Disruption of mitochondria-associated membranes in Bipolar disorder: from molecular mechanisms to novel therapeutic targets
(Thesis) Arguer
 Ana Catarina Pereira (PhD)
2021 Targeting neuroinflammation and neurodegeneration in Parkinson’s disease
(Thesis) Main arguer
 Sara Rodrigues Oliveira (PhD)
2021 Metabolic remodeling and quality control mechanisms in Parkinson’s disease
(Thesis) Main arguer
 Cláudia Maria Carrudo de Deus (PhD)
2018 MASTER THESIS, AS AN EXAMINER. From 2008, Examiner of 16 candidates Universities of Coimbra, Algarve and Minho
(Thesis) Main arguer
 Several (Master)
2017 PHD THESIS, AS AN EXAMINER. From 2011, Examiner of 7 candidates, Universities of Coimbra, Porto, Lisboa and Minho
(Thesis) Main arguer
 Several (PhD)
2017 Localização subcelular da alpha-synuclein, e os seus efeitos ao nível da transcrição, em modelos celulares
(Thesis) Main arguer
 Raquel Pinho (PhD)

Association member

Society Organization name Role
2005 - Current SPB “Sociedade Portuguesa de Bioquímica” SFN “Society for Neuroscience”, EUA SPN “Sociedade Portuguesa de Neurociências” ASCB “American Society for Cell Biology”

Committee member

Activity description
Role 		Institution / Organization
2015 - Current PHD THESIS COMMITTEE OF PHDOC (Programa Inter-Universitário de Doutoramento em Envelhecimento e Doenças Crónicas)
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Neuroscience and Mental Health: A clinical and molecular overview in neuropsychiatric and neurodegenerative disorders PhD Course Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - Current Molecular Mechanisms of Disease PhD Course Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - Current Neurodegenerative Disorders BEB PhD Course Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - Current Fighting Infection PhD Course (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - Current Professor of the theoretical classes of Neurosciences, of the Master Course in Biomedical Research (MIB) of the University of Coimbra
2016 - Current Professor in the theoretical and practical classes of Investigação Aplicada of the degree in Medicine of the University of Coimbra, Portugal.
2013 - Current Biology of proteolysis in pathology PhD course (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - Current Professor of Biology of Aging classes, of the Master Course in Biomedical Engineering of the University of Coimbra. (Coordinator of this curricular unit)
2008 - Current COORDINATION OF GRADUATED COURSES: 6 PhD courses in the PhD Programme in Experimental Biology and Biomedicine and the Ciências da Saúde PhD programme. Biology of Aging Course, Neurodegenerative Disorders Course, Biology of Aging Course. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Faculdade de Direito, Portugal
2005 - Current Professor in the practical and theoretical classes of Cellular and Molecular Biology I, of the 1st year of the degree in Medicine of the University of Coimbra, Portugal. Cell and Molecular Biology (Licenciatura) Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - Current Professor in the practical and theoretical classes of Cellular and Molecular Biology, of the 1st year of the degree in Dental Medicine of the University of Coimbra, Portugal.
2005 - Current Professor in the practical and theoretical classes of Cellular and Molecular Biology II, of the 1st year of the degree in Medicine of the University of Coimbra, Portugal. (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2011 - 2011 Biology of Aging Course PhD (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2006 Lecture in the practical classes of Biochemistry, of the 1st year of the degree in Medicine (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024 - Current International project reviewer to Research Council of KU Leuven
Specialist
2023 - Current Research project expert reviewer to Research Council of KU Leuven
Specialist
2023 - Current Deutsche Forschungsgemeinschaft (DFG)
Specialist
2023 - Current International project reviewer to Agence Recherche France
Specialist
2022 - Current Research project expert reviewer to Research Council of KU Leuven
Specialist
2022 - Current International project reviewer to Israel Science Foundation
Specialist
2011 - Current REVIEWER OF INTERNATIONAL GRANTS - Alzheimer Society Grant Review - Alzheimer's Association Grant Review - Deutsche Forschungsgemeinschaft (DFG) - Israel Science Foundation - Italian Telephon Foundation Grant Review - Parkinson UK Grant Review - Parkinson's Disease Society Grant Review - Techniques and methods of research from the PhD programs of Heath Sciences and Inter-University of Aging and Chronic diseases - Technology Foundation STW (Holland) - The Austrian Science Fund FWF - The Luxembourg National Research Fund (FNR)
2024/02/11 - 2024/04/15 Jury for International Research Projects: National Science Center, Poland
Evaluator
2012 - 2013 PHD THESIS PROJECTS, AS AN EXAMINER 2. “S100B/RAGE axis: a promissory source of biomarkers and pharmacological tools in Parkinson’s disease” (2013) – PhD project in Medicine, Faculty of Medicine, University of Coimbra. (Sofia Andreia Domingues Viana) 1. “Lobular Breast Cancer as a model to evaluate the contribution of autophagy for E-cadherin downregulation” (2012) – PhD project in Medicine, Faculty of Medicine, University of Coimbra. (Olga Luísa Gomes Caramelo)
Evaluator

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017 2020 – Visão Saúde – No rasto do Intestino 2018 – Público – “Exercício saudável para um cérebro saudável” 2018 - 06 – 16 – Público - "Viagens sem Insónias". 2017 – Públio – “Viagens no Cérebro”

Interview (tv / radio show)

Program Topic
2012 - Current TV NEWS 2014 - 03 - 20 - SIC - Prémio Janssen Neurociências 2014 - 03 - 15 - RTP1 - Prémio Janssen Neurociências 2012 - 08 - 14 - TVI - Parkinson - UC. RADIO NEWS 2019 – 03 – 17 – RUC – Ciência aos Domingos 2018 – 07 – RUC – O Cérebro e o Desporto (Jogos Universitários) 2017 -03 – 16 – RUC - Debate on the Relevance of the Research in Neurosciences 2014 - 03 - 18 – Renascença – PPrémio Janssen Neurociências 2012 - 08 - 13 - TSF - Parkinson - investigação UC.
Distinctions

Award

2023 Pfizer best paper
Pfizer Portugal, Portugal
2016 Distinguished with the Prémio Santa Casa Neurociências Mantero Belard, from Santa Casa da Misericórdia de Lisboa.
2014 Distinguished with the Janssen Neuroscience Award, from Janssen Pharmaceutics
2014 Best oral communication
2013 Distinguished with the Silver Medal for Scientific Research Achievements, from the Portuguese Ministry of Health
2013 Best oral communication
2012 Best paper in basic science
2012 Best oral communication
2011 Best oral communication
2010 Best oral communication

Other distinction

2020 Selected to to attend ERC Consolidator interview
2020 World’s Top 2% Scientists ranking
Stanford University, United States
2019 EU fellowship to attend ERC Consolidator interview. Brussels, Belgium
1999 FCT Portuguese Fellowship, Abroad Scientific training at Department of Neurology, University of Virginia Health System, Virginia 22908, EUA
1998 FCT Portuguese Fellowship, Abroad Scientific training at Department of Neurosciences, Royal Free Hospital School of Medicine, London, NW3 2PF, UK