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Dr. Attila Köfalvi is a neurobiologist, Principal Investigator at CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. He received his PhD diplom with summa cum laude in Basic Medicine/Neurosciences at the Semmelweis Medical University, Budapest, in 2004, in a joint programme with the Nathan Smith Kline Institute (Orangeburg, NY) and the Institute of Experimental Medicine, Budapest, Hungary. He was an IBRO-funded post-doctoral fellow between 2004 and 2007 at CNC in Coimbra, before receiving the associate researcher position. He received 4 honors/awards so far, including a Young Investigator membership of the Network of European Neuroscience Institutes in 2009. He is integrated in the network of Associate Laboratories of the Portuguese Science Foundation. His research group is called "Laboratory of Neuromodulation and Metabolism", where the role of neuromodulators such as adenosine, endocannabinoids and insulin on neural communication, brain energy metabolism and brain disorders are studied, recently with emphasis on sexual dimorphism. He tutored 3 PhD theses and numerous MSc and BSc theses. He was promotor and principal investigator of so far 3 international projects/cooperations, 3 national grants, among them two FCT projects with a sum of 190,000 Euros, and two contracts with NIDA/NIH to study an animal model of Restless Legs Syndrome. He authored 67 publications with a sum Impact Factor of ~227, with a sum of ~3200 citations and an H-factor of 27, and reviewed 115 papers as a referee, as per Web of Science. He was the Editor and partial author of the book ¿Cannabinoids and the Brain¿ NY: Springer, ISBN: 978-0-387-74348-6. He holds Good Laboratory Practice certificate (2001) and Category "C" qualification for directing animal experiments from the Federation of European Laboratory Animal Science Associations (2009). He is fluent in Portuguese, English (C2) and Hungarian. He has been the consultant for the Health Council of the Portuguese Parliament in 2019 for the legislation of medical cannabis in Portugal. He is a father of three. In his non-existent free time he pursues his first international chess title, by playing for the chess club of the Académica Association of the Coimbra University.
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Identification

Personal identification

Full name
Attila Köfalvi

Citation names

  • Köfalvi (Kofalvi, Käfalvi), Attila

Author identifiers

Ciência ID
561A-78AC-B857
ORCID iD
0000-0001-6910-9707
Google Scholar ID
http://scholar.google.com/citations?user=cRyWZlYAAAAJ
Researcher Id
O-9815-2017
Scopus Author Id
8595603500

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Hungarian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2004/09/01 - 2007/07/31
Concluded
 Life Sciences, Neuroscience (Pós-doutoramento)
Fundação para a Ciência e a Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/09/01 - 2004/11/06
Concluded
 Neurociências - Neurosciences (Doutoramento)
Semmelweis Egyetem, Hungary
"The role of nicotinic acetylcholine and endocannabinoid receptors in the modulation of transmitter releaase in the central nervous system" (THESIS/DISSERTATION)
 Summa Cum Laude
1994/09/01 - 1999/07/08
Concluded
 Biologia (Licenciatura)
Eotvos Lorand Tudomanyegyetem Természettudományi Kar, Hungary
"Role of nicotinic acetylcholine and cannabinoid receptors in the regulation of neurotransmitter release in the central nervous system" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2024/01/01 - Current Principal Investigator (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2007/08/01 - 2023/12/31 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2004/02/01 - 2007/07/30 Post-doctor fellow, IBRO fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/09/01 - 2004/05/31 Research Fellow, PhD student Magyar Tudományos Akadémia Kísérleti Orvostudományi Kutatóintézet, Hungary
2003/03/01 - 2003/08/31 Visitor researcher Nathan S Kline Institute, United States
1996/09/01 - 1999/07/30 Undergraduate Researcher Magyar Tudományos Akadémia Kísérleti Orvostudományi Kutatóintézet, Hungary
1995/09/01 - 1996/08/30 Undergraduate researcher Országos Klinikai Idegtudományi Intézet, Hungary
Projects

Grant

Designation Funders
2016/03/01 - 2019/02/28 Synaptic mechanisms involved in the brain cannabinoid actions and their modulation by adenosine receptors: implications for memory and mood control
PTDC/DTP-FTO/3346/2014
Other
Instituto de Medicina Molecular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03/17 - 2012/07/31 Mapping the metabolic and neuromodulator role of insulin in the hippocampus
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105663/PT
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/03/17 - 2012/06/16 Demonstrating that A2A adenosine receptors control glutamatergic synaptic plasticity through CB1 cannabinoid receptors in the striatum, thus providing attracting therapeutic targets
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/100729/PT
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

University of Aberdeen, United Kingdom

The Collège de France, INSERM U667, France
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2009/12/31 Interactions between the purinergic and the endocannabinoid system in pain sensation
TÉT-GRICES/PT-18/2007
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 GRICES - Gabinete de Relações Internacionais da Ciência e do Ensino Superior
Concluded
2006/01/01 - 2007/12/31 Targeted Lipidomics in Basal Ganglia Disorders – Toward a Novel Anticholinergic Therapy
III/BIO/56/2005
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Instituto de Investigação Interdisciplinar
Concluded
2005/01/01 - 2006/12/31 Modulation of transmitters involved in the pain sensation – from the periphery to the central nervous system. New perspectives in analgesic therapy
TÉT-GRICES/2004
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Semmelweis Egyetem, Hungary
GRICES - Gabinete de Relações Internacionais da Ciência e do Ensino Superior
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2023/03/31 IBRO Meetings Support 2023 for the MCC Congress
none
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2017/04/01 - 2021/03/31 NIDA - Neuromodulation by adenosine receptors
PO# HHSN271201700216P
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Institute on Drug Abuse Behavioral Neuroscience Research Branch
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/03/01 - 2019/02/28 Mecanismos sinápticos envolvidos nas acções dos canabinoides no cérebro e sua modulação por receptores de adenosina: implicações para a regulação do humor e memória
PTDC/DTP-FTO/3346/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/03/17 - 2012/06/16 Demonstração de que os receptores de adenosina A2A controlam a plasticidade sináptica glutamatergica via dos receptores de canabinóide CB1 no corpo estriado, fornecendo assim alvos terapêuticos atrativos
PTDC/SAU-NEU/100729/2008
University of Aberdeen Institute of Medical Sciences, United Kingdom

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Köfalvi, Attila. Cannabinoids and the Brain. Springer-Verlag. 2008.
    10.1007/978-0-387-74349-3_9
Book chapter
  1. Nagy, Istvan; White, John P. M.; Paule, Cleoper C.; Köfalvi, Attila. "An Historical Introduction to the Endocannabinoid and Endovanilloid Systems". In Cannabinoids and the Brain, 3-13. Springer US, 2008.
    10.1007/978-0-387-74349-3_1
  2. Köfalvi, Attila. "Alternative Interacting Sites and Novel Receptors for Cannabinoid Ligands". In Cannabinoids and the Brain, 131-160. Springer US, 2008.
    10.1007/978-0-387-74349-3_9
  3. Matias, Isabel; Di Marzo, Vincenzo; Köfalvi, Attila. "Endocannabinoids in Energy Homeostasis and Metabolic Disorders". In Cannabinoids and the Brain, 277-316. Springer US, 2008.
    10.1007/978-0-387-74349-3_14
  4. Köfalvi, Attila; Fritzsche, Markus. "The Endocannabinoid System is a Major Player in Schizophrenia". In Cannabinoids and the Brain, 485-528. Springer US, 2008.
    10.1007/978-0-387-74349-3_22
Conference abstract
  1. Köfalvi (Kofalvi, Käfalvi), Attila ; Morgado, Carla; Pedro, Joana Reis; Lemos, Cristina; Baptista, FI; Gaspar, Joana M.; Ambrósio, António F.; et al. "Streptozotocin-induced type-1 diabetes triggers deregulation of cerebral glucose metabolism identical to genetic deletion of the CB1 cannabinoid receptor". Paper presented in 8th FENS Forum of Neurocience, Barcelona, 2012.
  2. Gomes CA; Machado NJ; Ardais AP; Rodrigues DI; Kaster MP; Garção P; Silva H; et al. "Modification of the adenosine modulation system in an animal model of depression". 2012.
  3. Baptista, FI; Pedro, Joana Reis; Duarte, João; Fernandes, Ângela; Gaspar, Joana; Nogueira, Célia; Carvalho, Eugenia; Ambrósio, António F.; Köfalvi (Kofalvi, Käfalvi), Attila. "Neocortical impairment of glucose homeostasis in the early phase of rat model of type-1 diabetes". Paper presented in Federation of European Neuroscience Societies, Amsterdan, 2010.
Conference poster
  1. Paula M. Canas; Veloso, Caroline; Ferreira, Samira G.; Cunha, Rodrigo A.; Attila, Kofalvi. Corresponding author: Attila, Kofalvi. "Adenosine Receptors Control Forebrain Glucose Uptake". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  2. Agostinho, Paula; Dias, Cândida; Carvalho, RA; Carvalho, R; Carvalho Rui; Ledo, Ana; Laranjinha, João; Madeira, Daniela; Liliana Dias; et al. Corresponding author: Attila Köfalvi. "Astrocytic GPR55 Receptors Fuel Glycolysis". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  3. Matilde S. Rodrigues; Cunha, Rodrigo A.; Ferre, Sergi; Ferreira, Samira G.; Attila Köfalvi. Corresponding author: Attila Köfalvi. "Reduced A1/A2A Adenosine Receptor Ratio in Corticostriatal Terminals in a Rat Model of Restless Legs Syndrome". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  4. Carla S. Santos-Silva; Carolina Xavier; Paula Valente-Silva; Inês Dinis; Cláudia Ferreira; Paula M. Canas; Henrique B. Silva; Cunha, Rodrigo A.; Attila Köfalvi. Corresponding author: Attila Köfalvi. "Lecture: Crosstalk between Cannabinoid CB1 and Insulin-like Growth Factor-1 Receptors opposingly shapes the activity of hippocampal CA3-CA1 synapses in fasted and fed rats". Paper presented in Meeting of the Portuguese Pharmacological Society, 2020.
  5. Matilde S. Rodrigues; Dias, Cândida; Cláudia Ferreira; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Attila Köfalvi. Corresponding author: Attila Köfalvi. "Lecture: An optimized spectrophotometric assay reveals increased 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease". Paper presented in Meeting of the Portuguese Pharmacological Society, 2020.
  6. Daniel Moreira-Silva; Silva, Henrique B.; Carolina Xavier; Paula Valente-Silva; Paula M. Canas; Cunha, Rodrigo A.; Attila Köfalvi. Corresponding author: Attila Köfalvi. "Lecture: STREPTOZOTOCIN PREVENTS HIPPOCAMPAL LONG-TERM POTENTIATION VIA ENDOCANNABINOID TONE ON POST-SYNAPTIC CB1 RECEPTORS". Paper presented in XLIX Meeting of the Portuguese Pharmacological Society, XXXVII Meeting of Clinical Pharmacology, XVIII Meeting of Toxicology, 2019.
  7. Douglas T. Leffa; Pandolfo, Pablo; Gonçalves, Nelio; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al. "Lecture: ADENOSINE A2A RECEPTORS IN THE RAT PRELIMBIC MEDIAL PREFRONTAL CORTEX CONTROL DELAY-BASED COST-BENEFIT DECISION MAKING". Paper presented in XLIX Meeting of the Portuguese Pharmacological Society, XXXVII Meeting of Clinical Pharmacology, XVIII Meeting of Toxicology, 2019.
  8. Attila Köfalvi; Cai, Ning-Sheng; Yano, Hideaki; Moreno, Estefanía; Casadó, Vicent; Ferreira, Samira G.; Ana Maria Ferreira Sousa Sebastião; Cunha, Rodrigo A.; Ferre, Sergi. Corresponding author: Attila Köfalvi. "Lecture: ALLOSTERIC MODULATIONS OF G PROTEIN-MEDIATED SIGNALING WITHIN THE A2AR-CB1R HETEROTETRAMER". Paper presented in XLVII Meeting of the Portuguese Pharmacological Society, XXXV Meeting of the Clinical Pharmacology, 2017.
  9. Köfalvi, Attila; E. Sylvester Vizi, MD, PhD, DSc, Habil.; Beáta Sperlágh, MD, PhD, DSc, Habil.. Corresponding author: Beáta Sperlágh, MD, PhD, DSc, Habil.. "Effect of Nicotine on GABA Release from Rat Hippocampal Slices via a7-Type Neuronal Nicotinic Acetylcholine Receptors.". Paper presented in 7th Annual Meeting of the Hungarian Neuroscience Society,, 1999.
Journal article
  1. Sergi Ferre; Attila Köfalvi; Francisco Ciruela; Zuzana Justinova; Marco Pistis. "Targeting corticostriatal transmission for the treatment of cannabinoid use disorder". Trends in Pharmacological Sciences 44 8 (2023): 495-506. http://dx.doi.org/10.1016/j.tips.2023.05.003.
    10.1016/j.tips.2023.05.003
  2. Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré. "Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome". Molecules (2022): https://doi.org/10.3390/molecules27051489.
    10.3390/molecules27051489
  3. Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia. "Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.". Experimental gerontology 154 (2021): 111528. https://doi.org/10.1016/j.exger.2021.111528.
    Published • 10.1016/j.exger.2021.111528
  4. Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila. "An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14944.
    10.1111/ejn.14944
  5. Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al. Corresponding author: Köfalvi, Attila. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
    10.1016/j.brainresbull.2020.05.004
  6. Köfalvi, Attila. "The Yin and Yang of Adenosine Receptors: A Piquant Story". Journal of Caffeine and Adenosine Research (2020): http://dx.doi.org/10.1089/caff.2020.0004.
    10.1089/caff.2020.0004
  7. Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al. "Control of glutamate release by complexes of adenosine and cannabinoid receptors". BMC Biology 18 1 (2020): http://dx.doi.org/10.1186/s12915-020-0739-0.
    10.1186/s12915-020-0739-0
  8. Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M.. "Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism". Neuropharmacology 155 (2019): 10-21. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003.
    10.1016/j.neuropharm.2019.05.003
  9. Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila. "Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain". Brain Research Bulletin 147 (2019): 101-109. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024.
    10.1016/j.brainresbull.2019.01.024
  10. Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.". Cell death & disease (2018): http://europepmc.org/abstract/med/29463792.
    10.1038/s41419-018-0351-1
  11. Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al. "Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making". Frontiers in Molecular Neuroscience 11 (2018): https://doi.org/10.3389%2Ffnmol.2018.00475.
    10.3389/fnmol.2018.00475
  12. Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al. "Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions". eneuro 5 6 (2018): ENEURO.0385-18.2018. https://doi.org/10.1523%2Feneuro.0385-18.2018.
    10.1523/eneuro.0385-18.2018
  13. Leal, Ermelindo C; Pirzgalska R; Dorinda Marques-da-Silva; Moura, Liane; Espinoza D; Ledent, C.; Köfalvi, Attila; Carvalho, Eugenia. "Conference Paper: Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression.". Diabetologia 60 S1 (2017): 119-119. http://dx.doi.org/10.1007/s00125-017-4350-z.
    10.1007/s00125-017-4350-z
  14. Katalin Solymosi; Köfalvi, Attila. "Cannabis: A Treasure Trove or Pandora's Box?". Mini-Reviews in Medicinal Chemistry 17 13 (2017): https://doi.org/10.2174%2F1389557516666161004162133.
    10.2174/1389557516666161004162133
  15. de Ceballos ML; Köfalvi A. "Boosting brain glucose metabolism to fight neurodegeneration?". (2017): http://europepmc.org/abstract/med/28184023.
    10.18632/oncotarget.15131
  16. Attila Köfalvi; Cristina Lemos; Ana M. Martín-Moreno; Bárbara S. Pinheiro; Luis García-García; Miguel A. Pozo; Ângela Valério-Fernandes; et al. "Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease". Neuropharmacology 110 (2016): 519-529. https://doi.org/10.1016/j.neuropharm.2016.03.015.
    10.1016/j.neuropharm.2016.03.015
  17. Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al. "Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.". (2016): http://europepmc.org/abstract/med/27762079.
    10.1111/cns.12649
  18. Bárbara S. Pinheiro; Cristina Lemos; Fernanda Neutzling Kaufmann; Joana M. Marques; Carla S. da Silva-Santos; Eugénia Carvalho; Ken Mackie; et al. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin". Brain Research Bulletin 124 (2016): 222-230. https://doi.org/10.1016/j.brainresbull.2016.05.009.
    10.1016/j.brainresbull.2016.05.009
  19. Nuno J. Machado; Ana Patrícia Simões; Henrique B. Silva; Ana Paula Ardais; Manuella P. Kaster; Pedro Garção; Diana I. Rodrigues; et al. "Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses". Molecular Neurobiology 54 2 (2016): 1552-1563. https://doi.org/10.1007%2Fs12035-016-9774-9.
    10.1007/s12035-016-9774-9
  20. Lemos, Cristina; Pinheiro, Bárbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Köfalvi, Attila. "Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic Signalling 11 4 (2015): 561-569. http://dx.doi.org/10.1007/s11302-015-9474-3.
    10.1007/s11302-015-9474-3
  21. Rafael M. Bitencourt; Alán Alpár; Valentina Cinquina; Samira G. Ferreira; Bárbara S. Pinheiro; Cristina Lemos; Catherine Ledent; et al. "Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents". Neurochemistry International (2015): http://dx.doi.org/10.1016/j.neuint.2015.07.014.
    10.1016/j.neuint.2015.07.014
  22. Paula Valente-Silva; Cristina Lemos; Attila Köfalvi; Rodrigo A. Cunha; John G. Jones. "Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices". NMR Biomed. 28 9 (2015): 1111-1116. http://dx.doi.org/10.1002/nbm.3355.
    10.1002/nbm.3355
  23. Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al. "Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus". European Journal of Neuroscience (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923353859&partnerID=MN8TOARS.
    10.1111/ejn.12851
  24. Ferreira, S.G.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; et al. "Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2015): 1074-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS.
    10.1111/bph.12970
  25. Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; et al. "Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease". PLoS ONE 9 12 (2014): e114216. http://dx.doi.org/10.1371/journal.pone.0114216.
    10.1371/journal.pone.0114216
  26. Pandolfo, P.; Machado, N.J.; Köfalvi, A.; Takahashi, R.N.; Cunha, R.A.. "Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder". European Neuropsychopharmacology 23 4 (2013): 317-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881549136&partnerID=MN8TOARS.
    10.1016/j.euroneuro.2012.04.011
  27. Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A.. "Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum". British Journal of Pharmacology 169 7 (2013): 1600-1611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS.
    10.1111/bph.12234
  28. Köles, L.; Garção, P.; Zádori, Z.S.; Ferreira, S.G.; Pinheiro, B.S.; da Silva-Santos, C.S.; Ledent, C.; Köfalvi, A.. "Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain". Brain Research Bulletin 97 (2013): 126-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880816335&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2013.06.007
  29. Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A.. "CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus". Neurochemistry International 60 1 (2012): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.10.019
  30. Lemos, C.; Valério-Fernandes, Â.; Ghisleni, G.C.; Ferreira, S.G.; Ledent, C.; de Ceballos, M.L.; Köfalvi, A.. "Impaired hippocampal glucoregulation in the cannabinoid CB 1 receptor knockout mice as revealed by an optimized in vitro experimental approach". Journal of Neuroscience Methods 204 2 (2012): 366-373. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855251226&partnerID=MN8TOARS.
    10.1016/j.jneumeth.2011.11.028
  31. Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A.. "Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences". Neurochemistry International 61 2 (2012): 219-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS.
    10.1016/j.neuint.2012.05.009
  32. Richter, H.; Teixeira, F.M.; Ferreira, S.G.; Kittel, Á.; Köfalvi, A.; Sperlágh, B.. "Presynaptic a2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat". Neuropharmacology 63 5 (2012): 784-797. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864451017&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2012.06.003
  33. Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia. "Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.". Diabetologia 54 S1 (2011): 458-458. http://dx.doi.org/10.1007/s00125-011-2276-4.
    10.1007/s00125-011-2276-4
  34. Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila. "Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum". European Journal of Pharmacology 655 1-3 (2011): 38-45. http://dx.doi.org/10.1016/j.ejphar.2011.01.013.
    10.1016/j.ejphar.2011.01.013
  35. Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P.. "Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission". Journal of Neurochemistry 116 2 (2011): 273-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.07101.x
  36. Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F.. "Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina". Brain Research 1383 (2011): 257-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS.
    10.1016/j.brainres.2011.01.071
  37. De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G.. "Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging". Cellular and Molecular Neurobiology (2011): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS.
    10.1007/s10571-011-9673-6
  38. Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al. "Molecular reorganization of endocannabinoid signalling in Alzheimer's disease". Brain 134 4 (2011): 1041-1060. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS.
    10.1093/brain/awr046
  39. Tebano MT; Martire, A.; Köfalvi, Attila; Chiodi, V.; Ferrante A; Domenici MR; Ferreira, Samira G.; Cunha, Rodrigo A.; Popoli, P.. "Conferenc Paper: Complex regulation of CB1-mediated effects by activation and blockade of striatal adenosine A2A receptors.". Purinergic Signalling 6 S1 (2010): 19-19. http://dx.doi.org/10.1007/s11302-010-9187-6.
    10.1007/s11302-010-9187-6
  40. Ferreira, Samira G.; Köfalvi, Attila; Cunha, Rodrigo A.. Corresponding author: Köfalvi, Attila. "Conferenc Paper: Presynaptic A2A adenosine and CB1 cannabinoid receptors inhibit the function of one another at corticostriatal terminals.". Purinergic Signalling 6 S1 (2010): 44-44. http://dx.doi.org/10.1007/s11302-010-9187-6.
    10.1007/s11302-010-9187-6
  41. Augusto, Elisabete; Paula M. Canas; Lisiane O. Porciúncula; Tiago M. Alfaro; Andrade GM; Köfalvi, Attila; Agostinho PM; Cunha, Rodrigo A.. Corresponding author: Cunha, Rodrigo A.. "Conferenc Paper: Blockade of synaptic adenosine A2A receptor prevents convulsion-induced damage.". Purinergic Signalling 6 S1 (2010): 108-108. http://dx.doi.org/10.1007/s11302-010-9187-6.
    Open access • 10.1007/s11302-010-9187-6
  42. Pandolfo, P.; Machado NM; Köfalvi, Attila; Takahashi RN; Cunha, Rodrigo A.. "Conferenc Paper: Chronic caffeine treatment during adolescence improves behavioral flexibility in an animal model of attention deficit hyperactivity disorder.". Purinergic Signalling 6 S1 (2010): 108. http://dx.doi.org/10.1007/s11302-010-9187-6.
    Open access • 10.1007/s11302-010-9187-6
  43. Tebano MT; Martire A; Köfalvi, Attila; Chiodi, V.; Domenici MR; Pepponi R; Ferrante A; et al. "Conferenc Paper: Dual regulatory role of pre- and post-synaptic adenosine A2A receptors on CB1-mediated effects in the striatum.". Purinergic Signalling 6 1 (2009): 51-51. http://dx.doi.org/10.1007/s11302-009-9171-1.
    10.1007/s11302-009-9171-1
  44. Köfalvi, Attila. Corresponding author: Köfalvi, Attila. "Conferenc Paper: When modulators of synaptic plasticity meet at endocannabinoid signalling: comparing dyskinesias with psychosis.". Journal of Neurochemistry 110 s1 (2009): 103-104. http://dx.doi.org/10.1111/j.1471-4159.2009.06064_27.x.
    10.1111/j.1471-4159.2009.06064_27.x
  45. Attila, Kofalvi. "Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum". Frontiers in Neuroscience 3 (2009): http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128.
    10.3389/conf.neuro.01.2009.11.128
  46. Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A.. "Modification upon aging of the density of presynaptic modulation systems in the hippocampus". Neurobiology of Aging 30 11 (2009): 1877-1884. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2008.01.003
  47. Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "N-acyldopamines control striatal input terminals via novel ligand-gated cation channels". Neuropharmacology 56 3 (2009): 676-683. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2008.12.001
  48. Duarte, JMN; Nogueira, C.; Carvalho, RA; Carvalho, R; Carvalho Rui; Mackie, K.; Oliveira, CR; Cunha, Rodrigo A.; Köfalvi, Attila. Corresponding author: Köfalvi, Attila. "Conferenc Paper: CB1 cannabinoid receptors in the physiopathology of hippocampal glucose homeostasis.". Journal of Neurochemistry 102 s1 (2007): 115-115. http://dx.doi.org/10.1111/j.0022-3042.2007.04727.x.
    10.1111/j.0022-3042.2007.04727.x
  49. Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A.. "Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus". British Journal of Pharmacology 151 4 (2007): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS.
    10.1038/sj.bjp.0707252
  50. Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al. "Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments". Journal of Neurochemistry 101 2 (2007): 355-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04386.x
  51. Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A.. "Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats". Experimental Neurology 204 1 (2007): 479-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS.
    10.1016/j.expneurol.2006.11.013
  52. Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S.. "Regulation of neurotransmitter release by presynaptic P2X receptors". Autonomic and Autacoid Pharmacology 26 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS.
  53. Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G.. "CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action". Molecular Pharmacology 70 4 (2006): 1236-1245. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS.
    10.1124/mol.106.024661
  54. Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F.. "Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))". Journal of Neuroscience 26 47 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS.
  55. Köfalvi, A.; Oliveira, C.R.; Cunha, R.A.. "Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals". Neuroscience Letters 403 1-2 (2006): 151-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS.
    10.1016/j.neulet.2006.04.030
  56. Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al. "Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia". Journal of Neurochemistry 95 5 (2005): 1421-1437. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2005.03465.x
  57. Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B.. "Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis". Journal of Neuroscience 25 11 (2005): 2874-2884. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4232-04.2005
  58. Günther, A.; Köfalvi, Attila; Reinhardt, R.; Franke, F.; Madarász, E.; Vizi, E. Sylvester; Schneider, D.; et al. "Conferenc Paper: Ischemia induced up-regulation of P2X7 receptors on GABAergic neurons in corticoencephalic cell cultures.". European Journal of Neurology 11 s2 (2004): 58-58. http://dx.doi.org/10.1111/j.1468-1331.2004.00919.x.
    10.1111/j.1468-1331.2004.00919.x
  59. Papp, L.; Balázsa, T.; Köfalvi, Attila; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B.. "Conferenc Paper: The role of presynaptic P2X receptors in the regulation of tritiated NA release from rat hippocampal slices.". Fundamental and Clinical Pharmacology 18 s1 (2004): 37-37. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x.
    10.1111/j.1472-8206.2004.00260.x
  60. Köfalvi, Attila; Ricardo J. Rodrigues; Cunha, Rodrigo A.; Catherine Ledent; Vizi, E. Sylvester; Sperlágh, B.. "Conferenc Paper: Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the rodent striatum.". Fundamental and Clinical Pharmacology 18 s1 (2004): 57-57. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x.
    10.1111/j.1472-8206.2004.00260.x
  61. Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B.. "P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices". Journal of Pharmacology and Experimental Therapeutics 310 3 (2004): 973-980. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS.
    10.1124/jpet.104.066712
  62. Sperlágh, B.; Köfalvi, Attila; E. Sylvester Vizi, MD, PhD, DSc, Habil.. Corresponding author: E. Sylvester Vizi, MD, PhD, DSc, Habil.. "Conferenc Paper: Regulation of transmitter release in the CNS by cannabinoid receptors.". Pharmacology 72 2 (2004): 141-141. http://dx.doi.org/10.1159/000080185.
    10.1159/000080185
  63. Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B.. "Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action". European Journal of Neuroscience 18 7 (2003): 1973-1978. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS.
    10.1046/j.1460-9568.2003.02897.x
  64. Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester. "Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus". Journal of Neurochemistry 81 6 (2002): 1196-1211. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x.
    10.1046/j.1471-4159.2002.00920.x
  65. Köfalvi, Attila; Baranyi M; Vizi ES; Sperlagh, B.. Corresponding author: Sperlagh, B.. "Conferenc Paper: ATP releases [3H]GABA from rat hippocampal slices via P2X7 receptor activation.". Fundamental and Clinical Pharmacology 15 S1 (2001): 135-135. http://dx.doi.org/10.1046/j.1472-8206.2001.00113.x.
    10.1046/j.1472-8206.2001.00113.x
  66. Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A.. "Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens". Neurochemical Research 26 8-9 (2001): 951-957. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS.
    10.1023/A:1012336601854
  67. Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S.. "Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord". Neurochemistry International 39 1 (2001): 59-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS.
    10.1016/S0197-0186(00)00124-8
  68. Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; E. Sylvester Vizi, MD, PhD, DSc, Habil.; Sperlagh, B.. Corresponding author: Sperlagh, B.. "Cellular Neurophysiology". Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus. 526 suppl (2000): http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x.
    10.1111/j.1469-7793.2000.tb00269.x
  69. Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; Vizi ES; Sperlágh, B.. Corresponding author: Sperlágh, B.. "Conference Paper: Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.". The Journal of Physiology 526 suppl (2000): 64-65. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x.
    10.1111/j.1469-7793.2000.tb00269.x
  70. Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F.. "GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus". Neuroscience 100 4 (2000): 797-804. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS.
    10.1016/S0306-4522(00)00286-4
  71. Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S.. "Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation". Journal of Pharmacology and Experimental Therapeutics 295 2 (2000): 453-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS.
  72. Köfalvi, Attila; E. Sylvester Vizi, MD, PhD, DSc, Habil.; Beáta Sperlágh, MD, PhD, DSc, Habil.. Corresponding author: Beáta Sperlágh, MD, PhD, DSc, Habil.. "Conference Paper: The Effect of Nicotine on GABA Release from Rat Hippocampal Slices is Mediated via alpha7-Type Homopentameric Neuronal Nicotinic Acetylcholine Receptors". Fundamental and Clinical Pharmacology 13 S1 (1999): 128. http://dx.doi.org/10.1111/j.1472-8206.1999.tb00383.x.
    10.1111/j.1472-8206.1999.tb00383.x
  73. Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F.. "Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons". Journal of Neuroscience 19 11 (1999): 4544-4558. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345621691&partnerID=MN8TOARS.
Newsletter article
  1. "Canábis com Efeitos Positivos no Alzheimer", Diário As Beiras, 2016
  2. "Investigador da Universidade de Coimbra descobre efeito positivo da canábis no Alzheimer", SAPO Lifestyle, 2016, http://lifestyle.sapo.pt/saude/noticiassaude/ artigos/investigadordauniversidadedecoimbradescobreefeitodacanabisnadoencadealzheimer.

Other

Other output
  1. Evaluation of the Law Proposal Draft No. 726/XIII/3rd. I evaluated and discussed in the Portuguese Parlament the draft of the Law Proposal Parlamental N.º 726/XIII/3.ª of the Portuguese party "BLOCO DE ESQUERDA" entitled "REGULA A UTILIZAÇÃO DA PLANTA, SUBSTÂNCIAS E PREPARAÇÕES DE CANÁBIS PARA FINS MEDICINAIS". 2018. Attila Köfalvi.
  2. Evaluation of the Law Proposal Draft No. 727/XIII/3rd. I evaluated and discussed in the Portuguese Parlament the draft of the Law Proposal Parlamental No. 727/XIII/3rd of the Portuguese party "Pessoas, Animais, Natureza", entitled "Pela admissibilidade de utilização de canábis para fins medicinais". 2018. Attila Köfalvi.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/05/22 Cannabis and the Endocannabinoid System APLICAÇÕES MEDICINAIS DA CANNABIS
Escola Superior de Saúde Dr Lopes Dias (Castelo-Branco, Portugal)
2017/11/19 Canábis: Uma caixa de tesouro ou a caixa de Pandora? As Jornadas da Cannabis – Cannadouro – 2017, Porto
Associação Cannativa (Porto, Portugal)
2013/10/11 Aula sobre as questões de saúde em Cabo Verde, com ênfase sobre o vício Mental Hygiene lecture for high-school students
Escola Armando Napoleão Fernandes (Assomada, Cape Verde)
2011/09/29 Endocannabinoid System in Physiology and Pathology of Pain Neuroquímica e Biologia da Dor - Postgraduate Course on Pain Medicine
Universidade de Coimbra Faculdade de Medicina (Coimbra, Portugal)
2011/08/30 Presynaptic neuromodulation in the dorsolateral striatum Private invitation
Universidade Federal do Paraná (Curitiba, Brazil)
2011/08/24 Presynaptic neuromodulation in the dorsolateral striatum FESBE-SBNeC joint meeting
FESBE-SBNeC (Rio de Janeiro, Brazil)
2011/08/23 The cannabino-corticofrontal conspiracy FESBE-SBNeC joint meeting
FESBE-SBNeC (Rio de Janeiro, Brazil)
2010/11/26 Endocannabinoid control of hippocampal glucose metabolism in Alzheimer-type pathology: from in vitro to in vivo studies by PET. Multimodal imaging of the tissue microvasculature in health and disease,
(Madrid, Spain)
2010/09/25 Impaired hippocampal glucose metabolism by decreased CB1 cannabinoid receptor-GSK3 signalling in animal models of Alzheimer’s disease. I International Health Congress in Gaia
(Porto, Portugal)
2010/09/16 The endocannabinoid system of the brain Biochemistry Seminars of the Postgraduate Course in Biological Sciences
Universidade Federal do Rio Grande do Sul (Porto Alegre, Brazil)
2010/09/14 1) The endocannabinoid system of the brain 2) Presynaptic neuromodulation in the dorsolateral striatum Post-graduation programme in Neuropharmacology
Universidade Federal de Santa Catarina (Florianópolis, Brazil)
2010/08/11 Presynaptic neuromodulation in the dorsolateral striatum – Heterologous interactions and new players. SBNeC meeting
Sociedade Brasileira de Neurociências e Comportamento (SBNeC) (Caxambu, Brazil)
2010/08/10 Impaired hippocampal glucose metabolism by decreased CB1 cannabinoid receptor-GSK3 signalling in animal models of Alzheimer’s disease. SBNeC meeting
Sociedade Brasileira de Neurociências e Comportamento (SBNeC) (Caxambu, Brazil)
2010/05/07 Impaired hippocampal glucose metabolism by decreased CB1 cannabinoid receptor-GSK3a signalling in TgApp mice. ENI-Net Final Meeting
European Neuroscience Institutes (Coimbra, Portugal)
2009/07/14 When modulators of synaptic plasticity meet at endocannabinoid signalling: comparing dyskinesias with psychosis. 4th ESN Conference on Advances in Molecular Mechanisms of Neurological Disorders
European Society for Neurochemistry (Leipzich, Germany)
2009/05/21 Presynaptic neuromodulation by cannabinoids in the dorsolateral striatum – new players besides CB1 and TRPV1 receptors. ENI-Net Annual Meeting
European Neuroscience Institutes (Crete, Greece)
2006/12/17 Mapping the distribution and physiological and pathological role of CB1 cannabinoid receptors in the brain. ENI-Net Christmas Meeting
European Neuroscience Institutes (Seville, Spain)
2006/09/21 Endocannabinoid signaling in the nigrosrostiatal system with reference to Parkinson's disease. 10th Meeting of the Hungarian Alzheimer’s Association and the Hungarian Parkinson and Neuropathology Associations
Hungarian Alzheimer’s Association and the Hungarian Parkinson and Neuropathology Associations (Szeged, Hungary)
2006/03/09 The endocannabinoid system in schizophrenia – facts and further assumptions. 26th European Winter Conference of Brain Research, Villars sur Ollon, Switzerland
EWCBR (Villars Sur Ollon, Switzerland)
2005/03/10 The cannabinoid and the vanilloid system in the basal ganglia. 25th European Winter Conference of Brain Research
EWCBR (Les Arcs, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09/01 - 2020/12/03 HYPOADENOSINERGIC PATHOLOGIES IN A RAT MODEL OF THE WILLIS-EKBOM DISEASE
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/04/01 - 2016/07/22 METABOLIC MODIFICATIONS ASSOCIATED WITH MEMORY DEFICIT
Supervisor of Ana Cristina Figueiredo de Lemos
 Biociências (PhD)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/01 - 2014/03/28 Insulin signalling depends on the endocannabinoid system in the brain
Supervisor of Carla de Silva-Santos
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/01 - 2013/09/04 The multifaceted role of the endocannabinoid system in cerebral glucose uptake
Supervisor of Bárbara S. Pinheiro
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008/09/01 - 2012/12/20 Presynaptic A2A adenosine receptors controls CB1 cannabinoid receptors-mediated effects at corticostriatal nerve terminals
Supervisor of Samira Cardoso Lopes (G) Ferreira
 Programme in Experimental Biology and Biomedicine (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/12 - 2011/06/27 Mapping the putative presynaptic neuromodulation of frontocortical serotonin release by the endocannabinoid system – toward the better understanding of psychiatric disorders
Supervisor of Filipe Alberto Marquês Teixeira
 Bioquímica
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011 - 2011 INVESTIGAÇÃO DA INTERAÇÃO ENTRE OS SISTEMAS ENDOCANABINÓIDE E CORTICOSTERÓIDE NO PROCESSO DE EXTINÇAO DE MEMÓRIAS AVERSIVAS EM RATOS
Co-supervisor
Universidade Federal de Santa Catarina, Brazil
2007/09/01 - 2008/06/17 CONTROL OF STRIATAL INPUT TERMINALS BY FATTY ACID DOPAMIDES IN RODENTS
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/09 - 2023/03/10 Attila Köfalvi established MCC-Medical Cannabis Coimbra (https://mcc.cnc.uc.pt/), and and chaired the International Scientific Congress entitled: “Clearing the smoke….: the importance of the endocannabinoid system in health and disease”. This congress provided an unbiased scientific view about the recent developments on medical cannabis. The aim of the congress is to foster scientific discussion about the topic among stakeholders including academic researchers, students, companies, regulatory entities, and health care professionals. (2023/03/09 - 2023/03/09)
Congress (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2010/05/07 Organizer of the 2010 Meeting of the Network of European Neuroscience Institutes Meeting venue: Auditorio da Reitoria, Universidade de Coimbra, Coimbra, Portugal Host Institute: Center for Neurosciences and Cell Biology (ENI Coimbra) Local Organizers: Inês Araújo, Attila Köfalvi, Rodrigo A. Cunha Participants: 68 participants from 10 countries. 1 plenary lecture, 18 lectures and 2 poster sessions encompassing 31 posters. (2010/05/05 - 2010/05/07)
Conference (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - 2006/07/11 Organizer and Chair of the Symposium S34: Targeting the endocannabinoid system in neurological and psychiatric disorders and pain at the 5th FENS Meeting in Vienna. Speakers: S34.1: Vincenzo Di Marzo (Pozzuoli, Italy) S34.2: David Baker (London, UK) S34.3: Beat Lutz (Mainz, Germany) S34.4: J. Michael Walker (Bloomington, USA). (2006/07/11 - 2006/07/11)
Symposium (President of the Organising Committee)
 Federation of European Neuroscience Societies, Belgium

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/09/17 Modulation of Subventricular Zone Postnatal Neurogenesis: Actions of Exercise-Regulated Neurotrophic Factors
(Thesis) Main arguer
 João Baptista Moreira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/02/25 Characterization of the affective behavioral effects of chronic adolescent exposure to the cannabinoid receptor agonist HU-210 in female rats
(Thesis) Main arguer
 Jorge Miguel Farinha Ferreira (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/02/08 Interference of Adenosinergic System in Endocannabinoid Signalling at the Hippocampus
(Thesis) Main arguer
 Joana Amorim Freire (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/01/19 Interaction between adenosine A2A receptors and cannabinoid CB1 receptors at the hippocampus: consequences for memory and plasticity
(Thesis) Main arguer
 Francisco Melo Mouro (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016/10/07 O papel do bolbo rostroventromedial na neuropatia diabética dolorosa
(Thesis) Main arguer
 Marta Alves da Silva (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2014/12/02 BRAIN-LIVER NITRIC OXIDE AXIS: A MAJOR REGULATORY PLAYER IN INSULIN CLEARANCE AND ACTION
Thesis Member
 Fátima Patrícia da Costa Oliveira Martins (PhD)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09/06 The Role of Astroglial Type 1 Cannabinoid Receptor in Memory Functions
(Thesis) Main arguer
 José Fernando Oliveira da Cruz (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/05/10 DEVELOPMENTAL DETERMINANTS OF SYNAPSE-SPECIFIC RETROGRADE SIGNALING IN CORTICAL NEURONAL NETWORKS
(Thesis) Main arguer
 Dobszay Márton Benedek (PhD)
Szegedi Tudomanyegyetem Termeszettudomanyi es Informatikai Kar, Hungary

Consulting

Activity description Institution / Organization
2018/03/06 - 2018/03/20 Reviewer of the bills PROJETO DE LEI N.º 726/XIII/3.ª (Bloco de Esquerda) and Projecto-lei n.º 727/XIII/3ª (Pessoas, Animais, Natureza) at the Portuguese Parliament, before Medical Cannabis legislation. The one-hour long discussion has been recorded. Assembleia da República, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2007 - 2017/12 O Sistema Endocanabinóide e o Cêrebro Impaired hippocampal glucose metabolism by decreased CB1 cannabinoid receptor-GSK3a signalling in TgApp mice The endocannabinoid system of the brain CB1 receptors at corticostriatal terminals – or is dyskinesia an inverse posychosis? Cannabinoids and the energy homeostasis Synaptic plasticity and the endocannabinoid system Introduction to the endocannabinoid system Mestrado em Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008/07/04 - 2017/04/04 Neurobiology of Reward and Drug Abuse, With Special Attention to Cannabis Neurofarmacologia (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/01/24 - 2016/11/21 The Endocannabinoid System in Physiology and Pathology Neuroenergêtica e a sua modulação pelo sistema endocanabinóide. Ciencias Biomédicas (Bacharelato) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2010/10/18 - 2010/10/22 Post-Graduate Course - Brain Repair: Tinkering with Brain Damage (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2013 - 2013 Reviewer for the Alz.org
Evaluator
 Alzheimer's Association, United States Alzheimer's Association
2012 - 2012 Grant evaluator
Evaluator
 Dutch Council for the Earth and Life sciences , Netherlands

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2018/05/24 Description of our work on the possible effects of the cannabinoid CB2 on cerebral glucose uptake in Alzheimer's disease Diário As Beiras
2018/05/23 Interview about the possible beneficial effects of medical cannabis in dementias SAPO
2018/01/12 Interviewed about the bills proposed by two parties, the PAN and the Bloco de Esquerda. Fact check. Canábis para fins medicinais: o que dizem os partidos é o que diz a ciência? Observador
2018/01/11 Interviewed about cannabis legalization and legislation. Observador
2017/02/02 Interview about medical cannabis at the 2017.02.02. issue of the periodical Visão (pages 52-55). Visão

Interview (tv / radio show)

Program Topic
2018/05/23 - 2018/05/23 News programme Our publication (Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.) gave headlines all over the news and I was interviewed for this.
2018/03/10 - 2018/03/10 A longer fact-check about cannabis - the medicine and the drug of abuse Brain awareness week, 2018
2009 - 2010 A two-hour interview about marijuana. Edrogas - youtube videos

Journal scientific committee

Journal title (ISSN) Publisher
2019/11/06 - Current Pharmacology Research & Perspectives (2052-1707) Wiley (John Wiley & Sons)
2015/09/27 - 2019 Neurochemistry International (0197-0186) Elsevier

Mentoring / Tutoring

Topic Student name
2017/04/06 - 2018/02/28 Possible preventive effect of anandamide on the changes in neuroplasticity and modulation of the endocannabinoid system induced by streptozotocin Daniel Moreira-Silva
2014/04/01 - 2014/08/31 Studying the role of insulin resistance in the onset of neuropsychiatric disorders with histochemical and biochemical tools Dr Shabnam Movassaghi
2010/02/26 - 2013/12/10 Functional interaction between presynaptic nicotinic and adenosine receptors in the control of dopamine release in the striatum Pedro Manuel Venâncio Garção
2007/06 - 2011/04 Retinal synaptic pathology type-1 diabetes Filipa I. Batista
2007/06 - 2011/04 Hippocampal synaptic pathology in type-1 diabetes Joana Margarida Gaspar
2009 - 2010 Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum Pablo Pandolfo
2009 - 2010 Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum Alexandre Rodrígues
2006 - 2009 Cross-talk mechanisms between adenosine and endocannabinoids Vasco MC Sousa
2008/04 - 2008/07 CAFFEINE, CANNABIS, CAPSAICIN – FROM PLANT TOXINS TO PRESYNAPTIC NEUROMODULATION Tonia Lomaglio
2007/04 - 2007/10 Brain glucose metabolism studies - co-orientation of a Brazilian post-doc . Gabriele Ghisleni
Distinctions

Other distinction

2009 ENI-Net Young Investigator
Europäisches Neurowissenschaftliches Institut Göttingen, Germany
2005 Achievement Award of the International Cannabinoid Research Society
The International Cannabinoid Research Society, United States
2004 IBRO Research Fellowship: Investigation of the function of P2 purinoceptors in the striatum – from basics to Parkinson’s disease.
International Brain Research Organization, France
2001 2001 Young Scientist Award of the Hungarian Pharmacological Society