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Identification

Personal identification

Full name
Telma Quintela

Author identifiers

Ciência ID
5714-670D-6E77
ORCID iD
0000-0001-5202-9858
Education
Degree Classification
2010/03/19
Concluded
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
"Regulation of Transthyretin Levels in Murine Choroid Plexus by Sex Steroid Hormones" (THESIS/DISSERTATION)
 Approved by unanimity
2004/07/19
Concluded
 Biologia (Licenciatura)
Major in Ramo de Formação Educacional
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 Final mark of 16 values out of 20
Affiliation

Science

Category
Host institution 		Employer
2018/09/03 - 2021/03/05 Contracted Researcher (Research) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/01 - Current Invited Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior, Portugal
2021/03/06 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal
2017/10/01 - 2018/07/31 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal
2011/10/01 - 2012/07/31 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal
2010/09/27 - 2011/07/31 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2011/08/01 - 2018/08/31 Research fellowship from FCT for Post-doctoral program Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/03/01 - 2015/06/01 Guest post-doc researcher in Neuroscience Department Karolinska Institutet, Sweden
2005/09/01 - 2009/09/01 Research fellowship from FCT for PhD program Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009/05/01 - 2009/07/31 Guest Researcher in IDIBAPS, Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain
2004/09/01 - 2005/09/01 Research volunteer Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2023 - Current ClockABC”, no âmbito do concurso Portugal e Noruega - Parcerias para a Inovação - FBR Open Call # 2
Ref FBR_OC2_78
Researcher
Ongoing
2021 - Current “Melatonina, Fisiologia e Fisiopatologia, estudos básicos e clínicos: caracterização da síndrome hipomelatonémica e o papel da reposição terapêutica com melatonina”
2019/24327-5
Researcher
Ongoing
2019 - 2020 Analysis of the regulation of drug uptake and detoxification systems in the blood-cerebrospinal fluid barrier - the role of sex hormones.
Sociedade Portuguesa Endocrinologia, Diabetes e Metabolismo
Principal investigator
Ongoing
2019 - 2020 “The choroid plexus as an alternative source of pituitary hormones: analysis of its regulatory mechanisms and secretory profiles”
N/A
Researcher
Concluded
2017 - 2020 Interdisciplinary Changes on Neurodegeneration-ICON
CENTRO-01-0145-FEDER-000013
Researcher
Concluded
2010 - 2014 Microarray based identification of estrogen and androgen responsive genes in rat choroid plexus
PTDC/SAU-NMC/114800/2009
Researcher
Universidade da Beira Interior, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2013 Identification of proteins differentially expressed in the cerebrospinal fluid of female and male rats subjected to gonadectomy
Grant agreement number 262067, funded by the European Union 7th Framework Programme
Principal investigator
Concluded
2005 - 2009 Regulation of human and mouse transthyretin levels in liver and choroid plexus by steroid hormones.
POCI/SAU-NEU/55380/2004
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
Outputs

Publications

Book chapter
  1. Furtado, André; Costa, Diana; Lemos, Manuel C.; Cavaco, J. Eduardo; Santos, Cecília R.A.; Quintela, Telma. "The impact of biological clock and sex hormones on the risk of disease". In Advances in Protein Chemistry and Structural Biology, 39-81. Elsevier, 2023.
    10.1016/bs.apcsb.2023.03.004
  2. Neves, Ana R.; Faria, Rúben; Albuquerque, Tânia; Quintela, Telma; Sousa, Ângela; Costa, Diana. "Future perspectives of biological macromolecules in biomedicine". In Biological Macromolecules, 607-632. Elsevier, 2022.
    10.1016/b978-0-323-85759-8.00026-9
  3. Albuquerque, Tânia; Neves, Ana Raquel; Faria, Rúben; Quintela, Telma; Costa, Diana. "Chronobiology and Nanotechnology for Personalized Cancer Therapy". In Cancer Nanotechnology, 205-227. Springer International Publishing, 2022.
    10.1007/978-3-031-17831-3_7
  4. Gonçalves, Isabel; Quintela, Telma; Duarte, Ana Catarina; Hubbard, Peter; Baltazar, Graça; Schwerk, Christian; Belin, Andrea Carmine; Tomás, Joana; Santos, Cecília Reis A.. "Experimental Tools to Study the Regulation and Function of the Choroid Plexus". In Blood-Brain Barrier, 205-230. Springer New York, 2018.
    Published • 10.1007/978-1-4939-8946-1_13
Journal article
  1. Rafael Mineiro; Tânia Albuquerque; Ana Raquel Neves; Cecília R. A. Santos; Diana Costa; Telma Quintela. "The Role of Biological Rhythms in New Drug Formulations to Cross the Brain Barriers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612541.
    10.3390/ijms241612541
  2. Tânia Albuquerque; Ana Raquel Neves; Milan Paul; Swati Biswas; Elena Vuelta; Ignacio García-Tuñón; Manuel Sánchez-Martin; Telma Quintela; Diana Costa. "A Potential Effect of Circadian Rhythm in the Delivery/Therapeutic Performance of Paclitaxel–Dendrimer Nanosystems". Journal of Functional Biomaterials (2023): https://doi.org/10.3390/jfb14070362.
    10.3390/jfb14070362
  3. Rafael Mineiro; Cecília Santos; Isabel Gonçalves; Manuel Lemos; José Eduardo B. Cavaco; Telma Quintela. "Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes". Journal of Physiology and Biochemistry (2023): https://doi.org/10.1007/s13105-023-00957-1.
    10.1007/s13105-023-00957-1
  4. Santos, Cecília R. A.; Cipolla-Neto, José; Krohn, Markus; Gonçalves, Isabel; Quintela, Telma. "Editorial: Crossing brain barriers in health and disease: Impact of circadian rhythms". Frontiers in Neuroscience 17 (2023): http://dx.doi.org/10.3389/fnins.2023.1176084.
    10.3389/fnins.2023.1176084
  5. Furtado, André; Esgalhado, André J.; Duarte, Ana C.; Costa, Ana R.; Costa-Brito, Ana R.; Carro, Eva; Ishikawa, Hiroshi; et al. "Circadian rhythmicity of amyloid-beta-related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model". Journal of Neuroscience Research 101 4 (2022): 524-540. http://dx.doi.org/10.1002/jnr.25164.
    10.1002/jnr.25164
  6. Neves, Ana R.; Albuquerque, Tânia; Quintela, Telma; Costa, Diana. "Circadian rhythm and disease: Relationship, new insights, and future perspectives". Journal of Cellular Physiology 237 8 (2022): 3239-3256. http://dx.doi.org/10.1002/jcp.30815.
    10.1002/jcp.30815
  7. Duarte, Ana Catarina; Costa, Ana Raquel; Gonçalves, Isabel; Quintela, Telma; Preissner, Robert; Santos, Cecília R.A.. "The druggability of bitter taste receptors for the treatment of neurodegenerative disorders". Biochemical Pharmacology 197 (2022): 114915. http://dx.doi.org/10.1016/j.bcp.2022.114915.
    10.1016/j.bcp.2022.114915
  8. Furtado, André; Mineiro, Rafael; Duarte, Ana Catarina; Gonçalves, Isabel; Santos, Cecília R.; Quintela, Telma. "The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate". International Journal of Molecular Sciences 23 5 (2022): 2443. http://dx.doi.org/10.3390/ijms23052443.
    10.3390/ijms23052443
  9. Albuquerque, Tânia; Neves, Ana R.; Quintela, Telma; Costa, Diana. "The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector". Polymers 14 4 (2022): 681. http://dx.doi.org/10.3390/polym14040681.
    10.3390/polym14040681
  10. Quintela, Telma; Furtado, André; Duarte, Ana C.; Gonçalves, Isabel; Myung, Jihwan; Santos, Cecília R.A.. "The role of circadian rhythm in choroid plexus functions". Progress in Neurobiology 205 (2021): 102129. http://dx.doi.org/10.1016/j.pneurobio.2021.102129.
    10.1016/j.pneurobio.2021.102129
  11. Albuquerque, Tânia; Neves, Ana R.; Quintela, Telma; Costa, Diana. "Exploring the link between chronobiology and drug delivery: effects on cancer therapy". Journal of Molecular Medicine 99 10 (2021): 1349-1371. http://dx.doi.org/10.1007/s00109-021-02106-x.
    10.1007/s00109-021-02106-x
  12. Cipolla-Neto, José; Amaral, Fernanda Gaspar; Soares, Jr, José Maria; Gallo, Camila Congentino; Furtado, André; Cavaco, José Eduardo; Gonçalves, Isabel; Santos, Cecília Reis Alves; Quintela, Telma. "The Crosstalk between Melatonin and Sex Steroid Hormones". Neuroendocrinology 112 2 (2021): 115-129. http://dx.doi.org/10.1159/000516148.
    10.1159/000516148
  13. Quintela, T. "Familial neurohypophyseal diabetes insipidus: clinical, genetic and functional studies of novel mutations in the arginine vasopressin gene.". Pituitary (2021): https://doi.org/10.1007/s11102-020-01119-y.
    10.1007/s11102-020-01119-y
  14. Quintela, T. "The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain.". Molecular neurobiology (2021): https://doi.org/10.1007/s12035-020-02267-9.
    10.1007/s12035-020-02267-9
  15. Quintela, T. "Maternal pineal melatonin in gestation and lactation physiology, and in fetal development and programming.". General and comparative endocrinology (2020): https://doi.org/10.1016/j.ygcen.2020.113633.
    10.1016/j.ygcen.2020.113633
  16. Quintela, T. "Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus.". International journal of molecular sciences (2020): https://europepmc.org/articles/PMC7554684.
    10.3390/ijms21186813
  17. Furtado, André; Astaburuaga, Rosario; Costa, Ana; Duarte, Ana C.; Gonçalves, Isabel; Cipolla-Neto, José; Lemos, Manuel C.; et al. "The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer’s Disease". Journal of Alzheimer's Disease 77 2 (2020): 795-806. http://dx.doi.org/10.3233/jad-200331.
    10.3233/jad-200331
  18. Quintela, T. "The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier". Biochemical Pharmacology (2020): http://dx.doi.org/10.1016/j.bcp.2020.113953.
    10.1016/j.bcp.2020.113953
  19. Quintela, T. "Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier". Biochemical Pharmacology (2020): http://dx.doi.org/10.1016/j.bcp.2020.113954.
    10.1016/j.bcp.2020.113954
  20. Daniela Talhada; Ana Raquel Costa-Brito; Ana Catarina Duarte; Ana Raquel Costa; Telma Quintela; Joana Tomás; Isabel Gonçalves; Cecília Reis Alves Santos. "The choroid plexus: Simple structure, complex functions". Journal of Neuroscience Research (2019): https://doi.org/10.1002/jnr.24571.
    10.1002/jnr.24571
  21. Santos, C.R.A.; Duarte, A.C.; Costa, A.R.; Tomás, J.; Quintela, T.; Gonçalves, I.. "The senses of the choroid plexus". Progress in Neurobiology 182 (2019): 101680. http://dx.doi.org/10.1016/j.pneurobio.2019.101680.
    Published • 10.1016/j.pneurobio.2019.101680
  22. Joana Tomás; Cecília R.A. Santos; Ana C. Duarte; Maria Maltez; Telma Quintela; Manuel C. Lemos; Isabel Gonçalves. "Bitter taste signaling mediated by Tas2r144 is down-regulated by 17ß-estradiol and progesterone in the rat choroid plexus". Molecular and Cellular Endocrinology 495 (2019): 110521-110521. https://doi.org/10.1016/j.mce.2019.110521.
    10.1016/j.mce.2019.110521
  23. Telma Quintela; Isabel Gonçalves; Marco Silva; Ana C. Duarte; Paula Guedes; Késsia Andrade; Flávia Freitas; et al. "Choroid plexus is an additional source of melatonin in the brain". Journal of Pineal Research 65 4 (2018): e12528-e12528. https://doi.org/10.1111/jpi.12528.
    10.1111/jpi.12528
  24. Telma Quintela; Tânia Albuquerque; Gabriella Lundkvist; Andrea Carmine Belin; Daniela Talhada; Isabel Gonçalves; Eva Carro; Cecília R.A. Santos. "The choroid plexus harbors a circadian oscillator modulated by estrogens". Chronobiology International 35 2 (2018): 270-279. https://doi.org/10.1080/07420528.2017.1400978.
    10.1080/07420528.2017.1400978
  25. Josué Carvalho; Telma Quintela; Nassima M. Gueddouda; Anne Bourdoncle; Jean-Louis Mergny; Gilmar F. Salgado; João A. Queiroz; Carla Cruz. "Phenanthroline polyazamacrocycles as G-quadruplex DNA binders". Organic & Biomolecular Chemistry 16 15 (2018): 2776-2786. https://doi.org/10.1039/C8OB00247A.
    10.1039/C8OB00247A
  26. Santos, C.R.A.; Duarte, A.C.; Quintela, T.; Tomás, J.; Albuquerque, T.; Marques, F.; Palha, J.A.; Gonçalves, I.. "The choroid plexus as a sex hormone target: Functional implications". Frontiers in Neuroendocrinology 44 (2017): 103-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008324860&partnerID=MN8TOARS.
    10.1016/j.yfrne.2016.12.002
  27. Duarte, A.C.; Hrynchak, M.V.; Gonçalves, I.; Quintela, T.; Santos, C.R.A.. "Sex Hormone Decline and Amyloid ß Synthesis, Transport and Clearance in the Brain". Journal of Neuroendocrinology 28 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997109193&partnerID=MN8TOARS.
    10.1111/jne.12432
  28. Costa, A.R.; Marcelino, H.; Gon�alves, I.; Quintela, T.; Tom�s, J.; Duarte, A.C.; Fonseca, A.M.; Santos, C.R.A.. "Sex Hormones Protect Against Amyloid-ß Induced Oxidative Stress in the Choroid Plexus Cell Line Z310". Journal of Neuroendocrinology 28 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84986557055&partnerID=MN8TOARS.
    10.1111/jne.12404
  29. Gonçalves, I.; Hubbard, P.C.; Tomás, J.; Quintela, T.; Tavares, G.; Caria, S.; Barreiros, D.; Santos, C.R.A.. "Smelling the cerebrospinal fluid: Olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus". FEBS Journal 283 9 (2016): 1748-1766. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962788147&partnerID=MN8TOARS.
    10.1111/febs.13700
  30. Quintela, T.; Marcelino, H.; Deery, M.J.; Feret, R.; Howard, J.; Lilley, K.S.; Albuquerque, T.; et al. "Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis". Journal of Neuroendocrinology 28 1 (2016): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956911885&partnerID=MN8TOARS.
    10.1111/jne.12340
  31. Tomás, J.; Santos, C.R.A.; Quintela, T.; Gonçalves, I.. ""Tasting" the cerebrospinal fluid: Another function of the choroid plexus?". Neuroscience 320 (2016): 160-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958260325&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2016.01.057
  32. Quintela, T.; Sousa, C.; Patriarca, F.M.; Gonçalves, I.; Santos, C.R.A.. "Gender associated circadian oscillations of the clock genes in rat choroid plexus". Brain Structure and Function 220 3 (2015): 1251-1262. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893837556&partnerID=MN8TOARS.
    10.1007/s00429-014-0720-1
  33. Quintela, T.; Marcelino, H.; Gonçalves, I.; Patriarca, F.M.; Santos, C.R.A.. "Gene Expression Profiling in the Hippocampus of Orchidectomized Rats". Journal of Molecular Neuroscience 55 1 (2014): 198-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920841664&partnerID=MN8TOARS.
    10.1007/s12031-014-0304-9
  34. Quintela, T.; Gonçalves, I.; Carreto, L.C.; Santos, M.A.S.; Marcelino, H.; Patriarca, F.M.; Santos, C.R.A.. "Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876025530&partnerID=MN8TOARS.
    10.1371/journal.pone.0060199
  35. Santos, C.R.A.; Martinho, A.; Quintela, T.; Gonçalves, I.. "Neuroprotective and neuroregenerative properties of metallothioneins". IUBMB Life 64 2 (2012): 126-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855863743&partnerID=MN8TOARS.
    10.1002/iub.585
  36. Quintela, T.; Gonçalves, I.; Martinho, A.; Alves, C.H.; Saraiva, M.J.; Rocha, P.; Santos, C.R.A.. "Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor". Journal of Molecular Neuroscience 44 3 (2011): 152-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054082420&partnerID=MN8TOARS.
    10.1007/s12031-010-9398-x
  37. Martinho, A.; Gonçalves, I.; Cardoso, I.; Almeida, M.R.; Quintela, T.; Saraiva, M.J.; Santos, C.R.A.. "Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin". FEBS Journal 277 16 (2010): 3427-3436. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2010.07749.x
  38. Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A.. "Androgen receptor is expressed in murine choroid plexus and downregulated by 5a-Dihydrotestosterone in male and female mice". Journal of Molecular Neuroscience 38 1 (2009): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949213641&partnerID=MN8TOARS.
    10.1007/s12031-008-9157-4
  39. Quintela, T.; Gonçalves, I.; Baltazar, G.; Alves, C.H.; Saraiva, M.J.; Santos, C.R.A.. "17ß-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway". Cellular and Molecular Neurobiology 29 4 (2009): 475-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=MN8TOARS.
    10.1007/s10571-008-9339-1
  40. Gonçalves, I.; Quintela, T.; Baltazar, G.; Almeida, M.R.; Saraiva, M.J.M.; Santos, C.R.. "Transthyretin interacts with metallothionein 2". Biochemistry 47 8 (2008): 2244-2251. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749120520&partnerID=MN8TOARS.
    10.1021/bi7016377
  41. Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A.. "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317 1-2 (2008): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS.
    10.1007/s11010-008-9841-2
  42. Quintela, T.; Alves, C.H.; Gonçalves, I.; Baltazar, G.; Saraiva, M.J.; Santos, C.R.A.. "5a-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway". Brain Research 1229 (2008): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=MN8TOARS.
    10.1016/j.brainres.2008.06.095
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 Amyloid-ß-Induced Alterations in the Choroid Plexus Circadian Clock 30th Conference of the International Society for Chronobiology
International Society for Chronobiology (Varsóvia, Poland)
2016 Rock around the choroid plexus clock 17th International Congress of Endocrinology and 15th Annual Meeting of Chinese Society of Endocrinology
Chinese Society of Endocrinology (Pequim, China)
2015 Rock around the choroid plexus clock 1st Congress in Health Sciences Research, Towards Innovation and Entrepreneuship. Trends in Endocrinology and Neurosciences
(Covilhã, Portugal)
2014 Synthesis of testosterone by choroid plexus 16th Congress of the European Neuroendocrine Association
European Neuroendocrine Association (Sofia, Bulgaria)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - Current Analysis of the regulation of drug uptake and detoxification systems in the blood-cerebrospinal fluid barrier: the role of sex hormones and circadian rhythm
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2019 - Current Circadian Modulation of Abeta scavengers at the blood-cerebrospinal fluid barrier
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2019 - Current Cancer Chronotherapy: A role for the circadian clock in the therapeutic effect mediated by Drug/Gene co-delivery
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2018 - 2019 Disruption of the Choroid Plexus Circadian Rhythm’s in Alzheimer’s Disease
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Síntese de Melatonina no plexo coroide
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Regulação das proteínas responsáveis pela degradação do péptido de amiloide beta no plexo coroide
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 Circadian expression of steroidogenic cytochromes P450 involved in the metabolism of xenobiotics in the rat choroid plexus
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 Regulation of circadian clock genes Per1 and Per2 by estradiol in rat choroid plexus epithelial cells
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2013 - 2014 O ritmo circadiano no plexo coroide de rato
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2012 - 2013 Plexo coroide – local de síntese de hormonas esteróides?
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2018 Organização e participação na Semana Internacional do Cérebro. Iniciativa anual que tem como objetivo a divulgação junto do público dos progressos e benefícios da investigação científica na área do cérebro. (2018 - 2018)
Other (Member of the Organising Committee)
2015 - 2015 Organização da Semana Internacional do Cérebro. Iniciativa anual que tem como objetivo a divulgação junto do público dos progressos e benefícios da investigação científica na área do cérebro. (2015 - 2015)
Other (Member of the Organising Committee)
2015 - 2015 Organização da Semana da Ciência e Tecnologia. Neste contexto organizou palestras e atividades lúdicas em que foram aprofundados conhecimentos sobre o funcionamento do cérebro e a relação com as doenças neurodegenerativas. (2015 - 2015)
Workshop (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2012 - 2012 Escola de Verão em Endocrinologia
Other
 ESE Bregenz Summer School on Endocrinology
2011 - 2011 Curso Comportamento Animal
Other
 PhenoMaster Comportamento Operante para 4 ratos
Universidade da Beira Interior, Portugal
2011 - 2011 Curso de Eletroforese Bidimencional 2D-PAGE
Workshop
 Training Course in Differential Gel Electrophoresis - Ettan DIGE
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2011 Curso avançado em análise proteómica
Workshop
 EMBL Advanced Course: Proteome Analysis by Mass Spectrometry – From Samples to Data Analysis
European Molecular Biology Laboratory, Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2017 Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration
(Thesis) Main arguer
 Marta Cristina Valério Afonso (Master)
Universidade da Beira Interior, Portugal
2013 Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model of Parkinson´s disease
(Thesis) Main arguer
 Marta Raquel Carrola Esteves (Master)
Universidade da Beira Interior, Portugal
2012 Catacterização das alterações cognitivas ao longo do envelhecimento em mulheres: correlação com os níveis de estradiol?
(Thesis) Main arguer
 Marta Sofia Jacinto Ribeiro (Master)
Universidade da Beira Interior, Portugal
2012 Expressão de GDNF em células estriatais: efeito de fatores solúveis libertados por células do mesencéfalo ventral após lesão dopaminérgica
(Thesis) Main arguer
 Susana Martins Gama (Master)
Universidade da Beira Interior, Portugal
2011 Efeito do 17-beta-estradiol na expressão da transtirretina e da metalotioneína-1/2 numa linha celular de plexo coróideu de rato
(Thesis) Main arguer
 Marta Isabel Nunes Costa (Master)
Universidade da Beira Interior, Portugal

Conference scientific committee

Conference name Conference host
2019 - 2019 III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer Covilhã, Portugal
2015 - 2015 1st Congress in Health Sciences Research, Towards Innovation and Entrepreneuship. Trends in Endocrinology and Neurosciences Covilhã, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017 - 2018 Unidade Curricular de Biologia Molecular Aplicada Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2012 - 2013 Anatomia e Fisiologia II Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2012 - 2013 Corpo Humano: dos Sistemas às Moléculas I Medicina Universidade da Beira Interior, Portugal
2010 - 2011 Anatomia e Fisiologia II Ciências Básicas Farmacêuticas (Licenciatura) Universidade da Beira Interior, Portugal
2010 - 2011 Corpo Humano: dos Sistemas às Moléculas II Medicina Universidade da Beira Interior, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Journal of Pineal Research (1600-079X) Wiley (Blackwell Publishing)
2019 - Current Melatonin Research (2641-0281) ST Bio-life
2019 - Current Neuroscience Letters (0304-3940) Elsevier
2017 - Current International Journal of Nanomedicine (1178-2013) Dove Medical Press
Distinctions

Other distinction

2019 Travel Grant from the International Brain Research Organization (IBRO)
2016 Travel Grant from the International Society of Endocrinology
2015 Travel Grant from the International Brain Research Organization – IBRO
International Brain Research Organization, France
2014 Travel Grant from the European Neuroendocrine Association
2012 Travel Grant from the European Society of Endocrinology
2011 Travel Grant from European Molecular Biology Laboratory