Ana Filipa Soares Pires (571B-65F0-58B3)

Curriculum Vitae

Ana Filipa Soares Pires

Filipa Pires (FP) obtained her MSc in Bioengineering and Nanosystems from IST in 2013 and her PhD in Biophysics at FCT-UNL in 2019. In last years, her research encompasses the design of responsive biomaterials that can change their properties or behavior in response to external stimuli, such as electricity and light to guide the cell response (proliferation, differentiation, migration) in tissue regeneration. She also has expertise on designing nanocarriers as liposomes, hydrogels, or nanocapsules to encapsulate antioxidants (catechins, curcumin, naringin, ferulic acid), anticoagulants (heparin) and anticancer drugs for improving the pharmacokinetic profile and therapeutic efficacy. In 2020, as Junior Researcher (BeLive, PTDC/EMD-EMD/30828/2017), she had the opportunity to specialize on developing magnetic scaffolds to stimulate angiogenesis for heart applications. She co-supervised two MSc students who functionalized the magnetic scaffolds with nanocarriers (nanoparticles and liposomes) containing anticoagulants and anti-inflammatory drugs aimed to increase therapeutic angiogenesis in the injured heart. More recently, as a Junior Researcher (RESORB - an EIC PathFinder), she embarked on a new international team challenge by creating the first bioresorbable chemical sensor for in vivo real-time monitoring of the chemotherapy agent doxorubicin. Summing up, her research focuses on developing smart responsive materials to control drug release profile and/or to manipulate cell response to significantly improve patient outcomes by enhancing the effectiveness of drug therapies and accelerating tissue regeneration. She is co-author of 9 articles (7 as first-author) published in Q1 international peer-reviewed journals, 6 book chapters (5 as first author), 9 conference papers with peer-reviewed (4 as first-author), with a total of 387 citations and an h-index of 7. I have a total of 15 abstracts in national and international conferences, with 9 oral presentations. Aside from her research work, she has also been involved in various academic and scientific event organizations. As a dynamic person, she was member of the organization committee of the 15th International Conference on Computational Intelligence methods for Bioinformatics /Biostatistics and of the EUSpec COST ACTION MP1306-Modern Tools for Spectroscopy on Advanced Materials held at FCT/UNL. She also got involved in teaching Physics II and Physics III at FCT/UNL and was guest-editor with the topic “"Radiation-Sensitive Bio Platforms for Cancer Diagnosis and Therapy: Current Status and Future Perspectives" in journal Radiation.

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Identification

Personal identification

Full name: Ana Filipa Soares Pires
Gender: Female

Citation names

Filipa Pires

Author identifiers

Ciência ID: 571B-65F0-58B3
ORCID iD: 0000-0002-0113-3003

Email addresses

ana.pires@lx.it.pt (Professional)
ana.pires@lx.it.pt (Professional)

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2015/04/01 - 2019/10/28 Concluded	Biofísica e Bioquímica das Radiações (Doutoramento) Major in Biofísica Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Liposomes encapsulating catechins: a biophysical approach for skin cancer therapy." (THESIS/DISSERTATION)	Aprovado por Unanimidade

Affiliation

Science

	Category Host institution	Employer
2022/08/01 - Current	Contracted Researcher (Research)	Instituto de Telecomunicações, Portugal
	Instituto de Telecomunicações, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2018/03/01 - 2018/06/30	Assistant (University Teacher)	Universidade Nova de Lisboa Departamento de Física, Portugal

Others

	Category Host institution	Employer
2020/01/01 - 2022/06	Investigador Contratado (Investigação)	Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
	Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2017/09 - 2017/12	Investigador Visitante	Universidade de São Paulo Instituto de Física de São Carlos, Brazil
	Universidade de São Paulo Instituto de Física de São Carlos, Brazil
2017/04/23 - 2017/05/01	Investigador Visitante	Aarhus Universitet, Denmark
	Aarhus Universitet, Denmark
2016/10/10 - 2016/10/28	Investigador Visitante	Universidade de São Paulo Instituto de Física de São Carlos, Brazil
	Universidade de São Paulo Instituto de Física de São Carlos, Brazil
2015/01/01 - 2015/03/01	Investigador	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/06/01 - 2014/12/01	Investigador	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal

Projects

Grant

	Designation	Funders
2020 - 2022/09/30	BeLive: Magnetic-responsive perfusable 3D tissue scaffolds for vascularization studies PTDC/EMD-EMD/30828/2017 Post-doc Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2015/04 - 2019/10	Liposomes encapsulating catechins: a way to cancer therapy PD/BD/106036/2015 PhD Student Fellow	Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior Concluded
2016/01 - 2018/12	Development of Nanostrutures for Detection of Triclosan Traces on Aquatic Environments grant.Provided by PTCRIS: 139534	Fundação para a Ciência e a Tecnologia
2014/11 - 2014/12	Scanning Tunneling Microscopy Image Processing Tools PEst-OE/EEI/LA0008/2013 Research Fellow	Instituto de Telecomunicações

Contract

	Designation	Funders
2022/08/01 - Current	RESORB: On-Demand Bioresorbable OptoElectronic System for In-Vivo and In-Situ Monitoring of Chemotherapeutic Drugs 101046946 Post-doc	EU Framework Programme for Research and Innovation ICT Leadership in Enabling and Industrial Technologies Ongoing
2021/01/01 - 2023/12/31	Institute of Telecommunications LA/P/0109/2020 10.54499/LA/P/0109/2020 UID/EEA/50008/2019 Instituto de Telecomunicações Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDP/04378/2020 10.54499/UIDP/04378/2020 UIDB/04378/2020 10.54499/UIDB/04378/2020 Universidade do Porto, Portugal Universidade Nova de Lisboa, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Instituto de Telecomunicações UIDB/EEA/50008/2020 Instituto de Telecomunicações Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centro de Física e Investigação Tecnológica UID/FIS/00068/2019 Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Universidade Nova de Lisboa Centro de Física e Investigação Tecnológica, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos UID/QUI/50006/2019 LA/P/0008/2020 10.54499/LA/P/0008/2020 Universidade do Porto Faculdade de Ciências, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa, Portugal Universidade de Aveiro, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade de Évora, Portugal Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal Universidade de Lisboa Instituto Dom Luiz, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Unidade de Ciências Biomoleculares Aplicadas UID/Multi/04378/2019 154717UID Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/04/24 - 2017/04/30	Influence of UV irradiation on EGCG-Liposome Suspensions: effect on structure, encapsulation and stability ISA-17-1052 Researcher

Outputs

Publications

Book chapter	Gonçalo Magalhães-Mota; Filipa Pires; Paulo A. Ribeiro; Maria Raposo. "Detection of Triclosan Dioxins After UV Irradiation – A Preliminar Study". 326-332. Springer International Publishing, 2020. 10.1007/978-3-030-34585-3_30 Thais P. Pivetta; Filipa Pires; Maria Raposo. "Effect of EGCG on the DNA in Presence of UV Radiation". 303-308. Springer International Publishing, 2020. 10.1007/978-3-030-34585-3_27 Filipa Pires; Bárbara Rodrigues; Gonçalo Magalhães-Mota; Paulo A. Ribeiro; Maria Raposo. "Effect of Epigallocatechin-3-gallate on DMPC Oxidation Revealed by Infrared Spectroscopy". 295-302. Springer International Publishing, 2020. 10.1007/978-3-030-34585-3_26 Filipa Pires; Gonçalo Magalhães-Mota; Maria Raposo. "Dietary Polyphenols Working as Epigenetics Modulators: Impact on Cancer Prevention". In Advances in Medicine e Biology, edited by Leon V. Berhardt. NOVAScience Publishers, 2018. Published Pires, Ana; Filipa Pires. "Imaging of liposomal drug delivery systems by atomic force microscopy". In Microscopy and imaging science: practical approaches to applied research and education, edited by A. Méndez Vilas, 183-194. Formatex Research Center, 2017. Published Filipa Pires; Gonçalo Magalhães-Mota; P.A.Ribeiro; Maria Raposo. "Effect of UV radiation on DPPG and DMPC liposomes in presence of catechin molecules". edited by Bracciali, A., Caravagna, G., Gilbert, D., Tagliaferri, R.. 2017. https://doi.org/10.1007/978-3-319-67834-4_14
Conference abstract	C.J. Conceição; Thaís Pivetta; Filipa Pires; P. A. Ribeiro; Maria Raposo. "DNA Repair Inhibitors – Strategic Platform for Cancer Radiotherapy”". Paper presented in NOVA BIOPHYSICA, lisboa, 2019. Published Filipa Pires; Bárbara Rodrigues; Miguel Machuqueiro; Maria Raposo. "Encapsulation of catechin EGCG in the liposome: analysis of molecular dynamics and UV radiation interactions". Paper presented in 2nd Nova Biomedical Engineering Workshop, Caparica, 2017. Published Filipa Pires; Maria Raposo. "Liposomes encapsulating catechins: antioxidant network to fight cancer progression". Paper presented in 11th International Conference on Surfaces, Coatings and Nanostructured Materials, Aveiro, 2016. Published
Conference paper	Thais P. Pivetta; Conceição, C.J.F.; Pires, Filipa; Ribeiro, P. A.; Raposo, M.. "Liposomes as a drug delivery system for a novel class of anticarcinogenic agents". Paper presented in Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB) Proceedings, Bergamo, 2019. Telma S. Marques; Filipa Pires; Gonçalo Magalhães-Mota; P.A.Ribeiro; Maria Raposo. "Development of a DNA Biodosimeter for UV radiation". Paper presented in PHOTOPTICS 2018 - Proceedings of the 6th International Conference on Photonics, Optics and Laser Technology, Funchal, 2018. 10.5220/0006732003280333 Filipa Pires. "Artificial nanosystems to decode natural antioxidants–cellular membranes interactions". Paper presented in Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB) Proceedings, Stirling, 2016. Filipa Pires; Margarida Coelho; P.A.Ribeiro; Maria Raposo. "Methylene blue: A Trendy Photosensitizer in Medicine and in Solar-Energy Conversion Systems". Paper presented in PHOTOPTICS 2016 - Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology, Roma, 2016. Published • 10.5220/0005843303790383 Filipa Pires; Mónica Araújo; A. M. Bragança; Luísa Mendonça; Jorge Morgado; Ferreira, Quirina. "Nanostructured drug delivery systems for brimonidine controlled release.". 2016. 10.1007/978-3-319-67834-4
Conference poster	Filipa Pires; N.C. Jones; S.V. Hoffmann; T. Demeter; Maria Raposo. "Analysis of antioxidant activity of EGCG in phospholipids by VUV spectroscopy.". Paper presented in 1st NOVA Biophysica Conference, 2019. Jeniffer F. Santos; Filipa Pires; Diogo B Bitoque; Gabriela A. Silva; Alexandre Marletta; Paulo A. Ribeiro; Silva, J.C.; Maria Raposo; Viviane Abreu Nunes Cerqueira Dantas. "Antioxidant effect of EGCG-liposome functionalized electrospun nanofibers". 2019. Filipa Pires; Vananélia P. N. Geraldo; Alexandre Marletta; Osvaldo N. Oliveira Jr.; Maria Raposo. "Interaction of green tea catechins with model DPPG membranes". Paper presented in 2nd Nova biomedical engineering workshop, 2017. Bárbara Rodrigues; Filipa Pires; Miguel Machuqueiro; Maria Raposo. "Encapsulation of Catechin EGCG in the Liposome: Analysis of Molecular Dynamics and UV Radiation Interactions.". Paper presented in 2nd Nova biomedical engineering workshop, 2017. Filipa Pires. "Liposomes encapsulating catechins: a molecular walk against cancer.". Paper presented in Molecules in Motion Training School, 2016.
Journal article	Filipa Pires; João Carlos Silva; Frederico Castelo Ferreira; Carla A. M. Portugal. "Heparinized Acellular Hydrogels for Magnetically Induced Wound Healing Applications". ACS Applied Materials & Interfaces (2024): https://doi.org/10.1021/acsami.3c18877. 10.1021/acsami.3c18877 Luís Pereira; Frederico Castelo Ferreira; Ana Filipa Soares Pires; Carla A. M. Portugal. "Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics". Membranes (2023): https://www.mdpi.com/2077-0375/13/7/674. 10.3390/membranes13070674 Filipa Pires; Gonçalo Magalhães-Mota; Vananélia P. Geraldo; Paulo A. Ribeiro; Osvaldo N. Oliveira Jr.; Maria Raposo. "The impact of blue light in monolayers representing tumorigenic and nontumorigenic cell membranes containing epigallocatechin-3-gallate". Colloids and Surfaces B: Biointerfaces (2020): 10.1016/j.colsurfb.2020.111129 Filipa Pires; Jeniffer Farias Santos; Diogo Bitoque; Gabriela Araújo Silva; Alexandre Marletta; Viviane Abreu Nunes; Paulo A. Ribeiro; Jorge Carvalho Silva; Maria Raposo. "Polycaprolactone/Gelatin Nanofiber Membranes Containing EGCG-Loaded Liposomes and Their Potential Use for Skin Regeneration". ACS Applied Bio Materials (2019): 10.1021/acsabm.9b00524 Filipa Pires; Vananélia P. N. Geraldo; Bárbara Rodrigues; António de Granada-Flor; Rodrigo F. M. de Almeida; Osvaldo N. Oliveira Jr.; Bruno L. Victor; Miguel Machuqueiro; Maria Raposo. "Evaluation of EGCG Loading Capacity in DMPC Membranes". Langmuir (2019): 10.1021/acs.langmuir.9b00372 Filipa Pires; Vananélia P. N. Geraldo; Andrea Antunes; Alexandre Marletta; Osvaldo N. Oliveira Jr.; Maria Raposo. "Effect of blue light irradiation on the stability of phospholipid molecules in the presence of epigallocatechin-3-gallate". Colloids and Surfaces B: Biointerfaces (2019): 10.1016/j.colsurfb.2019.01.042 Filipa Pires; Vananélia P. N. Geraldo; Andrea Antunes; Alexandre Marletta; Osvaldo N. Oliveira Jr.; Maria Raposo. "On the role of epigallocatechin-3-gallate in protecting phospholipid molecules against UV irradiation". Colloids and Surfaces B: Biointerfaces (2019): 10.1016/j.colsurfb.2018.09.065 Inês Marques; Gonçalo Magalhães-Mota; Filipa Pires; Susana Sério; P. A. Ribeiro; Maria Raposo. "Detection of traces of triclosan in water". Applied Surface Science (2017): https://doi.org/10.1016/j.apsusc.2016.12.170 Filipa Pires; Ferreira, Quirina; Rodrigues, Carlos A.V.; Jorge Morgado; Frederico Castelo Ferreira. "Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: Expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering". Biochimica et Biophysica Acta (BBA)-General Subjects (2015): https://doi.org/10.1016/j.bbagen.2015.01.020

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/11/07	Biodegradable Light-Emitting Diodes (LED’s) for biophotonic applications	Nano&Bio&Med (Barcelona, Spain)
2023/05	Smart Materials in drug delivery and regenerative medicine	Seminar: Department of Physics FCT-UNL
2018/09/06	Effect of epigallocatechin-3-gallate on DMPC oxidation revealed by infrared spectroscopy	Computational Intelligence Methods for Bioinformatics and Biostatistics Universidade Nova Lisboa, FCT. (Caparica, Portugal)
2018/02/21	Investigation of the protective role of EGCG against oxidative stress induced by ultraviolet radiation by spectroscopic techniques	EUSpec COST Action MP1306 "Final Whole Action Meeting" Universidade Nova Lisboa, FCT. (Caparica, Portugal)
2017/05/14	Biomimetic systems to reveal the action mode of Epigallocatechin-3-gallate in lipid membrane.	19th International Conference on Nano and Materials Engineering (amesterdão, Netherlands)
2016/05/19	Liposomes encapsulating catechins: an herbal strategy to defeating cancer at the nanoscale.	3rd USA International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT-USA) University of Texas (Arlington, United States)
2016/03/22	Catechins: natural antioxidants against oxidative deterioration of DNA.	2nd Workshop in Heavy Metals: from the environment to the man Universidade Nova Lisboa, FCT. (Caparica, Portugal)
2016/02/17	Catechins: a powerful weapon against oxidative stress and DNA lesions.	Nanoscience and Nanotecnhology International Conference (NanoPT) (Braga, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021 - Current	Design of heparin-biomimetic hydrogels for controlled released of pro-angiogenic agents Co-supervisor	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/03 - 2023/12	Development of green Organic Light-Emitting Diodes using biocompatible and biodegradable electrodes Co-supervisor	Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/10 - 2022/10	Development of liposomal-based hydrogels for controlled release of ferulic acid using magnetic fields stimulation Co-supervisor	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2024/11/18 - Current	Interactive section titled " From Sea to Light: LED's Friendly to Nature" that took place at Arco-Íris Primary School in Lisboa. Event part of the "Engineering and Science go to school" Program that connects young minds with groundbreaking innovations. (2024/11/18) Seminar (Co-organisor)
2018/09/06 - 2018/09/08	Member of the organizing committee in 15th International Conference on Computational Intelligence methods for Bioinformatics and Biostatistics. (2018/09/06 - 2018/09/08) Conference (Member of the Organising Committee)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/02/18 - 2018/02/22	Member of the organizing committee in EUSpec COST ACTION MP1306-Modern Tools for Spectroscopy on Advanced Materials (2018/02/18 - 2018/02/22) Conference (Member of the Organising Committee)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/11/27	Impact of Magnetic and Non-magnetic Imidazolium-based Ionic Liquids on Dipalmitoylphosphatidylcholine Vesicles (Thesis) Main arguer	Alice Dias (Master)
2023/12	Estudo da interação de um dispositivo de jato de plasma com moléculas de DNA (Thesis) Main arguer	FRANCISCO MARIA DE SOUSA NUNES MARQUES PINTO (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/02	Printing of magnetic hydrogels : formulation and applications in tissue engineering (Thesis) Main arguer	Duarte Almeida (Other) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/12	Cell-derived ECM loaded electrospun nanofibrous scaffolds for periodontal regeneration (Thesis) Main arguer	Mafalda Santos (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal

Journal scientific committee

	Journal title (ISSN)	Publisher
2021 - Current	separations (2297-8739)
2021 - Current	Journal of Molecular Liquids (0167-7322)
2021 - Current	The Journal of Nutritional Biochemistry (0955-2863)
2020 - Current	materials (1996-1944)	MDPI
2020 - Current	Colloids and Surfaces B: Biointerfaces (0927-7765)

Distinctions

Award

2018	Travel Grant for a Short Term Scientific Mission (COST, FINAL WORKSHOP AND MC_MEETING, MP1306) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017	Trainee Grant (only 20 people) to participate at the 1st Berlin Photon School at BESSY II Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Germany
2016	Trainee Grant for a Short Term Scientific Mission (COST 1st MOLIM Training School: From potentials to dynamic : The Starting Journey, CM1405) Universidade de Coimbra, Portugal
2016	Travel Grant for attending 4th Nanoscience and Nanontechnology International Conference International Iberian Nanotechnology Laboratory, Portugal
2016	Trainee Grant to participate at the 36th Berlin Neutron School Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Germany

Other distinction

2020	Cover Page: The impact of blue light in monolayers representing tumorigenic and nontumorigenic cell membranes containing epigallocatechin-3-gallate Colloids and Surfaces B Biointerfaces, Netherlands
2017	Funded user of ASTRID2 synchrotron radiation facility (ISA-17-1052) at beam line AU-UV. Aarhus Universitet, Denmark