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Joana Rodrigues. Completed the PhD in Genetics and Microbiology in 2017/08/30 by Newcastle University, Institute for Cell and Molecular Biosciences, the Masters in Molecular and Cellular Biology in 2012 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and a Degree in Biotechnology in 2009 by Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra.
Identification

Personal identification

Full name
Joana Rodrigues

Citation names

  • Rodrigues, Joana

Author identifiers

Ciência ID
571D-942F-D038
ORCID iD
0000-0002-3263-3887

Email addresses

  • joana.p.rodrigues@medicina.ulisboa.pt (Professional)

Addresses

  • Fundação GIMM - Gulbenkian Institute for Molecular Medicine, Avenida Professor Egas Moniz, 1649-028, Lisbon, Lisbon, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Advanced (C1)
Education
Degree Classification
2013/05/01 - 2017/08/30
Concluded
 Genetics and Microbiology (Doutoramento)
Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom
"YEAST GENOME-WIDE TELOMERE SCREENS AND INSIGHTS INTO CANCER" (THESIS/DISSERTATION)
2012
Concluded
 Masters in Molecular and Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Pyruvate dehydrogenase and mitochondrial function in Huntington’s disease models – influence of histone deacetylase inhibitors" (THESIS/DISSERTATION)
 18
2009
Concluded
 Degree in Biotechnology (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
"Controlo da forma celular em Bacillus subtilis: super-produção, purificação e análise dos domínios citoplasmático e extra-celular da proteína morfogénica RodZ" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2024/10/01 - Current Postdoc (Research) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2018/11/01 - 2024/09/30 Postdoc (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2017/09/01 - 2018/03/31 Research Assistant (Research) Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom
Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom
2013/05/01 - 2017/08/30 Researcher (Research) Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom
Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom
2011/09/01 - 2012/07/31 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/06/01 - 2010/06/30 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projects

Grant

Designation Funders
2013/05/01 - 2016/05/30 The role of Chronic DNA damage in Ageing and Age-related pathology
info:eu-repo/grantAgreement/EC/FP7/316354/EU
PhD Student Fellow
Newcastle University, United Kingdom
 European Commission
Concluded
2010/01/15 - 2010/06/15 Estudo da oligomerização dos domínios citoplasmático e extra-celular da proteína morfogénica RodZ
082/BI/2009
Scientific Initiation Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/05/01 - Current TRIAD: Enhancing Synergism on Telomere Function in Health and Disease
HORIZON-WIDERA 101158508 TRIAD
Horizon Europe Excellent Science
Ongoing
2021/03/29 - 2024/06/30 Assembly and functions of the mammalian telomeric deoxyribo/ribonucleoprotein particle at chromosome ends and beyond
PTDC/BIA-MOL/6624/2020
Post-doc
2018/10/01 - 2021/03/28 TERRA and telomerase­-mediated telomere elongation: unveiling novel molecular pathways towards the development of innovative therapeutic approaches for cancer treatment.  
C490695865-00081628
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Rego, Ana Cristina; Rodrigues, Joana; Cunha-Oliveira, Teresa; Ribeiro, Márcio; Rosenstock, Tatiana R.; Naia, Luana; Oliveira, Ana Margarida; Hayden, Michael R.. "Deficits of pyruvate dehydrogenase and mitochondrial dysfunction in Huntington's disease — role of histone deacetylase inhibitors". 2014.
    Published • 10.1016/j.bbabio.2014.05.003
Conference poster
  1. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in RNA in Disease - IX ptRNA meeting (Lisbon, Portugal), 2023.
  2. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in EMBO workshop ‘Telomere function and evolution in health and disease', 2022.
  3. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in RiboMed Satellite Conference on RNA in Disease, 2022.
  4. Rodrigues, Joana; Alfieri, Roberta; Bione, Silvia; Azzalin, Claus. "The human telomeric transcriptome". Paper presented in CSH Telomeres & Telomerase (Virtual meeting), 2021.
  5. Rodrigues, Joana; David Lydall. "PAF1 complex components regulate TERRA and telomere function". Paper presented in CSHL Telomeres & Telomerase 2017, 2017.
  6. Rodrigues, Joana; David Lydall. "PAF1 complex components regulate TERRA and telomere function". Paper presented in 2nd Cologne Ageing Conference, 2016.
  7. Rodrigues, Joana; David Lydall. "Interactions between the PAF1 complex, the ESCRT-II complex and telomere biology". Paper presented in EMBO Workshop - Telomeric chromatin and telomere fragility, 2015.
  8. Rosenstock, Tatiana; Rodrigues, Joana; Naia, Luana; Cunha-Oliveira, Teresa; Rego, Ana Cristina. "Impact of histone deacetylase inhibitors on pyruvate dehydrogenase and mitochondrial function in cellular models of Huntington's disease". Paper presented in 8th FENS Forum, 2012.
  9. Rodrigues, Joana; Rosenstock, Tatiana; Ribeiro, Mário; Ferreira, Luísa; Cunha-Oliveira, Teresa; Rego, A. Cristina. "Regulation of pyruvate dehydrogenase by histone deacetylase inhibitors in Huntington’s disease striatal cells.". Paper presented in 26a Reunião do Grupo de Estudo de Envelhecimento Cerebral e Demências, 2012.
  10. Naia, Luana; Rodrigues, Joana; Márcio Ribeiro; Ana I. Duarte; Cunha Ferreira, Teresa; Michael R. Hayden; Rego, A. Cristina. "Role of Insulin and IGF-1 on Glucose Metabolism in Striatal and Cortical Models of Huntington’s Disease". Paper presented in SINAL 2012 - 6th National Meeting on Cell Signaling, 2012.
  11. Rodrigues, Joana; Ribeiro, Márcio; Cunha-Oliveira, Teresa; Rego, Ana Cristina. "Insulin and IGF-1 effects in energy metabolism parameters in Huntington’s disease knock-in striatal cells". Paper presented in V Workshop Bioquímica, 2012.
Journal article
  1. Joana Rodrigues; Roberta Alfieri; Silvia Bione; Claus M. Azzalin. "TERRA ONTseq: a long-read-based sequencing pipeline to study the human telomeric transcriptome". RNA (2024): https://doi.org/10.1261/rna.079906.123.
    10.1261/rna.079906.123
  2. Joana Rodrigues; Peter Banks; David Lydall. "Vps74 Connects the Golgi Apparatus and Telomeres in Saccharomyces cerevisiae". G3: Genes|Genomes|Genetics 8 5 (2018): 1807-1816. https://doi.org/10.1534/g3.118.200172.
    10.1534/g3.118.200172
  3. Rodrigues J; Lydall D. "Cis and trans interactions between genes encoding PAF1 complex and ESCRT machinery components in yeast.". Current genetics (2018): http://europepmc.org/abstract/med/29564528.
    10.1007/s00294-018-0828-6
  4. Rodrigues J; Lydall D. "Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.". Nucleic acids research (2018): http://europepmc.org/abstract/med/29145644.
    10.1093/nar/gkx1131
  5. Luana Naia; Teresa Cunha-Oliveira; Joana Rodrigues; Tatiana R. Rosenstock; Ana Oliveira; Márcio Ribeiro; Catarina Carmo; et al. "Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease". The Journal of Neuroscience 37 10 (2017): 2776-2794. https://doi.org/10.1523%2Fjneurosci.2006-14.2016.
    10.1523/JNEUROSCI.2006-14.2016
  6. Naia L; Ribeiro M; Rodrigues J; Duarte AI; Lopes C; Rosenstock TR; Hayden MR; Rego AC. "Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin.". (2016): http://europepmc.org/abstract/med/26876526.
    10.1016/j.npep.2016.01.009
  7. Silva A; Naia L; Dominguez A; Ribeiro M; Rodrigues J; Vieira OV; Lessmann V; Rego AC. "Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease.". (2015): http://europepmc.org/abstract/med/25896770.
    10.1159/000375447
  8. Ribeiro M; Silva AC; Rodrigues J; Naia L; Rego AC. "Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine.". (2013): http://europepmc.org/abstract/med/24008831.
    10.1093/toxsci/kft199
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/19 TERRA ONTseq: a long read-based sequencing pipeline to study the human telomeric transcriptome iMM Scientific Retreat
2016/07/04 PAF1 complex components regulate TERRA and telomere function Cell Division Biology Symposium
(Newcastle, United Kingdom)
2016/05/17 PAF1 complex components regulate TERRA and telomere function in budding yeast Cell Division Biology Symposium
2016/03/04 Distinct roles for the PAF1 complex in TERRA and telomere function ICaMB Postgraduate Research Symposium, Newcastle.
2015/09/21 Telomeres and Aging: From Yeast Genome wide screens to insights into cancer 3rd Joint CodeAge/ aDDRess/ Marriage Training Workshop on Genetic Model Organisms in Ageing Research
2015/03/26 Is there an adjacent gene effect between VPS36 and CDC73? The British Yeast Group Meeting
Manchester Institute of Biotechnology (MIB) (Manchester, United Kingdom)
2014/06/09 Cell Division - From Yeast Genome wide screens to insights into cancer 2nd CodeAge Training Workshop on "Regulation of the (Epi) Genome during Ageing"
(Crete, Greece)
2009/11/29 Control of cell shape by the novel bacterial core morphogenetic component RodZ Congresso MicroBioTec09
(Vilamoura, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017/06/12 - 2017/08/04 Investigation of the role of Vps74 in telomere biology
Co-supervisor
2016/01/04 - 2016/03/11 Mechanisms that affect fitness of cells with telomere defects
Co-supervisor
2015/01/05 - 2015/03/03 Investigating the role of UBP6 and CKA2 genes at uncapped telomeres in Saccharomyces cerevisiae
Co-supervisor

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2015/09/23 - 2015/09/23 Workshop on Scholarly Publishing & Writing.
Workshop
 CodeAge Complementary Skills Workshop on Scholarly Publishing & Writing
2013/10/11 - 2013/10/11 Round table to discuss the science/projects developed by the attendees.
Round table
 North East Fungal Forum
2010/02/27 - 2010/02/27 Hosted a stand showcasing bacterial diversity, providing insights and explanations to attendees.
Exhibition
 Um dia a saber a ciência
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Mentoring / Tutoring

Topic Student name
2024/01/04 - 2024/01/26 Generation of novel tools to increase telomere transcription Anna Badalamenti
2022/09/01 - 2023/10/23 TERRA-mediated recruitment of SMARCAL1 in response to Telomeric Replication Stress João Pedro Pina Rebelo
2020/01/27 - 2021/09/30 TERRA Transcription Profiles in Human Cancer Cells Miguel Alves
Distinctions

Award

2006 Award of Merit
2005 Award of Merit