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BSousa is a junior researcher at the Cancer Metastasis group at i3S, focusing on elucidating the mechanisms underlying the survival and therapeutic resistance of circulating tumor cells in metastatic breast cancer patients, with the ultimate aim of establishing a precision oncology platform. BSousa performed her Biochemistry BSc trainee at IPATIMUP, in 2007, being immediately awarded with a research grant in a collaboration project with SANOFI-Aventis. During this period, she built and molecularly characterize a large series of breast carcinomas, pinpointing specific biomarkers that were able to better identify basal-like breast cancer (PMID:20552547). In 2014, she completed her PhD in Pathology and Molecular Genetics, at ICBAS. BSousa demonstrated that cell-cell adhesion awarded by P-cadherin expression plays a role in breast cancer cell metabolism (PMID:25269858). This work was supervised by Joana Paredes and developed at Ipatimup (Porto, Portugal), with two international stays at Patterson Institute for Cancer Research, PICR (Manchester, UK), and at R&D department of Sanofi-Aventis (Toulouse, France). In 2015, she was awarded with a competitive FCT Postdoc grant to pursuit the ongoing projects, specifically on the role of P-cadherin in the oxidative stress impairment, and its impact in the metastatic process (PMID: 32920119). In this context, she joined Paulo Oliveira's lab, at UC-Biotech, Cantanhede, where she expanded her technical skills and solid expertise in cancer metabolism, namely with the Seahorse Technology, thus going further in her independent pathway. During this period, BSousa was also involved in the conception and writing of several funded grants, in which I participated as task leader, providing wet-lab support, as well as data analysis on her areas of expertise. She still published a review manuscript (PMID:31010154) and a book chapter (PMID: 31134496). In 2019, BSousa was awarded a Junior Researcher contract at i3S. She established in vitro 3D breast cancer cell spheroids and immune spheroids as models to answer the questions raised in her work, thus implementing a new scientific topic within her host group, dedicated to the study the mechanisms associated to the survival of circulating tumor cells (CTCs). As a member of the Porto Comprehensive Cancer Center (P.CCC)-Raquel Seruca consortium, she implemented a lab with specialized equipment, to isolate and characterize CTCs: the FDA-approved CellSearch, as well as DEPArrayPLUS technology, for which she is one of the three national certified users. This opportunity gave her the know-how, and the opportunity to close collaborate with clinical oncologists, enhancing the impact of her research line. During her career path, BSousa still actively pursued specific activities towards an independent career. She supervised one master student (2017), one international internship (2019), as well as she is currently co-supervising one master and two FCT-funded PhD students, recently awarded by Fulbright Portugal, Liga Portuguesa contra o Cancro and Sociedade Portuguesa de Oncologia. She is actively involved in scientific diffusion by the frequent invitations to lecture at GABBA and BEB PhD programs, as well as in medicine graduation at FMUP. She also attended different workshops/courses, such as Animal Science (FELASA C) and Research Project Management, and participated as an evaluator in national meetings. Her solid track record, in the last 5 years (including one maternity leave in 2021), is reflected in 7 papers (2 papers as 1st author and 5 as co-author) in international peer-reviewed journals and one book chapter. In total, I authored 28 publications, specifically being 1st author of 3 original papers and one review. The capacity to disseminate her results is reflected in the frequent invitations to speak in international cancer metabolism meetings, as well as in being selected for oral communications from first-author abstracts.
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Identification

Personal identification

Full name
Bárbara Beatriz Pinheiro Ribeiro de Sousa

Citation names

  • Sousa, Bárbara

Author identifiers

Ciência ID
5816-C95D-1E6F
ORCID iD
0000-0002-0990-022X
Researcher Id
K-8854-2014
Scopus Author Id
12777326600

Email addresses

  • bsousa@ipatimup.pt (Professional)
  • bbeatrizs@gmail.com (Personal)

Addresses

  • Rua Alfredo Allen 208, , 4200-135 , Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2023/06/13 - 2023/06/29
Ongoing
 Research Project Management, 3rd edition (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2018/12/31
Concluded
 P-cadherin breast cancer stem cell marker: an antioxidant for metabolic defects caused by loss of matrix attachment (Pós-doutoramento)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2018/09/10 - 2018/09/21
Concluded
 Laboratory Animal Science-FELASA C (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010/01/01 - 2014/12/15
Concluded
 Pathology and Molecular Genetics (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Underlying the role of P-cadherin expression in breast cancer cell metabolism" (THESIS/DISSERTATION)
2001/09/06 - 2007/07/28
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Immunohistochemical characterization of a series of invasive breast carcinomas using Tissue Microarrays" (THESIS/DISSERTATION)
 15/20
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2018/12/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2016/06/01 - 2016/08/05 Visiting Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/06/01 - 2013/07/31 Visiting Researcher (Research) Biopark by Sanofi, France
Biopark by Sanofi, France
2012/10/01 - 2012/12/17 Visiting Researcher (Research) PICR (Paterson Institute for Cancer Research, University of Manchester, Manchester), United Kingdom
PICR (Paterson Institute for Cancer Research, University of Manchester, Manchester), United Kingdom
2008/01/01 - 2009/12/31 Contracted Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2007/07/01 - 2007/12/31 Research Trainee (Research) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

Category
Host institution 		Employer
2010/01/01 - 2014/12/31 PhD student Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2008/09/01 - 2010/12/31 P-cadherin Expression: its effect in breast cancer metastasis and angiogenesis using in vivo animal models
SANO-AV
Research Fellow
Concluded

Contract

Designation Funders
2022/09/01 - 2023/08/08 Development of a workflow to capture circulating tumour cell (CTC) clusters from patients with metastatic breast cancer
CANCER METASTASIS
Researcher
Liga Portuguesa Contra o Cancro, Portugal
Ongoing

Other

Designation Funders
2018/06/01 - 2021/07/31 HOXB genes function in breast cancer
POCI-01-0145-FEDER-030562
Researcher
2017/01/01 - 2019/12/31 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015 - POCI-01-0145-FEDER-016390
Researcher
2016/05/01 - 2019/04/30 P-cadherin breast cancer stem cell marker: an anti-oxidant for metabolic defects caused by loss of matrix attachment
NORTE-01-0145-FEDER-00029
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2014/06/01 - 2015/05/05 Dasatinib as an option to treat P-cadherin-overexpressing poor prognosis breast cancer
Laço
Researcher
Concluded
2012/03/01 - 2015/02/28 ADHESION, DIFFERENTIATION AND INVASION: DIFFERENT PROCESSES, COMMON CADHERIN PLAYERS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F757052%F2011/PT
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Sousa, Bárbara; Ribeiro, Ana Sofia; Paredes, Joana. "Heterogeneity and Plasticity of Breast Cancer Stem Cells". In Advances in Experimental Medicine and Biology, 83-103. Springer International Publishing, 2019.
    Published • 10.1007/978-3-030-14366-4_5
Conference poster
  1. Castro, Maria Miguel. "The impact of cell-cell adhesion disruption on the survival of Inflammatory Breast Cancer tumor emboli (co-supervision)". Paper presented in Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2023.
  2. Esquível, Catarina. "P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer (co-supervision)". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2022.
  3. Castro, Maria Miguel. "The role of cell-cell adhesion in the survival of inflammatory breast cancer tumour emboli (co-supervision)". Paper presented in 5th ASPIC International Congress, 2022.
  4. Esquível, Catarina. "P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer (co-supervision)". Paper presented in 5th ASPIC International Congress, 2022.
  5. Castro, Maria Miguel. "The role of cell-cell adhesion in the survival of inflammatory breast cancer tumour emboli (co-supervision)". Paper presented in Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2022.
  6. Castro, Maria Miguel. "Effect of cell-cell adhesion disruption on anoikis resistance and aggregation in Inflammatory Breast Cancer Cells (co-supervision)". Paper presented in 5th PhDay, i3S, 2022.
  7. Sousa, Bárbara. "The anti-oxidant activity of P-cadherin promotes metastasis and doxorubicin resistance in breast cancer". Paper presented in EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment, Lisbon, Portugal, 2020.
  8. Sousa, Bárbara. "P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems". Paper presented in FEBS ADVANCED LECTURE COURSE ON ONCOMETABOLISM: From Conceptual Knowledge to Clinical Applications, Luso, Portugal, 2019.
  9. Sousa, Bárbara. "P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems". Paper presented in ISCaM 6th annual Meeting- Metabolic Adaptations and targets in Cancer, from International Society of Cancer Metabolism, Braga, Portugal, 2019.
  10. Sousa, Bárbara. "P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering he oxidative stress". Paper presented in 3rd ASPIC International Congress, Lisbon, Portugal, 2018.
  11. Sousa, Bárbara. "P-cadherin enrichment dictates sensitivity of breast cancer cells to DCA metabolic reprogramming". Paper presented in ISCaM 5th annual Meeting- Metabolic Adaptations and targets in Cancer, from International Society of Cancer Metabolism, Bratislava, Slovakia, 2018.
  12. Sousa, Bárbara. "P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative stress". Paper presented in 7th I3S Annual Meeting, Póvoa de Varzim, Portugal, 2018.
  13. Sousa, Bárbara. "Targeting anoikis-resistant P-cadherin-enriched Breast Cancer Cells by in vitro Metabolic Reprograming". Paper presented in 10th IJUP Edition, Encontro de Investigação Jovem, Porto, Portugal, 2017.
  14. Sousa, Bárbara. "P-cadherin enrichment dictates sensitivity of breast cancer cells to DCA metabolic reprogramming". Paper presented in FEBS ADVANCED LECTURE COURSE ON ONCOMETABOLISM: From Conceptual Knowledge to Clinical Applications, Figueira da Foz, Portugal, 2017.
  15. Sousa, Bárbara. "P-cadherin: an antioxidant for metabolic defects in breast cancer stem cells?". Paper presented in 4th I3S Annual Meeting, Póvoa de Varzim, Portugal, 2016.
  16. Sousa, Bárbara. "The basal epitelial marker P-cadherin associates with breast cancer cell population harbouring a hypoxia-resistant phenotype". Paper presented in 5th French Cell Adhesion Club Symposium, Marseille, France, 2014.
  17. Sousa, Bárbara. "P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014.
  18. Sousa, Bárbara. "P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells". Paper presented in 4th I3S Annual Meeting, Póvoa de Varzim, Portugal, 2014.
  19. Sousa, Bárbara. "P-cadherin expression in breast cancer: its association with glycolytic and acid-resistant phenotypes". Paper presented in XXII Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2013.
  20. Sousa, Bárbara. "Aberrant expression of the CSC marker P-cadherin is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 28th IABCR/Breakthrough Breast Cancer Conference, Manchester, UK, 2012.
  21. Sousa, Bárbara. "Aberrant expression of the CSC marker P-cadherin is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in : XXI Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2012.
  22. Sousa, Bárbara. "Aberrant expression of the CSC marker P-cadherin is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Biblioteca Almeida Garret, Jardins do Palácio de Cristal, Porto, Portugal, 2012.
  23. Sousa, Bárbara. "P-cadherin cancer stem cell marker: its role in breast cancer brain metastasis". Paper presented in : 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Biblioteca Almeida Garret, Jardins do Palácio de Cristal, Porto, Portugal, 2012.
  24. Sousa, Bárbara. "Aberrant P-cadherin expression is associated with glycolytic and acid-resistant phenotype in invasive breast carcinoma". Paper presented in : 3rd I3S Annual Meeting, Póvoa de Varzim, Portugal, 2012.
  25. Sousa, Bárbara. "P-cadherin activates Src-kinase: A new signaling pathway with implications in breast cancer progression". Paper presented in 3rd I3S Annual Meeting, Póvoa de Varzim, Portugal, 2012.
  26. Sousa, Bárbara. "P-cadherin aberrant expression is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 2nd I3S Annual Meeting, Povoa de Varzim, Portugal, 2011.
  27. Sousa, Bárbara. "P-cadherin aberrant expression is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in European Network of breast development and cancer workshop, Weggis, Switzerland, 2011.
  28. Sousa, Bárbara. "P-cadherin aberrant expression is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 1st Advanced Summer School - Interrogations at the Biointerface, Porto, Portugal, 2011.
  29. Sousa, Bárbara. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study". Paper presented in I3S Annual Meeting, Póvoa do Varzim, Portugal, 2010.
  30. Sousa, Bárbara. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study". Paper presented in XXXV Jornadas Portuguesas de Genética, Braga, Portugal, 2010.
Journal article
  1. Fonseca, Irina; Horta, Cíntia; Ribeiro, Ana Sofia; Sousa, Barbara; Marteil, Gaëlle; Bettencourt-Dias, Mónica; Paredes, Joana. "Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype". Cell Death & Disease 14 2 (2023): http://dx.doi.org/10.1038/s41419-023-05618-1.
    10.1038/s41419-023-05618-1
  2. Tavares-Valente, Diana; Sousa, Bárbara; Schmitt, Fernando; Baltazar, Fátima; Queirós, Odília. "Disruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells". (2021):
    10.3390/pharmaceutics13020242
  3. Sousa, Bárbara; Pereira, Joana; Marques, Ricardo; Grilo, Luís F.; Pereira, Susana P.; Sardão, Vilma A.; Schmitt, Fernando; Oliveira, Paulo J.; Paredes, Joana. "P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 12 (2020): 165964. http://dx.doi.org/10.1016/j.bbadis.2020.165964.
    10.1016/j.bbadis.2020.165964
  4. Flávia Martins; Rosa Oliveira; Bruno Cavadas; Filipe Pinto; Ana Cardoso; Flávia Castro; Bárbara Sousa; et al. "Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer". Cancers (2020): https://www.mdpi.com/2072-6694/12/4/818.
    10.3390/cancers12040818
  5. Bárbara Sousa; Joana Pereira; Joana Paredes. "The Crosstalk Between Cell Adhesion and Cancer Metabolism". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/8/1933.
    10.3390/ijms20081933
  6. Ribeiro, Ana Sofia; Nobre, Ana Rita; Mendes, Nuno; Almeida, João; Vieira, André Filipe; Sousa, Bárbara; Carvalho, Filomena A.; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell Communication and Signaling 16 1 (2018): http://dx.doi.org/10.1186/s12964-018-0286-2.
    10.1186/s12964-018-0286-2
  7. Hoffmann C; Mao X; Brown-Clay J; Moreau F; Al Absi A; Wurzer H; Sousa B; et al. "Hypoxia promotes breast cancer cell invasion through HIF-1a-mediated up-regulation of the invadopodial actin bundling protein CSRP2.". Scientific reports (2018): http://europepmc.org/abstract/med/29976963.
    10.1038/s41598-018-28637-x
  8. Figueiredo J; Rodrigues I; Ribeiro J; Fernandes MS; Melo S; Sousa B; Paredes J; Seruca R; Sanches JM. "Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept.". Scientific reports (2018): http://europepmc.org/abstract/med/29980764.
    10.1038/s41598-018-28570-z
  9. Oliveira P; Carvalho J; Rocha S; Azevedo M; Reis I; Camilo V; Sousa B; et al. "Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation.". (2016): http://europepmc.org/abstract/med/27721458.
    10.1038/srep34860
  10. Vieira, A.F.; Ribeiro, A.S.; Dionísio, M.R.; Sousa, B.; Nobre, A.R.; Albergaria, A.; Santiago-Gómez, A.; et al. "P-cadherin signals through the laminin receptor a6ß4 integrin to induce stem cell and invasive properties to basal-like breast cancer cells". Oncotarget 5 3 (2014): 679-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896821980&partnerID=MN8TOARS.
  11. Sousa, B.; Ribeiro, A.S.; Nobre, A.R.; Lopes, N.; Martins, D.; Pinheiro, C.; Vieira, A.F.; et al. "The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype". BMC Cancer 14 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84908094892&partnerID=MN8TOARS.
    10.1186/1471-2407-14-734
  12. Moniz, S.; Martinho, O.; Pinto, F.; Sousa, B.; Loureiro, C.; Oliveira, M.J.; Moita, L.F.; et al. "Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness". Human Molecular Genetics 22 1 (2013): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871200220&partnerID=MN8TOARS.
    10.1093/hmg/dds405
  13. Albergaria, A.; Resende, C.; Nobre, A.R.; Ribeiro, A.S.; Sousa, B.; Machado, J.C.; Seruca, R.; Paredes, J.; Schmitt, F.. "CCAAT/Enhancer Binding Protein ß (C/EBPß) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873547668&partnerID=MN8TOARS.
    10.1371/journal.pone.0055749
  14. Ribeiro, A.S.; Sousa, B.; Carreto, L.; Mendes, N.; Nobre, A.R.; Ricardo, S.; Albergaria, A.; et al. "P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model". Journal of Pathology 229 5 (2013): 705-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875054847&partnerID=MN8TOARS.
    10.1002/path.4143
  15. Martins, D.; Beça, F.F.; Sousa, B.; Baltazar, F.; Paredes, J.; Schmitt, F.. "Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma Key events in the progression from an in situ to an invasive breast carcinoma". Cell Cycle 12 16 (2013): 2684-2690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883237456&partnerID=MN8TOARS.
    10.4161/cc.25794
  16. Lopes, N.; Carvalho, J.; Durães, C.; Sousa, B.; Gomes, M.; Costa, J.L.; Oliveira, C.; Paredes, J.; Schmitt, F.. "1Alpha,25-dihydroxyvitamin D 3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation". Anticancer Research 32 1 PART 2 (2012): 249-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856024024&partnerID=MN8TOARS.
  17. Albergaria, A.; Ribeiro, A.-S.; Vieira, A.-F.; Sousa, B.; Nobre, A.-R.; Seruca, R.; Schmitt, F.; Paredes, J.. "P-cadherin role in normal breast development and cancer". International Journal of Developmental Biology 55 7-9 (2011): 811-822. http://www.scopus.com/inward/record.url?eid=2-s2.0-82555201366&partnerID=MN8TOARS.
    10.1387/ijdb.113382aa
  18. Martins, D.; Sousa, B.; Lopes, N.; Gomes, M.; Veronese, L.; Albergaria, A.; Paredes, J.; Schmitt, F.. "Molecular phenotypes of matched in situ and invasive components of breast carcinomas". Human Pathology 42 10 (2011): 1438-1446. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053182840&partnerID=MN8TOARS.
    10.1016/j.humpath.2010.08.024
  19. Pinheiro, C.; Sousa, B.; Albergaria, A.; Paredes, J.; Dufloth, R.; Vieira, D.; Schmitt, F.; Baltazar, F.. "GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression". Histology and Histopathology 26 10 (2011): 1279-1286. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053319008&partnerID=MN8TOARS.
  20. Ribeiro, A.S.; Albergaria, A.; Sousa, B.; Correia, A.L.; Bracke, M.; Seruca, R.; Schmitt, F.C.; Paredes, J.. "Extracellular cleavage and shedding of P-cadherin: A mechanism underlying the invasive behaviour of breast cancer cells". Oncogene 29 3 (2010): 392-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149183984&partnerID=MN8TOARS.
    10.1038/onc.2009.338
  21. Albergaria, A.; Ribeiro, A.S.; Pinho, S.; Milanezi, F.; Carneiro, V.; Sousa, B.; Sousa, S.; et al. "ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: A role for C/EBPß in CDH3 gene activation". Human Molecular Genetics 19 13 (2010): 2554-2566. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954172745&partnerID=MN8TOARS.
    10.1093/hmg/ddq134
  22. Pinheiro, C.; Albergaria, A.; Paredes, J.; Sousa, B.; Dufloth, R.; Vieira, D.; Schmitt, F.; Baltazar, F.. "Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma". Histopathology 56 7 (2010): 860-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953195898&partnerID=MN8TOARS.
    10.1111/j.1365-2559.2010.03560.x
  23. Sousa, B.; Paredes, J.; Milanezi, F.; Lopes, N.; Martins, D.; Dufloth, R.; Vieira, D.; et al. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: An immunohistochemical study". Histology and Histopathology 25 8 (2010): 963-974. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956895496&partnerID=MN8TOARS.
  24. Lopes, N.; Sousa, B.; Martins, D.; Gomes, M.; Vieira, D.; Veronese, L.A.; Milanezi, F.; et al. "Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: A study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions". BMC Cancer 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956478256&partnerID=MN8TOARS.
    10.1186/1471-2407-10-483
  25. Ribeiro AS; Carreto LC; Albergaria A; Sousa B; Ricardo S; Milanezi F; Seruca R; et al. "Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?". (2010): http://europepmc.org/abstract/PMC/PMC3255045.
  26. Rodrigues, Ligia R.; Lopes, Nair; Sousa, Barbara; Vieira, Daniella; Milanezi, Fernanda; Paulsson, Marie; Lindmark-Mansson, Helena; Teixeira, Jose A.; Schmitt, Fernando. "Significance of Osteopontin Expression in Human Invasive Breast Tumour Stroma". The Open Breast Cancer Journal 1 1 (2009): 1-9. http://dx.doi.org/10.2174/1876817200901010001.
    10.2174/1876817200901010001
  27. Lopes, N.; Sousa, B.; Vieira, D.; Milanezi, F.; Schmitt, F.. "Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles". Histopathology 55 5 (2009): 594-599. http://www.scopus.com/inward/record.url?eid=2-s2.0-71049118533&partnerID=MN8TOARS.
    10.1111/j.1365-2559.2009.03417.x
  28. Albergaria, A.; Paredes, J.; Sousa, B.; Milanezi, F.; Carneiro, V.; Bastos, J.; Costa, S.; et al. "Expression of FOXA1 and GATA-3 in breast cancer: The prognostic significance in hormone receptor-negative tumours". Breast Cancer Research 11 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-74049137968&partnerID=MN8TOARS.
    10.1186/bcr2327
Thesis / Dissertation
  1. "Joana Sousa Pereira: Targeting anoikis-resistant P-cadherin-enriched breast cancer cells by in vitro metabolic reprograming". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2017.
  2. Sousa, Bárbara. "Underlying the role of P-cadherin expression in breast cancer cell metabolism". PhD, 2014.
  3. Sousa, Bárbara. "Immunohistochemical characterization of a series of invasive breast carcinomas using Tissue Microarrays". Degree, 2007.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05/10 P-cadherin-mediated cell-cell adhesion: its role on immune evasion in metastatic breast cancer (co-supervision) IJUP Edition, Encontro de Investigação Jovem, Porto, Portugal
(Porto, Portugal)
2022/05/04 P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer (co-supervision) 15th Encontro de Investigação Jovem da Universidade do Porto
(Porto, Portugal)
2021/11/19 P-cadherin as a phenotypic stability factor of the hybrid epithelial/mesenchymal phenotype in breast cancer (co-supervision) 18th National Congress on Oncology, November
Sociedade Portuguesa de Oncologia
2019/11 The anti-oxidant activity of P-cadherin promotes metastasis and therapy resistance in breast cancer 8th i3S Annual Meeting
(Povoa de Varzim, Portugal)
2019/09 P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems Oncometabolism: From Conceptual Knowledge to Clinical Applications
(Luso, Portugal)
2019/09 The anti-oxidant activity of P-cadherin promotes metastasis and doxorubicin resistance in breast cancer MAC’19- 6th Biannual Meeting on Mitochondria, Apoptosis & Cancer
(Praga, Czech Republic)
2019/01 Circulating CSCs: how to survive upon metabolic alterations caused by matrix detachment CANCEL STEM Consortium Meeting
UC-Biotech, Cantanhede, Portugal (Cantanhede, Portugal)
2018/10 P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative stress ISCaM 5th annual Meeting- Metabolic Adaptations and targets in Cancer, from International Society of Cancer Metabolism
(Bratislava, Slovakia)
2017/10 P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
(Covilhã, Portugal)
2017/07 P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells FEBS ADVANCED LECTURE COURSE ON ONCOMETABOLISM: From Conceptual Knowledge to Clinical Applications
(Figueira da Foz, Portugal)
2016/11 P-cadherin: an antioxidant for metabolic defects in breast cancer stem cells 5th I3S Scientific Retreat, IBMC/INEB/IPATIMUP
(Povoa de Varzim, Portugal)
2015/10 P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
(Lisboa, Portugal)
2014/05 E-cadherin and P-cadherin: their crosstalk in breast cancer cells 5th French Cell Adhesion Club Symposium
(Marselha, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/01/01 - Current P-cadherin-mediated cell-cell adhesion: its role in hybrid E/M phenotype and immune evasion in metastatic breast cancer (co-supervision)
Co-supervisor
 Patologia e Genética Molecular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - Current The role of cell-cell adhesion in the survival of inflammatory breast cancer tumor emboli (co-supervision)
Co-supervisor
 Patologia e Genética Molecular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/01 - 2023/09/30 P-cadherin-mediated cell-cell adhesion: its role on immune evasion in metastatic breast cancer (co-supervision)
Co-supervisor
 Mestrado em Bioquímica Clínica (Master)
Universidade de Aveiro, Portugal
2019/01/01 - 2019/06/30 Evaluate the role of P-cadherin in the doxorubicin resistance of breast cancer stem cells
Co-supervisor
 Bio-Medical Laboratory Technology bachelor (Degree)
Universiteit Gent, Belgium
2016/09 - 2017/09 Targeting anoikis-resistant P-cadherin-enriched Breast Cancer Cells by in vitro Metabolic Reprograming
Co-supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/01/13 - Current Ciencia et al- i3s Educational Program
Workshop
 A Herança dos Maias
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/10/01 - Current Science Ambassador at i3S Educational Program: Circulating Tumor Cells and Breast Cancer
Exhibition
 Ciencia et al
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Current Exposição coletiva de Fotografias “O CANCRO VISTO AO MICROSCÓPIO”
Exhibition
 Exposição coletiva de Fotografias “O CANCRO VISTO AO MICROSCÓPIO”
Universidade de Aveiro, Portugal
2007 - Current Participation in "Ciência Viva" exhibitions
Ciência Viva, Portugal
2007 - Current Dissemination of scientific research within an exhibition promoted by University of Porto targeting high school students: MOSTRA UP MOSTRA UP
Universidade do Porto, Portugal
2014/11/14 - 2014/11/15 Ipatimup - 2 Dias Abertos
Exhibition
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/05/05 - 2014/05/12 Exposição: Cancro, Ciência e Cidade: Os Passos da Ciência nos Paços do Concelho
Meeting
 Exposição: Cancro, Ciência e Cidade: Os Passos da Ciência nos Paços do Concelho
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Câmara Municipal do Porto, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/30 Tumor spheroids as 3D models to evaluate the efficacy of Azurin-expressing Mesenchymal Stromal Cells-secretome as a potential anticancer therapy
(Thesis) Main arguer
 Alexandra Amaral Barbosa (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - 2020 Participation in Invasion and Mestatasis module Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019 Participation in Invasion and Mestatasis module Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019 Participation in Oncometabolism module at BEB PhD programme Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2017 - 2018 Participation in Oncobiology module in the lesson: Cancer stemness and differentiation 20th GABBA Edition (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018 Participation in Invasion and Mestatasis module Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018/02 - 2018/02 Avaliador/Moderador de sessão de comunicações orais no 11º Encontro de Jovens Investigadores da U.PORTO
Evaluator
Distinctions

Award

2023 Fulbright award: "Studying the impact of cell-cell adhesion on the metastatic process of Inflammatory Breast Cancer" (co-supervision)
Fulbright Portugal, Portugal
2022 Bolsa de Investigação em Oncologia LPCC-NRS 2022 (co-supervision)
Liga Portuguesa Contra o Cancro, Portugal
2022 Best Oral Communication at 15th Encontro de Investigação Jovem da Universidade do Porto 2022 (co-supervision)
2021 Best Oral Communication at 18th National Congress on Oncology 2021 (co-supervision)
2012 3rd Award of Oncology poster session in 3rd I3S Scientific Retreat – IBMC/INEB/IPATIMUP, Póvoa de Varzim, Portugal.
2012 Best Poster Award - mTOR expression in basal-like breast cancer and the ability of Everolimus to inhibit the invasion cancer cell capacity (co-author)