Bárbara Beatriz Pinheiro Ribeiro de Sousa (5816-C95D-1E6F)

Curriculum Vitae

Bárbara Beatriz Pinheiro Ribeiro de Sousa

BSousa is a junior researcher at the Cancer Metastasis group at i3S, focusing on elucidating the mechanisms underlying the survival and therapeutic resistance of circulating tumor cells in metastatic breast cancer patients, with the ultimate aim of establishing a precision oncology platform. BSousa performed her Biochemistry BSc trainee at IPATIMUP, in 2007, being immediately awarded with a research grant in a collaboration project with SANOFI-Aventis. During this period, she built and molecularly characterize a large series of breast carcinomas, pinpointing specific biomarkers that were able to better identify basal-like breast cancer (PMID:20552547). In 2014, she completed her PhD in Pathology and Molecular Genetics, at ICBAS. BSousa demonstrated that cell-cell adhesion awarded by P-cadherin expression plays a role in breast cancer cell metabolism (PMID:25269858). This work was supervised by Joana Paredes and developed at Ipatimup (Porto, Portugal), with two international stays at Patterson Institute for Cancer Research, PICR (Manchester, UK), and at R&D department of Sanofi-Aventis (Toulouse, France). In 2015, she was awarded with a competitive FCT Postdoc grant to pursuit the ongoing projects, specifically on the role of P-cadherin in the oxidative stress impairment, and its impact in the metastatic process (PMID: 32920119). In this context, she joined Paulo Oliveira's lab, at UC-Biotech, Cantanhede, where she expanded her technical skills and solid expertise in cancer metabolism, namely with the Seahorse Technology, thus going further in her independent pathway. During this period, BSousa was also involved in the conception and writing of several funded grants, in which I participated as task leader, providing wet-lab support, as well as data analysis on her areas of expertise. She still published a review manuscript (PMID:31010154) and a book chapter (PMID: 31134496). In 2019, BSousa was awarded a Junior Researcher contract at i3S. She established in vitro 3D breast cancer cell spheroids and immune spheroids as models to answer the questions raised in her work, thus implementing a new scientific topic within her host group, dedicated to the study the mechanisms associated to the survival of circulating tumor cells (CTCs). As a member of the Porto Comprehensive Cancer Center (P.CCC)-Raquel Seruca consortium, she implemented a lab with specialized equipment, to isolate and characterize CTCs: the FDA-approved CellSearch, as well as DEPArrayPLUS technology, for which she is one of the three national certified users. This opportunity gave her the know-how, and the opportunity to close collaborate with clinical oncologists, enhancing the impact of her research line. During her career path, BSousa still actively pursued specific activities towards an independent career. She supervised one master student (2017), one international internship (2019), as well as she is currently co-supervising one master and two FCT-funded PhD students, recently awarded by Fulbright Portugal, Liga Portuguesa contra o Cancro and Sociedade Portuguesa de Oncologia. She is actively involved in scientific diffusion by the frequent invitations to lecture at GABBA and BEB PhD programs, as well as in medicine graduation at FMUP. She also attended different workshops/courses, such as Animal Science (FELASA C) and Research Project Management, and participated as an evaluator in national meetings. Her solid track record, in the last 5 years (including one maternity leave in 2021), is reflected in 7 papers (2 papers as 1st author and 5 as co-author) in international peer-reviewed journals and one book chapter. In total, I authored 28 publications, specifically being 1st author of 3 original papers and one review. The capacity to disseminate her results is reflected in the frequent invitations to speak in international cancer metabolism meetings, as well as in being selected for oral communications from first-author abstracts.

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Identification

Personal identification

Full name: Bárbara Beatriz Pinheiro Ribeiro de Sousa

Citation names

Sousa, Bárbara

Author identifiers

Ciência ID: 5816-C95D-1E6F
ORCID iD: 0000-0002-0990-022X
Researcher Id: K-8854-2014
Scopus Author Id: 12777326600

Email addresses

bsousa@ipatimup.pt (Professional)
bbeatrizs@gmail.com (Personal)

Addresses

Rua Alfredo Allen 208, , 4200-135 , Porto, Porto, Portugal (Professional)

Websites

https://www.i3s.up.pt/content/people?id=173&idg=17 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2023/06/13 - 2023/06/29 Ongoing	Research Project Management, 3rd edition (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2018/12/31 Concluded	P-cadherin breast cancer stem cell marker: an antioxidant for metabolic defects caused by loss of matrix attachment (Pós-doutoramento) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2018/09/10 - 2018/09/21 Concluded	Laboratory Animal Science-FELASA C (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010/01/01 - 2014/12/15 Concluded	Pathology and Molecular Genetics (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Underlying the role of P-cadherin expression in breast cancer cell metabolism" (THESIS/DISSERTATION)
2001/09/06 - 2007/07/28 Concluded	Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Immunohistochemical characterization of a series of invasive breast carcinomas using Tissue Microarrays" (THESIS/DISSERTATION)	15/20

Affiliation

Science

	Category Host institution	Employer
2019/01/01 - Current	Contracted Researcher (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2018/12/31	Postdoc (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2016/06/01 - 2016/08/05	Visiting Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/06/01 - 2013/07/31	Visiting Researcher (Research)	Biopark by Sanofi, France
	Biopark by Sanofi, France
2012/10/01 - 2012/12/17	Visiting Researcher (Research)	PICR (Paterson Institute for Cancer Research, University of Manchester, Manchester), United Kingdom
	PICR (Paterson Institute for Cancer Research, University of Manchester, Manchester), United Kingdom
2008/01/01 - 2009/12/31	Contracted Researcher (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2007/07/01 - 2007/12/31	Research Trainee (Research)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

	Category Host institution	Employer
2010/01/01 - 2014/12/31	PhD student	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Projects

Grant

	Designation	Funders
2022/09/01 - 2023/08/08	Development of a workflow to capture circulating tumour cell (CTC) clusters from patients with metastatic breast cancer CANCER METASTASIS Researcher Liga Portuguesa Contra o Cancro, Portugal	Concluded
2008/09/01 - 2010/12/31	P-cadherin Expression: its effect in breast cancer metastasis and angiogenesis using in vivo animal models SANO-AV Research Fellow	Concluded

Other

	Designation	Funders
2018/06/01 - 2021/07/31	HOXB genes function in breast cancer POCI-01-0145-FEDER-030562 Researcher
2017/01/01 - 2019/12/31	Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy SAICTPAC/0022/2015 - POCI-01-0145-FEDER-016390 Researcher
2016/05/01 - 2019/04/30	P-cadherin breast cancer stem cell marker: an anti-oxidant for metabolic defects caused by loss of matrix attachment NORTE-01-0145-FEDER-00029 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2014/06/01 - 2015/05/05	Dasatinib as an option to treat P-cadherin-overexpressing poor prognosis breast cancer Laço Researcher	Concluded
2012/03/01 - 2015/02/28	ADHESION, DIFFERENTIATION AND INVASION: DIFFERENT PROCESSES, COMMON CADHERIN PLAYERS info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F757052%F2011/PT Researcher	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Sousa, Bárbara; Ribeiro, Ana Sofia; Paredes, Joana. "Heterogeneity and Plasticity of Breast Cancer Stem Cells". In Advances in Experimental Medicine and Biology, 83-103. Springer International Publishing, 2019. Published • 10.1007/978-3-030-14366-4_5
Conference poster	Castro, Maria Miguel. "O impacto da perda de adesão célula-célula na sobrevivência de êmbolos tumorais de cancro da mama inflamatório (co-supervision)". Paper presented in ENJIO 2023, Liga Portuguesa Contra o Cancro, 2023, 2024. Castro, Maria Miguel. "Cell-cell adhesion disruption impacts the survival of inflammatory breast cancer cells (co-supervision)". Paper presented in XXII Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2024. Sousa, Bárbara. "Development of a workflow to capture circulating tumor cell (CTC) clusters from patients with metastatic breast cancer". Paper presented in XXII Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2024. Esquível, Catarina. "P-cadherin expression is a biomarker of a hybrid EMT phenotype (co-supervision)". Paper presented in XXII Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2024. Sousa, Bárbara. "Development of a workflow to capture circulating tumor cell (CTC) clusters from patients with metastatic breast cancer". Paper presented in 6th ASPIC International Congress, 2024. Esquível, Catarina. "P-cadherin expression is a biomarker of a hybrid EMT phenotype (co-supervision)". Paper presented in 6th ASPIC International Congress, 2024. Castro, Maria Miguel. "The impact of cell-cell adhesion disruption on the survival of Inflammatory Breast Cancer tumor emboli (co-supervision)". Paper presented in Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2023. cristiana moreira tomaz. "P-cadherin-mediated cell-cell adhesion: Its role on immune evasion in metastasis breast cancer (co-supervision)". Paper presented in IJUP Edition, Encontro de Investigação Jovem, Porto, Portugal, 2023. cristiana moreira tomaz. "A adesão célula-célula mediada pela caderina-P induz um metabolismo glicolítico em células do cancro da mama (co-supervision)". Paper presented in ENJIO 2023, Liga Portuguesa Contra o Cancro, 2023, 2022. Esquível, Catarina. "P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer (co-supervision)". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2022. Castro, Maria Miguel. "The role of cell-cell adhesion in the survival of inflammatory breast cancer tumour emboli (co-supervision)". Paper presented in 5th ASPIC International Congress, 2022. Esquível, Catarina. "P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer (co-supervision)". Paper presented in 5th ASPIC International Congress, 2022. Castro, Maria Miguel. "The role of cell-cell adhesion in the survival of inflammatory breast cancer tumour emboli (co-supervision)". Paper presented in Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2022. Castro, Maria Miguel. "Effect of cell-cell adhesion disruption on anoikis resistance and aggregation in Inflammatory Breast Cancer Cells (co-supervision)". Paper presented in 5th PhDay, i3S, 2022. Sousa, Bárbara. "The anti-oxidant activity of P-cadherin promotes metastasis and doxorubicin resistance in breast cancer". Paper presented in EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment, Lisbon, Portugal, 2020. Sousa, Bárbara. "P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems". Paper presented in FEBS ADVANCED LECTURE COURSE ON ONCOMETABOLISM: From Conceptual Knowledge to Clinical Applications, Luso, Portugal, 2019. Sousa, Bárbara. "P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems". Paper presented in ISCaM 6th annual Meeting- Metabolic Adaptations and targets in Cancer, from International Society of Cancer Metabolism, Braga, Portugal, 2019. Sousa, Bárbara. "P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering he oxidative stress". Paper presented in 3rd ASPIC International Congress, Lisbon, Portugal, 2018. Sousa, Bárbara. "P-cadherin enrichment dictates sensitivity of breast cancer cells to DCA metabolic reprogramming". Paper presented in ISCaM 5th annual Meeting- Metabolic Adaptations and targets in Cancer, from International Society of Cancer Metabolism, Bratislava, Slovakia, 2018. Sousa, Bárbara. "P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative stress". Paper presented in 7th I3S Annual Meeting, Póvoa de Varzim, Portugal, 2018. Sousa, Bárbara. "Targeting anoikis-resistant P-cadherin-enriched Breast Cancer Cells by in vitro Metabolic Reprograming". Paper presented in 10th IJUP Edition, Encontro de Investigação Jovem, Porto, Portugal, 2017. Sousa, Bárbara. "P-cadherin enrichment dictates sensitivity of breast cancer cells to DCA metabolic reprogramming". Paper presented in FEBS ADVANCED LECTURE COURSE ON ONCOMETABOLISM: From Conceptual Knowledge to Clinical Applications, Figueira da Foz, Portugal, 2017. Sousa, Bárbara. "P-cadherin: an antioxidant for metabolic defects in breast cancer stem cells?". Paper presented in 4th I3S Annual Meeting, Póvoa de Varzim, Portugal, 2016. Sousa, Bárbara. "The basal epitelial marker P-cadherin associates with breast cancer cell population harbouring a hypoxia-resistant phenotype". Paper presented in 5th French Cell Adhesion Club Symposium, Marseille, France, 2014. Sousa, Bárbara. "P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells". Paper presented in 1st ASPIC International Congress, Lisbon, Portugal, 2014. Sousa, Bárbara. "P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells". Paper presented in 4th I3S Annual Meeting, Póvoa de Varzim, Portugal, 2014. Sousa, Bárbara. "P-cadherin expression in breast cancer: its association with glycolytic and acid-resistant phenotypes". Paper presented in XXII Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2013. Sousa, Bárbara. "Aberrant expression of the CSC marker P-cadherin is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 28th IABCR/Breakthrough Breast Cancer Conference, Manchester, UK, 2012. Sousa, Bárbara. "Aberrant expression of the CSC marker P-cadherin is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in : XXI Porto Cancer Meeting, IPATIMUP, Porto, Portugal, 2012. Sousa, Bárbara. "Aberrant expression of the CSC marker P-cadherin is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Biblioteca Almeida Garret, Jardins do Palácio de Cristal, Porto, Portugal, 2012. Sousa, Bárbara. "P-cadherin cancer stem cell marker: its role in breast cancer brain metastasis". Paper presented in : 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Biblioteca Almeida Garret, Jardins do Palácio de Cristal, Porto, Portugal, 2012. Sousa, Bárbara. "Aberrant P-cadherin expression is associated with glycolytic and acid-resistant phenotype in invasive breast carcinoma". Paper presented in : 3rd I3S Annual Meeting, Póvoa de Varzim, Portugal, 2012. Sousa, Bárbara. "P-cadherin activates Src-kinase: A new signaling pathway with implications in breast cancer progression". Paper presented in 3rd I3S Annual Meeting, Póvoa de Varzim, Portugal, 2012. Sousa, Bárbara. "P-cadherin aberrant expression is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 2nd I3S Annual Meeting, Povoa de Varzim, Portugal, 2011. Sousa, Bárbara. "P-cadherin aberrant expression is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in European Network of breast development and cancer workshop, Weggis, Switzerland, 2011. Sousa, Bárbara. "P-cadherin aberrant expression is associated with hypoxic/ glycolytic and acid resistant phenotype in breast carcinomas". Paper presented in 1st Advanced Summer School - Interrogations at the Biointerface, Porto, Portugal, 2011. Sousa, Bárbara. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study". Paper presented in I3S Annual Meeting, Póvoa do Varzim, Portugal, 2010. Sousa, Bárbara. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study". Paper presented in XXXV Jornadas Portuguesas de Genética, Braga, Portugal, 2010.
Journal article	Fonseca, Irina; Horta, Cíntia; Ribeiro, Ana Sofia; Sousa, Barbara; Marteil, Gaëlle; Bettencourt-Dias, Mónica; Paredes, Joana. "Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype". Cell Death & Disease 14 2 (2023): http://dx.doi.org/10.1038/s41419-023-05618-1. 10.1038/s41419-023-05618-1 Tavares-Valente, Diana; Sousa, Bárbara; Schmitt, Fernando; Baltazar, Fátima; Queirós, Odília. "Disruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells". (2021): 10.3390/pharmaceutics13020242 Sousa, Bárbara; Pereira, Joana; Marques, Ricardo; Grilo, Luís F.; Pereira, Susana P.; Sardão, Vilma A.; Schmitt, Fernando; Oliveira, Paulo J.; Paredes, Joana. "P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 12 (2020): 165964. http://dx.doi.org/10.1016/j.bbadis.2020.165964. 10.1016/j.bbadis.2020.165964 Flávia Martins; Rosa Oliveira; Bruno Cavadas; Filipe Pinto; Ana Cardoso; Flávia Castro; Bárbara Sousa; et al. "Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer". Cancers (2020): https://www.mdpi.com/2072-6694/12/4/818. 10.3390/cancers12040818 Bárbara Sousa; Joana Pereira; Joana Paredes. "The Crosstalk Between Cell Adhesion and Cancer Metabolism". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/8/1933. 10.3390/ijms20081933 Ribeiro, Ana Sofia; Nobre, Ana Rita; Mendes, Nuno; Almeida, João; Vieira, André Filipe; Sousa, Bárbara; Carvalho, Filomena A.; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell Communication and Signaling 16 1 (2018): http://dx.doi.org/10.1186/s12964-018-0286-2. 10.1186/s12964-018-0286-2 Hoffmann C; Mao X; Brown-Clay J; Moreau F; Al Absi A; Wurzer H; Sousa B; et al. "Hypoxia promotes breast cancer cell invasion through HIF-1a-mediated up-regulation of the invadopodial actin bundling protein CSRP2.". Scientific reports (2018): http://europepmc.org/abstract/med/29976963. 10.1038/s41598-018-28637-x Figueiredo J; Rodrigues I; Ribeiro J; Fernandes MS; Melo S; Sousa B; Paredes J; Seruca R; Sanches JM. "Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept.". Scientific reports (2018): http://europepmc.org/abstract/med/29980764. 10.1038/s41598-018-28570-z Oliveira P; Carvalho J; Rocha S; Azevedo M; Reis I; Camilo V; Sousa B; et al. "Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation.". (2016): http://europepmc.org/abstract/med/27721458. 10.1038/srep34860 Vieira, A.F.; Ribeiro, A.S.; Dionísio, M.R.; Sousa, B.; Nobre, A.R.; Albergaria, A.; Santiago-Gómez, A.; et al. "P-cadherin signals through the laminin receptor a6ß4 integrin to induce stem cell and invasive properties to basal-like breast cancer cells". Oncotarget 5 3 (2014): 679-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896821980&partnerID=MN8TOARS. Sousa, B.; Ribeiro, A.S.; Nobre, A.R.; Lopes, N.; Martins, D.; Pinheiro, C.; Vieira, A.F.; et al. "The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype". BMC Cancer 14 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84908094892&partnerID=MN8TOARS. 10.1186/1471-2407-14-734 Moniz, S.; Martinho, O.; Pinto, F.; Sousa, B.; Loureiro, C.; Oliveira, M.J.; Moita, L.F.; et al. "Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness". Human Molecular Genetics 22 1 (2013): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871200220&partnerID=MN8TOARS. 10.1093/hmg/dds405 Albergaria, A.; Resende, C.; Nobre, A.R.; Ribeiro, A.S.; Sousa, B.; Machado, J.C.; Seruca, R.; Paredes, J.; Schmitt, F.. "CCAAT/Enhancer Binding Protein ß (C/EBPß) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873547668&partnerID=MN8TOARS. 10.1371/journal.pone.0055749 Ribeiro, A.S.; Sousa, B.; Carreto, L.; Mendes, N.; Nobre, A.R.; Ricardo, S.; Albergaria, A.; et al. "P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model". Journal of Pathology 229 5 (2013): 705-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875054847&partnerID=MN8TOARS. 10.1002/path.4143 Martins, D.; Beça, F.F.; Sousa, B.; Baltazar, F.; Paredes, J.; Schmitt, F.. "Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma Key events in the progression from an in situ to an invasive breast carcinoma". Cell Cycle 12 16 (2013): 2684-2690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883237456&partnerID=MN8TOARS. 10.4161/cc.25794 Lopes, N.; Carvalho, J.; Durães, C.; Sousa, B.; Gomes, M.; Costa, J.L.; Oliveira, C.; Paredes, J.; Schmitt, F.. "1Alpha,25-dihydroxyvitamin D 3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation". Anticancer Research 32 1 PART 2 (2012): 249-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856024024&partnerID=MN8TOARS. Albergaria, A.; Ribeiro, A.-S.; Vieira, A.-F.; Sousa, B.; Nobre, A.-R.; Seruca, R.; Schmitt, F.; Paredes, J.. "P-cadherin role in normal breast development and cancer". International Journal of Developmental Biology 55 7-9 (2011): 811-822. http://www.scopus.com/inward/record.url?eid=2-s2.0-82555201366&partnerID=MN8TOARS. 10.1387/ijdb.113382aa Martins, D.; Sousa, B.; Lopes, N.; Gomes, M.; Veronese, L.; Albergaria, A.; Paredes, J.; Schmitt, F.. "Molecular phenotypes of matched in situ and invasive components of breast carcinomas". Human Pathology 42 10 (2011): 1438-1446. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053182840&partnerID=MN8TOARS. 10.1016/j.humpath.2010.08.024 Pinheiro, C.; Sousa, B.; Albergaria, A.; Paredes, J.; Dufloth, R.; Vieira, D.; Schmitt, F.; Baltazar, F.. "GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression". Histology and Histopathology 26 10 (2011): 1279-1286. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053319008&partnerID=MN8TOARS. Ribeiro, A.S.; Albergaria, A.; Sousa, B.; Correia, A.L.; Bracke, M.; Seruca, R.; Schmitt, F.C.; Paredes, J.. "Extracellular cleavage and shedding of P-cadherin: A mechanism underlying the invasive behaviour of breast cancer cells". Oncogene 29 3 (2010): 392-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149183984&partnerID=MN8TOARS. 10.1038/onc.2009.338 Albergaria, A.; Ribeiro, A.S.; Pinho, S.; Milanezi, F.; Carneiro, V.; Sousa, B.; Sousa, S.; et al. "ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: A role for C/EBPß in CDH3 gene activation". Human Molecular Genetics 19 13 (2010): 2554-2566. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954172745&partnerID=MN8TOARS. 10.1093/hmg/ddq134 Pinheiro, C.; Albergaria, A.; Paredes, J.; Sousa, B.; Dufloth, R.; Vieira, D.; Schmitt, F.; Baltazar, F.. "Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma". Histopathology 56 7 (2010): 860-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953195898&partnerID=MN8TOARS. 10.1111/j.1365-2559.2010.03560.x Sousa, B.; Paredes, J.; Milanezi, F.; Lopes, N.; Martins, D.; Dufloth, R.; Vieira, D.; et al. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: An immunohistochemical study". Histology and Histopathology 25 8 (2010): 963-974. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956895496&partnerID=MN8TOARS. Lopes, N.; Sousa, B.; Martins, D.; Gomes, M.; Vieira, D.; Veronese, L.A.; Milanezi, F.; et al. "Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: A study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions". BMC Cancer 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956478256&partnerID=MN8TOARS. 10.1186/1471-2407-10-483 Ribeiro AS; Carreto LC; Albergaria A; Sousa B; Ricardo S; Milanezi F; Seruca R; et al. "Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?". (2010): http://europepmc.org/abstract/PMC/PMC3255045. Rodrigues, Ligia R.; Lopes, Nair; Sousa, Barbara; Vieira, Daniella; Milanezi, Fernanda; Paulsson, Marie; Lindmark-Mansson, Helena; Teixeira, Jose A.; Schmitt, Fernando. "Significance of Osteopontin Expression in Human Invasive Breast Tumour Stroma". The Open Breast Cancer Journal 1 1 (2009): 1-9. http://dx.doi.org/10.2174/1876817200901010001. 10.2174/1876817200901010001 Lopes, N.; Sousa, B.; Vieira, D.; Milanezi, F.; Schmitt, F.. "Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles". Histopathology 55 5 (2009): 594-599. http://www.scopus.com/inward/record.url?eid=2-s2.0-71049118533&partnerID=MN8TOARS. 10.1111/j.1365-2559.2009.03417.x Albergaria, A.; Paredes, J.; Sousa, B.; Milanezi, F.; Carneiro, V.; Bastos, J.; Costa, S.; et al. "Expression of FOXA1 and GATA-3 in breast cancer: The prognostic significance in hormone receptor-negative tumours". Breast Cancer Research 11 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-74049137968&partnerID=MN8TOARS. 10.1186/bcr2327
Thesis / Dissertation	"P-cadherin-mediated cell-cell adhesion: Its role on immune evasion in metastasis breast cancer". Master, Universidade de Aveiro, 2023. "Joana Sousa Pereira: Targeting anoikis-resistant P-cadherin-enriched breast cancer cells by in vitro metabolic reprograming". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2017. Sousa, Bárbara. "Underlying the role of P-cadherin expression in breast cancer cell metabolism". PhD, 2014. Sousa, Bárbara. "Immunohistochemical characterization of a series of invasive breast carcinomas using Tissue Microarrays". Degree, 2007.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/05/10	P-cadherin-mediated cell-cell adhesion: its role on immune evasion in metastatic breast cancer (co-supervision)	IJUP Edition, Encontro de Investigação Jovem, Porto, Portugal (Porto, Portugal)
2022/05/04	P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer (co-supervision)	15th Encontro de Investigação Jovem da Universidade do Porto (Porto, Portugal)
2021/11/19	P-cadherin as a phenotypic stability factor of the hybrid epithelial/mesenchymal phenotype in breast cancer (co-supervision)	18th National Congress on Oncology, November Sociedade Portuguesa de Oncologia
2019/11	The anti-oxidant activity of P-cadherin promotes metastasis and therapy resistance in breast cancer	8th i3S Annual Meeting (Povoa de Varzim, Portugal)
2019/09	P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems	Oncometabolism: From Conceptual Knowledge to Clinical Applications (Luso, Portugal)
2019/09	The anti-oxidant activity of P-cadherin promotes metastasis and doxorubicin resistance in breast cancer	MAC’19- 6th Biannual Meeting on Mitochondria, Apoptosis & Cancer (Praga, Czech Republic)
2019/01	Circulating CSCs: how to survive upon metabolic alterations caused by matrix detachment	CANCEL STEM Consortium Meeting UC-Biotech, Cantanhede, Portugal (Cantanhede, Portugal)
2018/10	P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative stress	ISCaM 5th annual Meeting- Metabolic Adaptations and targets in Cancer, from International Society of Cancer Metabolism (Bratislava, Slovakia)
2017/10	P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells	10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Covilhã, Portugal)
2017/07	P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells	FEBS ADVANCED LECTURE COURSE ON ONCOMETABOLISM: From Conceptual Knowledge to Clinical Applications (Figueira da Foz, Portugal)
2016/11	P-cadherin: an antioxidant for metabolic defects in breast cancer stem cells	5th I3S Scientific Retreat, IBMC/INEB/IPATIMUP (Povoa de Varzim, Portugal)
2015/10	P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells	7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Lisboa, Portugal)
2014/05	E-cadherin and P-cadherin: their crosstalk in breast cancer cells	5th French Cell Adhesion Club Symposium (Marselha, France)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/07/01 - Current	In vitro 3D breast cancer spheroids: comparison of different cell lines from distinct molecular subtypes (supervision) Supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/01 - Current	P-cadherin-mediated cell-cell adhesion: its role in hybrid E/M phenotype and immune evasion in metastatic breast cancer (co-supervision) Co-supervisor	Patologia e Genética Molecular (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - Current	The role of cell-cell adhesion in the survival of inflammatory breast cancer tumor emboli (co-supervision) Co-supervisor	Patologia e Genética Molecular (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/01 - 2023/09/30	P-cadherin-mediated cell-cell adhesion: its role on immune evasion in metastatic breast cancer (co-supervision) Co-supervisor	Mestrado em Bioquímica Clínica (Master) Universidade de Aveiro, Portugal
2019/01/01 - 2019/06/30	Evaluate the role of P-cadherin in the doxorubicin resistance of breast cancer stem cells (co-supervision) Co-supervisor	Bio-Medical Laboratory Technology bachelor (Degree) Universiteit Gent, Belgium
2016/09 - 2017/09	Targeting anoikis-resistant P-cadherin-enriched Breast Cancer Cells by in vitro Metabolic Reprograming Co-supervisor	Bioquímica (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/01/13 - Current	Ciencia et al- i3s Educational Program Workshop	A Herança dos Maias Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/10/01 - Current	Science Ambassador at i3S Educational Program: Circulating Tumor Cells and Breast Cancer Exhibition	Ciencia et al Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Current	Exposição coletiva de Fotografias “O CANCRO VISTO AO MICROSCÓPIO” Exhibition	Exposição coletiva de Fotografias “O CANCRO VISTO AO MICROSCÓPIO” Universidade de Aveiro, Portugal
2007 - Current	Participation in "Ciência Viva" exhibitions	Ciência Viva, Portugal
2007 - Current	Dissemination of scientific research within an exhibition promoted by University of Porto targeting high school students: MOSTRA UP	MOSTRA UP Universidade do Porto, Portugal
2014/11/14 - 2014/11/15	Ipatimup - 2 Dias Abertos Exhibition	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/05/05 - 2014/05/12	Exposição: Cancro, Ciência e Cidade: Os Passos da Ciência nos Paços do Concelho Meeting	Exposição: Cancro, Ciência e Cidade: Os Passos da Ciência nos Paços do Concelho Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Câmara Municipal do Porto, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/11/30	Tumor spheroids as 3D models to evaluate the efficacy of Azurin-expressing Mesenchymal Stromal Cells-secretome as a potential anticancer therapy (Thesis) Main arguer	Alexandra Amaral Barbosa (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2019 - 2020	Participation in Invasion and Mestatasis module	Medicina (Mestrado integrado)	Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019	Participation in Invasion and Mestatasis module	Medicina (Mestrado integrado)	Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019	Participation in Oncometabolism module at BEB PhD programme	Biologia Experimental e Biomedicina (Doutoramento)	Universidade de Coimbra, Portugal
2017 - 2018	Participation in Oncobiology module in the lesson: Cancer stemness and differentiation	20th GABBA Edition (Curso de doutoramento (conclusão de unidades curriculares))	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018	Participation in Invasion and Mestatasis module	Medicina (Mestrado integrado)	Universidade do Porto Faculdade de Medicina, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2018/02 - 2018/02	Avaliador/Moderador de sessão de comunicações orais no 11º Encontro de Jovens Investigadores da U.PORTO Evaluator

Distinctions

Award

2023	Fulbright award: "Studying the impact of cell-cell adhesion on the metastatic process of Inflammatory Breast Cancer" (co-supervision) Fulbright Portugal, Portugal
2022	Bolsa de Investigação em Oncologia LPCC-NRS 2022 (co-supervision) Liga Portuguesa Contra o Cancro, Portugal
2022	Best Oral Communication at 15th Encontro de Investigação Jovem da Universidade do Porto 2022 (co-supervision)
2021	Best Oral Communication at 18th National Congress on Oncology 2021 (co-supervision)
2012	3rd Award of Oncology poster session in 3rd I3S Scientific Retreat – IBMC/INEB/IPATIMUP, Póvoa de Varzim, Portugal.
2012	Best Poster Award - mTOR expression in basal-like breast cancer and the ability of Everolimus to inhibit the invasion cancer cell capacity (co-author)