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Over the past few years, I have focused on assessing drug immunogenicity within the context of observational clinical studies. During this time, I introduced cutting-edge technologies in our lab to profile patients’ serum anti-drug antibody (ADA) responses and evaluate their impact on PK/PD, efficay and safety of biotherapeutic treated patients. More recently, I have been actively involved in evaluating the developability profiles of biologics during the early preclinical development stage. This work has included utilizing multiplex biophysical tools to characterize the thermal stability, colloidal behavior, size distribution, and binding activity of therapeutic antibody candidates.
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Identification

Personal identification

Full name
Carlos Jorge Trindade Araújo

Citation names

  • Araújo, C
  • Carlos Araújo
  • Trindade, C

Author identifiers

Ciência ID
5910-01C1-D5DF
ORCID iD
0000-0001-5202-6091

Email addresses

  • caraujo@vectorb2b.com (Professional)

Telephones

Telephone
  • 217946486 Ext.: 514516 (Professional)

Addresses

  • Faculdade Farmácia , 1649-003, Lisbon, Lisbon, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2021/10 - 2021/11
Concluded
 Python em Data Science Da Análise de Dados à Tomada de Decisão (Outros)
GADES SOLUTIONS, Portugal

Universidade de Lisboa Centro de Estatística e Aplicações, Portugal
2014/02/10
Concluded
 Master in Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007/05 - 2007/05
Concluded
 IGC Animal Use Practical Course on Laboratory Rodent Handling and Procedures (Outros)
Federation of European Laboratory Animal Science Associations, Belgium
2003/06/05
Concluded
 Biologia ramo científico (Licenciatura)
Universidade de Évora, Portugal
Affiliation

Science

Category
Host institution 		Employer
2021/08/01 - Current Researcher (Research) VectorB2B Drug Developing, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/12/04 - 2021/07/31 Research Assistant (Research) Associação para o Desenvolvimento do Ensino e Investigação da Microbiologia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projects

Grant

Designation Funders
2017/12/04 - 2021/07/31 Immunogenicity in Fabry disease: the role of enzyme replacement therapy
PRT-001425
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Shire Human Genetic Therapies SA
Ongoing
2020/06/22 - 2020/12/22 Rapid assessment on Covid-19 disease severity and COV-SARS-2 immunity by infrared spectroscopy
613409300
uidb/04138/2020
Researcher
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Concluded
2009/09/01 - 2015/09/30 Molecular pathogenesis of “cis-ruption” diseases associated with chromosome translocations
PTDC/SAL-GMG/118140/2010
Research Technician Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Concluded
Outputs

Publications

Book chapter
  1. David, Dezso; Almeida, Lígia S.; Maggi, Maristella; Araújo, Carlos; Imreh, Stefan; Valentini, Giovanna; Fekete, György; Haltrich, Irén. "Clinical Severity of PGK1 Deficiency Due To a Novel p.E120K Substitution Is Exacerbated by Co-inheritance of a Subclinical Translocation t(3;14)(q26.33;q12), Disrupting NUBPL Gene". In JIMD Reports, Volume 23, 55-65. Springer Berlin Heidelberg, 2015.
    10.1007/8904_2015_427
Conference abstract
  1. Palma, Carolina Santos; Simão, André Lopes; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "OC10: “Cirrhosis Is Associated With Lower Serological Responses To COVID-19 Vaccines In Patients With Chronic Liver Disease". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting, Faculty of pharmacy Lisbon., Lisbon, 2023.
    Published
  2. Palma, Carolina Santos; André L. Simão; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "Presence of cirrhosis in chronic liver patients associated with a lower immune response to COVID-19 vaccines – a multicenter European study". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon., Lisbon, 2022.
    Published
  3. Aguiar, Patricio; Araújo, Carlos; Azevedo, Olga; Soares, José Luís Ducla; Hughes, Derralynn; Gonçalves, João. "Cell-mediated immunity in Fabry disease patients submitted to enzyme replacement therapy". Paper presented in WORLD Symposium™ 2019 Introduction. Mol Genet Metab., 2020.
    Published • 10.1016/j.ymgme.2019.11.016
  4. David, Dezso; Anand, Deepti; Araújo, C; Gloss, Brian; Fino, Joana; Marques, Barbara. "CC7: Identification of two candidate genes OAF and PVRL1 for Peters anomaly and ectopia lentis.". Paper presented in 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana, Coimbra, 2016.
    Published
  5. Barbara Marques; Cristina Ferreira; Araújo, C; Luis Antonio de Almeida Vieira; M Martins; M Pinto; David, Dezso. "P90: Tricho-rhino-phalangeal syndrome type I as a "cis-ruption disorder" caused by a translocation.". Paper presented in 8th E.C.A. Conference - Chromosome Research, Porto, 2011.
Conference paper
  1. Marques, Bárbara; Ferreira, Cristina; Araújo, Carlos; Vieira, Luís; Martins, Márcia; Pinto, Maximina; Dias, Cristina; David, Dezso. "Tricho-rhino-phalangeal syndrome type I as a “cis-ruption disorder” caused by a translocation". 2011.
Conference poster
  1. Carlos Araújo; Laura Marin; GONÇALVES, JOAO; Kris Ver Donck. Corresponding author: Carlos Araújo. "Ressonância Plasmónica de Superficie em fibra óptica para medir diretamente no plasma a concentração sérica de anticorpos terapêuticos e anticorpos antifármaco". Paper presented in Congresso Nacional Dos Farmacêuticos 2024, 2024.
    10.25756/rpf.v15i3-4.315
  2. Araújo, C; Laura Marin; Florian bossard; Azevedo, Olga M. ; Aguiar, Patricio; Goncalves, Joao. "Fiber-Optic Surface Plasmon Resonance based assay to measure directly serum concentration of therapeutic antibodies and anti-drug antibodies.". Paper presented in 15th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon, 2024.
  3. Araújo, C; Ioannou, A; Azevedo, O; Aguiar, Patricio; GONÇALVES, JOAO. Corresponding author: Araújo, C. "Microfluidic Antibody Affinity Profiling of Serum Anti-Drug Antibodies - A Novel Approach to Analyze in depth Drug Immunogenicity". Paper presented in Simpósio Científico "O Futuro Hoje: Novas Terapêuticas Moleculares e Biológicas" SRSRA-OF, 2023.
  4. Araújo, C; Ioannou, A; Azevedo, Olga M. ; Aguiar, Patricio; Goncalves, Joao. "P068: Microfluidic Antibody Affinity Profiling of Serum Anti-Drug Antibodies A New approach to analyze in depth drug immunogenicity.". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting, Faculty of pharmacy Lisbon., 2023.
  5. André L. Simão. Corresponding author: André L. Simão. "Presence of cirrhosis in chronic liver disease patients associates with a lower immune response to COVID-19 vaccines-a multicenter european study". Paper presented in EASL, 2022.
  6. Araújo, C; Palma, Carolina; Igor casado; Fontes, Pedro; Goncalves, Joao. "P076: Induction of neutralizing antibody protection against SARS-CoV-2 Delta and Omicron variants following mRNA booster (BNT162b2) dose in cohorts of Portuguese subjects.". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon., 2022.
  7. Henrique, Mariana Moura; André L. Simão; Palma, Carolina; A. P. Alves; Araújo, C; Goncalves, Joao; Caeiro F; Castro, Rui. "P70: Reduced humoral imune response of liver transplanted recipients to COVID-19 vaccines". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon., 2022.
  8. Casado I; Palma, Carolina Santos; Trindade C; Goncalves, Joao. "P076: Characterization of Immunogenicity produced by COVID-19 vaccines in autoimmune arthritic diseases.". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon., 2022.
  9. Araújo, C; Aguiar, Patricio; Azevedo, Olga M. ; Goncalves, Joao. "Immunogenicity in Fabry disease: the role of enzyme replacement therapy.". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon, 2019.
  10. David, Dezso; Anand, Deepti; Araújo, Carlos; Gloss, Brian; Fino, Joana; Marques, Bárbara; Dinger, Marcel; et al. "Identification of two new candidate genes OAF and PVRL1 for Peters anomaly and ectopia lentis". Paper presented in 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2016.
  11. Dezso David; Haltrich, Irén; Maggi, Maristella; Almeida, Leopoldina Maria da Costa; Carlos Araújo; Marques, Barbara; Valentini, Giovanna; Imreh, Stefan; Fekete, György. "Clinically severe PGK1 deficiency due to the novel c.358G>A mutation is probably exacerbated in t(3;14)(q26.33;q12) carriers by disruption of complex I assembly factor NUBPL.". Paper presented in Congresso Jubilar da Sociedade Húngara de Genética Humana, Budapest, Formação médica LXXXIX/4, 2014.
Journal article
  1. Acúrcio, Rita C.; Kleiner, Ron; Vaskovich-Koubi, Daniella; Carreira, Bárbara; Liubomirski, Yulia; Palma, Carolina; Yeheskel, Adva; et al. "Intranasal Multiepitope PD-L1-siRNA-Based Nanovaccine: The Next-Gen COVID-19 Immunotherapy". Advanced Science (2024): http://dx.doi.org/10.1002/advs.202404159.
    Published • 10.1002/advs.202404159
  2. Harris, Clare; Harris, Richard James; Young, David; McDonnell, Martin; Clancy, Bridget; Harvey, Justin; Araujo, Carlos; et al. "Clinical Outcomes and Patient Experience of Biosimilar to Biosimilar Infliximab Switching in Patients with Inflammatory Bowel Disease: A Prospective, Single-Centre, Phase IV Interventional Study with a Nested Qualitative Study". GastroHep 2023 (2023): 1-14. http://dx.doi.org/10.1155/2023/1248526.
    10.1155/2023/1248526
  3. Brás, R.; Goncalves, J.; Araújo, C.; Godinho Santos, A.; Costa, L.; Pedro, E.; Caiado, J.. "sIgE/sIgG4 profile in platinum desensitization: is there immunological tolerance?". European Annals of Allergy and Clinical Immunology online fir (2023): https://doi.org/10.23822/eurannaci.1764-1489.302.
    10.23822/eurannaci.1764-1489.302
  4. Simão, André Lopes; Palma, Carolina Santos; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease". JHEP Reports (2023): 100697. http://dx.doi.org/10.1016/j.jhepr.2023.100697.
    10.1016/j.jhepr.2023.100697
  5. Borrega, Rodrigo; Araújo, Carlos; Aguiam, Nádia; Magro, Fernando; Fonseca, João Eurico; Danese, Silvio; Lopes, João; Goncalves, Joao. "Systematic Review and Principal Components Analysis of the Immunogenicity of Adalimumab". BioDrugs (2020): http://dx.doi.org/10.1007/s40259-020-00458-3.
    10.1007/s40259-020-00458-3
  6. David, Dezso; Anand, Deepti; Araújo, Carlos; Gloss, Brian; Fino, Joana; Dinger, Marcel; Lindahl, Päivi; et al. "Identification of OAF and PVRL1 as candidate genes for an ocular anomaly characterized by Peters anomaly type 2 and ectopia lentis". Experimental Eye Research 168 (2018): 161-170. http://dx.doi.org/10.1016/j.exer.2017.12.012.
    10.1016/j.exer.2017.12.012
  7. David, Dezso; Marques, Bárbara; Ferreira, Cristina; Araújo, Carlos; Vieira, Luís; Soares, Gabriela; Dias, Cristina; Pinto, Maximina. "Co-segregation of trichorhinophalangeal syndrome with a t(8;13)(q23.3;q21.31) familial translocation that appears to increase TRPS1 gene expression". Human Genetics 132 11 (2013): 1287-1299. http://dx.doi.org/10.1007/s00439-013-1333-0.
    10.1007/s00439-013-1333-0
Online resource
  1. Araújo, C; Laura Marin; Goncalves, Joao; Kris Ver Donck. Corresponding author: Araújo, C. Dip-in biosensor to accurately measure monoclonal antibodies in blood plasma. 2024. https://foxbiosystems.com/publications/white-paper-wp11-dip-in-biosensor-to-accurately-measure-monoclonal-antibodies-in-blood-plasma/.
Thesis / Dissertation
  1. "Araújo, C; "Molecular characterization of a balanced [t(11;18)(q23.3;q11.2)dn)] translocation associated with a syndromic form of Peter´s anomaly and ectopia lentis" NOVA FCT, (2014).". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2014.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015 Molecular characterization of a de novo balanced [t(11;18)(q23.3;q11.2)] translocation associated with a syndromic form of Peter´s anomaly and ectopia lentis. Seminários no departamento de Genética Humana
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisbon, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2013 - Current Attendance
Seminar
 Next-generation sequencing meeting: applications in genetic and infectious diseases
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2012/10 - 2012/10 Internal training with title: Disclosure of the Ethics Committee
Conference
 Disclosure of the Ethics Committee
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2012/04 - 2012/04 Celebration day of human genetic department and their research activities
Conference
 Day of the Department of Human Genetics
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2011/03 - 2011/03 Formação interna
Conference
 Internal training action "DG Health and Safety Manual" - INSA training office I.P.
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2007 - 2007 Attendance
Workshop
 Behaviour Pathologies: Biological Approaches
Instituto Gulbenkian de Ciência, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/07/02 - 2024/07/02 Advanced Course on Fragment Based Drug Design (FBDD) Hand-on Session using SPR: Working with Proteins (Pós-Graduação) Faculty of pharmacy Lisbon, Portugal
2024/05 - 2024/05 Drug Immunogenicity Assessment with Bridging LBA Format - Experimental Session Research & Development of Biotherapeutic Drugs (Mestrado) Faculty of pharmacy Lisbon, Portugal

Mentoring / Tutoring

Topic Student name
2022/01/01 - 2023/01/01 Characterization of Immunogenicity produced by BNT162b2 mRNA COVID-19 Vaccine in Rheumatoid Arthritis Patients Igor André de Sousa Casado
2020/06 - 2021/12 Isolation of Human Recombinant Antibodies Anti-SARS-CoV-2 by Synthetic Methods Pedro Coelho
2020/05 - 2021/12 Evaluation of Immune Response to SARS-CoV-2 in ICU Patientes with COVID-19 Carolina Palma
2020/09 - 2021/06 Immunogenicity in Fabry Disease: The role of Enzyme Replacement Therapy Célia Isabel dos Santos Pedro
2021/03 - 2021/05 Evaluation of immunogenicity to Agalsidase in Fabry Disease Mariana da Silva Baptista Godinho
Distinctions

Other distinction

2018 Research fellowship - IIR-PRT-001425
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Shire Pharmaceuticals Human Genetic Therapies Inc, United States
2014 Research fellowship - PTDC/SAL-GMG/118140/2010
Associação para a Inovação e Desenvolvimento da FCT, Portugal
2009 Research fellowship - BRJ/01/DG/2009
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal