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Carlos Jorge Trindade Araújo. Completed the Mestrado in Genética Molecular e Biomedicina in 2014/02/10 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia and Licenciatura in Biologia ramo Científico in 2003/06/05 by Universidade de Évora. Is Researcher in Universidade de Lisboa Instituto de Investigação do Medicamento and Researcher in VectorB2B. Published 4 articles in journals. Has 1 section(s) of books. Participated in 2 event(s). Has received 5 awards and/or honors. Participates and/or participated as Other in 1 project(s), Research Technician Fellow in 3 project(s) and Researcher in 2 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology.
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Identification

Personal identification

Full name
Carlos Jorge Trindade Araújo

Citation names

  • Araújo, C

Author identifiers

Ciência ID
5910-01C1-D5DF
ORCID iD
0000-0001-5202-6091

Email addresses

  • carlosaraujo@adeim.pt (Professional)

Telephones

Mobile phone
  • 967035420 (Personal)

Addresses

  • Avenida Gama Pinto, 1600, Lisbon, Lisbon, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1)
Education
Degree Classification
2014/02/10
Concluded
 Master in Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Molecular characterization of a balanced [t(11;18)(q23.3;q11.2)dn)] translocation associated with a syndromic form of Peter´s anomaly and ectopia lentis" (THESIS/DISSERTATION)
2003/06/05
Concluded
 Biologia ramo científico (Licenciatura)
Universidade de Évora, Portugal
"Estudo sobre potencial imunização com vacinas de DNA e proteínas recombinantes contra o vírus da peste suína africana" (THESIS/DISSERTATION)
 14 ou of 20
Affiliation

Science

Category
Host institution 		Employer
2021/08/01 - Current Researcher (Research) VectorB2B, Portugal
iMed - Research Institute for Medicines, Portugal
(...)
2017/12/04 - 2021/07/31 Research Assistant (Research) Associação para o Desenvolvimento do Ensino e Investigação da Microbiologia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projects

Grant

Designation Funders
2020/06/22 - 2020/12/22 Rapid assessment on Covid-19 disease severity and COV-SARS-2 immunity by infrared spectroscopy
613409300
uidb/04138/2020
Researcher
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Ongoing
2011 - 2015 Molecular pathogenesis of “cis-ruption” diseases associated with chromosome translocations
PTDC/SAL-GMG/118140/2010
Research Technician Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Concluded
2006/07 - 2008/02 Role of microglia activation in animal models of neurodegenerative diseases
POCI/SAU-NEU/56986/2004
Research Technician Fellow
Instituto Gulbenkian de Ciência, Portugal
Concluded
2005 - 2006 Potential application of evasive viral genes that modulates host immune response
MGI/36403/99
Trainee
Concluded

Contract

Designation Funders
2018/08 - 2020/07 Immunogenicity in Fabry disease: the role of enzyme replacement therapy
PRT-001425
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Shire Human Genetic Therapies SA
Ongoing

Other

Designation Funders
2009/09 - 2011/09 Identification of novel genes associated with chromosome anomalies and characterization of molecular pathogenesis
BRJ/01/DG/2009
Research Technician Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Concluded
Outputs

Publications

Book chapter
  1. David, Dezso; Almeida, Lígia S.; Maggi, Maristella; Araújo, Carlos; Imreh, Stefan; Valentini, Giovanna; Fekete, György; Haltrich, Irén. "Clinical Severity of PGK1 Deficiency Due To a Novel p.E120K Substitution Is Exacerbated by Co-inheritance of a Subclinical Translocation t(3;14)(q26.33;q12), Disrupting NUBPL Gene". In JIMD Reports, Volume 23, 55-65. Springer Berlin Heidelberg, 2015.
    10.1007/8904_2015_427
Conference paper
  1. David, Dezso; Anand, Deepti; Araújo, Carlos; Gloss, Brian; Fino, Joana; Marques, Bárbara; Dinger, Marcel; et al. "Identification of two new candidate genes OAF and PVRL1 for Peters anomaly and ectopia lentis". 2017.
  2. Marques, Bárbara; Ferreira, Cristina; Araújo, Carlos; Vieira, Luís; Martins, Márcia; Pinto, Maximina; Dias, Cristina; David, Dezso. "Tricho-rhino-phalangeal syndrome type I as a “cis-ruption disorder” caused by a translocation". 2011.
Conference poster
  1. Araújo, C; Ioannou, A; Azevedo, O; Aguiar, Patricio; Goncalves, J. Corresponding author: Araújo, C. "Microfluidic Antibody Affinity Profiling of Serum Anti-Drug Antibodies - A Novel Approach to Analyze in depth Drug Immunogenicity". Paper presented in O Futuro Hohe: Novas Terapêuticas Moleculares e Biológicas, 2023.
  2. André L. Simão. Corresponding author: André L. Simão. "Presence of cirrhosis in chronic liver disease patients associates with a lower immune response to COVID-19 vaccines-a multicenter european study". Paper presented in EASL, 2022.
Journal article
  1. Acúrcio, Rita C.; Kleiner, Ron; Vaskovich-Koubi, Daniella; Carreira, Bárbara; Liubomirski, Yulia; Palma, Carolina; Yeheskel, Adva; et al. "Intranasal Multiepitope PD-L1-siRNA-Based Nanovaccine: The Next-Gen COVID-19 Immunotherapy". Advanced Science (2024): http://dx.doi.org/10.1002/advs.202404159.
    Published • 10.1002/advs.202404159
  2. Harris, Clare; Harris, Richard James; Young, David; McDonnell, Martin; Clancy, Bridget; Harvey, Justin; Araujo, Carlos; et al. "Clinical Outcomes and Patient Experience of Biosimilar to Biosimilar Infliximab Switching in Patients with Inflammatory Bowel Disease: A Prospective, Single-Centre, Phase IV Interventional Study with a Nested Qualitative Study". GastroHep 2023 (2023): 1-14. http://dx.doi.org/10.1155/2023/1248526.
    10.1155/2023/1248526
  3. Simão, André Lopes; Palma, Carolina Santos; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease". JHEP Reports (2023): 100697. http://dx.doi.org/10.1016/j.jhepr.2023.100697.
    10.1016/j.jhepr.2023.100697
  4. Borrega, Rodrigo; Araújo, Carlos; Aguiam, Nádia; Magro, Fernando; Fonseca, João Eurico; Danese, Silvio; Lopes, João; Goncalves, Joao. "Systematic Review and Principal Components Analysis of the Immunogenicity of Adalimumab". BioDrugs (2020): http://dx.doi.org/10.1007/s40259-020-00458-3.
    10.1007/s40259-020-00458-3
  5. Aguiar, Patricio; Araújo, Carlos; Azevedo, Olga; Soares, José Luís Ducla; Hughes, Derralynn; Gonçalves, João. "Cell-mediated immunity in Fabry disease patients submitted to enzyme replacement therapy". Molecular Genetics and Metabolism 129 2 (2020): S18. http://dx.doi.org/10.1016/j.ymgme.2019.11.016.
    10.1016/j.ymgme.2019.11.016
  6. David, Dezso; Anand, Deepti; Araújo, Carlos; Gloss, Brian; Fino, Joana; Dinger, Marcel; Lindahl, Päivi; et al. "Identification of OAF and PVRL1 as candidate genes for an ocular anomaly characterized by Peters anomaly type 2 and ectopia lentis". Experimental Eye Research 168 (2018): 161-170. http://dx.doi.org/10.1016/j.exer.2017.12.012.
    10.1016/j.exer.2017.12.012
  7. David, Dezso; Marques, Bárbara; Ferreira, Cristina; Araújo, Carlos; Vieira, Luís; Soares, Gabriela; Dias, Cristina; Pinto, Maximina. "Co-segregation of trichorhinophalangeal syndrome with a t(8;13)(q23.3;q21.31) familial translocation that appears to increase TRPS1 gene expression". Human Genetics 132 11 (2013): 1287-1299. http://dx.doi.org/10.1007/s00439-013-1333-0.
    10.1007/s00439-013-1333-0
Online resource
  1. Araújo, C. Corresponding author: Araújo, C. Dip-in biosensor to accurately measure monoclonal antibodies in blood plasma. 2024. https://foxbiosystems.com/publications/white-paper-wp11-dip-in-biosensor-to-accurately-measure-monoclonal-antibodies-in-blood-plasma/.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015 Molecular characterization of a de novo balanced [t(11;18)(q23.3;q11.2)] translocation associated with a syndromic form of Peter´s anomaly and ectopia lentis. Seminários no departamento de Genética Humana
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisbon, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2013 - Current Attendance
Seminar
 Next-generation sequencing meeting: applications in genetic and infectious diseases
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2007 - 2007 Attendance
Workshop
 Behaviour Pathologies: Biological Approaches
Instituto Gulbenkian de Ciência, Portugal

Consulting

Activity description Institution / Organization
2021/08/01 - Current Biologics`s immunogenicity quantification using biophysical tools. Specifically, determination of binding kynetics, affinity and concentration of polyclonal anti-drug antibody response as key variables to study in depth immunogenicity. Data analytics to understand which patients are prone to develop impactful ADA on efficacy of enzyme replacement therapies and also on hypersensitive adverse events mediated by anti-drug IgEs. VectorB2B, Portugal

iMed - Research Institute for Medicines, Portugal
2020 - 2020 Technical and scientific consulting regarding the role of immune response against COVID-19. Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020 - 2020 Technical and scientific consultancy regarding the development of immunoassays to detect and quantify antibody responses to different antigens of Sars-CoV-2. Analysis of Cytokine profiling in a cohort of severe COVID-19 patients Development of neutralizing antibody assay technology to characterize the humoral immune response against Sars-CoV-2.

Mentoring / Tutoring

Topic Student name
2020/05/01 - 2020/10 Master in Pharmaceutical Biotechnology Carolina Santos Palma
Distinctions

Other distinction

2018 Research fellowship - IIR-PRT-001425
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Shire Pharmaceuticals Human Genetic Therapies Inc, United States
2014 Research fellowship - PTDC/SAL-GMG/118140/2010
Associação para a Inovação e Desenvolvimento da FCT, Portugal
2009 Research fellowship - BRJ/01/DG/2009
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006 Research fellowship
Instituto Gulbenkian de Ciência, Portugal
2004 Research fellowship
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal