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Identification

Personal identification

Full name
Maria Manuel Duque Vieira Marques dos Santos

Citation names

  • Santos, Maria M. M.

Author identifiers

Ciência ID
5910-2BF6-5F65
ORCID iD
0000-0002-2239-9353

Email addresses

  • mariasantos@ff.ulisboa.pt (Professional)

Telephones

Telephone
  • (+351) 217946451 (Professional)

Addresses

  • Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa. Avenida Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
Education
Degree Classification
2021 - 2022
Concluded
 Pedagogia do Ensino Superior (Pós-Graduação)
Universidade de Lisboa Instituto da Educação, Portugal
2000 - 2004
Concluded
 Chemistry (Organic Synthesis) (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Staurosporine and Analogs - Synthesis of Advanced Precursors" (THESIS/DISSERTATION)
1994 - 1999
Concluded
 Applied Chemistry - Organic chemistry (Licenciatura)
Universidade Nova de Lisboa, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2019/06/15 - 2020/12/30 Principal Investigator (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/12/16 - 2018/12/15 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/04 - 2015/04 Visiting Researcher (Research) Université Nice Sophia Antipolis - Institute of chemistry, France
2008/05/02 - 2013/05/01 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/02/01 - 2008/04/30 Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2004/02/01 - 2006/01/31 Postdoc (Research) Universitat de Barcelona Facultat de Farmacia, Spain
2000/01 - 2004/01 Research Trainee (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1999/09 - 1999/12 Visiting Researcher (Research) Laboratory of Molecular Catalysis, University Paris-Sud XI , France

Teaching in Higher Education

Category
Host institution 		Employer
2023/06 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/01 - 2023/06 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2021/03/29 - Current Targeting mutant p53 with tryptophanol-derived small molecules (Funding: 249.956,25)
PTDC/QUI-QOR/1304/2020
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2026 ITN "Protease-guided tumor targeting tools to revolutionize cancer diagnosis and treatment" (Funding: 2,331,266.4 )
101073231
Supervisor
European Commission
2019 - 2022 Bilateral Action Portugal-Hungary, Design and synthesis of hybrid compounds with enhanced anti-tumor potential
SASHJa
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022 Tackling multidrug resistance in cancer: plant-derived lead compounds as P-glycoptrotein (P-gp) and breast cancer resistant protein (BCRP) modulators and collateral sensitivity agents
PTDC/MED-QUI/30591/2017
Researcher
Fundação para a Ciência e a Tecnologia
Cancelled
2018 - 2022 Drug discovery for p53 PPI-targets
PTDC/QUI-QOR/29664/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022 A new approach to fight tuberculosis: co-drugs activated by mycobacterial esterases
PTDC/SAU-INF/28080/2017
Researcher
Fundação para a Ciência e a Tecnologia
Cancelled
2016 - 2019 Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
Researcher
Fundação para a Ciência e Tecnologia
Cancelled
2015 - 2018 New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer
PTDC/BIM-MEC/0895/2014
Researcher
Fundação para a Ciência e Tecnologia
Cancelled
2011 - 2014 Functional, molecular and pharmacological studies of p53 family proteins: from yeast to human cells
110848
Provided by PTCRIS: 110848
 Fundação para a Ciência e a Tecnologia
2011 - 2014 Enantioselective synthesis of indole alkaloids and their application as NMDA antagonists
111664
Provided by PTCRIS: 111664
 Fundação para a Ciência e a Tecnologia
2010 - 2014 Diterpenes as lead compounds for overcoming multidrug resistance in cancer cells: P-glycoprotein modulators and antiproliferative agents
99815
Provided by PTCRIS: 99815
 Fundação para a Ciência e a Tecnologia
2011 - 2013 Bilateral Action Portugal-Spain, Enantioselective synthesis of indole alkaloids from chiral lactams
E07/11
Principal investigator
Concluded

Contract

Designation Funders
2022/04 - 2023/09 Potencial de derivados de ácido nitrobenzóico como fármacos antituberculose. Insights sobre o mecanismo de ação.
Provided by PTCRIS: EXPL/SAU-INF/1097/2021
EXPL/SAU-INF/1097/2021
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2013/07/01 - 2016/02/29 Optimização de moduladores da glicoproteína-P e investigação do mecanismo de efluxo
PTDC/QEQ-MED/0905/2012
Universidade da Madeira, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Santos, Maria Manuel Duque Vieira Marques dos; Lopes, Elizabeth A.. "Synthesis of spirooxindoles by multicomponent reactions". In Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, edited by Faisca Phillips, AMMM, 225-247. Wiley, 2021.
    Published
  2. Lopes, Elizabeth A.; Santos, Maria M. M.; Mori, Mattia. "Pharmacological Treatment of Malaria". In Antiprotozoal Drug Development and Delivery, edited by Surupan, Claudiu; Vermelho, A. B., 219-240. Springer International Publishing, 2021.
    10.1007/7355_2021_125
  3. Espadinha, Margarida; Conway, Stuart J.; Santos, Maria M.M.. "PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors". In Small Molecule Drug Discovery, edited by Trabocchi, A.; Lenci, E., 267-288. Elsevier, 2020.
    10.1016/b978-0-12-818349-6.00010-8
  4. Dourado, Jorge; Perez, Maria; Griera, Rosa; Santos, Maria M. M.. "Asymmetric Cyclocondensation Reaction Induced by Chiral Auxiliary". 198-201. Royal Society of Chemistry, 2016.
    Published
  5. Ribeiro, Carlos J. A.; Moreira, Rui; Santos, Maria M. M.. "Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition". 681-684. Royal Society of Chemistry, 2016.
    Published
  6. Lopes, F.; Santos, M.M.M.; Moreira, R.. "Designing covalent inhibitors: A medicinal chemistry challenge". In Small Molecule Drug Discovery. 2015.
    10.1515/9783110468755-002
  7. Santos, Maria M. M.; Santos, Maria M. M.. "Tryptophanol-Derived Oxazolopiperidone Lactams: Valuable Building Blocks for the Enantioselective Synthesis of Piperidine-Containing Alkaloids". 69-82. Sem local: Research Signpost, 2011.
    Published
Conference abstract
  1. Loureiro, Joana B.; Ribeiro, Rita; Nazareth, Nair; Ferreira, Tiago; Quaresma, Adelina; Barcherini, Valentina; Marabini, Laura; et al. "Abstract P030: Chemoprevention by the mutant p53 reactivator SLMP53-2 on ultraviolet radiation-induced skin cancer". 2021.
    Published • 10.1158/1535-7163.targ-21-p030
Journal article
  1. Cláudia Bento; Marianna Katz; Maria M. M. Santos; Carlos A. M. Afonso. "Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol". Organic Process Research & Development (2024): https://doi.org/10.1021/acs.oprd.3c00428.
    10.1021/acs.oprd.3c00428
  2. Elizabeth A. Lopes; Maria M. M. Santos; Mattia Mori. "Antimalarial drugs: what’s new in the patents?". Expert Opinion on Therapeutic Patents (2023): https://doi.org/10.1080/13543776.2023.2203814.
    10.1080/13543776.2023.2203814
  3. Maria M. M. Santos; Ricardo Ferreira; Paulo Anastácio F. Pacheco. Corresponding author: Maria M. M. Santos. "Reativação da p53 Usando Pequenas Moléculas para Terapia Anticancerígena". Boletim da Sociedade Portuguesa de Química 47 (2023): 30-36. http://dx.doi.org/10.52590/m3.p705.a30002636.
    10.52590/m3.p705.a30002636
  4. Valentina Barcherini; Joana B. Loureiro; Ana Sena; Catarina Madeira; Paula Leandro; Lucília Saraiva; Alexandra M. M. Antunes; Maria M. M. Santos. Corresponding author: Maria M. M. Santos. "Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators". Pharmaceuticals (2023): https://doi.org/10.3390/ph16020146.
    10.3390/ph16020146
  5. Girst, Gábor; Lopes, Elizabeth A.; Gonçalves, Lídia M.; Espadinha, Margarida; Kúsz, Norbert; Wang, Hui-Chun; Santos, Maria M. M.; Hunyadi, Attila. Corresponding author: Santos, Maria M. M.. "Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells". RSC Medicinal Chemistry 14 9 (2023): 1778-1786. http://dx.doi.org/10.1039/d3md00251a.
    10.1039/d3md00251a
  6. Espadinha, Margarida; Lopes, Elizabeth A.; Marques, Vanda; Amaral, Joana D.; dos Santos, Daniel J.V.A.; Mori, Mattia; Daniele, Simona; et al. Corresponding author: Santos, Maria M.M.. "Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors". European Journal of Medicinal Chemistry 241 (2022): 114637. http://dx.doi.org/10.1016/j.ejmech.2022.114637.
    Published • 10.1016/j.ejmech.2022.114637
  7. Lopes, Elizabeth A.; Mestre, Raquel; Fontinha, Diana; Legac, Jenny; Pei, Jinxin V.; Sanches-Vaz, Margarida; Mori, Mattia; et al. "Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity". European Journal of Medicinal Chemistry (2022): 114324. http://dx.doi.org/10.1016/j.ejmech.2022.114324.
    10.1016/j.ejmech.2022.114324
  8. Paulo A. F. Pacheco; Maria M. M. Santos. "Recent Progress in the Development of Indole-Based Compounds Active against Malaria, Trypanosomiasis and Leishmaniasis". Molecules (2022): https://doi.org/10.3390/molecules27010319.
    10.3390/molecules27010319
  9. Loureiro, Joana B.; Ribeiro, Rita; Nazareth, Nair; Ferreira, Tiago; Lopes, Elizabeth A.; Gama, Adelina; Machuqueiro, Miguel; et al. "Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis". Pharmacological Research 175 (2022): 106026. http://dx.doi.org/10.1016/j.phrs.2021.106026.
    10.1016/j.phrs.2021.106026
  10. Joana Loureiro; Raimundo L; Juliana Calheiros; Carla Carvalho; Valentina Barcherini; Nuno Lima; Célia Gomes; et al. "Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance". Cancers (2021): https://www.mdpi.com/2072-6694/13/7/1648.
    10.3390/cancers13071648
  11. Margarida Espadinha; Valentina Barcherini; Lídia M. Gonçalves; Elies Molins; Alexandra M. M. Antunes; Maria M. M. Santos. "Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma". Pharmaceuticals 14 3 (2021): 208-208. https://doi.org/10.3390/ph14030208.
    10.3390/ph14030208
  12. Luís R. Raposo; Ana Silva; Dário Silva; Catarina Roma-Rodrigues; Margarida Espadinha; Pedro V. Baptista; Maria M.M. Santos; Alexandra R. Fernandes. "Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line". Bioorganic & Medicinal Chemistry 30 (2021): 115880-115880. https://doi.org/10.1016/j.bmc.2020.115880.
    10.1016/j.bmc.2020.115880
  13. Barcherini, Valentina; Almeida, Joana; Lopes, Elizabeth; Wang, Mi; Silva, Diogo; Mori, Mattia; Wang, Shaomeng; Saraiva, Lucilia; Santos, Maria M. M.. "Potency and selectivity optimization of tryptophanol-derived oxazoloisoindolinones: novel p53 activators in human colorectal cancer". ChemMedChem (2020): http://dx.doi.org/10.1002/cmdc.202000522.
    10.1002/cmdc.202000522
  14. Espadinha, Margarida; Viejo, Lucía; Lopes, Ricardo M.R.M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J.V.A.; Gonçalves, Lídia; et al. "Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders". European Journal of Medicinal Chemistry 194 (2020): 112242. http://dx.doi.org/10.1016/j.ejmech.2020.112242.
    10.1016/j.ejmech.2020.112242
  15. Helena Ramos; Juliana Calheiros; Joana Almeida; Valentina Barcherini; Sónia Santos; Alexandra T. P. Carvalho; Maria M.M. Santos; Lucília Saraiva. "SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner". International Journal of Molecular Sciences 21 2 (2020): 596-596. https://doi.org/10.3390/ijms21020596.
    10.3390/ijms21020596
  16. Lopes, Elizabeth A.; Gomes, Sara; Saraiva, Lucília; Santos, Maria M.M.. "Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment". Current Medicinal Chemistry 26 41 (2020): 7323-7336. http://dx.doi.org/10.2174/0929867325666181116124308.
    10.2174/0929867325666181116124308
  17. Gomes, Ana Sara; Ramos, Helena; Gomes, Sara; Loureiro, Joana B.; Soares, Joana; Barcherini, Valentina; Monti, Paola; et al. "SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations". Biochimica et Biophysica Acta (BBA) - General Subjects 1864 1 (2020): 129440. http://dx.doi.org/10.1016/j.bbagen.2019.129440.
    10.1016/j.bbagen.2019.129440
  18. Gomes, Sara; Bosco, Bartolomeo; Loureiro, Joana B.; Ramos, Helena; Raimundo, Liliana; Soares, Joana; Nazareth, Nair; et al. "SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma". Cancers 11 8 (2019): 1151. http://dx.doi.org/10.3390/cancers11081151.
    10.3390/cancers11081151
  19. Amaral, Joana D.; Silva, Dário; Rodrigues, Cecília M. P.; Solá, Susana; Santos, Maria M. M.. "A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation". Frontiers in Chemistry 7 (2019): http://dx.doi.org/10.3389/fchem.2019.00015.
    10.3389/fchem.2019.00015
  20. Margarida Espadinha; Nuno M. T. Lourenço; Luis Sobral; Rafael Antunes; Maria M. M. Santos. "A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide". ChemMedChem (2018): https://doi.org/10.1002/cmdc.201800387.
    10.1002/cmdc.201800387
  21. Raimundo, Liliana; Espadinha, Margarida; Soares, Joana; Loureiro, Joana B.; Alves, Marco G.; Santos, Maria M. M.; Saraiva, Lucilia. "Improving anticancer activity towards colon cancer cells with a new p53-activating agent". British Journal of Pharmacology 175 20 (2018): 3947-3962. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000445328600006&KeyUID=WOS:000445328600006.
    10.1111/bph.14468
  22. Espadinha, Margarida; Barcherini, Valentina; Lopes, Elizabeth A.; Santos, Maria M. M.. "An Update on MDMX and Dual MDM2/X Inhibitors". Current Topics in Medicinal Chemistry 18 8 (2018): 647-660. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000441070600002&KeyUID=WOS:000441070600002.
    10.2174/1568026618666180604080119
  23. Soares, J.; Espadinha, M.; Raimundo, L.; Ramos, H.; Gomes, A.S.; Gomes, S.; Loureiro, J.B.; et al. "DIMP53-1: A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties". Molecular Oncology 11 6 (2017): 612-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025616812&partnerID=MN8TOARS.
    10.1002/1878-0261.12051
  24. Ribeiro, C.J.A.; Nunes, R.C.; Amaral, J.D.; Gonçalves, L.M.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030537870&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.09.037
  25. Nunes, R.C.; Ribeiro, C.J.A.; Monteiro, Â.; Rodrigues, C.M.P.; Amaral, J.D.; Santos, M.M.M.. "In vitro targeting of colon cancer cells using spiropyrazoline oxindoles". European Journal of Medicinal Chemistry 139 (2017): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026814888&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.07.057
  26. Espadinha, M.; Dourado, J.; Lajarin-Cuesta, R.; Herrera-Arozamena, C.; Gonçalves, L.M.D.; Rodríguez-Franco, M.I.; de los Rios, C.; Santos, M.M.M.. "Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists". ChemMedChem 12 7 (2017): 537-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016224641&partnerID=MN8TOARS.
    10.1002/cmdc.201700037
  27. Soares, J.; Raimundo, L.; Pereira, N.A.L.; Monteiro, Â; Gomes, S.; Bessa, C.; Pereira, C.; et al. "Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule". Oncotarget 7 4 (2016): 4326-4343. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957991161&partnerID=MN8TOARS.
    10.18632/oncotarget.6775
  28. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961801651&partnerID=MN8TOARS.
    10.1039/c5md00450k
  29. Pereira, N.A.L.; Sureda, F.X.; Pérez, M.; Amat, M.; Santos, M.M.M.. "Enantiopure indolo[2,3-a]quinolizidines: Synthesis and evaluation as NMDA receptor antagonists". Molecules 21 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84983247282&partnerID=MN8TOARS.
    10.3390/molecules21081027
  30. Ribeiro, C.J.A.; Espadinha, M.; Machado, M.; Gut, J.; Gonçalves, L.M.; Rosenthal, P.J.; Prudêncio, M.; Moreira, R.; Santos, M.M.M.. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic and Medicinal Chemistry 24 8 (2016): 1786-1792. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960971045&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.03.005
  31. Ribeiro, C.J.A.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Chemical variations on the p53 reactivation theme". Pharmaceuticals 9 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973316044&partnerID=MN8TOARS.
    10.3390/ph9020025
  32. Pereira, N.A.L.; Monteiro, Â.; Machado, M.; Gut, J.; Molins, E.; Perry, M.J.; Dourado, J.; et al. "Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites". ChemMedChem 10 12 (2015): 2080-2089. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951573479&partnerID=MN8TOARS.
    10.1002/cmdc.201500429
  33. Soares, J.; Pereira, N.A.L.; Monteiro, Â.; Leão, M.; Bessa, C.; Dos Santos, D.J.V.A.; Raimundo, L.; et al. "Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction". European Journal of Pharmaceutical Sciences 66 (2015): 138-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908509142&partnerID=MN8TOARS.
    10.1016/j.ejps.2014.10.006
  34. Pérez, M.; Espadinha, M.; Santos, M.M.M.. "Indolo[2,3-a]quinolizidines and derivatives: Bioactivity and asymmetric synthesis". Current Pharmaceutical Design 21 38 (2015): 5518-5546. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957072901&partnerID=MN8TOARS.
    10.2174/1381612821666151002112934
  35. Soares, J.; Raimundo, L.; Pereira, N.A.L.; Dos Santos, D.J.V.A.; Pérez, M.; Queiroz, G.; Leão, M.; Santos, M.M.M.; Saraiva, L.. "A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins". Pharmacological Research 95-96 (2015): 42-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961290684&partnerID=MN8TOARS.
    10.1016/j.phrs.2015.03.006
  36. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents". Bioorganic and Medicinal Chemistry 22 1 (2014): 577-584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891490447&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.10.048
  37. Pereira, N.A.L.; Sureda, F.X.; Esplugas, R.; Pérez, M.; Amat, M.; Santos, M.M.M.. "Tryptophanol-derived oxazolopiperidone lactams: Identification of a hit compound as NMDA receptor antagonist". Bioorganic and Medicinal Chemistry Letters 24 15 (2014): 3333-3336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904036543&partnerID=MN8TOARS.
    10.1016/j.bmcl.2014.05.105
  38. Monteiro, Â.; Gonçalves, L.M.; Santos, M.M.M.. "Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines". European Journal of Medicinal Chemistry 79 (2014): 266-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898838853&partnerID=MN8TOARS.
    10.1016/j.ejmech.2014.04.023
  39. Santos, M.M.M.. "Recent advances in the synthesis of biologically active spirooxindoles". Tetrahedron 70 52 (2014): 9735-9757. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913545663&partnerID=MN8TOARS.
    10.1016/j.tet.2014.08.005
  40. Santos, DM; Santos, Maria M M; Moreira, Rui; Solá, Susana; Rodrigues, CMP; Santos, D.M.; Santos, M.M.M.; et al. "Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural Stem Cell Differentiation by Regulating Redox State". Sem título 47 1 (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872501397&partnerID=MN8TOARS.
    Published • 10.1007/s12035-012-8353-y
  41. Pereira, Nuno AL; Sureda, Francesc X; Turch, M; Amat, Mercedes; Bosch, Joan; Santos, Maria MM; Pereira, N.A.L.; et al. "Synthesis of phenylalaninol-derived oxazolopyrrolidone lactams and evaluation as NMDA receptor antagonists". Sem título 144 1 (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879688023&partnerID=MN8TOARS.
    Published • 10.1007/s00706-012-0880-8
  42. Reis, Mariana; Ferreira, Ricardo J; Santos, Maria MM; Molnár, J; dos Santos, Daniel JVA; Ferreira, MJU. "Jolkinol D Derivatives as MDR Reversers: Biological Activity, Structure-Activity and Docking Studies". Sem título 1 (2013): 1-10.
    Published
  43. Ribeiro, Carlos JA; Kumar, SP; Gut, Jiri; Gonçalves, Lidia M; Rosenthal, Philip J; Moreira, Rui; Santos, Maria MM; et al. "Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents". Sem título 69 1 (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884620898&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2013.08.037
  44. Reis, M.; Ferreira, R.J.; Santos, M.M.M.; Dos Santos, D.J.V.A.; Molnár, J.; Ferreira, M.-J.U.. "Enhancing macrocyclic diterpenes as multidrug-resistance reversers: Structure-activity studies on jolkinol D derivatives". Journal of Medicinal Chemistry 56 3 (2013): 748-760. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873898843&partnerID=MN8TOARS.
    10.1021/jm301441w
  45. Amat, M.; Ramos, C.; Pérez, M.; Molins, E.; Florindo, P.; Santos, M.M.M.; Bosch, J.; et al. "Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline". Chemical Communications 49 19 (2013): 1954-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873666887&partnerID=MN8TOARS.
    Published • 10.1039/c2cc38540f
  46. Kumar, S Praveen; Glória, Paulo MC; Gonçalves, Lídia M; Gut, Jiri; Rosenthal, Philip J; Moreira, Rui; Santos, Maria MM; et al. "Squaric acid: a valuable scaffold for developing antimalarials?". Sem título 3 1 (2012): 489-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859408800&partnerID=MN8TOARS.
    Published • 10.1039/c2md20011b
  47. Ribeiro, C.J.A.; Praveen Kumar, S.; Moreira, R.; Santos, M.M.M.; Ribeiro, Carlos J. A.; Kumar, S. Praveen; Moreira, Rui; Santos, Maria M. M.. "Efficient synthesis of spiroisoxazoline oxindoles". Tetrahedron Letters 53 3 (2012): 281-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-83555174553&partnerID=MN8TOARS.
    Published • 10.1016/j.tetlet.2011.10.139
  48. Kumar, S. Praveen; Gut, Jiri; Guedes, Rita C. ; Rosenthal, Philip J.; Santos, Maria M. M.; Moreira, Rui; Praveen Kumar, S.; et al. "Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials". European Journal of Medicinal Chemistry 46 46 (2011): 927-933. http://dx.doi.org/10.1016/j.ejmech.2011.01.008.
    Published • 10.1016/j.ejmech.2011.01.008
  49. Glória, Paulo M. C. ; Coutinho, Isabel; Gonçalves, Lídia M.; Baptista, Cristina; Soares, Joana; Newton, Ana S. ; Moreira, Rui; Saraiva, Lucília; Santos, Maria M. M.. "Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway". European Journal of Medicinal Chemistry 46 (2011): 2141-2146.
    Published • 10.1016/j.ejmech.2011.02.067
  50. Pérez, Maria; Arioli, Federica; Rigacci, Gianna; Santos, Maria M. M.; Gómez-Esqué, Arantxa; Escolano, Carmen; Florindo, Pedro; et al. "Stereocontrolled Generation of Benzo[a]- and Indolo[2,3-a]quinolizidines from". Sem t�tulo 1 (2011): 3858-3863. http://dx.doi.org/10.1002/ejoc.201100294.
    Published
  51. Glória, P.M.C.; Gut, J.; Gonalves, L.M.; Rosenthal, P.J.; Moreira, R.; Santos, M.M.M.; Glória, Paulo M. C. ; et al. "Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents". Bioorganic and Medicinal Chemistry 19 24 (2011): 7635-7642. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255183034&partnerID=MN8TOARS.
    Published • 10.1016/j.bmc.2011.10.018
  52. Pérez, M.; Arioli, F.; Rigacci, G.; Santos, M.M.M.; Gõmez-Esqué, A.; Escolano, C.; Florindo, P.; et al. "Stereocontrolled generation of benzo[a]- and indolo[2,3-a]quinolizidines from (S)-tryptophanol and (S)-(3,4-dimethoxyphenyl)alaninol-derived lactams". European Journal of Organic Chemistry 20-21 (2011): 3858-3863. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960295012&partnerID=MN8TOARS.
    10.1002/ejoc.201100294
  53. Santos, Maria M. M.; Faria, Natália; Iley, Jim; Coles, Simon J.; Hursthouse, Michael B.; Martins, M. Luz; Moreira, Rui. "Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho[2,3- d]isoxazole-4,9-diones". Bioorganic and Medicinal Chemistry Letters 20 (2010): 193-195.
    Published • 10.1016/j.bmcl.2009.10.137
  54. Newton, Ana S. ; Glória, Paulo M. C. ; Gonçalves, Lídia M.; Santos, Daniel J. V. A. dos ; Moreira, Rui; Guedes, Rita C. ; Santos, Maria M. M.. "Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study". European Journal of Medicinal Chemistry 45 (2010): 3858-3863.
    Published • 10.1016/j.ejmech.2010.05.039
  55. Castro, Rui E.; Santos, Maria M. M.; Glória, Paulo M. C. ; Ribeiro, Carlos J. A.; Ferreira, Duarte M. S.; Xavier, Joana M.; Moreira, Rui; et al. "Cell Death Targets and Potential Modulators in Alzheimer’s Disease". Current Pharmaceutical Design 16 16 (2010): 2851-2864. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957958533&partnerID=MN8TOARS.
    Published
  56. Amat, Mercedes; Gomés-Esqué, Arantxa; Escolano, Carmen; Santos, Maria M. M.; Molins, Elies; Bosch, Joan; Amat, M.; et al. "Enantioselective Formal Synthesis of ( )-Dihydrocorynantheine and (-)-Dihydrocorynantheol". Journal of Organic Chemistry 74 74 (2009): 1205-1211. http://www.scopus.com/inward/record.url?eid=2-s2.0-64549158972&partnerID=MN8TOARS.
    Published • 10.1021/jo802387c
  57. Santos, D.M.; Santos, M.M.M.; Viana, R.J.S.; Castro, R.E.; Moreira, R.; Rodrigues, C.M.P.; Santos, Daniela M.; et al. "Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents". Chemico-Biological Interactions 180 2 (2009): 175-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349174541&partnerID=MN8TOARS.
    Published • 10.1016/j.cbi.2009.03.007
  58. Santos, Maria M. M.; Newton, Ana S.; Coutinho, Isabel; Gloria, Paulo M. C.; Saraiva, Lucilia; Moreira, Rui. "VINYL SULFONES AS CASPASE INHIBITORS". Drugs of the Future 34 (2009): 176-176.
  59. Amat, Mercedes; Santos, Maria M. M.; Bassas, Oriol; Llor, Núria; Escolano, Carmen; Gomés-Esqué, Arantxa; Molins, Elies; et al. "Straightforward Methodology for the Enantioselective Synthesis of Benzo[a]- and Indolo[2,3-a]quinolizidines". Journal of Organic Chemistry 72 14 (2007): 5193-5201. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447317528&partnerID=MN8TOARS.
    Published • 10.1021/jo070539g
  60. Amat, M.; Santos, M.M.M.; Gómez, A.M.; Jokic, D.; Molins, E.; Bosch, J.. "Enantioselective spirocyclizations trom tryptophanol-derived oxazolopiperidone lactams". Organic Letters 9 15 (2007): 2907-2910. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547148914&partnerID=MN8TOARS.
    10.1021/ol0712327
  61. Santos, M.M.M.; Moreira, R.; Santos, Maria M. M.; Moreira, Rui. "Michael acceptors as cysteine protease inhibitors". Mini-Reviews in Medicinal Chemistry 7 10 (2007): 1040-1050. http://www.scopus.com/inward/record.url?eid=2-s2.0-35048878659&partnerID=MN8TOARS.
    Published • 10.2174/138955707782110105
  62. Allin, S.M.; Duffy, L.J.; Bulman Page, P.C.; McKee, V.; Edgar, M.; McKenzie, M.J.; Amat, M.; et al. "Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets". Tetrahedron Letters 47 32 (2006): 5713-5716. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745879813&partnerID=MN8TOARS.
    Published • 10.1016/j.tetlet.2006.06.035
  63. Amat, Mercedes; Bassas, Oriol; Cantó, Margalida; Llor, Núria; Santos, Maria M. M.; Bosch, Joan. "A convenient synthetic route to 3-acetonyl- and 3-(2-oxoethyl)glutarates". Tetrahedron 61 (2005): 7693-7702.
    Published
  64. Amat, M.; Bassas, O.; Cantó, M.; Llor, N.; Santos, M.M.M.; Bosch, J.. "Synthesis of 3-acetonyl- and 3-(2-oxoethyl)glutarates". Tetrahedron 61 32 (2005): 7693-7702. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844454223&partnerID=MN8TOARS.
    10.1016/j.tet.2005.05.084
  65. Bassas, O.; Llor, N.; Santos, M.M.M.; Griera, R.; Molins, E.; Amat, M.; Bosch, J.. "Biogenetically inspired enantioselective approach to indolo[2,3-a]- and benzo[a]quinolizidine alkaloids from a synthetic equivalent of secologanin". Organic Letters 7 14 (2005): 2817-2820. http://www.scopus.com/inward/record.url?eid=2-s2.0-22244448384&partnerID=MN8TOARS.
    10.1021/ol0505609
  66. Santos, Maria M. M.; Lobo, Ana M.; Prabhakar, Sundaresan; Marques, M. Manuel B.; Santos, M.M.M.; Lobo, A.M.; Prabhakar, S.; Marques, M.M.B.. "A new approach to N-protected staurosporinones". Tetrahedron Letters 45 45 (2004): 2347-2349. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242270584&partnerID=MN8TOARS.
    Published • 10.1016/j.tetlet.2004.01.089
  67. Gaudêncio, S.P.; Santos, M.M.M.; Lobo, A.M.; Prabhakar, S.; Gaudêncio, Susana P.; Santos, Maria M. M.; Lobo, Ana M.; Prabhakar, Sundaresan. "A short synthesis of staurosporinone (K-252c)". Tetrahedron Letters 44 12 (2003): 2577-2578. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037450946&partnerID=MN8TOARS.
    Published • 10.1016/S0040-4039(03)00279-X
  68. Janosik, T.; Bergman, J.; Romero, I.; Stensland, B.; Stålhandske, C.; Marques, M.M.B.; Santos, M.M.M.; et al. "Synthetic, spectroscopic, and X-ray crystallographic studies of [1,2,7,8]tetrathiacyclododecino[4,3-b:5,6-b:10,9-b:11,12-b]tetraindoles". European Journal of Organic Chemistry 8 (2002): 1392-1396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036224172&partnerID=MN8TOARS.
    10.1002/1099-0690(200204)2002:8<1392::AID-EJOC1392>3.0.CO;2-#
  69. Marques, M. Manuel B.; Santos, Maria M. M.; Lobo, Ana M.; Prabhakar, Sundaresan ; Marques, M.M.B.; Santos, M.M.M.; Lobo, A.M.; Prabhakar, S.. "A novel synthesis of arcyriaflavin-A via an intramolecular sulfur extrusion reaction". Tetrahedron Letters 41 41 (2000): 9835-9838. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034627357&partnerID=MN8TOARS.
    Published • 10.1016/S0040-4039(00)01782-2

Intellectual property

Patent
  1. Lourenço, Nuno T.; Sobral, Luis; Antunes, Rafael; Santos, Maria M. M.; Espadinha, Margarida. 2018. "Process for the preparation of Umeclidinium bromide (WO/2018/087561 A1 20180517)".
    Granted/Issued
  2. Saraiva, Lucília; Santos, Maria M. M.; Pereira, Nuno A. L.; Pereira, Clara; Moreira, Sara; Leão, Mariana; Monteiro, Ângelo; Soares, Joana. 2016. "Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators (WO2014207688A1, US9732091B2, EP3013833B1, PT3013833T)".
    Granted/Issued
Distinctions

Other distinction

2024 Foreign faculty member of the Ph.D. Programme in Research Methods in Science and Technology of the University of Urbino
Università degli Studi di Urbino Carlo Bo, Italy
2018 Member of the International Advisory Board of ChemMedChem (Wiley-VCH)
2016 Nominated as Portuguese NAO Liason officer
2016 Mulheres na Ciência (WOMAN IN SCIENCE)
2015 Nominated a New Talent:Europe by MedChemComm
Royal Society of Canada, Canada
2015 Portuguese Award for Best Young Organic Chemist 2015
2015 elected member of the EXECUTIVE COMMITTEE of the medicinal chemistry division