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Maria Emilia Carreira Saraiva Monteiro is a Medical Doctor (Universidad de Navarra, Spain) and full professor of Pharmacology at Nova Medical School, Universidade Nova de Lisboa. Has a PhD in Biomedical Sciences (1994) by Universidade do Porto (Portugal) and a PhD in Physiology by Universidad de Navarra. She is senior investigator at CEDOC-iNOVA4Health, coordinates the thematic line ¿Cardio Metabolic disorders¿ and is member of the executive committee of INOVA4Health research unit (graded with Excellent by the Portuguese funding agency). Her main scientific interests are pharmacology of cardiovascular diseases related with oxygen disturbances; drug-related adverse effects and research infrastructures for clinical research . Supervised 11 PhD thesis already finished, published 88 scientific articles that generated 1423 Citations and has 3 on going research grants supported by competitive funds (1 ERASMUS+). Presently, coordinates PtCRIN ¿ Portuguese Clinical Research Infrastructure network, integrated in the national and European roadmap of research infrastructures; is member (evaluation of clinical trials) of the National Ethics Committee for Clinical Research (CEIC); is senior clinical and scientific lead of the academic clinical trial unit NOVACRU; is member of the Collaborative-CoLab Trials (a public-private association supported by european infrastructure funds to foster innovation); is member of the scientific council of the ANSM ¿Agence Nationale de Sécurité du Medicament et des Produits de Santé¿ (France) and full member and Treasure of the Portuguese Academy of Medicine representing the academy in FEAM. Was vice-dean for education of Nova Medical School from 2010-2017 and Delegate of Portugal in the FP 7 and Horizon 2020- topic, SC1 "Health, demographic change and wellbeing". Has been involved in the evaluation of research infrastructures in the Czech Republic; member of the ¿Comité Científico Asesor Externo de SCReN¿, (Spanish Clinical Research network); co-director of the Portugal Clinical Scholars Research Training (PTCSRT) from Harvard Medical School (2012-2022); President of the International Society for Arterial Chemoreception (ISAC) and of the Portuguese Society of Pharmacology. She is the chair of curricular units in under graduate (Pharmacology in medicine) and graduate programes (Core methodologies in biomedical and clinical research - PhD program in Health Sciences, NOVA Medical School) and involved in several graduate programes in the area of clinical research and pharmaceutical medicine.
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Identification

Personal identification

Full name
Maria Emilia Carreira Saraiva Monteiro

Citation names

  • Monteiro, EC

Author identifiers

Ciência ID
5918-54A6-FAA0
ORCID iD
0000-0002-0570-0765

Addresses

  • Campo Mártires da Pátria, 130, 1150-090, Lisbon, Lisbon, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Clinical Medicine
  • Medical and Health Sciences - Clinical Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2008
Concluded
 Habilitation (Outros)
Universidade Nova de Lisboa, Portugal
1994
Concluded
 PhD in Medicine (Doutoramento)
Major in Pharmacology
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Efeitos Respiratórios e Cardiovasculares da Adenosina in Vivo" (THESIS/DISSERTATION)
1984
Concluded
 PhD in Medicine (Doutoramento)
Major in Physiology
Universidad de Navarra Facultad de Medicina, Spain
1982
Concluded
 Medicine (Licenciatura)
Universidad de Navarra Facultad de Medicina, Spain
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2012 - Current Full Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Positions / Appointments

Category
Host institution 		Employer
2021 - Current Council Member, Portuguese Academy of Medicine representative Federation of European Academies of Medicine, FEAM, Belgium
Federation of European Academies of Medicine, FEAM, Belgium
2021 - Current Coordinator of the PhD grant panel, Clinical Medicine and Health Sciences Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2020 - Current Coordinator of the National Roadmap Infrastructure PtCRIN, Portuguese Clinical Research Infrastructure Network, Portugal
PtCRIN, Portuguese Clinical Research Infrastructure Network, Portugal
(...)
2019 - Current Chair of the Curricular Unit Core Methodologies in Biomedical and Clinical Research, PhD Program in Health Sciences Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Chair of the Curricular Unit Pathophysiology and Therapeutic Targets, Integrated Master in Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - Current Coordinator of the Thematic Line "Cardio Metabolic Disorders" of the Portuguese Research Unit iNOVA4health Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
iNOVA4Health, Portugal
2018 - Current iNOVA4Health Management Board Universidade Nova de Lisboa, Portugal
iNOVA4Health, Portugal
2014 - Current Member of the Network Committee European Clinical Research Infrastructure Network, France
European Clinical Research Infrastructure Network, France
2013 - Current Senior Clinical and Scientific lead of the academic clinical trial unit NOVACRU Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - Current Member of the Scientific Council Agence nationale de sécurité du médicament et des produits de santé, France
Agence nationale de sécurité du médicament et des produits de santé, France
2012 - Current Coordinator of the Portuguese Cinical Research Infraestructures Network (PtCRIN), the national partner of the ECRIN/ERIC Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - Current Member CEIC, Comissão de Ética para a Investigação Clínica, Portugal
CEIC, Comissão de Ética para a Investigação Clínica, Portugal
2008 - Current Principal Investigator of the research group of Translational Pharmacology Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
(...)
2015 - 2022 Co-Director, Portugal Clinical Scholars Research Training (PTCSRT) Harvard Medical School, United States
Harvard Medical School, United States
2017 - 2020 Chair of the Curricular Unit Medical Devices, Integrated Master in Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2003 - 2018 Chair of the Curricular Units Pharmacology and/or General Pharmacology, Integrated Master of Medicine Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2017 Organic Unit Sub-director Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Others

Category
Host institution 		Employer
2020 - Current CEDOC (Chronic Diseases Center)_Member of the executive board Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Projects

Grant

Designation Funders
2021/11/01 - 2024/10/31 Conscious II, Curriculum development of Human Clinical Trials
2021-1-CZ01-KA220-HED-000023177
Researcher
Universidade Nova de Lisboa, Portugal
 European Commission
Ongoing
2020 - 2022 Relevance of the Ratio Kynurenine/Tryptophan to Characterize Hypertension Associated to Obstructive Sleep Apnea (KYNTOSA)
PTDC/MED-TOX30418/2017
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Ongoing
2019 - 2021 CONSCIOUS, Curriculum Development of Human Clinical Trials for the Next Generation Biomedical Students
2018-1-HU01-KA203-047811
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 European Commission
Concluded

Contract

Designation Funders
2020 - Current Muscle up with intermittent hypoxia: a matter of intensity, gender and metabolism
iNOVA4Health- IUDB/004462/2020/TL2/P2
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

iNOVA4Health, Portugal
iNOVA4Health

Fundação para a Ciência e a Tecnologia
Ongoing
2018 - Current AhR-CYP1A: linking environmental exposure and sleep apnea to improve arterial hypertension management
PTDC/MED-TOX/30418/2017
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - Current Efficacy of olive oil and phenolic compounds in reversing hypertension induced by chronic intermittent hypoxia
FCT20160102021
iNOVA4Health – MULTI/04462
iNOVA4Health MULTI/04462
Researcher
iNOVA4Health, Portugal
 Fundação para a Ciência e a Tecnologia

iNOVA4Health
Ongoing
2014 - 2024 Portuguese Clinical Research Infrastructures network (PtCRIN)
2013/713/EU
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 Variability of 1A1 sulfotransferase activity in humans: an approach to predict drug response - 2nd part: Analysis of inter-individual variability in hypertensive patients.
EudraCT 2019-002266-12 and CEIC 20191098
Supervisor
Hospital da Luz Lisboa, Portugal
Ongoing
2016 - 2019 Variability of sulfotransferase 1A1 activity in humans: an approach to improve predictive drug response? Part I: Analysis of intraindividual variation in healthy adults
Protocol nº HLUZ_001_2016; EudraCT nº: 2016-001395-29
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Hospital da Luz Lisboa
Concluded
2011 - 2014 Hepatic toxicity in HIVinfected individuals exposed to nevirapine
PTDC/SAUORG/ 111663/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
2011 - 2014 Chronic Intermitent Eucapnic Hypoxia: systemic effects and evaluation of antihypertensive drugs efficacy
PTDC/SAUTOX/112264/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Gonçalves-Dias, Clara; Sequeira, Catarina O.; Vicente, João B.; Correia, M. João; Coelho, Nuno R.; Morello, Judit; Antunes, Alexandra M. M.; et al. "A Mechanistic-Based and Non-invasive Approach to Quantify the Capability of Kidney to Detoxify Cysteine-Disulfides". In Advances in Experimental Medicine and Biology, 109-120. Springer International Publishing, 2021.
    Published • 10.1007/978-3-030-63908-2_8
  2. Isabel Faro de Albuquerque; Catarina Martins Lopes; Nuno Lourenço-Silva; José Fragata; Monteiro, EC. "Which medical professional?". In From Life Molecules to Global Health, 620-632. PRINCIPIA, 2021.
    Published
  3. João Filipe Raposo; José A. Belo; Sílvia V. Conde; Monteiro, EC; José Silva Nunes; Pereira, Sofia A.; Gabriela A. Silva; Maria Paula Macedo. "B FROM A CLASSICAL TO A NEW NOVA PERSPECTIVE ON CARDIOMETABOLIC DISEASES". In From Life Molecules to Global Health, 261-290. PRINCIPIA, 2021.
    Published
  4. Coelho, Nuno R.; Dias, Clara G.; João Correia, M.; Grácio, Patrícia; Serpa, Jacinta; Monteiro, Emília C.; Diogo, Lucília N.; Pereira, Sofia A.. "Cysteine Oxidative Dynamics Underlies Hypertension and Kidney Dysfunction Induced by Chronic Intermittent Hypoxia". In Advances in Experimental Medicine and Biology, 83-88. Springer International Publishing, 2018.
    10.1007/978-3-319-91137-3_10
  5. Monteiro, EC. "Understanding the molecular basis for the hazards associated with Nevirapine treatment". In Advances in Medicine and Biology, 77-100. Nova Science Publishers, 2012.
  6. CONDE, SÍLVIA V.; MONTEIRO, EMÍLIA C.. "Profiles for ATP and Adenosine Release at the Carotid Body in Response to O2 Concentrations". In ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 179-184. Springer US, 2006.
    10.1007/0-387-31311-7_27
  7. Monteiro, EC. "Perfil Farmacológico dos fármacos agonistas dos receptores B2. Em: Agonistas dos receptores B2". In Curso Interactivo de Pneumologia, 719. Permanyer Portugal, 2002.
  8. Monteiro, EC. "Endogenous adenosine tonically excites respiration mediated through carotid body chemoreceptors in the rat". In Arterial Chemoreception, 174-180. Springer Verlag, New York, 1990.
  9. Monteiro, EC. "Respiratory responses to common carotid occlusion in the rat: evidence for involvement of adenosine". In Chemoreceptors and Chemoreceptor reflexes, 49-56. Plenum Press, New York, 1990.
  10. Monteiro, EC. "The actions of adenosine on respiration". In Physiology and Pharmacology of Adenosine and Adenine nucleotides, 225-232. Taylor and Francis, Ltd, London, 1988.
  11. Monteiro, EC. "Adenosine modulation of respiration mediated by carotid body chemoreceptors". In Chemoreceptors and Respiratory Control, 314-320. Croom Helm, London, 1987.
  12. Monteiro, EC. "Fisiologia de la Tos". In Libro de Homenaje al Prof. Ortiz de Landazuri. Garsi, Madrid, 1984.
Conference abstract
  1. Monteiro, EC. "Metabolomics of drug-induced renal injury in zebrafishlarvae [oral presentation]". Paper presented in XLVII meeting of thePortugueseSociety of Pharmacology, 2018.
  2. Monteiro, EC. "Is zebrafish a good model to assess drug-inducedrenalinjury? [inivited oral presentation]". Paper presented in 3rd International Conference on Urine Omics and 2nd International CaparicaConference inTranslational Nephrology, 2017.
  3. Monteiro, EC. "Molecular targeting of proteins by homocysteine inhypercholesterolemia [oral presentation]". Paper presented in XLVI ReuniãoAnual da Sociedade Portuguesa de Farmacologia/ XXXIII Reunião deFarmacologia Clínica/ XV Reunião de Toxicologia, 2016.
  4. Monteiro, EC. "Modulation of paraoxonase-1 by nevirapine: comparisonbetween three in vitro models [oral presentation]". Paper presented in XLVIReunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIII Reunião deFarmacologia Clínica/ XV Reunião de Toxicologia, 2016.
  5. Monteiro, EC. "Urinary N-acetylated cysteine-disulfides as indicators ofkidney disease progression in HIV-infected patients [oral presentation]". Paper presented in 7th European Congress of Pharmacology (EPHAR), 2016.
  6. Monteiro, EC. "Monitoring glomerular function in zebrafish larvae (Daniorerio) exposed to nephrotoxic drugs. [oral presentation]". Paper presented in XLV meeting of the Portuguese Society of Pharmacology, 2015.
  7. Monteiro, EC. "The role of Nevirapine phase I metabolites in the renalfunction of HIV-infected patients [oral presentation]". Paper presented in 1stInternational Caparica Conference in Translational Nephrology & 18thPortuguese Symposium on Renal Diseases, 2014.
  8. Monteiro, EC. "Antivíricos diretos e imunossupressores: interações [invitedoral presentation]". Paper presented in Workshop Hepatite C - InovaçãoFarmacologia e Transplantação, 2014.
  9. Monteiro, EC. "Relevance of CYP2C19 genotypes in Nevirapinebiotransformation [oral presentation]". Paper presented in European Society ofPharmacogenomics and Theranostics (ESPT) Second Conference.Pharmacogenomics: from Cell to Clinic, 2013.
  10. Monteiro, EC. "Effect of chronic exposure to the antiretroviral drugnevirapine on paraoxonase-1 activities in HIV-infected patients [oralpresentation]". Paper presented in 2nd International Conference onOccupational & Environmental Toxicology, 2013.
  11. Monteiro, EC. "Biomedical models for translational research [invited oralpresentation]". Paper presented in 3º Congresso Internacional de Enfermagem Veterinária, 2013.
  12. Monteiro, EC. "Hemoglobin adducts from the antiretroviralabacavir in HIV-infected patients as evidence of bioactivation [oralpresentation]". Paper presented in 244th ACS National Meeting & Exposition, Philadelphia, 2012.
Conference paper
  1. Gracio, Patricia C.; Goncalves-Dias, Clara; Lopes-Coelho, Filipa; Monteiro, Emilia C.; Serpa, Jacinta; da Silva, Claudia L.; Pereira, Sofia A.. "Changes in N-acetyltransferase 8 in kidney tubular cell: injury, recovery and mesenchymal stromal cell-based therapy". 2019.
    10.1109/enbeng.2019.8692517
  2. Diogo, Lucilia N.; Pereira, Sofia A.; Nunes, Ana R.; Afonso, Ricardo A.; Santos, Ana I.; Monteiro, Emilia C.. "Hypertension induced by chronic intermittent hypoxia: Effects of carvedilol in a rat model". 2015.
    10.1183/13993003.congress-2015.oa294
Conference poster
  1. Monteiro, EC; Coelho, Nuno; Tomkiewcz, Céline; Correia, M João; Pimpão, António; Barouki, Robert; Coumoul, Xavier; Pereira, Sofia A.. "P19-ARYL HYDROCARBON RECEPTOR ANTAGONISTS - A NEW ENTRY IN ANTIHYPERTENSIVE ARMAMENTARIUM OF OBSTRUCTIVE SLEEP APNEA?". Paper presented in ESH-ISH Joint Meeting - Hypertension meeting participation, 2021.
Journal article
  1. Correia, Maria João; Pimpão, António B.; Fernandes, Dalila G. F.; Morello, Judit; Sequeira, Catarina O.; Calado, Joaquim; Antunes, Alexandra M. M.; et al. "Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine". Molecules 27 4 (2022): 1416. http://dx.doi.org/10.3390/molecules27041416.
    Published • 10.3390/molecules27041416
  2. Coelho, N. R.; Pimpão, A. B.; Correia, M. J.; Rodrigues, T. C.; Monteiro, E. C.; Morello, J.; Pereira, S. A.. "Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence". Journal of Molecular Medicine 100 2 (2021): 215-243. http://dx.doi.org/10.1007/s00109-021-02163-2.
    Published • 10.1007/s00109-021-02163-2
  3. Pinheiro Andrade, Maria; Matias, Daniela; Batuca, Joana; Gouveia, Nélia; Mota-Filipe, Hélder; Carreira Monteiro, Emília; Madeira, Catarina. "Portuguese Authorship in Published Clinical Trials: Differences in Industry and Investigator Initiated Trials". Acta Médica Portuguesa 34 11 (2021): 733. http://dx.doi.org/10.20344/amp.14554.
    Published • 10.20344/amp.14554
  4. Correia, Maria João; Pimpão, António B.; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Coelho, Nuno R.; Gonçalves-Dias, Clara; Barouki, Robert; et al. "Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex". Antioxidants 10 9 (2021): 1484. http://dx.doi.org/10.3390/antiox10091484.
    Published • 10.3390/antiox10091484
  5. Martins, Fátima O.; Sacramento, Joana F.; Olea, Elena; Melo, Bernardete F.; Prieto-Lloret, Jesus; Obeso, Ana; Rocher, Asuncion; et al. "Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation". Antioxidants 10 8 (2021): 1233. http://dx.doi.org/10.3390/antiox10081233.
    Published • 10.3390/antiox10081233
  6. Marto, Natalia; Morello, Judit; Antunes, Alexandra; Monteiro, Emília; Pereira, Sofia. "Phenotyping SULT in Man: a Simple Metric Using Paracetamol as Probe". The FASEB Journal 35 S1 (2021): http://dx.doi.org/10.1096/fasebj.2021.35.s1.03064.
    Published • 10.1096/fasebj.2021.35.s1.03064
  7. Marto, Natália; Morello, Judit; Antunes, Alexandra M. M.; Azeredo, Sofia; Monteiro, Emília C.; Pereira, Sofia A.. "A simple method to measure sulfonation in man using paracetamol as probe drug". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-88393-3.
    10.1038/s41598-021-88393-3
  8. Marinho, Aline T.; Batuca, Joana R.; Miranda, Joana P.; Caixas, Umbelina; Dias, Clara G.; Branco, Teresa; Soto, Karina; et al. "The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies". Pharmacological Research (2021): 105446. http://dx.doi.org/10.1016/j.phrs.2021.105446.
    10.1016/j.phrs.2021.105446
  9. Coelho, Nuno R.; Matos, Clara; Pimpão, António B.; Correia, M. João; Sequeira, Catarina O.; Morello, Judit; Pereira, Sofia A.; Monteiro, Emília C.. "AHR canonical pathway: in vivo findings to support novel antihypertensive strategies". Pharmacological Research (2021): 105407. http://dx.doi.org/10.1016/j.phrs.2020.105407.
    10.1016/j.phrs.2020.105407
  10. Brinkman DJ; Monteiro T; Monteiro EC; Richir MC; van Agtmael MA; Tichelaar J. "Switching from a traditional undergraduate programme in (clinical) pharmacology and therapeutics to a problem-based learning programme.". European journal of clinical pharmacology (2020): http://europepmc.org/abstract/med/33098019.
    10.1007/s00228-020-03027-3
  11. Helena Pite; Laura Aguiar; Judit Morello; Emilia Monteiro; Ana Catarina Alves; Mafalda Bourbon; Mário Morais-Almeida. "

    Metabolic Dysfunction and Asthma: Current Perspectives

    ". Journal of Asthma and Allergy (2020): https://doi.org/10.2147/JAA.S208823.
    10.2147/JAA.S208823
  12. Marto N; Monteiro EC. "Medicines for the Treatment Of COVID-19: Awaiting the Evidence.". Acta medica portuguesa (2020): http://europepmc.org/abstract/med/32425152.
    10.20344/amp.13908
  13. Coelho NR; Tomkiewicz C; Correia MJ; Gonçalves-Dias C; Barouki R; Pereira SA; Coumoul X; Monteiro EC. "First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia.". Pharmacological research (2020): http://europepmc.org/abstract/med/32416216.
    10.1016/j.phrs.2020.104869
  14. Magnin, Annette; Iversen, Valentina Cabral; Calvo, Gonzalo; Cecetková, Beata; Dale, Ola; Demlová, Regina; Blaskó, György; et al. "European survey on national harmonization in clinical research". Learning Health Systems 5 2 (2020): http://dx.doi.org/10.1002/lrh2.10220.
    Published • 10.1002/lrh2.10220
  15. Magnin, A.; Iversen, V. Cabral; Calvo, G.; Cecetková, B.; Dale, O.; Demlova, R.; Blasko, Gy.; et al. "European survey on national training activities in clinical research". Trials 20 1 (2019): http://dx.doi.org/10.1186/s13063-019-3702-z.
    10.1186/s13063-019-3702-z
  16. Joana F. Sacramento; Elena Olea; Maria J. Ribeiro; Jesus Prieto-Lloret; Bernardete F. Melo; Constancio Gonzalez; Fatima O. Martins; Emilia C. Monteiro; Silvia V. Conde. "Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing". The Journal of Physiology (2019): https://doi.org/10.1113/JP274179.
    10.1113/JP274179
  17. Monteiro, Maria. "Appropriate antibiotic prescribing among final-year medical students in Europe". International Journal of Antimicrobial Agents (2019): http://dx.doi.org/10.1016/j.ijantimicag.2019.05.008.
    10.1016/j.ijantimicag.2019.05.008
  18. Monteiro, Maria. "Transparency and accuracy in funding investigator-initiated clinical trials: a systematic search in clinical trials databases". BMJ Open (2019): http://dx.doi.org/10.1136/bmjopen-2018-023394.
    10.1136/bmjopen-2018-023394
  19. Gonçalves-Dias; Morello; Semedo; Correia; Coelho; Monteiro; Antunes; Pereira. "The mercapturomic profile of health and non-communicable diseases". High-Throughput 8 2 (2019): 10-10. https://doi.org/10.3390/ht8020010.
    10.3390/ht8020010
  20. Monteiro, Maria. "Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease". Nephron (2019): http://dx.doi.org/10.1159/000494390.
    10.1159/000494390
  21. Aline T. Marinho; Joana P. Miranda; Umbelina Caixas; Catarina Charneira; Clara Gonçalves-Dias; M. Matilde Marques; Emília C. Monteiro; Alexandra M. M. Antunes; Sofia A. Pereira. "Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity". Drug Metabolism Reviews 51 1 (2019): 76-90. https://doi.org/10.1080/03602532.2019.1577891.
    10.1080/03602532.2019.1577891
  22. Morello, Judit; Derks, Rico J. E.; Lopes, Susana S.; Steenvoorden, Evelyne; Monteiro, Emilia C.; Mayboroda, Oleg A.; Pereira, Sofia A.. "Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.01193.
    10.3389/fphar.2018.01193
  23. Brinkman DJ; Tichelaar J; Mokkink LB; Christiaens T; Likic R; Maciulaitis R; Costa J; et al. "Key learning outcomes for clinical pharmacology and therapeutics education in Europe: A modified Delphi study.". Clinical pharmacology and therapeutics (2017): http://europepmc.org/abstract/med/29205299.
    10.1002/cpt.962
  24. Gorgulho R; Jacinto R; Lopes SS; Pereira SA; Tranfield EM; Martins GG; Gualda EJ; et al. "Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations.". Archives of toxicology (2017): http://europepmc.org/abstract/med/28932931.
    10.1007/s00204-017-2063-1
  25. Marto N; Morello J; Monteiro EC; Pereira SA. "Implications of sulfotransferase activity in interindividual variability in drug response: clinical perspective on current knowledge.". Drug metabolism reviews (2017): http://europepmc.org/abstract/med/28554218.
    10.1080/03602532.2017.1335749
  26. Grilo NM; João Correia M; Miranda JP; Cipriano M; Serpa J; Matilde Marques M; Monteiro EC; et al. "Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2017): http://europepmc.org/abstract/med/28487145.
    10.1016/j.ejps.2017.05.010
  27. Brinkman DJ; Tichelaar J; Schutte T; Benemei S; Böttiger Y; Chamontin B; Christiaens T; et al. "Essential competencies in prescribing: A first european cross-sectional study among 895 final-year medical students.". Clinical pharmacology and therapeutics (2017): http://europepmc.org/abstract/med/27648725.
    10.1002/cpt.521
  28. Conde SV; Monteiro EC; Sacramento JF. "Purines and Carotid Body: New Roles in Pathological Conditions.". Frontiers in pharmacology (2017): http://europepmc.org/abstract/med/29311923.
    10.3389/fphar.2017.00913
  29. Grilo NM; Correia MJ; Sequeira C; Harjivan SG; Caixas U; Diogo LN; Marques MM; et al. "Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients.". Toxicology letters (2016): http://europepmc.org/abstract/med/27543169.
    10.1016/j.toxlet.2016.08.009
  30. Pedroso D; Nunes AR; Diogo LN; Oudot C; Monteiro EC; Brenner C; Vieira HLA. "Hippocampal neurogenesis response: What can we expect from two different models of hypertension?". Brain research (2016): http://europepmc.org/abstract/med/27235865.
    10.1016/j.brainres.2016.05.044
  31. Vera-Cruz P; Rito M; Diogo L; Zagalo C; Dos Santos JM; Monteiro ME. "Structure of the rat tracheal mucosa after chronic intermittent hypoxia or chronic hyperbaric oxygen therapy.". (2016): http://europepmc.org/abstract/med/26648111.
    10.14670/HH-11-703
  32. Sacramento JF; Ribeiro MJ; Rodrigues T; Guarino MP; Diogo LN; Seiça R; Monteiro EC; Matafome P; Conde SV. "Insulin resistance is associated with tissue-specific regulation of HIF-1a and HIF-2a during mild chronic intermittent hypoxia.". (2016): http://europepmc.org/abstract/med/26993367.
    10.1016/j.resp.2016.03.007
  33. Alvarez-Martins I; Remédio L; Matias I; Diogo LN; Monteiro EC; Dias S; Alvarez-Martins, I.; et al. "The impact of chronic intermittent hypoxia on hematopoiesis and the bone marrow microenvironment.". Pflugers Archiv European Journal of Physiology 468 5 (2016): 919-932. http://europepmc.org/abstract/med/26856724.
    10.1007/s00424-016-1797-6
  34. Marinho AT; Dias CG; Pinheiro PF; Lemos AR; Antunes AM; Marques MM; Monteiro EC; Miranda JP; Pereira SA. "Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach.". (2016): http://europepmc.org/abstract/med/26620700.
    10.1016/j.ejps.2015.11.019
  35. Madeira, C.; Pais, A.; Kubiak, C.; Demotes, J.; Monteiro, E.C.. "Investigator-initiated clinical trials conducted by the Portuguese Clinical Research Infrastructure Network (PtCRIN)". Contemporary Clinical Trials Communications 4 (2016): 141-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84986253551&partnerID=MN8TOARS.
    10.1016/j.conctc.2016.08.002
  36. Diogo LN; Pereira SA; Nunes AR; Afonso RA; Santos AI; Monteiro EC. "Efficacy of carvedilol in reversing hypertension induced by chronic intermittent hypoxia in rats.". (2015): http://europepmc.org/abstract/med/26291659.
    10.1016/j.ejphar.2015.08.019
  37. Diogo LN; Faustino IV; Afonso RA; Pereira SA; Monteiro EC; Santos AI. "Voluntary Oral Administration of Losartan in Rats.". (2015): http://europepmc.org/abstract/med/26424254.
  38. Diogo LN; Pinto P; Bárbara C; Monteiro EC; Papoila AL. "Neck circumference and body mass index as independent predictors of hypertension misclassification in patients suspected of having obstructive sleep apnea.". (2015): http://europepmc.org/abstract/med/25121756.
    10.1097/MBP.0000000000000080
  39. Diogo, L.N.; Faustino, I.V.; Afonso, R.A.; Pereira, S.A.; Monteiro, E.C.; Santos, A.I.. "Voluntary oral administration of losartan in rats". Journal of the American Association for Laboratory Animal Science 54 5 (2015): 549-556. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943195739&partnerID=MN8TOARS.
  40. Diogo LN; Pinto P; Bárbara C; Papoila AL; Monteiro EC. "The Association Between Antihypertensive Medication and Blood Pressure Control in Patients with Obstructive Sleep Apnea.". (2015): http://europepmc.org/abstract/med/26303482.
    10.1007/978-3-319-18440-1_22
  41. Nunes AR; Monteiro E; Gauda E. "Soluble adenylyl cyclase in the locus coeruleus.". (2014): http://europepmc.org/abstract/med/24973474.
    10.1016/j.resp.2014.05.011
  42. Grilo NM; Charneira C; Pereira SA; Monteiro EC; Marques MM; Antunes AM. "Bioactivation to an aldehyde metabolite--possible role in the onset of toxicity induced by the anti-HIV drug abacavir.". (2014): http://europepmc.org/abstract/med/24211422.
    10.1016/j.toxlet.2013.10.036
  43. Dias C; Marinho A; Morello J; Almeida G; Caixas U; Soto K; Monteiro E; Pereira S. "Monitoring of the lactonase activity of paraoxonase-1 enzyme in HIV-1-infection.". (2014): http://europepmc.org/abstract/PMC/PMC4225321.
    10.7448/IAS.17.4.19682
  44. Marinho A; Dias C; Antunes A; Caixas U; Branco T; Marques M; Monteiro E; Pereira S. "Sex differences in apolipoprotein A1 and nevirapine-induced toxicity.". (2014): http://europepmc.org/abstract/med/25394082.
    10.7448/IAS.17.4.19575
  45. Nunes AR; Holmes AP; Conde SV; Gauda EB; Monteiro EC. "Revisiting cAMP signaling in the carotid body.". (2014): http://europepmc.org/abstract/med/25389406.
    10.3389/fphys.2014.00406
  46. Diogo LN; Monteiro EC. "The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions.". (2014): http://europepmc.org/abstract/med/25295010.
    10.3389/fphys.2014.00361
  47. Conde SV; Sacramento JF; Guarino MP; Gonzalez C; Obeso A; Diogo LN; Monteiro EC; Ribeiro MJ. "Carotid body, insulin, and metabolic diseases: unraveling the links.". (2014): http://europepmc.org/abstract/med/25400585.
    10.3389/fphys.2014.00418
  48. Dias, C.G.; Batuca, J.R.; Marinho, A.T.; Caixas, U.; Monteiro, E.C.; Antunes, A.M.M.; Pereira, S.A.. "Quantification of the arylesterase activity of paraoxonase-1 in human blood". Analytical Methods 6 1 (2014): 289-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890071175&partnerID=MN8TOARS.
    10.1039/c3ay41527a
  49. Marinho, A.T.; Godinho, A.L.A.; Novais, D.A.; Antunes, A.M.M.; Marques, M.M.; Ramos, T.; Dias, C.G.; Monteiro, E.C.; Pereira, S.A.. "Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase i metabolites in human blood". Analytical Methods 6 5 (2014): 1575-1580. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894120111&partnerID=MN8TOARS.
    10.1039/c3ay41911h
  50. Marinho, A. T.; Rodrigues, P. M.; Caixas, U.; Antunes, A. M. M.; Branco, T.; Harjivan, S. G.; Marques, M. M.; Monteiro, E. C.; Pereira, S. A.. "Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions". Journal of Antimicrobial Chemotherapy 69 2 (2013): 476-482. http://dx.doi.org/10.1093/jac/dkt359.
    10.1093/jac/dkt359
  51. Ribeiro MJ; Sacramento JF; Gonzalez C; Guarino MP; Monteiro EC; Conde SV. "Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets.". (2013): http://europepmc.org/abstract/med/23530003.
    10.2337/db12-1463
  52. Grilo, N.M.; Antunes, A.M.M.; Caixas, U.; Marinho, A.T.; Charneira, C.; Conceição Oliveira, M.; Monteiro, E.C.; Matilde Marques, M.; Pereira, S.A.. "Monitoring abacavir bioactivation in humans: Screening for an aldehyde metabolite". Toxicology Letters 219 1 (2013): 59-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875885900&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.02.021
  53. Nunes, A.R.; Holmes, A.P.S.; Sample, V.; Kumar, P.; Cann, M.J.; Monteiro, E.C.; Zhang, J.; Gauda, E.B.. "Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors". Respiratory Physiology and Neurobiology 188 2 (2013): 83-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880100523&partnerID=MN8TOARS.
    10.1016/j.resp.2013.05.013
  54. Charneira, C.; Grilo, N.M.; Pereira, S.A.; Godinho, A.L.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.. "N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo". British Journal of Pharmacology 167 6 (2012): 1353-1361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867773600&partnerID=MN8TOARS.
    10.1111/j.1476-5381.2012.02079.x
  55. Nunes AR; Sample V; Xiang YK; Monteiro EC; Gauda E; Zhang J; Nunes, A.R.; et al. "Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia.". Advances in Experimental Medicine and Biology 758 (2012): 287-294. http://europepmc.org/abstract/med/23080174.
    10.1007/978-94-007-4584-1_39
  56. Conde SV; Obeso A; Monteiro EC; Gonzalez C; Conde, S.V.; Obeso, A.; Monteiro, E.C.; Gonzalez, C.. "Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats.". Advances in Experimental Medicine and Biology 758 (2012): 315-323. http://europepmc.org/abstract/med/23080178.
    10.1007/978-94-007-4584-1_43
  57. Caixas, U.; Antunes, A.M.M.; Marinho, A.T.; Godinho, A.L.A.; Grilo, N.M.; Marques, M.M.; Oliveira, M.C.; et al. "Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity". Toxicology 301 1-3 (2012): 33-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864807069&partnerID=MN8TOARS.
    10.1016/j.tox.2012.06.013
  58. Conde, S.V.; Ribeiro, M.J.; Obeso, A.; Rigual, R.; Monteiro, E.C.; Gonzalez, C.. "Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output". Molecular Pharmacology 82 6 (2012): 1056-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869858797&partnerID=MN8TOARS.
    10.1124/mol.112.081216
  59. Conde, S.V.; Nunes Da Silva, T.; Gonzalez, C.; Mota Carmo, M.; Monteiro, E.C.; Guarino, M.P.. "Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats". British Journal of Nutrition 107 1 (2012): 86-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855787744&partnerID=MN8TOARS.
    10.1017/S0007114511002406
  60. Conde, S.V.; Monteiro, E.C.; Rigual, R.; Obeso, A.; Gonzalez, C.. "Hypoxic intensity: A determinant for the contribution of ATP and adenosine to the genesis of carotid body chemosensory activity". Journal of Applied Physiology 112 12 (2012): 2002-2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862579463&partnerID=MN8TOARS.
    10.1152/japplphysiol.01617.2011
  61. Pereira, S.A.; Wanke, R.; Marques, M.M.; Monteiro, E.C.; Antunes, A.M.M.. "Insights into the role of bioactivation mechanisms in the toxic events elicited by non-nucleoside reverse transcriptase inhibitors". Advances in Molecular Toxicology 6 (2012): 1-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865355478&partnerID=MN8TOARS.
    10.1016/B978-0-444-59389-4.00001-X
  62. Caixas, U.; Ferreira, J.; Marinho, A.T.; Faustino, I.; Grilo, N.M.; Lampreia, F.; Germano, I.; Monteiro, E.C.; Pereira, S.A.. "Long-term maraviroc use as salvage therapy in HIV-2 infection". Journal of Antimicrobial Chemotherapy 67 10 (2012): 2538-2539. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866613168&partnerID=MN8TOARS.
    10.1093/jac/dks240
  63. Monteiro, T.C.; Batuca, J.R.; Obeso, A.; González, C.; Monteiro, E.C.. "Carotid body function in aged rats: Responses to hypoxia, ischemia, dopamine, and adenosine". Age 33 3 (2011): 337-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-80655145960&partnerID=MN8TOARS.
    10.1007/s11357-010-9187-z
  64. Charneira, C.; Godinho, A.L.A.; Oliveira, M.C.; Pereira, S.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.. "Reactive aldehyde metabolites from the anti-HIV drug abacavir: Amino acid adducts as possible factors in abacavir toxicity". Chemical Research in Toxicology 24 12 (2011): 2129-2141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84055218870&partnerID=MN8TOARS.
    10.1021/tx200337b
  65. Nunes, A.R.; Batuca, J.R.; Monteiro, E.C.. "Acute hypoxia modifies cAMP levels induced by inhibitors of phosphodiesterase-4 in rat carotid bodies, carotid arteries and superior cervical ganglia". British Journal of Pharmacology 159 2 (2010): 353-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-75649134184&partnerID=MN8TOARS.
    10.1111/j.1476-5381.2009.00534.x
  66. Pereira, S. A.; Batuca, J. R.; Caixas, U.; Branco, T.; Delgado-Alves, J.; Germano, I.; Lampreia, F.; Monteiro, E. C.. "Effect of efavirenz on high-density lipoprotein antioxidant properties in HIV-infected patients". British Journal of Clinical Pharmacology 68 6 (2009): 891-897. http://dx.doi.org/10.1111/j.1365-2125.2009.03535.x.
    10.1111/j.1365-2125.2009.03535.x
  67. Conde, S.V.; Obeso, A.; Monteiro, E.C.; Gonzalez, C.. "The A 2B-D 2 receptor interaction that controls carotid body catecholamines release locates between the last two steps of hypoxic transduction cascade". Advances in Experimental Medicine and Biology 648 (2009): 161-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651205673&partnerID=MN8TOARS.
    10.1007/978-90-481-2259-2_18
  68. Conde, S.V.; Monteiro, E.C.; Obeso, A.; Gonzalez, C.. "Adenosine in peripheral chemoreception: New insights into a historically overlooked molecule". Advances in Experimental Medicine and Biology 648 (2009): 145-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651205671&partnerID=MN8TOARS.
    10.1007/978-90-481-2259-2_17
  69. Nunes, A.R.; Batuca, J.R.; Monteiro, E.C.. "Functional characterization of phosphodiesterases 4 in the rat carotid body: Effect of oxygen concentrations". Advances in Experimental Medicine and Biology 648 (2009): 113-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651219181&partnerID=MN8TOARS.
    10.1007/978-90-481-2259-2_13
  70. Nunes, A.R.; Monteiro, E.C.; Johnson, S.M.; Gauda, E.B.. "Bicarbonate-regulated soluble adenylyl cyclase (sAC) mRNA expression and activity in peripheral chemoreceptors". Advances in Experimental Medicine and Biology 648 (2009): 235-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651207741&partnerID=MN8TOARS.
    10.1007/978-90-481-2259-2_27
  71. Monteiro, T.C.; Obeso, A.; Gonzalez, C.; Monteiro, E.C.. "Does ageing modify ventilatory responses to dopamine in anaesthetised rats breathing spontaneously?". Advances in Experimental Medicine and Biology 648 (2009): 265-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651205663&partnerID=MN8TOARS.
    10.1007/978-90-481-2259-2_30
  72. Pereira, S.A.; Branco, T.; Caixas, U.; Côrte-Real, R.M.; Germano, I.; Lampreia, F.; Monteiro, E.C.. "Intra-individual variability in efavirenz plasma concentrations supports therapeutic drug monitoring based on quarterly sampling in the first year of therapy". Therapeutic Drug Monitoring 30 1 (2008): 60-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549087038&partnerID=MN8TOARS.
    10.1097/FTD.0b013e318160ce76
  73. Pereira, S.A.; Caixas, U.; Branco, T.; Germano, I.; Lampreia, F.; Papoila, A.L.; Monteiro, E.C.. "Efavirenz concentrations in HIV-infected patients with and without viral hepatitis". British Journal of Clinical Pharmacology 66 4 (2008): 551-555. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649096977&partnerID=MN8TOARS.
    10.1111/j.1365-2125.2008.03238.x
  74. Conde, S.V.; Gonzalez, C.; Batuca, J.R.; Monteiro, E.C.; Obeso, A.. "An antagonistic interaction between A2B adenosine and D 2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells". Journal of Neurochemistry 107 5 (2008): 1369-1381. http://www.scopus.com/inward/record.url?eid=2-s2.0-55849129304&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05704.x
  75. Conde, S.V.; Monteiro, E.C.. "Activation of nicotinic ACh receptors with a4 subunits induces adenosine release at the rat carotid body". British Journal of Pharmacology 147 7 (2006): 783-789. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645547406&partnerID=MN8TOARS.
    10.1038/sj.bjp.0706676
  76. Pereira, S.A.; Branco, T.; Côrte-Real, R.M.; Germano, I.; Lampreia, F.; Caixas, U.; Monteiro, E.C.. "Long-term and concentration-dependent beneficial effect of efavirenz on HDL-cholesterol in HIV-infected patients". British Journal of Clinical Pharmacology 61 5 (2006): 601-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646265773&partnerID=MN8TOARS.
    10.1111/j.1365-2125.2006.02619.x
  77. Conde, S.V.; Obeso, A.; Rigual, R.; Monteiro, E.C.; Gonzalez, C.. "Function of the rat carotid body chemoreceptors in ageing". Journal of Neurochemistry 99 3 (2006): 711-723. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750080433&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04094.x
  78. Conde SV; Monteiro EC. "Profiles for ATP and adenosine release at the carotid body in response to O2 concentrations.". (2006): http://europepmc.org/abstract/med/16683716.
  79. Conde, S.V.; Monteiro, E.C.. "Profiles for ATP and adenosine release at the carotid body in response to O2 concentrations.". Advances in experimental medicine and biology. 580 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33745233081&partnerID=MN8TOARS.
  80. Conde, S.V.; Monteiro, E.C.. "Profiles for ATP and adenosine release at the carotid body in response to O2 concentrations". Advances in Experimental Medicine and Biology 580 (2006): 179-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745233081&partnerID=MN8TOARS.
    10.1007/0-387-31311-7-27
  81. Conde, S.V.; Monteiro, E.C.. "Hypoxia induces adenosine release from the rat carotid body". Journal of Neurochemistry 89 5 (2004): 1148-1156. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642526852&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.02380.x
  82. Batuca JR; Monteiro TC; Monteiro EC. "Contribution of dopamine D2 receptors for the cAMP levels at the carotid body.". (2003): http://europepmc.org/abstract/med/14635690.
  83. Conde SV; Monteiro EC. "Adenosine-acetylcholine interactions at the rat carotid body.". (2003): http://europepmc.org/abstract/med/14635682.
  84. Conde, S.V.; Monteiro, E.C.. "Adenosine-Acetylcholine Interactions at the Rat Carotid Body". Advances in Experimental Medicine and Biology 536 (2002): 305-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344688361&partnerID=MN8TOARS.
  85. Batuca, J.R.; Monteiro, T.C.; Monteiro, E.C.. "Contribution of Dopamine D2 Receptors for the cAMP Levels at the Carotid Body". Advances in Experimental Medicine and Biology 536 (2002): 367-373. http://www.scopus.com/inward/record.url?eid=2-s2.0-3543138433&partnerID=MN8TOARS.
  86. Monteiro EC; Ribeiro JA. "Adenosine-dopamine interactions and ventilation mediated through carotid body chemoreceptors.". (2000): http://europepmc.org/abstract/med/10849708.
  87. Monteiro, E.C.; Ribeiro, J.A.. "Adenosine-dopamine interactions and ventilation mediated through carotid body chemoreceptors". Advances in Experimental Medicine and Biology 475 (2000): 671-684. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034465679&partnerID=MN8TOARS.
  88. Monteiro EC; Vera-Cruz P; Monteiro TC; Silva e Sousa MA. "Adenosine increases the cAMP content of the rat carotid body in vitro.". (1996): http://europepmc.org/abstract/med/9030315.
  89. Monteiro, E.C.; Vera-Cruz, P.; Monteiro, T.C.; Silva E Sousa, M.A.. "Adenosine increases the cAMP content of the rat carotid body in vitro". Advances in Experimental Medicine and Biology 410 (1996): 299-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030452543&partnerID=MN8TOARS.
  90. Monteiro EC; Ribeiro JA; Monteiro, E.C.; Ribeiro, J.A.. "Adenosine and the bradycardiac response to vagus nerve stimulation in rats.". European Journal of Pharmacology 204 2 (1991): 193-202. http://europepmc.org/abstract/med/1806387.
    10.1016/0014-2999(91)90705-U
  91. Monteiro, E.C.; Ribeiro, J.A.. "Involvement of adenosine during stimulation of ventilation induced by common carotid occlusion". Revista Portuguesa de Hemorreologia 5 2 (1991): 249-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025950467&partnerID=MN8TOARS.
  92. Ribeiro, J.A.; Monteiro, E.C.. "On the adenosine receptor involved in the excitatory action of adenosine on respiration: Antagonist profile". Nucleosides and Nucleotides 10 5 (1991): 945-953. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026005936&partnerID=MN8TOARS.
    10.1080/07328319108047232
  93. Monteiro EC; Ribeiro JA; Monteiro, E.C.; Ribeiro, J.A.. "Adenosine deaminase and adenosine uptake inhibitions facilitate ventilation in rats.". Naunyn-Schmiedeberg's Archives of Pharmacology 340 2 (1989): 230-238. http://europepmc.org/abstract/med/2812035.
    10.1007/BF00168974
  94. Monteiro, E.C.; Ribeiro, J.A.; Monteiro EC; Ribeiro JA. "Inhibition by 1,3-dipropyl-8(p-sulfophenyl)xanthine of the respiratory stimulation induced by common carotid occlusion in rats". Life Sciences 45 10 (1989): 939-945. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024453848&partnerID=MN8TOARS.
    10.1016/0024-3205(89)90208-7
  95. Monteiro, E.C.; Ribeiro, J.A.; Monteiro EC; Ribeiro JA. "Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat". Naunyn-Schmiedeberg's Archives of Pharmacology 335 2 (1987): 143-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023102955&partnerID=MN8TOARS.
    10.1007/BF00177715
Online resource
  1. Monteiro, EC. Layman summary: Zebrafish is an attractive model to anticipate drug-induced renal injury in humans. 2018. http://atlasofscience.org/zebrafish-is-an-attractive-model-to-anticipate-drug-induced-renal-injury-in-humans/.
Report
  1. 2022. Immunisation for old adults in Europe: scientific and social strategies. https://www.feam.eu/feam-publications/.

Intellectual property

Patent
  1. Monteiro, EC. 2019. "2-hydroxy-nevirapine analogues or derivatives for use in the treatment of diseases related to high density lipoprotein dysfunction. PPI 2019/20066".

Other

Other output
  1. Investigator initiated clinical trials (IICTs): a systematic search in registries comparing Czech Republic and Portugal in terms of funding policies and scientific outcomes. 2020. Catarina Madeira; Lenka Horavová; Francisco dos Santos; Joana Batuca; Katerina Nebeska; Lenka Souckova; Christine Kubiak; et al. https://doi.org/10.21203/rs.2.24789/v1.
    10.21203/rs.2.24789/v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/04/29 Phenotyping SULT in Man: a Simple Metric Using Paracetamol as Probe (R3064 poster) ASPET Annual Meeting at EB 2021

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2016 - 2020 ARYL HYDROCARBON RECEPTOR (AHR): A THERAPEUTIC TARGET FOR SYSTEMIC HYPERTENSION ASSOCIATED WITH CHRONIC INTERMITTENT HYPOXIA
Supervisor
 Doutor em Mecanismos de Doença e Medicina Regenerativa (PhD)
Universidade Nova de Lisboa, Portugal
2014 - 2019 The multimorbidity of asthma and rhinitis: from epidemiologic data to molecular traits
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2018 Teaching an old drug new tricks: reprofiling of nevirapine as an HDL modulator
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2015 Evaluation of antihypertensive drugs in patients with obstructive sleep apnea and in rat s submitted to chronic intermittent hypoxia
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2014 New insights for understanding postoperative cognitive dysfunction
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - 2013 O2/CO2sensitive cAMP signaling pathway in peripher al chemoreceptors
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2005 - 2011 Functional evaluation of carotid body in ageing
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2006 - 2010 Therapeutic drug monitoring of efavirenz in clinical practice and long term effects of the drug
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2003 - 2007 Functional significance of adenosine receptors in carotid body chemosensory activity in control and chronically hypoxic animals
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/06/27 - 2022/06/30 Organization of the Meeting of the International Society for Arterial Chemoreception (2022/06/27 - 2022/06/30)
Meeting
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2015 Organization of the Meeting of the Portguese Society of Pharmacology 2015 (2015 - 2015)
Meeting
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/11/09 - Current Roundtable ´´Training of Clinical Research Centers in Portugal``: How to promote quality, efficiency and cooperation?
Round table
 Prémios AICIB 2021
2010 - Current Pariticipation in the OPEN DAYS of the institute (outreach activities).
Other
 OPEN DAYS CEDOC | FCM
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/01/31 - 2022/01/31 How should Europe prepare and respond to cross-border health threats: HERA?
Workshop
 How should Europe prepare and respond to cross-border health threats: HERA?
Federation of European Academies of Medicine, FEAM, Belgium
2021/02/18 - 2021/02/18 Chair at CLINICAL PHARMACOLOGY II session
Meeting
 SPF Meeting 2021
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Farmacologia, Portugal
2021/02/17 - 2021/02/17 ROUNDTABLE member: Teaching Pharmacology, Therapeutics and Toxicology
Meeting
 SPF Meeting 2021
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Farmacologia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/20 "Targeting the carotid bodies to treat obesity"
President of the jury
 Bernardete Sofia Freitas de Melo (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Association member

Society Organization name Role
2021 - Current CoLAB trials, Nova Medical School Representative
2019 - Current Full member of the Portuguese Academy of Medicine
2017 - 2020 President of the International Society for Arterial Chemoreception (ISAC) Presdent
2016 - 2018 Correspondent member of the Portuguese Academy of Medicine Correspondent Member
2009 - 2017 Society of Medical Sciences of Lisbon Member of the Direction
2009 - 2013 President of the Portuguese Society of Pharmacology and Clinical Pharmacology President

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Council Member, Portuguese Academy of Medicine representative
Member
 Federation of European Academies of Medicine, FEAM, Belgium
2020 - Current Member of the executive board of CEDOC (CENTRO DE ESTUDOS DE DOENÇAS CRÓNICAS)
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - Current External advisor of the Scientific Committee of the Spanish Clinical Research Network ISCIII
Advisor / Consultant
 Instituto de Salud Carlos III, Spain
2014 - Current Member of the Network Committee
Member
 European Clinical Research Infrastructure Network, France
2013 - Current Member of the scientific council of the “Agence Nationale de Sécurité du Medicament et des Produits de Santé”
Member
 Agence nationale de sécurité du médicament et des produits de santé, France
2013 - Current Member of the Scientific Council
Member
 Agence nationale de sécurité du médicament et des produits de santé, France
2013 - Current Senior Clinical and Scientific lead of the academic clinical trial unit NOVACRU
Other
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - Current Member of the National Ethics Committee for Clinical Research (CEIC). Evaluator of Clinical trials
Member
 Comissão de Ética para a Investigação Clínica, Portugal
2009 - Current Member
Member
 CEIC, Comissão de Ética para a Investigação Clínica, Portugal
2017 - 2020 Vice-chair of the ECRIN-ERIC steering committee (European Clinical Research Infrastructure Network/ European Research Infrastructures Consortium)
2013 - 2018 Member of the pedagogic council of the Nova Medical School Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2017 Preparation of the Portuguese Strategic Agenda for Research and Innovation in Health.
Member
2013 - 2014 Delegate of Portugal in the FP 7 and Horizon 2020- topic, SC1 "Health, demographic change and wellbeing"
2010 - 2011 Collaborator in the preparation of Portuguese National Health Programme 2011-2016 in the area of drugs, technologies and medical devices

Consulting

Activity description Institution / Organization
2018 - Current iNOVA4Health Management Board Universidade Nova de Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Curricular Unit Core Methodologies in Research. Ciências da Saúde (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Chair of the Curricular Unit Core Methodologies in Biomedical and Clinical Research, PhD Program in Health Sciences (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Current Chair of the Curricular Unit Pathophysiology and Therapeutic Targets, Integrated Master in Medicine (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Current Nuclear Curricular Unit of Phatophysiology and Therapeutic Targets Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2022 Module 6 - Exploratory Development (Molecule for Proof of Concept) (Pós-Graduação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2022 Module 4 - Non-Clinical Tests (Pós-Graduação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2020 Chair of the Curricular Unit Medical Devices, Integrated Master in Medicine Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - 2018 Chair of the Curricular Units Pharmacology and/or General Pharmacology, Integrated Master of Medicine Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2003 - 2018 Curricular units Pharmacology and/or General Pharmacology Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018 - 2018 Member of the evaluation panel of the research grants supported by the "Agence Nationale de Sécurité du Medicament et des Produits de Santé"
Member
 Agence nationale de sécurité du médicament et des produits de santé, France
2010 - 2017 Evaluator of research grants and scientific projects at Foundation for Science and Technology, Portuguese Ministry of Education and Science
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal