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Identification

Personal identification

Full name
Nuno Milhazes

Citation names

  • Milhazes, Nuno

Author identifiers

Ciência ID
5919-8A5A-0F00
ORCID iD
0000-0002-5171-0454
Education
Degree Classification
2007
Concluded
 Química Farmacêutica (Doutoramento)
Major in Não Aplicável
Universidade do Porto Faculdade de Farmácia, Portugal
1998
Concluded
 Ciências Farmacêuticas (Licenciatura)
Major in Não Aplicável
Universidade do Porto Faculdade de Farmácia, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2013 - Current Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2013 - 2018 Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Saude do Norte Escola Superior de Saúde do Vale do Sousa, Portugal
2014 - 2015 Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Saude do Norte Escola Superior de Saúde do Vale do Ave, Portugal

Positions / Appointments

Category
Host institution 		Employer
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Instituto Universitário de Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Serafim, T.L.; Milhazes, N.; Borges, F.; Oliveira, P.J.. Caffeic and Ferulic Acid Derivatives: Use in Breast Cancer. 2014.
    10.1016/B978-0-12-409517-5.00074-7
  2. Borges, M.F.M.; Roleira, F.M.F.; Milhazes, N.J.S.P.; Villares, E.U.; Penin, L.S.. Simple coumarins: Privileged scaffolds in medicinal chemistry. 2009.
  3. Simões, P.F.; Silva, A.P.; Pereira, F.C.; Marques, E.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Macedo, T.R.. Methamphetamine canges NMDA and AMPA glutamate receptor subunit levels in the rat striatum and frontal cortex. 2008.
    10.1196/annals.1432.028
  4. Gonçalves, J.; Martins, T.; Ferreira, R.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Malva, J.O.; Macedo, T.R.; Silva, A.P.. Methamphetamine-induced early increase of IL-6 and TNF-a mRNA expression in the mouse brain. 2008.
    10.1196/annals.1432.043
  5. Pereira, F.C.; Lourenço, E.; Milhazes, N.; Morgadinho, T.; Ribeiro, C.F.; Ali, S.F.; Macedo, T.R.. Methamphetamine, morphine, and their combination: Acute changes in striatal dopaminergic transmission evaluated by microdialysis in awake rats. 2006.
    10.1196/annals.1369.016
Journal article
  1. Reis, J.; Gaspar, A.; Milhazes, N.; Borges, F.. "Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances". Journal of Medicinal Chemistry 60 19 (2017): 7941-7957. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031293351&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b01720
  2. Garrido, E.M.; Rodrigues, D.; Milhazes, N.; Borges, F.; Garrido, J.. "Molecular encapsulation of herbicide terbuthylazine in native and modified ß-cyclodextrin". Journal of Chemistry 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018819102&partnerID=MN8TOARS.
    10.1155/2017/8120367
  3. Baptista, S.; Lourenço, J.; Milhazes, N.; Borges, F.; Silva, A.P.; Bacci, A.. "Long-term treatment with low doses of methamphetamine promotes neuronal differentiation and strengthens long-term potentiation of glutamatergic synapses onto dentate granule neurons". eNeuro 3 3 (2016): 2413-2423. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010237500&partnerID=MN8TOARS.
    10.1523/ENEURO.0141-16.2016
  4. Gaspar, A.; Milhazes, N.; Santana, L.; Uriarte, E.; Borges, F.; Matos, M.J.. "Oxidative stress and neurodegenerative diseases: Looking for a therapeutic solution inspired on benzopyran chemistry". Current Topics in Medicinal Chemistry 15 5 (2015): 432-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930908241&partnerID=MN8TOARS.
  5. Baptista, Sofia; Lasgi, Charlène; Benstaali, Caroline; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Agasse, Fabienne; et al. "Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate". Stem Cell Research 13 2 (2014): 329-341. http://hdl.handle.net/10316/27821.
    10.1016/j.scr.2014.08.003
  6. Almeida, Hugo Leite; Melo, António; Pêgo, José M.; Bernardo, Sara; Milhazes, Nuno; Borges, Fernanda; Sousa, Nuno; et al. "Variable delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in rats". Frontiers in Behavioral Neuroscience OCT (2013): http://hdl.handle.net/1822/26949.
    10.3389/fnbeh.2013.00154
  7. Borges, F.; Reis, J.; Encarnação, I.; Gaspar, A.; Morales, A.; Milhazes, N.. "Parkinson's disease management. part iidiscovery of mao-b inhibitors based on nitrogen heterocycles and analogues". Current Topics in Medicinal Chemistry 12 20 (2012): 2116-2130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874913282&partnerID=MN8TOARS.
  8. Reis, J.; Oliveira, C.; Milhazes, N.; Viña, D.; Borges, F.. "Exploring nitrostyrene as a scaffold for a new class a of monoamine oxidase inhibitors". Letters in Drug Design and Discovery 9 10 (2012): 958-961. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870431026&partnerID=MN8TOARS.
    10.2174/157018012804586888
  9. Gaspar, A.; Reis, J.; Fonseca, A.; Milhazes, N.; Viña, D.; Uriarte, E.; Borges, F.. "Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors". Bioorganic and Medicinal Chemistry Letters 21 2 (2011): 707-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651257725&partnerID=MN8TOARS.
    10.1016/j.bmcl.2010.11.128
  10. Gaspar, A.; Teixeira, F.; Uriarte, E.; Milhazes, N.; Melo, A.; Cordeiro, M.N.D.S.; Ortuso, F.; Alcaro, S.; Borges, F.. "Towards the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone Amides". ChemMedChem 6 4 (2011): 628-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066953&partnerID=MN8TOARS.
    10.1002/cmdc.201000452
  11. Martins, T.; Baptista, S.; Gonçalves, J.; Leal, E.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; et al. "Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9". Brain Research 1411 (2011): 28-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052037570&partnerID=MN8TOARS.
    10.1016/j.brainres.2011.07.013
  12. Serafim, Teresa L.; Carvalho, Filipa S.; Marques, Maria P. M.; Calheiros, Rita; Silva, Tiago; Garrido, J.M.P.J.; Milhazes, Nuno; et al. "Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against Human Breast Cancer Cells". (2011): http://hdl.handle.net/10400.22/10235.
    10.1021/tx200126r
  13. Garrido, E.M.P.J.; Garrido, J.M.P.J.; Milhazes, N.; Borges, F.; Oliveira-Brett, A.M.. "Electrochemical oxidation of amphetamine-like drugs and application to electroanalysis of ecstasy in human serum". Bioelectrochemistry 79 1 (2010): 77-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951976659&partnerID=MN8TOARS.
    10.1016/j.bioelechem.2009.12.002
  14. Stefano Alcaro; Alexandra Gaspar; Francesco Ortuso; Nuno Milhazes; Francisco Orallo; Eugenio Uriarte; Matilde Yáñez; et al. "Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B". Bioorganic and Medicinal Chemistry Letters 20 9 (2010): 2709-2712. https://repositorio-aberto.up.pt/handle/10216/96094.
    10.1016/j.bmcl.2010.03.081
  15. Fernanda M. F. Roleira; Christophe Siquet; Elizabeta Orrù; E. Manuela Garrido; Jorge Garrido; Nuno Milhazes; Gianni Podda; et al. "Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties". Bioorganic and Medicinal Chemistry 18 16 (2010): 5816-5825. https://repositorio-aberto.up.pt/handle/10216/100809.
    10.1016/j.bmc.2010.06.090
  16. goncalves, joana; baptista, sofia; martins, tania; milhazes, nuno; borges, fernanda; ribeiro, carlos f.; malva, joao o.; et al. "Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin". European Journal of Neuroscience 31 2 (2010): 315-326. https://repositorio-aberto.up.pt/handle/10216/91224.
    10.1111/j.1460-9568.2009.07059.x
  17. Reis, B.; Martins, M.; Barreto, B.; Milhazes, N.; Garrido, E.M.; Silva, P.; Garrido, J.; Borges, F.. "Structure-property-activity relationship of phenolic acids and derivatives. Protocatechuic acid alkyl esters". Journal of Agricultural and Food Chemistry 58 11 (2010): 6986-6993. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953145782&partnerID=MN8TOARS.
    10.1021/jf100569j
  18. Gaspar, A.; Garrido, E.M.; Esteves, M.; Quezada, E.; Milhazes, N.; Garrido, J.; Borges, F.. "New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives". European Journal of Medicinal Chemistry 44 5 (2009): 2092-2099. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749186901&partnerID=MN8TOARS.
    10.1016/j.ejmech.2008.10.027
  19. Calheiros, R.; Machado, N.F.L.; Fiuza, S.M.; Gaspar, A.; Garrido, J.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Antioxidant phenolic esters with potential anticancer activity: A Raman spectroscopy study". Journal of Raman Spectroscopy 39 1 (2008): 95-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549148538&partnerID=MN8TOARS.
    10.1002/jrs.1822
  20. Milhazes, N.; Martins, P.; Uriarte, E.; Garrido, J.; Calheiros, R.; Marques, M.P.M.; Borges, F.; et al. "Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors". Analytica Chimica Acta 596 2 (2007): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447260978&partnerID=MN8TOARS.
    10.1016/j.aca.2007.06.027
  21. Simões, P.F.; Silva, A.P.; Pereira, F.C.; Marques, E.; Grade, S.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Macedo, T.R.. "Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory". Neuroscience 150 2 (2007): 433-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749024725&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2007.09.044
  22. Gulaboski, R.; Cordeiro, M.N.D.S.; Milhazes, N.; Garrido, J.; Borges, F.; Jorge, M.; Pereira, C.M.; et al. "Evaluation of the lipophilic properties of opioids, amphetamine-like drugs, and metabolites through electrochemical studies at the interface between two immiscible solutions". Analytical Biochemistry 361 2 (2007): 236-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846486983&partnerID=MN8TOARS.
    10.1016/j.ab.2006.11.006
  23. Milhazes, N.; Cunha-Oliveira, T.; Martins, P.; Garrido, J.; Oliveira, C.; Rego, A.C.; Borges, F.. "Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship". Chemical Research in Toxicology 19 10 (2006): 1294-1304. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209029&partnerID=MN8TOARS.
    10.1021/tx060123i
  24. Milhazes, Nuno; Calheiros, Rita; Marques, M. Paula M.; Garrido, Jorge; Cordeiro, M. Natália D. S.; Rodrigues, Cátia; Quinteira, Sandra; et al. "ß-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study". Bioorganic and Medicinal Chemistry 14 12 (2006): 4078-4088. http://hdl.handle.net/10316/45140.
    10.1016/j.bmc.2006.02.006
  25. Borges, F.; Roleira, F.; Milhazes, N.; Santana, L.; Uriarte, E.. "Simple coumarins and analogues in medicinal chemistry: Occurrence, synthesis and biological activity". Current Medicinal Chemistry 12 8 (2005): 887-916. http://www.scopus.com/inward/record.url?eid=2-s2.0-15944389028&partnerID=MN8TOARS.
    10.2174/0929867053507315
  26. Calheiros, R.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "ß-Nitrostyrene derivatives - A conformational study by combined Raman spectroscopy and ab initio MO calculations". Journal of Molecular Structure 692 1-3 (2004): 91-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842612527&partnerID=MN8TOARS.
    10.1016/j.molstruc.2004.01.012
  27. Carvalho, M.; Remião, F.; Milhazes, N.; Borges, F.; Fernandes, E.; Do Céu Monteiro, M.; Gonçalves, M.J.; et al. "Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro". Chemical Research in Toxicology 17 5 (2004): 623-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442639021&partnerID=MN8TOARS.
    10.1021/tx049960f
  28. Carvalho, M.; Milhazes, N.; Remião, F.; Borges, F.; Fernandes, E.; Amado, F.; Monks, T.J.; Carvalho, F.; Bastos, M.L.. "Hepatotoxicity of 3,4-methylenedioxyamphetamine and a-methyldopamine in isolated rat hepatocytes: Formation of glutathione conjugates". Archives of Toxicology 78 1 (2004): 16-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-1442278713&partnerID=MN8TOARS.
    10.1007/s00204-003-0510-7
  29. Carvalho, M.; Remião, F.; Milhazes, N.; Borges, F.; Fernandes, E.; Carvalho, F.; Bastos, M.L.. "The toxicity of N-methyl-a-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine". Toxicology 200 2-3 (2004): 193-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942714874&partnerID=MN8TOARS.
    10.1016/j.tox.2004.03.016
  30. Fiuza, S.M.; Van Besien, E.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Conformational analysis of a trihydroxylated derivative of cinnamic acid - A combined Raman spectroscopy and Ab initio study". Journal of Molecular Structure 693 1-3 (2004): 103-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942422260&partnerID=MN8TOARS.
    10.1016/j.molstruc.2004.02.019
  31. Fiuza, S.M.; Gomes, C.; Teixeira, L.J.; Girão Da Cruz, M.T.; Cordeiro, M.N.D.S.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Phenolic acid derivatives with potential anticancer properties - A structure-activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acids". Bioorganic and Medicinal Chemistry 12 13 (2004): 3581-3589. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942612898&partnerID=MN8TOARS.
    10.1016/j.bmc.2004.04.026
  32. Santana, L.; Uriarte, E.; Roleira, F.; Milhazes, N.; Borges, F.. "Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity". Current Medicinal Chemistry 11 24 (2004): 3239-3261. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844219683&partnerID=MN8TOARS.
  33. Milhazes, Nuno; Borges, Fernanda; Calheiros, Rita; Marques, M. Paula M.; Milhazes, N.; Borges, F.; Calheiros, R.; Marques, M.P.M.. "Identification of synthetic precursors of amphetamine-like drugs using Raman spectroscopy and ab initio calculations: beta-Methyl-beta-nitrostyrene derivatives". Analyst 129 11 (2004): 1106-1117. http://hdl.handle.net/10316/45149.
    10.1039/b405290k
  34. Remião, F.; Milhazes, N.; Borges, F.; Carvalho, F.; Bastos, M.L.; Lemos-Amado, F.; Domingues, P.; Ferrer-Correia, A.. "Synthesis and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood". Biomedical Chromatography 17 1 (2003): 6-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037281216&partnerID=MN8TOARS.
    10.1002/bmc.203
  35. Gomes, Catarina A.; Cruz, Teresa Girão da; Andrade, José L.; Milhazes, Nuno; Borges, Fernanda; Marques, M. Paula M.; Gomes, C.A.; et al. "Anticancer Activity of Phenolic Acids of Natural or Synthetic Origin:  A Structure-Activity Study". Journal of Medicinal Chemistry 46 25 (2003): 5395-5401. http://hdl.handle.net/10316/45155.
    10.1021/jm030956v
  36. Carvalho, M.; Hawksworth, G.; Milhazes, N.; Borges, F.; Monks, T.J.; Fernandes, E.; Carvalho, F.; et al. "Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: An in vitro study using rat and human renal proximal tubular cells". Archives of Toxicology 76 10 (2002): 581-588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036390214&partnerID=MN8TOARS.
    10.1007/s00204-002-0381-3
  37. Lemos-Amado, F.; Domingues, P.; Ferrer-Correia, A.; Remião, F.; Milhazes, N.; Borges, F.; Carvalho, F.D.; Bastos, M.L.. "Electrospray tandem mass spectrometry of aminochromes". Rapid Communications in Mass Spectrometry 15 24 (2001): 2466-2471. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035543079&partnerID=MN8TOARS.
    10.1002/rcm.498
Thesis / Dissertation
  1. Milhazes, Nuno Jorge da Silva Pereira. "Obtenção e análise de metabolitos e intermediários de síntese : estudos de correlação entre estruturas, propriedades físico-químicas e actividade biológica". PhD, 2006. http://hdl.handle.net/10216/64023.