Identification
Personal identification
- Full name
- Luka Clarke
Citation names
- Clarke, Luka
- Clarke, Luka A
- Clarke, LA
Author identifiers
- Ciência ID
- 591E-5E28-94A0
- ORCID iD
- 0000-0003-3254-9121
- Google Scholar ID
- https://scholar.google.pt/citations?user=14hRaK8AAAAJ&hl=en&oi=ao
- Scopus Author Id
- 9248448600
Websites
- https://ciencias.ulisboa.pt/perfil/laclarke (Professional)
Knowledge fields
- Natural sciences - Biological Sciences - Molecular Biology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
English (Mother tongue) | |||||
Portuguese | Advanced (C1) | Proficiency (C2) | Upper intermediate (B2) | Proficiency (C2) | Upper intermediate (B2) |
French | Intermediate (B1) | Upper intermediate (B2) | Intermediate (B1) | Intermediate (B1) | |
German | Beginner (A1) | Intermediate (B1) | Beginner (A1) | Beginner (A1) | |
Spanish; Castilian | Beginner (A1) | Intermediate (B1) | Beginner (A1) | Beginner (A1) | |
Japanese | Beginner (A1) | Beginner (A1) | Beginner (A1) | Beginner (A1) |
Education
Degree | Classification | |
---|---|---|
1997
Concluded
|
PhD Molecular Endocrinology (Doctor of Philosophy)
University of London (Royal Veterinary College), United Kingdom
"Physiological function of prolactin based on hormone receptor studies in the red deer (Cervus elaphus)." (THESIS/DISSERTATION)
|
n/a |
1990/07/30
Concluded
|
BSc (Hons) Zoology (Bachelor)
University of Bristol, United Kingdom
"Functional studies of bill-wiping behaviour in the starling (Sturnus vulgaris L.)" (THESIS/DISSERTATION)
|
First Class Honours |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2019/07/01 - Current | Contracted Researcher (Research) | Faculdade de Ciencias, Universidade de Lisboa, Portugal |
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
Teaching in Higher Education
Category Host institution |
Employer | |
---|---|---|
2015/09/01 - 2019/06/30 | Invited Assistant Professor (University Teacher) | Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal |
2016 - 2018 | Invited Assistant Professor (University Teacher) | Universidade de Lisboa, Portugal |
2015 - 2016 | Assistant Professor (University Teacher) | Universidade de Lisboa Faculdade de Ciências, Portugal |
2013 - 2015 | Invited Assistant Professor (University Teacher) | Universidade de Lisboa Faculdade de Ciências, Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2015/06/15 - 2017/12/31 | Investigador em Regime Especial | Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
2009/06/15 - 2015/05/15 | Investigador Ciência 2008 | Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2024/04/01 - 2028/03/31 | - ORGESTRA – HORIZON-MSCA-DN-2022
101120108 - ORGESTRA – HORIZON-MSCA-DN-2022
Co-Principal Investigator (Co-PI)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
|
|
2024/01/01 - 2024/08/31 | CF-Splice: an ASO based strategy to correct a population specific CFTR splicing variant.
CF-Splice
Principal investigator
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
|
Emily's Entourage
Ongoing
|
2020/01/01 - 2020/12/31 | PTsense - novel compounds as potential drugs for CFTR PTC mutations
AMARAL19G0
Co-Principal Investigator (Co-PI)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
Cystic Fibrosis Foundation Therapeutics Inc
Ongoing
|
2006/09/01 - 2009/09/01 | Development of a complete integrated SNP analysis system.
STRP016833
Research Fellow
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
Concluded
|
2005/06/01 - 2006/06/01 | Novel magnetoresistive gene chips for Cystic Fibrosis diagnosis
SFRH/BPD/20730/2004
Post-doc Fellow
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
|
2002/06/01 - 2005/06/01 | Use of novel magnetoresistive gene chip technology for development of diagnostic arrays: use of Cystic Fibrosis as a model
QLK3-CT-2001-01982
Research Fellow
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
|
2000/12/01 - 2002/06/01 | Characterization of the mutagenic effects of poly (ADP-ribose) polymerase deficiency in transgenic mice
34270/99
Post-doc Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
|
Fundação para a Ciência e a Tecnologia |
1997/09/01 - 2000/09/01 | Identification and characterization of mutations in genes critical for colorectal cancer.
2/2.1/SAL/1397/95
Post-doc Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
1993/09/01 - 1997/09/01 | Physiological function of prolactin based on studies of receptor gene expression in the red deer
BBSRC
PhD Student Fellow
Institute of Zoology of the Zoological Society of London, United Kingdom
|
Biotechnology and Biological Sciences Research Council
Concluded
|
Contract
Designation | Funders | |
---|---|---|
2018/01/01 - 2019/06/30 | RNA Life - Novel RNA regulators as potential drug targets for CF
AMARAL15XX1
Research Fellow
|
Cystic Fibrosis Foundation Therapeutics Inc
Concluded
|
2015/06/01 - 2017/12/31 | Evaluation of CFTR mutations bearing Premature Termination Codons: NMD susceptibility
7207534
Research Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
Cystic Fibrosis Foundation Therapeutics Inc |
Other
Designation | Funders | |
---|---|---|
2014/01/01 - 2014/12/31 | Explorando o controle de qualidade do retículo endoplasmático - interacções proteicas como novos alvos terapêuticos na Fibrose
Quística
EXPL/BIM-MEC/1451/2013
Other
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
Fundação para a Ciência e a Tecnologia |
2008/01/01 - 2008/12/31 | Development of new methodologies for low abundance proteomics: application to cystic fibrosis
FP6-2003-LIFESCIHEALTH-2512044
Researcher
|
Concluded
|
Outputs
Publications
Book chapter |
|
Conference paper |
|
Journal article |
|
Activities
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2022/03/02 | Optimising mRNA integrity and read-through of CFTR bearing PTC mutations.
Supervisor
|
VANESSA CRISTINA DE CARVALHO LUZ (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2019/09/20 | Regulation of glucose uptake in mammalian cells by protein phosphorylation networks
Supervisor
|
andreia filipa almeida henriques (PhD) |
2019/06/01 | Information Retrieval using Machine Learning for Database Curation
(Thesis) Main arguer
|
sofia pinheiro rodrigues de jesus (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2019/05/03 | Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks
Supervisor
|
cláudia almeida loureiro (PhD) |
2019/02/08 | Development of a text mining approach to disease network discovery
Supervisor
|
andré francisco martins lamúrias (PhD)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2018/06/01 | Identifying the sequence complexity of miRNAs and their functional impact in small-RNA-seq data
(Thesis) Main arguer
|
inês correia viegas (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2017/06/01 | Single domain antibodies association to lipid-guide drug delivery as an innovative therapeutic strategy against cancer stem
cells
(Thesis) Main arguer
|
ana carolina malho sousa (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2017/03/01 | Previsão da Localização Subcelular de Proteínas Humanas com base em Aprendizagem Automática
(Thesis) Main arguer
|
pedro de almeida martins (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2017/03/01 | Lab on a chip for Cystic Fibrosis
Supervisor
|
Anna Pedrola Gómez (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
2017/02/15 | Validação de genes alvo da via Rac1/PAK1-BCL6/STAT5 envolvidos na progressão tumoral
(Thesis) Main arguer
|
leonor bárbara freire abrantes (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2016/11/23 | Development of a miniaturized chip for personalized therapy of cystic fibrosis
Supervisor
|
Rafaela Furtado Pereira (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
2015/11/27 | Effect of TGFß signalling on CFTR protein: consequences for epithelial differentiation in CF
Supervisor
|
Margarida Quaresma (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2015/06/01 | Estudos dos efeitos do tratamento com rhHGF de células epiteliais brônquicas derivadas de doentes com Fibrose Quística: avaliação
das propriedades regenerativas versus oncogénicas
(Thesis) Main arguer
|
Andreia Duarte (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2015/05/05 | Functional coherence and annotation agreement metrics for enzyme families
Supervisor
|
Hugo Bastos (PhD)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2014/09/26 | Identifying interactions between chemical entities in text
(Thesis) Main arguer
|
André Lamurias (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2012/04/05 | Role of Ubiquitin Ligases in Pathophysiology of Cystic Fibrosis
Supervisor
|
Sara Canato (Master)
Faculdade de Ciencias, Universidade de Lisboa, Portugal
|
2009/06/01 | A Magnetoresistive Biochip Platform: detection of DNA hybridization and antibody/cell recognition
(Thesis) Main arguer
|
verónica cristina baião martins romão (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2010/01/01 - 2024/08/01 | Human Molecular Biology (Year 3 Biochemistry/ Masters in Health Sciences) | Human Molecular Biology (Mestrado) | Faculdade de Ciencias, Universidade de Lisboa, Portugal |
2009/09/01 - 2024/02/15 | Molecular Biology (Year 3, Biochemistry) | Molecular Biology (Licenciatura) | Faculdade de Ciencias, Universidade de Lisboa, Portugal |
2016/07/01 - 2019/07/31 | Workshop: Epithelial Systems: Physiology & Pathophysiology | (Pós-doutoramento) | Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
2013/01/01 - 2018/07/31 | BioSYS PhD Programme | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
2011/09/01 - 2014/07/01 | Biochemistry I (Health Sciences) | (Licenciatura) | Faculdade de Ciencias, Universidade de Lisboa, Portugal |
2011/09/01 - 2013/07/01 | Experimental Biochemistry II | (Licenciatura) |
Distinctions
Award
2019 | Thomé Villar/Boehringer Ingelheim Prize (Team member) |
2013 | 2013 Pfizer Research Award (Team Member) |
1990 | Rose-Bracher Memorial Prize, awarded to best final year student in Zoology
University of Bristol, United Kingdom
|