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Bruno Victor graduated in Biochemistry from the Faculty of Sciences and Technology of the University of Coimbra in 2001. After two years as a research student, under the supervision of Claudio Soares, he started his PhD at ITQB-UNL. At that time, his project consisted of using different molecular modeling methods to study electron transfer proteins involved in the O2 and NO metabolism. After completing his PhD in biochemistry, he continued at ITQB-UNL where he started a Post-Doc project, focused on the study of the functional activity of hemagglutinin and several of its functional peptides in the infection of Influenza Viruses. During this period, with an HPC Europe 2 fellowship, he was also a visiting researcher at Xavier Daura Lab in Barcelona, where he had the opportunity to work with outstanding computational resources, such as the Barcelona Supercomputer. In 2012, he joined BSIM Therapeutics as a computational research scientist, to develop new methods and approaches (from chemoinformatics to Quantum Mechanics) to improve the identification and development of new therapeutic agents to treat Transthyretin-related amyloid diseases. During this period, he was involved not only in this company’s work but also in multiple drug discovery projects (from target and lead identification and validation, to in vitro evaluation) as an outsourced computational scientist, collaborating with different small biotech and drug discovery companies (GenePrediT and BiosolveIT). Although the results of some of those projects did not evolve into real applications, some others are still under development. One such promising example is the work I contributed to the development of a set of new therapeutic agents to prevent the formation of ATTR fibril formation in the peripheral and central nervous system. After this period in industry, he continued to develop his research focused on multiple drug discovery projects, in different academic groups, ranging from the University of Coimbra to the University of Lisbon. Between 2019 and 2023 he was an auxiliary researcher at the BioISI research center, where he coordinated the Structure-based drug discovery research group. During this time he supervised 1 Post-Doc, 3 PhD students, 13 Master thesis, and 5 undergraduate students. Under his supervision, the team has been involved in multiple drug discovery projects. During this time he coordinated several competitively funded projects by FCT (PTDC/BIA-BFS/28419/2017 - development of innovative methods to identify membrane Pan-Assay Interference Compounds (PAINS), and BioISI (BioISI projects call – 2020 - study of post-translational modifications in different metabolic enzymes). He also was part of other FCT-funded projects as part of the team, always responsible for the coordination of the computational work (PTDC/QEQ-MED/29036/2017 and PTDC/QUI-QFI/28455/2017). Moreover, he was involved in two collaborative projects with two international companies developing software tools for drug discovery (Lhasa and BiosolveIT), which are part of the PhD and Master projects of two of his students. In 2023 he joined Zymvol Biomodeling, a biotech company dedicated to protein discovery and engineering, with biotechnological applications. In May 2024 he decided to move to CoLAB AccelBio, to lead the computational medicinal chemistry research department to help setup and develop ongoing drug discovery projects Overall, he published 33 papers in specialized journals and he has registered 3 patents. His research is focused on Natural Sciences with an emphasis on Computational Biochemistry, Biophysics, and Medicinal Chemistry. During his professional activities, he has interacted and collaborated with 105 collaborator(s) during his scientific work.
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Identification

Personal identification

Full name
Bruno Lourenço da Silva Víctor

Citation names

  • Victor, Bruno

Author identifiers

Ciência ID
5A17-09B5-48A5
ORCID iD
0000-0002-6472-5700
Researcher Id
L-2649-2016
Scopus Author Id
8791713500

Email addresses

  • bvictor@accelbio.pt (Professional)

Addresses

  • BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, C8 building, 1749-016, Lisboa, Lisboa, Portugal (Professional)
  • Colab Accelbio, Biocant Park, Parque Tecnológico de Cantanhede, 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Italian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007/11/29
Concluded
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Molecular modelling of redox proteins involved in the metabolism of O2 and NO" (THESIS/DISSERTATION)
 Aprovado
2001/10/20
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Interacção Molecular de Proteínas em Desulfovibrio gigas" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - 2023/05/31 Auxiliary Researcher (Research) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2017/10/01 - 2018/12/31 Postdoc (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017/10/01 - 2018/12/31 Postdoc (Research) iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Portugal
iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Portugal
2016/07/01 - 2017/09/30 Postdoc (Research) Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2015/01/01 - 2016/06/30 Postdoc (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2014/12/01 - 2016/06/30 Postdoc (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2012/10/01 - 2015/01/30 Researcher (Research) BSIM2 Biomolecular Simulations Lda, Portugal
2008/01/01 - 2012/09/30 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008/01/01 - 2012/09/30 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023/06/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Positions / Appointments

Category
Host institution 		Employer
2023/06/01 - 2024/04/30 Senior Researcher Zymvol Biomodeling, Lda, Spain

Others

Category
Host institution 		Employer
2024/05/01 - Current Computational Medicinal Chemist Colab Accelbio, Portugal
2003/02/01 - 2007/11/30 PhD student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2001/11/01 - 2003/01/31 Research Student (BIC) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2000/10/01 - 2001/09/30 Final Year Research Student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projects

Grant

Designation Funders
2022/01/01 - 2024/12/31 Exploring respiratory proteins from human bacterial pathogens
PTDC/BIA-BQM/2599/2021
Researcher
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2024/01 - 2024/12 Expanding the “toolbox” of medicinal chemists: the role of halogen bonds in membrane permeability
2023.10475.CPCA
 Fundação para a Ciência e a Tecnologia
2022/02/01 - 2023/01/31 Structure-based database screening to support decision-making for endocrine disruptor identification
2021.09731.CPCA
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2022/09/01 - 2022/09/30 A natural polyphenol as a promising compound for cancer treatment
UIDP/04046/VerãoComCiência-2022
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas

Fundação para a Ciência e a Tecnologia
Concluded
2020/02/01 - 2021/03/31 Multidisciplinary approach to study post-translational modifications in metabolic enzymes
BioISI Projects call 2020
Principal investigator
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas
Ongoing
2016/10/01 - 2018/09/30 CpHMD-L simulations of pHLIP peptides: design of new tumor-targeted drug delivery systems
PTDC/QEQ-COM/5904/2014
Post-doc Fellow
Concluded
2014 - 2015 Diagnosis and treatment of three neurodegenerative diseases (Parkinson, Phenylketonuria and TTR amyloidosis)
NEUROMED
Post-doc Fellow
Universidade de Coimbra, Portugal
Concluded

Contract

Designation Funders
2022/01/01 - 2024/12/31 Investigação de proteinas respiratorias de patogenos humanos bacterianos
PTDC/BIA-BQM/2599/2021
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/09/30 Em busca de novos derivados de isoniazida eficazes no combate à tuberculose multi-resistente: uma abordagem integrada de química medicinal
PTDC/MED-QUI/29036/2017
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Targeting multi-resistant tuberculosis with new potent isoniazid derivatives: an integrated medicinal chemistry approach
PTDC/QEQ-MED/29036/2017
Researcher
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
Ongoing
2018/10 - 2021/09 Deal with PAINS: strategies to spot membrane modulators
PTDC/BIA- BFS/28419/2017
Principal investigator
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Uncovering blind spots in halogen bonding applications
PTDC/QUI-QFI/28455/2017
Researcher
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
Ongoing
2019/01/01 - 2019/12/31 Centro de Química - Coimbra
UID/QUI/00313/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Research Institute for Medicines
UID/DTP/04138/2019
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2018 Research Institute for Medicines Strategic Plan - 2013/2015 - OE
UID/DTP/04138/2013
Post-doc Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Concluded
2011/03 - 2014/08 Membrane fusion mechanism of Influenza Hemagglutinin: a simulation and biophysical approach.
Provided by PTCRIS: 114774
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2008/01 - 2011/11 Microbial enzymes involved in superoxide and nitric oxide reduction
Provided by PTCRIS: 67263
 Fundação para a Ciência e a Tecnologia, I.P.
2000/10 - 2002/06 Structure function relationships of serine hydrolases in non-conventional media
PRAXIS XXI project PRAXIS/P/BIO/14314/1998
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Victor, Bruno. "Identification of Pan Assay INterference compoundS (PAINS) using an MD-Based Protocol". In Computational Design of Membrane Proteins, edited by Irina S. Moreira. United States: Springer US, 2021.
    In press
Conference abstract
  1. Joana V. Ribeiro; P. R. Magalhães; Joana F Ferreira; Faustino, Hélio; Pedro Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara. "Biochemical studies on the effect of non-enzymatic succinylation of electron transfer flavoprotein". Paper presented in FEBS OPEN BIO, 2022.
    Published
  2. Ferreira, Sara; Victor, Bruno. "Improving the druggability of Aquaporin-1 for future drug discovery campaigns". Paper presented in EJIBCE 2019, Lisbon, 2020.
    Published • 10.3390/mol2net-05-06774
Conference poster
  1. Bahls, Bárbara; Emídio, Rita; Victor, Bruno; Cruz, Carla; Figueiredo, Joana; Paulo, Alexandra. Corresponding author: Bahls, Bárbara. "c-MYC G-quadruplex stabilization by 5-amino-8-chloro-11H-indolo[3,2-c]isoquinoline derivatives: in vitro and in silico studies.". Paper presented in 15th ENQO & 8th ENQT, 2024.
  2. Joana V. Ribeiro; Magalhães, Pedro R.; Faustino, Hélio; Pedro M. P. Góis; Victor, Bruno; Cláudio M. Gomes; Henriques, Bárbara J. "Potential regulatory role of succinylation on electron transfer flavoprotein, a key protein in mitochondrial metabolism". Paper presented in EBSA Congress 2023, 2023.
  3. Farinha, B; Brígido, Ana; Simão, AL; Victor, Bruno; Castro, Rui. "Unveiling the Functional Role of TGR5 in Fat-to-Liver Communication: Discovery of Novel Agonists". Paper presented in 3rd Chem&BioChem Students Meeting, 2023.
  4. Brígido, Ana; Farinha, B; Simão, AL; Fernandes, DAE; Henrique, Mariana; Costa-Silva, Bruno; Victor, Bruno; Castro, Rui. "Functional role of TGR5 in fat-to-liver communication during non-alcoholic fatty liver disease". Paper presented in 2nd Meeting of the Portuguese Network on Extracellular Vesicles, 2023.
  5. Farinha, B; Brígido, Ana; Simão, AL; Victor, Bruno; Castro, Rui. "Unveiling Promising TGR5 Agonists for NAFLD Treatment through Structure-Based Virtual Screening". Paper presented in 14th iMed.ULisboa Meeting, 2023.
  6. Farinha, B; Brígido, Ana; Simão, AL; Victor, Bruno; Castro, Rui. "Structure-based virtual screening campaign identifies novel potential TGR5 agonists for the treatment of obesity-associated NAFLD". Paper presented in Jornadas Científicas da ULisboa, 2023.
  7. Farinha, B; Simão, AL; Castro, RE; Victor, Bruno. "Structure-based virtual screening campaign identifying new promising TGR5 agonists to treat obesity-associated NAFLD". Paper presented in LEAPS Meets Life Sciences Conference, 2023.
  8. Emídio, Rita; Paulo, Alexandra; Victor, Bruno. "Molecular docking and synthesis of indoloisoquinoline bioisosters as new cancer therapeutics". Paper presented in 3D-BioInfo-PT Annual Meeting, 2022.
  9. Neto Vasco; Victor, Bruno; Galamba, N.. Corresponding author: Galamba, N.. "Probing the Anti-sickling Power of Distinct Drugs in Sickle Cell Disease". Paper presented in 3D-BioInfo-PT Meeting, 2022.
  10. Joana V. Ribeiro; Magalhães, Pedro R.; Joana F. Ferreira; Faustino, Hélio; Pedro M. P. Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara J. "Non-enzymatic succinylation of electron transfer flavoprotein ¿ potential implications on multiple acyl-CoA dehydrogenase deficiency". Paper presented in SSIEM Annual Symposium 2022, 2022.
  11. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Identification, design and synthesis of novel indoloisoquinolines inhibitors of c-myc:G4-helicase interaction". Paper presented in 2nd Chem&BioChem - Universidade de Lisboa, 2022.
  12. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Computer-assisted design of insoloisoquinolines as potential new anticancer drugs". Paper presented in 5MCQUL, 2022.
  13. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Development of c-MYC:G4-helicase interaction inhibitors". Paper presented in 5th Imed Meeting, 2022.
  14. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Computer-assisted design of indoloisoquinoline as potential DNAG4-Helicase interaction inhibitors". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  15. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. Corresponding author: Magalhães, Pedro R.. "Identification of membrane PAINS via an optimized computational protocol". Paper presented in 8th EJIBCE, Coimbra, Portugal, 2021.
  16. Bahls, Bárbara; Victor, Bruno; Paulo, Alexandra. Corresponding author: Bahls, Bárbara. "Design of Indoloisoquinoline derivatives as potential inhibitors of the interaction between c-MYC:G4 and helicase". Paper presented in EJIBCE, 2021.
    https://doi.org/10.3390/mol2net-07-12112
  17. Marques, Jéssica; Pimpão, Catarina; Victor, Bruno; Soveral, Graça. "Development of new computational workflow for the identification of hAQP5 modulators". Paper presented in VIII EJIBCE, 2021.
  18. Joana V. Ribeiro; Magalhães, Pedro R.; Joana F. Ferreira; Faustino, Hélio; Pedro M. P. Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara J. "Structural impact of succinylation on Electron Transfer Flavoprotein function". Paper presented in 17th International Symposium of SPDM, 2021.
  19. Marques, Jéssica; Pimpão, Catarina; Victor, Bruno; Soveral, G.. "Identification of new human AQP5 inhibitors using computational and experimental approaches". Paper presented in iMed.ULisboa Meeting 2021, 2021.
  20. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. Corresponding author: Magalhães, Pedro R.. "Development of a Novel Computational Protocol for the Identification of Membrane PAINS". Paper presented in Computer Simulation and Theory of Macromolecules, Hunfeld Online Workshop, 2021.
  21. Ferreira, Sara; Victor, Bruno. "Targeting Aquaporin-1 to Identify New Anti-Cancer Therapies". Paper presented in Hünfeld 2021: Workshop on Computer Simulation and Theory of Macromolecules, 2021.
  22. Marques, Jéssica; Soveral, Graça; Victor, Bruno. "Screening of aquaporin-5 modulators with anticancer properties". Paper presented in Hünfeld 2021: Workshop on Computer Simulation and Theory of Macromolecules, 2021.
  23. Marques, Jéssica; Pimpão, Catarina; Victor, Bruno; Soveral, Graça. "Identification of new and innovative human AQP5 inhibitors using computational and experimental approaches". Paper presented in Imed.ULisboa meeting, 2021.
  24. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Speeding-up the identification of membrane PAINS with a new computational approach". Paper presented in Ciências Research Day, 2020.
  25. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Refining an umbrella-sampling protocol to describe membrane PAINS". Paper presented in EJIBCE 2019 (7th Encontro de Jovens Investigadores de Biologia Computacional Estrutural), Lisboa, Portugal, 2019.
  26. Magalhães, Pedro R.; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Structural characterization of Aquaporin-1 and evaluation of a PMF based protocol to determine water permeability rates". Paper presented in EJIBCE 2019 (7th Encontro de Jovens Investigadores de Biologia Estrutural Compucacional), Lisboa, Portugal, 2019.
  27. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Computational Characterization of Membrane PAINS". Paper presented in Joint 12th EBSA 10th ICBP-IUPAP Biophysics Congress, Madrid, Spain, 2019.
  28. Magalhães, Pedro R.; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Computational prediction of water permeability rates in Aquaporin-1". Paper presented in Joint 12th EBSA congress 10th ICBP-IUPAP Congress, Madrid, Spain, 2019.
  29. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Optimization of a computational protocol to characterize membrane PAINS". Paper presented in Workshop on Integrative Approaches to Protein Folding & Aggregation, Lisboa, Portugal, 2019.
  30. Silva, Tomás F.D.; Reis, Pedro B P S; Victor, Bruno; Vila-Viçosa, Diogo; Machuqueiro, Miguel. "Evaluating GROMOS force fields without the twin-range cutoff scheme". Paper presented in Free Energy Calculations from Molecular Simulation: Aplications in Life and Medical Sciences, 2017.
  31. Lopes, Ana; Simões, C. J. V.; Brito, R.M.M.; Dora, D.C.S.; Victor, Bruno; Bruno F. O. Nascimento; Pinho e Melo, T.M.V.D.. "AMILOTERA ¿ Discovery and optmization of novel therapeutic agents against transthyretyn-related amyloid diseases". Paper presented in Young Researchers Meeting of Computational Structural Biology, Porto, Portugal, 2013.
Journal article
  1. Vasco Neto; Bruno Lourenço Victor; Nuno Galamba. "Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease". Journal of Medicinal Chemistry (2023): https://doi.org/10.1021/acs.jmedchem.3c01484.
    10.1021/acs.jmedchem.3c01484
  2. Tiina J. Ahonen; Choa P. Ng; Beatriz Farinha; Bárbara Almeida; Bruno L. Victor; Christopher Reynolds; Eija Kalso; et al. "Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12". ACS Medicinal Chemistry Letters (2023): https://doi.org/10.1021/acsmedchemlett.3c00313.
    10.1021/acsmedchemlett.3c00313
  3. Inês Paccetti-Alves; Marta S. P. Batista; Catarina Pimpão; Bruno L. Victor; Graça Soveral. "Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24066004.
    10.3390/ijms24066004
  4. Sónia Zacarias; Marta S. P. Batista; Sofia S. Ramalho; Bruno L. Victor; Carlos M. Farinha. "Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043211.
    10.3390/ijms24043211
  5. Claudia Istrate; Jéssica Marques; Pedro Bule; Sílvia Correia; Frederico Aires-da-Silva; Marlene Duarte; Ana Luísa Reis; et al. "In Silico Characterization of African Swine Fever Virus Nucleoprotein p10 Interaction with DNA". Viruses (2022): https://doi.org/10.3390/v14112348.
    10.3390/v14112348
  6. Pedro R. Magalhães; Pedro B. P. S. Reis; Diogo Vila-Viçosa; Miguel Machuqueiro; Bruno L. Victor. "Optimization of an in Silico Protocol Using Probe Permeabilities to Identify Membrane Pan-Assay Interference Compounds". Journal of Chemical Information and Modeling (2022): https://doi.org/10.1021/acs.jcim.2c00372.
    10.1021/acs.jcim.2c00372
  7. María Conde-Giménez; Juan José Galano-Frutos; María Galiana-Cameo; Alejandro Mahía; Bruno L. Victor; Sandra Salillas; Adrián Velázquez-Campoy; et al. "Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase". International Journal of Molecular Sciences 23 9 (2022): 4502-4502. https://doi.org/10.3390/ijms23094502.
    10.3390/ijms23094502
  8. Mendes, Eduarda; Aljnadi, Israa M.; Bahls, Bárbara; Victor, Bruno L.; Paulo, Alexandra. "Major Achievements in the Design of Quadruplex-Interactive Small Molecules". Pharmaceuticals 15 3 (2022): 300. http://dx.doi.org/10.3390/ph15030300.
    10.3390/ph15030300
  9. "In Silico End-to-End Protein–Ligand Interaction Characterization Pipeline: The Case of SARS-CoV-2". ACS Synthetic Biology 10 11 (2021): 3209-3235. http://dx.doi.org/10.1021/acssynbio.1c00368.
    10.1021/acssynbio.1c00368
  10. Enrico Cadoni; Pedro R. Magalhães; Rita M. Emídio; Eduarda Mendes; Jorge Vítor; Josué Carvalho; Carla Cruz; Bruno L. Victor; Alexandra Paulo. "New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study". Pharmaceuticals 14 7 (2021): 669-669. https://doi.org/10.3390/ph14070669.
    10.3390/ph14070669
  11. Pires, Filipa; Geraldo, Vananélia P. N.; Rodrigues, Bárbara; Granada-Flor, António de; de Almeida, Rodrigo F. M.; Oliveira, Osvaldo N.; Victor, Bruno L.; Machuqueiro, Miguel; Raposo, Maria. "Evaluation of EGCG Loading Capacity in DMPC Membranes". Langmuir (2019): http://dx.doi.org/10.1021/acs.langmuir.9b00372.
    10.1021/acs.langmuir.9b00372
  12. Silva, T.F.D.; Vila-Viçosa, D.; Reis, P.B.P.S.; Victor, B.L.; Diem, M.; Oostenbrink, C.; Machuqueiro, M.. "The Impact of Using Single Atomistic Long-Range Cutoff Schemes with the GROMOS 54A7 Force Field". Journal of Chemical Theory and Computation (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85056302174&partnerID=MN8TOARS.
    10.1021/acs.jctc.8b00758
  13. Gaspar, H.; Bronze, S.; Oliveira, C.; Victor, B.L.; Machuqueiro, M.; Pacheco, R.; Caldeira, M.J.; Santos, S.. "Proactive response to tackle the threat of emerging drugs: Synthesis and toxicity evaluation of new cathinones". Forensic Science International 290 (2018): 146-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050077249&partnerID=MN8TOARS.
    10.1016/j.forsciint.2018.07.001
  14. Lousa, Diana; Pinto, Antonia R. T.; Victor, Bruno L.; Laio, Alessnadro; Veiga, Ana S.; Castanho, Miguel A. R. B.; Soares, Claudio M.. "Molecular determinants of the influenza fusion peptide activity". Free Radical Biology and Medicine 120 (2018): S125-S125. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432836500398&KeyUID=WOS:000432836500398.
    10.1016/j.freeradbiomed.2018.04.413
  15. Machuqueiro, M.; Victor, B.; Switala, J.; Villanueva, J.; Rovira, C.; Fita, I.; Loewen, P.C.. "The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKaof the Distal Histidine". Biochemistry 56 17 (2017): 2271-2281. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018989755&partnerID=MN8TOARS.
    10.1021/acs.biochem.6b01276
  16. Vila-Viçosa, D.; Victor, B.L.; Ramos, J.; Machado, D.; Viveiros, M.; Switala, J.; Loewen, P.C.; et al. "Insights on the Mechanism of Action of INH-C10as an Antitubercular Prodrug". Molecular Pharmaceutics 14 12 (2017): 4597-4605. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037617710&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.7b00719
  17. Ressaissi, A.; Attia, N.; Falé, P.L.; Pacheco, R.; Victor, B.L.; Machuqueiro, M.; Serralheiro, M.L.M.. "Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies". Archives of Pharmacal Research 40 11 (2017): 1278-1286. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029697150&partnerID=MN8TOARS.
    10.1007/s12272-017-0959-1
  18. Lousa, D.; Pinto, A. R. T.; Victor, B. L.; Laio, A.; Veiga, A. S.; Castanho, M. A. R. B.; Soares, C. M.. "Molecular determinants of the influenza fusion peptide's activity". European Biophysics Journal With Biophysics Letters 46 (2017): S222-S222. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000416406201299&KeyUID=WOS:000416406201299.
  19. Romão, C.V.; Vicente, J.B.; Borges, P.T.; Victor, B.L.; Lamosa, P.; Silva, E.; Pereira, L.; et al. "Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase". Journal of Molecular Biology 428 23 (2016): 4686-4707. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996538192&partnerID=MN8TOARS.
    10.1016/j.jmb.2016.10.008
  20. Lousa, D.; Pinto, A.R.T.; Victor, B.L.; Laio, A.; Veiga, A.S.; Castanho, M.A.R.B.; Soares, C.M.. "Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84975041212&partnerID=MN8TOARS.
    10.1038/srep28099
  21. Manco, L.; Bento, C.; Victor, B.L.; Pereira, J.; Relvas, L.; Brito, R.M.; Seabra, C.; Maia, T.M.; Ribeiro, M.L.. "Hereditary nonspherocytic hemolytic anemia caused by red cell glucose-6-phosphate isomerase (GPI) deficiency in two Portuguese patients: Clinical features and molecular study". Blood Cells, Molecules, and Diseases 60 (2016): 18-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975485169&partnerID=MN8TOARS.
    10.1016/j.bcmd.2016.06.002
  22. Victor, B.L.; Lousa, D.; Antunes, J.M.; Soares, C.M.. "Self-assembly molecular dynamics simulations shed light into the interaction of the influenza fusion peptide with a membrane bilayer". Journal of Chemical Information and Modeling 55 4 (2015): 795-805. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928686003&partnerID=MN8TOARS.
    10.1021/ci500756v
  23. Lousa, Diana; Victor, Bruno L.; Fernandez, Carlos; Soares, Claudio M.. "Structural Properties of Membrane Inserted Fusion Peptide from Influenza Virus Analysed by Molecular Simulation". Biophysical Journal 106 2 (2014): 53A-53A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337000400274&KeyUID=WOS:000337000400274.
  24. Lousa, D.; Victor, B. L.; Fernandez, C.; Soares, C. M.. "What is the role of the influenza fusion peptide in membrane fusion? A computational study". Febs Journal 281 (2014): 214-214. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359666801408&KeyUID=WOS:000359666801408.
  25. Victor, Bruno L.; Baptista, Antonio M.; Soares, Claudio M.. "Modeling the Structural Properties of the Transmembrane Peptide of Influenza Hemagglutinin in a Membrane Bilayer". Biophysical Journal 106 2 (2014): 53A-53A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337000400275&KeyUID=WOS:000337000400275.
  26. Damas, J.M.; Filipe, L.C.S.; Campos, S.R.R.; Lousa, D.; Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Predicting the thermodynamics and kinetics of helix formation in a cyclic peptide model". Journal of Chemical Theory and Computation 9 11 (2013): 5148-5157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887835236&partnerID=MN8TOARS.
    10.1021/ct400529k
  27. Antunes, J. M.; Victor, B. L.; Soares, C. M.. "Multi-scale simulations of the influenza virus transmembrane peptide in lipid bilayers". European Biophysics Journal With Biophysics Letters 42 (2013): S87-S87. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330215300200&KeyUID=WOS:000330215300200.
  28. Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Structural determinants for the membrane insertion of the transmembrane peptide of hemagglutinin from influenza virus". Journal of Chemical Information and Modeling 52 11 (2012): 3001-3012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870015416&partnerID=MN8TOARS.
    10.1021/ci3003396
  29. Seixas, S.; Ivanova, N.; Ferreira, Z.; Rocha, J.; Victor, B.L.. "Loss and gain of function in SERPINB11: An example of a gene under selection on standing variation, with implications for host-pathogen interactions". PLoS ONE 7 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857664937&partnerID=MN8TOARS.
    10.1371/journal.pone.0032518
  30. Gonçalves S; Borges N; Esteves AM; Victor BL; Soares CM; Santos H; Matias PM. "Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases.". (2010): http://europepmc.org/abstract/med/20356840.
    10.1074/jbc.m109.095976
  31. Gonçalves, S.; Borges, N.; Esteves, A.M.; Victor, B.L.; Soares, C.M.; Santos, H.; Matias, P.M.. "Structural analysis of Thermus thermophilus HB27 mannosyl-3- phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases". Journal of Biological Chemistry 285 23 (2010): 17857-17868. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952938697&partnerID=MN8TOARS.
    10.1074/jbc.M109.095976
  32. Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Dioxygen and nitric oxide pathways and affinity to the catalytic site of rubredoxin: Oxygen oxidoreductase from Desulfovibrio gigas". Journal of Biological Inorganic Chemistry 14 6 (2009): 853-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349289240&partnerID=MN8TOARS.
    10.1007/s00775-009-0497-5
  33. Micaelo, N.M.; Victor, B.L.; Soares, C.M.. "Protein thermal stabilization by charged compatible solutes: Computational studies in rubredoxin from Desulfovibrio gigas". Proteins: Structure, Function and Genetics 72 2 (2008): 580-588. http://www.scopus.com/inward/record.url?eid=2-s2.0-46449090359&partnerID=MN8TOARS.
    10.1002/prot.21948
  34. Rodrigues, J.V.; Victor, B.L.; Huber, H.; Saraiva, L.M.; Soares, C.M.; Cabelli, D.E.; Teixeira, M.. "Superoxide reduction by Nanoarchaeum equitans neelaredoxin, an enzyme lacking the highly conserved glutamate iron ligand". Journal of Biological Inorganic Chemistry 13 2 (2008): 219-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-38649136959&partnerID=MN8TOARS.
    10.1007/s00775-007-0313-z
  35. Teixeira, V.H.; Cunha, C.A.; Machuqueiro, M.; Oliveira, A.S.F.; Victor, B.L.; Soares, C.M.; Baptista, A.M.. "On the use of different dielectric constants for computing individual and pairwise terms in poisson-boltzmann studies of protein ionization equilibrium". Journal of Physical Chemistry B 109 30 (2005): 14691-14706. http://www.scopus.com/inward/record.url?eid=2-s2.0-23844500381&partnerID=MN8TOARS.
    10.1021/jp052259f
  36. Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Theoretical identification of proton channels in the quinol oxidase aa3from Acidianus ambivalens". Biophysical Journal 87 6 (2004): 4316-4325. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044240740&partnerID=MN8TOARS.
    10.1529/biophysj.104.049353
  37. Victor, BL; Baptista, AM; Soares, CM. "Study of proton channels in the quinol oxidase (aa3) from acidianus ambivalens using theoretical methodologies". Biochimica Et Biophysica Acta-Bioenergetics 1658 (2004): 173-173. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000223500600228&KeyUID=WOS:000223500600228.
  38. Victor, BL; Vicente, JB; Rodrigues, R; Oliveira, S; Rodrigues-Pousada, C; Frazao, C; Gomes, CM; Teixeira, M; Soares, CM. "Docking and electron transfer studies between rubredoxin and rubredoxin : oxygen oxidoreductase". Journal of Biological Inorganic Chemistry 8 4 (2003): 475-488. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000183036300012&KeyUID=WOS:000183036300012.
    10.1007/s00775-002-0440-5
Online resource
  1. Henriques, Bárbara J; Victor, Bruno; Joana Valente Ribeiro. Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) | Rare Disease Day 2023 (Public Outreach Institucional video). 2023. https://www.youtube.com/watch?v=8-2E6l26V8g.

Intellectual property

Patent
  1. Victor, Bruno. 2016. "Genetic markers and treatment of male obesity". United States.
  2. Victor, Bruno. 2016. "SMALL MOLECULE TRANSTHYRETIN STABILIZERS AND USES THEREOF". United States.
  3. Victor, Bruno. 2016. "2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF". United States.

Other

Other output
  1. Optimization of an in silico protocol to characterize membrane PAINS. 2021. Pedro R. Magalhães; Pedro B. P. S. Reis; Diogo Vila-Viçosa; Miguel Machuqueiro; Bruno L. Victor. https://doi.org/10.26434/chemrxiv-2021-t036h.
    10.26434/chemrxiv-2021-t036h
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/12/20 Computational campaign to discover novel human 20S proteasome inhibitors MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition, EJIBCE-02
(Coimbra, Portugal)
2018/12/20 The impact of using single atomistic long range cutoff schemes with the GROMOS 54A7 force field. EJIBCE 2018 meeting
(Porto, Portugal)
2017/07/21 Mutations in the katG heme pocket modulate local electrostatics and impair INH activation Colágio da Química - 2017
(Lisboa, Portugal)
2017/07 P. Reis, T. Silva, B. Victor, D. Vila-Viçosa and M. Machuqueiro, “pKa shifts in protein and membrane binding” Free Energy Calculations from Molecular Simulation Workshop
(London, United Kingdom)
2015/11/20 A química computacional no desenvolvimento de novos agentes terapêuticos Encontro Científico NEQ/AAC
(Coimbra, Portugal)
2015/09/25 Predicting affinity in protein-ligand complexes Summer School in Computational Biology
(Coimbra, Portugal)
2014/10/31 A new theoretical approach to study proton channels in the Quinol Oxidase aa3 from Acidianus ambivalens 3rd Portuguese-Spanish Biophysics Congress
(Lisboa, Portugal)
2014/10/15 Proton channels in the quinol oxidase from Acidianus ambivalens SCAN seminars at ITQB-UNL
(Oeiras, Portugal)
2013/12/22 Binding Free Energy calculations of different series of hits to TTR protein EJIBCE 2013
(Lisboa, Portugal)
2010/10/04 Molecular Modeling of hemagglutinin from Influenza Virus INTERBIO - Barcelona Innovation workshops: NanoBiotechnology & IT for life sciences and medicine
(Barcelona, Spain)
2007/11/26 Molecular modelling of redox proteins involved in the oxygen and nitric oxide metabolism ITQB-UNL
(Oeiras, Portugal)
2001/09/18 Modelação Molecular da interacção de proteínas em Desulfovibrio gigas Apresentação de Tese de Licenciatura - Universidade de Coimbra
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Unclothing the dichotomic pH regulation in aquaporin-7 and aquaporin-10.
Supervisor of Marta Batista
 PhD in theoretical biochemistry (PhD)
2022/09/01 - Current A computational study on the impact of adding anionic groups to tyrosine kinase inhibitors
Co-supervisor
 MsC in computational biology (Master)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2022/09/01 - Current Probing the Anti-Sickling Power of Distinct Drugs in Sickle Cell Disease
Co-supervisor
 MsC in biochemistry and biomedicine (Master)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2020/09/01 - Current Aquaporin inhibitors with anticancer properties - computational screening and functional validation
Supervisor
 Biochemistry (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09/01 - Current Ligand and structure-based computational drug discovery of innovative Aquaporin modulators
Supervisor
 Bioinformática e Biologia Computacional (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09/01 - Current Modelação por Homologia da proteína Aquaporin 7
Supervisor
 Bioquímica (Degree)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09/01 - Current Estudos computacionais na Aquaporin-3 e a implicação da sua função no envelhecimento humano
Supervisor
 Bioquímica (Degree)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/06/01 - 2025/05/31 Development of G4 DNA-Helicase Interaction Inhibitors
Co-supervisor
 Química Farmacêutica e Terapêutica (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/02/01 - 2025/01/31 Towards a framework to unify in silico methods to support decision-making for chemical risk assessments: application in endocrine disruptors
Supervisor
 Theoretical Biochemistry (PhD)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2022/09/01 - 2023/12/21 Optimization and synthesis of indoloisoquinoline derivatives as new anticancer therapeutics
Co-supervisor
 PhD in medicinal chemistry and biopharmaceutics (Master)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2022/09/01 - 2023/12/20 Structural characterization and identification of novel inhibitors of respiratory proteins from human bacterial pathogens
Supervisor
 MsC in Bioorganic Chemistry (Master)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2022/09/01 - 2023/11/16 Structural Characterization and Functional Role of TGR5 in Adipose Tissue – Liver Axis in the context of Non-Alcoholic Fatty Liver Disease
Co-supervisor
 MsC in biopharmaceutical sciences (Master)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2021/09/01 - 2022/08/31 Improved drug discovery: towards an energy-based criterion to characterize protein-ligand interactions
Co-supervisor
 Biochemistry | Medical Biochemistry (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/09/01 - 2022/08/31 Development of a new hybrid therapeutic agent against malaria by targeting the Aquaglyceroporin from plasmodium spp
Supervisor
 Bioinformatics and Computational Biology (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/09/01 - 2022/08/31 Computer-assisted design and synthesis of DNA-G4/helicase interaction inhibitors
Co-supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/03/01 - 2018/06/30 Structural characterization of Aquaporin-4 using Molecular Dynamics simulations
Co-supervisor
 iMED PhD program (PhD)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/09/01 - 2016/05/04 Modelação molecular/bioinformática estrutural da hemaglutinina do Virús Influenza
Co-supervisor
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/09/01 - 2016/01/11 Em busca de determinantes estruturais no reconhecimneto e ligação de amilóide: beta-2 microglobulina como caso de estudo
Co-supervisor
 Química Terapêutica (Master)
Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/12/20 - 2019/12/20 EJIBCE 2019 (2019/12/20 - 2019/12/20)
Conference (Member of the Organising Committee)
2015/12/22 - 2015/12/22 Organização do EJIBCE 2015 (2015/12/22 - 2015/12/22)
Conference (Member of the Organising Committee)
2008/07/04 - 2008/07/06 Organizing Committee of the 1st Portuguese-Spanish-British Joint Biophysics Congress (2008/07/04 - 2008/07/04)
Conference (Member of the Organising Committee)
 Universidade Nova de Lisboa Unidade de Ensino e Investigação em Saúde Pública Internacional e Bioestatística, Portugal
2007/10/01 - 2007/10/01 Organizing Committee of the 7h Short Course of the Portuguese Biophysical Society “Biospectroscopy and Imaging” (2007/10/01 - 2007/10/01)
Congress (Member of the Organising Committee)
 Instituto Politécnico de Santarém, Portugal
2005/10/01 - 2005/10/01 Organizing Committee of the 6th Short Course of the Portuguese Biophysical Society “From Membrane Transport to Neurosciences: a Biophysical Perspective” (2005/10/01 - 2005/10/01)
Conference (Member of the Organising Committee)
 Instituto Politécnico de Santarém, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/12/20 - Current Pedro R. Magalhães, Diogo Vila-Viçosa, Miguel M. Machuqueiro, Bruno L. Victor "Structural characterization of Aquaporin-1 and evaluation of a PMF based protocol to determine water permeability rates", Poster Presentation
Congress
 EJIBCE 2019
2019/12/20 - Current Sara Ferreira, Bruno L. Victor "Combined ligand and structure-based computational drug discovery of innovative Aquaporin modulators", Poster Presentation
Congress
 EJIBCE 2019
2019/12/20 - Current Pedro Magalhães, Pedro Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor "Refining an umbrella-sampling protocol to describe membrane PAINS", Poster presentation
Congress
 EJIBCE 2019
2019/07/20 - Current Pedro R. Magalhães, Diogo Vila-Viçosa, Miguel M. Machuqueiro, Bruno L. Victor, "Evaluation of different computational approaches to measure water permeabilities in Aquaporins", Poster Presentation Joint 12th EBSA-10th ICBP-IUPAP Biophysics Congress
2019/07/20 - Current Pedro R. Magalhães, Pedro B. P. S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor, "Pedro R. Magalhães, Pedro B. P. S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor", Poster presentation
Congress
 Joint 12th EBSA-10th ICBP-IUPAP Biophysics Congress
2019/07/19 - Current Pedro R. Magalhães, Pedro B.P.S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor "Optimization of a computational protocol to characterize membrane PAINS", Poster Presentation INTEGRATIVE APPROACHES TO PROTEIN FOLDING & AGGREGATION
2019/07/11 - Current Pedro Magalhães , Diogo Vila-Viçosa , Miguel Machuqueiro , Bruno L. Victor "Computational prediction of water permeability rates in Aquaporin-1"
Congress
 Workshop on Integrative approaches to protein folding and aggregation
2017/05 - Current T. Silva, P. Reis, B. L. Victor, D. Vila-Viçosa and M. Machuqueiro, “Evaluating GROMOS force fields without the twin-range cutoff scheme”
Congress
 Free Energy Calculations from Molecular Simulation Workshop
2017/05 - Current B. L. Victor, D. Vila-Viçosa, F. Martins, P. Loewen, M. Machuqueiro, “KatG S315 mutations modulate local electrostatics impairing INH activation”
Congress
 Free Energy Calculations from Molecular Simulation Workshop
2016/12 - Current B. L. Victor, D. Vila-Viçosa, P. Loewen, M. Machuqueiro, “pKa calculations in the heme pocket of KatG during its catalytic cycle”
Congress
 EJIBCE 2016
2015/12/18 - Current Pedro Fernandes, Bruno L. Victor, Cândida Silva, Rui Brito, "Characterization of the ß2m-ThT complex using molecular dynamics and alchemical free energy calculations
Congress
 EJIBCE 2015
2015/12/01 - Current Pedro M. P. Fernandes, Bruno L. Victor, Candida G. Silva, Rui M.M. Brito, 2015, Application of Molecular Dynamics and Alchemical Free Energy Calculations to study the interaction of ß-2 microglobulin with thioflavin-T
Congress
 Congresso Química Orgânica e Química Terapêutica
2015/06/10 - Current Pedro M. P. Fernandes, Bruno L. Victor, Candida G. Silva, Rui M. M. Brito, 2015, Searching for structural determinants in amyloid recognition and binding
Congress
 6th European Conference Chemistry in the Life Sciences
2014/12/19 - Current Pedro M. P. Fernandes, Bruno L. Victor, Cândida G. Silva, Rui M.M. Brito "Searching for structural determinants in amyloid recognition and binding"
Congress
 Second Portuguese Young Researchers in Computational Structural Biology Meeting
2014/12/17 - Current Pedro M. P. Fernandes, Bruno L. Victor, Cândida G. Silva, Rui M.M. Brito (2014) Molecular docking and molecular dynamics studies of the interaction of ThT with ß2-microglobulin
Conference
 XVIII Congress of the Portuguese Biochemichal Society
Universidade de Coimbra, Portugal
2014/06/16 - Current Pedro M. P. Fernandes, Bruno L. Victor, Cândida G. Silva, Rui M.M. Brito (2014) Molecular docking and molecular dynamics studies of the interaction of ThT with ß2-microglobulin
Congress
 Coimbra Chemistry Centre Day
Universidade de Coimbra, Portugal
2009/11/23 - Current Victor BL, Baptista AM, Soares CM, "Interaction studies of the fusion peptide of Hemagglutinin H3 with DMPC and DMPG membrane bilayers – a molecular modelling approach"
Congress
 Expanding the frontiers of molecular dynamics simulations in biology
2008/09/22 - Current Victor, BL, Baptista AM, Soares, CM "Dioxygen and Nitric Oxide affinity and pathways to the catalytic site of Rubreoxin:Oxygen Oxidoreductase from Desulfovibrio gigas"
Congress
 ECCB08 – European Conference on Computational Biology
2008 - Current Victor, BL, Baptista AM, Soares, CM "Dioxygen and Nitric Oxide affinity and pathways to the catalytic site of Rubredoxin:Oxygen Oxidoreductase from Desulfovibrio gigas"
Congress
 First Portuguese-Spanish-British Biophysical Congress
2007/05/16 - Current Victor, BL, Baptista AM, Soares, CM “Rubredoxin:Oxygen OxidoReductase from Desulfovibrio gigas: Molecular Dynamics Diffusion Simulations with Dioxygen and Nitric Oxide”. Poster presentation FEBS WORKSHOP ON Trends in Transient Interactions between Biological Macromolecules
2006/09/17 - Current Victor, BL, Baptista AM, Soares, CM “Study of proton channels found in the Quinol Oxidase aa3 from Acidianus ambivalens using molecular modeling methodologies”. Poster presentation MGMS conference - Quantum Pharmacology - 30 years on, A Special Conference in Honour of Prof. W. Graham Richards
2005/09/11 - Current Teixeira, V. H., Cunha, C. A., Machuqueiro, M., Oliveira, A. S. F., Victor, B. L., Soares, C. M., Baptista, A. M. (2005) "On the use of different dielectric constants for computing individual and pairwise terms in Poisson-Boltzmann studies of protein ionization equilibrium". Poster presentation
Congress
 MGMS 2005: Biomolecular Simulations - From Prediction to Practice
2005/08/27 - Current Victor, BL, Baptista AM, Soares, CM “A new theoretical approach to study proton channels in the Quinol Oxidase aa3 from Acidianus ambivalens”, Poster presentation
Congress
 15th IUPAB and 5th EBSA Biophysics Congress
2004/12/02 - Current Victor, BL, Baptista AM, Soares, CM (2004) “Theoretical study of proton channels in the Quinol Oxidase aa3 from Acidianus ambivalens”, Poster Presentation
Congress
 XIV Congresso Nacional de Bioquímica
2004/08/21 - Current Victor, BL, Baptista AM, Soares, CM “Study of proton channels in the quinol oxidase (aa3) from Acidianus ambivalens using theoretical methodologies”. Poster presentation
Congress
 13th European Bioenergetics Conference – EBEC
2003/08/26 - Current Victor, BL, Vicente, JB, Rodrigues, R, Oliveira, S, Rodrigues-Pousada, C, Frazão, C, Gomes, CM, Teixeira, M, Soares, CM “Rubredoxin and rubredoxin:oxygen oxidoreductase: two interacting proteins in a soluble electron transfer chain”. Poster presentation
Congress
 56th Harden Conference “Biological electron and proton transfer”
2002/12 - Current Victor, BL, Vicente, J, Rodrigues, R, Oliveira, S, Rodrigues-Pousada, C, Frazão, C, Gomes, CM, Teixeira, M, Soares, CM "Modelling the interactions and the electron transfer of rubredoxin and rubredoxin:oxgen oxidoreductase". Poster presentation
Congress
 XIII Congresso Nacional de Bioquímica
2002/09 - Current Victor, BL Vicente, JB, Rodrigues, R, Oliveira, S, Rodrigues-Pousada, C, Frazão, C, Gomes, CM, Teixeira, M, Soares, CM (2002) "Interaction studies between rubredoxin (Rd) and rubredoxin-oxygen oxido reductase (ROO)". Poster presentation
Congress
 ESF conference in Computational biophysics: integrating theoretical physics and biology

Association member

Society Organization name Role
2009/01/01 - 2012/10/30 Portuguese Biochemical Society Member of the Directive Board of the
2003/01/01 - 2008/12/31 Portuguese Biophysical Society Second Secretary of the General Assembly

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/02/01 - 2021/06/30 Biochemical Simulation Bioquímica (Licenciatura) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2004/09 - 2012/06 Theoretical and practical teaching classes in Molecular Visualization, Molecular Docking, Protein Homology Modelling and Molecular Mechanics integrated in the PhD Program of ITQB-UNL and Instituto Gulbenkian da Ciência (Doutoramento) Instituto Gulbenkian de Ciência, Portugal
2008/09 - 2009/02 Biochemistry classes for the Biochemical engineering diploma course at Lusofona University Biochemical engineering (Licenciatura) Universidade Lusófona Associação para a Investigação e Desenvolvimento em Cognição e Computação Centrado nas Pessoas, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019/01/01 - Current Pharmaceuticals (1424-8247) MDPI AG
2017/01 - Current Bioengeneering
2017/01 - Current Scientia Pharmaceutica (2218-0532) MDPI AG
2017/01 - Current PLoS ONE (1932-6203) Public Library of Science
2016/01/01 - Current BioMed Research International (2314-6141) Hindawi Limited
2016/01/01 - Current Journal of Molecular Structure (0022-2860) Elsevier
2016/01 - Current Molecules (1420-3049) MDPI AG
2015/01/01 - Current Membranes (2077-0375) MDPI AG
2013/01/01 - Current International Journal of Computational and Theoretical Chemistry (2376-7286) Science Publishing Group
2013/01/01 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2013/01/01 - Current JBIC Journal of Biological Inorganic Chemistry (1432-1327) Springer-Verlag