Identification
Personal identification
- Full name
- Carina Santos Henriques
Citation names
- Henriques, Carina
Author identifiers
- Ciência ID
- 5B12-3335-A348
- ORCID iD
- 0000-0001-9974-754X
Email addresses
- uc44868@uc.pt (Professional)
- cshenriques@cnc.uc.pt (Professional)
- chenriques4657@gmail.com (Personal)
Telephones
- Telephone
-
- 239855089 (Professional)
Addresses
- Rua Larga, Faculty of Medicine, 3004-504, Coimbra, Coimbra, Portugal (Professional)
Websites
- www.uc.pt/ucbusiness/pts/viravector (Professional)
- www.cibb.uc.pt (Professional)
Knowledge fields
- Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Natural sciences - Biological Sciences - Biology
- Natural sciences - Biological Sciences - Cell Biology
- Natural sciences - Biological Sciences - Molecular Biology
- Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
- Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
- Medical and Health Sciences - Basic Medicine - Human Genetics
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
Portuguese (Mother tongue) | |||||
English | Upper intermediate (B2) | Upper intermediate (B2) | Upper intermediate (B2) | Advanced (C1) | Upper intermediate (B2) |
Education
Degree | Classification | |
---|---|---|
2021/01/01 - 2025/01/01
Ongoing
|
Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Towards Clinical Translation of an AAV-based silencing strategy for therapy of Machado-Joseph disease" (THESIS/DISSERTATION)
|
|
2023/03/28 - 2023/03/31
Concluded
|
ESGCT 6th Annual Spring School (Outros)
European Society of Gene & Cell Therapy, Belgium
|
|
2022/11/08 - 2022/12/06
Concluded
|
BioSTART 1st edition (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2021/05/17 - 2021/05/28
Concluded
|
Principles and Practice in Drug Development (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra, Portugal
|
|
2020/11 - 2021/05
Concluded
|
IV Modular Structure training in Laboratory Animal Science (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2021/04/19 - 2021/04/23
Concluded
|
Advanced Therapies (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra, Portugal
|
|
2021/02/01 - 2021/02/05
Concluded
|
High-Throughput Screening for Target and Drug Discovery (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra, Portugal
|
|
2016/09/13 - 2018/11/09
Concluded
|
Biologia Molecular e Genética (Mestrado integrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Modified-exosomes as gene delivery vectors for the treatment of Machado-Joseph disease" (THESIS/DISSERTATION)
|
18 |
2018
Concluded
|
Gestão de Resíduos Hospitalares Perigosos - Triagem e Acondicionamento (Outros)
ambiwaste, Portugal
|
|
2013/09 - 2016/06/28
Concluded
|
Ciências Biomédicas (Licenciatura)
Major in Menor em Biomedicina Molecular
Universidade de Aveiro, Portugal
|
15 |
2016
Concluded
|
First Certificate in English (Outros)
Cambridge English Language Assessment, Russia
|
B2 |
2016
Concluded
|
Certificado de Formação Profissional (Outros)
Associação Formar para Salvar, Portugal
|
18 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2022/01 - Current | Researcher (Research) | Universidade de Coimbra, Portugal |
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal | ||
2019/12/30 - 2021/12/31 | Researcher (Research) | Universidade de Coimbra, Portugal |
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal | ||
2019/02/25 - 2019/12/24 | Researcher (Research) | Universidade de Coimbra, Portugal |
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal (...) |
||
2017/09/01 - 2018/10/09 | Research Trainee (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal | ||
2016/09 - 2017/01 | Research Trainee (Research) | Universidade de Lisboa, Portugal |
Universidade de Lisboa Faculdade de Farmácia, Portugal | ||
2016/07/01 - 2016/07/15 | Research Trainee (Research) | Universidade de Aveiro, Portugal |
Universidade de Aveiro Instituto de Biomedicina, Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2018/11/12 - 2019/02/27 | Voluntary Researcher in continuation of MSc Thesis project | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2019/02/25 - 2022/03 | ViraVector - Viral Vector for Gene Transfer Core facility
CENTRO-01-0145-FEDER-022095
Research Fellow
Universidade de Coimbra - ViraVector, Portugal
|
CENTRO 2020
Ongoing
|
2019/12/30 - 2021/12/31 | BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Research Fellow
|
CENTRO 2020 |
2020/06 - 2020/11 | Expedited validation and large-scale manufacture of a blowing device for collection with inactivation of samples for detection
of SARS-CoV-2
269_596884125
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Universidade de Coimbra - ViraVector, Portugal |
Fundação para a Ciência e a Tecnologia |
2018/09 - 2019/06 | Exosomes as gene delivery vectors for the treatment of Machado-Joseph disease/Spinocerebellar ataxia type 3
21163
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
AFM-Téléthon
Concluded
|
Contract
Designation | Funders | |
---|---|---|
2020/06 - 2022/12 | mirSilencing
NA
Researcher
PTC Therapeutics Inc, United States
|
PTC Therapeutics Inc
Concluded
|
2019/08 - 2020/05 | Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
NA
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Wave Life Sciences
Concluded
|
2019/11 - 2020/01 | A Therapeutic Strategy in Machado-Joseph Disease
CPD0020A01
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Blade Therapeutics, Inc
Ongoing
|
2019/02 - 2019/09 | Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA
NA
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
uniQure NV
Concluded
|
Other
Designation | Funders | |
---|---|---|
2020/04 - 2020/06 | Covid-19 Lab @ CNC / ViraVector
NA
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra - ViraVector, Portugal |
|
2020/03/26 - 2020/05 | COVID-19 UC Lab
NA
Other
Universidade de Coimbra Laboratório de Análises Clínicas, Portugal
|
Ongoing
|
Outputs
Publications
Conference poster |
|
Journal article |
|
Newspaper article |
|
Thesis / Dissertation |
|
Artistic / Performance
Theatre play |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2024/02 | Extracellular vesicles delivery of CRISPR-Cas9 RNPs for therapeutic gene editing in Spinocerebellar Ataxia Type 3 | 54ª Reunião da Sociedade Portuguesa de Farmacologia, 42.ª Reunião de Farmacologia Clínica e 23ª Reunião de Toxicologia
(Lisboa, Portugal)
|
2024/02 | Hacking biology: optimizing AAV-based gene delivery for enhanced brain regio-specific targeting | 54ª Reunião da Sociedade Portuguesa de Farmacologia, 42.ª Reunião de Farmacologia Clínica e 23ª Reunião de Toxicologia
(Lisboa, Portugal)
|
2024/02 | Generation of lentiviral-based mouse models of spinocerebellar ataxias: where to target? | 42.ª Reunião de Farmacologia Clínica e 23ª Reunião de Toxicologia, Lisboa, Portugal, 7-9 February 2024
(Lisboa, Portugal)
|
2024/02 | Targeted silencing via AAV9 polycistronic microRNA therapy rescues SCA3 molecular, neuropathological and motor deficits | 54ª Reunião da Sociedade Portuguesa de Farmacologia, 42.ª Reunião de Farmacologia Clínica e 23ª Reunião de Toxicologia
(Lisboa, Portugal)
|
2023/11 | Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph disease | PharmaDay
(Coimbra, Portugal)
|
2023/11 | Polycistronic artificial microRNAs delivery by AAV9 alleviate Spinocerebellar ataxia type 3(SCA3) | PharmaDay
(Coimbra, Portugal)
|
2023/11 | Targeting sirtuin-1 with CRISPR activation: a new therapeutic approach for SCA3 | PharmaDay
(Coimbra, Portugal)
|
2023/06 | Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Spinocerebellar Ataxia Type 3/Machado-Joseph Disease | CAG Triplet Repeat Disorders GRC
(Vermont, United States)
|
2023/05 | Isolation of Natural and Biologically Active EV-AAVs for Brain Gene | American Society of Gene Therapy (ASGCT) 26th Annual
(Los Angeles, United States)
|
2022/02 | Upregulation of autophagy as a therapeutic strategy for SCA2 disease | 52ª Reunião da Sociedade Portuguesa de Farmacologia, 40.ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia
(Porto, Portugal)
|
2022/02 | Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization strategies | 52ª Reunião da Sociedade Portuguesa de Farmacologia, 40.ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia
(Porto, Portugal)
|
2021/02/19 | Development Of Single-Step Affinity Chromatography Protocols For The Purification Of Adeno-Associated Viral Vectors | 20ª Reunião de Toxicologia. A Sociedade Portuguesa de Farmacologia
(Lisboa, Portugal)
|
2021/02/18 | MixcapAAV1/2 Vector: A Novel Gene Delivery System Distribution, Spreading And Tropism Analysis In Normal Mice | 20ª Reunião de Toxicologia. A Sociedade Portuguesa de Farmacologia
(Lisboa, Portugal)
|
2021/02/18 | Brain MicroRNAs In Plasma-Derived Extracellular Vesicles As Potential Biomarkers For Machado-Joseph Disease | 20ª Reunião de Toxicologia. A Sociedade Portuguesa de Farmacologia
(Lisboa, Portugal)
|
2021/02/18 | Allele-Specific Silencing Of Machado-Joseph Disease Using Antisense Oligonucleotide Therapeutics | 20ª Reunião de Toxicologia. A Sociedade Portuguesa de Farmacologia
(Lisboa, Portugal)
|
2019/11/15 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders | 1st Annual Meeting in Pharmaceutical Sciences
(Coimbra, Portugal)
|
2019/11 | miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls | 23rd Annual Meeting, Portuguese Society of Human Genetics
(Coimbra, Portugal)
|
2019/11 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases (Flash poster presentation) | 5th GEIVEX Symposium |
2019/02/06 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases | XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
(Porto, Portugal)
|
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2018/11/19 - 2018/11/30 | Divulgação do trabalho desenvolvido no CNC ao público através de conversas e atividades informais nos autocarros da SMTUC
pela cidade de Coimbra, no contexto da Semana da Ciência e da Tecnologia 2018
Other
|
Brain Buskers nos autocarros
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Association member
Society Organization name | Role | |
---|---|---|
2019/09 - Current | GEIVEX (Grupo Español de Investigación e Innovación en Vesículas Extracelulares) | |
2017/04 - 2017/08 | Board of European Students of Technology (BEST) Lisbon | Corporate Relations |
2017/03 - 2017/06 | Re-food Nossa Senhora de Fátima, Lisboa | Voluntary |
2016/01 - 2017/01 | Núcleo de Ciências Biomédicas - Associação Académica da Universidade de Aveiro (NECiB-AAUAv) | Marketing and Communication Department |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2014/09 - 2016/06 | Programa de Tutoria / PT-UA | Ana Claudio, Margarida Vale, Rita Soares, Ivana Martins, Jéssica Santos, Maria Pinto,Tânia Gonçalves |
2015/09 - 2016/01 | Erasmus Student Network (ESN) Aveiro | Szymon Fraszczyk |
Distinctions
Award
2023 | Meritorious Abstract Travel Award
American Society of Gene & Cell Therapy, United States
|
2019 | Winner of 3rd BEB/BluePharma award
Bluepharma, Portugal
|