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JOSÉ CARLOS BARREIRO MATEUS. Completed the Doutoramento in Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (BiotechHealth) in 2022 by Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Mestrado in Biomedicina Molecular in 2015 by Universidade de Aveiro and Licenciatura in Ciências Biomédicas in 2013 by Universidade de Aveiro. Is Contracted Researcher in Universidade do Porto Instituto de Investigação e Inovação em Saúde. Published 10 articles in journals. Organized 2 event(s). Participated in 2 event(s). Supervised 1 MSc dissertation(s). Has received 8 awards and/or honors. Participates and/or participated as PhD Student Fellow in 3 project(s), Post-doc in 1 project(s), Post-doc Fellow in 3 project(s) and Principal investigator in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences and Engineering and Technology with emphasis on Medical Engineering. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Neuroengineering; Medical Implants; Neurostimulator; Low-power; Nanotechnology; Axonal Cytoskeleton; Actin; Computational and Biophysical Modeling; Quantitative Imaging; Neurosciences; Infection and Immunity; Cancer; Bioengineering; Health; Biomedicine; Bioengeneering; Biological Sciences; Brain-on-a-chip; neurodevelopment; microelectrode array (MEA); induced pluripotent stem cells (iPSC); .
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Identification

Personal identification

Full name
JOSÉ CARLOS BARREIRO MATEUS

Citation names

  • MATEUS, JOSÉ C

Author identifiers

Ciência ID
5B16-2EF0-5DAD
ORCID iD
0000-0001-8058-5093
Google Scholar ID
https://scholar.google.com/citations?user=j-vUoa4AAAAJ&hl=pt-PT
Scopus Author Id
57205176655

Email addresses

  • jose.mateus@i3s.up.pt (Professional)

Addresses

  • i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2017 - 2022
Concluded
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (BiotechHealth) (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Novel insights into axonal physiology through the development and use of new microelectrode array technologies" (THESIS/DISSERTATION)
2013 - 2015
Concluded
 Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
"Optimization of a multielectrode array (MEA)-based approach to study the impact of Aß on the SH-SY5Y cell line" (THESIS/DISSERTATION)
2010 - 2013
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade de Aveiro, Portugal
"n/a" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2024/02 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02 - 2024/01 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2022 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/09 - 2020/12 Visiting Researcher (Research) ETH Zürich Foundation, Switzerland
ETH Zürich Foundation, Switzerland
2019/09 - 2019/12 Visiting Researcher (Research) ETH Zürich Foundation, Switzerland
ETH Zürich Foundation, Switzerland
2014/04 - 2014/06 Research Trainee (Research) Universidade de Aveiro, Portugal
Universidade de Aveiro Departamento de Biologia, Portugal

Others

Category
Host institution 		Employer
2017 - 2022 PhD Student Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/01 - 2015/12 MSc student Universidade de Aveiro Instituto de Biomedicina, Portugal
Projects

Grant

Designation Funders
2023 - Current Neuromorphic devices for adaptive real-time neuromodulation in brain electrical stimulation therapies
HR22-00189
Post-doc Fellow
"la Caixa" Foundation
Ongoing
2023 - Current smartDBS - Improving Deep Brain Stimulation in Parkinson’ s Disease with Personalized Electrophysiological Biomarkers and Data-Driven Stimulation
Prémio Mantero Belard, MB-12-22
Post-doc Fellow
Santa Casa da Misericórdia de Lisboa
Ongoing
2022 - Current MNemonicS: Storing and recalling biological Memories with Neuromorphic Electronics
PTDC/NAN-MAT/4093/2021
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2025/01/02 - 2026/07/01 Establishing humanized Brain-on-a-Chip devices for the study of Activity-dependent neuronal Development
2023.11280.PEX
10.54499/2023.11280.PEX
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2023 Mind The Gap: decoding and bridging somatosensory information in the spinal cord
PTDC/EMD-EMD/31540/2017
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 ACTinRING: Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology.
PTDC/MED-NEU/28623/2017
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 NIMAS: New Active Medical Implants
PTDC/EEI-EEE/32348/2017
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/08 - 2030/07 Unraveling the mechanisms of neuronal activity-dependent development and disorder with humanized brain-on-a-chip devices
2023.08291.CEECIND
Post-doc
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/06/30 Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology.
PTDC/MED-NEU/28623/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/05/01 - 2021/12/18 New Active Medical Implants
PTDC/EEI-EEE/32348/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. José C Mateus; Mónica Cerquido; Cátia D F Lopes; Diana Leitão; Susana Cardoso; João Ventura; Paulo Aguiar. "A novel 3D-microstructured multielectrode array configuration for high-yield and high-fidelity electrophysiological recordings". 2018.
    10.3389/conf.fncel.2018.38.00028
Conference poster
  1. José C Mateus; Cátia DF Lopes; Miguel Aroso; Ana R Costa; Ana Gerós; João Meneses; Paula Faria; et al. "Spontaneous bidirectional signal conduction along axons in vitro". Paper presented in FENS Regional Meeting 2023, 2023.
  2. Silva, SC; Castro, Domingos; MATEUS, JOSÉ C; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "A Tripartite Microfluidic Device with Integrated Microelectrodes to Study the Neuron-Astrocyte Crosstalk". Paper presented in VII Symposium of the Portuguese Glial Network, 2023.
  3. José C Mateus; Sean Weaver; Dirk van Swaay; Aline F Renz; Julian Hengsteler; Paulo Aguiar; János Vörös. "Controlled patterning of synapse formation in vitro". Paper presented in 8th European Synapse Meeting, 2022.
  4. Silva, SC; Castro, Domingos; MATEUS, JOSÉ C; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "Electrical Stimulation of Astrocytes and its Impact on Astrocytic Calcium Signaling". Paper presented in VI Symposium of the Portuguese Glia Network, 2022.
  5. José C Mateus; Cátia DF Lopes; Miguel Aroso; Ana R Costa; Ana Gerós; João Meneses; Paula Faria; et al. "Spontaneous bidirectional signal conduction along axons in vitro". Paper presented in MEA Meeting 2022, Tübingen, Germany, 2022.
  6. José C Mateus; Cátia DF Lopes; Miguel Aroso; Ana R Costa; Ana Gerós; João Meneses; Paula Faria; et al. "Neuronal cultures show bidirectional axonal conduction with antidromic action potentials depolarizing the soma". Paper presented in Axons 2021: Structure and function, 2021.
    10.1101/2021.03.07.434278
  7. José C Mateus; Cátia D F Lopes; Estrela Neto; António Pereira; Monica M Sousa; Meriem Lamghari; Paulo Aguiar. "Bidirectional and asymmetrical signal conduction along axons: combining in vitro with in silico experiments". Paper presented in FENS Virtual Forum 2020, 2020.
  8. Sean Weaver; José C Mateus; Paulo Aguiar; Janos Voros. "Towards controllable synaptomes in vitro". Paper presented in FENS Virtual Forum 2020, 2020.
  9. Sophie Girardin; José C Mateus; Sean Weaver; Stephan Ihle; Csaba Forró; Janos Voros. "iPSC-derived neurons can be used to build in vitro neuronal circuits with defined connectivity". Paper presented in FENS Virtual Forum 2020, 2020.
  10. José C Mateus; Cátia D F Lopes; Estrela Neto; António Pereira; Monica M Sousa; Meriem Lamghari; Paulo Aguiar. "Bidirectional signal conduction along axons in vitro". Paper presented in NeuroFluidics, Montpellier, France, 2019.
  11. José C Mateus; Cátia D F Lopes; Mónica Cerquido; Luís Leitão; Diana Leitão; Susana Cardoso; João Ventura; Paulo Aguiar. "A new 3D-structured microelectrode array for enhanced in vitro electrophysiology". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, Portugal, 2019.
  12. José C Mateus; Luís Leitão; João Ventura; Paulo Aguiar. "A DIY system for in vitro multielectrode recording". Paper presented in XV Meeting of the Portuguese Society for Neurosciences, Braga, Portugal, 2017.
Journal article
  1. José C Mateus; Pedro Melo; Miguel Aroso; Benoît Charlot; Paulo Aguiar. "Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits". Biofabrication (2025): https://doi.org/10.1088/1758-5090/adb2e5.
    10.1088/1758-5090/adb2e5
  2. José C Mateus; Monica M Sousa; Juan Burrone; Paulo Aguiar. "Beyond a Transmission Cable—New Technologies to Reveal the Richness in Axonal Electrophysiology". The Journal of Neuroscience (2024): https://doi.org/10.1523/JNEUROSCI.1446-23.2023.
    10.1523/JNEUROSCI.1446-23.2023
  3. Estrela Neto; Luís Leitão; José C. Mateus; Daniela M Sousa; Cecília J Alves; Miguel Aroso; Ana C Monteiro; et al. "Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling". Cell & Bioscience 12 1 (2022): http://dx.doi.org/10.1186/s13578-022-00864-w.
    10.1186/s13578-022-00864-w
  4. José C Mateus; Sean Weaver; Dirk van Swaay; Aline F Renz; Julian Hengsteler; Paulo Aguiar; János Vörös. "Nanoscale Patterning of In Vitro Neuronal Circuits". ACS Nano 16 4 (2022): 5731-5742. https://doi.org/10.1021/acsnano.1c10750.
    10.1021/acsnano.1c10750
  5. Sophie Girardin; Blandine Clément; Stephan J Ihle; Sean Weaver; Jana B Petr; José C Mateus; Jens Duru; et al. "Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings". Lab on a Chip (2022): http://dx.doi.org/10.1039/d1lc01110c.
    10.1039/d1lc01110c
  6. José C Mateus; Cátia DF Lopes; Miguel Aroso; Ana R Costa; Ana Gerós; João Meneses; Paula Faria; et al. "Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures". Journal of Neural Engineering (2021): https://doi.org/10.1088/1741-2552/ac41db.
    10.1088/1741-2552/ac41db
  7. Ana Rita Costa; Sara C Sousa; Rita Pinto-Costa; José C Mateus; Cátia DF Lopes; Ana Catarina Costa; David Rosa; et al. "The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction". eLife (2020): https://doi.org/10.7554/eLife.55471.
    10.7554/eLife.55471
  8. José C Mateus; Cátia D F Lopes; Mónica Cerquido; Luís Leitão; Diana Leitão; Susana Cardoso; João Ventura; Paulo Aguiar. "Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis". Journal of Neural Engineering (2019): https://doi.org/10.1088/1741-2552/ab0b86.
    10.1088/1741-2552/ab0b86
  9. Kristine Heiney; José C Mateus; Cátia D F Lopes; Estrela Neto; Meriem Lamghari; Paulo Aguiar. "µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-019-42148-3.
    10.1038/s41598-019-42148-3
  10. Cátia D F Lopes; José C Mateus; Paulo Aguiar. "Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation.". Journal of visualized experiments : JoVE (2018): https://doi.org/10.3791/58878.
    10.3791/58878
Preprint
  1. JC Mateus; P Melo; M Aroso; B Charlot; P Aguiar. "Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits". 2024. https://doi.org/10.1101/2024.07.09.602729.
    10.1101/2024.07.09.602729
  2. João Serra; José C. Mateus; Susana Cardoso; João Ventura; Paulo Aguiar; Diana C. Leitao. "Stress-actuated Flexible Microelectrode Arrays for Activity Recording in 3D Neuronal Cultures". 2024. https://doi.org/10.1101/2024.12.12.628189.
    10.1101/2024.12.12.628189
  3. José C Mateus; Cátia D F Lopes; Miguel Aroso; Ana Rita Costa; Ana Gerós; António Pereira; João Meneses; et al. "Neuronal cultures show bidirectional axonal conduction with antidromic action potentials depolarizing the soma". 2021. https://www.biorxiv.org/content/10.1101/2021.03.07.434278v3.full.
    10.1101/2021.03.07.434278
  4. José C Mateus; Sean Weaver; Dirk van Swaay; Aline F Renz; Julian Hengsteler; Paulo Aguiar; János Vörös. "Nanoscale patterning of in vitro neuronal circuits". 2021. https://www.biorxiv.org/content/10.1101/2021.12.16.472887v2.
    10.1101/2021.12.16.472887
  5. "Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings". 2021. http://dx.doi.org/10.1101/2021.12.10.472063.
    10.1101/2021.12.10.472063
  6. Estrela Neto; Luís Leitão; José C Mateus; Daniela M. Sousa; Francisco Conceição; Cecília J. Alves; Richard O.C. Oreffo; et al. "Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptors". 2020. https://www.biorxiv.org/content/10.1101/259218v2.
    10.1101/259218

Other

Dataset
  1. MATEUS, JOSÉ C; Aguiar, Paulo. Sample raw data for publication "Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures".
    10.5281/zenodo.5745979
  2. MATEUS, JOSÉ C; Aguiar, Paulo. Data for publication "Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits". https://zenodo.org/records/14525182. 2024.
    10.5281/zenodo.14525181
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/02 Neuronal cultures show bidirectional axonal conduction with antidromic action potentials effectively depolarizing the soma XVIII Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (SPN) (Coimbra, Portugal)
2021/11/10 Novel insights into axonal physiology through the development and use of new microelectrode array technologies Mind your Neuro
Scientific Junior Value (Portugal)
2021/09/04 Novel insights into axonal physiology through the development and use of new microelectrode array technologies Biomedical Engineering Summit
Associação Nacional de Estudantes de Engenharia Biomédica (ANEEB) (Lisbon, Portugal)
2019/07/15 A new 3D-structured microelectrode array for enhanced in vitro electrophysiology 1st Minho Meeting on Spinal Cord Injury and 1st International Meeting of the Portuguese Network for SCI Research
(Braga, Portugal)
2017/11/08 Establishing in vitro models for multielectrode array (MEA) studies i3S Annual Meeting
(Portugal)
2017/06/20 A DIY system for in vitro multielectrode recording Advanced Summer School: The Research/ Clinic Interface At The Spine
i3S (Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - 2024 Caracterização da comunicação eletrofisiológica entre populações neuronais com arquitetura definida
Supervisor of Pedro Melo
Universidade do Porto Faculdade de Engenharia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - Current 4th Workshop on Neuroengineering: brain-on-a-chip platforms (2024/04)
Workshop (Co-organisor)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2018 V BiotechHealth Annual Symposium (2018 - 2018) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/04/09 - 2019/04/10 Responsible for a hands-on practical session on “Principles of multielectrode arrays (MEAs) electrophysiology” in a workshop on the field of Neurosciences/Neuroengineering.
Workshop
 Workshop on Neuroengineering | 3rd ed Decoding Neural Information
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/04/09 - 2018/04/10 Responsible for a hands-on practical session on “Principles of multielectrode arrays (MEAs) electrophysiology” in a workshop on the field of Neurosciences/Neuroengineering.
Workshop
 2nd Workshop on Neuroengineering: Electroceuticals
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current Lab on a Chip The Royal Society of Chemistry
2023 - Current Journal of Neural Engineering IOP Publishing
2023 - Current Biofabrication IOP Publishing
2023 - Current Journal of Micromechanics and Microengineering IOP Publishing
2022 - Current IEEE Access IEEE

Association member

Society Organization name Role
2018 - Current Sociedade Portuguesa de Neurociências

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Frontiers in Neuroscience (1662-453X) Frontiers

Mentoring / Tutoring

Topic Student name
2025 - Current Ricardo Pinto
2024/02 - 2024/06 Marcos Oriol Pagonabarraga
2023/09 - 2024/02 Babette Furchtbar
2023/02 - 2023/09 Ana Filipa Sousa
Distinctions

Award

2024 Junior Researcher (6th edition of CEEC Individual Call)
Fundação para a Ciência e a Tecnologia, Portugal
2023 Trusted Reviewer Status
IOP Publishing Ltd, United Kingdom
2022 Young Researcher Scholarship
8th European Synapse Meeting, Portugal
2022 Prémio Mantero Belard
Santa Casa da Misericórdia de Lisboa, Portugal
2020 FENS-IBRO/PERC Travel Grant
FENS - Federation of European Neuroscience Societies, Belgium
2017 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2023 FENS Regional Meeting 2023 Neuroscience Photography Contest
FENS - Federation of European Neuroscience Societies, Belgium
2022 Photo Contest - 2023 ibidi Calendar
ibidi GmbH, Germany