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After a 4 years degree in Biochemistry Frederico Silva got his PhD from the University of Porto in 2006, studying the structure and intracellular targeting of proteins, using a multidisciplinary approach covering diverse fields such as Yeast cell biology, biochemistry and protein crystallography. Back in 2005 he was involved in the set up of a Scientific Platform, that he heads, dedicated to the production and purification of recombinant proteins, that later broadened its scope developing work in Biochemistry and Molecular Biophysics. His lab has extensive experience in a broad range of technologies such as molecular cloning, construct design, preparative and analytical (HPLC) chromatography, ultracentrifugation, fluorimetry, circular dichoism, surface plasmon ressonance and isothermal titration calorimetry. He has been actively involved in the development of pan European communities in the fields of protein production and molecular biophysics. Frederico coordinates several postgraduate activities such as an EMBO practical course running every other year focusing in the study of molecular interactions and a yearly practical course on protein expression, purification and characterization of the MCBiology PhD program. He coordinates the Training and Human capacity Development section of the Association of Resources for Biophysical Research in Europe.
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Identification

Personal identification

Full name
Frederico Silva

Citation names

  • Frederico Ferreira-da-Silva

Author identifiers

Ciência ID
5B17-0E0A-AAE3
ORCID iD
0000-0002-8890-4228
Google Scholar ID
Q-GWZPcAAAAJ
Researcher Id
K-3820-2013
Scopus Author Id
24778164700

Email addresses

  • ffsilva@i3s.up.pt (Professional)

Telephones

Telephone
  • 220408800 (Professional)

Addresses

  • i3S & IBMC. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
French Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2006
Concluded
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal
"GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ISOFORM 1 FROM KLUYVEROMYCES MARXIANUS: STRUCTURE AND FUNCTIONAL ANALYSIS" (THESIS/DISSERTATION)
 Passed (unanimity)
1997
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciencias, Portugal

Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal
"“Expression of the GAP1 gene from K. marxianus in E. coli for crystalography”" (THESIS/DISSERTATION)
 15 out of 20
Affiliation

Science

Category
Host institution 		Employer
1997/10/01 - 2005/02/28 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2013/09/01 - Current Visiting Professor (University Teacher) Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal
1999/10/01 - 2005/09/30 Assistant (University Teacher) Cooperativa de Ensino Superior Politecnico e Universitario, Portugal

Other Careers

Category
Host institution 		Employer
2005/03/01 - Current Técnico Superior (Técnico Superior) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Others

Category
Host institution 		Employer
2015/11/01 - Current Head of Scientific Platform Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2005/03/01 - Current Head of Protein Production and Purification Unit Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
1999/10 - 2004/09 GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ISOFORM 1 FROM KLUYVEROMYCES MARXIANUS: STRUCTURE AND FUNCTIONAL ANALYSIS
PRAXIS XXI/BD/19777/99
PhD Student Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal
Fundação para Ciência e Tecnologia
Concluded
1997/10 - 1999/09 Studies on the intracellular traffic of p37 in S. cerevisiae
PRAXIS XXI/BIC/4695/96
Scientific Initiation Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para Ciência e Tecnologia
Concluded

Contract

Designation Funders
2020/09/01 - Current PhasAGE: Excellence Hub on Phase Transitions in Aging and Age-Related Disorders
grant agreement No 952334
Researcher
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2021/01/01 - 2025/12/31 Instituto de Investigação e Inovação em Saúde
LA/P/0070/2020
10.54499/LA/P/0070/2020
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/15 - 2023/12/31 IronIC | Infection and iron homeostasis: a new perspective for an old question
EXPL/BIA-BQM/1170/2021
Researcher
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
 Fundação para Ciência e Tecnologia
Concluded
2019/01 - 2021/12 Targeting diffusible oligomers of alpha-synuclein and ataxin-3: a drug repurposing opportunity for the treatment of neurodegenerative diseases
PTDC/MED-FAR/31323/2017
Researcher
Fundação para a Ciência e a Tecnologia
2016/04 - 2020/04 Between Atom and Cell: Integrating Molecular Biophysics Approaches for Biology and Healthcare (MOBIEU)
CA15126
Researcher
European Cooperation in Science and Technology
Ongoing
2019/01 - 2019/12 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
Researcher
Fundação para a Ciência e a Tecnologia
2016/05 - 2019/04 Porto Neurosciences and Neurologic Disease Research Initiative at I3S
Norte-01-0145-FEDER-000008
Researcher
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2013/07 - 2015/06 Characterization and application of the novel molinate hydrolase (MolA) in bioremediation processes
Provided by PTCRIS: 130494
130494
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/04 - 2015/03 MatriCard - Dissection and Reconstruction of the Extracellular Matrix: A Cardiac Regenerative Niche
118297
Provided by PTCRIS: 118297
Researcher
Instituto Nacional de Engenharia Biomedica, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06 - 2013/11 Survey of the Leishmania thiol system for the development of new anti-parasitic formulas
Provided by PTCRIS: 100910
100910
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/06 - 2013/11 A peptide aptamer-based approach to neurodegenerative disorders
Provided by PTCRIS: 100059
100059
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/08 - 2013/03 Development of new control measures against Leishmaniasis based on the parasite’s mitochondrial peroxiredoxin system
P-105335
 Fundação Calouste Gulbenkian
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/12 - 2012/11 Epigenetics of antigenic variation: defining new drug targets that make African trypanosomes more susceptible to the host immune response
P-105333
Researcher
Fundação Calouste Gulbenkian
2010/04 - 2012/01 Biochemical and biophysical characterization of AIP56, a novel bacterial apoptogenic exotoxin
101111
Provided by PTCRIS: 101111
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2020/11 - 2020/11 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2021
pc20-20
Principal investigator
Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH, Germany
 Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH
Concluded
2018/10/29 - 2018/11/03 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2018
pc18/30
Principal investigator
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH
Ongoing
2016/11 - 2016/11 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2016
pc16/18
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH
Concluded
2014/11 - 2014/11 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2014
pc14/17
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH
Concluded
2012/11 - 2012/11 Biomolecular Interactions Analysis 2012
xxxxxxxxx
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 INSTRUCT
Concluded
Outputs

Publications

Book chapter
  1. Silva, Frederico; Moradas-Ferreira, P.. "Protein Synthesis and post-translational processing". In Biologia Celular e Molecular (Cell and Molecular Biology), edited by Claudio sunkel; Carlos Azevedo. Lisboa, Portugal: LIDEL, 2012.
    Published
  2. Silva, Frederico; Pedro Moradas Ferreira. "Protein Synthesis and post-translational processing". In Biologia Celular e Molecular (Cell and Molecular Biology), edited by Carlos Azevedo. Lisboa, Portugal: LIDEL, 2005.
    Published
Conference paper
  1. Raquel Gonçalves; Maria Molinos; Antunes, Joana C.; Catarina Leite Pereira; Frederico Ferreira-da-Silva; Mário A. Barbosa. "Development of Chitosan-based delivery system to recruit mesenchymal stem cells". Paper presented in TERMIS EU 2011 Annual Meeting, 2011.
  2. Pereira, C.L.; Gonçalves, R.M.; Ferreira-Da-silva, F.; Antunes, J.C.; Molinos, M.; Barbosa, M.A.. "Biosynthesis of poly-¿-glutamic acid and its application in the development of chitosan/poly-¿-glutamic acid nanoparticles for drug delivery". 2011.
    10.1016/j.bbamem.2015.02.001
Conference poster
  1. Fonseca, Óscar; Ramos, Ana; Couto, Carolina A; Silva, André; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "Triggering the shift - serum iron proteins in the crosstalk between iron biology and immune response". Paper presented in European Iron Club Conference, Toulouse, 2024.
  2. Fonseca, Óscar; Ramos, Ana; Couto, Carolina A; Silva, André; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "Serum iron redistribution during mycobacterial infection - exploring the iron-shift". Paper presented in 10th edition of the Molecular and Cell Biology Symposium - "A decade building science", 2024.
  3. Ramos, Ana Sofia; Fonseca, Óscar; Frederico Ferreira-da-Silva; Silva, André; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "The serum ¿iron-shift¿ during mycobacterial infection". Paper presented in SPI' 48 XLVIII Annual meeting of the Portugese Society of Immunology, 2023.
  4. Fonseca, Óscar; Couto, Carolina; Ramos, Ana; Silva, André; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. Corresponding author: Fonseca, Óscar. "The shift in iron metabolism: a new anti-inflammatory strategy?". Paper presented in 1st Symposium on Iron Metabolism and Cancer, 2023.
  5. Ramos, Ana; Fonseca, Óscar; Frederico Ferreira-da-Silva; Silva, André; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. Corresponding author: Ramos, Ana. "SPI' 48 XLVIII Annual meeting of the Portugese Society of Immunology". 2023.
  6. Frederico Ferreira-da-Silva. "Protein production and Biomolecular analysis@ Porto: from knowledge to support". Paper presented in CTLS 2014 Conference (https://ctls-org.eu/), 2014.
  7. Antunes, Joana C.; Catarina Leite Pereira; Maria Molinos; Frederico Ferreira-da-Silva; Mariagemiliana Dessì; Antonio Gloria; Luigi Ambrosio; Raquel M. Gonçalves; Mário A. Barbosa. "Layer-by-layer self-assembly of Chitosan and Poly(gamma-glutamic acid) into polyelectrolyte complexes". Paper presented in 9th World Biomaterials Conference, 2012.
  8. Frederico Ferreira-da-Silva; val. "AIP56, an apoptogenic AB-toxin targeting NF-kB p65". Paper presented in 15th European Workshop on Bacterial Protein Toxins, 2011.
Journal article
  1. Anja Schütz; Frank Bernhard; Nick Berrow; Johannes F. Buyel; Frederico Ferreira-da-Silva; Jurgen Haustraete; Joop van den Heuvel; et al. "A concise guide to choosing suitable gene expression systems for recombinant protein production". STAR Protocols (2023): https://doi.org/10.1016/j.xpro.2023.102572.
    10.1016/j.xpro.2023.102572
  2. Margarida Bastos; Olga Abian; Christopher M. Johnson; Frederico Ferreira-da-Silva; Sonia Vega; Ana Jimenez-Alesanco; David Ortega-Alarcon; Adrian Velazquez-Campoy. "Isothermal titration calorimetry". Nature Reviews Methods Primers (2023): https://doi.org/10.1038/s43586-023-00199-x.
    10.1038/s43586-023-00199-x
  3. "Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity". European Journal of Immunology (2022): http://dx.doi.org/10.1002/eji.202149491.
    10.1002/eji.202149491
  4. Frederico Ferreira-da-Silva. "Grape pectic polysaccharides stabilization of anthocyanins red colour: mechanistic insights". Carbohydrate Polymers (2020): 117432-117432. http://dx.doi.org/10.1016/j.carbpol.2020.117432.
    10.1016/j.carbpol.2020.117432
  5. Frederico Ferreira-da-Silva. "DIBMA nanodiscs keep a-synuclein folded". Biochimica et Biophysica Acta (BBA) - Biomembranes (2020): http://dx.doi.org/10.1016/j.bbamem.2020.183314.
    10.1016/j.bbamem.2020.183314
  6. Frederico Ferreira-da-Silva. "Molecular binding between anthocyanins and pectic polysaccharides – Unveiling the role of pectic polysaccharides structure". Food Hydrocolloids (2020): http://dx.doi.org/10.1016/j.foodhyd.2019.105625.
    10.1016/j.foodhyd.2019.105625
  7. Plácido, A.; Ferreira-Da-Silva, F.; Leite, J.R.S.A.; de-Los-Santos-Álvarez, N.; Delerue-Matos, C.. "A convenient renewable surface plasmon resonance chip for relative quantification of genetically modified soybean in food and feed". PLoS ONE 15 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080083752&partnerID=MN8TOARS.
    10.1371/journal.pone.0229659
  8. Frederico Ferreira-da-Silva. "Interaction between Ellagitannins and Salivary Proline-Rich Proteins". Journal of Agricultural and Food Chemistry (2019): http://dx.doi.org/10.1021/acs.jafc.9b02574.
    10.1021/acs.jafc.9b02574
  9. Barros, D.; Parreira, P.; Furtado, J.; Ferreira-da-Silva, F.; Conde-Sousa, E.; García, A.J.; Martins, M.C.L.; Amaral, I.F.; Pêgo, A.P.. "An affinity-based approach to engineer laminin-presenting cell instructive microenvironments". Biomaterials 192 (2019): 601-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059918479&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2018.10.039
  10. Soares, S.; Santos Silva, M.; García-Estévez, I.; Brandão, E.; Fonseca, F.; Ferreira-da-Silva, F.; Teresa Escribano-Bailón, M.; Mateus, N.; de Freitas, V.. "Effect of malvidin-3-glucoside and epicatechin interaction on their ability to interact with salivary proline-rich proteins". Food Chemistry 276 (2019): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054184252&partnerID=MN8TOARS.
    10.1016/j.foodchem.2018.09.167
  11. Soares, S.; García-Estévez, I.; Ferrer-Galego, R.; Brás, N.F.; Brandão, E.; Silva, M.; Teixeira, N.; et al. "Study of human salivary proline-rich proteins interaction with food tannins". Food Chemistry 243 (2018): 175-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030457914&partnerID=MN8TOARS.
    10.1016/j.jchromb.2014.05.029
  12. Ghaeli, I.; De Moraes, M.A.; Beppu, M.M.; Lewandowska, K.; Sionkowska, A.; Ferreira-Da-Silva, F.; Ferraz, M.P.; Monteiro, F.J.. "Phase behaviour and miscibility studies of collagen/silk fibroin macromolecular system in dilute solutions and solid state". Molecules 22 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85027987604&partnerID=MN8TOARS.
    10.1016/j.actbio.2012.10.029
  13. Monteiro, C.; Fernandes, M.; Pinheiro, M.; Maia, S.; Seabra, C.L.; Ferreira-Da-Silva, F.; Costa, F.; et al. "Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78". Biochimica et Biophysica Acta - Biomembranes 1848 5 (2015): 1139-1146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923289681&partnerID=MN8TOARS.
    10.1371/journal.pone.0123430
  14. Leite, J.P.; Duarte, M.; Paiva, A.M.; Ferreira-Da-Silva, F.; Matias, P.M.; Nunes, O.C.; Gales, L.. "Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929379140&partnerID=MN8TOARS.
    10.1371/journal.ppat.1003128
  15. Monteiro, C.; Pinheiro, M.; Fernandes, M.; Maia, S.; Seabra, C.L.; Ferreira-Da-Silva, F.; Reis, S.; Gomes, P.; Martins, M.C.L.. "A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells". Molecular Pharmaceutics 12 8 (2015): 2904-2911. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938303316&partnerID=MN8TOARS.
    10.1007/s10856-012-4639-x
  16. Leblebici, P.; Leblebici, M.E.; Ferreira-da-Silva, F.; Rodrigues, A.E.; Pais, L.S.. "Separation of human immunoglobulin G subclasses on a protein A monolith column". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 962 (2014): 89-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901949225&partnerID=MN8TOARS.
  17. Silva, D.S.; Pereira, L.M.G.; Moreira, A.R.; Ferreira-da-Silva, F.; Brito, R.M.; Faria, T.Q.; Zornetta, I.; et al. "The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-¿b P65". PLoS Pathogens 9 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880954175&partnerID=MN8TOARS.
    10.3390/molecules22081368
  18. Amaral, I.F.; Neiva, I.; Ferreira Da Silva, F.; Sousa, S.R.; Piloto, A.M.; Lopes, C.D.F.; Barbosa, M.A.; Kirkpatrick, C.J.; Pêgo, A.P.. "Endothelialization of chitosan porous conduits via immobilization of a recombinant fibronectin fragment (rhFNIII7-10)". Acta Biomaterialia 9 3 (2013): 5643-5652. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873199566&partnerID=MN8TOARS.
    10.1016/j.foodchem.2017.09.063
  19. Pereira, C.L.; Antunes, J.C.; Gonçalves, R.M.; Ferreira-Da-Silva, F.; Barbosa, M.A.. "Biosynthesis of highly pure poly-¿-glutamic acid for biomedical applications". Journal of Materials Science: Materials in Medicine 23 7 (2012): 1583-1591. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863314791&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.5b00113
  20. Duarte, M.; Ferreira-da-Silva, F.; Lünsdorf, H.; Junca, H.; Gales, L.; Pieper, D.H.; Nunes, O.C.. "Gulosibacter molinativorax ON4 T molinate hydrolase, a novel cobalt-dependent amidohydrolase". Journal of Bacteriology 193 20 (2011): 5810-5816. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053604140&partnerID=MN8TOARS.
    10.1021/bm2008235
  21. Garriga, D.; Vives-Adrián, L.; Buxaderas, M.; Ferreira-Da-Silva, F.; Almeida, B.; MacEdo-Ribeiro, S.; Pereira, P.J.B.; Verdaguer, N.. "Cloning, purification and preliminary crystallographic studies of the 2AB protein from hepatitis A virus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 10 (2011): 1224-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955155458&partnerID=MN8TOARS.
    10.1371/journal.ppat.1002325
  22. Castro, H.; Teixeira, F.; Romao, S.; Santos, M.; Cruz, T.; Flórido, M.; Appelberg, R.; et al. "Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: Insight into its novel chaperone activity". PLoS Pathogens 7 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80055096383&partnerID=MN8TOARS.
    10.1074/jbc.M111.223438
  23. Sárkány, Z.; Ikonen, T.P.; Ferreira-da-Silva, F.; Saraiva, M.J.; Svergun, D.; Damas, A.M.. "Solution structure of the soluble receptor for advanced glycation end products (sRAGE)". Journal of Biological Chemistry 286 43 (2011): 37525-37534. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054814015&partnerID=MN8TOARS.
    10.1128/JB.05054-11
  24. Antunes, J.C.; Pereira, C.L.; Molinos, M.; Ferreira-Da-Silva, F.; Dessi, M.; Gloria, A.; Ambrosio, L.; Gonca¸lves, R.M.; Barbosa, M.A.. "Layer-by-layer self-assembly of chitosan and poly(¿-glutamic acid) into polyelectrolyte complexes". Biomacromolecules 12 12 (2011): 4183-4195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856258191&partnerID=MN8TOARS.
    10.1107/S1744309111026261
  25. Pessoa, J.; Sárkány, Z.; Ferreira-da-Silva, F.; Martins, S.; Almeida, M.R.; Li, J.; Damas, A.M.. "Functional characterization of Arabidopsis thaliana transthyretin-like protein". BMC Plant Biology 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949472438&partnerID=MN8TOARS.
    10.1186/1471-2229-10-30
  26. Costa, R.; Ferreira-da-Silva, F.; Saraiva, M.J.; Cardoso, I.. "Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the kunitz protease inhibitor". PLoS ONE 3 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-51449096179&partnerID=MN8TOARS.
    10.1371/journal.pone.0002899
  27. Ferreira-da-Silva, F.; Pereira, P.J.B.; Gales, L.; Roessle, M.; Svergun, D.I.; Moradas-Ferreira, P.; Damas, A.M.. "The crystal and solution structures of glyceraldehyde-3-phosphate dehydrogenase reveal different quaternary structures". Journal of Biological Chemistry 281 44 (2006): 33433-33440. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845918427&partnerID=MN8TOARS.
    10.1074/jbc.M605267200
  28. Falcào Moreira, R.; Ferreira-Da-Silva, F.; Fernandes, P.A.; Moradas-Ferreira, P.. "Flocculation of Saccharomyces cerevisiae is induced by transformation with the GAP1 gene from Kluyveromyces marxianus". Yeast 16 3 (2000): 231-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033975906&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0061(200002)16:3<231::AID-YEA530>3.0.CO;2-C
Thesis / Dissertation
  1. "Glyceraldehyde-3-phosphate Dehydrogenase Isoform 1 from Kluyveromyces Marxianus: Structure and Functional Analysis". PhD, Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, 2006.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2014/12/08 Protein production and Biomolecular analysis @ Porto 2014 P4EU meeting
Vienna biocenter core facilities (Vienna, Austria)
2014/07/07 Biomolecular Interaction Analysis Portuguese Centre for Integrated Structural Biology (PCISBIO) day
ITQB; Instruct-Eric (Oeiras, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09/12 - 2022/06/15 Evaluating the protective role of TRSP vaccination against malaria
Co-supervisor of Joana Rafaela da Cunha Ribeiro
 Mestrado em biologia celular e molecular (Master)
Universidade do Porto Faculdade de Ciencias, Portugal
2012/09/15 - 2013/06/15 Characterization of the novel molinate hydrolase for bioremediation processes
Co-supervisor of José Pedro Santos Leite
 Mestrado integrado em Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2009/09/15 - 2010/07/15 Biosynthesis of Poly-y-glutamic acid and its application in y-PGA/Chitosan nanoparticles
Co-supervisor of Ana Catarina Leite Pereira
 Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2008/09/15 - 2009/06/15 Surface modification of chitosan scaffolds with recombinant fragments of fibronectin to promote endothelial cell adhesion
Co-supervisor of Ismael Fonseca Monteiro Resende Neiva
 Bioquímica (Degree)
Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciencias, Portugal

Instituto de Biologia Molecular e Celular, Portugal
2000/09/15 - 2001/06/15 Estudos sobre o endereçamento da isoforma de gliceraldeído-3-fosfato desidrogenase, proteina p37, para a parade de Saccharomyces cerevisiae
Co-supervisor of Jorge Augusto Machado Pereira
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciencias, Portugal

Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/10/25 - 2021/10/29 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2021 (https://meetings.embo.org/event/20-biomol-interactions) (2021/10/25 - 2021/10/29)
Workshop (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2018/10/29 - 2018/11/03 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2018 (https://meetings.embo.org/event/18-biomolecule) (2018/10/29 - 2018/11/03)
Workshop (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal
2018/03/19 - 2018/03/21 Talking molecules: the networks that shape the living world (2018/03/19 - 2018/03/21)
Congress (Member of the Scientific Committee)
 European Cooperation in Science and Technology, Belgium
2017/03/22 - 2017/03/24 Building Bridges in Biophysics (2017/03/22 - 2017/03/24)
Congress (President of the Organising Committee)
 European Cooperation in Science and Technology, Belgium
2016/11/07 - 2016/11/11 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2016 (https://bit.ly/EMBO_BIA_2016) (2016/11/07 - 2016/11/11)
Workshop (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal
2014/11/24 - 2014/11/28 EMBO Practical course "Biomolecular Interaction analysis: from molecules to cells" 2014 (https://bit.ly/EMBO_BIA_2014) (2014/11/24 - 2014/11/28)
Workshop (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal
2013/11/11 - 2013/11/12 4th Protein Production and Purification Partnership in Europe (P4EU) Meeting (https://www.ibmc.up.pt/events/upcoming-events/4th-p4eu-meeting) (2013/11/11 - 2013/11/12)
Meeting (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal
2011/11/12 - 2011/11/16 Biomolecular Interactions Analysis 2012 (One week practical course organized in the framework of the first call for INSTRUCT centre Training courses; Main organizer) (2011/11/12 - 2011/11/16)
Workshop (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal
2009 - 2009 A luz verde da medusa: como se faz ciência. ("The green light of the jellyfish: science in the making"). A workshop with experimental activities for high school students, focusing in the long lasting impact of fundamental science, using as an example the green fluorescent protein. (2009 - 2009)
Workshop (President of the Organising Committee)
 Instituto de Biologia Molecular e Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/11/03 - 2023/12/15 1st P4EU Structural Biology Workshop Series 2023 (virtual). A workshop dedicated to strutural biology concepts for non structural biologists and stratagies for construct design in recombinant protein production.
Workshop
 1st P4EU Structural Biology Workshop Series 2023 (Virtual)
Protein Production and Purification Partnership in Europe, Belgium
2023/04/17 - 2023/04/21 Instructor in the practical course "Protein aggregation, intrinsic disorder and phase separation in the era of machine learning" https://phasage.eu/training-school-4/
Workshop
 Protein aggregation, intrinsic disorder and phase separation in the era of machine learning
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2022/04/18 - 2022/04/22 Instructor in the practical course "Biomolecular condensates in cell function, aging and disease" https://www.i3s.up.pt/training-detail.php?v=217
Workshop
 Biomolecular condensates in cell function, aging and disease
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2019/11/06 - 2019/11/06 Biophysical Methods to Assess Protein Quality, a P4EU workshop
Workshop
 Biophysical Methods to Assess Protein Quality, a P4EU workshop at the NKI, Amsterdam
Antoni van Leeuwenhoek, Netherlands
2017/07/20 - 2017/07/21 EBSA 2017 Satellite Meeting "Biophysical approaches to protein folding and disease"
Meeting
 EBSA 2017 Satellite Meeting "Biophysical approaches to protein folding and disease"
European Biophysical Societies Association, United Kingdom
2013/07/01 - 2013/07/03 The 2nd SGC Protein Production Workshop (https://www.thesgc.org/workshop/protein-production-2013)
Workshop
 The 2nd SGC Protein Production Workshop
SGC Oxford, United Kingdom
2003/10/27 - 2003/10/29 Active teaching and learning in the biomolecular sciences
Workshop
 Active teaching and learning in the biomolecular sciences
Universidade do Porto, Portugal
2001/09/04 - 2001/09/14 Spetsai Summer School 2001
Workshop
 Protein Biology: from Synsthesis to funtion and disease
Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH, Germany

European Molecular Biology Laboratory, Germany

Federation of European Biochemical Societies, United Kingdom
1999/04/10 - 1999/04/16 Protein folding, degradation and molecular Chaperones (Franz-Ulrich hartl and Sue H Wickner organizers) Protein folding, modification and transport in the early secretory pathway (Linda M. Hendershot and randal J. Kaufman organizers)
Congress
 Protein folding, degradation and molecular Chaperones / Protein folding, modification and transport in the early secretory pathway
Keystone Symposia, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/09/25 Development of novel antobody-based Ataxin-3 bioimaging probes to track the progression of Machado-Joseph disease
(Thesis) Main arguer
 Beatriz Lourenço Vaz (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/01/09 Developing antimicrobial collagen/silk fibroin biocomposites with immobilized phages
(Thesis) Main arguer
 Ima Ghaeli (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2012 Structural Characterization of proteins associated to autophagy
(Thesis) Main arguer
 Ana Marisa Henriques Duarte Simões (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2008/07/03 Structural analysis of proteins involved in ubiquitin-proteasome degradation pathways
(Thesis) Main arguer
 Maria Bebiana Vigário da Silva Sá Moura (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciencias, Portugal

Association member

Society Organization name Role
2014/06/15 - Current Association of Resources for Biophysical Research in Europe (ARBRE) (https://www.arbre-biophysics.eu/) Founding member, MC member and Section Coordinator (Training and human capacity development)
2012/12/05 - Current Protein Production and Purification Partnership in Europe (P4EU) https://p4eu.org/ Member

Committee member

Activity description
Role 		Institution / Organization
2017/01/01 - 2019/12/31 Scientific Platforms (Core facilities) representative at the i3S Executive council
Member
 Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal

Consulting

Activity description Institution / Organization
2019/11/30 - 2022/06/15 Consultor no projecto la Caixa, CaixaImpulse: iPLUS - A 28 nucleotide sequence that activates gene expression and protein production LCF/TR/CI19/52460018 Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013/09/01 - Current Coordinator of the advanced course "Protein expression, Purification and Characterization" in the MCBiology PhD programme Biologia Molecular e Celular (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciencias, Portugal

Instituto de Biologia Molecular e Celular, Portugal
2009 - Current Invited yearly lecture on protein production, purification and characterization (Disciplina de Quimica Bioanalítica) Bioquímica (Mestrado integrado) Universidade do Porto Faculdade de Ciencias, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/10/18 - 2022/10/18 Lecture "Protein Production and Molecular Biophysics in a Core Facility of a Life Sciences Research Institute" in the course "Molecular-chemical methods for protein characterization" of the Master’s degree in Molecular and industrial biotechnology Department of Pharmacy and Biotechnology, University of Bologna (Master) Università degli Studi di Bologna Dipartimento di Farmacia e Biotecnologie, Italy
2013 - 2018 Yearly lecture "Recombinant protein production and purification" at the Structural Biology Module of the GABBA PhD program Programa Doutoral em Biologia Básica e Aplicada (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Faculdade de Ciencias, Portugal
2008 - 2010 Invited yearly lecture on protein production, purification and characterization (Disciplina de Engenharia de Proteínas e Desenho de Fármacos) Bioengenharia (Mestrado integrado) Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2009 Lectures (12 hours) on proteomics, protein structure and molecular interactions. Functional genomics course of the Biochemistry degree Bioquímica (Licenciatura) Cooperativa de Ensino Superior Politecnico e Universitario, Portugal
2008 - 2008 Lectures (20 hours) on proteomics, recombinant protei production and protein engineering. Molecular therapies Msc. Terapias Moleculares (Mestrado) Cooperativa de Ensino Superior Politecnico e Universitario, Portugal
1999/10/01 - 2005/06/30 Biochemistry Medicina Dentária (Licenciatura) Cooperativa de Ensino Superior Politecnico e Universitario, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/08/01 - Current Member of the Independent Review Board of canSERV (https://www.canserv.eu/)
Evaluator
 BBRI-ERIC (BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM), Austria Horizon Europe
2022/01/01 - Current Reviewer for ISIDORe INTEGRATED SERVICES FOR INFECTIOUS DISEASE OUTBREAK RESEARCH https://isidore-project.eu/
Evaluator
 Erinha - European Research Infrastructure on Highly Pathogenic Agents, Belgium Horizon Europe
2021/07/01 - Current Reviewer for MOSBRI: pan-European distributed research infrastructure in Molecular Biophysics (https://www.mosbri.eu/)
Evaluator
 Institut Pasteur, France Horizon Europe
2018/09/01 - Current Reviewer of applications for infrastructure access no Instruct-ERIC (pan-European distributed research infrastructure in Structural Biology) (https://instruct-eric.org/)
Evaluator
 Instruct-ERIC, United Kingdom
2020/05/01 - 2024/04/29 Reviewer of applications for infrastructure access in the iNEXT discovery (Infrastructure for NMR, EM and X-rays for Translational Research) https://inext-discovery.eu/
Evaluator
 Antoni van Leeuwenhoek, Netherlands Horizon Europe
2015/08/13 - 2019/08/01 Reviewer of applications for infrastructure access in the iNEXT (Infrastructure for NMR, EM and X-rays for Translational Research)
Evaluator
 iNEXT, Netherlands
Distinctions

Award

2011 Best Poster Prize "AIP56, an apoptogenic AB-toxin targeting NF-kB p65"
15th European Workshop on Bacterial Protein Toxins, Norway
2008 Prémio Pulido Valente Ciência - Neurociências e Implicações Clínicas (Pulido Valente award - Neurociences and Clinical implications)
Fundacao para a Ciencia e a Tecnologia, Portugal

Other distinction

2023 STAR Protocols Editors Collection 2023
iSTAR Protocols Editors, United States
2023 Top Cited paper in European Journal of Immunology (2022-2023)
John Wiley & Sons Inc, United States
1999 PhD fellowship (4 years) - PRAXIS XXI/BD/19777/99
Fundacao para a Ciencia e a Tecnologia, Portugal
1998 Research fellowship (2 years) PRAXIS XXI/BIC/4695/96
Fundacao para a Ciencia e a Tecnologia, Portugal