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Ermelindo Carreira Leal completed his PhD in Cell Biology in 2008 at the University of Coimbra, Faculty of Sciences and Technology and BSc in Biology in 2002 at the University of Coimbra, Faculty of Sciences and Technology. Dr Leal is Contracted Researcher at the Center for Neuroscience and Cell Biology (CNC-UC), Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Portugal. Dr. Ermelindo Leal has been working in the area of diabetic complications, with the interest of study novel therapies for the treatment of impaired diabetic wound healing. He has been the PI/co-PI of competitively funded projects from FCT and the European foundation for the study of diabetes (EFSD), including from the Pharma sector. Dr. Leal has extensive experience in the evaluation of therapeutic targets for chronic foot ulcers using pre-clinical validation models, such as cell cultures and wound healing animal models. Dr. Leal has expertise in the mechanisms leading to the progression of wound healing, such as modulation of inflammation, proliferation, angiogenesis, reactive oxygen species, extracellular matrix degradation/deposition, among others.
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Identification

Personal identification

Full name
Ermelindo Carreira Leal

Citation names

  • Leal, Ermelindo C
  • Leal, EC

Author identifiers

Ciência ID
5D10-6339-752E
ORCID iD
0000-0003-1748-9861

Email addresses

  • ecleal@cnc.uc.pt (Professional)
  • ecleal@cnc.uc.pt (Professional)

Telephones

Telephone
  • 919504536 (Professional)
  • 239820190 (Professional)

Addresses

  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Faculdade de Medicina, Polo I, Piso 1, Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2015/10 - 2015/10
Concluded
 Course in Laboratory Animal Science (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2008
Concluded
 Cell Biology (Doutoramento)
University of Coimbra, Faculty of Sciences and Technology, Portugal
"Mechanisms of cellular dysfunction in diabetic retinopathy: involvement of nitric oxide" (THESIS/DISSERTATION)
 Approved with distinction and honors
2002
Concluded
 Biology (Licenciatura)
University of Coimbra, Faculty of Sciences and Technology, Portugal
"-" (THESIS/DISSERTATION)
 17 out of 20
Affiliation

Science

Category
Host institution 		Employer
2019/01/15 - Current Contracted Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Others

Category
Host institution 		Employer
2019/01/15 - Current Doctorate researcher with the interest of study novel therapies for the treatment of impaired diabetic wound healing. Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2015/09/01 - 2019/01/15 Postdoctoral fellow with the project "Neuropeptide and microRNA regulation of endothelial progenitor cell function in diabetic wound healing", fellowship financed by FCT (SFRH/BPD/112883/2015) Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2009/01/01 - 2014/12/31 Postdoctoral fellow with the project "Dissecting the mechanisms of neuronal dysfunction in impaired wound healing in diabetes", fellowship financed by FCT (SFRH/BPD/46341/2008) Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2011/01/01 - 2013/03/02 Visiting postdoctoral fellow Beth Israel Deaconess Medical Center, Harvard Medical School, United States
2008/10/01 - 2008/12/31 Research assistant in the project entitled "Nanomedicine and new terapeutic strategies: development of supramolecular structures to the treatment of ophthalmologic diseases" financed by iCentro, PT Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
2008/01/01 - 2008/12/31 Research Assistant in the project entitled "Identification of Molecular and Cellular Mechanisms Underlying the Protective Effects of Calcium Dobesilate in Diabetic Retinopathy." Financed by OM PHARMA Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
2003/06/01 - 2008/12/09 PhD Student from the Doctoral programme in Experimental Biology and Biomedicine of the CNC, with the project "Mechanisms of cellular dysfunction in diabetic retinopathy: involvement of nitric oxide" Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
2007/01/01 - 2007/04/30 Research Assistant in the project entitled "Evaluation of the efficacy of a new formula on the prevention of cataract formation in a diabetic rat model." Financed by Oystershell, Belgium Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
2004/01/01 - 2005/06/30 Visiting PhD student Institution of Medical Sciences, Department of Ophthalmology, University of Aberdeen, UK, United Kingdom
2001/09/01 - 2002/07/15 Undergraduate training with the project “Nitric oxide involvement in mitochondrial dysfunction and caspase-3 activation mediated by AMPA receptor neurotoxicity" Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
Projects

Grant

Designation Funders
2023/01/01 - 2025/12/31 MMETA4Obesity - Mycobiota homeostasis under the regulation of adenosine receptors as pivotal players in obesity
MMETA4Obesity
Researcher
Universidade de Coimbra, Portugal
2023/08/01 - 2024/12/31 A peptide-decorated anti-microbial and pro-healing hyaluronic acid dressing to promote diabetic wound healing
Peptide
Research Fellow
RCSI School of Medicine, Ireland
 European Foundation for the Study of Diabetes
Ongoing
2017/09/01 - 2020/03/31 Inhibition of macrophage protein tyrosine phosphatase 1B (PTP1B) as a novel therapy for improved wound healing in diabetes
Diabetes UK
Collaborador
University of Aberdeen, United Kingdom
 Diabetes UK
2017/03 - 2019/02 Microcare - Microbiome of diabetic wounds: early diagnosis, prognosis and therapy
FIS-FIS-2015-01_DIA_20150630-144
Researcher
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
 INFARMED - National Authority of Medicines and Health Products
2015/12/01 - 2017/12/31 Combination therapy synergistically accelerates diabetic wound closure
EFSD/Novartis Programme 2015
Researcher
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
 European Association for the Study of Diabetes
2013/06 - 2016/05 Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics.
grant.Provided by PTCRIS: 124979
EXCL/DTP-PIC/0069/2012
Invited Scientist Fellow
Associacao Protectora dos Diabeticos de Portugal, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Stichting Weten

Fundação para a Ciência e a Tecnologia
Concluded
2012/09/01 - 2015/12/31 Promoting endothelial progenitor cell function in diabetic wound healing
EFSD/JDRF/Novo Nordisk European Programme in Type 1 Diabetes Research
Principal investigator
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
 European Association for the Study of Diabetes
2012/04 - 2014/09 Neuropeptide release in wounds: a new therapeutic approach for the treatment of diabetic foot ulceration
grant.Provided by PTCRIS: 121109
PTDC/SAU-FAR/121109/2010
Principal investigator
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
2010/05 - 2013/10 Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides
grant.Provided by PTCRIS: 98567
PTDC/SAU-MII/098567/2008
Post-doc Fellow
Center for Neurocience and Cell Biology, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/09 Impact of methamphetamine on the blood-brain barrier: unmasking the underlying mechanisms and the role of neuroinflammation
grant.Provided by PTCRIS: 98685
PTDC/SAU-FCF/098685/2008
Invited Scientist Fellow
Faculty of Mecidine, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
2010/06/01 - 2013/03/01 Role of Neuropeptides in Diabetic Foot Problems
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE/5R01NS066205-02/US
1R01NS066205
Post-doc Fellow
Beth Isrel Deaconess Medical Center, Havard Medical School, United States
 National Institutes of Health
Concluded
2011/09/30 - 2013/03 Mechanisms of Neuropeptides Action in Diabetes
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES/1R01DK091949-01A1/US
1R01DK091949
 National Institutes of Health
2011/09/01 - 2012/12/31 Sitagliptin as a potential therapeutic option for the treatment of diabetic retinopathy: novel insights into the mechanisms of action
EFSD/JDRF/GlaxoSmithKline
Invited Scientist Fellow
Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
 European Association for the Study of Diabetes
Concluded
2011/03/01 - 2012/02/29 Characterization of the endothelial dysfunction in the retina of animal models of type 1 diabetes: potential therapeutic effects of sitagliptin
GIFT/SPD/2011
Invited Scientist Fellow
Sociedade Portuguesa de Diabetologia
Concluded
2009/09/01 - 2010/12/31 Dissecting mechanisms of neuronal dysfunction in wound healing in diabetes type 1
EFSD/JDRF/Novo Nordisk European Programme in Type 1 Diabetes Research
Post-doc Fellow
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
 European Association for the Study of Diabetes
Concluded
2008/09/01 - 2008/12/31 Nanomedicine and new terapeutic strategies: development of supramolecular structures to the treatment of ophthalmologic diseases
iCentro/NNTS/2008/01
Research Fellow
Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
Concluded
2008/01/01 - 2008/08/31 Evaluation of the efficacy of a new formula on the prevention of cataract formation in a diabetic rat model
Oystershell, Belgium
Invited Scientist Fellow
Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
 Oystershell
2008/01/01 - 2008/08/31 Evaluation of the potential protective effect of calcium dobesilate against inflammation and oxidative/nitrosative stress in the retina of a diabetic rat model
PHARMA PROJECT: DX 2008/01
Researcher
Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
2005/01/01 - 2005/12/31 Regulation of the expression of the type 1 IL-1 receptor in the retina
GAI 10/05
PhD Student Fellow
Faculty of Mecidine, University of Coimbra, Portugal
 Faculty of Mecidine, University of Coimbra
2002/10 - 2005/12 Mechanisms of cell degeneration in diabetic retinopathy
grant.Provided by PTCRIS: 38545
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/10/01 - 2019/01/14 Neuropeptide and microRNA regulation of endothelial progenitor cell function in diabetic wound healing
SFRH/BPD/112883/2015
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2013/12/31 DISSECTING THE MECHANISMS OF NEURONAL DYSFUNCTION IN IMPAIRED WOUND HEALING IN DIABETES
SFRH/BPD/46341/2008
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/06/01 - 2010/12/31 Regulation of AMPA receptors by hyperglycemia in the retina
PTDC/SAU-NEU/71228/2006
grant.Provided by PTCRIS: 71228
PhD Student Fellow
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Leal, E.C.; Ambrósio, A.F.; Cunha-Vaz, J.. "Nitric oxide synthase in retinal vascular diseases". In Diabetic Retinopathy, edited by Robert D. Stratton; William W. Hauswirth; Thomas W. Gardner, 529-544. New York, United States: Springer Science & Business Media, 2012.
    10.1007/978-1-61779-606-7_26
  2. Leal, E.; Ambrósio, A.F.. "4.3. Neovascularization in diabetic retinopathy". In Diabetic Retinopathy. 2010.
    10.1142/9789814304443_0004
  3. Leal, Ermelindo C. "Neovascularization in Diabetic Retinopathy". In Diabetic Retinopathy, 150-159. Madrid, Spain: Spanish Society of Ophthalmology, 2006.
Conference poster
  1. Leal, Ermelindo C; Figueiredo, Ana; Carvalho, Eugenia. Corresponding author: Leal, Ermelindo C. "Neurotensin Improves Endothelial Progenitor Cell Function In Diabetic Wound Healing. *corresponding author". Paper presented in 80th Scientific Session ADA, 2020.
  2. Figueiredo, Ana; Leal, Ermelindo C; Santos, Diana; Gasiunaite, Gerda; Delibegovic, Mirela; Carvalho, Eugenia. Corresponding author: Leal, Ermelindo C. "Protein Tyrosine Phosphatase 1B Inhibitor, MSI-1436, Promotes M2 Macrophage Polarization And Decreases Oxidative Stress In Human Monocytes Under High Glucose Conditions. *corresponding author". Paper presented in 80th Scientific Sessions ADA, 2020.
  3. Figueiredo, A; Leal, EC; Diana, S; Gasiunaite, G; Delibegovic, M; Carvalho, E. Corresponding author: Leal, EC. "Protein tyrosine phosphatase 1B inhibition improves diabetic wound healing via modulation of macrophage phenotype". Trabalho apresentado em Center for Innovative Biomedicine and Biotechnology Meeting. *corresponding author". Paper presented in Center for Innovative Biomedicine and Biotechnology Meeting, 2019.
  4. Leal, EC; Figueiredo, A; Carvalho, E. Corresponding author: Leal, EC. "Neuropeptide effect on endothelial progenitor cell function in diabetic wound healing. *corresponding author". Paper presented in Center for Innovative Biomedicine and Biotechnology Meeting, 2019.
  5. Figueiredo, A; Leal, EC; Gasiunaite, G; Delibegovic, M; Carvalho, E. Corresponding author: Leal, EC. "Protein tyrosine phosphatase 1B inhibition plays a role in the macrophage phenotype under high glucose conditions: potential therapy for diabetic wound healing. *corresponding author". Paper presented in 55th Annual Meeting of the European Associationfor the Study of Diabetes, 2019.
  6. Gasiunaite, G; Leal, EC; Figueiredo, A; Wilson, HM; Rajnicek, A; Carvalho, E; Delibegovic, M. "Inhibition of PTP1B for improved diabetic wound healing.". Paper presented in 55th Annual Meeting of the EuropeanAssociation for the Study of Diabetes, 2019.
  7. Gasiunaite, G; Leal, EC; Figueiredo, A; Baillie, J; Wilson, HM; Rajnicek, A; Carvalho, E; Delibegovic, M. "PTP1B inhibition for improved diabetic wound healing". Paper presented in Physiology 2019 conference, 2019.
  8. Figueiredo, A; Leal, EC; Diana, S; Gasiunaite, G; Delibegovic, M; Carvalho, E. Corresponding author: Leal, EC. "A inibição da proteína tirosina fosfatase 1B potencia o fenótipo de macrófagos anti-inflamatórios, em condições de alta glucose, podendo beneficiar a cicatrização de feridas diabéticas. *corresponding author". Paper presented in 16º Congresso Português de Diabetes, 2019.
  9. Figueiredo, A; Leal, EC; Gasiunaite, G; Delibegovic, M; Carvalho, E. Corresponding author: Leal, EC. "Inibiçãoda proteína tirosina fosfatase 1B como uma nova terapia para a ulceraçãocrónica do pé diabético. *corresponding author". Paper presented in 15º Congresso Português de Diabetes organizado pela Sociedade Portuguesa de Diabetologia, 2019.
  10. Maranha, A; Alarico, S; Leal, EC; Carvalho, E; Pereira, SG; Empadinhas, N. "Microcare project: the impact and potentiality of microbes in diabetic skin and ulcers". Paper presented in 15th Congresso Português de Diabetes, 2019.
  11. Leal, Ermelindo C; Petkovic, M; Leal, EC; Sørensen, AE; Willemoes, RJ; Jørgensen, PT; Wengel, J; Carvalho, E; Dalgaard, LT. "Inhibition of miR-146a and miR-29a improves diabetic wound healing in a mouse model of diabetes type 1". Paper presented in 15th Portuguese Diabetes Congress, 2019.
Journal article
  1. Aryane Cruz Oliveira Pinho; Diana Santos; Paulo J. Oliveira; Ermelindo Carreira Leal; Eugenia Carvalho. "Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study". European Journal of Clinical Investigation (2024): https://doi.org/10.1111/eci.14128.
    10.1111/eci.14128
  2. Jessica Da Silva; Ermelindo C. Leal; Eugénia Carvalho; Eduardo A. Silva. "Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24129900.
    10.3390/ijms24129900
  3. Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho. "Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model". Journal of Molecular Endocrinology (2023): https://doi.org/10.1530/JME-22-0122.
    10.1530/JME-22-0122
  4. Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal. "Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers". Antibiotics (2023): https://doi.org/10.3390/antibiotics12030467.
    10.3390/antibiotics12030467
  5. Ermelindo Carreira Leal; Eugenia Carvalho. "Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231912043.
    10.3390/ijms231912043
  6. Aryane Cruz Oliveira Pinho; Diana Santos; Inês Baldeiras; Ana Burgeiro; Emelindo C Leal; Eugenia Carvalho. "Mitochondrial respiration in thoracic perivascular adipose tissue of diabetic mice". Journal of Endocrinology (2022): https://doi.org/10.1530/JOE-21-0446.
    10.1530/JOE-21-0446
  7. Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo Cerqueira de; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al. "Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration". (2022): http://hdl.handle.net/10316/99911.
    https://doi.org/10.1016/j.omtn.2022.03.018
  8. Marija Petkovic; Ermelindo C Leal; Ines Alves; Chanda Bose; Philip T Palade; Preeti Singh; Sanjay Awasthi; et al. "Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway". The Journal of Nutritional Biochemistry 98 (2021): 108817-108817. https://doi.org/10.1016/j.jnutbio.2021.108817.
    10.1016/j.jnutbio.2021.108817
  9. Leal, Ermelindo C; F. Moura, Liane I.; Pirzgalska, Roksana M.; Marques-da-Silva, Dorinda; Ledent, Catherine; Köfalvi, Attila; Carvalho, Eugenia. Corresponding author: Leal, Ermelindo C. "Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin. *corresponding author". Experimental Gerontology 154 (2021): 111528. http://dx.doi.org/10.1016/j.exger.2021.111528.
    10.1016/j.exger.2021.111528
  10. Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; et al. "Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use". STEM CELLS Translational Medicine (2021): https://doi.org/10.1002/sctm.20-0376.
    10.1002/sctm.20-0376
  11. Mouritzen, Michelle V; Petkovic, Marija; Qvist, Katrine; Poulsen, Steen S; Alarico, Susana; Leal, Ermelindo C; Dalgaard, Louise T; et al. "Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota". Molecular Therapy: Methods & Clinical Development (2021): https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(21)00023-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2329050121000231%3Fshowall%3Dtrue.
    In press • https://doi.org/10.1016/j.omtm.2021.02.008
  12. Da Silva, Jessica; Leal, Ermelindo C.; Carvalho, Eugenia; Jessica Da Silva; Leal, Ermelindo C; Eugénia Carvalho. Corresponding author: Leal, Ermelindo C. "Bioactive Antimicrobial Peptides as Therapeutic Agents for Infected Diabetic Foot Ulcers". Biomolecules (2021): http://hdl.handle.net/10316/103768.
    https://doi.org/10.3390/biom11121894
  13. Marija Petkovic; Anja Elaine Sørensen; Leal, Ermelindo C; Eugenia Carvalho; Louise Torp Dalgaard; Seraphim PM*; Leal, Ermelindo C; et al. "Mechanistic Actions of microRNAs in Diabetic Wound Healing". Cells 9 10 (2020): 2228-2228. https://doi.org/10.3390/cells9102228.
    10.3390/cells9102228
  14. FIGUEIREDO, ANA; Leal, Ermelindo C; SANTOS, DIANA; GASIUNAITE, GERDA; DELIBEGOVIC, MIRELA; CARVALHO, EUGENIA. Corresponding author: Leal, Ermelindo C. "536-P: Protein Tyrosine Phosphatase 1B Inhibitor MSI-1436 Promotes M2 Macrophage Polarization and Decreases Oxidative Stress in Human Monocytes under High-Glucose Conditions. *corresponding author". Diabetes 69 Supplement (2020): http://dx.doi.org/10.2337/db20-536-p.
    10.2337/db20-536-p
  15. Figueiredo A; Leal, Ermelindo C; Carvalho E. Corresponding author: Leal, Ermelindo C. "Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes. *corresponding author". Pharmacological research (2020): http://europepmc.org/abstract/med/32504834.
    10.1016/j.phrs.2020.104977
  16. João Moura*; Anja Sørensen*; Leal, Ermelindo C; Rikke Svendsen; Lina Carvalho; Rie Juul Willemoes; Per Trolle Jørgensen; et al. Corresponding author: Leal, Ermelindo C. "microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation. *equal contribution". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-42309-4.
    10.1038/s41598-019-42309-4
  17. Moura, J; Madureira, P; Leal, E C; Fonseca, A C; Carvalho, E. "Immune aging in diabetes and its implications in wound healing.". Clinical immunology (Orlando, Fla.) 200 (2019): 43-54. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30735729&KeyUID=MEDLINE:30735729.
    10.1016/j.clim.2019.02.002
  18. Antunes, Helena; Cardoso, Renato; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo; Jiménez-Balsa, Adrián; Lino, Miguel; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Tissue Regeneration". ACS Nano 13 8 (2019): 8694-8707. http://hdl.handle.net/10316/92386.
    https://doi.org/10.1021/acsnano.9b00376
  19. Voabil, P.; Liberal, J.; Leal, EC; Bauer, J.; Cunha-Vaz, J.; Santiago, A.R.; Ambrósio, A.F.. "Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model". Ophthalmic Research 58 3 (2017): 150-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027095862&partnerID=MN8TOARS.
    10.1159/000478784
  20. Leal, Ermelindo C; Pirzgalska, R.; Marques-da-Silva, D.; Moura, L.; Espinoza, D.; Ledent, C.; Kofalvi, A.; Carvalho, E.. Corresponding author: Leal, Ermelindo C. "Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression. *corresponding author". Diabetologia 60 (2017): S119-S119. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408315001031&KeyUID=WOS:000408315001031.
  21. Petkovic, M.; Sorensen, A. E.; Leal, E. C.; Moura, J.; Willemoes, R. J.; Jorgensen, P. T.; Wengel, J.; Carvalho, E.; Dalgaard, L. T.. "Regulation of miRNA-146a and miR-29a during wound healing in a mouse model of type 1 diabetes". Diabetologia 60 (2017): S120-S120. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408315001034&KeyUID=WOS:000408315001034.
  22. Quinn, K.P.; Leal, E.C.; Tellechea, A.; Kafanas, A.; Auster, M.E.; Veves, A.; Georgakoudi, I.. "Diabetic wounds exhibit distinct microstructural and metabolic heterogeneity through label-free multiphoton microscopy". Journal of Investigative Dermatology 136 1 (2016): 342-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959460751&partnerID=MN8TOARS.
    10.1038/JID.2015.371
  23. Tellechea, A.; Leal, E.C.; Kafanas, A.; Auster, M.E.; Kuchibhotla, S.; Ostrovsky, Y.; Tecilazich, F.; et al. "Mast cells regulate wound healing in diabetes". Diabetes 65 7 (2016): 2006-2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975889733&partnerID=MN8TOARS.
    10.2337/db15-0340
  24. Maione, A.G.; Brudno, Y.; Stojadinovic, O.; Park, L.K.; Smith, A.; Tellechea, A.; Leal, E.C.; et al. "Three-dimensional human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds". Tissue Engineering - Part C: Methods 21 5 (2015): 499-508. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928943198&partnerID=MN8TOARS.
    10.1089/ten.tec.2014.0414
  25. Leal, E.C.; Carvalho, E.; Tellechea, A.; Kafanas, A.; Tecilazich, F.; Kearney, C.; Kuchibhotla, S.; et al. "Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype". American Journal of Pathology 185 6 (2015): 1638-1648. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929889091&partnerID=MN8TOARS.
    10.1016/j.ajpath.2015.02.011
  26. Tellechea, A.; Silva, E.A.; Min, J.; Leal, E.C.; Auster, M.E.; Pradhan-Nabzdyk, L.; Shih, W.; Mooney, D.J.; Veves, A.. "Alginate and DNA gels are suitable delivery systems for diabetic wound healing". International Journal of Lower Extremity Wounds 14 2 (2015): 146-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937551409&partnerID=MN8TOARS.
    10.1177/1534734615580018
  27. Tellechea, Ana; Kafanas, Antonios; Leal, Ermelindo C.; Auster, Michael E.; Kuchibhotla, Sarada; Ostrovsky, Yana; Carvalho, Eugenia; et al. "Mast Cell Stabilization: A Potential Treatment for Diabetic Wounds". Diabetes 64 2 (2015): A182-A183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359482700702&KeyUID=WOS:000359482700702.
  28. Moura, L.I.F.; Dias, A.M.A.; Suesca, E.; Casadiegos, S.; Leal, E.C.; Fontanilla, M.R.; Carvalho, L.; et al. "Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 1 (2014): 32-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887730276&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.10.009
  29. Gonçalves, A.; Marques, C.; Leal, E.; Ribeiro, C.F.; Reis, F.; Ambrósio, A.F.; Fernandes, R.. "Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 9 (2014): 1454-1463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903487864&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.04.013
  30. Leal, E. C.; Tellechea, A.; Kuchibhotla, S.; Auster, M. E.; LoGerfo, F. W.; Pradhan-Nabzdyk, L.; Carvalho, E.; Veves, A.. "SP regulates macrophage function in diabetic wound healing". Diabetologia 57 (2014): S112-S112. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000344386100251&KeyUID=WOS:000344386100251.
  31. Carvalho E; Cruz MT; Leal EC; Moura LI; Silva L; Tellechea A; Moura, Liane I. F.; et al. "Neurotensin Modulates the Migratory and Inflammatory Response of Macrophages under Hyperglycemic Conditions.". (2013): http://europepmc.org/abstract/med/24000330.
    10.1155/2013/941764
  32. Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; de Sousa, H.C.; Carvalho, E.; Moura, Liane I. F.; et al. "Chitosan-based dressings loaded with neurotensin-an efficient strategy to improve early diabetic wound healing". Acta Biomaterialia (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886910358&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.09.040
  33. Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al. "Increased skin inflammation and blood vessel density in human and experimental diabetes". International Journal of Lower Extremity Wounds 12 1 (2013): 4-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254399&partnerID=MN8TOARS.
    10.1177/1534734612474303
  34. Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al. "Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84892726746&partnerID=MN8TOARS.
    10.1371/journal.pone.0083314
  35. Tellechea, A.; Leal, E. C.; Tecilazich, F.; Auster, M.; Nabzdyk, L. Pradhan; Veves, A.. "M1/M2 SKIN MACROPHAGE PHENOTYPE IS ALTERED IN DIABETES". Wound Repair and Regeneration 21 2 (2013): A45-A45. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000315914400127&KeyUID=WOS:000315914400127.
  36. Leal, E. C.; Carvalho, E.; Tellechea, A.; Kuchibhotla, S.; Auster, M.; LoGerfo, F. W.; Pradhan, L.; Veves, A.. "Impaired wound healing in diabetes through substance p dependent mechanism". European Journal of Clinical Investigation 43 2 (2013): 99-99. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000286&KeyUID=WOS:000317141000286.
  37. Gonçalves, A.; Leal, E.; Paiva, A.; Teixeira Lemos, E.; Teixeira, F.; Ribeiro, C.F.; Reis, F.; Ambrósio, A.F.; Fernandes, R.. "Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model". Diabetes, Obesity and Metabolism 14 5 (2012): 454-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859444000&partnerID=MN8TOARS.
    10.1111/j.1463-1326.2011.01548.x
  38. Doupis, John; Giurini, John E.; Gnardellis, Charalambos; Kafanas, Antonios; Leal, Ermelindo; Lyons, Thomas E.; Pradhan, Leena; et al. "Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration". Diabetes 61 11 (2012): 2937-2947.
    10.2337/db09-1421
  39. Ambrosio, Antonio F.; Aveleira, Celia A.; Baptista, Filipa I.; Castilho, Aurea F.; Fernandes, Carolina R.; Leal, Ermelindo C.; Meirinhos, Rita I.; Simoes, Nuria F.. "Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity". Plos One 7 8 (2012):
    10.1371/journal.pone.0042428
  40. Tellechea, A.; Leal, E. C.; Kafanas, A.; Kuchibhotla, S.; Auster, M.; Pradhan, L.; Carvalho, E.; Veves, A.. "MAST CELL DYSFUNCTION IMPAIRS WOUND HEALING IN DIABETES". Wound Repair and Regeneration 20 2 (2012): A42-A42. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300943100118&KeyUID=WOS:000300943100118.
  41. Martins, T.; Baptista, S.; Gonçalves, J.; Leal, E.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; et al. "Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9". Brain Research 1411 (2011): 28-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052037570&partnerID=MN8TOARS.
    10.1016/j.brainres.2011.07.013
  42. Carvalho, E.; Espinoza, D.; Koefalvi, A.; Leal, E.. "Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin". Diabetologia 54 (2011): S458-S458. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302326&KeyUID=WOS:000307671302326.
  43. Zabolotny, J. M.; Tellechea, A.; Leal, EC; Kontoes, I.; Kuchibhotla, S.; Pradhan, L.; Carvalho, E.; Veves, A.. "Protein tyrosine phophatase 1B (PTP1B) deficiency promotes wound healing". Diabetologia 54 (2011): S471-S471. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302362&KeyUID=WOS:000307671302362.
  44. Carvalho, E.; Maio, V.; Leal, E.. "Neurotensin decreases TNF alpha-induced cell death in keratinocytes and macrophages: possible important role in diabetic wound healing". Diabetologia 54 (2011): S472-S473. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302366&KeyUID=WOS:000307671302366.
  45. Moura, L.; Dias, A.; Leal, E.; Sousa, H.; Carvalho, E.. "Neurotensin and chitosan-based dressings: a new approach for diabetic wound healing treatment". Diabetologia 54 (2011): S472-S472. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302365&KeyUID=WOS:000307671302365.
  46. Tellechea, A.; Zabolotny, J. M.; Pradhan, L.; Leal, E.; Kafanas, A.; Kuchibhotla, S.; Carvalho, E.; Veves, A.. "Impaired mast cell function affects wound healing in diabetes". Diabetologia 54 (2011): S471-S471. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302361&KeyUID=WOS:000307671302361.
  47. Ambrosio, AF; Aveleira, C; Baptista, F; Castilho, A; Fernandes, C; Leal, E; Simoes, N. "High glucose and interleukin-1 beta downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism". Cytokine 49 3 (2010): 279-286.
    10.1016/j.cyto.2009.11.014
  48. Carvalho, E; Leal, E; Tellechea, A; Pradhan, L; Kuchibhotla, S; Logerfo, FW; Veves, A. "The Role of Mast Cells in Wound Healing in Diabetes". Diabetes 59 (2010): A327-A327. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278844601526&KeyUID=WOS:000278844601526.
  49. Tellechea, A; Carvalho, E; Leal, E; Kuchibhotla, S; Pradhan, L; Logerfo, FW; Veves, A. "Angiogenic and Inflammatory Markers in Diabetic Wound Healing". Diabetes 59 (2010): A325-A325. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278844601517&KeyUID=WOS:000278844601517.
  50. Leal, E; Tellechea, A; Moura, L; Veves, A; Carvalho, E. "The Role of Neurotensin in Wound Healing in Diabetic and iNOS Knockout Mice". Diabetes 59 (2010): A269-A269. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278844601309&KeyUID=WOS:000278844601309.
  51. Ambrosio, AF; Aveleira, CA; Baptista, FI; Castilho, AF; Leal, EC. "Muller cells do not influence leukocyte adhesion to retinal endothelial cells". Ocular Immunology and Inflammation 16 4 (2008): 173-179.
    10.1080/09273940802204535
  52. Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; et al. "High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway". Experimental Eye Research 88 5 (2008): 983-991. http://hdl.handle.net/10316/10103.
    https://doi.org/10.1016/j.exer.2008.12.010
  53. Leal, E.C.; Manivannan, A.; Hosoya, K.-I.; Terasaki, T.; Cunha-Vaz, J.; Ambrósio, A.F.; Forrester, J.V.; et al. "Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy". Investigative Ophthalmology and Visual Science 48 11 (2007): 5257-5265. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449108616&partnerID=MN8TOARS.
    10.1167/iovs.07-0112
  54. Leal, EC; Manivannana, A; Aveleira, C; Serra, A; Castilho, A; Terasaki, T; Hosoya, KI; et al. "Leukocyte adhesion and blood retinal barrier (BRB) breakdown in diabetic retinopathy (DR): Role of nitric oxide (NO)". Investigative Ophthalmology & Visual Science 46 (2005): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000227980400417&KeyUID=WOS:000227980400417.
  55. Leal, E.C.; Santiago, A.R.; Ambrósio, A.F.. "Old and new drug targets in diabetic retinopathy: From biochemical changes to inflammation and neurodegeneration". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 421-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144443684&partnerID=MN8TOARS.
    10.2174/1568007054546162
  56. Araújo, Inês M.; Verdasca, Maria J.; Leal, Ermelindo C.; Bahr, Ben A.; Ambrósio, António F.; Carvalho, Arsélio P.; Carvalho, Caetana M.; et al. "Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons". Journal of Neurochemistry 91 6 (2005): 1322-1331. http://hdl.handle.net/10316/8419.
    https://doi.org/10.1111/j.1471-4159.2004.03043.x
  57. Leal, EC; Aveleira, C; Sa, M; Serra, A; Castilho, A; Terasaki, T; Hosoya, KI; Cunha-Vaz, J; Ambrosio, AF. "Rat retinal endothelial cell dysfunction induced by hyperglycemia and oxidative stress: additive effects?". Investigative Ophthalmology & Visual Science 45 (2004): U88-U88. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000223338200430&KeyUID=WOS:000223338200430.
  58. Araújo, Inês M.; Ambrósio, António Francisco; Leal, Ermelindo C.; Verdasca, Maria João; Malva, João Oliveira; Soares-da-Silva, Patrício; Carvalho, Arsélio Pato; et al. "Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A Comparative Study between Carbamazepine, Oxcarbazepine, and Two New Putative Antiepileptic Drugs, BIA 2-024 and BIA 2-093". Epilepsia 45 12 (2004): 1498-1505. http://hdl.handle.net/10316/8422.
    https://doi.org/10.1111/j.0013-9580.2004.14104.x
  59. Araújo, I.M.; Ambrósio, A.F.; Leal, E.C.; Santos, P.F.; Carvalho, A.P.; Carvalho, C.M.. "Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons". Journal of Neurochemistry 85 3 (2003): 791-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-17944400535&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Leal, Ermelindo Carreira. "Mechanisms of cellular dysfunction in diabetic retinopathy : involvement of nitric oxide". PhD, 2008. http://hdl.handle.net/10316/9637.

Intellectual property

Provisional application for patent
  1. 2024. "Alginate-based hydrogels for sustained antimicrobial peptide delivery to enhance wound healing in diabetes".
    Disclosed

Other

Other output
  1. Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use. 2020. Cardoso R; Rodrigues S; Gomes CF; Duarte F; Romao M; Leal E; Freire P; Neves R; Simões-Correia J. http://europepmc.org/abstract/PPR/PPR256101.
    10.1101/2020.12.18.423416
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/03/13 Mouse Models of Infections in Diabetic Wound Healing 3rd Diabetic Wound Healing Workshop
Roskilde Univresity (Roskilde, Denmark)
2020/03/07 Neuropeptídeo melhora a função das células progenitoras endoteliais na cicatrização de feridas diabéticas 16º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2020/03/07 A inibição de miR-146a e miR-29a promove o fecho de feridas em um modelo animal de diabetes tipo 1 16º Congresso Nacional de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2019/09/18 Neuropeptide regulation of endothelial progenitor cell function in diabetic wound healing 55th Annual Meeting of the European Association for the Study of Diabetes
European Association for the Study of Diabetes (Barcelona, Spain)
2019/09/18 Inhibition of miR-29a and miR-146a accelerates the wound closure in a mouse model of type 1 diabetes 55th Annual Meeting of the European Association for the Study of Diabetes
European Association for the Study of Diabetes (Barcelona, Spain)
2019/01/03 Premature skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression 2nd Diabetic Wound Healing Workshop
Roskilde University (Roskilde, Denmark)
2018/05/16 Mechanistic Insights and Therapeutic Strategies in diabetic wound healing iCBR Seminar
(Coimbra, Portugal)
2016/12/19 The role of neuropeptides in diabetic foot ulcers 1st Meeting on Biomedical Research @ UC. CNC.IBILI
CNC.IBILI, University of Coimbra (Coimbra, Portugal)
2016/04/07 Diabetic Foot Ulceration: possible therapeutic targets World health day 2016. Simposium: Research in Diabetes.
Endocrinology Service of Hospital Center of Baixo Vouga and IBIMED, University of Aveiro
2016/04/04 Diabetes and its macro- and microvascular complications Course Metabolism and Aging/Doctoral programme in Biology and Experimental Biomedicine
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2015/04/20 Unravel the mechanisms of diabetic complications using animal models Advanced Course in Animal models in human diseases
Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2015/03/30 Therapeutic targets for the treatment of wound healing in diabetes Diabetic Wound Healing Workshop
Roskilde University (Roskilde, Denmark)
2015/02/05 Biomarkers in diabetic foot ulceration III Congress in diabetic foot ulceration
Nursing school of Coimbra (Coimbra, Portugal)
2013/04/05 Impaired wound healing and peripheral neuropathy in diabetes: from mechanistic insights to potential therapeutic targets CNC Seminar
Center for Neurosciences and Cell Biology (Coimbra, Portugal)
2011/12/20 Neurotensin improves diabetic wound healing via inducible nitric oxide synthase IX Annual CNC Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2008/11/21 Projects for pharmacology development Technology transfer. Opportunities for investigation in collaboration with national and international companies
University of Coimbra, Faculty of Medicine (Coimbra, Portugal)
2008/02/11 Mechanisms of cell dysfunction in early Diabetic Retinopathy Young Scientist Seminar
Center for Neuroscience and Cell Biology (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10/26 - 2023/10/26 THE EFFECT OF INNOVATIVE ANTIMICROBIAL PEPTIDES IN DIABETIC WOUND HEALING
Supervisor
 Master in Biomedicine (Master)
Universidade de Coimbra, Portugal
2022 - 2022 Hidrogel de alginato e quitosano com libertação controlada de peptídeos antimicrobianos para controlar a infeção do pé diabético / Alginate-chitosan hydrogel with controlled release of antimicrobial peptides to control diabetic foot infection
Supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019 BMP-7 effects on wound healing in diabetic mice -a pilot study
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Inhibition of protein tyrosine phosphatase 1B as a novel therapy for chronic diabetic foot ulceration
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/01 - 2017/06/01 High fat diet and voluntary physical activity affect the biology of the skin
Supervisor
 BSc in Biotechnology (Degree)
Universidad de Zaragoza, Spain
2013/09/01 - 2014/06/01 Mechanisms of wound healing in diabetes
Supervisor
 Master in Biotechnology (Master)
VIT University, India
2009/09 - 2014/06 Cellular and molecular mechanisms of impaired wound healing in diabetes : understanding the role of substance P and mast cells
Co-supervisor
 Molecular and Cell Biology (PhD)
University of Coimbra, Faculty of Pharmacy, Portugal
2009 - 2013 Development of Novel Therapeutic Approaches for Wound Healing in Diabetes
Co-supervisor
 Biotechnology (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/09/01 - 2011/06/01 The role of neurotensin in diabetic wound healing
Supervisor
 BSc in Biology (Degree)
Università degli Studi di Napoli Federico II Dipartimento di Biologia, Italy
2009 - 2009 Development of Novel Therapeutic Approaches for Wound Healing in Diabetes
Supervisor
 Engenharia Química (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2009 Cellular and Molecular Mechanisnms of Impaired Wound Healing in Diabetes: Understanding the Role of Substance P and Mast Cells
Supervisor
 Farmácia (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/01/29 - 2024/01/30 Anual Meeting of Metabolism, Aging and Disease (2024/01/29 - 2024/01/30)
Meeting (Co-organisor)
 Universidade de Coimbra, Portugal
2023/11/19 - 2023/11/19 Diabetes Day Awareness (2023/11/19 - 2023/11/19)
Round table (President of the Organising Committee)
 Sociedade Portuguesa de Diabetologia, Portugal
2023/10/10 - 2023/10/13 International Anual congress from the European Tissue Regeneration Society. (2023/10/11 - 2023/10/13)
Congress (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2013/09/01 - 2019/08/01 CNC.IBILI Seminars (2013/01/01)
Seminar (Member of the Organising Committee)
 CNC.IBILI, Portugal
2018/03/23 - 2018/03/23 Organization of the “Biomedical Research Post-Doctoral Forum@UC: Overcoming Challenges in Scientific Careers” (2018/03/23 - 2018/03/23)
Workshop (Member of the Organising Committee)
 Faculty of Mecidine, University of Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/03/06 - 2020/03/08 Jury Committee for poster in Fundamental Investigation at the 16th Diabetes Portuguese Congress
Congress
 16th Diabetes Portuguese Congress
Sociedade Portuguesa de Diabetologia, Portugal
2015/12/17 - 2015/12/18 Chair in the session "Metabolism aging and disease" of the XIII CNC Annual Meeting
Conference
 XIII CNC Annual Meeting
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2014/03/06 - 2014/03/09 Chair in the session "basic research" at the “11th Diabetes Portuguese meeting”, Vilamoura, Portugal, 6-9 March, 2014.
Congress
 11th Diabetes Portuguese meeting
Sociedade Portuguesa de Diabetologia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/01/05 Dissecting the Mechanisms Governing Skin Wound Healing Induced by na Umbilical Cord Blood-Derived Product Sílvia Maria do Couto Rodrigues (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/11 UNRAVELLING THE MECHANISMS OF GHRELIN-MEDIATED REGULATION OF ADIPOSE TISSUE ANGIOGENESIS
(Thesis) Main arguer
 Daniela Rosendo da Silva (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/06/01 Can sulforaphane influence aging related pathways in the skin?
Supervisor
 Ana Rita Pinto Gomes (Other)
Universidade de Aveiro, Portugal
2016/02/16 Effect of high intensity training in inflammationand expression of genes from the metabolism of muscle and adipose tissue in rats fed with hiperlipidic diet
(Thesis) Main arguer
 Marcel Conrado de Freitas (Master)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Presidente Prudente, Brazil
2013/04/12 O estudo do controlo de qualidade das proteínas durante o envelhecimento utilizando um modelo animal transgénico que expressa CHIP no cristalino
(Thesis) Main arguer
 Raquel Soares Pereira (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2010/11/03 Avaliação do Efeito do Metilglioxal na resposta à Hipóxia em Cardiomiócitos
(Thesis) Main arguer
 Adriana Marques Toscato (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Association member

Society Organization name Role
2010/01/01 - Current Group of Investigation in Fundamental and Translational Research (GIFT)
2009/01/01 - Current Portuguese Society of Diabetologia
2009/01/01 - Current European Foundation for the Study of Diabetes (EFSD)
2004/01/01 - Current European Association for Vision and Eye Research (EVER)
2004/01/01 - Current Association for Research in Vision and Ophthalmology (ARVO)
2002/09/01 - Current Portuguese Biochemical Society, FEBS affiliate
2002/02/01 - Current Portuguese Neuroscience Society, FENS affiliate

Committee member

Activity description
Role 		Institution / Organization
2020/03 - Current Moderator of Session at 16th Portuguese Congress of Diabetes 2020
2015/01/01 - Current Committee member of registry of PostDocs@UC
Member
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02/01 - 2019/03/01 Postdoc representative at the CNC.IBILI consorcium
Member
 CNC.IBILI, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/03 - Current Moderator of Session at 17th Portuguese Congress of Diabetes 2021
2019/09/16 - 2019/09/20 Chairperson of a Poster Session at the 55th Annual Meeting of the European Association for the Study of Diabetes
Evaluator
 European Association for the Study of Diabetes, Germany
2018/01/19 - 2018/01/19 Abstract evaluator for the 2nd BEB/Bluepharma Award, BEB Day 2018, co-organized by the 14th Edition Students of the Doctoral Program of Experimental Biology and Biomedicine (PDBEB)
Evaluator
 Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2015/12/17 - 2015/12/18 Evaluation of oral communications at the CNC meeting, XIII CNC Annual Meeting Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2014/12/15 - 2014/12/16 Poster evaluation at the CNC meeting, XII CNC Annual Meeting
Evaluator
 Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2016/11/24 Interview for the article "Diabetes is not only a disease of the elderly" Jornal Universitário de Coimbra - A Cabra

Interview (tv / radio show)

Program Topic
2015/03/03 - 2016 Maratona da Saúde - Antena 1 Diabetic Foot Ulcers

Mentoring / Tutoring

Topic Student name
2016/09/01 - Current Antimicrobial peptides (AMP) and microRNA (miR) as synergistic therapy for wound healing Marija Petkovic
2016/09/01 - 2017/03/01 Mechanisms of skin wound healing Maria Terol Bertomeu
2009/09/01 - 2014/05/06 Cellular and molecular mechanisms of impaired wound healing in diabetes : understanding the role of substance P and mast cells Ana Luísa Alves Tellechea
2009/09/01 - 2013/11/03 Development of novel therapeutic approaches for wound healing in diabetes Liane Isabel Ferreira Moura
Distinctions

Award

2021 Luís Marques award.
Sociedade Portuguesa de Diabetologia, Portugal
2020 Investigation in Fundamental and Translational Group Award
Sociedade Portuguesa de Diabetologia, Portugal
2020 Pedro Eurico Award, honorable mention
Sociedade Portuguesa de Diabetologia, Portugal
2020 Bragança Parreira award
Sociedade Portuguesa de Diabetologia, Portugal
2019 SPD/Lilly travel award
Sociedade Portuguesa de Diabetologia, Portugal
2019 EASD travel award
European Association for the Study of Diabetes, Germany
2017 M. M. Almeida Ruas award, honorable mention.
Sociedade Portuguesa de Diabetologia, Portugal
2014 EASD travel award
European Association for the Study of Diabetes, Germany

Other distinction

2017 SPD/Lily travel award
Sociedade Portuguesa de Diabetologia, Portugal
2015 Postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2013 Pedro Eurico award
Sociedade Portuguesa de Diabetologia, Portugal
2012 Dr. M. M. Almeida Ruas Award
Sociedade Portuguesa de Diabetologia, Portugal
2012 EFSD/JDRF/Novo Nordisk European Programme in Type 1 Diabetes Research
European Foundation for the Study of Diabetes, Germany
2011 Disease Models and Mechanisms fellowship award
Company of Biologists, United Kingdom
2009 Albert Renold Fellowship award for Young Scientist
European Foundation for the Study of Diabetes, Germany
2009 Young Scientist fellowship award
Fundação Calouste Gulbenkian, Portugal
2009 Postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2008 Young Scientist Seminar
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal
2005 Best poster presented at the Retina and Vitreous sections Annual Meeting of the European Association for Vision and Eye Research
European Association for Vision and Eye Research, Belgium
2005 Best poster presented at the “15th Meeting of the European Association for the Study of Diabetes – Eye Complications Study Group (EASDec)”
European Association for the Study of Diabetes, Germany
2004 Best poster presented at the Retina, Cornea, Anatomy/Cell Biology, Uveitis and Vitreous sections
European Association for Vision and Eye Research, Belgium
2002 PRODEP
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2002 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2000 Honor Award for the best twelve undergraduate students of the Faculty of Sciences and Technology of the University of Coimbra
Universidade de Coimbra Departamento de Ciências da Vida, Portugal