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Beatriz Guedes holds a Bachelor's degree in Genetics and Biotechnology from the University of Trás-os-Montes and Alto Douro (UTAD) and a Master's degree in Clinical Laboratory Genetics from the Faculty of Medicine of the University of Coimbra (FMUC). Her master’s thesis was focused on exploring the role of a candidate microRNA in mitochondrial dysfunction and inflammatory responses in Parkinson’s Disease, under the supervision of Dr. Ana Raquel Esteves, at the Gut-Brain Axis Group from the Center for Neuroscience and Cell Biology (CNC-UC). Along with her master’s thesis, she also worked on another projects, leading to the publication, as co-author, of one book chapter and two original papers, currently published in Redox Biology and International Journal of Molecular Sciences. Furthermore, as a result of the work that she developed for her master’s thesis, she is first author of one review article published in Biomedicines and one original publication that is under preparation. Moreover, she was first author in a conference poster and in an oral communication in two international meetings, specifically "AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders" (Gothenburg, Sweden) and "57th Annual Scientific Meeting of the European Society for Clinical Investigation 2023" (Prague, Czech Republic). Additionally, she was first author of two poster communications in national meetings: "MAC- Mitochondria in Aging, Cancer, and Cell Death 2023" and “18th edition of the PDBEB symposium: (Not) Knowing What Comes Next: Tools for the Research of Tomorrow”. Moreover, she presented her work, as a speaker, at the 11th edition on signal transduction – SINAL 2024. Beatriz has been awarded a master’s research grant for the development of R&D activities within the project "Proof of concept for blood biomarkers of Alzheimer's Disease" at iBiMED (University of Aveiro) and worked as a researcher at the Advanced Therapies Group (CNC - UC-Biotech), on the "Reset Bone Ageing" project. Most recently, she was awarded a FCT PhD Fellowship.
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Identification

Personal identification

Full name
Beatriz Fernanda da Silva Guedes

Citation names

  • Guedes, B
  • Guedes, BFS

Author identifiers

Ciência ID
5D1B-56D5-983F
ORCID iD
0000-0002-8171-9062

Email addresses

  • beatrizfsguedes@gmail.com (Professional)
  • bguedes@cnc.uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2020 - 2023
Concluded
 Clinical Laboratory Genetics (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"The Role of a Candidate microRNA in Mitochondrial Dysfunction and Inflammatory Responses in vitro: Relevance to Parkinson’s Disease" (THESIS/DISSERTATION)
 17
2015 - 2020
Concluded
 Genetics and Biotechnology (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"A study in Drosophila melanogaster about the genotoxic impact of radiation emitted by cell phones" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/12/01 - 2024/05/31 Researcher (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/04 - 2023/07 Researcher (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
2021/09 - 2022/12 Research Trainee (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Projects

Grant

Designation Funders
2023/04 - 2023/07 Proof of concept for blood biomarkers of Alzheimer's Disease
CENTRO-01-0145-FEDER-181255
Researcher
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing

Other

Designation Funders
2023/12/01 - 2034/05/31 Reset Bone Ageing: Coating for orthopedic prostheses with the ability to increase bone tissue regeneration
POCI-01-0247-FEDER-069790
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 European Regional Development Fund
Ongoing
2021/09 - 2022/12 Microbiome-miRNAs axis in Parkinson's disease: involvement of mitochondria mediated inflammatory response
EXPL/MED-NEU/1515/2021
Master Student
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Candeias, E.; Nunes-Costa, D.; Magalhães, JD.; Esteves, AR.; Pereira-Santos, AR.; Marques, I.; Guedes, B.; Empadinhas, N.; Cardoso, SM.. "Neurotoxicity induced by ß-N-methylamino-L-alanine". In Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier Inc. Publisher., 2022.
    Published
Conference poster
  1. Beatriz Guedes; Sónia Duarte; Sandra Morais Cardoso; Ana Raquel Esteves. "Unveiling miR-486-5p role in Parkinson’s Disease: mitochondrial dysfunction and inflammation in vitro". Paper presented in 18th edition of the PDBEB symposium: (Not) Knowing What Comes Next: Tools for the Research of Tomorrow, 2024.
  2. Beatriz Guedes; Sónia Duarte; Sandra Morais Cardoso; Ana Raquel Esteves. "A gut miRNA targets cardiolipin synthase and affects mitochondrial function: relevance for Parkinson's disease". Paper presented in MAC- Mitochondria in Aging, Cancer and Cell Death, 2023.
  3. Beatriz Guedes; Sónia Duarte; Sandra Morais Cardoso; Ana Raquel Esteves. "Unmasking miRNA 486-5p role in Parkinson's disease: inflammation in the spotlight". Paper presented in AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (Gothenburg, Sweden), 2023.
Journal article
  1. Vicente-Zurdo, D; Brunetti, L; Piemontese, L; Guedes, B; Cardoso, SM; Chavarria, D; Borges, F; et al. "Rivastigmine-Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases". International Journal of Molecular Sciences (2023):
    Open access • Published • 10.3390/ijms24098312
  2. Guedes, BFS; Cardoso, SM; Esteves, AR. "The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson's Disease". Biomedicines (2023):
    Open access • Published • 10.3390/biomedicines11051349
  3. Esteves, AR; Silva, DF; Banha, D; Candeias, E; Guedes, B; Cardoso, SM. "LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease". Redox Biology (2023):
    Open access • Published • doi.org/10.1016/j.redox.2023.102714
Report
  1. Guedes, B. 2019. Bachelor's Internship: A study in Drosophila melanogaster about the genotoxic impact of radiation emitted by cell phones.
Thesis / Dissertation
  1. "The Role of a Candidate microRNA in Mitochondrial Dysfunction and Inflammatory Responses in vitro: Relevance to Parkinson's Disease". Master, Universidade de Coimbra Faculdade de Medicina, 2023.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/24 miR-486-5p impact on mitochondrial dysfunction and inflammation in vitro: relevance to Parkinson’s Disease (First Author and Presenting Author) 11th Edition on Signal Transduction – SINAL 2024
(Coimbra, Portugal)
2024/03/20 Does Parkinson's Disease Start in the Gut? The role of miR-486-5p in mitochondrial dysfunction and inflammatory responses: relevance to Parkinson's Disease (First Author and Presenting Author) Brain Gain: 2024 Edition
(Portugal)
2023/07/06 Uncovering a candidate gut miRNA role in mitochondrial dysfunction and inflammation: impact on Parkinson's disease. (First Author; Presenting Author - Ana Raquel Esteves) 57th Annual Scientific Meeting of the European Society for Clinical Investigation 2023
(Prague, Czech Republic)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/11/29 - 2022/11/29 Attended the Symposium: Genetic Tests in Context: people, families, society - 25 years of genetic tests at IBMC.
Symposium
 Genetic Tests in Context: people, families, society - 25 years of genetic tests at IBMC
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2022/05/02 - 2022/05/06 Attended the Proteomics Approaches in Life Sciences Course. Proteomics Approaches in Life Sciences Course
Biocant Associação de Transferência de Tecnologia, Portugal
2021/11/30 - 2021/11/30 Attended the V Symposium of the Portuguese Glial Network.
Symposium
 V Symposium of the Portuguese Glial Network
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2021/11/26 - 2021/11/26 Attended the 9th Neurogenetics Meeting - The genes of my eyes: Neurogenetic diseases with ophthalmic manifestations.
Meeting
 The genes of my eyes: Neurogenetic diseases with ophthalmic manifestations
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/10/11 - 2021/10/13 Attended the 3rd NMS Symposium about Chronic Diseases and Translational Science.
Symposium
 3rd NMS Symposium: Chronic Diseases and Translational Science
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/07/07 - 2021/07/07 Attended the 2nd GenomePT Symposium.
Symposium
 2nd GenomePT Symposium
Biocant Associação de Transferência de Tecnologia, Portugal

Universidade de Aveiro Instituto de Biomedicina, Portugal