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Pedro Eduardo Mendes Ferreira. Completed the Licenciatura in Engenharia Biotecnológica in 2004 by Instituto Politécnico de Bragança, Bacharelato in Engenharia Biotecnológica in 2002 by Instituto Politécnico de Bragança, Doktor (PhD) in Doutoramento in 2010 by Karolinska Institutet and Postgraduate Certificate in Bioentrepreneurship in 2010 by Stockholms Universitet Foretagsekonomiska Institutionen. Is Auxiliary Researcher in Universidade do Minho. Published 50 articles in journals. Has 2 patent(s) registered. Organized 1 event(s). Participated in 5 event(s). Supervised 3 PhD thesis(es) e co-supervised 1. Supervised 3 MSc dissertation(s) e co-supervised 1. Supervised 1 work(s) of course completion of LSc/BSc. Has received 20 awards and/or honors. Participates and/or participated as Principal investigator in 8 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences. In their professional activities interacted with 231 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Malaria; Acoustics; Integrated optics; Microdevice; Engenharia de Tecidos e Medicina Regenerativa; Biomateriais e Nanomedicina; Biomedicina e Ciências Translacionais; Ciências Clinicas; Biomaterials; Tissue Engineering and Regenerative Medicine; biodegradables and biomimetics; Microbiology and Immunology of Infection; Neurosciences; Aging and Surgical Sciences; malaria; molecular biology; molecular therapy; translational research; infection; cerebral malaria; combination therapy; drug resistance; drug target; Tissue Engineering and Regenerative Medicina; Biomaterials and Nanomedicine; Biomedicine and Translational Sciences; Clinical Sciences; Antimalarial; Rastreio de alto rendimento para fármacos; Biosensores; Resistência a fármacos; MALARIA; VACCINE; DRUG RESISTANCE; SINGLE-CELL OMICS; GENOME EDITING; N/A; Chloroquine-resistance; Malaria parasites; Artemether-lumefantrine; Antimalarial-drugs; Pfmdr1 mutations; Amodiaquine; Fitness; Sensitivity; Artesunate; Selection; .
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Identification

Personal identification

Full name
Pedro Eduardo Mendes Ferreira

Citation names

  • Ferreira, PE

Author identifiers

Ciência ID
5E15-DD6D-50E6
ORCID iD
0000-0002-2682-7722

Knowledge fields

  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Swedish Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2009 - 2010
Concluded
 Bioentrepreneurship (Postgraduate Certificate)
Major in Bioentrepreneurship
Stockholms Universitet Foretagsekonomiska Institutionen, Sweden
2010
Concluded
 Doutoramento (Doktor (PhD))
Karolinska Institutet, Sweden
"Molecular basis for the mechanism of action and resistance to artemisinin combination therapy in Plasmodium falciparum" (THESIS/DISSERTATION)
 Pass
2004
Concluded
 Engenharia Biotecnológica (Licenciatura)
Instituto Politécnico de Bragança, Portugal
"Farmacogenética na populacão de Zanzibar" (THESIS/DISSERTATION)
 14
2002
Concluded
 Engenharia Biotecnológica (Bacharelato)
Instituto Politécnico de Bragança, Portugal
"Caracterização molecular de duas variedades de Castanea sativa longal e judia" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2016 - Current Auxiliary Researcher (Research) Universidade do Minho, Portugal
School of Medicine, University of Minho, Portugal
2013 - 2015 Contracted Researcher (Research) Nanyang Technological University, Singapore
2011 - 2013 Postdoc (Research) Institute of Tropical Medicine Nagasaki University, Japan

Positions / Appointments

Category
Host institution 		Employer
2014/04/11 - 2015/04/11 Researcher Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2007 - 2013 Researcher Instituto de Biotecnologia e Bioengenharia, Portugal
Instituto de Biotecnologia e Bioengenharia, Portugal
Projects

Grant

Designation Funders
2022/05/01 - Current Mechanisms of action and resistance to the antimalarial Purydrazide
2766
Principal investigator
Ongoing
2022 - Current New pharmaceutical compounds, methods and uses thereof
PTDC/SAU-PAR/2766/2021
2015/12/01 - 2018/12/31 Next generation molecular biology in infectious diseases
SFRH/BPD/110231/2015
 Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2013 YCnano genetically encoded sensors for malaria
1
Principal investigator
Nagasaki Daigaku Nettai Igaku Kenkyujo, Japan
 Japan Society for the Promotion of Science Stockholm
Concluded
2007/01/01 - 2010/12/31 CALCIUM OSCILLATIONS IN HUMAN MALARIA PARASITE: IMPLICATIONS FOR THE MECHANISM OF ACTION OF ARTEMISININ AGAINST PLASMODIUM FALCIPARUM
SFRH/BD/28368/2006
Karolinska Institutet, Sweden
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018 - Current MULTIMAL- A point-of-care device for non-invasive multiplexed diagnosis of malaria
MULTIMAL
Principal investigator
EU Framework Programme for Research and Innovation Euratom, Belgium
 EU Framework Programme for Research and Innovation Euratom
2021/07/01 - 2027/06/30 Next-generation of drugs and treatments for malaria
2020.02226.CEECIND/CP1600/CT0014
10.54499/2020.02226.CEECIND/CP1600/CT0014
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
LA/P/0050/2020
10.54499/LA/P/0050/2020
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/05/01 - 2025/04/30 Mechanisms of action and resistance to the antimalarial Purydrazide
PTDC/SAU-PAR/2766/2021
10.54499/PTDC/SAU-PAR/2766/2021
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

BnML Behavioral and Molecular Lab Lda, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/12/01 - 2022/12/01 Unveilling molecular adaptation mechanisms in human malaria parasites
IF/00143/2015/CP1294/CT0001
Principal investigator
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/05/31 Innovative non-invasive opto-acoustic microdevice for malaria diagnosis
PTDC/EEI-EEE/28178/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2022/04/30 MalPharm - A genetic sensors-based highthroughput screening platform for antimalarial development
PTDC/SAU-PAR/28066/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/09 - 2021/09 MalPharm - A genetic sensors-based high-throughput screening platform for antimalarial development
028066
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2018/07/01 - 2021/07/01 Inovative non-invasive opto-acoustic microdevice for malaria diagnosis
PTDC/EEI-EEE/28178/2017
Researcher
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
2018/07/01 - 2021/06/30 Innovative non-invasive opto-acoustic microdevice for malaria diagnosis
PTDC/EEI-EEE/28178/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/12/01 - 2021/06/30 Untitled
IF/00143/2015/CP1294/CT0001
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/12/01 - 2021/06/30 Unveilling molecular adaptation mechanisms in human malaria parasites
IF/00143/2015/CP1294/CT0001
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/09 - 2020/09 Implications of hemoglobin catabolism in antimalarial resistance
126648
Principal investigator
European Society of Clinical Microbiology and Infectious Diseases
Ongoing
2019/04 - 2020/04 A point-of-care device for non-invasive multiplexed diagnosis of malaria MULTIMAL
1
Principal investigator
Universidade do Minho, Portugal
 Laboratório Associado ICVS 3B's
Concluded
2019/01/01 - 2019/12/31 ICVS/3B¿s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2013 A new molecular surveillance system for leishmaniasis
2011
Principal investigator
UBS Optimus Foundation, Switzerland
 UBS Optimus Foundation
Outputs

Publications

Conference poster
  1. Ferreira, Pedro; Gonçalves, Adriana F.; Lima-Pinheiro, Ana. Corresponding author: Ferreira, Pedro. "Proteasome mutation promotes resistance to artemisinin in Plasmodium falciparum". Paper presented in Malaysian Society of Parasitology & Tropical Medicine, 2024.
  2. Ferreira, Pedro; Gonçalves, Adriana F.; Lima-Pinheiro, Ana. Corresponding author: Ferreira, Pedro. "Molecular mechanisms for artemisinin-piperaquine resistance in Plasmodium falciparum". Paper presented in Malaysian Society of Parasitology & Tropical Medicine, 2024.
  3. Silva, Miguel; Calçada, C; Baptista, V; Silva-Pedrosa, R; Granja, D; Fidock, DA; Ferreira, PE; Veiga, MI. "Disclosure of na influx ABC transporter protein in the protozoan malaria parasite". Paper presented in Molecular Approaches to Malaria Conference 2020 - MAM2020, 2020.
  4. Calçada, C; Silva, Miguel; Cruz, T; Baptista, V; Ferreira, PE; Cruz Silva, MM; Veiga, MI. "Oxysterols: synthesis and antimalarial drug potency". Paper presented in Molecular Approaches to Malaria Conference 2020 - MAM2020, 2020.
  5. Calçada, C; Silva, Miguel; Baptista, Vitória; Teixeira, M; Pinheiro, A; Silva-Pedrosa, R; Granja, D; et al. "Expansion of a Plasmodium falciparum specific pfmdr1 in Southeast Asia with increased transport kinetics". Paper presented in Molecular Approaches to Malaria Conference 2020 - MAM2020, 2020.
  6. Dahlstrom, Sabina; Ferreira, Pedro; Wiklund, Lisa; Veiga, Maria Isabel; Sedighi, Nazli; Martensson, Andreas; Kaneko, Akira; et al. "The role of Plasmodium falciparum multidrug resistance-associated protein 1 (pfmrp1) in development of resistance to artemisinin-based combination therapies (ACTs)". Paper presented in 3rd Molecular Approaches to Malaria Meeting (MAM 2008), 2008.
  7. Dahlstrom, Sabina; Veiga, Maria Isabel; Ferreira, Pedro; Martensson, Andreas; Kaneko, Akira; Andersson, Bjorn; Bjorkman, Anders; Gil, Jose Pedro. "The sarco/endoplasmic reticulum Ca2+-ATPase orthologue of Plasmodium falciparum (PfATP6) harbours high SNP diversity". Paper presented in 3rd Molecular Approaches to Malaria Meeting (MAM 2008), 2008.
Journal article
  1. Gonçalves, Adriana F.; Lima-Pinheiro, Ana; Ferreira, Pedro E.. "Ubiquitin-proteasome system in Plasmodium: a potential antimalarial target to overcome resistance – a systematic review". Frontiers in Medicine 11 (2024): http://dx.doi.org/10.3389/fmed.2024.1441352.
    10.3389/fmed.2024.1441352
  2. Cassiano, Gustavo Capatti; Martinelli, Axel; Mottin, Melina; Neves, Bruno Junior; Andrade, Carolina Horta; Ferreira, Pedro Eduardo; Cravo, Pedro. "Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination". Frontiers in Cellular and Infection Microbiology 14 (2024): http://dx.doi.org/10.3389/fcimb.2024.1353057.
    10.3389/fcimb.2024.1353057
  3. Gonçalves, Adriana F.; Lima-Pinheiro, Ana; Teixeira, Miguel; Cassiano, Gustavo Capatti; Cravo, Pedro; Ferreira, Pedro E.. "Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin". Frontiers in Cellular and Infection Microbiology 14 (2024): http://dx.doi.org/10.3389/fcimb.2024.1342856.
    10.3389/fcimb.2024.1342856
  4. Rita Silva-Pedrosa; António José Salgado; Pedro Eduardo Ferreira. "Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems". Cells 12 6 (2023): 930-930. http://dx.doi.org/10.3390/cells12060930.
    10.3390/cells12060930
  5. Ana Pedrosa; Jonas de Oliveira Campos; Aline Marie Fernandes; Miguel Silva; Carla Calçada; Ana Marote; Martinho O; et al. "Cerebral Malaria Model Applying Human Brain Organoids". Cells (2023): https://www.mdpi.com/2073-4409/12/7/984.
    10.3390/cells12070984
  6. Ferreira PE. "Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast". Antimicrobial Agents and Chemotherapy 66 5 (2022): http://dx.doi.org/10.1128/aac.02079-21.
    10.1128/aac.02079-21
  7. Calçada, Carla; Silva, Miguel; Baptista, Vitória; Thathy, Vandana; Silva-Pedrosa, Rita; Granja, Diana; Ferreira, Pedro Eduardo; et al. "Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport". mBio 11 6 (2020): http://dx.doi.org/10.1128/mbio.02093-20.
    10.1128/mbio.02093-20
  8. Silva, Miguel; Calçada, Carla; Teixeira, Miguel; Veiga, Maria Isabel; Ferreira, Pedro Eduardo. "Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum". The Lancet Infectious Diseases 20 1 (2020): 26-27. http://dx.doi.org/10.1016/s1473-3099(19)30689-9.
    10.1016/s1473-3099(19)30689-9
  9. Ferreira, Pedro. "Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy". Journal of Antimicrobial Chemotherapy (2019):
    https://doi.org/10.1093/jac/dkz098
  10. Silva, M.; Ferreira, P.E.; Otienoburu, S.D.; Calcada, C.; Ngasala, B.; Björkman, A.; Mårtensson, A.; Gil, J.P.; Veiga, M.I.. "Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy". Journal of Antimicrobial Chemotherapy 74 7 (2019): 1890-1893. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068495935&partnerID=MN8TOARS.
    10.1093/jac/dkz098
  11. Ferreira, Pedro. "Dosage of single low-dose primaquine to stop malaria transmission". Journal of Infectious Diseases (2018):
    DOI: 10.1093/infdis/jiy108
  12. Ferreira, Pedro. "Plasmodium falciparum Plasmepsin 2 Duplications, West Africa". Emerging Infectious Diseases 24 8 (2018): 1591-1591.
    10.3201/eid2408.180370
  13. Cruz, M.; Sánchez, I.M.; Diaz, J.; Cuevas, F.; Silva, M.; Disla, M.; Ferreira, P.E.; Veiga, M.I.. "Dosage of single low-dose primaquine to stop malaria transmission". Journal of Infectious Diseases 217 11 (2018): 1849-1850. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050482968&partnerID=MN8TOARS.
    10.1093/infdis/jiy108
  14. Manu Vanaerschot; Leonardo Lucantoni; Tao Li; Jill M. Combrinck; Andrea Ruecker; T. R. Santha Kumar; Kelly Rubiano; et al. "Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity". Nature Microbiology (2017): https://doi.org/10.1038/s41564-017-0007-4.
    10.1038/s41564-017-0007-4
  15. Kishor Pandey; Pedro E. Ferreira; Takeshi Ishikawa; Takeharu Nagai; Osamu Kaneko; Kazuhide Yahata. "Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor". Sci. Rep. 6 (2016): 23454-23454. http://dx.doi.org/10.1038/srep23454.
    10.1038/srep23454
  16. Mok, Sachel; Ashley, Elizabeth A; Ferreira, Pedro E; Zhu, Lei; Lin, Zhaoting; Yeo, Tomas; Chotivanich, Kesinee; et al. "Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance". Science 347 6220 (2015): 431-435. http://www.sciencemag.org/content/347/6220/431.short.
    10.1126/science.1260403
  17. Bozdech, Zbynek; Ferreira, Pedro E; Mok, Sachel. "A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum". Trends in Parasitology (2015):
    10.1016/j.pt.2015.06.004
  18. Abkallo, Hussein M; Liu, Weimin; Hokama, Sarina; Ferreira, Pedro E; Nakazawa, Shusuke; Maeno, Yoshimasa; Quang, Nguyen T; et al. "DNA from pre-erythrocytic stage malaria parasites is detectable by PCR in the faeces and blood of hosts". International journal for parasitology 44 7 (2014): 467-473.
    10.1016/j.ijpara.2014.03.002
  19. Jovel, Irina Tatiana; Ferreira, Pedro Eduardo; Veiga, Maria Isabel; Malmberg, Maja; M{\aa. "Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms". Infection, Genetics and Evolution 24 (2014): 111-115.
    10.1016/j.meegid.2014.03.004
  20. Pandey, Kishor; Pandey, Basu Dev; Mallik, Arun Kumar; Acharya, Jyoti; Kato, Kentaro; Kaneko, Osamu; Ferreira, Pedro Eduardo. "A new molecular surveillance system for leishmaniasis". The American journal of tropical medicine and hygiene 90 6 (2014): 1082-1086.
    10.4269/ajtmh.13-0329
  21. Veiga, Maria Isabel; Os{\'o. "Complex polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 gene and its contribution to antimalarial response". Antimicrobial agents and chemotherapy 58 12 (2014): 7390-7397.
    10.1128/AAC.03337-14
  22. Ferreira, Pedro. "Artemisinin resistance in Plasmodium falciparum". The Lancet Infectious Diseases 14 6 (2014): 450-451.
    https://doi.org/10.1016/S1473-3099(14)70706-6
  23. Lun, Z.-R.; Ferreira, P.E.; Fu, L.-C.. "Artemisinin resistance in Plasmodium falciparum". The Lancet Infectious Diseases 14 6 (2014): 450-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900870888&partnerID=MN8TOARS.
    10.1016/S1473-3099(14)70706-6
  24. Fröberg, Gabrielle; Ferreira, Pedro Eduardo; Mårtensson, Andreas; Ali, Abdullah; Björkman, Anders; Gil, José Pedro. "Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro". Antimicrobial agents and chemotherapy 57 2 (2013): 887-892.
    10.1128/AAC.00950-12
  25. Ferreira, Pedro Eduardo; Culleton, Richard; Gil, Jose Pedro; Meshnick, Steven Richard. "Artemisinin resistance in< i> Plasmodium falciparum: what is it really?". Trends in Parasitology (2013):
    10.1016/j.pt.2013.05.002
  26. Malmberg, Maja; Ferreira, Pedro E.; Tarning, Joel; Ursing, Johan; Ngasala, Billy; Björkman, Anders; Mårtensson, Andreas; Gil, José P.. "Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms". Journal of Infectious Diseases 207 5 (2013): 842-847.
    10.1093/infdis/jis747
  27. Morris, U.; Aydin-Schmidt, B.; Shakely, D.; Mårtensson, A.; Jörnhagen, L.; Ali, A.S.; Msellem, M.I.; et al. "Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability". Malaria Journal 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875042567&partnerID=MN8TOARS.
    10.1186/1475-2875-12-106
  28. Hunja, Carol W.; Unger, Holger; Ferreira, Pedro E.; Lumsden, Richard; Morris, Sheila; Aman, Rashid; Alexander, Claire; Mita, Toshihiro; Culleton, Richard. "Travellers as sentinels: Assaying the worldwide distribution of polymorphisms associated with artemisinin combination therapy resistance in< i> Plasmodium falciparum using malaria cases imported into Scotland". International journal for parasitology 43 11 (2013): 885-889.
    10.1016/j.ijpara.2013.07.001
  29. Malmberg, M.; Ngasala, B.; Ferreira, P.E.; Larsson, E.; Jovel, I.; Hjalmarsson, A.; Petzold, M.; et al. "Temporal trends of molecular markers associated with artemether- lumefantrine tolerance/resistance in Bagamoyo district, Tanzania". Malaria Journal 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875047883&partnerID=MN8TOARS.
    10.1186/1475-2875-12-103
  30. Froberg, Gabrielle; PE, Ferreira; Martensson, Andreas; Ali, Abdullah; Bjorkman, Anders; Gil, J. P.. "Assessing the cost-benefit effect of a plasmodium falciparum drug resistance mutation on parasite growth In vitro". (2013): http://hdl.handle.net/10400.1/11288.
    10.1128/AAC.00950-12
  31. Veiga, M. I.; Ferreira, P. E.; Malmberg, M.; Jornhagen, L.; Bjorkman, A.; Nosten, F.; Gil, J. P.. "pfmdr1 Amplification Is Related to Increased Plasmodium falciparum In Vitro Sensitivity to the Bisquinoline Piperaquine". Antimicrobial Agents and Chemotherapy 56 7 (2012): 3615-3619.
    10.1128/aac.06350-11
  32. Ferreira, P. E.; Culleton, R.. "Dynamics of Plasmodium falciparum Selection After Artemether-Lumefantrine Treatment in Africa". Journal of Infectious Diseases 205 9 (2012): 1473-U155.
    10.1093/infdis/jis227
  33. Culleton, R.L.; Ferreira, P.E.. "Duffy phenotype and plasmodium vivax infections in humans and apes, Africa". Emerging Infectious Diseases 18 10 (2012): 1704-1705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866535378&partnerID=MN8TOARS.
    10.3201/eid1810.120120
  34. Veiga, M.I.; Ferreira, P.E.; Malmberg, M.; Jörnhagen, L.; Björkman, A.; Nosten, F.; Gil, J.P.. "pfmdr1 amplification is related to increased Plasmodium falciparum in vitro sensitivity to the bisquinoline piperaquine". Antimicrobial Agents and Chemotherapy 56 7 (2012): 3615-3619. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862538598&partnerID=MN8TOARS.
    10.1128/AAC.06350-11
  35. Ngasala, B. E.; Malmberg, M.; Carlsson, A. M.; Ferreira, P. E.; Petzold, M. G.; Blessborn, D.; Bergqvist, Y.; et al. "Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study". Malaria Journal 10 (2011):
    10.1186/1475-2875-10-64
  36. Jovel, I. T.; Mejia, R. E.; Banegas, E.; Piedade, R.; Alger, J.; Fontecha, G.; Ferreira, P. E.; et al. "Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America". Malaria Journal 10 (2011):
    10.1186/1475-2875-10-376
  37. Ngasala, B. E.; Malmberg, M.; Carlsson, A. M.; Ferreira, P. E.; Petzold, M. G.; Blessborn, D.; Bergqvist, Y.; et al. "Efficacy and Effectiveness of Artemether-Lumefantrine after Initial and Repeated Treatment in Children < 5 Years of Age with Acute Uncomplicated Plasmodium falciparum Malaria in Rural Tanzania: A Randomized Trial". Clinical Infectious Diseases 52 7 (2011): 873-882.
    10.1093/cid/cir066
  38. Veiga, M. I.; Ferreira, P. E.; Jornhagen, L.; Malmberg, M.; Kone, A.; Schmidt, B. A.; Petzold, M.; et al. "Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance". Plos One 6 5 (2011):
    10.1371/journal.pone.0020212
  39. Ferreira, P. E.; Holmgren, G.; Veiga, M. I.; Uhlen, P.; Kaneko, A.; Gil, J. P.. "PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms". Plos One 6 9 (2011):
    10.1371/journal.pone.0023875
  40. Veiga, M. I.; Ferreira, P. E.; Schmidt, B. A.; Ribacke, U.; Bjorkman, A.; Tichopad, A.; Gil, J. P.. "Antimalarial Exposure Delays Plasmodium falciparum Intra-Erythrocytic Cycle and Drives Drug Transporter Genes Expression". Plos One 5 8 (2010):
    10.1371/journal.pone.0012408
  41. Dahlstrom, S.; Ferreira, P. E.; Veiga, M. I.; Sedighi, N.; Wiklund, L.; Martensson, A.; Farnert, A.; et al. "Plasmodium falciparum Multidrug Resistance Protein 1 and Artemisinin-Based Combination Therapy in Africa". Journal of Infectious Diseases 200 9 (2009): 1456-1464.
    10.1086/606009
  42. Veiga, M. I.; Asimus, S.; Ferreira, P. E.; Martins, J. P.; Cavaco, I.; Ribeiro, V.; Hai, T. N.; et al. "Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam". European Journal of Clinical Pharmacology 65 4 (2009): 355-363.
    10.1007/s00228-008-0573-8
  43. Ferreira, P.E.; Veiga, M.I.; Cavaco, I.; Martins, J.P.; Andersson, B.; Mushin, S.; Ali, A.S.; et al. "Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, east Africa". Therapeutic Drug Monitoring 30 1 (2008): 10-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549176303&partnerID=MN8TOARS.
    10.1097/FTD.0b013e31815e93c6
  44. Dahlstrom, S.; Veiga, M. I.; Ferreira, P.; Martensson, A.; Kaneko, A.; Andersson, B.; Bjorkman, A.; Gil, J. P.. "Diversity of the sarco/endoplasmic reticulum Ca2+-ATPase orthologue of Plasmodium falciparum (PfATP6)". Infection Genetics and Evolution 8 3 (2008): 340-345.
    10.1016/j.meegid.2008.02.002
  45. Ferreira, P. E.; Cavaco, I.; Gil, J. P.. "Pharmacogenetic tools for malaria and TB in the Developing World". Personalized Medicine 5 6 (2008): 627-639.
    10.2217/17410541.5.6.627
  46. Cavaco, I.; Asimus, S.; Peyrard-Janvid, M.; Ferreira, P. E.; Veiga, M. I.; Hai, T. N.; Ribeiro, V.; Ashton, M.; Gil, J. P.. "The Vietnamese Khin population harbors particular N-acetyltransferase 2 allele frequencies". Clinical Chemistry 53 11 (2007): 1977-1979.
    10.1373/clinchem.200.7.092684
  47. Sisowath, C.; Ferreira, P. E.; Bustamante, L. Y.; Dahlstrom, S.; Martensson, A.; Bjorkman, A.; Krishna, S.; Gil, J. P.. "The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa". Tropical Medicine & International Health 12 6 (2007): 736-742.
    10.1111/j.1365-3156.2007.01843.x
  48. Cavaco, I.; Asimus, S.; Peyrard-Janvid, M.; Ferreira, P.E.; Veiga, M.I.; Hai, T.N.; Ribeiro, V.; Ashton, M.; Gil, J.P.. "The Vietnamese khin population harbors particular N-acetyltransferase 2 allele frequencies [2]". Clinical Chemistry 53 11 (2007): 1977-1979. http://www.scopus.com/inward/record.url?eid=2-s2.0-35649010335&partnerID=MN8TOARS.
    10.1373/clinchem.2007.092684
  49. Holmgren, G.; Gil, J. P.; Ferreira, P. M.; Veiga, M. I.; Obonyo, C. O.; Bjorkman, A.. "Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y". Infection Genetics and Evolution 6 4 (2006): 309-314.
    10.1016/j.meegid.2005.09.001
  50. Veiga, M.I.; Ferreira, P.E.; Björkman, A.; Gil, J.P.. "Multiplex PCR-RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum". Molecular and Cellular Probes 20 2 (2006): 100-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644774433&partnerID=MN8TOARS.
    10.1016/j.mcp.2005.10.003
Preprint
  1. Silva, Miguel; Calçada, Carla; Osório, Nuno S.; Baptista, Vitoria; Thathy, Vandana; Teixeira, Miguel; Reid, Adam; et al. "The Plasmodium falciparum protein PfMRP1 functions as an influx ABC transporter". 2022. http://dx.doi.org/10.21203/rs.3.rs-1210682/v1.
    10.21203/rs.3.rs-1210682/v1

Intellectual property

Patent
  1. GONÇALVES CARVALHO, Maria Alice MENDES FERREIRA, Pedro Eduardo MEIRINHO, Sofia Gabriel CORDEIRO DA SILVA, Anabela PINTO. 2023. "PYRIMIDO[5,4-D]PYRIMIDINE-BASED COMPOUNDS, METHODS AND USES THEREOF".
    Granted/Issued
  2. Ferreira, Pedro. 2021. "GRAPHENE-BASED MALARIA SENSOR, METHODS AND USES THEREOF".
Provisional application for patent
  1. 2020. "ANTIMALARIAL AGENT, METHODS AND USES THEREOF".
    Disclosed

Other

Other output
  1. Gender Influence on Asymptomatic Malaria Diagnosis. 2021. Sofia Meirinho; Matilde Gomes; Ana Campos; Duarte Baptista; Alberta Baptista; Gil Sequeira; Pedro Eduardo Ferreira. https://doi.org/10.21203/rs.3.rs-672926/v1.
    10.21203/rs.3.rs-672926/v1
Spin-off company
  1. 2021. IPLEXMED. Medical devices. www.iplexmed.com.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07/20 Cerebral malaria model applying human brain organoids 21st International Congress for Tropical Medicine and Malaria (ICTMM 2024)
Malaysian Society of Parasitology & Tropical Medicine (Kuching, Malaysia, Malaysia)
2023/04/21 Malaria, a social disease
Rotary Club (Viana do Castelo, Portugal)
2018/11/13 Piperaquine resistance in malaria parasites KI-Japan Joint Seminar “Malaria research: Innovations and Global Malaria Eradication”
The Japan Society for the Promotion of Science (JSPS) (Stockholm, Sweden)
2018/08/23 PfMRP1 is a drug / metabolite importer in Plasmodium falciparu 14th International Congress of Parasitology (ICOPA 2018)
Korean Society for Parasitology and Tropical Medicine (KSPTM) (Daegu, South Korea)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/07/01 - 2023/12/12 The role of plasmepsin 2/3 gene amplifications in the adaptation of the digestive vacuole on Plasmodium falciparum antimalarial resistance
Supervisor
 Medical Sciences (Master)
Laboratório Associado ICVS 3B's, Portugal
2018/01 - 2023/04 Cerebral malaria: Plasmodium falciparum effect on human brain microvascular endothelial cells and brain organoids
Supervisor
 Cerebral Infection (PhD)
Massachusetts Institute of Technology MIT Portugal Program, Portugal

Laboratório Associado ICVS 3B's, Portugal
2017/03 - 2022/09 ABC transporters in Plasmodium falciparum
Supervisor of Miguel João Ferreira da Silva
 PARASITOLOGY (PhD)
Laboratório Associado ICVS 3B's, Portugal
2019/09 - 2022/04 Applying genetically sensors for malaria research
Supervisor of Ana Rita Pinheiro
 Malaria research (Master)
Laboratório Associado ICVS 3B's, Portugal
2019/09 - 2022/03 Desenvolvimento de uma abordagem molecular para estudar o proteossoma 26S no Plasmodium falciparum
Supervisor of Adriana Faria
 Molecular parasitology (Master)
Laboratório Associado ICVS 3B's, Portugal
2019/03/29 - 2020/03/29 Genome editing tools for Plasmodium falciparum
Supervisor
 genome editing (PhD)
Laboratório Associado ICVS 3B's, Portugal
2016/04/01 - 2016/07/01 Estudos na interação molecular hospedeiro-parasita na malária
Supervisor of Ana Rita Pinheiro
 Parasitology (Degree)
Laboratório Associado ICVS 3B's, Portugal
2009 - 2014/10/24 Master thesis, Aspects of molecular markers in drug resistant malaria
Co-supervisor of Irina Tatiana Jovel Quiñonez Dalmau
 Medical Sciences (Master)
Karolinska Institutet, Sweden
2009 - 2013/01/18 PhD thesis, The role of molecular markers in emerging artemether-lumefantrine resistant Plasmodium falciparum
Co-supervisor of Maja Malmberg
 PhD Student (PhD)
Karolinska Institutet, Sweden

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2010/09/01 - 2010/09/03 1st Nordic Malaria Conference (2010/09/01 - 2010/09/03)
Conference (Member of the Organising Committee)
 Karolinska Institutet, Sweden

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/11/28 - Current Science social dissemination. Participation on the Week of Science.
Conference
ProEnsino, Portugal
2018/11/13 - Current In the year 2018, Japan and Sweden will celebrated 150 years of diplomatic relations with the Sweden-Japan joint seminar “Malaria research: innovations and global malaria eradication”
Meeting
 KI-Japan joint seminar “Malaria research: innovations and global malaria eradication”
Japan Society for the Promotion of Science Stockholm, Sweden
2020/10/26 - 2020/10/28 Presentation of resesearch work in cerebral malaria applying cerebral organoids
Other
 Cerebral Organoids Course and Symposium Cambridge, GB
Federation of European Neuroscience Societies, Belgium
2019/11/13 - 2019/11/13 14th malaria Meeting, Berhard Nocht Institute
Conference
 14th malaria Meeting
Berhard-Nocht-Institut, Germany
2010 - 2010 ABC2010 covers all basic and applied aspects of ABC proteins, both in normal and cancer cells, as well as their important roles in genetic diseases as well as drug resistance phenomena in cancer or microbial systems.
Conference
 FEBS Special Meeting: "ATP Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases"
Federation of European Biochemical Societies, United Kingdom
2008/02/03 - 2008/02/07 MAM is one of the most prestigious molecular malaria congress worldwide
Congress
 Molecular approaches to malaria: MAM
The Walter and Eliza Hall Institute of Medical Research, Australia

Association member

Society Organization name Role
2018 - Current European high-capacity screening network - PT-OPENSCREEN consortium Member
2015 - Current European Society of Clinical Microbiology and Infectious Diseases ESCMID Member

Committee member

Activity description
Role 		Institution / Organization
2018 - Current Member of the Scientific Board of the Microbiology and Infection Research Domain at ICVS, School of Medicine, University of Minho
Member
 Laboratório Associado ICVS 3B's, Portugal
2008 - 2010 Swedish Malaria Network
Member

Consulting

Activity description Institution / Organization
2024/11 - Current Expert project evaluator for UK Research and Innovation (UKRI) funding agency UK Research and Innovation, United Kingdom
2021 - Current Guest Editor of MDPI for International Journal of Molecular Sciences and Biology MDPI AG, Switzerland
2013 - 2013 Consultancy for the Asian-Pacific references for UBS UBS Optimus Foundation, Union of Swiss Banks, , Switzerland

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/11 - Current Fundamentals in Neurosciences (Pós-Graduação) School of Medicine, University of Minho, Portugal
2024/11 - Current Fundamentals in Immunology. Classes of Translational research in immunology and infectious diseases School of Medicine, University of Minho, Portugal
2024/10 - Current Fundamentals in Neurosciences (Pós-Graduação) School of Medicine, University of Minho, Portugal
2019 - Current Bioinformatics (Curso de doutoramento (conclusão de unidades curriculares)) Laboratório Associado ICVS 3B's, Portugal
2018 - Current Nano-Bioengineering for Medicine (Curso de doutoramento (conclusão de unidades curriculares)) Laboratório Associado ICVS 3B's, Portugal
2016 - Current Master in Tropical Medicine Citometry (Curso de doutoramento (conclusão de unidades curriculares)) Laboratório Associado ICVS 3B's, Portugal
2016 - Current Fundaments in Immunology (Curso de doutoramento (conclusão de unidades curriculares))
2009 - Current Malaria and Genomes (Doktor (PhD)) Karolinska Institutet, Sweden
2023/03/13 - 2023/03/13 Finding solutions in a dish: advanced human in vitro modeling approaches for fundamental and translational researc (Pós-Graduação) School of Medicine, University of Minho, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023 Development of the first human cerebral model to study cerebral malaria in vitro Jornal de Noticias
2019/05/30 Cientistas desenvolvem em Portugal teste rápido e barato para detetar malária Observador
2017/08/16 Investigadores demonstram eficácia de fármaco contra parasita que transmite a malária Diário de Noticias
2016/08/22 Interview regarding my return to Portugal to implement my research group Jornal de Noticias
2010/09/10 Experience regarding PhD studies abroad Jornal de Noticias

Interview (tv / radio show)

Program Topic
2019/06/18 - Current Mentes que brilham Malaria
2021/02/16 - 2021/02/16 90 segundos de ciência Malaria research programa at ICVS

Journal scientific committee

Journal title (ISSN) Publisher
2020/03 - Current International Journal of Infectious Diseases and Therapy (2578-9651) Science Publishing Group
2013 - Current Tropical Medicine and Health Journal (1349-4147)

Mentoring / Tutoring

Topic Student name
2019 - Current Postdoc Supervision, Sofia Meirinho
2020/03/01 - 2020/06/01 Carolina Silva
2013 - 2013 Postdoc supervision, Maja Malmberg
Distinctions

Award

2022 Born of Knowledge award (Bfk)
Altice International Innovation Award, Portugal
2022 Startup Braga 7th Acceleration program
Startup Braga, Portugal
2021 Empreender@Braga
IB Agência para a Dinamização Económica EM, Portugal
2020 Código+
Universidade do Minho, Portugal
2006 FCT PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2020 Stimulus of Scientific Employment, Individual Support (CEECIND) - 3rd Edition
Fundação para a Ciência e a Tecnologia, Portugal
2019 Erasmus+ Visiting Professor
Erasmus Plus, Belgium
2017 Golden Medal of Scientific Merit
Camara Municipal de Penafiel, Portugal
2017 Aula Magistralis
Instituto Politécnico de Bragança, Portugal
2016 First ranked at Investigtorship Portuguese Science and Technology Foundation (IFCT)
Fundação para a Ciência e a Tecnologia, Portugal
2013 Cover issue of “Trends in Parasitology” Journal, July 2013 with the article "Artemisinin resistance in Plasmodium falciparum: what is it really?
2013 Reviewer Acknowledgment
Malaria Journal, United States
2012 Cover of “Emerging Infectious Diseases” journal,Volume 18, Number 10—October 2012 with the work "Duffy Phenotype and Plasmodium vivax infections in Humans and Apes, Africa"
2011 JSPS Long-term Fellowship
Japan Society for the Promotion of Science Stockholm, Sweden
2010 -Best Poster Award in FEBS Special Meeting: "ATP Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases"
Federation of European Biochemical Societies, United Kingdom
2010 JSPS Fellowship
Japan Society for the Promotion of Science Stockholm, Sweden

Kungliga Vetenskapsakademien, Sweden
2009 -Cover of “The Journal of Infectious Diseases” Volume 200, Issue 9, with the work “Plasmodium falciparum Multidrug Resistance Protein 1 and Artemisinin Based Combination Therapy in Africa”
Oxford University Press, United Kingdom
2008 Reviewer Acknowledgement - Personalized Medicine
Future Medicine Ltd, United Kingdom
2004 European Community program Leonardo da Vinci
European Union, Belgium
2003 Concurso de Ideias Bioempreendedor 2003 AIP -Finalist